CN104324310A - Traditional Chinese medicine composition for treating mycotic keratitis after immune suppression and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating mycotic keratitis after immune suppression and preparation method thereof Download PDF

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CN104324310A
CN104324310A CN201410330371.6A CN201410330371A CN104324310A CN 104324310 A CN104324310 A CN 104324310A CN 201410330371 A CN201410330371 A CN 201410330371A CN 104324310 A CN104324310 A CN 104324310A
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parts
radix
chinese medicine
medicine composition
blood
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CN104324310B (en
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张红敏
郑宏
郑攀
郑启仲
王丽英
安利娜
黄霄
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Henan provincial Eye Hospital
Henan Provincial Peoples Hospital
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张红敏
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Abstract

The invention discloses a traditional Chinese medicine composition for treating mycotic keratitis after immune suppression and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises 23 Chinese herbal medicine compatibility components comprising radix astragali preparata, codonopsis pilosula, roasted rhizoma atractylodis macrocephalae, rehmannia glutinosa and the like. As for symptoms of spleen and kidney deficiency, deficiency of both qi and yin and wet and hot blood stasis after an immune suppressor is applied, the traditional Chinese medicine composition has the beneficial effects of tonifying kidney and spleen, tonifying qi and yin, clearing heat and promoting dieresis, activating blood and removing stasis; and as for root causes of fungus toxin infecting, the medicines for killing fungi are mainly used for clearing away heat and toxic materials. According to the overall policy, both symptoms and root causes of complex pathogenesis can be treated. Use of the traditional Chinese medicine composition has the advantages that body resistance strengthening and evil eliminating are carried out at the same time to prevent the body from being injured by the evil; the kidney and the spleen are tonifyed at the same time so that the bermorgen is tonifyed and congenital factors are benefited; warm and cold are used at the same time so that the overall formula is warm without drying and clear without cold; blood enriching is carried out while blood circulation invigorating is carried out, and stasis removing is carried out while the blood is not injured; and the use of the medicine composition meets the requirement of traditional Chinese medicine theories, is supported by modern pharmacology studying, and finally the traditional Chinese medicine composition is efficient and gentle.

Description

A kind ofly be used for the treatment of Chinese medicine composition of fungal keratitis after immunosuppressant and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition being used for the treatment of fungal keratitis after immunosuppressant, and the preparation method of this Chinese medicine composition, belong to technical field of Chinese medicine.
Background technology
Cornea fungal infection is a kind of common clinically blinding, infectious eye disease, is to infect cornea by pathomycete to cause, and being the main cause of China's suppurative keratitis and corneal transplantation, is the first cause of disease of corneal blindness.This disease be clinical ophthalmology doctor often faced by, the state of an illness is dangerous, but the disease that treatment is very thorny.Mainly because the treatment for fungus is natively more difficult, the special construction of cornea and eye table barrier, make antifungal drug be difficult to penetrate into cornea inside in addition, and therefore, fungal keratitis is the very difficult a kind of keratitis of clinical treatment.Greatly patient because of the state of an illness uncontrollable, finally need corneal transplantation, due in great shortage at China's corneal donor, so a part of patient is for preventing disease progression, has to carry out eyeball excise, finally causing blind.Therefore, fungal keratitis has become China's ophthalmic industry important scientific problems urgently to be resolved hurrily.
The cause of disease of fungal keratitis is a lot, have vegetalitas wound, corneal contact lens worn, corticosteroid hormone and immunosuppressant use after immunosuppressive condition cause.It is fungal infection under normal immunological state that vegetalitas wound, corneal contact lens wear the fungal keratitis caused, and application antifungal drug is treated.And the cornea fungal infection that corticosteroid hormone and immunosuppressant use rear immunosuppressive condition to cause, immune status is abnormal is main cause, though clinical treatment is very thorny, immune state recovers normal, and Opportunistic Pathogen Infection is removed naturally.Chinese medicine compound regulates in whole body function and has superiority very much in immunomodulating.But still do not find at present the document of the Chinese medicine compound of the fungal keratitis caused for immunosuppressant, report or publication.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition being used for the treatment of fungal keratitis after immunosuppressant.
Meanwhile, the present invention also provides a kind of preparation method being used for the treatment of the Chinese medicine composition of fungal keratitis after immunosuppressant.
In order to realize above object, the technical solution adopted in the present invention is:
A kind of Chinese medicine composition being used for the treatment of fungal keratitis after immunosuppressant, be made up of the raw material of Chinese medicine of following parts by weight: Radix Astragali Preparata 9 ~ 30 parts, Radix Codonopsis 9 ~ 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 6 ~ 12 parts, Rhizoma Atractylodis (parched) 3 ~ 9 parts, 9 ~ 15 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 15 ~ 30 parts, Fructus Lycii 6 ~ 12 parts, Fructus Ligustri Lucidi 6 ~ 12 parts, Semen Armeniacae Amarum 6 ~ 9 parts, roud cardamon seed 3 ~ 6 parts, Semen Coicis 9 ~ 30 parts, Herba Lophatheri 6 ~ 12 parts, Cortex Magnoliae Officinalis 3 ~ 9 parts, Flos Lonicerae 6 ~ 12 parts, Flos Chrysanthemi Indici 9 ~ 15 parts, Herba Taraxaci 9 ~ 15 parts, the Radix Paeoniae Alba 6 ~ 15 parts, Radix Angelicae Sinensis 6 ~ 12 parts, Rhizoma Chuanxiong 3 ~ 9 parts, 3 ~ 9 parts, Flos Carthami, Radix Saposhnikoviae 6 ~ 9 parts, Radix Bupleuri 3 ~ 9 parts, 3 ~ 9 parts, Radix Glycyrrhizae.
Each crude drug effect is summarized as follows:
The Radix Astragali: be the root of pulse family Astragalus Radix Astagali and Radix Astragali; Containing saponin component as astragaloside, isoflavones components is as calycosin, and fatty acid is as Palmic acid and linoleic acid, and polysaccharide is as astragalus polysaccharides, heteropolysaccharide etc., and nearly 20 various trace elements; Radix Astragali sweet in the mouth, warm in nature, return lung, spleen channel; Energy benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening; Cure mainly the disease of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, bursts to carbuncle difficulty or bursts for a long time and do not hold back person's excellent.The modern pharmacology research of the Radix Astragali is shown: 1) astragalus polysaccharides is most important natural constituent in the Radix Astragali, astragalus polysaccharides can improve immune function of human body, strengthens cell physiological metabolism, improves macrophage activity, it can strengthen immune organ weight, promotes T and bone-marrow-derived lymphocyte conversion ratio.Also report astragalus polysaccharides is had to stimulate Mus bone-marrow-derived lymphocyte and macrophage.Astragalus polysaccharides also can promote plasma cell hypertrophy and antibody synthesis, strengthen humoral immunization, all obviously can promote that NK cells in mice is active with external in vivo, stimulate NK cell proliferation, the more important thing is that astragalus polysaccharides can work in coordination with interleukin II effect, make NK cytoactive and stimulate the effect of NK cell proliferation to significantly improve, all have good preventive and therapeutic effect to panimmunity Defects such as acquired immune deficiency syndrome (AIDS).2) Radix Astragali also has antifungic action.Therefore, no matter from basic theory of tcm, or modern study, the Radix Astragali is immunity moderation not only, also has antifungic action, is the fit closely Chinese medicine of fungal keratitis after treatment immunity.
Radix Astragali Preparata: Radix Astragali (processed with Mel), inclined tab cut by the Radix Astragali, Mel is put in pot, slow fire boils, and (the sweet droplet of fusing enters in cold water, can form soft pearl ball, degree of raw and cooked differentiates according to color), add a little boiled water dilution Mel stickiness, put into astragalus mongholicus tablet and stir, fry and penetrate the sheet heart to Mel juice, moisture fried dry is degree.Radix Astragali (processed with Mel) adds the benefiting action of the Radix Astragali, is more longer than qi-supplementing, blood-engendering.
Radix Codonopsis: be the root of campanulaceae Codonopsis plant Radix Codonopsis, element flower Radix Codonopsis, radix codonpsis tangshen, pipe flower Radix Codonopsis, C. subglobosa, C. canescens; Containing saccharide as fructose, inulin, polysaccharide and 4 kinds of heteropolysaccharide CP 1, CP 2, CP 3, CP 4glycoside is as ligustrin, n-hexyl-β-pyranglucoside, ethyl-α-D-fructofuranoside, tangshenoside, alkaloid and nitrogen containing component, as choline, loline etc., also contain the various active compositions such as syringic aldehyde, vanillic acid, pyromucic acid, atractyloide I, II; Radix Codonopsis sweet in the mouth, property is put down, and returns spleen, lung meridian; Energy strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid; Cure mainly weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung are breathed with cough, all cards of spontaneous perspiration of breathing hard, deficiency of both QI and blood; Modern pharmacology proves that Radix Codonopsis has enhancing body stress ability, enhancing human body immunity function, slow down aging, antiulcer, antitumor action etc.There is bibliographical information Radix Codonopsis can significantly improve the phagocytic index of Turnover of Mouse Peritoneal Macrophages, there is immunological enhancement.
The Rhizoma Atractylodis Macrocephalae: be the rhizome of the Compositae [WTBX plant Rhizoma Atractylodis Macrocephalae; Containing volatile oil as atractylone, α and β-Humuleno, α-curcumene, Palmic acid, hinesol etc., sesquiterpene lactones compound is as atractyloide-I, II, III, IV etc., polyacetylene alcohol compound, also containing scopoletin, there is immunocompetent mannan AM-3, and more than ten seed amino acid such as aspartic acid, serine; Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, warm in nature, return spleen, stomach warp; Can invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive; Cure mainly weak, the lack of appetite abdominal distention of deficiency-weakness of spleen-QI, have loose bowels, constipation, fluid-retention stagnating in the interior dysuria, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI etc.; Modern pharmacology proves the effects such as the Rhizoma Atractylodis Macrocephalae has antioxidation and slow down aging, antitumor, blood sugar lowering, diuresis and anti-ascites, protects the liver, function of gallbladder promoting, can also facilitating digestion system, immune system, cardiac muscle and cardiovascular system.Have bibliographical information, the Rhizoma Atractylodis Macrocephalae is by activating T, bone-marrow-derived lymphocyte function and breeding its cell quantity, thus enhancing body humoral immunization and cellular immune function.
Rhizoma Atractylodis Macrocephalae (parched): be sprinkled into by processed with honey wheat bran in hot pot, add Rhizoma Atractylodis Macrocephalae sheet in time smoldering, fry to coke yellow, effusion burnt odor gas, take out, sieve removes processed with honey wheat bran.Every 100kg Rhizoma Atractylodis Macrocephalae sheet, with processed with honey wheat bran 10kg.Rhizoma Atractylodis Macrocephalae (parched) shape as the Rhizoma Atractylodis Macrocephalae, surperficial yellowish-brown, accidental focal spot, somewhat burnt odor gas, mildly bitter flavor.Rhizoma Atractylodis Macrocephalae (parched) can relax dry property, in entering, can strengthen spleen invigorating, detumescence effect by means of bran.
Rhizoma Atractylodis: be the rhizome of Compositae [WTBX plant Atractylodes lancea (Thunb.) DC., Atractylis chinensis, atractylodes japonica; Containing volatile oil as β-Fructus Canarii albi alkene, chamigrene, Flos Caryophylli alkene, elemene etc., the various active compositions such as hemiterpene glucosides class, alkynes alkene class, also containing inorganic elementss such as cobalt, chromium, copper, manganese, molybdenums; Acrid in the mouth, hardship, warm in nature, return spleen, stomach, Liver Channel; Can drying damp and strengthening spleen, wind-damp dispelling, improving eyesight; Cure mainly the spleen and stomach being stranded by dampness, asthenia drowsiness, feeling of stuffiness in chest abdominal distention, inappetence, vomiting are had loose bowels, phlegm retention, damp-edema, exterior syndrome folder is wet, head heavy sensation of the body pain, arthromyodynia domination of damp pathogen, podomere ache and weigh; Modern pharmacology proves that Rhizoma Atractylodis have anti-hypoxia, diuresis, arrhythmia, antibacterial, antivirus action etc.Have bibliographical information: the grey stilbene be made up of Rhizoma Atractylodis, the Radix Astragali is dispersed in and humoral immunization can be made significantly to strengthen, and serum antibody titer improves greatly, antibody life period extends, and T lymhocyte transformation rate is also improved to some extent simultaneously.In addition, Rhizoma Atractylodis have antifungic action, and Rhizoma Atractylodis leachate can cause fungal cell wall and cell interior structural deterioration.
Rhizoma Atractylodis (parched): have another name called parched with bran Rhizoma Atractylodis, concocting method: get clean Rhizoma Atractylodis sheet, put in pot, fry to surperficial micro-yellow with slow fire, taking-up cools, and shape is as Rhizoma Atractylodis sheet.This product shape is as Rhizoma Atractylodis sheet, and surperficial buff, loose have most sepia grease chamber.There is burnt odor gas.Rhizoma Atractylodis (parched) property of medicine milder, strengthens the spleen strengthening and damp drying effect of Rhizoma Atractylodis.
Radix Rehmanniae Preparata: be the Preparation process product (Radix Rehmanniae is the tuber of Scrophulariaceae Radix Rehmanniae platymiscium Radix Rehmanniae, admixes yellow wine in Radix Rehmanniae, steams to well-done in black, the obtained Radix Rehmanniae Preparata of section) of Radix Rehmanniae.Radix Rehmanniae Preparata sweet in the mouth, slightly warm in nature, returns liver, kidney channel, can enrich blood yin nourishing, life essence-filling, marrow-benefitting.Be mainly used in the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Radix Rehmanniae Preparata is containing a small amount of iridoid constituents, be separated and obtained Herba Leonuri glycoside, aucubin, Rehmannioside A, B, C, D etc., again containing monoterpene composition, as burnt rehmanin A, B, C, burnt Radix Rehmanniae lactone etc., also containing aminoacid, (its composition compares with Radix Rehmanniae, not containing lysine, and all corresponding minimizing of content), and saccharide (wherein the content of monosaccharide is than more than the many twice of Radix Rehmanniae).Modern pharmacological research shows, and redemption behavior can improve mouse macrophage phagocytic index, and Radix Rehmanniae Preparata crude polysaccharides can strengthen the expression of T lymphocyte Th1 and Th2 cytokine, has the effect improving immune function of mice.
Rhizoma Dioscoreae: be the tuber of Dioscoreaceae yam Rhizoma Dioscoreae; Tuber contains diosgenin, dopamine, hydrochloric acid Rhizoma Dioscoreae alkali, allantoin, only wooden fork element II, also containing the aminoacid such as cystine, γ-aminobutyric acid, and Chinese yam polysaccharide, the various trace elements etc. such as barium, beryllium, cerium, cobalt, rhizome contains sterols as cholesterol, ergosterol, campesterol, stigmasterol, cupreol etc., containing phytic acid, mannocarolose I a, I b and I c in mucus; Rhizoma Dioscoreae sweet in the mouth, property are flat, return spleen, lung, kidney channel; Can spleen reinforcing, support lung, reinforce the kidney, benefit essence; Cure mainly diarrhea due to hypofunction of the spleen, lack of appetite edema, cough and asthma due to lung deficiency, quench one's thirst, frequent micturition etc. of suffering from a deficiency of the kidney; Modern pharmacology proves that Rhizoma Dioscoreae has the effects such as blood sugar lowering, blood fat reducing, antioxidation, can also facilitating digestion system and immunologic function.Bibliographical information, Chinese yam polysaccharide has immunoregulatory activity, can promote the phagocytic function of reticuloendothelial system, strengthens Execution, activating phagocytic cells, the expression of the induction of immunity factor, strengthens the immune function such as macrophage, lymphocyte.
Fructus Lycii: for Fructus Lycii is the fruit of Solanaceae Lycium lycium barbarum; Containing various active compositions such as Allylamines, polysaccharide, cerebroside, ursolic acid, alkaloid, P-coumaric acid, daucosterol, carotene, atropine, hyoscyamine, Semen Maydis xanthin, physalin, kryptoxanthin, vitamin Cs; Sweet in the mouth, property are flat, return liver, kidney, lung meridian; Energy nourishing the liver, nourishing kidney, lung moistening; Cure mainly caused by liver and kidney deficiency, have a dizzy spell, visual unclear, soreness of the waist and knees, cough due to consumptive disease etc.; Modern pharmacology proves that Fructus Lycii has the effect such as slow down aging, anti-fatty liver, adjusting blood lipid and blood glucose, promotion hemopoietic function, can also conditioner body immunity function, effective Tumor suppression growth and cell mutation etc.Test proves, Fructus Lycii, by activating T, bone-marrow-derived lymphocyte function and breeding its cell quantity, improves IgA, IgG content and increases antibody-producting cell number and antibody titer, thus enhancing body humoral immunization and cellular immune function.
Fructus Ligustri Lucidi: be the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi; Containing triterpenes as oleanolic acid, acetyloleanolic acid, ursolic acid, acetyl ursolic acid, phenolic glycoside class is as p-hydroxyphenylethanol, Syring vulgaris phenolic glycoside etc., iridoid glycosides is as nuzhenide, oleuropein, different nuzhenide etc., also contain flavonoid as raceme eriodictyol, Quercetin etc., and fatty acid is as Palmic acid, oleic acid etc., phospholipid is as LYSO-PHOSPHATIDYLCHOLINE LYSOPC, PHOSPHATIDYL ETHANOLAMINE etc., and volatile oil is as various active compositions such as thioacetones; Sweet in the mouth, hardship, cool in nature, return liver, kidney channel, energy liver and kidney tonifying, clearind deficient heat, improving eyesight; Cure mainly Light-headedness, soreness of the waist and knees, tinnitus, early whitening of beard and hair, osteopyrexia and fever etc.; Modern pharmacology proves that Fructus Ligustri Lucidi has antiinflammatory, blood sugar lowering, protects the liver, antimutagenesis etc.Bibliographical information; Fructus Ligustri Lucidi has potentiation to Nonspecific immunity; promote lymphocytic propagation, strengthen the phagocytic function of macrophage; and have synergism with interleukin II; the specific cellular immunity of normal mouse is had no significant effect; all obviously can suppress the rising of the micronuclei in mice cell number that cyclophosphamide and urethane cause, thus certain protective role is played to the damage of cell chromosome.Fructus Ligustri Lucidi still has the effect of anti-deep fungal.
Semen Armeniacae Amarum: be the seed of Rosaceae Fructus Pruni platymiscium Fructus Pruni, wild apricot, Prunus armeniaca L.var.ansu Maxim., prunus mandshuricaKoehne; Containing bitterness cyanogen glycosides, phenolic ester class as amygdaloside, Virginia prune glucoside etc., fatty oils is as linoleic acid, oleic acid, Palmic acid etc., phenolic acids is as chlorogenic acid, neochlorogenic acid etc., protein component is as KR-A, KR-B etc., and the volatile ingredient relevant with almond flavor is as the plurality of active ingredients such as benzaldehyde, linalool; Semen Armeniacae Amarum bitter in the mouth, slightly warm in nature, return lung, large intestine channel; Energy lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, loosening bowel to relieve constipation; Cure mainly the disease such as exogenous cough's dyspnea with fullness of the chest, dryness of the intestine constipation; Modern pharmacology proves that Semen Armeniacae Amarum has the effects such as relieving cough and asthma, antitumor, antiinflammatory, analgesia, has regulating action to digestive system.
Roud cardamon seed (Fructus Amomi Rotundus, Fructus Amomi Rotundus): be the mature fruit of Zingiberaceae Amomum plant Fructus Amomi Rotundus and melon Fructus Amomi Rotundus; Seed is containing volatile oil, what wherein component content was the highest is 1,8-cineole 66.87%, relatively high has nopinene 10.93%, australene 3.71%, Flos Caryophylli alkene 3.01%, Borneolum Syntheticum acetas 2.04%, alpha-terpineol 2.03%, linalool 1.39%, in addition containing 4-terpinenol, aromadendrene, γ-patchoulene, α-elemene, γ-cubebene, aquation sabinene, nerolidol, bisabolence, camphene and Eucarvone etc.; Acrid in the mouth, warm in nature, return lung, spleen, stomach warp; Energy removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, appetite-stimulating indigestion-relieving; Cure mainly retention of damp leading to blockage of QI, incoordination between the spleen and stomach, distension and fullness in the abdomen, anorexia, hygropyrexia from the beginning of, not hungry, gastrofrigid vomiting, food stagnation uncomfortable in chest do not disappear; Modern pharmacology proves that roud cardamon seed has tuberculosis effect, can affect the activity etc. of ethanol dehydrogenase.
Semen Coicis (Semen Coicis): be the kernel of grass family Coix plant Semen Coicis; Containing coixenolide as triacylglycerol, diacylglycerol, monoacylglycerol, sterol ester, free fatty etc., its free fatty acid comprises linoleic acid, Palmic acid, stearic acid, cis-8-octadecenic acid etc., also containing glucose, acidic polysaccharose C a-1, C a-2and Semen Coicis Polysaccharide A-C, volatile oil is as hexanal, caproic acid, sad, the various active composition such as ethyl palmitate, methyl linoleate, vanillin and Ethyl linoleate; Sweet in the mouth, light, cold nature, returns spleen, stomach, lung meridian; The spleen invigorating of energy dampness removing, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus; Cure mainly edema, beriberi, dribbling urination, damp-warm diseases, have loose bowels, leukorrhagia, rheumatic arthralgia, the contracture of muscle arteries and veins, lung abscess, acute appendicitis etc.; Modern pharmacology proves the effects such as Semen Coicis has antitumor, suppresses Skeletal Muscle Contraction, analgesia, antipyretic, antiinflammatory, blood sugar lowering, enhancing immunity.The Semen Coicis oil extracted from Semen Coicis has antitumor, enhancing immunity and improves the effects such as cachexia.
Herba Lophatheri (Folium Bambusae): be the leaf of grass family Phyllostachys plant phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle etc.; Containing alkaloid, aminoacid, organic acid, phenolic compound and tannin, saponin, reducing sugar, protein, polysaccharide and glycoside, anthraquinone, coumarin and terpene lactone compound, steroidal, also contain 18 kinds of elements as aluminum, barium, zirconium, titanium, lead, stannum, gallium, strontium, ferrum, zinc, magnesium, calcium, manganese, nickel, copper, silver and boron and silicon; Sweet in the mouth, light, cold in nature, GUIXIN, lung, stomach warp; Can clearing heat and relieving fidgetness, promote the production of body fluid, diuresis; Cure mainly calentura excessive thirst, pediatric epilepsy scared, cough with dyspnea tell nosebleed, oliguria with reddish urine, erosion of the oral mucosa tongue boil; Modern pharmacology proves that Folium Bambusae has antitumor, adjusting blood lipid, antioxidation etc.
Cortex Magnoliae Officinalis: be the bark of Magnoliaceae anil Cortex Magnoliae Officinalis and Mount Lushan Cortex Magnoliae Officinalis, root bark and branch skin; Containing lignanoids as magnolol, the new phenol of Cortex Magnoliae Officinalis, Cortex Magnoliae Officinalis aldehyde B, C etc., monoterpene lignanoids is as Mentha piperita base magnolol, two Mentha piperita base magnolol, Cortex Magnoliae Officinalis triphenol etc., two lignanoids is as Cortex Magnoliae Officinalis lignan F, G, H and I, alkaloids is as magnocurarine, salicifoline, more than 30 kind of volatile oil, as sagittol, to P-cymene etc., also contains the various active such as sinapyladehyde, syringaresinol composition; Cortex Magnoliae Officinalis bitter in the mouth, pungent, warm in nature, return stomach, large intestine channel; Energy circulation of qi promoting intestinal stasis relieving, dampness, lowering the adverse QI to relieve asthma; Cure mainly stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, expectorant stops up QI rising in reverse order, fullness in the chest is breathed with cough; Modern pharmacology proves that Cortex Magnoliae Officinalis has the effects such as antiulcer, disease-resistant rovitamin, anti-inflammatory and antalgic, antitumor, anticoagulant.
Flos Lonicerae: be the alabastrum of Caprifoliaceae woodbine Radix Ophiopogonis, Lonicera confusa, wild rice gland Radix Ophiopogonis, Lonicera fulvotnetosa Hsu et S. C. Cheng. Ms; Containing phenolic acids as chlorogenic acid, isochlorogenic acid, sterols is as cupreol, and volatile oil is as linalool, ethyl palmitate, ethyl linolenate etc., and flavonoid is as plurality of active ingredients such as luteoloside, xylostein, hyperins; Flos Lonicerae sweet in the mouth, cold in nature; Attach to the lung and stomach meridians; Energy heat-clearing and toxic substances removing; Cure mainly affection due to external wind and heat or epidemic febrile disease heating, heatstroke, toxic-heat and blood stasis, carbuncle furuncle, sore throat, multi-infection disease etc.; Modern pharmacology proves that Flos Lonicerae has the effects such as resisting pathogenic microbes, antitoxin, antiinflammatory, blood fat reducing.In addition, Flos Lonicerae polysaccharide has obvious immunological enhancement, and drug effect is relevant with dosage.It is active that Flos Lonicerae extract has antifungal (candida albicans bacterium, Candida tropicalis, Candida glabrata).
Flos Chrysanthemi Indici: be the flower of Compositae Dendranthema Herba Dendranthematis indici; Containing yejuhua lactone, chrysanthemol, chrysanthetriol, Flos Chrysanthemi Indici ketone, chrysanthenone, cis-helicene alcohol ether, trans-helicene alcohol ether, Radix Angelicae Sinensis acyl ambrosin B, Radix Angelicae Sinensis acyl sub-centautin, Scotland artemisin A, robinin, luteolin, chrysanthemaxanthin, daucosterol, ambrosin A, Palmic acid, ursolic acid, linoleic acid etc., also containing linarin; Bitter in the mouth, pungent, cool in nature, return lung, Liver Channel; Energy heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver; Cure mainly furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, headache, dizzy etc.; Modern pharmacology proves that Flos Chrysanthemi Indici has antibacterial, antitumor, antioxidation, removing toxic substances, blood pressure lowering and enhancing human body immunity effect etc.Bibliographical information, Flos Chrysanthemi Indici Polysaccharides On Cyclophosphamide induced mice immunologic hypofunction has protective effect.In addition, Flos Chrysanthemi Indici also has Antifungal action.
Herba Taraxaci: for Compositae Dandelion plant dandelion, alkali ground Herba Taraxaci, Herba Taraxaci ohwiani, different luxuriant Herba Taraxaci, Taraxacum asiatica Dahlst, Taraxacum erythropodium Kifag etc. belong to the herb of various plants together; Containing taraxasterol, choline, inulin, pectin, apigenin, rutin etc., also contain volatile oil as various active compositions such as hexanol, Camphora, n-octyl alcohols; Bitter in the mouth, sweet, cold in nature, return liver, stomach warp; Energy heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation; Cure mainly acute mastitis, lung abscess, acute appendicitis, mumps, scrofula, furuncle carbuncle toxin, conjunctival congestion and swelling pain, cold, fever, cough, laryngopharynx swelling and pain, gastritis, dysentery, hepatitis, cholecystitis, urinary tract infection, snake bite and insect sting, burn and scald etc.; Modern pharmacology proves that Herba Taraxaci has resisting pathogenic microbes, antiendotoxin, antitumor, anti-gastric-ulcer, function of gallbladder promoting, protects the liver and the effect such as immunity moderation.The Chinese medicine compound of the composition such as the Radix Astragali, Herba Taraxaci has activation to immunocyte, can promote the lymphocytic conversion ratio of T.In addition, Herba Taraxaci still has inhibitory action to fungus.
The Radix Paeoniae Alba: be the root of Paeoniaceae Paeonia plant peony (cultivation product) and Peony; Containing iridoid glycosides as peoniflorin, oxypaeoniflorin, benzoylpaeoniflorin, albiflorin etc., sterols is as cupreol, daucosterol, tannin is as 1,2,3,6-tetra-galloyl glucose, gallic acid, cianidanol etc., also containing volatile oil such as benzoic acid, paeonol and other alcohols, phenols component isoreactivity composition; Bitter in the mouth, acid, cold nature, returns liver, spleen channel; Can nourish blood and seek, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver; Cure mainly blood deficiency cold and heat, epigastric pain, hypochondriac pain, limb spasm pain, dysmenorrhea, menoxenia, metrorrhagia, spontaneous perspiration, night sweat, dysentery had loose bowels, have a headache dizzy etc.; Modern pharmacology proves that the Radix Paeoniae Alba has antiinflammatory, analgesia, resisting pathogenic microbes, antimutagenic, antitumor, resisting oxygen lack etc.Bibliographical information, Radix Paeoniae Alba total glucosides has immunological enhancement, also has the anti-oral Candida of energy, has antifungal potential applicability in clinical practice.
Radix Angelicae Sinensis: be the root of Umbelliferae archangel Radix Angelicae Sinensis; Containing multiple volatile oil and organic acid, also containing more than 20 kind of inorganic elements and polysaccharide composition; Sweet in the mouth, pungent, bitter, warm in nature, return liver, the heart, spleen channel; Can enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation; Cure mainly all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea ， mass in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down etc.; Modern pharmacology proves that Radix Angelicae Sinensis can affect blood and hemopoietic system, has the effects such as blood fat reducing, arteriosclerosis, radioprotective, antitumor, anti-inflammatory and antalgic and antibody Monoclonal.Bibliographical information, Radix Angelicae Sinensis polysaccharide extremely significantly or can significantly improve Turnover of Mouse Peritoneal Macrophages and NK cytoactive, makes mice spleen lymphocytes proliferation, all has obvious restitution to the immunosuppressive condition that chemical factor causes as immunosuppressant and antitumor drug.
Rhizoma Chuanxiong: be the rhizome of Umbelliferae Ligustrum plant Rhizoma Chuanxiong; Containing ligustrazine, loline or perlolyrine etc., also containing two phthalide-type, phenolic acids is as foreign Rhizoma Chuanxiong quinone, 4-HBA, vanillic acid, caffeic acid, protocatechuic acid etc., and volatile oil is as various active compositions such as ligustilide, 3-butylidenephthalide, sabinenes; Acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel; Energy blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping; Cure mainly that menoxenia, amenorrhea dysmenorrhea, the stasis of blood in puerperal stagnant stomachache, mass in the abdomen lump, pain in chest and hypochondrium, headache are dizzy, anemofrigid-damp arthralgia, traumatic injury, ulcer sores etc.; Modern pharmacology proves that Rhizoma Chuanxiong has protection facilitation to cardio-cerebrovascular, blood system, immune system etc., and energy antithrombotic, improves hemorheologic parameters.In recent years, ligustrazine comes into one's own in the effect of Organism immunoregulation and anti-tumor aspect, numerous research display, ligustrazine energy enhancing human body immunity function, at nerve immunity, blood system, autoimmune disease, antitumor and in inflammatory mediator etc., all there is immunoregulation effect, all there is good facilitation to aspects such as Cellular Immunity, humoral immunization and nonspecific immunities.In addition, Rhizoma Chuanxiong also has anti-deep fungal effect.
Flos Carthami: be the flower of Compositae Flos Carthami platymiscium Flos Carthami; Containing flavone compound as saffloside, front saffloside, safflower yellow A, B etc., Polyphenols is as chlorogenic acid, caffeic acid, catechol etc., also plant volatile ingredient as methyl cinnamate, Flos Caryophylli alkene, Flos Caryophylli alkene epoxide etc. containing more than 80, and 16 seed amino acid as lysine, fatty acid is as Palmic acid, myristic acid, lauric acid, oleic acid etc., another containing Flos Carthami polysaccharide and other multiple active components; Acrid in the mouth, warm in nature, GUIXIN, Liver Channel; Energy promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing; Cure mainly blood stasis amenorrhea, dysmenorrhea, postpartum stagnation stomachache, obstruction of qi in the chest and cardialgia, lumps in the chest and abdomen, traumatic injury, arthralgia, apoplectic hemiplegia etc.; Modern pharmacology proves that Flos Carthami has anticoagulation, antiinflammatory, antioxidation etc., has antifungal activity to multiple strains such as Candida albicans.
Radix Saposhnikoviae: be the root of Umbelliferae Radix Saposhnikoviae platymiscium Radix Saposhnikoviae; Containing chromone constituents as Radix Saposhnikoviae chromone alcohol etc., Coumarins composition is as bergapten, psoralen, phellopterin etc., polyacetylene constituents is as Panaxynol etc., polysaccharide component is as Radix Saposhnikoviae acidic polysaccharose A, C, volatile oil, as octanal etc., also contains the plurality of active ingredients such as cupreol, vanillic acid, wogonin; Radix Saposhnikoviae acrid in the mouth, sweet, slightly warm in nature, returns bladder, lung, spleen channel; Can expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion, antipruritic; Cure mainly affection of exogenous wind-cold, migraine and general headache, rheumatic arthralgia, stomachache had loose bowels, discharging fresh blood stool, tetanus, infantile convulsion, kite pruritus, skin infection from the beginning of etc.; Modern pharmacology proves that Radix Saposhnikoviae has antipyretic cooling, analgesia, calmness, convulsion, antiinflammatory, antibacterial, antitumor action etc.Bibliographical information, sposknikovan Contained Serum has the effect of conditioner body immunity function, and Radix Saposhnikoviae has certain antibacterial activity to fungus.
Radix Bupleuri: be the root of Umbelliferae Bupleunim. L Radix Bupleuri or Radix Bupeuri Scorzonerfolii.; Containing volatile oil as o-methoxyphenol, eugenol, cresols etc., saponin component is as saikoside a, b 2, b 3, c etc., flavonoid is as the plurality of active ingredients such as rutin, Quercetin; Radix Bupleuri bitter in the mouth, pungent, cold nature, returns liver, gallbladder meridian; Can induce sweat bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy; Cure mainly fever caused by exogenous pathogens, alternate attack of chill and fever, malaria, hypochondriac pain due to stagnation of liverQI mammary swelling, headache dizziness etc.; Modern pharmacology proves that Radix Bupleuri has the effects such as antiinflammatory, antitumor, antibacterial, antiviral, antipyretic, calm, analgesia, antitussive, has regulating action to liver, gastrointestinal tract, immunologic function, blood fat etc.
Radix Glycyrrhizae: be the root and rhizome of pulse family glycyrrhiza genus Radix Glycyrrhizae, smooth bark Radix Glycyrrhizae, Glycyrrhiza inflata Bat.; Containing triterpene saponin as glycyrrhizin, Glycyrrhiza uralensis Fisch. saponin A, B etc., flavone compound is as 4',7-Dihydroxyflavanone, liquirtin etc., coumarin kind compound is as glycycoumarin, glycyol etc., alkaloids is as quinolines, iloquinoline derivative etc., polysaccharide, as Radix Glycyrrhizae glucosan GBW, Angelica Polysaccharide UA, UB, UC etc., also contains the plurality of active ingredients such as Radix Glycyrrhizae benzofuran, n-tricosane; Radix Glycyrrhizae sweet in the mouth, property is put down, and returns spleen, stomach, the heart, lung meridian; Can and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription; Process with controlling weakness of the spleen and stomach, asthenia lack of appetite, stomachache loose stool, the anxious pain of extremity contraction, cardiopalmus, hysteria, consumptive lung disease cough, raw with controlling laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore, infantile carbuncle and medicine, alimentary toxicosis etc.; Modern pharmacology proves the effects such as Radix Glycyrrhizae has antimicrobial, antiinflammatory, antitussive, eliminates the phlegm, antitumor, mutation, antioxidation, has regulating action to digestive system, cardiovascular system, reproductive system and brain, renal function etc.
Be used for the treatment of a Chinese medicine composition for fungal keratitis after immunosuppressant, conventional method can be adopted to be prepared into the form of Chinese drug such as oral liquid, granule, powder, pill, tablet, capsule.The invention provides a kind of preparation method of oral liquid medicine.
Be used for the treatment of a preparation method for the Chinese medicine composition of fungal keratitis after immunosuppressant, comprise the following steps: accurately get each crude drug according to parts by weight, decoct with water rear filtration, filtrate is oral liquid medicine.
Concrete, be used for the treatment of the preparation method of the Chinese medicine composition of fungal keratitis after immunosuppressant, comprise the following steps:
(1) gram to be weight portion unit, accurately get each crude drug, except roud cardamon seed, all the other crude drug add in 1.5L water, soak 30 minutes, fried 30 minutes of fire of larding speech with literary allusions after intense fire boils, filter and remove residue, and this is the first fried liquid;
(2) add in 1L water by the medicinal residues in step (1), lard speech with literary allusions after intense fire boils fiery fried 20 minutes, add roud cardamon seed, continue decoction 25 minutes, filter and remove residue, this is the second fried liquid; Merge twice fried liquid, being the oral liquid medicine being used for the treatment of fungal keratitis after immunosuppressant, is a daily dose.
The usage of oral liquid and consumption: the medicinal liquid of every daily dose divides to be taken for 2 ~ 3 times, and within 1 hour after meal, take as good, serveing on 14 is a course for the treatment of.
Beneficial effect of the present invention:
After immunosuppressant application, typical clinical manifestation has: spiritlessness and weakness, dizziness and blurred vision, shallow complexion, tinnitus asthenia, shortness of breath and palpitation, and abdominal distention, pale tongue is dark, and thready pulse, is similar to the traditional Chinese medical science " asthenia " category.Fungal keratitis is modern medicine name of disease, and main clinical manifestation is: or itch or pain, photophobia is shed tears, the raw nebula of black eyeball, and nebula is not fallen apart for a long time, as white lipoid shape, and sharpness of border or unintelligible, air spots, micro-protuberance, the visible pseudopodium of perilesional or satellite stove.The traditional Chinese medical science " black eyeball nebula " category is belonged to according to its main clinical manifestation.The fungal keratitis pathogenesis that immunosuppressant causes belongs to deficiency in origin and excess in superficiality, and deficiency in origin is that immunosuppressant use causes, and mark is real is cornea fungal infection.Deficiency in origin belongs to spleen kidney deficiency, deficiency of both QI and YIN, and mark is real is Shi Re Bing Pian and blood stasis.The present invention just with the Chinese medicine compound that " kidney and spleen invigorating, supplementing QI and nourishing YIN, clearing away heat-damp and promoting diuresis, removing toxic substances are invigorated blood circulation " provides for therapy, determined curative effect.
Chinese medicine composition of the present invention by Radix Astragali Preparata, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Atractylodis (parched), Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Lycii, Fructus Ligustri Lucidi, Semen Armeniacae Amarum, roud cardamon seed etc. totally 23 taste Chinese herbal medicine compatibilities form: side in the Radix Astragali sweet, warm, return lung, spleen channel, for invigorating the spleen and replenishing QI key medicine, be apt to promoting pus discharge and tissue regeneration strengthening again simultaneously.Radix Codonopsis is sweet, flat, returns spleen, lung meridian, invigorating the spleen and replenishing QI, promotes the production of body fluid and nourish blood.Rhizoma Atractylodis Macrocephalae (parched): bitter, sweet, warm, returns spleen, stomach warp, air making-up and spleen enlivening, dampness diuretic.Rhizoma Atractylodis (parched) is pungent, bitter, and temperature, returns spleen, stomach, Liver Channel, drying damp and strengthening spleen, expelling wind and cold, improving eyesight.Radix Rehmanniae Preparata is sweet, tepor, returns liver, kidney channel, nourishing the blood and yin, vital essence replenishing and marrow benifiting.Rhizoma Dioscoreae is sweet, flat, returns spleen, lung, kidney channel, supplementing QI and nourishing YIN, mends strengthening spleen and lung, tonifying the kidney to consolidate the essence.Fructus Lycii is sweet, flat, returns liver, kidney, lung meridian, nourishing the liver and kidney, improving eyesight.Fructus Ligustri Lucidi is sweet, bitter, cool, returns liver, kidney channel, liver and kidney tonifying, clearing away heat to improve acuity of vision.Upper seven taste Chinese medicines are for the spleen kidney deficiency of primary disease deficiency in origin, and deficiency of both QI and YIN, gathers the merit of kidney and spleen invigorating, supplementing QI and nourishing YIN altogether.In side, pungent, bitter, the tepor of Semen Armeniacae Amarum, returns liver, large intestine channel, opens lung qi, makes damp from upper and separate; Roud cardamon seed is pungent, warm, returns lung, spleen, stomach warp, removing dampness, circulation of qi promoting, warming middle-JIAO, preventing or arresting vomiting.Semen Coicis is sweet, light, is slightly cold, and returns spleen, stomach, lung meridian, gets its promoting diuresis to eliminate damp pathogen, effect of clearing away heat and discharging pus.Three core are share, can declare, smooth in, ooze lower and tool eliminating damp-heat, declare the merit of smooth three burnt mechanisms of qi.Cortex Magnoliae Officinalis is bitter, pungent, warm, returns spleen, stomach, lung, large intestine channel, dampness circulation of qi promoting, lowering the adverse QI to relieve asthma.Folium Bambusae is sweet light, cold, enters the heart, lung, gallbladder, stomach warp, energy clearing away heat-fire, arresting lacrimation diuresis.In side, Semen Armeniacae Amarum, KOUREN, Semen Coicis, Cortex Magnoliae Officinalis and Folium Bambusae are for damp and hot pathogenesis, have the merit of clearing away heat-damp and promoting diuresis.In side, Flos Lonicerae is sweet, cold, returns lung, the heart, stomach, large intestine channel, heat-clearing and toxic substances removing, dispelling wind and heat pathogens.Flos Chrysanthemi Indici is pungent, sweet, bitter, be slightly cold, and returns lung, Liver Channel, dispelling wind and heat pathogens, liver heat removing and eyesight improving.Herba Taraxaci is sweet, bitter, cold, returns liver, stomach warp, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Flos Lonicerae, Flos Chrysanthemi Indici and Herba Taraxaci, for the evil cause of disease of primary disease fungus poison, have the merit of heat clearing away virus killing.Bitter, the acid of the Radix Paeoniae Alba in side, to be slightly cold, to enter liver, spleen channel, yin fluid astringing of enriching blood.Radix Angelicae Sinensis is sweet, pungent, warm, returns liver, the heart, spleen channel, enriches blood, invigorates blood circulation.Rhizoma Chuanxiong is pungent, warm, enters liver, gallbladder, pericardium channel, blood-activating and qi-promoting.Flos Carthami is pungent, warm, GUIXIN, Liver Channel, and blood circulation promoting and blood stasis dispelling, stimulates the menstrual flow.In side, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Chuanxiong composition SIWU TANG, be classics side's medicine that blood-supplementing blood-nourishing is invigorated blood circulation, add Flos Carthami nourshing blood and promoting blood circulation, for the pathogenesis of blood stasis of primary disease.In side, pungent, sweet, the tepor of Radix Saposhnikoviae, returns bladder, liver, spleen channel, expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic.Radix Bupleuri is bitter, pungent, be slightly cold, and returns liver, gallbladder meridian, induces sweat and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Radix Saposhnikoviae in side, Radix Bupleuri are used as guiding drug, priming up enter order.Radix Glycyrrhizae is sweet, flat, GUIXIN, lung, spleen, stomach warp, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.Through modern pharmacological research, in we, the Radix Astragali, Rhizoma Atractylodis, Fructus Ligustri Lucidi, Flos Lonicerae, Flos Chrysanthemi Indici, Herba Taraxaci, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Flos Carthami, Radix Saposhnikoviae have antifungic action.
Chinese medicine composition of the present invention is both for the card of the spleen kidney deficiency, deficiency of both QI and YIN and the damp and hot blood stasis that occur after immunosuppressant application, the side's of sending medication is with kidney and spleen invigorating, supplementing QI and nourishing YIN, clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, evil for fungal infection poison again, the medicine of reusing killing fungus carries out heat-clearing and toxic substances removing.Full policy to complicated pathogenesis, treating both the principal and secondary aspects of a disease.Medication has following characteristics: the same use of (1) strengthening vital QI to eliminate pathogenic factors, makes eliminating evil just wound; (2) spleen kidney is with mending, and the benefit benefit day after tomorrow is congenital; (3) using medicines of both cold and hot natures simultaneously, make Quan Fangwen and not dry, tremble with fear clearly and not; (4) invigorate blood circulation and do not forget to enrich blood, blood stasis dispelling is blood trouble not; (5) medication both met Chinese medical theory, had again the support of modern pharmacological research, finally made the agent that we become efficient, gentle.
The present invention adopts pure natural Chinese herbal medicine, and medicine source is abundant, medicine valency is cheap, has no side effect, and preparation method is simple, is suitable for large-scale industrial production.
Detailed description of the invention
Following embodiment is only described in further detail the present invention, does not form any limitation of the invention.
Embodiment 1
Be used for the treatment of the Chinese medicine composition of fungal keratitis after immunosuppressant in the present embodiment, be made up of the crude drug of following parts by weight: Radix Astragali Preparata 30 parts, Radix Codonopsis 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 12 parts, Rhizoma Atractylodis (parched) 9 parts, 15 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 30 parts, Fructus Lycii 12 parts, Fructus Ligustri Lucidi 12 parts, Semen Armeniacae Amarum 9 parts, roud cardamon seed 6 parts, Semen Coicis 30 parts, Herba Lophatheri 12 parts, Cortex Magnoliae Officinalis 9 parts, Flos Lonicerae 12 parts, Flos Chrysanthemi Indici 15 parts, Herba Taraxaci 15 parts, the Radix Paeoniae Alba 15 parts, Radix Angelicae Sinensis 12 parts, Rhizoma Chuanxiong 9 parts, 9 parts, Flos Carthami, Radix Saposhnikoviae 9 parts, Radix Bupleuri 9 parts, 9 parts, Radix Glycyrrhizae.
Be used for the treatment of the preparation method of the Chinese medicine composition of fungal keratitis after immunosuppressant in the present embodiment, comprise the following steps:
(1) gram to be weight portion unit, accurately get each crude drug, except roud cardamon seed, all the other crude drug add in 1.5L water, soak 30 minutes, fried 30 minutes of fire of larding speech with literary allusions after intense fire boils, filter and remove residue, and this is the first fried liquid;
(2) add in 1L water by the medicinal residues in step (1), lard speech with literary allusions after intense fire boils fiery fried 20 minutes, add roud cardamon seed, continue decoction 25 minutes, filter and remove residue, this is the second fried liquid; Merge twice fried liquid, being the oral liquid medicine being used for the treatment of fungal keratitis after immunosuppressant, is a daily dose.
The usage of oral liquid and consumption: the medicinal liquid of every daily dose divides to be taken for 2 ~ 3 times, and within 1 hour after meal, take as good, serveing on 14 is a course for the treatment of.
Embodiment 2
Be used for the treatment of the Chinese medicine composition of fungal keratitis after immunosuppressant in the present embodiment, be made up of the crude drug of following parts by weight: Radix Astragali Preparata 20 parts, Radix Codonopsis 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, Rhizoma Atractylodis (parched) 6 parts, 12 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 20 parts, Fructus Lycii 10 parts, Fructus Ligustri Lucidi 10 parts, Semen Armeniacae Amarum 6 parts, roud cardamon seed 6 parts, Semen Coicis 20 parts, Herba Lophatheri 10 parts, Cortex Magnoliae Officinalis 6 parts, Flos Lonicerae 10 parts, Flos Chrysanthemi Indici 10 parts, Herba Taraxaci 10 parts, the Radix Paeoniae Alba 12 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Chuanxiong 6 parts, 6 parts, Flos Carthami, Radix Saposhnikoviae 6 parts, Radix Bupleuri 6 parts, 6 parts, Radix Glycyrrhizae.
The preparation method of Chinese medicine composition of fungal keratitis after immunosuppressant and the usage and dosage of medicine is used for the treatment of with embodiment 1 in the present embodiment.
Embodiment 3
Be used for the treatment of the Chinese medicine composition of fungal keratitis after immunosuppressant in the present embodiment, be made up of the crude drug of following parts by weight: Radix Astragali Preparata 9 parts, Radix Codonopsis 9 parts, Rhizoma Atractylodis Macrocephalae (parched) 6 parts, Rhizoma Atractylodis (parched) 3 parts, 9 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 15 parts, Fructus Lycii 6 parts, Fructus Ligustri Lucidi 6 parts, Semen Armeniacae Amarum 6 parts, roud cardamon seed 3 parts, Semen Coicis 9 parts, Herba Lophatheri 6 parts, Cortex Magnoliae Officinalis 3 parts, Flos Lonicerae 6 parts, Flos Chrysanthemi Indici 9 parts, Herba Taraxaci 9 parts, the Radix Paeoniae Alba 6 parts, Radix Angelicae Sinensis 6 parts, Rhizoma Chuanxiong 3 parts, 3 parts, Flos Carthami, Radix Saposhnikoviae 6 parts, Radix Bupleuri 3 parts, 3 parts, Radix Glycyrrhizae.
The preparation method of Chinese medicine composition of fungal keratitis after immunosuppressant and the usage and dosage of medicine is used for the treatment of with embodiment 1 in the present embodiment.
Embodiment 4
Be used for the treatment of the Chinese medicine composition of fungal keratitis after immunosuppressant in the present embodiment, be made up of the crude drug of following parts by weight: Radix Astragali Preparata 15 parts, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 9 parts, Rhizoma Atractylodis (parched) 6 parts, 10 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 20 parts, Fructus Lycii 9 parts, Fructus Ligustri Lucidi 9 parts, Semen Armeniacae Amarum 6 parts, roud cardamon seed 6 parts, Semen Coicis 15 parts, Herba Lophatheri 9 parts, Cortex Magnoliae Officinalis 6 parts, Flos Lonicerae 9 parts, Flos Chrysanthemi Indici 12 parts, Herba Taraxaci 9 parts, the Radix Paeoniae Alba 12 parts, Radix Angelicae Sinensis 9 parts, Rhizoma Chuanxiong 6 parts, 6 parts, Flos Carthami, Radix Saposhnikoviae 6 parts, Radix Bupleuri 6 parts, 6 parts, Radix Glycyrrhizae.
The preparation method of Chinese medicine composition of fungal keratitis after immunosuppressant and the usage and dosage of medicine is used for the treatment of with embodiment 1 in the present embodiment.
Embodiment 5
Be used for the treatment of the Chinese medicine composition of fungal keratitis after immunosuppressant in the present embodiment, be made up of the crude drug of following parts by weight: Radix Astragali Preparata 12 parts, Radix Codonopsis 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 parts, Rhizoma Atractylodis (parched) 6 parts, 9 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 15 parts, Fructus Lycii 9 parts, Fructus Ligustri Lucidi 6 parts, Semen Armeniacae Amarum 6 parts, roud cardamon seed 6 parts, Semen Coicis 12 parts, Herba Lophatheri 6 parts, Cortex Magnoliae Officinalis 6 parts, Flos Lonicerae 10 parts, Flos Chrysanthemi Indici 10 parts, Herba Taraxaci 10 parts, the Radix Paeoniae Alba 12 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Chuanxiong 6 parts, 3 parts, Flos Carthami, Radix Saposhnikoviae 6 parts, Radix Bupleuri 6 parts, 6 parts, Radix Glycyrrhizae.
The preparation method of Chinese medicine composition of fungal keratitis after immunosuppressant and the usage and dosage of medicine is used for the treatment of with embodiment 1 in the present embodiment.
Clinical trial
1, diagnostic criteria
There are immunosuppressant or glucocorticoid medication history, there is fungal keratitis clinical manifestation, and through cornea scraping blade or the confocal observation of cornea live body or cornea scraping blade positive for fungi culture person.
2, state of an illness weight grade scale
Slight: corneal ulcer area≤4mm 2, ulcer scope table is shallow, does not accompany hypopyon;
Moderate: corneal ulcer diameter > 4mm 2but≤15mm 2, the ulcer degree of depth reaches 50% of corneal thickness, companion's hypopyon;
Severe: corneal ulcer diameter > 15mm 2, the ulcer degree of depth exceedes corneal thickness 75%, companion's hypopyon.
3, grouping and Therapeutic Method
Include case in and carry out hierarchical grouping according to state of an illness weight, be dispensed on Western medicine group and Chinese drug-treated group respectively.Western medicine group gives 5% natamycin eye drop eye drip, 1 time/1h; The Chinese herbs decoction of Chinese drug-treated group oral embodiment 2 every day, one day 2 times.Within 14 days, be a course for the treatment of, after 4 courses for the treatment of of medication, judge curative effect.
4, case rejects standard
A, not by regulation medication, cannot curative effect person be judged;
The infull person of b, collection of data;
C, duration of test have actute infection to affect result judgement person.
5, curative effect determinate standard
Cure: corneal irritation disappears, ulcer surface heals, and cornea fluorescence staining is negative, and hypopyon disappears, and live body confocal cornea scanning fungus disappears;
Take a turn for the better: irritation alleviates, and ulcer area reduces limitation, hypopyon reduces or disappears;
Invalid: focus is unchanged, various symptom is without improvement or increase the weight of, and ulcer increases the weight of or bores a hole.
6, interpretation of result
(1) Western medicine group compares with Chinese drug-treated group patient ordinary circumstance
The patient of Western medicine group and Chinese drug-treated group from, sex, age, immunosuppressant and glucocorticoid uses, severity Scaling aspect compares, no significant difference (P > 0.05), two groups of results have comparability.General clinical data situation is in table 1.
Table 1 Western medicine group compares with Chinese drug-treated group patient ordinary circumstance
(2) Western medicine group compares with Chinese drug-treated group therapeutic effect
Table 2 Western medicine group compares with Chinese drug-treated group therapeutic effect
Conclusion: after treating four courses for the treatment of, two groups of patient clinical symptoms and sign are all improved in varying degrees, corneal ulcer area reduces, hypopyon absorbs, and leaves over white macula in various degree or nebula.The total effective rate of its Chinese medicine and western medicine group is 76.6%, and the total effective rate of Chinese drug-treated group is 90.4%, and the total effective rate of Chinese drug-treated group comparatively Western medicine group significantly improves (P < 0.05), in table 2.
Model case
Case 1: Zhang, female, 35 years old, with the slight foreign body sensation of left eye, companion's visual deterioration was gone to a doctor for about 3 weeks.Patient's eye pain, photophobia, the irritation such as to shed tears are not obvious, and see under slit lamp: conjunctiva mixed congestion, corneal ulcer, area is about 7mm 2, perilesional corneal edema, focus are canescence lipoid shape, sharpness of border, surperficial micro-protuberance, the visible pseudopodium of perilesional.The confocal inspection of live body finds fungus.Inquiring finds, patient suffers from lupus erythematosus and taken prednisone 3 months, without cornea trauma history.The obvious Ke Xing face of patient, face color Koushi is white, and with tired, distension and fullness in the abdomen, yellow urine constipation, bitter taste halitosis, light red tongue is dark, red tongue margin, thick, yellow and greasy fur, thready and rapid pulse.Card belongs to asthenia of both the spleen and kidney, with liver and gall heated, and showing tremendous enthusiasm upper inflammation.Treat the oral liquid medicine prepared with the embodiment of the present invention 2, one day 2 times, advise further consultation after 1 week; Two foreign body sensations of eye when examining alleviate, and corneal ulcer area reduces, and live body confocal inspection fungus tails off, tired, distension and fullness in the abdomen, and bitter taste halitosis alleviates, and light red tongue is dark, tongue tip side of red, yellow and greasy fur, thready and rapid pulse.The state of an illness alleviates, and square medicine is effective, and defence is constant, advises 2 Zhou Houzai to examine.Three subjective symptomss of eye when examining obviously alleviate, and vision increases, and corneal ulcer area reduces, and focus flattens smooth, live body is confocal can not find fungus, and fungal culture is negative, and the conscious strength of patient increases, and complexion is gloss slightly, thick fur is greasy to be alleviated, and defence is constant, advises further consultation after 3 weeks.During the four diagnostic methods, eye's subjective symptoms disappears, vision restoration, and corneal ulcer disappears, and focus absorbs, and fluorescent staining is negative, and live body is confocal can not find fungus, and fungal culture is negative, patient's complexion slightly gloss, and thick fur is greasy to be alleviated, and defence is constant, continuous with a course for the treatment of.After follow up a case by regular visits to 1 year, do not recur.
Case 2: Jiao, man, 20 years old, goes to a doctor with cornea of right eye ulcer for about 3 weeks.Patient's right eye foreign body sensation, pain, the irritation such as to shed tears are not obvious, and see under slit lamp: conjunctiva mixed congestion, corneal ulcer, area is about 8mm 2, perilesional corneal edema, focus are canescence lipoid shape, surperficial micro-protuberance, the visible pseudopodium of perilesional.Cornea scraping blade finds fungus, and cornea is cultivated as candida albicans infection.Inquiring finds, patient suffers from nephrotic syndrome 3 years, Long-term Hormone, without cornea trauma history.The obvious Ke Xing face of patient, face color Koushi is white, and with tired, distension and fullness in the abdomen, yellow urine, bitter taste halitosis, light red tongue is dark, tongue tip side of red, thick, yellow and greasy fur, thready and rapid pulse.Card belongs to asthenia of both the spleen and kidney, with liver and gall intenseness of heat.Treat the oral liquid medicine prepared with the embodiment of the present invention 1, one day 2 times, advise further consultation after 2 weeks; Two foreign body sensations of eye when examining alleviate, and corneal ulcer area reduces, and the confocal inspection of live body does not find fungus, tired, distension and fullness in the abdomen, and bitter taste halitosis alleviates, and light red tongue is dark, red tip of the tongue, yellow and greasy fur, thready and rapid pulse.The state of an illness alleviates, and square medicine is effective, and defence is constant, advises 2 Zhou Houzai to examine.Three subjective symptomss of eye when examining obviously alleviate, and corneal ulcer area continues to reduce, and ulcer stove is smooth, and live body is confocal does not find fungus, and fungal culture is negative, and patient mental takes a turn for the better, and thick fur is greasy to be alleviated, and defence is constant, advise further consultation afterwards in 3 weeks.During the four diagnostic methods, eye's subjective symptoms disappears, vision restoration, and corneal ulcer disappears, and focus absorbs, and fluorescent staining is negative.Defence is constant, continuous with consolidating a course for the treatment of.After follow up a case by regular visits to 2 years, do not recur.

Claims (3)

1. one kind is used for the treatment of the Chinese medicine composition of fungal keratitis after immunosuppressant, it is characterized in that: be made up of the raw material of Chinese medicine of following parts by weight: Radix Astragali Preparata 9 ~ 30 parts, Radix Codonopsis 9 ~ 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 6 ~ 12 parts, Rhizoma Atractylodis (parched) 3 ~ 9 parts, 9 ~ 15 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 15 ~ 30 parts, Fructus Lycii 6 ~ 12 parts, Fructus Ligustri Lucidi 6 ~ 12 parts, Semen Armeniacae Amarum 6 ~ 9 parts, roud cardamon seed 3 ~ 6 parts, Semen Coicis 9 ~ 30 parts, Herba Lophatheri 6 ~ 12 parts, Cortex Magnoliae Officinalis 3 ~ 9 parts, Flos Lonicerae 6 ~ 12 parts, Flos Chrysanthemi Indici 9 ~ 15 parts, Herba Taraxaci 9 ~ 15 parts, the Radix Paeoniae Alba 6 ~ 15 parts, Radix Angelicae Sinensis 6 ~ 12 parts, Rhizoma Chuanxiong 3 ~ 9 parts, 3 ~ 9 parts, Flos Carthami, Radix Saposhnikoviae 6 ~ 9 parts, Radix Bupleuri 3 ~ 9 parts, 3 ~ 9 parts, Radix Glycyrrhizae.
2. one kind is used for the treatment of the preparation method of the Chinese medicine composition of fungal keratitis after immunosuppressant as claimed in claim 1, it is characterized in that: comprise the following steps: accurately get each crude drug according to parts by weight, decoct with water rear filtration, filtrate is oral liquid medicine.
3. the preparation method being used for the treatment of the Chinese medicine composition of fungal keratitis after immunosuppressant according to claim 2, is characterized in that: comprise the following steps:
(1) gram to be weight portion unit, accurately get each crude drug, except roud cardamon seed, all the other crude drug add in 1.5L water, soak 30 minutes, fried 30 minutes of fire of larding speech with literary allusions after intense fire boils, filter and remove residue, and this is the first fried liquid;
(2) add in 1L water by the medicinal residues in step (1), lard speech with literary allusions after intense fire boils fiery fried 20 minutes, add roud cardamon seed, continue decoction 25 minutes, filter and remove residue, this is the second fried liquid; Merge twice fried liquid, obtain oral liquid medicine.
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