CN103127312A - External Antiviral and anti-pathogenic gynecological lotion and preparation technology - Google Patents
External Antiviral and anti-pathogenic gynecological lotion and preparation technology Download PDFInfo
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Abstract
The invention discloses an external antiviral and anti-pathogenic gynecological lotion, and further provides a preparation technology of the lotion. The lotion is mainly and scientifically prepared from cortex fraxini, radix sophorae flavescentis, agrimonia eupatoria, herba houttuyniae, folium isatidis and herba violae. The Chinese herbal composition has the effects of clearing damp, preventing bacteria, killing worms, relieving itching and eliminating peculiar smell and has the advantages of quick clinical symptom disappear, obvious curative effect, no skin mucous membrane irratation, no irritability, no toxic and side effect, no cloth pollution, high safety and comfortability; and the lotion has a short treatment course and is low in cost and convenient to use.
Description
Technical field
The present invention discloses the antiviral gynecological external use lotion of a kind of antiviral, and the preparation technology of this lotion also is provided simultaneously, all selects natural Chinese medicinal herb to make, and belongs to traditional Chinese medical science pharmaceutical technology field.
Background technology
Gynecological inflammation common are vaginitis, urethritis, cervical erosion, pruritus vulvae, leucorrhea abnormal etc., great majority cause due to various antibacterials or fungal infection, external used medicine chemical synthetic drug commonly used is take Antibiotics as main at present, though these drug effects are fast, touch absorption and human body is caused certain toxic and side effects but many medicines can glue by vagina, some medicines also have certain carcinogenesis through zoopery.The Antibiotics medicine is easy to make vaginal microbial flora to change when being used for vaginitis, causes dysbacteriosis, and then brings out superinfection.Although there is the Chinese patent medicine of a lot for the treatment of gynecological inflammations in market, but most of curative effects are undesirable, these medicines are many exists defective because of prescription and preparation technology, in light of this situation, according to the gynecological inflammation etiology and pathogenesis, establish rational prescription, improve preparation technology to improve the content of effective ingredient, become urgent problem.
Summary of the invention
The invention provides the antiviral gynecological external use lotion of a kind of antiviral, have clinical symptom disappearance rapid, treating both the principal and secondary aspects of a disease is difficult for the characteristics that recur after curing.
The present invention further discloses the preparation technology of the antiviral gynecological external use lotion of antiviral, be applicable to suitability for industrialized production.
Technical solution of the present invention be based on China's Chinese medicine to the general cognition of gynaecological inflammation disease and modern medicine to this disease pathogeny and Therapeutic Principle, pass through clearing heat and expelling damp, subduing swelling and detoxicating, the blood stasis dispelling eliminating carbuncle, promoting the circulation of QI to relieve pain and reach the treatment gynecological inflammation purpose, for the antiviral gynecological external use lotion of the antiviral that provides, made by ratio of weight and the number of copies by following medicine with reaching this order:
Cortex Fraxini 250 ~ 320, Radix Sophorae Flavescentis 130 ~ 180, Herba Agrimoniae 130 ~ 180, Herba Houttuyniae 180 ~ 230, Folium Isatidis 130 ~ 180, Herba Violae 230 ~ 280.
The antiviral gynecological external use lotion of antiviral disclosed by the invention, its optimum ratio is:
Cortex Fraxini 300, Radix Sophorae Flavescentis 150, Herba Agrimoniae 150, Herba Houttuyniae 200, Folium Isatidis 150, Herba Violae 250.
The preparation method of the antiviral gynecological external use lotion of antiviral provided by the invention comprises the following steps:
Get above-mentioned all medicines, decoct with water three times; Add for the first time 10 times of amounts of water, extracted 1.5 hours, filter; Add for the second time 8 times of amounts of water, extracted 1 hour, filter; Add for the third time 8 times of amounts of water, extracted 1 hour, filter; Merge three times filtrate, be concentrated into relative density 1.12(60 ℃ survey), add 4 times of amount ethanol precipitate with ethanol, standing 24 hours, filter.Filtrate recycling ethanol is to relative density 1.14-1.18(60 ℃ survey), concentrated solution is diluted with water to 1000ml, and standing 24 hours, get the supernatant packing, sterilization, and get final product.
Using method:Get the present invention 10 ~ 15ml, inject intravaginal, prevent overflow of drug fluid, keep more than 20 minutes.1 time on the 1st.
Indication:Heat clearing and damp drying is except itching leukorrhagia stopping.Cure mainly the damp-heat accumulation type leukorrheal diseases, i.e. the genus damp-heat accumulation person of non-specific, the mycotic of women, trichomonal vaginitis.Clinically see that profuse leukorrhea, yellow skin or HUANGBAI(sic) hold concurrently mutually, the diseases such as sagging distention in the smaller abdomen or pain, pudendal pruritus, oliguria, puckery pain.
The side separates:Above-mentioned selected Chinese medicine is the medicinal herbs most in use of all kinds of gynecological inflammation class of clinical treatment disease, has solid clinical practice basis, and wherein, Cortex Fraxini is pained cold, enters liver, gallbladder, large intestine channel.The heat clearing away of cold energy, but hardship dampness are for " thing of clear cold clear green decline is distinguished foul smell, and " (" book on Chinese herbal medicine remittance speech ") is therefore kind " married woman's leukorrhagia " (" Mingyi Bielu ") for the treatment of in loose gas convergence." book on Chinese herbal medicine converges and says " controls " married woman's leucorrhea with red and white discharge " with it, proves that further this product especially should humid tropics purgation disease.In the side, the Cortex Fraxini consumption is maximum, but power is got the effect of heat clearing and damp drying, and heat is moved back wet removing, and foul smell is distinguished, and leukorrhagia is from stopping.This medicine hits pathogenesis and gets effect, therefore monarch drug in the side of being.The Radix Sophorae Flavescentis bitter cold, GUIXIN, liver, stomach, large intestine, all warps of bladder kind are controlled many damp and hotly for the disease of trouble, make contributions with heat clearing and damp drying.Leukorrhagia is damp and hot for suffering from, product the most commonly used.Because of " hot air wind producing, humidogene worm " (Compendium of Material Medica), damp-heat vaginal discharge is often accompanied pudendal pruritus again, and Radix Sophorae Flavescentis can " kill the damp and hot worm that gives birth to " (" book on Chinese herbal medicine justice "), has the effect of killing parasites for relieving itching concurrently.Herba Agrimoniae is pained flat, enters the heart, Liver Channel, also can heat clearing and damp drying, control " leucorrhea with red and white discharge " (" the southern regions of the Yunnan Province book on Chinese herbal medicine ").Two medicines are associated with, and can assist monarch drug to strengthen the heat clearing and damp drying effect, and lift the labor of ministerial drug.The Herba Houttuyniae suffering is slightly cold, and enters lung meridian, the Folium Isatidis bitter cold, and GUIXIN, stomach warp, the Herba Violae toil is cold, enters the heart, Liver Channel, and 3 are all the good medicine of heat-clearing and toxic substances removing.Though the heat-clearing and toxic substances removing function all lie on, so close and receive outward in the moon, also can removing summer-heat part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels pyretic toxicity, clearing away damp-heat from lower-JIAO, assistant helps all medicines of the monarch and his subjects with Cheng Qigong.Thereby adjuvant drug in the side of being all.The present invention's 6 flavors of getting it filled are brief agent, advocate eliminating evil, and be the special side of essence, the mutual compatibility of all medicines, synergism, mutual reinforcement between is mutually chivalrous, closes and external, can play altogether heat clearing and damp drying, removes the effect of the leukorrhagia stopping of itching.The described blood circulation promoting and blood stasis dispelling of playing altogether, the merit of pain relieving tissue regeneration promoting, sterilizing and itch-relieving is removed pruritus painful.
Further illustrate good effect of the present invention below in conjunction with clinical:
Medicine of the present invention is carried out clinical trial, investigated its curative effect and untoward reaction.Observe altogether patient's 420 examples, wherein bacterial vaginosis 140 examples (the present invention's 100 examples, matched group 40 examples), trichomonal vaginitis 140 examples (the present invention's 100 examples, matched group 40 examples), colpitis mycotica 140 examples (the present invention's 100 examples, matched group 40 examples), adopt random contrast method.Now clinical test results is summarized as follows:
1. vaginitis total effects situation
Table 1 liang group vaginitis total effects is (example) relatively
The present invention and matched group vaginitis total effects are relatively analyzed through Ridit, U=2.84, and there is statistical significance P＜0.01.Illustrate that total effects of the present invention is better than matched group.Total obvious effective rate compares, through X
2Check, X
2There is statistical significance=8.83, P＜0.005.Illustrate that the total obvious effective rate of the present invention is better than matched group.
2. sick relation of planting with the vaginitis curative effect
The relation (example) of the sick kind of table 2 liang group and vaginitis curative effect
The present invention and matched group compare, and the bacterial vaginosis Different therapeutical effect has significant, remaining the two sick Different therapeutical effects of planting without significant.Between in the present invention, disease is planted, curative effect compares, X
2=17.77, P＜0.005, curative effect has significant difference.The curative effect that this medicine is described is relevant with sick kind.
3. syndrome of accumulated dampness-heat curative effect situation
Table 3 liang group syndrome of accumulated dampness-heat curative effect situation is (example) relatively
The present invention and matched group syndrome of accumulated dampness-heat curative effect are relatively analyzed U=1.88, P through Ridit〉0.05, not statistically significant.Total obvious effective rate compares, through X
2Check, X
2There is statistical significance=6.15, P＜0.05.Illustrate that the present invention treats the total obvious effective rate of vaginitis (syndrome of accumulated dampness-heat) and is better than contrasting medicine.
4. clinical symptom disappearance situation
Two groups of clinical symptom disappearance situations of table 4 bacterial vaginosis and comparison (example) thereof
Table 4 explanation: the clinical symptom disappearance situation of two groups of bacterial vaginosis is suitable.
5. two groups of clinical symptom disappearance situations of colpitis mycotica and comparison thereof
Two groups of clinical symptom disappearance situations of table 5 colpitis mycotica and comparison (example) thereof
Table 5 explanation: the clinical symptom disappearance situation of two groups of colpitis mycoticas is suitable.
6. two groups of clinical symptom disappearance situations of trichomonal vaginitis and comparison thereof
Two groups of clinical symptom disappearance situations of table 6 trichomonal vaginitis and comparison (example) thereof
Table 6 explanation: the clinical symptom disappearance situation of two groups of trichomonal vaginitis is suitable.
7. the former situation of turning out cloudy of causing a disease
The pathogenic former situation relatively (example) of turning out cloudy of table 7 liang group
Table 7 explanation: two groups of former situations of turning out cloudy of causing a disease are suitable.
8. vagina cleanness degree situation of change
Table 8 liang group vagina cleanness degree situation of change (example)
Compare between two groups after treatment (Ridit analysis): bacterial vaginosis, U=0.19, P 0.05; Trichomonal vaginitis, U=0.15, P〉0.05; Colpitis mycotica, U=0.13, P〉0.05, equal not statistically significant.Illustrate that two groups of vagina cleanness degrees improve situation suitable.
9. picture of the tongue situation of change before and after treating
Picture of the tongue situation of change (example) before and after table 9 liang group treatment
10. pulse condition situation of change before and after treating
Pulse condition situation of change (example) before and after table 10 liang group treatment
Good effect of the present invention is:Described Chinese medicine composition has damp eliminating, antibiotic, parasite killing, antipruritic, the effect of eliminating abnormal flavour, clinical symptom disappearance is rapid, evident in efficacy, to mucocutaneous nonirritant, without anaphylaxis, have no side effect, not pollution clothes, have the height safety and comfort; Short treating period, expense are low, easy to use.
The specific embodiment
Embodiment 1
Take Cortex Fraxini 300g, Radix Sophorae Flavescentis 150g, Herba Agrimoniae 150g, Herba Houttuyniae 200g, Folium Isatidis 150g, Herba Violae 250g, decoct with water three times, add for the first time 10 times of amounts of water, extracted 1.5 hours, filter; Add for the second time 8 times of amounts of water, extracted 1 hour, filter; Add for the third time 8 times of amounts of water, extracted 1 hour, filter; Merge three times filtrate, be concentrated into relative density 1.12(60 ℃ survey), add 4 times of amount ethanol precipitate with ethanol, standing 24 hours, filter.Filtrate recycling ethanol is to relative density 1.14-1.18(60 ℃ survey), concentrated solution is diluted with water to 1000ml, and standing 24 hours, get the supernatant packing, sterilization, and get final product.
Embodiment 2
Claim Cortex Fraxini 250g, Radix Sophorae Flavescentis 130g, Herba Agrimoniae 130g, Herba Houttuyniae 180g, Folium Isatidis 130g, Herba Violae 230g, above-mentioned Chinese medicine is mixed, decoct with water three times, add for the first time 10 times of amounts of water, extracted 1.5 hours, filter; Add for the second time 8 times of amounts of water, extracted 1 hour, filter; Add for the third time 8 times of amounts of water, extracted 1 hour, filter; Merge three times filtrate, be concentrated into relative density 1.12(60 ℃ survey), add 4 times of amount ethanol precipitate with ethanol, standing 24 hours, filter.Filtrate recycling ethanol is to relative density 1.14-1.18(60 ℃ survey), concentrated solution is diluted with water to 1000ml, and standing 24 hours, get the supernatant packing, sterilization, and get final product.
Embodiment 3
Take Cortex Fraxini 320g, Radix Sophorae Flavescentis 180g, Herba Agrimoniae 180g, Herba Houttuyniae 230g, Folium Isatidis 180g, Herba Violae 280g, above-mentioned Chinese medicine is mixed, decoct with water three times, add for the first time 10 times of amounts of water, extracted 1.5 hours, filter; Add for the second time 8 times of amounts of water, extracted 1 hour, filter; Add for the third time 8 times of amounts of water, extracted 1 hour, filter; Merge three times filtrate, be concentrated into relative density 1.12(60 ℃ survey), add 4 times of amount ethanol precipitate with ethanol, standing 24 hours, filter.Filtrate recycling ethanol is to relative density 1.14-1.18(60 ℃ survey), concentrated solution is diluted with water to 1000ml, and standing 24 hours, get the supernatant packing, sterilization, and get final product.
Further prove medical effect of the present invention by following model case
Case 1
Certain female, 32 years old, married, pudendal pruritus 4 days, gynecologial examination: pudendum is normal, and vaginal mucosa is congested, steeps unconcerned shape secretions amount many, anteversion of uterus, normal size, adnexa has tenderness.Find infusorian in leucorrhea, diagnosis trichomonal vaginitis.Before treating, pathogenic bacterium are 10 minutes, pudendal pruritus 1 minute, and pudendum pain 1 minute, leucorrhea 2 minutes, vaginal mucosa had the petechia 1 minute, frequent micturition, urgent micturition, dysurea 1 minute, disease score 16 minutes; Before treating, leucorrhea is 6 minutes, and pruritus vulvae 1 minute, lower abdomen are done swollen or pain 3 minutes, bitter taste 2 minutes, and dry pharynx 3 minutes, the puckery pain of oliguria 2 minutes, red tongue with yellowish and greasy fur 1 minute, stringy and rolling pulse 1 minute, tcm symptom scoring 19 minutes, disease degree is severe, vagina cleanness degree III degree.After treatment, disease score is 0 minute, tcm symptom scoring 0 minute, vagina cleanness degree I degree, evaluation of clinical curative effect: use medicine of the present invention to treat, get 10ml of the present invention and inject intravaginal, raise buttocks and kept 20 minutes, every day 1 time, use continuously 7 times.Curative effect of disease is recovery from illness, and Syndrome in TCM marquis's curative effect is recovery from illness.Follow up a case by regular visits to and do not recur March.
Case 2
Certain female is 30 years old, married.The conscious pudendal pruritus of patient, companion's leucorrhea amount is many, the time when light heavy February medical in 2001.2.10..Gynecologial examination: the skin of vulva flushing, vaginal mucosa is congested, and grumeleuse shape leucorrhea is arranged, and dry mouth with bitter taste is occasionally arranged.Leucorrhea mycete chemical examination (+).Be diagnosed as colpitis mycotica.Give the woman cloudy health lotion treatment when medical.Use medicine of the present invention to treat: first to clean pudendum with clear water, get 10ml of the present invention and inject intravaginal, raise buttocks and kept 20 minutes, every day 1 time, use continuously 7 times.Drug withdrawal check in 3 days: the original symptom of pudendum and vagina all disappears, and leucorrhea is few.The leucorrhea mycete checks negative.Follow up a case by regular visits to and do not recur March, the clinical diagnosis recovery from illness.
Case 3
Certain female is 37 years old, married.Because of profuse leukorrhea, 3 weeks of abnormal flavour are arranged, went to a doctor in 25th in JIUYUE in 2000.The profuse leukorrhea bimester that the patient being near, the color white matter is thick, and abnormal flavour is arranged, and when sending out during pudendal pruritus, only, pudendum has a dull ache, little swollen, the dry pharynx of lower abdomen.Check finding: light red tongue, greasy and thin fur, rolling pulse.The vaginal secretions amount is many, and matter is thick, and abnormal flavour is arranged, vagina cleanness degree III °, and pH value 5.5 is found clues cell, and before treatment, integration is 16 minutes, severity extent: severe.Diagnosis: bacterial vaginosis (syndrome of accumulated dampness-heat).Use medicine of the present invention to treat: the intravaginal medicine-feeding, 10ml, the present invention injects intravaginal, prevent overflow of drug fluid, keep more than 20 minutes every day 1 time, after controlling a week, leukorrhagia obviously is reduced to normally, free from extraneous odour, all cards disappear, clues cell is not found in the vaginal secretions inspection, vagina cleanness degree I °, and pH value is 4.5, integration is 0, and does not occur any untoward reaction in therapeutic process.Efficacy determination: recovery from illness.
Claims (3)
1. antiviral gynecological external use lotion of antiviral, made by ratio of weight and the number of copies by following medicine:
Cortex Fraxini 250 ~ 320, Radix Sophorae Flavescentis 130 ~ 180, Herba Agrimoniae 130 ~ 180, Herba Houttuyniae 180 ~ 230, Folium Isatidis 130 ~ 180, Herba Violae 230 ~ 280.
2. the antiviral gynecological external use lotion of antiviral claimed in claim 1, its optimum ratio is:
Cortex Fraxini 300, Radix Sophorae Flavescentis 150, Herba Agrimoniae 150, Herba Houttuyniae 200, Folium Isatidis 150, Herba Violae 250.
3. the preparation method of the antiviral gynecological external use lotion of the described antiviral of claim 1 or 2 comprises the following steps:
Get above-mentioned all medicines, decoct with water three times, add for the first time 10 times of amounts of water, extracted 1.5 hours, filter; Add for the second time 8 times of amounts of water, extracted 1 hour, filter; Add for the third time 8 times of amounts of water, extracted 1 hour, filter; Merge three times filtrate, be concentrated into relative density 1.12(60 ℃ survey), add 4 times of amount ethanol precipitate with ethanol, standing 24 hours, filter;
Filtrate recycling ethanol is to relative density 1.14-1.18(60 ℃ survey), concentrated solution is diluted with water to 1000ml, and standing 24 hours, get the supernatant packing, sterilization, and get final product.
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| CN104547303A (en) * | 2015-01-21 | 2015-04-29 | 宿州亿帆药业有限公司 | Externally used gel for treating gynecological inflammation and preparation method thereof |
| CN105535266A (en) * | 2016-02-03 | 2016-05-04 | 许筱妹 | Compound lotion for trichomoniasis vaginalis and preparation method thereof |
| CN105770622A (en) * | 2016-04-13 | 2016-07-20 | 毕兆孝 | Traditional Chinese medicine composition for treating gynecological inflammation and preparing method and application thereof |
| CN109010644A (en) * | 2018-10-23 | 2018-12-18 | 邱其振 | A kind of gynaecology's draft antibacterial liquid |
| CN117503852A (en) * | 2023-12-15 | 2024-02-06 | 宿州亿帆药业有限公司 | Gynecological external traditional Chinese medicine composition and preparation method and application thereof |
| CN117503852B (en) * | 2023-12-15 | 2024-10-29 | 宿州亿帆药业有限公司 | Gynecological external traditional Chinese medicine composition and preparation method and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547303A (en) * | 2015-01-21 | 2015-04-29 | 宿州亿帆药业有限公司 | Externally used gel for treating gynecological inflammation and preparation method thereof |
| CN105535266A (en) * | 2016-02-03 | 2016-05-04 | 许筱妹 | Compound lotion for trichomoniasis vaginalis and preparation method thereof |
| CN105770622A (en) * | 2016-04-13 | 2016-07-20 | 毕兆孝 | Traditional Chinese medicine composition for treating gynecological inflammation and preparing method and application thereof |
| CN109010644A (en) * | 2018-10-23 | 2018-12-18 | 邱其振 | A kind of gynaecology's draft antibacterial liquid |
| CN117503852A (en) * | 2023-12-15 | 2024-02-06 | 宿州亿帆药业有限公司 | Gynecological external traditional Chinese medicine composition and preparation method and application thereof |
| CN117503852B (en) * | 2023-12-15 | 2024-10-29 | 宿州亿帆药业有限公司 | Gynecological external traditional Chinese medicine composition and preparation method and application thereof |
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Application publication date: 20130605 |