CN102293931A - Traditional Chinese medicinal composition, clinical preparation and preparation methods thereof - Google Patents
Traditional Chinese medicinal composition, clinical preparation and preparation methods thereof Download PDFInfo
- Publication number
- CN102293931A CN102293931A CN 201110247677 CN201110247677A CN102293931A CN 102293931 A CN102293931 A CN 102293931A CN 201110247677 CN201110247677 CN 201110247677 CN 201110247677 A CN201110247677 A CN 201110247677A CN 102293931 A CN102293931 A CN 102293931A
- Authority
- CN
- China
- Prior art keywords
- weight portions
- radix
- chilblain
- parts
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 52
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 208000010445 Chilblains Diseases 0.000 claims abstract description 82
- 239000003814 drug Substances 0.000 claims abstract description 38
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 25
- 229940098465 tincture Drugs 0.000 claims abstract description 20
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 28
- 229940025250 camphora Drugs 0.000 claims description 24
- 239000010238 camphora Substances 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000002674 ointment Substances 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 20
- 239000002994 raw material Substances 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 241000628997 Flos Species 0.000 claims description 12
- 241000180649 Panax notoginseng Species 0.000 claims description 11
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 10
- 239000010775 animal oil Substances 0.000 claims description 9
- 235000021355 Stearic acid Nutrition 0.000 claims description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 8
- 239000008117 stearic acid Substances 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 7
- -1 hexanol amine Chemical class 0.000 claims description 6
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N n-hexyl alcohol Natural products CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 claims description 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 6
- 229920000053 polysorbate 80 Polymers 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 239000006071 cream Substances 0.000 abstract description 5
- 241000213006 Angelica dahurica Species 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 abstract description 3
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract description 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract description 2
- 241000304195 Salvia miltiorrhiza Species 0.000 abstract description 2
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 abstract description 2
- 241000173529 Aconitum napellus Species 0.000 abstract 1
- 235000017965 Asarum canadense Nutrition 0.000 abstract 1
- 241000723346 Cinnamomum camphora Species 0.000 abstract 1
- 235000000385 Costus speciosus Nutrition 0.000 abstract 1
- 241001558017 Gynura Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 244000297179 Syringa vulgaris Species 0.000 abstract 1
- 235000004338 Syringa vulgaris Nutrition 0.000 abstract 1
- 241000606265 Valeriana jatamansi Species 0.000 abstract 1
- 235000014687 Zingiber zerumbet Nutrition 0.000 abstract 1
- 229940023019 aconite Drugs 0.000 abstract 1
- 229960000846 camphor Drugs 0.000 abstract 1
- 229930008380 camphor Natural products 0.000 abstract 1
- 239000011505 plaster Substances 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 description 32
- 208000002193 Pain Diseases 0.000 description 17
- 230000000694 effects Effects 0.000 description 17
- LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical class CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 13
- 208000003251 Pruritus Diseases 0.000 description 10
- 239000000843 powder Substances 0.000 description 10
- 239000008280 blood Substances 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 8
- 238000010298 pulverizing process Methods 0.000 description 8
- 208000006820 Arthralgia Diseases 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 6
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 208000026435 phlegm Diseases 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 4
- 240000008384 Capsicum annuum var. annuum Species 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 4
- IGWDEVSBEKYORK-UHFFFAOYSA-N isoimperatorin Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC=C(C)C IGWDEVSBEKYORK-UHFFFAOYSA-N 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 208000004371 toothache Diseases 0.000 description 4
- 238000010792 warming Methods 0.000 description 4
- XFSBVAOIAHNAPC-XTHSEXKGSA-N 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@@]45C6[C@@H]([C@@]([C@H]31)(OC(C)=O)[C@@H](O)[C@@H]2OC)[C@H](OC)[C@@H]4[C@]([C@@H](C[C@@H]5OC)O)(COC)CN6CC)C(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-XTHSEXKGSA-N 0.000 description 3
- DHJXZSFKLJCHLH-BMTFSNIDSA-N 369u7a6hxd Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@@]45[C@H]6[C@@H]([C@@]([C@H]31)(O)[C@@H](O)[C@@H]2OC)[C@H](OC)[C@@H]4[C@]([C@@H](C[C@@H]5OC)O)(COC)CN6CC)C(=O)C1=CC=CC=C1 DHJXZSFKLJCHLH-BMTFSNIDSA-N 0.000 description 3
- XFSBVAOIAHNAPC-UHFFFAOYSA-N Aconitin Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(OC(C)=O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-UHFFFAOYSA-N 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 241000283898 Ovis Species 0.000 description 3
- 241000282894 Sus scrofa domesticus Species 0.000 description 3
- 229940039750 aconitine Drugs 0.000 description 3
- STDXGNLCJACLFY-UHFFFAOYSA-N aconitine Natural products CCN1CC2(COC)C(O)CC(O)C34C5CC6(O)C(OC)C(O)C(OC(=O)C)(C5C6OC(=O)c7ccccc7)C(C(OC)C23)C14 STDXGNLCJACLFY-UHFFFAOYSA-N 0.000 description 3
- DHJXZSFKLJCHLH-UHFFFAOYSA-N benzoylaconine Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 DHJXZSFKLJCHLH-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- QTAGQHZOLRFCBU-CYBMUJFWSA-N (+)-oxypeucedanin Chemical compound CC1(C)O[C@@H]1COC1=C(C=CO2)C2=CC2=C1C=CC(=O)O2 QTAGQHZOLRFCBU-CYBMUJFWSA-N 0.000 description 2
- ZPSAEGUNYMEKBP-UHFFFAOYSA-N 5-Isopentenyloxy-psoralen Natural products CC(C)C=COc1c2C=CC(=O)Oc2cc3occc13 ZPSAEGUNYMEKBP-UHFFFAOYSA-N 0.000 description 2
- BGEBZHIAGXMEMV-UHFFFAOYSA-N 5-methoxypsoralen Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC BGEBZHIAGXMEMV-UHFFFAOYSA-N 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 2
- 241000227129 Aconitum Species 0.000 description 2
- BEYIWVKWKJROGZ-UHFFFAOYSA-N Alloimperatorin Natural products O1C(=O)C=CC2=C1C(O)=C1OC=CC1=C2OCC=C(C)C BEYIWVKWKJROGZ-UHFFFAOYSA-N 0.000 description 2
- 241001105170 Angelica anomala Species 0.000 description 2
- 208000002881 Colic Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 206010016807 Fluid retention Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- AGBCLJAHARWNLA-DQUQINEDSA-N Ginsenoside Rg2 Natural products O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]3C(C)(C)[C@@H](O)CC[C@]3(C)[C@@H]3[C@@]([C@@]4(CC[C@@H]([C@H]4[C@H](O)C3)[C@@](C)(O)CCC=C(C)C)C)(C)C2)O[C@H](CO)[C@@H](O)[C@@H]1O AGBCLJAHARWNLA-DQUQINEDSA-N 0.000 description 2
- 241001278898 Glycyrrhiza inflata Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- KGGUASRIGLRPAX-UHFFFAOYSA-N Meranzin hydrate Natural products C1=CC(=O)OC2=C(CC(O)C(C)(C)O)C(OC)=CC=C21 KGGUASRIGLRPAX-UHFFFAOYSA-N 0.000 description 2
- QTAGQHZOLRFCBU-UHFFFAOYSA-N Oxypeucadanin Natural products CC1(C)OC1COC1=C(C=CO2)C2=CC2=C1C=CC(=O)O2 QTAGQHZOLRFCBU-UHFFFAOYSA-N 0.000 description 2
- NUCBCBCPICFGMZ-UHFFFAOYSA-N Oxypeucedanin Natural products CC1(C)OC1COC1=CC(=O)OC2=C1C=C1C=COC1=C2 NUCBCBCPICFGMZ-UHFFFAOYSA-N 0.000 description 2
- MWEVYJRFLDKUCW-UHFFFAOYSA-N Oxypeucedonin-hydrat Natural products CC(C)(O)C(O)Cc1c2C=CC(=O)Oc2cc3occc13 MWEVYJRFLDKUCW-UHFFFAOYSA-N 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- BMLZFLQMBMYVHG-UHFFFAOYSA-N Phellopterin Chemical compound O1C(=O)C=CC2=C1C(OCC=C(C)C)=C1OC=CC1=C2OC BMLZFLQMBMYVHG-UHFFFAOYSA-N 0.000 description 2
- XXARIFJTXNCWNT-UHFFFAOYSA-N Phellopterin Natural products COc1c2C=CC(=O)Oc2c(OC=CC(C)C)c3occc13 XXARIFJTXNCWNT-UHFFFAOYSA-N 0.000 description 2
- 241000218201 Ranunculaceae Species 0.000 description 2
- 241000447727 Scabies Species 0.000 description 2
- UZXMLGUMBQQVME-UHFFFAOYSA-N Swietenocoumarin B Natural products O1C(=O)C=CC2=C1C(CC=C(C)C)=C1OC=CC1=C2OC UZXMLGUMBQQVME-UHFFFAOYSA-N 0.000 description 2
- YURJSTAIMNSZAE-UHFFFAOYSA-N UNPD89172 Natural products C1CC(C2(CC(C3C(C)(C)C(O)CCC3(C)C2CC2O)OC3C(C(O)C(O)C(CO)O3)O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O YURJSTAIMNSZAE-UHFFFAOYSA-N 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 210000000577 adipose tissue Anatomy 0.000 description 2
- 230000000146 antalgic effect Effects 0.000 description 2
- BBFQZRXNYIEMAW-UHFFFAOYSA-N aristolochic acid I Chemical compound C1=C([N+]([O-])=O)C2=C(C(O)=O)C=C3OCOC3=C2C2=C1C(OC)=CC=C2 BBFQZRXNYIEMAW-UHFFFAOYSA-N 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- SQMGCPHFHQGPIF-UUKFDUHUSA-N gns9eex31x Chemical compound O[C@@H]([C@]([C@H]([C@H](O)[C@]12O)OC)(O)C3)[C@H]2[C@@H]3[C@@]2([C@H](C[C@H]3O)OC)[C@H]4[C@@H]1[C@H](OC)[C@@H]2[C@]3(COC)CN4CC SQMGCPHFHQGPIF-UUKFDUHUSA-N 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- OLOOJGVNMBJLLR-UHFFFAOYSA-N imperatorin Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OCC=C(C)C OLOOJGVNMBJLLR-UHFFFAOYSA-N 0.000 description 2
- XKVWLLRDBHAWBL-UHFFFAOYSA-N imperatorin Natural products CC(=CCOc1c2OCCc2cc3C=CC(=O)Oc13)C XKVWLLRDBHAWBL-UHFFFAOYSA-N 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- XUHJBXVYNBQQBD-UHFFFAOYSA-N mesaconitine Natural products COC1CC(O)C2(COC)CN(C)C3C(C(C45)(OC(C)=O)C(O)C6OC)C(OC)C2C31C4CC6(O)C5OC(=O)C1=CC=CC=C1 XUHJBXVYNBQQBD-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- XUHJBXVYNBQQBD-GQPWXMLZSA-N molport-002-525-145 Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@]45[C@@H]6[C@@H](OC)[C@H]([C@@]([C@H]31)(OC(C)=O)[C@@H](O)[C@@H]2OC)[C@H]4N(C)C[C@@]6([C@@H](C[C@@H]5OC)O)COC)C(=O)C1=CC=CC=C1 XUHJBXVYNBQQBD-GQPWXMLZSA-N 0.000 description 2
- HRWVKZXRZVVBLP-UHFFFAOYSA-N oxypeucedanin hydrate Natural products CC(C)(O)C(O)CCc1c2C=CC(=O)Oc2cc3occc13 HRWVKZXRZVVBLP-UHFFFAOYSA-N 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 235000019633 pungent taste Nutrition 0.000 description 2
- 208000005687 scabies Diseases 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- BDCURAWBZJMFIK-OGVVJMRYSA-N (1S,2R,3R,4S,5S,6S,8S,9S,10R,13S,16S,17R)-11-ethyl-6,16-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,8-diol Chemical compound O[C@@H]1[C@H]2[C@@H]3[C@@]4([C@@H]5C6)[C@@H](OC)CC[C@@]5(COC)CN(CC)[C@@H]4[C@H]6[C@@]2(O)C[C@H](OC)[C@H]1C3 BDCURAWBZJMFIK-OGVVJMRYSA-N 0.000 description 1
- AGBCLJAHARWNLA-UHFFFAOYSA-N (20R)-ginsenoside Rg2 Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C3C(C)(C)C(O)CCC3(C)C3C(C4(CCC(C4C(O)C3)C(C)(O)CCC=C(C)C)C)(C)C2)OC(CO)C(O)C1O AGBCLJAHARWNLA-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 241000701413 Aconitum kusnezoffii Species 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 241000913823 Apios taiwaniana Species 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 241000331777 Arisaema balansae Species 0.000 description 1
- 241000758794 Asarum Species 0.000 description 1
- DBMJZOMNXBSRED-UHFFFAOYSA-N Bergamottin Natural products O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC=C(C)CCC=C(C)C DBMJZOMNXBSRED-UHFFFAOYSA-N 0.000 description 1
- 241001313857 Bletilla striata Species 0.000 description 1
- 241001279228 Campylotropis hirtella Species 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 206010008528 Chillblains Diseases 0.000 description 1
- 235000021511 Cinnamomum cassia Nutrition 0.000 description 1
- 208000009084 Cold Injury Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 241001310717 Daphne genkwa Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- UFNDONGOJKNAES-UHFFFAOYSA-N Ginsenoside Rb1 Natural products CC(=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CC(O)C45C)C UFNDONGOJKNAES-UHFFFAOYSA-N 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 241000612122 Myrsine Species 0.000 description 1
- 206010029155 Nephropathy toxic Diseases 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010062104 Renal mass Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010051373 Wound haemorrhage Diseases 0.000 description 1
- 241000032846 Zanthoxylum bungeanum Species 0.000 description 1
- 241001079064 Zanthoxylum schinifolium Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- MDFCJNFOINXVSU-ZEDVMUKVSA-N benzoylhypaconine Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@]45[C@@H](OC)CC[C@@]6([C@H]4[C@@H](OC)[C@H]([C@](O)([C@H]31)[C@@H](O)[C@@H]2OC)[C@H]5N(C)C6)COC)C(=O)C1=CC=CC=C1 MDFCJNFOINXVSU-ZEDVMUKVSA-N 0.000 description 1
- PULWZCUZNRVAHT-LOCDBSKESA-N benzoylmesaconine Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@]45[C@@H]6[C@@H](OC)[C@H]([C@@]([C@H]31)(O)[C@@H](O)[C@@H]2OC)[C@H]4N(C)C[C@@]6([C@@H](C[C@@H]5OC)O)COC)C(=O)C1=CC=CC=C1 PULWZCUZNRVAHT-LOCDBSKESA-N 0.000 description 1
- PULWZCUZNRVAHT-UHFFFAOYSA-N benzoylmesaconine Natural products COC1CC(O)C2(COC)CN(C)C3C(C(C45)(O)C(O)C6OC)C(OC)C2C31C4CC6(O)C5OC(=O)C1=CC=CC=C1 PULWZCUZNRVAHT-UHFFFAOYSA-N 0.000 description 1
- PULWZCUZNRVAHT-YESQXFQNSA-N benzoylmesaconitine Chemical compound O([C@H]1[C@@]2(O)C[C@@H]3C45[C@@H]6[C@@H](OC)C([C@@]([C@H]31)(O)[C@@H](O)[C@@H]2OC)C4N(C)C[C@@]6([C@@H](CC5OC)O)COC)C(=O)C1=CC=CC=C1 PULWZCUZNRVAHT-YESQXFQNSA-N 0.000 description 1
- 229960002045 bergapten Drugs 0.000 description 1
- KGZDKFWCIPZMRK-UHFFFAOYSA-N bergapten Natural products COC1C2=C(Cc3ccoc13)C=CC(=O)O2 KGZDKFWCIPZMRK-UHFFFAOYSA-N 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000002595 cold damage Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- GZYPWOGIYAIIPV-JBDTYSNRSA-N ginsenoside Rb1 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)O[C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC[C@]4(C)[C@H]3C[C@H]2O)C)(C)CC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GZYPWOGIYAIIPV-JBDTYSNRSA-N 0.000 description 1
- TXEWRVNOAJOINC-UHFFFAOYSA-N ginsenoside Rb2 Natural products CC(=CCCC(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C)C TXEWRVNOAJOINC-UHFFFAOYSA-N 0.000 description 1
- YURJSTAIMNSZAE-HHNZYBFYSA-N ginsenoside Rg1 Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YURJSTAIMNSZAE-HHNZYBFYSA-N 0.000 description 1
- CBEHEBUBNAGGKC-UHFFFAOYSA-N ginsenoside Rg1 Natural products CC(=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5CC(OC6OC(CO)C(O)C(O)C6O)C34C)C CBEHEBUBNAGGKC-UHFFFAOYSA-N 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000037306 mature skin Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 150000002773 monoterpene derivatives Chemical class 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000004084 narcotic analgesic agent Substances 0.000 description 1
- 230000007694 nephrotoxicity Effects 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- JURZHOVRCOWZFN-UHFFFAOYSA-N notoginsenoside R1 Natural products CC(=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5C(CC34C)OC6OC(COC7OCC(O)C(O)C7O)C(O)C(O)C6O)C JURZHOVRCOWZFN-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 230000000590 parasiticidal effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- BDCURAWBZJMFIK-XFFYPZHLSA-N talatisamine Natural products CCN1C[C@@]2(COC)CC[C@H](OC)[C@@]34[C@@H]5C[C@H]6[C@H](O)[C@@H]5[C@](O)(C[C@@H]6OC)[C@@H](C[C@H]23)[C@@H]14 BDCURAWBZJMFIK-XFFYPZHLSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicinal composition, a clinical preparation and preparation methods thereof. The traditional Chinese medicinal composition comprises the following components in parts by weight: 5-10 parts of manchurian wildginger, 5-10 parts of rhizoma bletillae, 5-10 parts of pericarpium zanthoxyli, 5-10 parts of cassia twig, 5-10 parts of angelica dahurica, 5-10 parts of gynura root, 5-10 parts of raw rhubarb, 5-10 parts of salvia miltiorrhiza, 5-10 parts of raw aconite root, 5-10 parts of raw radix aconiti agrestis, 10-20 parts of raw liquorice root, 15-30 parts of camphor, 10-20 parts of lilac daphne flower and 8-10 parts of calcined plaster. The test of medicament effectiveness shows that the traditional Chinese medicinal composition provided by the invention and preparations of chilblain tincture and chilblain cream can be effectively used for curing chilblain.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly a kind of Chinese medicine composition, clinical preparation and preparation method.
Background technology
Chilblain is because the cold limitation inflammation infringement that causes, positions such as the back of the hand of patient, instep, auricle, buccal are often of a specified duration excessively because of it is attacked by the cold and evil, occur red and swollenly sending out cool, pruritus pain, even purple dark, the disease such as fester of skin.China has 200,000,000 people to be subjected to the puzzlement of chilblain every year approximately, wherein mainly is child, women and old people.In a single day chilblain takes place, often more difficult rapid healing in cold season, and the patient endures puzzlement to the fullest extent.
At present, the medicine of treatment chilblain has multiple, all can not eliminate red, symptom such as swell, itch after the use at short notice, can not thoroughly effect a radical cure for rotten to the corn and intractable chilblain, and cure rate is lower.
Summary of the invention
In view of this, the invention provides a kind of Chinese medicine composition, clinical preparation and preparation method for the treatment of chilblain.This Chinese medicine composition and preparation have better therapeutic effect to chilblain.
In order to realize the foregoing invention purpose, the invention provides following technical scheme:
A kind of Chinese medicine composition for the treatment of chilblain is characterized in that, is made by following weight portion raw material:
Wherein, Herba Asari has another name called thin ginseng, bowl of a pipe flower, the Semen Oroxyli section of being born in the year of horse, the asarum plant, all herbal medicine (because of its aerial parts Aristolochic Acid too high levels, and Aristolochic Acid has nephrotoxicity, thereby 2005 editions " Chinese pharmacopoeia has changed root and rhizome into and has been used as medicine), warm in nature, acrid in the mouth, function dispelling cold by warming the meridian, dissipating fluid-retention, wind-expelling pain-stopping cure mainly diseases such as headche due to wind-cold, phlegm retention cough with asthma, rheumatic arthralgia, toothache, nasal sinusitis.
The Pseudobulbus Bletillae (Rhizoma Bletillae), the dry tuber for orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata (Thunb.) Reichb.f. has astringing to arrest bleeding, and wound hemorrhage, carbuncle, scald, furuncle etc. are controlled in effects such as detumescence and promoting granulation, external application.
Fructus Zanthoxyli, for dry mature skin (Pericarpium Zanthoxyli) and the seed (Semen zanthoxyli) of rutaceae green pepper (fragrant green pepper, Zanthoxylum schinifolium, Pericarpium Zanthoxyli, Canis familiaris L. green pepper) ZanthoxylumschinifoliumSieb.etZucc. or Pericarpium Zanthoxyli (another name for Sichuan Province green pepper, Fructus Zanthoxyli, Capsicum tetragonum, pericarpium zanthoxyli bungeani, Radix Campylotropis Hirtella (Herba Myrsines Africanae)) ZanthoxylumbungeanumMaxim. is used as medicine, there is fragrance to be good for the stomach, warming spleen and stomach for dispelling cold, removing damp and stopping pain, parasite killing detoxifcation, antipruritic effect of separating raw meat, main treatment vomiting, anemofrigid-damp arthralgia, diseases such as toothache.
Ramulus Cinnamomi is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl, main product in Guangxi, ground such as Guangdong and Yunnan.Spring, summer are cut twig, dry or dry in the shade, and thinly slice or segment is used.Grace can reach the diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, and supporing yang activating QI, the flat gas that spins is used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
The Radix Angelicae Dahuricae, formal name used at school is A.dahurica (Fisch.) Benth.et Hook, another name Radix Angelicae Dahuricae (Radix Heraclei Scabridi) (Fujian, Taiwan, provinces such as Zhejiang), the storehouse page or leaf Radix Angelicae Dahuricae (Sichuan), pray the Radix Angelicae Dahuricae (Henan, Hebei), be the samphire Xingan Radix Angelicae Dahuricae (praying the Radix Angelicae Dahuricae) (Angelica dahurica Benth.et Hook.), storehouse and the Radix Angelicae Dahuricae (angelica anomala) (A.anomala Lall.) and Radix angelicae dahuricae (Radix Angelicae Dahuricae (Radix Heraclei Scabridi)) (A.taiwaniana Boiss., epith.mut.) root is used as medicine, contain isoimperatorin (isoimperatorin), imperatorin (imperatorin), bergapton (bergapten), phellopterin (phellopterin), oxypeucedanin (oxypeucedanin) etc., has expelling pathogenic wind from the body surface, dispersing cold for relieving pain, it is sensible to dehumidify, the effect of detumescence and apocenosis cures mainly anemofrigid cold, headache, rhinitis, toothache.Diseases such as leucorrhea with red and white discharge, pain furuncle and phyma poison.
Radix Notoginseng, the dry root for panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen contains Saponin, is mainly ginsenoside Rb1, Rg1, Rg2 and a small amount of ginsenoside Ra, Rb2, Rb and Re.In addition, still contain flavonoid glycoside, starch, protein, oils and fats etc., can dissipating blood stasis hemostasis, subduing swelling and relieving pain is used for various inside and outside hemorrhagely, spitting of blood is spitted blood, epistaxis is had blood in stool, metrorrhagia, breast ventral spine pain, tumbling and swelling.
Radix Et Rhizoma Rhei is the decoction pieces of primary crude drug, and major function is stasis removing, hemostasis by removing blood stasis, relieving constipation by purgation, and it is stagnant to be used for the gastrointestinal excess-heat, constipation.
Radix Salviae Miltiorrhizae, have another name called Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae, Arisaema balansae Engl. etc., the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge., main product in Anhui, ground such as Henan, Shaanxi, effect is a promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.
Radix Aconiti is the parent root of ranunculaceae plant Ka Shi Aconitum carmichjaelii Debx. AconitumcarmichaeliDebx., total alkaloid content 2.3%, ester 1.0%, aconitine 0.3%.Mainly contain under aconitine (aconitine), mesaconitine (mesaconitine), tower skill aconine (talatisamine), outstanding this aconine (jasaconitine), benzoyl aconine (benzoylaconine), benzoyl mesaconitine (benzoylmesaconine) and the benzoyl aconine (benzoylhypaconine) etc.Grace can reach expelling wind and removing dampness, and antalgic is used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type and has a pain.
Radix Aconiti Kusnezoffii is the tuber of Ranunculaceae herbaceos perennial Aconitum carmichjaelii Debx. (wild species) or Aconitum kusnezoffii Reichb.Expelling wind and removing dampness is arranged, and the effect of antalgic is used for anemofrigid-damp arthralgia, arthralgia, and trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Radix Glycyrrhizae is glycyrrhizic legume Glycyrrhiza uralensis Fisch., the dry root and rhizome of Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L., invigorating the spleen and replenishing QI is arranged, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription is used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Camphora, formal name used at school: 1,7,7-trimethyl bicyclo-[2,2,1] heptane-2-ketone.A kind of cyclohexane extraction monoterpene derivative.Ketone from bark and the wooden distillation of Lignum cinnamomi camphorae makes has the dehumidifying parasite killing, and warming and odynolysis is had one's ideas straightened out and warded off dirty effect, cures mainly scabies pruritus, traumatic pain, toothache.
Flos Genkwa, Flos Genkwa are the dry flower of thymelaeceae plant Flos Genkwa Daphne genkwa Sieb, and removing fluid-retention by purgation is arranged, and the parasiticidal effect of detoxifying is used for the treatment of the edema distension, breast abdomen hydrops, and phlegm retention is gathered, and QI rising in reverse order is breathed with cough, difficulty in urination and defecation; External treatment scabies tinea alba, chilblain.
Gypsum Fibrosum Preparatum is the processed product of Gypsum Fibrosum, can removing dampness, and granulation promoting is held back skin ulcer, hemostasis; The external treatment ulcer being unable to heal, eczema pruritus, burn due to hot liquid or fire, diseases such as traumatic hemorrhage.
Based on this, Chinese medicine composition provided by the invention is made by above-mentioned raw materials.
The present invention also provides the clinical preparation that comprises above-mentioned Chinese medicine composition.
In some embodiments of the invention, the clinical preparation that comprises above-mentioned Chinese medicine composition is a tincture, and in other embodiment provided by the invention, the clinical preparation that comprises above-mentioned Chinese medicine composition is an emulsifiable paste.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of chilblain, get the Herba Asari of 5～10 weight portions, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5～10 weight portions, the Fructus Zanthoxyli of 5～10 weight portions, the Ramulus Cinnamomi of 5～10 weight portions, the Radix Angelicae Dahuricae of 5～10 weight portions, the Radix Notoginseng of 5～10 weight portions, the Radix Et Rhizoma Rhei of 5～10 weight portions, the Radix Salviae Miltiorrhizae of 5～10 weight portions, the Radix Aconiti of 5～10 weight portions, the Radix Aconiti Kusnezoffii of 5～10 weight portions, the Radix Glycyrrhizae of 10～20 weight portions, the Flos Genkwa of 10～20 weight portions, the Gypsum Fibrosum Preparatum of 8～10 weight portions, add 600～1000mL water and stir back decoction 30～60min, be cooled to 40～60 ℃, the Camphora that adds 15～30 weight portions, stir postcooling to 20～30 ℃, promptly.
The present invention also provides the Chinese medicine composition by above-mentioned preparation method preparation.
The present invention also provides a kind of tincture for the treatment of chilblain, its preparation method is, get the Herba Asari of 5～10 weight portions, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5～10 weight portions, the Fructus Zanthoxyli of 5～10 weight portions, the Ramulus Cinnamomi of 5～10 weight portions, the Radix Angelicae Dahuricae of 5～10 weight portions, the Radix Notoginseng of 5～10 weight portions, the Radix Et Rhizoma Rhei of 5～10 weight portions, the Radix Salviae Miltiorrhizae of 5～10 weight portions, the Radix Aconiti of 5～10 weight portions, the Radix Aconiti Kusnezoffii of 5～10 weight portions, the Radix Glycyrrhizae of 10～20 weight portions, the Flos Genkwa of 10～20 weight portions, after the Gypsum Fibrosum Preparatum of 8～10 weight portions is pulverized, priority is 75% and 60% ethanol lixiviate with 200～250mL concentration, the Camphora that adds 15～30 weight portions mixes, promptly.
As preferably, in the preparation method of tincture, lixiviate is for soaking 7～15d or soak 48～72h under 50 ℃ of water bath condition at 15～40 ℃.
In embodiment more provided by the invention, the preparation method of tincture is specially, and is made by following weight portion raw material:
After getting all the other the described raw material pulverizing except that Camphora, be that 75% ethanol soaks 7～15d or soak 48～72h under 50 ℃ of water bath condition at 15～40 ℃ with 200～250mL concentration, filter and collect the rear filtrate of lixiviate for the first time; Collect filtering residue, be that 60% ethanol soaks 7～15d or soak 48～72h under 50 ℃ of water bath condition at 15～40 ℃ with 200～250mL concentration, collect the rear filtrate of lixiviate for the second time, merge rear filtrate of lixiviate for the first time and the rear filtrate of lixiviate for the second time, heating is concentrated into 200～250mL, the dissolving that camphorates, promptly.
The present invention also provides a kind of emulsifiable paste for the treatment of chilblain, its preparation method is, get the Herba Asari of 5～10 weight portions, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5～10 weight portions, the Fructus Zanthoxyli of 5～10 weight portions, the Ramulus Cinnamomi of 5～10 weight portions, the Radix Angelicae Dahuricae of 5～10 weight portions, the Radix Notoginseng of 5～10 weight portions, the Radix Et Rhizoma Rhei of 5～10 weight portions, the Radix Salviae Miltiorrhizae of 5～10 weight portions, the Radix Aconiti of 5～10 weight portions, the Radix Aconiti Kusnezoffii of 5～10 weight portions, the Radix Glycyrrhizae of 10～20 weight portions, after the Flos Genkwa of 10～20 weight portions is pulverized, decoct, filtering and collecting filter liquid, concentrate the back and add tween 80 6mL, glycerol 10mL, three hexanol amine 2mL are heated to 70～80 ℃, being heated to 70～80 ℃ of solution that obtain with the Bai Fanlin of the stearic acid of 20 weight portions and 40 weight portions mixes, be cooled to 30～55 ℃ of Camphora mixing that add the Gypsum Fibrosum Preparatum and 15～30 weight portions of 8～10 weight portions, promptly.
As preferably, the preparation method of emulsifiable paste is that the amount of water of decoction is 400～500mL.
As preferably, the preparation method of emulsifiable paste is that decoction is twice decoction; Decoct for the first time 1～3h, decoct 0.6～1.5h for the second time.
Preferably, Gypsum Fibrosum Preparatum is a Gypsum Fibrosum powder (calcined).
In other embodiment provided by the invention, the preparation method of emulsifiable paste is specially, and is made by following weight portion raw material:
Get Camphora, after the described raw material pulverizing of outside the Gypsum Fibrosum Preparatum all the other, adding 400～500mL decocting boils, decoct for the first time 1～3h, filter the back collection and decoct rear filtrate for the first time, collect filtering residue and decoct 40～90min for the second time, filter the back collection and decoct rear filtrate for the second time, merge and decoct rear filtrate for the first time and decoct rear filtrate for the second time, heating is concentrated into 120～150mL, add tween 80 6mL, glycerol 10mL, three hexanol amine 2mL are heated to 70～80 ℃, be heated to 70～80 ℃ of solution that obtain with the Bai Fanlin of the stearic acid of 20 weight portions and 40 weight portions and mix, after the cooling promptly.
The present invention also provides a kind of chilblain ointment, its preparation method is heated to 100～120 ℃ for getting 400～800mL animal oil, the Herba Asari that adds 5～10 weight portions, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5～10 weight portions, the Fructus Zanthoxyli of 5～10 weight portions, the Ramulus Cinnamomi of 5～10 weight portions, the Radix Angelicae Dahuricae of 5～10 weight portions, the Radix Notoginseng of 5～10 weight portions, the Radix Et Rhizoma Rhei of 5～10 weight portions, the Radix Salviae Miltiorrhizae of 5～10 weight portions, the Radix Aconiti of 5～10 weight portions, the Radix Aconiti Kusnezoffii of 5～10 weight portions, the Radix Glycyrrhizae of 10～20 weight portions, the Flos Genkwa of 10～20 weight portions, fry in shallow oil after the stirring and press 30～50min, be cooled to 40～60 ℃, add the Camphora of 15～30 weight portions and the Gypsum Fibrosum Preparatum of 8～10 weight portions, stir postcooling to 20～30 ℃, promptly.
As preferably, animal oil is Adeps Caprae seu ovis or Adeps Sus domestica.
Adeps Caprae seu ovis is white or little yellow waxy solid, relative density 0.943～0.952.42～48 ℃ of fusing points.Iodine number 38～42.Saponification number 194-199.Main component is the triglyceride of oleic acid, stearic acid and Palmic acid.Be near the internal organs of sheep and subcutaneous fatty tissue, produce with the infusion method.Be used for soap system, stearic acid, glycerol, aliphatic alcohol, fatty amine, fatty acid, lubricated wet goods.Fresh ester can be edible after making with extra care.Many internal organs and the subcutaneus adipose tissues and getting by the infusion sheep of Adeps Caprae seu ovis.
Adeps Sus domestica claims big oil, lard again,, Chinese also are referred to as lard or big oil, are refined by Carnis Sus domestica.
Preferably, Gypsum Fibrosum Preparatum is a Gypsum Fibrosum powder (calcined).
The invention provides a kind of Chinese medicine composition, preparation, Preparation method and use.This Chinese medicine composition is made up of the Herba Asari of 5～10 weight portions, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5～10 weight portions, the Fructus Zanthoxyli of 5～10 weight portions, the Ramulus Cinnamomi of 5～10 weight portions, the Radix Angelicae Dahuricae of 5～10 weight portions, the Radix Notoginseng of 5～10 weight portions, the Radix Et Rhizoma Rhei of 5～10 weight portions, the Radix Salviae Miltiorrhizae of 5～10 weight portions, the Radix Aconiti of 5～10 weight portions, the Radix Aconiti Kusnezoffii of 5～10 weight portions, the Radix Glycyrrhizae of 10～20 weight portions, the Camphora of 15～30 weight portions, the Flos Genkwa of 10～20 weight portions, the Gypsum Fibrosum Preparatum of 8～10 weight portions.The test of pesticide effectiveness shows that Chinese medicine composition provided by the invention and preparation chilblain tincture, chilblain emulsifiable paste, chilblain ointment can effectively be cured chilblain.
The specific embodiment
The invention discloses a kind of Chinese medicine composition, clinical preparation and preparation method.Those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as being included in the present invention.Method of the present invention and application are described by preferred embodiment, the related personnel obviously can change or suitably change and combination methods and applications as herein described in not breaking away from content of the present invention, spirit and scope, realizes and use the technology of the present invention.
Medical material among the present invention all can be buied by market.
Below in conjunction with embodiment, further set forth the present invention:
Embodiment 1 preparation Chinese medicine composition provided by the invention
The described raw materials of except that Camphora all the other are added in 600mL water, stir the back and decoct 30min, be cooled to 50 ℃, camphorate, stir postcooling to 30 ℃, promptly.
Embodiment 2 preparations Chinese medicine composition provided by the invention
The described raw materials of except that Camphora all the other are added in 1000mL water, stir the back and decoct 60min, be cooled to 40 ℃, camphorate, stir postcooling to 30 ℃, promptly.
Embodiment 3 preparations Chinese medicine composition provided by the invention
The described raw materials of except that Camphora all the other are added in 800mL water, stir the back and decoct 40min, be cooled to 60 ℃, camphorate, stir postcooling to 25 ℃, receive cream promptly.
Embodiment 4 preparations chilblain tincture provided by the invention
After getting all the other the described raw material pulverizing except that Camphora, be that 75% ethanol soaks 10d or soak 56h under 50 ℃ of water bath condition at 25 ℃ with 250mL concentration, filter and collect the rear filtrate of lixiviate for the first time; Collecting filtering residue, is that 60% ethanol soaks 7d or soak 56h under 50 ℃ of water bath condition at 25 ℃ with 250mL concentration, collects the rear filtrate of lixiviate for the second time, merge rear filtrate of lixiviate for the first time and the rear filtrate of lixiviate for the second time, heating is concentrated into 250mL, the dissolving that camphorates, promptly.
Embodiment 5 preparations chilblain tincture provided by the invention
After getting all the other the described raw material pulverizing except that Camphora, be that 75% ethanol soaks 15d or soak 72h under 50 ℃ of water bath condition at 15 ℃ with 200mL concentration, filter and collect the rear filtrate of lixiviate for the first time; Collecting filtering residue, is that 60% ethanol soaks 15d or soak 72h under 50 ℃ of water bath condition at 15 ℃ with 200mL concentration, collects the rear filtrate of lixiviate for the second time, merge rear filtrate of lixiviate for the first time and the rear filtrate of lixiviate for the second time, heating is concentrated into 200mL, the dissolving that camphorates, promptly.
Embodiment 6 preparations chilblain tincture provided by the invention
After getting all the other the described raw material pulverizing except that Camphora, be that 75% ethanol soaks 7d or soak 48h under 50 ℃ of water bath condition at 40 ℃ with 230mL concentration, filter and collect the rear filtrate of lixiviate for the first time; Collecting filtering residue, is that 60% ethanol soaks 7d or soak 48h under 50 ℃ of water bath condition at 40 ℃ with 230mL concentration, collects the rear filtrate of lixiviate for the second time, merge rear filtrate of lixiviate for the first time and the rear filtrate of lixiviate for the second time, heating is concentrated into 220mL, the dissolving that camphorates, promptly.
Embodiment 7 preparations chilblain emulsifiable paste provided by the invention
Get Camphora, after the described raw material pulverizing of outside the Gypsum Fibrosum powder (calcined) all the other, adding the 400mL decocting boils, decoct for the first time 1h, filter the back collection and decoct rear filtrate for the first time, collect filtering residue and decoct 1.5h for the second time, filter the back collection and decoct rear filtrate for the second time, merge and decoct rear filtrate for the first time and decoct rear filtrate for the second time, heating is concentrated into 120mL, add tween 80 6mL, glycerol 10mL, three hexanol amine 2mL are heated to 70 ℃, are heated to 70 ℃ of solution that obtain with the Bai Fanlin of the stearic acid of 20 weight portions and 40 weight portions and mix, and are cooled to 30 ℃, camphorate and Gypsum Fibrosum powder (calcined), mix promptly.
Embodiment 8 preparations chilblain emulsifiable paste provided by the invention
Get Camphora, after the described raw material pulverizing of outside the Gypsum Fibrosum powder (calcined) all the other, adding the 500mL decocting boils, decoct for the first time 3h, filter the back collection and decoct rear filtrate for the first time, collect filtering residue and decoct 0.6h for the second time, filter the back collection and decoct rear filtrate for the second time, merge and decoct rear filtrate for the first time and decoct rear filtrate for the second time, heating is concentrated into 150mL, add tween 80 6mL, glycerol 10mL, three hexanol amine 2mL are heated to 80 ℃, are heated to 80 ℃ of solution that obtain with the Bai Fanlin of the stearic acid of 20 weight portions and 40 weight portions and mix, and are cooled to 55 ℃, camphorate and Gypsum Fibrosum powder (calcined), mix promptly.
Embodiment 9 preparations chilblain emulsifiable paste provided by the invention
Get Camphora, after the described raw material pulverizing of outside the Gypsum Fibrosum Preparatum all the other, adding the 450mL decocting boils, decoct for the first time 2h, filter the back collection and decoct rear filtrate for the first time, collect filtering residue and decoct 1.2h for the second time, filter the back collection and decoct rear filtrate for the second time, merge and decoct rear filtrate for the first time and decoct rear filtrate for the second time, heating is concentrated into 135mL, add tween 80 6mL, glycerol 10mL, three hexanol amine 2mL are heated to 75 ℃, are heated to 75 ℃ of solution that obtain with the Bai Fanlin of the stearic acid of 20 weight portions and 40 weight portions and mix, and are cooled to 45 ℃, camphorate and Gypsum Fibrosum Preparatum, mix promptly.
Embodiment 10 preparations chilblain ointment provided by the invention
Animal oil is heated to 110 ℃, and the described raw material of all the other except that Camphora, Gypsum Fibrosum powder (calcined) adds in the described animal oil of 800mL, fries in shallow oil after the stirring and presses 30min, is cooled to 60 ℃, camphorates and Gypsum Fibrosum powder (calcined), stirs postcooling to 25 ℃, receives cream promptly.
Embodiment 11 preparations chilblain ointment provided by the invention
Animal oil is heated to 100 ℃, and the described raw material of all the other except that Camphora, Gypsum Fibrosum powder (calcined) adds in the described animal oil of 400mL, fries in shallow oil after the stirring and presses 50min, is cooled to 50 ℃, camphorates and Gypsum Fibrosum powder (calcined), stirs postcooling to 30 ℃, receives cream promptly.
Embodiment 12 preparations chilblain ointment provided by the invention
Animal oil is heated to 120 ℃, and the described raw material of all the other except that Camphora, Gypsum Fibrosum Preparatum adds in the described animal oil of 600mL, fries in shallow oil after the stirring and presses 40min, is cooled to 40 ℃, camphorates and Gypsum Fibrosum Preparatum, stirs postcooling to 30 ℃, receives cream promptly.
The test of pesticide effectiveness of embodiment 13 Chinese medicine compositions provided by the invention, chilblain tincture, chilblain emulsifiable paste, chilblain ointment
In national northwest, southwest, northeast, North China, the southeast, Central China 60 altogether of picked at random every profession and trade personage chilblain patients respectively, the ill time limit 1 year did not wait to 52 years, was divided into 2 groups of indoor and outdoors according to occupation type, 30 every group by the investigation patients; Distinguish according to sex, 2 groups of Chinese medicine compositions that provide with the embodiment of the invention 1 to 3 of male patient and female patient are provided the chilblain patient is executed control, therapeutic effect sees Table 1.
Table 1 traditional Chinese medicine composition for treating chilblain provided by the invention effect
By table 1 result as can be known, Chinese medicine composition provided by the invention is 83.3% to office work patient's cure rate, and obvious effective rate is 16.7%, and total effective rate is 100%; Cure rate to the outside work patient is 70%, and obvious effective rate is 30%.Chinese medicine composition provided by the invention is 84.2% to male patient's cure rate, and obvious effective rate is 15.8%; Cure rate to female patient is 63.6%, and obvious effective rate is 36.4%, and total effective rate is 100%.
In national northwest, southwest, northeast, North China, the southeast, Central China 60 altogether of each age chilblain patients of picked at random respectively, the ill time limit 1 year did not wait to 48 years, distinguished according to the age, be divided into 2 groups, 7-19 year is one group, and 20-69 year is two groups, and 30 every group by the investigation patients.The chilblain tincture that provides with the embodiment of the invention 4 to 6 is executed the chilblain patient and is controlled, and therapeutic effect sees Table 2.
Table 2 chilblain tincture treatment provided by the invention chilblain effect
By table 2 result as can be known, chilblain tincture provided by the invention is 100% to 7～19 years old patient's cure rate, is 93.3% to 20～69 years old patient's cure rate, and obvious effective rate is 6.7%, and total effective rate is 100%.
The chilblain emulsifiable paste that the embodiment of the invention 7 to 9 is provided is executed 1000 chilblain patients and is controlled, and drug effect the results are shown in Table 3.
Table 3 chilblain emulsifiable paste treatment provided by the invention chilblain effect
By table 3 result as can be known, 1000 patients are distinguished according to sex, male patient's 349 examples, female patient 651 examples, the male cures 343 examples, and the women cures 648 examples, always cures 991 examples, and cure rate is 99.1%, total produce effects 9 examples, obvious effective rate is 0.9%.The age-based differentiation, wherein patient's 707 examples of 7～20 years old are cured 707 examples, and cure rate is 100%; 21～70 years old patients, totally 293 examples are cured 284 examples, cure rate 96.9%, produce effects 9 examples, obvious effective rate is 3.1%.Press healing time and distinguish, cured 433 examples in 2～3 days after the drug of topical application, cure 500 examples after 3～5 days, wherein cure 933 examples altogether in 5 days, cure 62 examples after 3～5 days.Press therapentic part and distinguish, the chilblain life is cured 627 examples in patient's 627 examples of women's head-ornaments portion, and cure rate is 100%; The chilblain life is cured 242 examples in patient's 248 examples of hand, and cure rate is 97.58%, produce effects 6 examples, and obvious effective rate is 2.42%; The chilblain life is cured 122 examples in patient's 125 examples of foot, and cure rate is 97.6%, produce effects 3 examples, and obvious effective rate is 2.4%.
Total effective rate is 100%.
In national northwest, southwest, northeast, North China, the southeast, Central China 60 altogether of picked at random every profession and trade personage chilblain patients respectively, the ill time limit 1 year did not wait to 52 years, was divided into 2 groups of indoor and outdoors according to occupation type, 30 every group by the investigation patients; Distinguish according to sex, be divided into 2 groups of male patient and female patients.The chilblain ointment that provides with the embodiment of the invention 10 to 12 is executed the chilblain patient and is controlled, and the results are shown in Table 4.
Table 4 chilblain ointment is to chilblain patient's therapeutic effect
By table 4 result as can be known, chilblain ointment provided by the invention is 100% to office work patient's cure rate; Cure rate to the outside work patient is 96.6%, and obvious effective rate is 3.4%, and total effective rate is 100%.Chilblain ointment provided by the invention is 100% to male patient's cure rate; Cure rate to female patient is 94.7%, and obvious effective rate is 5.3%, and total effective rate is 100%.
The example of the Chinese medicine composition of embodiment 14 treatment chilblain provided by the invention, chilblain tincture, chilblain emulsifiable paste and chilblain ointment treatment chilblain
Case 1:
Name: Seedling, sex: the man, the age: 40 years old, consultation time on January 3rd, 2009, the loader of Suzhou City pharmaceuticals was engaged in indoor and outdoor carrying work for a long time, and wherein face is an ear, and finger all has the chilblain many places.Affected part is red, swell, itch, and scratched inflammation at hand because of pruritus, once uses multiple kibe ointment therebetween, and effect is undesirable, and the chilblain tincture that the application embodiment of the invention 4 provides was itched through coating and to be ended transference cure after 3 days in one time 3 minutes.
Case 2:
Name: Zhu, sex: the man, the age: 56 years old, consultation time December in 2010 7 days, the time paddy building, villages and small towns grade teacher, because of hand frozen mashed, the chilblain tincture that the application embodiment of the invention 5 provides, frozen mashed place after 2 days and just close up, recovery from illness only leaves the pigment vestige after 5 days.
Case 3:
Name: Ma, sex: man, age: 42 years old, consultation time December in 2010 23 days, Ma Dazhuan village in villages and small towns during Suzhou City, builder, hand when examining, facial and step is all frozen swollen, and the hand pruritus has been grabbed mashed, come before the here, once use the medicine of some treating chilblains, all do not feel any better, the chilblain tincture that the application embodiment of the invention 6 provides, itched in 2 days and end, lump disappeared substantially in 5 days, and all symptoms all disappear after 7 days.
Case 4:
Name: Chen, sex: the woman, the age: 39 years old, consultation time on January 5th, 2011, the Southern Pass, Suzhou cotton mill workman, facial many places are frozen pimple, and pain hotness, the chilblain emulsifiable paste that the application embodiment of the invention 7 provides are arranged, pain heat disappeared in 5 minutes, and above symptom all disappears after 3 days, recovery from illness entirely after 7 days.
Case 5:
Name: Lee, sex: woman, age: 38 years old, consultation time December in 2010 8 days, sub-district, Suzhou City Beiyuan, vegetable boss whole seller, face, both hands, all there is chilblain at the back and the position of festering is arranged, every year to winter is frost bitten all, once used several kibe ointments, effect is undesirable, the chilblain emulsifiable paste that the application embodiment of the invention 8 provides, rotten position healing in 3 days, recovery from illness after 7 days.
Case 6:
Name: Wu Huaying, sex: the man, the age: 38 years old, consultation time on November 29th, 2009, Suzhou City Da Ying people from town, construction project manager, respectively there is place's chilblain on facial both sides, and have slightly and fester, blackout, the chilblain emulsifiable paste that the application embodiment of the invention 9 provides, the disappearance of festering after 3 days.Rear face recovered as usual substantially in 5 days, only left some pigmentations.
Case 7:
Name: Hu, sex: man, age: 40 years old, consultation time on November 2nd, 2008, the manager of Suzhou City east celestial bridge chess and card room, face, hand just have chilblain for many years to winter, and pruritus pain, once used several kibe ointments all undesirable, once recurring the Chinese medicine composition of the treatment chilblain that the application embodiment of the invention 1 provides to winter, just recovery from illness after 4 days did not have recurrence in 2 years through following up a case by regular visits to.
Case 8:
Name: Lee, sex: man, age: 50 years old, examine November 27 2007 time, the manager of sales section of Suzhou City food company, owing to do selling operation by motorcycle for a long time, cause face, ear, hands etc. all cold injury, fester, itch, bitterly, hotness all has, every year is protection in advance all, but also is recurrence.The chilblain ointment that the application embodiment of the invention 10 provides, after smearing 2 days, sx, symptom all disappears after 7 days, and following up a case by regular visits to did not all have recurrence in 3 years.
Case 9:
Name: Ma, sex: man, age: 7 years old, consultation time December in 2009 4 days, Suzhou City 12 sophomores of primary school are often played outside by child, cause face, hand all has chilblain, and have and fester, the chilblain ointment that the application embodiment of the invention 11 provides, rotten position just healed in 2 days, symptom disappears after 5 days, recovery from illness after 7 days.
Case 10:
Name: Wang Yan, sex: woman, age: 23 years old, consultation time December in 2008 9 days, the accounting of Suzhou electric company is because from little hand, just there is the root of freezing in foot, annual once occur chilblain to winter, do not show with several kibe ointment effects over several years, behind the chilblain ointment that the application embodiment of the invention 12 provides, itch and end in 3 days affected parts, sx, symptom disappears substantially after 7 days, follows up a case by regular visits to not recurrence in 2 years.
The above only is a preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. a Chinese medicine composition for the treatment of chilblain is characterized in that, is made by following weight portion raw material:
2. the clinical preparation that comprises the described Chinese medicine composition of claim 1.
3. clinical preparation according to claim 2 is characterized in that, it is tincture, emulsifiable paste or ointment.
4. preparation method for the treatment of the Chinese medicine composition of chilblain, it is characterized in that, get the Herba Asari of 5～10 weight portions, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5～10 weight portions, the Fructus Zanthoxyli of 5～10 weight portions, the Ramulus Cinnamomi of 5～10 weight portions, the Radix Angelicae Dahuricae of 5～10 weight portions, the Radix Notoginseng of 5～10 weight portions, the Radix Et Rhizoma Rhei of 5～10 weight portions, the Radix Salviae Miltiorrhizae of 5～10 weight portions, the Radix Aconiti of 5～10 weight portions, the Radix Aconiti Kusnezoffii of 5～10 weight portions, the Radix Glycyrrhizae of 10～20 weight portions, the Flos Genkwa of 10～20 weight portions, the Gypsum Fibrosum Preparatum of 8～10 weight portions, add 600～1000mL decocting after the stirring and boil 30～60min, be cooled to 40～60 ℃, the Camphora that adds 15～30 weight portions, stir postcooling to 20～30 ℃, promptly.
5. according to the Chinese medicine composition of the described preparation method of claim 4 preparation.
6. tincture for the treatment of chilblain, it is characterized in that, its preparation method is a Herba Asari of getting 5～10 weight portions, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5～10 weight portions, the Fructus Zanthoxyli of 5～10 weight portions, the Ramulus Cinnamomi of 5～10 weight portions, the Radix Angelicae Dahuricae of 5～10 weight portions, the Radix Notoginseng of 5～10 weight portions, the Radix Et Rhizoma Rhei of 5～10 weight portions, the Radix Salviae Miltiorrhizae of 5～10 weight portions, the Radix Aconiti of 5～10 weight portions, the Radix Aconiti Kusnezoffii of 5～10 weight portions, the Radix Glycyrrhizae of 10～20 weight portions, the Flos Genkwa of 10～20 weight portions, after the Gypsum Fibrosum Preparatum of 8～10 weight portions is pulverized, priority is 75% and 60% ethanol lixiviate with 200～250mL concentration, the Camphora that adds 15～30 weight portions mixes, promptly.
7. according to the described tincture of claim 6, it is characterized in that the described lixiviate of its preparation method is for soaking 7～15d or soak 48～72h under 50 ℃ of water bath condition at 15～40 ℃.
8. emulsifiable paste for the treatment of chilblain, it is characterized in that, its preparation method is a Herba Asari of getting 5～10 weight portions, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5～10 weight portions, the Fructus Zanthoxyli of 5～10 weight portions, the Ramulus Cinnamomi of 5～10 weight portions, the Radix Angelicae Dahuricae of 5～10 weight portions, the Radix Notoginseng of 5～10 weight portions, the Radix Et Rhizoma Rhei of 5～10 weight portions, the Radix Salviae Miltiorrhizae of 5～10 weight portions, the Radix Aconiti of 5～10 weight portions, the Radix Aconiti Kusnezoffii of 5～10 weight portions, the Radix Glycyrrhizae of 10～20 weight portions, after the Flos Genkwa of 10～20 weight portions is pulverized, decoct, filtering and collecting filter liquid, concentrate the back and add tween 80 6mL, glycerol 10mL, three hexanol amine 2mL are heated to 70～80 ℃, being heated to 70～80 ℃ of solution that obtain with the Bai Fanlin of the stearic acid of 20 weight portions and 40 weight portions mixes, be cooled to 30～55 ℃ of Camphora mixing that add the Gypsum Fibrosum Preparatum and 15～30 weight portions of 8～10 weight portions, promptly.
9. as emulsifiable paste as described in the claim 8, it is characterized in that described decoction is boiled for the decocting that adds 400～500mL respectively; Decoct for the first time 1～3h, decoct 0.6～1.5h for the second time.
10. chilblain ointment, it is characterized in that, its preparation method is heated to 100～120 ℃ for getting 400～800mL animal oil, the Herba Asari that adds 5～10 weight portions, the Pseudobulbus Bletillae (Rhizoma Bletillae) of 5～10 weight portions, the Fructus Zanthoxyli of 5～10 weight portions, the Ramulus Cinnamomi of 5～10 weight portions, the Radix Angelicae Dahuricae of 5～10 weight portions, the Radix Notoginseng of 5～10 weight portions, the Radix Et Rhizoma Rhei of 5～10 weight portions, the Radix Salviae Miltiorrhizae of 5～10 weight portions, the Radix Aconiti of 5～10 weight portions, the Radix Aconiti Kusnezoffii of 5～10 weight portions, the Radix Glycyrrhizae of 10～20 weight portions, fry in shallow oil after the Flos Genkwa of 10～20 weight portions stirs and press 30～50min, be cooled to 40～60 ℃, add the Camphora of 15～30 weight portions and the Gypsum Fibrosum Preparatum of 8～10 weight portions, stir postcooling to 20～30 ℃, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110247677 CN102293931B (en) | 2011-08-24 | 2011-08-24 | Traditional Chinese medicinal composition, clinical preparation and preparation methods thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110247677 CN102293931B (en) | 2011-08-24 | 2011-08-24 | Traditional Chinese medicinal composition, clinical preparation and preparation methods thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102293931A true CN102293931A (en) | 2011-12-28 |
| CN102293931B CN102293931B (en) | 2013-01-09 |
Family
ID=45354764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110247677 Expired - Fee Related CN102293931B (en) | 2011-08-24 | 2011-08-24 | Traditional Chinese medicinal composition, clinical preparation and preparation methods thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102293931B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393951A (en) * | 2013-08-14 | 2013-11-20 | 王玉华 | Chilblain tincture |
| CN103656581A (en) * | 2013-12-11 | 2014-03-26 | 山东中大药业有限公司 | Traditional Chinese medicine composition for treating chilblain and preparation method thereof |
| CN104056114A (en) * | 2014-07-18 | 2014-09-24 | 郑志保 | Traditional Chinese medicine preparation for treating chilblain |
| CN104815044A (en) * | 2015-04-26 | 2015-08-05 | 肖祥宇 | Medicine for treating chilblain and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721663A (en) * | 2008-10-30 | 2010-06-09 | 宋修芳 | Traditional Chinese medicine for treating chilblains |
-
2011
- 2011-08-24 CN CN 201110247677 patent/CN102293931B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721663A (en) * | 2008-10-30 | 2010-06-09 | 宋修芳 | Traditional Chinese medicine for treating chilblains |
Non-Patent Citations (2)
| Title |
|---|
| 《解放军药学学报》 20011030 刘锁兰等 中药治疗非冻结性冻伤的研究进展 270-272 1-10 第17卷, 第05期 * |
| 《辽宁中医药大学学报》 20080605 何英 中医药治疗冻疮进展 86-87 1-10 第10卷, 第06期 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393951A (en) * | 2013-08-14 | 2013-11-20 | 王玉华 | Chilblain tincture |
| CN103393951B (en) * | 2013-08-14 | 2015-03-04 | 王玉华 | Chilblain tincture |
| CN103656581A (en) * | 2013-12-11 | 2014-03-26 | 山东中大药业有限公司 | Traditional Chinese medicine composition for treating chilblain and preparation method thereof |
| CN103656581B (en) * | 2013-12-11 | 2016-06-08 | 王欣 | The Chinese medicine composition for the treatment of pernio and preparation method |
| CN104056114A (en) * | 2014-07-18 | 2014-09-24 | 郑志保 | Traditional Chinese medicine preparation for treating chilblain |
| CN104815044A (en) * | 2015-04-26 | 2015-08-05 | 肖祥宇 | Medicine for treating chilblain and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102293931B (en) | 2013-01-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102579701B (en) | Compound dandelion decoction | |
| CN104208245A (en) | Traditional Chinese medicine medicated bath for tinea of feet and hands and preparation method thereof | |
| CN102293931B (en) | Traditional Chinese medicinal composition, clinical preparation and preparation methods thereof | |
| CN103386022A (en) | Chinese medicine composition for treating tuberculous pleurisy | |
| CN111840416A (en) | Marrow-washing bone-setting liquid | |
| CN104940886A (en) | External preparation for treating seborrheic alopecia and preparing method thereof | |
| CN104324310A (en) | Traditional Chinese medicine composition for treating mycotic keratitis after immune suppression and preparation method thereof | |
| CN106729100A (en) | With anti-inflammatory, the external application Chinese medicine health care preparation of beauty and preparation method thereof | |
| CN105999166A (en) | Formula and preparation method of traditional Chinese medicine for treating chilblain | |
| CN112691157A (en) | Formula and preparation method of medicinal material composition for treating rheumatic arthritis | |
| CN101934016B (en) | External medicament for treating arthritis | |
| CN111803564A (en) | Collateral-dredging liquid for dredging collaterals and relaxing tendons | |
| CN103055137B (en) | Traditional Chinese medicine for treating chronic pancreatitis | |
| CN108714167B (en) | A Chinese medicinal preparation for external use for treating vitiligo, and its preparation method | |
| CN105641226A (en) | Hot-compress salt for treating dysmenorrhea and preparation method | |
| CN105213749A (en) | Be used for the treatment of osteoporotic preparation and method for making | |
| CN104490705A (en) | Foot bath liquid | |
| CN104888105A (en) | Traditional Chinese medicine for treating primary liver cancer | |
| CN104606638A (en) | Medicine for treating damp-heat type acute eczema and preparation method thereof | |
| CN102895474B (en) | Powder for treating chloasma and preparation method for powder | |
| CN112057527A (en) | A Chinese medicinal hot topical plaster for treating pain and bone injury, and its preparation method | |
| CN102895475B (en) | Plaster for treating chloasma and preparation method thereof | |
| CN114344434A (en) | Traditional Chinese medicine composition for treating pulmonary nodules and preparation method thereof | |
| CN109529062A (en) | A kind of Ultrasonography novel couplant | |
| CN101401881A (en) | Chinese medicinal composition for treating poison produced by venomous insects |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: STATE GRID CORPORATION OF CHINA Free format text: FORMER OWNER: MA LIANGHAI Effective date: 20140416 Owner name: XINXIANG POWER SUPPLY COMPANY, STATE GRID HENAN EL Effective date: 20140416 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 234000 SUZHOU, ANHUI PROVINCE TO: 100031 XICHENG, BEIJING |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20140416 Address after: 100031 Xicheng District West Chang'an Avenue, No. 86, Beijing Patentee after: State Grid Corporation of China Patentee after: Xinxiang Power Supply Company, State Grid Henan Electric Power Company Address before: 234000 Anhui city of Suzhou Province towns Village Ma Wang Group Yongqiao Area No. 71 Patentee before: Ma Lianghai |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130109 Termination date: 20150824 |
|
| EXPY | Termination of patent right or utility model |