CN107050256A - Foot antimicrobial inflammation-relieving gel and preparation method thereof - Google Patents
Foot antimicrobial inflammation-relieving gel and preparation method thereof Download PDFInfo
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- CN107050256A CN107050256A CN201710079015.5A CN201710079015A CN107050256A CN 107050256 A CN107050256 A CN 107050256A CN 201710079015 A CN201710079015 A CN 201710079015A CN 107050256 A CN107050256 A CN 107050256A
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Abstract
Foot antimicrobial inflammation-relieving gel and preparation method thereof, belongs to foot anti-inflammation field of medical technology.It is usually to wipe tinea pedis medicine water or ointment, the effect only treated using painting to treat tinea pedis, it is impossible to be used in daily foot's maintenance effect, and the time fully recovered needs more than half a year.The present invention is mainly made up of Chinese medicine composite extract, glycerine, vaseline, polyethylene glycol, poloxamer, deionized water, its parts by weight be respectively 12~18 parts Chinese medicine composite extract, 6~8 parts of glycerine, 2~5 parts of vaseline, 2~4 parts of polyethylene glycol, 15~20 parts of poloxamer, 120~180 parts of deionized water, described Chinese medicine composite extract is mainly made up of Chinese alyxia herb, leaf of Japanese banana, Quince, monkshood, water pepper, eucalyptus robusta, garden euphorbia herb, Lao Xiong flowers, rhizoma atractylodis, tetrandra root, Chinese fir node, camphortree bark, aloe.The present invention is dry to pin, ringworm of the foot effective percentage reaches 100%, easy to use, lasting medicine.
Description
Technical field
The invention belongs to foot anti-inflammation field of medical technology, and in particular to a kind of foot antimicrobial inflammation-relieving gel and its system
Preparation Method.
Background technology
Pin splits to break out in cold, dry season more, is common in heel, sufficient outer rim etc., it is seen that different in size, the depth
Crack, the lighter be only dry, cutin thicken, be cracked, severe one breach is as deep as corium, easy bleeding, pain.Pin is easily produced after splitting
Tinea pedis, tinea pedis.Tinea pedis is the foot dermatosis as caused by pathogenic fungus, with infectiousness.Tinea pedis is popular in the whole world,
It is more universal in subtropical and tropical zones.In China, the incidence of disease of tinea pedis is also at a relatively high.There is no sebum between the vola of people and toe
Gland, so as to lack the aliphatic acid for suppressing skin filamentous fungi, physiological defense function is poor, and the sweat gland of skin at these positions is very
It is abundant, perspire relatively more, air circulation is poor in addition, part damp warm, is conducive to the growth of filamentous fungi.In addition, vola
Area skin cuticula is thicker, and the keratin in cuticula is the abundant nutrition material of fungi, is conducive to the growth of fungi.Its skin
Skin infringement is often first single human hair combing waste life, and just offside is arrived in infection after several weeks or several months.Blister mainly appears on toe abdomen and toe side, most often
See between three or four toes, vola also may occur in which, be deep-seated phlysis, can gradually be fused into bleb.The skin lesion of tinea pedis has one
Feature, i.e. clear border, can be gradually to external expansion.Because of disease development or scratch, may occur in which rotten to the corn, sepage, even bacterium infection,
There is warts etc..
It is usually to wipe tinea pedis medicine water or ointment using painting to treat tinea pedis, while note sanitation and hygiene and the drying of foot,
Footgear preferably often Exposure to Sunlight sterilization and the method such as changes clothes, but the ringworm of the foot liquid medicine or ointment now sold only have the effect for the treatment of, it is impossible to be used in
Daily foot's maintenance effect, and the time needs fully recovered are longer, it is general to obtain more than half a year.
The content of the invention
The present invention seeks to solve the deficiencies in the prior art there is provided a kind of short treating period, it is evident in efficacy and with maintenance work(
Foot antimicrobial inflammation-relieving gel of energy and preparation method thereof.
The present invention is achieved through the following technical solutions：
A kind of foot antimicrobial inflammation-relieving gel, described foot antimicrobial inflammation-relieving gel is mainly by Chinese medicine composite extract, sweet
Oil, vaseline, polyethylene glycol, poloxamer, deionized water are made, and its parts by weight is respectively that 12~18 parts of Chinese medicine compound is carried
Take thing, 6~8 parts of glycerine, 2~5 parts of vaseline, 2~4 parts of polyethylene glycol, 15~20 parts of poloxamer, 120~180
Part deionized water, described Chinese medicine composite extract mainly by Chinese alyxia herb, leaf of Japanese banana, Quince, monkshood, water pepper, eucalyptus robusta,
Garden euphorbia herb, Lao Xiong flowers, rhizoma atractylodis, tetrandra root, Chinese fir node, camphortree bark, aloe are made.
The parts by weight of Chinese alyxia herb are in foot antimicrobial inflammation-relieving gel of the present invention, described Chinese medicine composite extract
7~15 parts, the parts by weight of leaf of Japanese banana be 15~20 parts, Quince parts by weight be 10~20 parts, the parts by weight of monkshood be
10~15 parts, the parts by weight of water pepper be 5~10 parts, the parts by weight of eucalyptus robusta be 7~15 parts, the parts by weight of garden euphorbia herb
Be 5~10 parts for 10~20 parts, the Lao Xiong parts by weight spent, the parts by weight of rhizoma atractylodis be 20~30 parts, the parts by weight of tetrandra root
For 20~30 parts, Chinese fir node parts by weight be 10~20 parts, the parts by weight of camphortree bark be 10~20 parts, the parts by weight of aloe
Number is 10~20 parts.
Foot antimicrobial inflammation-relieving gel of the present invention, described poloxamer is model F127 and model F38
The mass ratio of the mixture of poloxamer, wherein F127 and F38 is 2:1.
Foot antimicrobial inflammation-relieving gel of the present invention, described polyethylene glycol is Macrogol 600.
Foot antimicrobial inflammation-relieving gel of the present invention, the weight of described foot antimicrobial inflammation-relieving gel Chinese medicine composite extract
It is 18 parts to measure number, and the parts by weight of glycerine are 8 parts, and the parts by weight of vaseline are 5 parts, and the parts by weight of polyethylene glycol are 4
Part, the parts by weight of poloxamer are 20 parts, and the parts by weight of deionized water are 120 parts.
Foot antimicrobial inflammation-relieving gel of the present invention, the weight of described foot antimicrobial inflammation-relieving gel Chinese medicine composite extract
It is 12 parts to measure number, and the parts by weight of glycerine are 6 parts, and the parts by weight of vaseline are 2 parts, and the parts by weight of polyethylene glycol are 2
Part, the parts by weight of poloxamer are 15 parts, and the parts by weight of deionized water are 180 parts.
The preparation method of foot antimicrobial inflammation-relieving gel of the present invention, comprises the following steps：
The preparation of step 1, Chinese medicine composite extract；
Step 2, the Chinese medicine composite extract that 12~18 parts are weighed according to parts by weight respectively, 6~8 parts of glycerine, 2~5
The vaseline of part, 2~4 parts of polyethylene glycol, 120~180 parts of deionized water are slow by load weighted Chinese medicine composite extract
Add in glycerine, then add load weighted vaseline, polyethylene glycol, deionized water, the first mixing is obtained after stirring
Liquid；
Step 3, the poloxamer for weighing according to parts by weight 15~20 parts, -4 DEG C of dimensions are placed in by load weighted poloxamer
15~30min of temperature is held, the first mixed liquor made from step 2 is slowly added to after taking-up under conditions of stirring, after stirring,
2~8h is stood, described foot antimicrobial inflammation-relieving gel is obtained.
The preparation method of foot antimicrobial inflammation-relieving gel of the present invention, the system of the Chinese medicine composite extract described in step 1
It is standby, comprise the following steps：
Step A, Chinese alyxia herb, leaf of Japanese banana, Quince, monkshood, water pepper, the great Ye for weighing according to parts by weight certain mass respectively
Eucalyptus, garden euphorbia herb, Lao Xiong flowers, rhizoma atractylodis, tetrandra root, Chinese fir node, camphortree bark, aloe, are respectively placed in Chinese medicine by load weighted Chinese medicine and surpass
1~5min is crushed in atomizer, acc power 1.8kw, pulverizer rotating speed 22000rad/min is crushed, 100 mesh sieves are crossed after crushing
It is standby；
Weighed after step B, the herb powder for crushing step A are well mixed, institute is poured into the herb powder mixed
Claim the alcoholic solution of 10~20 times of quality, carry out alcoholic extract under the cooperation of ultrasonic wave, interruption ultrasound, per hour ultrasound 5~
15min, 1000~5000Hz of supersonic frequency, 5~10h of alcoholic extract time, take supernatant A stand-by, and remaining filter residue continues to press
Soaked once with alcoholic solution according to the above method, the supernatant after immersion is merged into supernatant, obtains supernatant B；
Step C, by the supernatant B obtained in step B pass through vacuum distillation recovered alcohol, control 55~65 DEG C of temperature, pressure
- 0.1MPa, obtains Chinese medicine composite extract by force.
The preparation method of foot antimicrobial inflammation-relieving gel of the present invention, stirring condition is 100~300rad/ of speed of agitator
Min, 10~15min of mixing time.
Stirring condition in the preparation method of foot antimicrobial inflammation-relieving gel of the present invention, step 3 is speed of agitator 200
~500rad/min, 10~20min of mixing time.
Chinese alyxia herb in foot antimicrobial inflammation-relieving gel of the present invention is distributed across the chain on the ground such as Zhejiang, Fujian, Guangdong
Pearl rattan is hung down loosely or rattan shape, bald net shrub, and being used as medicine being capable of expelling wind and removing dampness, promoting blood circulation and removing obstruction in channels, treating rheumatic arthralgia, splenasthenic diarrhea, pin
Gas.Leaf of Japanese banana, is banana, is distributed in the ground such as Fujian, Guangdong, Hainan, Guangxi, Yunnan, and blade is used as medicine, it is cold in nature it is sweet,
Light, with heat-clearing, diuresis the effect of removing toxic substances, is usually used in pyreticosis, heatstroke, tinea pedis, carbuncle swells heat toxin is scalded.Quince, fruit ossphere
Shape or nearly cylinder, long 6-10cm, diameter 5-6cm, many vertical profiles are 2-4 valves, surface brown to brownish black, concavity, per room
There is 20-30, seed, majority comes off, rufous, flat triangle.Gas is micro-, sour-puckery flavor, distribution southwest and Shaanxi, Gansu, river
The ground such as west, Fujian, Hubei, Guangxi, with stomach dampness elimination, the effect of stimulating the circulation of the blood and cause the muscles and joints to relax, for vomiting and diarrhoea, soreness of waist and knee joint, tinea pedis
Swell and ache, systremma.Monkshood, is the processed goods of the sub- root of the ranunculaceae plant rhizome of Chinese monkshood, and the excavation of late June to early August is removed
Female root, fibrous root and silt, practise and claim " mud monkshood ", pungent, sweet, extremely hot in nature, with recuperating depleted yang, mends fire supporing yang, eliminating cold to stop pain
Effect.Water pepper is a kind of polygonaceae plant, for going stagnant dampness elimination, dissipate stasis of blood hemostasis, dispelling wind and arresting itching, and removing toxic substances cures mainly arthralgia pain due to rheumatism, skin
Itch, eczema, rubella, tinea pedis.Eucalyptus robusta is close shady megaphanerophyte, up to 20m, blade heavy leather matter, ovum shape lanceolar, and both sides are not
Deng, there is gland point on long 8~17cm, two sides, and dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, and anti-corrosion is antipruritic, take orally for prevent influenza,
Meningococal meningitis, controls the infection of the upper respiratory tract, and burn and scald, cellulitis, skin are controlled in sphagitis, bronchitis, pneumonia, external application
Skin eczema, the ringworm of the foot, skin degerming.Garden euphorbia herb, is the whole herb with root of euphorbia plant hairy euphorbia, with clearing heat and detoxicating, dampness removing
Antipruritic the effect of, it is usually used in lung carbuncle, acute mastitis, dysentery, diarrhea, heat gonorrhea, blood urine, eczema, the ringworm of the foot, pruitus, furuncle swelling toxin, tool
There are central analgesia, refrigeration function.Lao Xiong flowers are the root skin of malvaceae plant Cortex Abutili sinensis Radicis.It is born in height above sea level 300-2000m hillside
In sparse woods or bamboo grove, with clearing heat and detoxicating；Effect of reunion of fractured tendons and bones, cures mainly boil, the ringworm of the foot, traumatic injury, fracture etc..Rhizoma atractylodis are
Composite family [WTBX herbaceos perennial, root-like stock prostration or oblique ascension, adventitious root, rhizoma atractylodis root-like stock are used as medicine, for fortune spleen medicine, nature and flavor
Bitter Wen Xinlie, has eliminating dampness, changes the effect of turbid, analgesic, rhizoma atractylodis are pungent, bitter, warm-natured, returns spleen, stomach, Liver Channel, with drying damp and strengthening spleen, wind-dispelling
Cold dispelling, improving eyesight, dirty effect is warded off, for abdominal distention, diarrhea, oedema, arthralgia pain due to rheumatism, tinea pedis Wei lame, anemofrigid cold etc..It is anti-
, the tetrandra root in the present invention is wooden tetrandra root, and main product is in Guangdong, Guangxi, Yunnan and other places.Autumn excavates, and cleans, and removes tertia, cuts
Section, thick root rip cutting two halves are dried.Sheet is cut, raw to use, wherein main component is aristolochic acid, magnoflorine, allantoin, horse pocket
Bell lactams, cupreol etc. has effects that inducing diuresis for removing edema, wind-expelling pain-stopping, cure mainly arthralgia pain due to rheumatism, tinea pedis swell and ache, mange sore
Swell.Chinese fir node is the tubercle on Taxodiaceae China fir platymiscium China fir limb, plant China fir, cultivate extensively in China Yangtze river basin and
Qinling Mountains areas to the south, with wind-expelling pain-stopping, dissipate wet poison the effect of, cure mainly rheumatism arthralgia, stomachache, tinea pedis swell and ache, ulcer on the shank etc..
Camphortree bark, is the bark of Lauraceae cinnamon camphor tree, and camphor tree is distributed in China Guangdong, Guangxi, Yunnan, Guizhou, Jiangsu, Zhejiang, peace
The ground such as emblem, Fujian, Taiwan, Jiangxi, Hubei, Hunan, Sichuan, with dispelling wind and eliminating dampness, warm stomach is with, and the effect of desinsection treats sore is main
Arthralgia pain due to rheumatism is controlled, gastral cavity pain, vomiting and diarrhea, tinea pedis swells and ache, traumatic injury, mange sore, insect bite etc..Aloe is lily
Section perennial evergreen herbaceous plant, it is leafage life, big and plump, in seat shape or stem top is born in, the normal lanceolar of leaf or the short width of leaf, edge
Have sharp tooth thorn, with sterilization, anti-inflammatory, moisturizing, cardiac stimulant promoting blood circulation effect, promote immune and regenerate, it is removing toxic substances, analgesia, calm, anti-
Shine, cure mainly scabies, carbuncle furuncle poison, traumatic injury.
The significant Chinese alyxia herb of selected effect of foot antimicrobial inflammation-relieving gel of the present invention, leaf of Japanese banana, Quince, monkshood, water
High-quality genunie medicinal materials compatibility rhizoma atractylodis, tetrandra root, Chinese fir node, the camphortree barks such as knotweed, eucalyptus robusta, garden euphorbia herb, Lao Xiong flowers are super using Chinese medicine
After atomizer crushes rhizoma atractylodis, tetrandra root, Chinese fir node, camphortree bark, aloe, whole medicinal materials are placed in alcohol and extracted, alcohol energy
It is enough by the water-soluble and oil-soluble composition combination Chinese alyxia herb in rhizoma atractylodis, tetrandra root, Chinese fir node, camphortree bark, it is leaf of Japanese banana, Quince, attached
Son, water pepper, eucalyptus robusta, garden euphorbia herb, Lao Xiong flowers, the traditional Chinese medicine ingredients of aloe, are extracted into Chinese medicine composite extract, fully completely
Extract various middle the effective elements of the medicines so that described described foot antimicrobial inflammation-relieving gel has the dry, ringworm of the foot for the treatment of pin etc. many
Plant effect.Poloxamer has temperature sensitivity in the present invention, is liquid at subzero 4 degree, is then semisolid under normal temperature, therefore
Poloxamer hydrogel needs to carry out at low ambient temperatures in the preparation, and by screening, general it is left 15% as substrates quantity
The suitable gel of viscosity can be made in the right side, and poloxamer is in itself without physiologically active, no hemolytic, to no skin irritation, nothing
Toxicity, as a kind of oil-water emulsifiers, can fully dispersed Chinese medicine composite extract, the state of gel causes drug effect after smearing
Retention time increases.And present invention addition glycerine, vaseline, polyethylene glycol, and increase the extraction component of aloe, enable to
The present invention has certain moisturizing, the effect of skin care.
Foot antimicrobial inflammation-relieving gel of the present invention is by plurality of raw materials mix and match, and scientific composition, each raw material advantage is mutual
Mend, using its mutual collaboration or resistant function, add moisturizing skin care ingredient, such as glycerine, vaseline, polyethylene glycol,
The stimulation to skin is reduced, pedal skin is nourished, smears very easy to use, because in gel, water lock is good, is difficult to wave
Hair is dried, and effective ingredient can be released slowly into up to focus for a long time, and the symptom such as treatment pin is done, ringworm of the foot has good treatment
Effect.
The present invention is dry to pin, ringworm of the foot effective percentage reaches 100%, easy to use, lasting medicine of the invention, it is evident in efficacy,
And Chinese medicine compound prescription, has no toxic side effect, non-stimulated effect, and with certain moisturizing, skin care effect, it can be used in usually
Foodcare health care.
Embodiment
Embodiment one：
A kind of foot antimicrobial inflammation-relieving gel, described foot antimicrobial inflammation-relieving gel is mainly by Chinese medicine composite extract, sweet
Oil, vaseline, polyethylene glycol, poloxamer, deionized water are made, and its parts by weight is respectively 12 parts of Chinese medicine compound collecting
Thing, 6 parts of glycerine, 2 parts of vaseline, 2 parts of polyethylene glycol, 15 parts of poloxamer, 120 parts of deionized water, it is described
Chinese medicine composite extract mainly by Chinese alyxia herb, leaf of Japanese banana, Quince, monkshood, water pepper, eucalyptus robusta, garden euphorbia herb, Lao Xiong spend, it is grey
Art, tetrandra root, Chinese fir node, camphortree bark, aloe are made.
The parts by weight of Chinese alyxia herb in foot antimicrobial inflammation-relieving gel described in present embodiment, described Chinese medicine composite extract
Number is 7 parts, the parts by weight of leaf of Japanese banana are 15 parts, Quince parts by weight are 10 parts, the parts by weight of monkshood are 10 parts, water pepper
Parts by weight be 5 parts, the parts by weight of eucalyptus robusta be 7 parts, the parts by weight of garden euphorbia herb be 10 parts, the parts by weight of Lao Xiong flowers
Number is 5 parts, the parts by weight of rhizoma atractylodis are 20 parts, the parts by weight of tetrandra root are 20 parts, the parts by weight of Chinese fir node are 10 parts, camphor tree
The parts by weight of skin are 10 parts, the parts by weight of aloe are 10 parts.
Foot antimicrobial inflammation-relieving gel described in present embodiment, described poloxamer is model F127 and model
The mass ratio of the mixture of F38 poloxamer, wherein F127 and F38 is 2:1.
Foot antimicrobial inflammation-relieving gel described in present embodiment, described polyethylene glycol is Macrogol 600.
Described foot antimicrobial inflammation-relieving gel prepared by present embodiment carries out irritation test test, and method of testing is divided into
Multiple intact skin irritant test and disposable damaged skin irritant test：
Multiple intact skin Irritation Test Method is the healthy white rabbits 3 of selection body weight 20-25kg, and 24h will before experiment
The hair of white rabbit back backbone both sides is cut, the left and right each about 3cm*3cm of unhairing scope.Next day, described foot antibacterial is disappeared
Scorching gel 0.5ml is uniformly applied to side skin of unhairing surface, and opposite side skin of unhairing is used as blank control.4h is smeared, with steaming
Distilled water removes residual tested material, smears once daily, continuously smears 14d, if necessary cropping, not injured skin.Smearing every time
24h observes result afterwards；
The healthy white rabbits 3 of disposable damaged skin irritant test selection body weight 20-25kg, test preceding 24h by rabbit
The hair of back backbone both sides is cut, the left and right each about 3cm*3cm of unhairing scope.Next day, first sterilized with concentration for 75% alcohol wipe
Unhairing area skin, with the damaged wound of injection needle standardized " well " shape in dermatotome, the foot antibacterial described in 0.5ml is disappeared
Scorching gel is applied on the 4 layers of gauze covered on damaged part skin, is then covered with one layer of oilpaper, then solid with nonirritant adhesive plaster
It is fixed.Opposite side unhairing damaged skin, as control, is equally handled with equivalent sterile purified water with preceding work.After application 4h, with distillation
Water remove residual described in foot antimicrobial inflammation-relieving gel, respectively at remove tested material after 1,24,48h, observation local skin reaction.
The conclusion of two groups of skin irritation tests is：Skin irritation test result shows, described foot anti-inflammation
Gel, without significant change, is determined as nonirritant to the multiple irritant test rabbit epidermis of rabbit intact skin；To the damaged skin of rabbit
The disposable irritant test of skin, rabbit epidermis is determined as nonirritant without significant change.
Shown by 2 groups of experiments, not spirituosity and western medicine composition in described foot antimicrobial inflammation-relieving gel, excitant are micro-
Its is micro-.
Embodiment two：
The preparation method of foot antimicrobial inflammation-relieving gel according to embodiment one, comprises the following steps：
The preparation of step 1, Chinese medicine composite extract；
Step 2, the Chinese medicine composite extract for weighing according to parts by weight 12 parts respectively, 6 parts of glycerine, 2 parts of vaseline,
2 parts of polyethylene glycol, 120 parts of deionized water, load weighted Chinese medicine composite extract is slowly added in glycerine, is then added again
Enter load weighted vaseline, polyethylene glycol, deionized water, the first mixed liquor is obtained after stirring；
Step 3, the poloxamer for weighing according to parts by weight 15 parts, are placed in -4 DEG C by load weighted poloxamer and maintain temperature
15min is spent, the first mixed liquor made from step 2 is slowly added to after taking-up under conditions of stirring, after stirring, 2h is stood,
Obtain described foot antimicrobial inflammation-relieving gel.
The preparation method of foot antimicrobial inflammation-relieving gel according to present embodiment, the Chinese medicine described in step 1, which is combined, to be carried
The preparation of thing is taken, is comprised the following steps：
Step A, Chinese alyxia herb, leaf of Japanese banana, Quince, monkshood, water pepper, the great Ye for weighing according to parts by weight certain mass respectively
Eucalyptus, garden euphorbia herb, Lao Xiong flowers, rhizoma atractylodis, tetrandra root, Chinese fir node, camphortree bark, aloe, are respectively placed in Chinese medicine by load weighted Chinese medicine and surpass
1min is crushed in atomizer, acc power 1.8kw, pulverizer rotating speed 22000rad/min is crushed, 100 mesh sieves are crossed after crushing standby
With；
Weighed after step B, the herb powder for crushing step A are well mixed, institute is poured into the herb powder mixed
Claim the alcoholic solution of 10~20 times of quality, alcoholic extract is carried out under the cooperation of ultrasonic wave, interruption ultrasound is ultrasonic per hour
5min, supersonic frequency 1000Hz, alcoholic extract time 5h, take supernatant A stand-by, and remaining filter residue continues to use according to the method described above
Alcoholic solution is soaked once, and the supernatant after immersion is merged into supernatant, obtains supernatant B；
Step C, by the supernatant B obtained in step B by vacuum distillation recovered alcohol, control 55 DEG C of temperature, pressure-
0.1MPa, obtains Chinese medicine composite extract.
Stirring condition in the preparation method of foot antimicrobial inflammation-relieving gel according to present embodiment, step 2 is to stir
Mix rotating speed 100rad/min, mixing time 10min.
Stirring condition in the preparation method of foot antimicrobial inflammation-relieving gel described in present embodiment, step 3 turns for stirring
Fast 200rad/min, mixing time 10min.
Foot antimicrobial inflammation-relieving gel prepared by the preparation method of the foot antimicrobial inflammation-relieving gel described in present embodiment, this reality
Apply mode initial experiment with place 6 months after measure staphylococcus aureus, Candida albicans, bacillus canalis capsulatus,
The action time of Escherichia coli is 2min, and extension rate is the test result under 1 times, as shown in table 1, it can be seen from Table 1 that
Present embodiment has good fungistatic effect.
The bacteriostatic experiment test result of table 1
Embodiment three：
A kind of foot antimicrobial inflammation-relieving gel, described foot antimicrobial inflammation-relieving gel is mainly by Chinese medicine composite extract, sweet
Oil, vaseline, polyethylene glycol, poloxamer, deionized water are made, and its parts by weight is respectively 18 parts of Chinese medicine compound collecting
Thing, 8 parts of glycerine, 5 parts of vaseline, 4 parts of polyethylene glycol, 20 parts of poloxamer, 180 parts of deionized water, it is described
Chinese medicine composite extract mainly by Chinese alyxia herb, leaf of Japanese banana, Quince, monkshood, water pepper, eucalyptus robusta, garden euphorbia herb, Lao Xiong spend, it is grey
Art, tetrandra root, Chinese fir node, camphortree bark, aloe are made.
The weight of Chinese alyxia herb in foot antimicrobial inflammation-relieving gel according to present embodiment, described Chinese medicine composite extract
Amount number is 15 parts, the parts by weight of leaf of Japanese banana are 20 parts, Quince parts by weight are 20 parts, the parts by weight of monkshood are 15
Part, the parts by weight of water pepper be 10 parts, the parts by weight of eucalyptus robusta be 15 parts, the parts by weight of garden euphorbia herb be 20 parts, Lao Xiong
Colored parts by weight are 10 parts, the parts by weight of rhizoma atractylodis are 30 parts, the parts by weight of tetrandra root are 30 parts, the parts by weight of Chinese fir node
For 20 parts, camphortree bark parts by weight be 20 parts, the parts by weight of aloe be 20 parts.
Foot antimicrobial inflammation-relieving gel according to present embodiment, described poloxamer is model F127 and model
For the mixture of F38 poloxamer, wherein F127 and F38 mass ratio are 2:1.
Foot antimicrobial inflammation-relieving gel according to present embodiment, described polyethylene glycol is Macrogol 600.
The preparation method of foot antimicrobial inflammation-relieving gel according to present embodiment, comprises the following steps：
The preparation of step 1, Chinese medicine composite extract；
Step 2, the Chinese medicine composite extract for weighing according to parts by weight 18 parts respectively, 8 parts of glycerine, 5 parts of vaseline,
4 parts of polyethylene glycol, 180 parts of deionized water, load weighted Chinese medicine composite extract is slowly added in glycerine, is then added again
Enter load weighted vaseline, polyethylene glycol, deionized water, the first mixed liquor is obtained after stirring；
Step 3, the poloxamer for weighing according to parts by weight 20 parts, are placed in -4 DEG C by load weighted poloxamer and maintain temperature
30min is spent, the first mixed liquor made from step 2 is slowly added to after taking-up under conditions of stirring, after stirring, 8h is stood,
Obtain described foot antimicrobial inflammation-relieving gel.
The preparation method of foot antimicrobial inflammation-relieving gel according to present embodiment, the Chinese medicine described in step 1, which is combined, to be carried
The preparation of thing is taken, is comprised the following steps：
Step A, Chinese alyxia herb, leaf of Japanese banana, Quince, monkshood, water pepper, the great Ye for weighing according to parts by weight certain mass respectively
Eucalyptus, garden euphorbia herb, Lao Xiong flowers, rhizoma atractylodis, tetrandra root, Chinese fir node, camphortree bark, aloe, are respectively placed in Chinese medicine by load weighted Chinese medicine and surpass
5min is crushed in atomizer, acc power 1.8kw, pulverizer rotating speed 22000rad/min is crushed, 100 mesh sieves are crossed after crushing standby
With；
Weighed after step B, the herb powder for crushing step A are well mixed, institute is poured into the herb powder mixed
Claim the alcoholic solution of 20 times of quality, alcoholic extract is carried out under the cooperation of ultrasonic wave, interruption is ultrasonic, per hour ultrasound 15min, surpasses
Acoustic frequency 5000Hz, alcoholic extract time 10h, takes supernatant A stand-by, and remaining filter residue continues molten with alcohol according to the method described above
Immersion is steeped once, and the supernatant after immersion is merged into supernatant, obtains supernatant B；
Step C, by the supernatant B obtained in step B by vacuum distillation recovered alcohol, control 65 DEG C of temperature, pressure-
0.1MPa, obtains Chinese medicine composite extract.
Stirring condition in the preparation method of foot antimicrobial inflammation-relieving gel according to present embodiment, step 2 is to stir
100~300rad/min of mix rotating speed, 10~15min of mixing time.
Stirring condition in the preparation method of foot antimicrobial inflammation-relieving gel according to present embodiment, step 3 is to stir
200~500rad/min of mix rotating speed, 10~20min of mixing time.
Foot antimicrobial inflammation-relieving gel prepared by present embodiment is used to ringworm of the foot patient, is directly applied to affected part, daily 1
It is secondary, it is within 30 days 1 course for the treatment of, patient totally 100 people, record is as shown in table 2 using rear efficacy result within every 10 days.
Table 2 uses foot antimicrobial inflammation-relieving gel Comparison of therapeutic table
, it can be seen that the present invention reaches 100% to the effective percentage of ringworm of the foot patient, compared to traditional beriberi medicament from table 2
Cream instant effect of the present invention, cures short treating period, and curative effect is notable.The present invention have easy to use, lasting medicine, it is evident in efficacy,
To tinea pedis, the ringworm of the foot, pin is dry good therapeutic effect, and Chinese medicine compound prescription, has no toxic side effect, non-stimulated effect.
Claims (10)
1. a kind of foot antimicrobial inflammation-relieving gel, it is characterised in that：Described foot antimicrobial inflammation-relieving gel is mainly combined by Chinese medicine
Extract, glycerine, vaseline, polyethylene glycol, poloxamer, deionized water are made, and its parts by weight is respectively 12~18 parts
Chinese medicine composite extract, 6~8 parts of glycerine, 2~5 parts of vaseline, 2~4 parts of polyethylene glycol, 15~20 parts of pool Lip river are husky
Nurse, 120~180 parts of deionized water, described Chinese medicine composite extract mainly by Chinese alyxia herb, leaf of Japanese banana, Quince, monkshood,
Water pepper, eucalyptus robusta, garden euphorbia herb, Lao Xiong flowers, rhizoma atractylodis, tetrandra root, Chinese fir node, camphortree bark, aloe are made.
2. foot antimicrobial inflammation-relieving gel according to claim 1, it is characterised in that：In described Chinese medicine composite extract Ah
The parts by weight of sharp rattan are 7~15 parts, the parts by weight of leaf of Japanese banana are 15~20 parts, Quince parts by weight are 10~20 parts,
The parts by weight of monkshood are 10~15 parts, the parts by weight of water pepper are 5~10 parts, the parts by weight of eucalyptus robusta are 7~15 parts, big
The parts by weight of hairy euphorbia are 10~20 parts, the parts by weight of Lao Xiong flowers are 5~10 parts, the parts by weight of rhizoma atractylodis are 20~30
Part, the parts by weight of tetrandra root be 20~30 parts, the parts by weight of Chinese fir node be 10~20 parts, the parts by weight of camphortree bark be 10~
20 parts, the parts by weight of aloe be 10~20 parts.
3. foot antimicrobial inflammation-relieving gel according to claim 1 or 2, it is characterised in that：Described poloxamer is model
For F127 and the mixture of model F38 poloxamer, wherein F127 and F38 mass ratio are 2:1.
4. foot antimicrobial inflammation-relieving gel according to claim 1 or 2, it is characterised in that：Described polyethylene glycol is poly- second
Glycol 600.
5. foot antimicrobial inflammation-relieving gel according to claim 1, it is characterised in that：In described foot antimicrobial inflammation-relieving gel
The parts by weight of medicine composite extract are 18 parts, and the parts by weight of glycerine are 8 parts, and the parts by weight of vaseline are 5 parts, poly- second two
The parts by weight of alcohol are 4 parts, and the parts by weight of poloxamer are 20 parts, and the parts by weight of deionized water are 120 parts.
6. foot antimicrobial inflammation-relieving gel according to claim 1, it is characterised in that：In described foot antimicrobial inflammation-relieving gel
The parts by weight of medicine composite extract are 12 parts, and the parts by weight of glycerine are 6 parts, and the parts by weight of vaseline are 2 parts, poly- second two
The parts by weight of alcohol are 2 parts, and the parts by weight of poloxamer are 15 parts, and the parts by weight of deionized water are 180 parts.
7. the preparation method of the foot antimicrobial inflammation-relieving gel described in a kind of one of claim 1-6, it is characterised in that：Including as follows
Step：
The preparation of step 1, Chinese medicine composite extract；
Step 2, the Chinese medicine composite extract that weighs according to parts by weight 12~18 parts respectively, 6~8 parts of glycerine, 2~5 parts
Vaseline, 2~4 parts of polyethylene glycol, 120~180 parts of deionized water, load weighted Chinese medicine composite extract is slowly added to
In glycerine, load weighted vaseline, polyethylene glycol, deionized water are then added, the first mixed liquor is obtained after stirring；
Step 3, the poloxamer for weighing according to parts by weight 15~20 parts, are placed in -4 DEG C by load weighted poloxamer and maintain temperature
15~30min is spent, the first mixed liquor made from step 2 is slowly added to after taking-up under conditions of stirring, after stirring, stood
2~8h, obtains described foot antimicrobial inflammation-relieving gel.
8. the preparation method of foot antimicrobial inflammation-relieving gel according to claim 7, it is characterised in that：In described in step 1
The preparation of medicine composite extract, comprises the following steps：
Step A, the Chinese alyxia herb for weighing according to parts by weight certain mass respectively, leaf of Japanese banana, Quince, monkshood, water pepper, eucalyptus robusta,
Garden euphorbia herb, Lao Xiong flowers, rhizoma atractylodis, tetrandra root, Chinese fir node, camphortree bark, aloe, Chinese herbal ultra-fine powder is respectively placed in by load weighted Chinese medicine
1~5min is crushed in broken machine, acc power 1.8kw, pulverizer rotating speed 22000rad/min is crushed, 100 mesh sieves are crossed after crushing standby；
Weighed after step B, the herb powder for crushing step A are well mixed, alleged matter is poured into the herb powder mixed
10~20 times of alcoholic solution of amount, carries out alcoholic extract under the cooperation of ultrasonic wave, interruption ultrasound, per hour ultrasound 5~
15min, 1000~5000Hz of supersonic frequency, 5~10h of alcoholic extract time, take supernatant A stand-by, and remaining filter residue continues to press
Soaked once with alcoholic solution according to the above method, the supernatant after immersion is merged into supernatant, obtains supernatant B；
Step C, by the supernatant B obtained in step B by vacuum distillation recovered alcohol, control 55~65 DEG C of temperature, pressure-
0.1MPa, obtains Chinese medicine composite extract.
9. the preparation method of foot antimicrobial inflammation-relieving gel according to claim 7, it is characterised in that：Stirring in step 2
Condition is 100~300rad/min of speed of agitator, 10~15min of mixing time.
10. the preparation method of foot antimicrobial inflammation-relieving gel according to claim 7, it is characterised in that：Stirring in step 3
Condition is 200~500rad/min of speed of agitator, 10~20min of mixing time.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115317526A (en) * | 2022-06-22 | 2022-11-11 | 浙江工业大学 | Bacteriostatic emulsion for treating tinea pedis and preparation method thereof |
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| KR20150059872A (en) * | 2013-11-25 | 2015-06-03 | 김윤철 | Crude vegetable material as a main material composition and manufacturing method and athlete's foot treatment |
| CN105079305A (en) * | 2015-08-28 | 2015-11-25 | 吉林大学 | Antisepsis and anti-inflammation external traditional Chinese medicine compound gel and preparation method thereof |
| CN105878507A (en) * | 2016-05-19 | 2016-08-24 | 张湛曼 | Traditional Chinese medicine composition gel for treating otitis media and preparation method thereof |
| CN106214873A (en) * | 2016-08-31 | 2016-12-14 | 李海峰 | Traditional Chinese medicine gel cream note for the treatment of tinea pedis and preparation method thereof |
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| CN102716305A (en) * | 2012-06-11 | 2012-10-10 | 丽水职业技术学院 | Foot health care lotion composition and preparation method of foot health care lotion composition |
| KR20150059872A (en) * | 2013-11-25 | 2015-06-03 | 김윤철 | Crude vegetable material as a main material composition and manufacturing method and athlete's foot treatment |
| CN105079305A (en) * | 2015-08-28 | 2015-11-25 | 吉林大学 | Antisepsis and anti-inflammation external traditional Chinese medicine compound gel and preparation method thereof |
| CN105878507A (en) * | 2016-05-19 | 2016-08-24 | 张湛曼 | Traditional Chinese medicine composition gel for treating otitis media and preparation method thereof |
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Application publication date: 20170818 |