CN104324310B - It is a kind of to be used to treat Chinese medicine composition of fungal keratitis and preparation method thereof after immunosupress - Google Patents

Abstract

It is used to treat Chinese medicine composition of fungal keratitis and preparation method thereof after immunosupress the invention discloses a kind of, belongs to technical field of Chinese medicine.The Chinese medicine composition by astragalus root, Radix Codonopsis, rhizoma atractylodis macrocephalae, fry rhizoma atractylodis, cultivated land etc. totally 23 taste Chinese herbal medicine composition of prescription, both the assertive evidence of the spleen kidney deficiency, deficiency of both qi and yin and the damp and hot hemostasis that occur after being applied for immunodepressant, with kidney and spleen invigorating, supplementing qi and nourishing yin, clearing heat and promoting diuresis, promoting blood circulation, the standard card of the malicious heresy of infection fungi is directed to again, and the medicine progress for reusing killing fungi is clearing heat and detoxicating.Full policy is treated both principal and secondary aspect of disease, medication has following characteristics to the complicated interpretation of the cause, onset and process of an illness：(1) strengthening vital QI to eliminate pathogenic factors makes eliminating evil not hinder just with using；(2) spleen kidney is with mending, and the benefit benefit day after tomorrow is congenital；(3) using medicines of both cold and hot natures simultaneously, makes full side warm but not dry, clear without cold；(4) promoting blood circulation is not forgotten to enrich blood, dissolving stasis not blood trouble；(5) medication both meets traditional Chinese medical theory, the support for having modern pharmacological research again, finally makes we into efficient, gentle agent.

Description

A kind of Chinese medicine composition and its system for being used to treat fungal keratitis after immunosupress Preparation Method

Technical field

The present invention relates to a kind of Chinese medicine composition for being used to treat fungal keratitis after immunosupress, and the Chinese medicine group The preparation method of compound, belongs to technical field of Chinese medicine.

Background technology

Cornea fungal infection is a kind of clinically common blinding, infectious eye disease, is to infect cornea by pathomycete Cause, be China's suppurative keratitis and the main cause of corneal transplantation, be the first cause of disease of corneal blindness.The disease is clinical ophthalmology Doctor often faces, and the state of an illness is dangerous, but treats very intractable disease.Natively compare mainly due to the treatment for fungi Difficulty, the in addition special construction of cornea and ocular barrier so that antifungal drug is difficult to penetrate into inside cornea, therefore, Fungal keratitis is a kind of extremely difficult keratitis of clinical treatment.A big chunk patient is uncontrollable because of the state of an illness, most Corneal transplantation is needed eventually, due in great shortage in China's corneal donor, so a part of patient is to prevent disease progression, it has to carry out Eyeball excise, ultimately results in blindness.Therefore, fungal keratitis has turned into China's ophthalmic industry great section's knowledge urgently to be resolved hurrily Topic.

The cause of disease of fungal keratitis is a lot, there is vegetalitas wound, contact lens to wear, corticosteroid hormone and Immunodepressant is caused using rear immunosuppressive condition.Vegetalitas wound, contact lens wear caused fungal keratitis It is the fungal infection under normal immunological state, is treated using antifungal drug.And corticosteroid hormone and immune suppression Preparation uses cornea fungal infection caused by rear immunosuppressive condition, and immune status is extremely main cause, though clinical treatment is non- It is often intractable, but immune state recovers normal, and Opportunistic Pathogen Infection is removed naturally.Chinese medicine compound prescription is adjusted and immune tune in whole body function It is very advantageous in terms of section.But the Chinese medicine compound prescription for fungal keratitis caused by immunosupress is not still found at present Document, report or disclosed patent.

The content of the invention

It is an object of the invention to provide a kind of Chinese medicine composition for being used to treat fungal keratitis after immunosupress.

Meanwhile, the present invention also provides a kind of preparation for being used to treat the Chinese medicine composition of fungal keratitis after immunosupress Method.

In order to realize the above object the technical solution adopted in the present invention is：

A kind of Chinese medicine composition for being used to treat fungal keratitis after immunosupress, it is former by the Chinese medicine of following parts by weight Material composition：9~30 parts of astragalus root, 9~30 parts of Radix Codonopsis, 6~12 parts of rhizoma atractylodis macrocephalae, 3~9 parts of rhizoma atractylodis of stir-fry, 9~15 parts of cultivated land, Chinese yam 15~30 parts, 6~12 parts of the fruit of Chinese wolfberry, 6~12 parts of the fruit of glossy privet, 6~9 parts of semen armeniacae amarae, 3~6 parts of roud cardamon seed, 9~30 parts of coix seed, 6~12 parts of lophatherum gracile, 3~9 parts of the bark of official magnolia, 6~12 parts of honeysuckle, 9~15 parts of chrysanthemum indicum, 9~15 parts of dandelion, the root of herbaceous peony 6~15 Part, 6~12 parts of Radix Angelicae Sinensis, 3~9 parts of Ligusticum wallichii, 3~9 parts of safflower, windproof 6~9 parts, 3~9 parts of radix bupleuri, 3~9 parts of radix glycyrrhizae.

Each bulk drug effect is summarized as follows：

The Radix Astragali：For pulse family Astragalus astragalus mongolicus and the root of Astragalus membranacus；It is different containing saponin component such as astragalin Flavone component such as calycosin, fatty acid such as palmitic acid and linoleic acid, polysaccharide such as astragalus polyose, heteroglycan etc., and Nearly 20 various trace elements；The Radix Astragali is sweet, warm-natured, return lung, the spleen channel；Can benefiting qi and raising yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, eliminating toxic Myogenic；Cure mainly the disease of all Qi and blood deficiencies, such as splenasthenic diarrhea, cough due to deficiency of the lung, prolapse of the anus, metroptosis, spontaneous perspiration, night sweat, oedema, blood Numbness, to ulcer is difficult to burst or burst for a long time and does not holds back person's excellent.Modern pharmacology research to the Radix Astragali shows：1) astragalus polyose is the Radix Astragali In most important natural constituent, astragalus polyose can improve immune function of human body, and enhancing cell physiological metabolism improves macrophage thin Cytoactive, it can strengthen immune organ weight, promote T and bone-marrow-derived lymphocyte conversion ratio.Having also been reported astragalus polyose stimulates mouse B to drench Bar cell and macrophage.Astragalus polyose may additionally facilitate thick liquid cell hyperplasia and antibody synthesis, strengthen humoral immunity, in vivo and body It is outer to be obviously promoted NK cells in mice activity, stimulate NK cells propagation, it is often more important that astragalus polyose can cooperate with leucocyte to be situated between Element 2 is acted on, and is made NK cytoactives and is stimulated the effect of NK cells propagation to significantly improve, equal to the panimmunity Defect such as AIDS There is good preventive and therapeutic effect.2) Radix Astragali also has antifungic action.Therefore, no matter from basic theory of tcm, or modern study, The Radix Astragali not only adjusts immune, also antifungic action, is the fit closely Chinese medicine of the immune rear fungal keratitis for the treatment of.

Astragalus root：Preparing astragalus membranaceus, the Radix Astragali cuts inclined tab, and honey is put in pot, slow fire be cooked (the sweet droplet of fusing enters in cold water, Soft pearl ball can be formed, degree of raw and cooked differentiates according to color), a little boiling water dilution honey stickiness is added, astragalus mongholicus tablet stirring is put into equal It is even, fry to honey juice and penetrate the piece heart, moisture fried dry is degree.Preparing astragalus membranaceus adds the benefiting action of the Radix Astragali, and longer than tonifying Qi is given birth to Blood.

Radix Codonopsis：For campanulaceae of the genus codonopsis Radix Codonopsis, codonopsis pilosula var. modesta, radix codonpsis tangshen, pipe flower Radix Codonopsis, C. subglobosa, gray wool party The root of ginseng；Contain carbohydrate such as fructose, synanthrin, polysaccharide and 4 kinds of heteroglycan CP₁、CP₂、CP₃、CP₄, glycoside such as syringin, n-hexyl- β-glucopyranoside, ethyl-α-D-fructofuranoside, tangshenoside, alkaloid and nitrogen containing component such as choline, loline etc., Also containing various active compositions such as syringaldehyde, vanillic acid, pyromucic acid, atractyloides I, II；Radix Codonopsis is sweet, mild-natured, returns spleen, Lung channel；Can strengthening the spleen and tonifying the lung, nourishing generate fluid；Cure mainly weakness of the spleen and the stomach, anorexia and loose stool, limbs fatigue, the deficiency syndrome of the lung breath with cough, shortness of breath spontaneous perspiration, gas Blood two loses all cards；Modern pharmacology prove Radix Codonopsis have enhancing physical stress ability, enhancing body's immunity, anti-aging, Antiulcer, antitumor action etc..There is document report Radix Codonopsis to significantly improve the phagocytic index of Turnover of Mouse Peritoneal Macrophages, with exempting from Epidemic disease humidification.

The bighead atractylodes rhizome：For the rhizome of the composite family rhizoma atractylodis platymiscium bighead atractylodes rhizome；Contain volatile oil such as atractylone, α and β-Humuleno, α-turmeric Alkene, palmitic acid, hinesol etc., sesquiterpene lactone compound such as atractyloide-I, II, III, IV etc., many alkynol compounds, also Containing Scopoletin, with immunocompetent mannosan AM-3, and aspartic acid, serine etc. more than ten plants amino acid；In vain Art bitter, sweet, warm-natured, returns spleen, stomach；Can strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, antiabortive；Cure mainly weak, the food of deficiency-weakness of spleen-QI Few abdominal distension, diarrhea, constipation, the difficult urination of fluid retention stagnating in the interior, oedema, phlegmatic vertigo, cold-dampness numbness, bodily pain, spontaneous perspiration due to deficiency of vital energy etc.；It is modern Pharmacology proves that there is the bighead atractylodes rhizome anti-oxidant and anti-aging, antitumor, hypoglycemic, diuresis and anti-ascites, liver protection, cholagogic etc. to make With, moreover it is possible to promote digestive system, immune system, cardiac muscle and cardiovascular system.There is document report, the bighead atractylodes rhizome is by activating T, B lymph Cell function and its cell quantity of propagation, so as to strengthen humoral immunity of organism and cellular immune function.

Rhizoma atractylodis macrocephalae：Honey wheat bran is sprinkled into hot pot, bighead atractylodes rhizome piece is added when smoldering, is fried to coke yellow, effusion burnt odor gas, Take out, weed out honey wheat bran.Per 100kg bighead atractylodes rhizome pieces, honey wheat bran 10kg is used.The rhizoma atractylodis macrocephalae shape such as bighead atractylodes rhizome, surface yellowish-brown is accidental Focal spot, somewhat burnt odor gas, mildly bitter flavor.Rhizoma atractylodis macrocephalae can relax dry property, in entering by means of bran, can strengthen invigorating the spleen, detumescence effect.

Rhizoma atractylodis：For composite family rhizoma atractylodis platymiscium Atractylis lancea, Atractylis chinensis, atractylodes japonica rhizome；Contain volatile oil such as β-olive Alkene, chamigrene, cloves alkene, elemene etc., the various active composition such as hemiterpene glycoside, ene-alkyne class, also containing cobalt, chromium, copper, manganese, The inorganic elements such as molybdenum；Pungent, hardship, warm-natured, returns spleen, stomach, Liver Channel；Can drying damp and strengthening spleen, wind-damp dispelling, improving eyesight；Cure mainly the spleen and stomach being stranded by dampness, it is tired Idle thermophilic sleeping, feeling of stuffiness in chest abdominal distension, poor appetite, vomiting and diarrhea, phlegm and retained fluid, wet wet swollen, exterior syndrome folder, head body weight pain, the wet victory of bi Zheng, podomere acid Pain is weighed；Modern pharmacology proves that rhizoma atractylodis have anti anoxia, diuresis, anti-arrhythmia, antibacterial, antivirus action etc..There is text Offer report：The grey stilbene being made up of rhizoma atractylodis, the Radix Astragali is dispersed in and can significantly increase humoral immunity, and serum antibody titer is greatly improved, Antibody existence time extends, while T lymphocyte transformation rates are also improved to some extent.In addition, rhizoma atractylodis have antimycotic work With rhizoma atractylodis leachate can cause fungal cell wall and cell interior structure to be destroyed.

Fry rhizoma atractylodis：Also known as bran fries rhizoma atractylodis, concocting method：Net rhizoma atractylodis piece is taken, is put in pot, fries slightly yellow to surface with slow fire, Taking-up is cooled, shape such as rhizoma atractylodis piece.This product shape such as rhizoma atractylodis piece, surface buff, dissipating has most sepia grease chambers.There is burnt odor gas.Fry Rhizoma atractylodis property of medicine milder, strengthens the invigorating the spleen to dry effect of rhizoma atractylodis.

Cultivated land (prepared rhizome of rehmannia)：For radix rehmanniae recen Preparation process product (radix rehmanniae recen is the root tuber of Scrophulariaceae glutinous rehmannia platymiscium glutinous rehmannia, Yellow rice wine is admixed in radix rehmanniae recen, is steamed to well-done in black, cultivated land is made in section).Cultivated land is sweet, slightly warm in nature, returns liver and kidney channel, energy Enrich blood yin-nourishing, life essence-filling, marrow-benefitting.It is mainly used in the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, the deficiency of blood is withered Huang, palpitation and severe palpitation, irregular menstruation, metrostaxis, dizziness, tinnitus, poliosis.Cultivated land contains a small amount of iridoid constituents, Separated to obtain motherwort glucoside, Aucubin, Rehmannioside A, B, C, D etc., composition containing monoterpene, such as Jiao rehmanin A, B, C, burnt again Glutinous rehmannia lactone etc., also (its composition is compared with dried rehamnnia root, without lysine, and content is accordingly reduced) containing amino acid, and sugar Class (wherein the content of monose is more than twice more than fresh rehmannia root).Modern pharmacological research shows that redemption behavior can improve mouse macrophage Cytophagic index, prepared rhizome of rehmannia Thick many candies can strengthen the expression of T lymphocyte Th1 and Th2 cell factors, exempt from mouse is improved The effect of epidemic disease function.

Chinese yam：For the stem tuber of Dioscoreaceae yam Chinese yam；Stem tuber contains diosgenin, dopamine, hydrochloric acid Chinese yam Alkali, only allantoin, wooden fork element II, also containing the amino acid such as cystine, γ-aminobutyric acid, and Chinese yam polysaccharide, barium, beryllium, cerium, cobalt Etc. various trace elements etc., rhizome contains sterols such as cholesterine, ergosterol, campesterol, stigmasterol, cupreol etc., Contain phytic acid, a of mannocarolose I, I b and I c in mucus；Chinese yam is sweet, mild-natured, returns spleen, lung, kidney channel；Can tonifying spleen, support lung, reinforce the kidney, Strengthening the essence；Cure mainly splenasthenic diarrhea, deficiency of food edema, deficiency syndrome of the lung cough and asthma, quench one's thirst, kidney deficiency frequent micturition etc.；Modern pharmacology proves that Chinese yam has drop Blood glucose, lipid-loweringing, anti-oxidant etc. are acted on, moreover it is possible to promote digestive system and immunologic function.Document report, Chinese yam polysaccharide has immune tune Section activity, can promote the phagocytic function of reticuloendothelial system, strengthen Execution, and activating phagocytic cells induce immune factor Expression, enhancing macrophage, the function of the immune system such as lymphocyte.

The fruit of Chinese wolfberry：For the fruit that the fruit of Chinese wolfberry is Solanaceae Lycium lycium barbarum；Contain Allylamines, polysaccharide, brain glycosides The yellow matter of fat, ursolic acid, alkaloid, p-Coumaric Acid, daucosterol, carrotene, atropine, hyoscyamine, maize, wintercherry fruit The various active composition such as red pigment, kryptoxanthin, vitamin C；It is sweet, mild-natured, Return liver, kidney, lung channel；Can nourishing the liver, nourshing kidney, moistening lung；It is main Caused by liver and kidney deficiency is controlled, is had a dizzy spell, visually unclear, soreness and weakness of waist and knees, cough due to consumptive disease etc.；Modern pharmacology proves that the fruit of Chinese wolfberry has and delayed The effect such as aging, anti-fatty liver, regulation blood fat and blood glucose, promotion hematopoiesis function, moreover it is possible to adjust body's immunity, effectively suppress Tumour growth and cell mutation etc..Experiment prove, the fruit of Chinese wolfberry by activating T, bone-marrow-derived lymphocyte function and breeding its cell quantity, IgA, IgG content and increase antibody-producting cell number and antibody titer are improved, so as to strengthen humoral immunity of organism and cellular immunity Function.

The fruit of glossy privet：For the fruit of Oleaceae glossy privet platymiscium glossy privet；Contain triterpenes such as oleanolic acid, acetyl olive Acid, ursolic acid, acetyl ursolic acid, phenolic glycoside class such as p-hydroxyphenylethanol, Syring vulgaris phenolic glycoside etc., the iridoid glycosides such as fruit of glossy privet Glycosides, oleuropein, different nuzhenide etc., also containing flavonoids such as racemic eriodictyol, Quercetin etc., and aliphatic acid such as palm Acid, oleic acid etc., phospholipid such as lysophosphatidyl choline, phosphatidyl-ethanolamine etc., the various active such as volatile oil such as thioacetone into Point；Sweet, hardship, it is cool in nature, return liver and kidney channel, can tonify the liver and kidney, clearind deficient heat, improving eyesight；Cure mainly Light-headedness, soreness and weakness of waist and knees, tinnitus, Poliosis, osteopyrexia and fever etc.；Modern pharmacology proves that the fruit of glossy privet has anti-inflammatory, hypoglycemic, liver protection, antimutagenesis etc..Text Report is offered, the fruit of glossy privet has humidification to Nonspecific immunity, promote the propagation of lymphocyte, strengthen gulping down for macrophage Function is bitten, and has synergy with interleukin 2, the specific cellular immunity of normal mouse is had no significant effect, to ring phosphorus The rise of micronuclei in mice cell number can substantially suppress caused by acid amides and urethane, so that the damage to cell chromosome is played Certain protective role.The fruit of glossy privet still has the effect of anti-deep fungal.

Semen armeniacae amarae：For rose family apricot platymiscium apricot, wild apricot, ansu apricot, prunus mandshuricaKoehne seed；Contain bitter taste cyanogen glycosides, phenolic ester class Such as amarogentin, prunasin, fatty oils such as linoleic acid, oleic acid, palmitic acid etc., phenolic acid class such as chlorogenic acid, neochlorogenic acid etc., Protein component such as KR-A, KR-B etc., and for example benzaldehyde, linalool etc. are a variety of has for the volatile ingredient relevant with almond flavor Imitate composition；Almond bitter, slightly warm in nature, return lung, large intestine channel；Can lowering the adverse-rising QI to resolve phlegm, it is relieving cough and asthma, relax bowel；Cure mainly exogenous cough Breathe heavily the diseases such as full, dry constipation of intestines；Modern pharmacology proves that almond has the effects such as relieving cough and asthma, antitumor, anti-inflammatory, analgesia, offsets Change system has adjustment effect.

Roud cardamon seed (White Chloe, Amomum cardamomum)：For the ripening fruits of Zingiber cardamom platymiscium Amomum cardamomum and melon Amomum cardamomum；Seed Containing volatile oil, wherein component content highest is 1, 8-Cineole 66.87%, and of a relatively high has nopinene 10.93%, australene Alkene 3.71%, cloves alkene 3.01%, borneol acetic acid esters 2.04%, alpha-terpineol 2.03%, linalool 1.39% additionally contains 4- terpinenols, aromadendrene, γ-patchoulene, α-elemene, γ-cubebene, aquation sabinene, nerolidol, sweet tea do not have Medicine alkene, amphene and Eucarvone etc.；It is pungent, warm-natured, return lung, spleen, stomach；Can dampness elimination promoting the circulation of qi, warming middle energizer to arrest vomiting, appetite-stimulating indigestion-relieving；Cure mainly Retention of damp leading to blockage of QI, incoordination between the spleen and the stomach, abdominal fullness and distention, do not feel like eating, damp-warm syndrome from the beginning of, not hungry, gastrofrigid vomiting uncomfortable in chest, dyspepsia etc.；It is existing Prove that roud cardamon seed has treating tuberculosis effect for pharmacology, the activity etc. of alcohol dehydrogenase can be influenceed.

Coix seed (adlay)：For the benevolence of grass family Job's tears platymiscium Job's tears；Contain coixenolide such as triacylglycerol, two acyls Glycerine, monoacylglycerol, sterol ester, free fatty etc., wherein free fatty include linoleic acid, palmitic acid, stearic acid, cis- 8- octadecenic acids etc., also containing glucose, acidic polysaccharose C_A-1、C_A-2And Job's tears Polysaccharide A-C, volatile oil such as hexanal, caproic acid, pungent The various active composition such as acid, ethyl palmitate, methyl linoleate, vanillic aldehyde and ethyl linoleate；Sweet, light, cold nature is returned Spleen, stomach, lung channel；Can dampness removing invigorating the spleen, relaxing muscles and tendons eliminating impediment, clearing away heat and eliminating pus；Cure mainly oedema, tinea pedis, dribbling urination, damp-warm diseases, diarrhea, band Under, arthralgia pain due to rheumatism, muscle arteries and veins contraction, lung carbuncle, acute appendicitis etc.；Modern pharmacology proves that there is coix seed antitumor, suppression skeletal muscle to receive The effect such as contracting, analgesia, antipyretic, anti-inflammatory, hypoglycemic, enhancing be immune.The coix seed oil extracted from coix seed has antitumor, increasing The effects such as strong immunity and improvement cachexia.

Lophatherum gracile (leaf of bamboo)：For the leaf of grass family mao bamboon platymiscium henon bamboo etc.；Contain alkaloid, amino acid, organic acid, phenol Class compound and tannin, saponin(e, reduced sugar, protein, polysaccharide and glycoside, anthraquinone, cumarin and terpene lactone compound, steroid Body, also containing 18 kinds of elements such as aluminium, barium, zirconium, titanium, lead, tin, gallium, strontium, iron, zinc, magnesium, calcium, manganese, nickel, copper, silver and boron and silicon；Taste It is sweet, light, cold in nature, the thoughts of returning home, lung, stomach；Can clearing heat and relieving fidgetness, promote the production of body fluid, diuresis；Cure mainly pyreticosis polydipsia, pediatric epilepsy scared, cough inverse hematemesis, Scanty drak urine, aphthous stomatitis tongue boil；Modern pharmacology proves that the leaf of bamboo has antitumor, regulation blood fat, antioxidation etc..

The bark of official magnolia：For the bark of the Magnoliaceae anil bark of official magnolia and the Mount Lushan bark of official magnolia, root skin and branch skin；Containing lignanoids such as The new phenol of magnolol, the bark of official magnolia, the bark of official magnolia aldehyde B, C etc., for example peppery menthyl magnolol of monoterpene lignanoids, double peppery menthyl magnolols, thickness Plain triphenol etc., double lignanoids such as bark of official magnolia lignan F, G, H and I, alkaloids such as magnocurarine, salicifoline, more than 30 Plant volatile oil such as sagittol, to P-cymene etc., also containing the various active composition such as sinapyladehyde, syringaresinol；Bark of official magnolia taste It is bitter, pungent, it is warm-natured, return stomach, large intestine channel；Stagnant, eliminating dampness, relieving asthma are led in energy promoting the circulation of qi；Cure mainly in stagnation of QI due to dyspepsia, abdominal distention constipation, dampness Jiao, abdominal swelling and diarrhea, phlegm stops up the circulation of vital energy in the wrong direction, chest full of cough etc.；Modern pharmacology proves that the bark of official magnolia has antiulcer, disease-resistant rovitamin, resisted The effects such as scorching analgesia, antitumor, anti-freezing.

Honeysuckle：For Caprifoliaceae woodbine honeysuckle, Lonicera confusa, wild rice gland honeysuckle, fulvoushair honeysuckle flower bud；Contain Phenolic acid class such as chlorogenic acid, isochlorogenic acid, sterols such as cupreol, volatile oil such as linalool, ethyl palmitate, leukotrienes second Ester etc., the flavonoids such as plurality of active ingredients such as galuteolin, lonicerin, Hyperoside；Honeysuckle is sweet, cold in nature；Return lung, stomach Through；Can be clearing heat and detoxicating；Cure mainly affection of exogenous wind-heat or warm disease heating, heatstroke, toxic-heat and blood stasis, carbuncle swells furunculosis, larynx numbness, multi-infection disease Disease etc.；Modern pharmacology proves that honeysuckle has the effect such as resisting pathogenic microbes, antitoxin, anti-inflammatory, reducing blood lipid.In addition, honeysuckle Polysaccharide has obvious immunological enhancement, and drug effect is related to dosage.Honegsukle flower P.E has antimycotic (candida albicans Bacterium, Candida tropicalis, Candida glabrata) activity.

Chrysanthemum indicum：For the flower of composite family Dendranthema mother chrysanthemum；Containing yejuhua lactone, chrysanthemol, chrysanthetriol, chrysanthemum indicum The sub- chrysanthemum element of ketone, chrysanthenone, cis- helicene alcohol ether, trans- helicene alcohol ether, Radix Angelicae Sinensis acyl ambrosin B, Radix Angelicae Sinensis acyl, Scotland artemisin A, thorn Sophorine, cyanidenon, chrysanthemaxanthin, daucosterol, ambrosin A, palmitic acid, ursolic acid, linoleic acid etc., also containing linarin；Bitter, It is pungent, cool in nature, return lung, Liver Channel；Can clearing heat and detoxicating, dispelling wind soothing the liver；Cure mainly furunculosis, ulcer, erysipelas, eczema, dermatitis, anemopyretic cold, Abscess of throat, headache, dizziness etc.；Modern pharmacology prove chrysanthemum indicum have antibacterial, it is antitumor, anti-oxidant, removing toxic substances, decompression and Strengthen immunity of organism effect etc..Document report, chrysanthemum indicum Polysaccharides On Cyclophosphamide induced mice immunologic hypofunction has protection Effect.In addition, chrysanthemum indicum also has Antifungal action.

Dandelion：For composite family Dandelion plant dandelion, alkali ground dandelion, Herba Taraxaci ohwiani, different luxuriant dandelion, Asia Dandelion, Taraxacum erythropodium Kifag etc. belong to the herb of various plants together；Contain taraxasterol, choline, synanthrin, pectin, apiolin, rue Fragrant glycosides etc., also containing the volatile oil such as various active composition such as n-hexyl alcohol, camphor, n-octyl alcohol；Bitter, sweet, cold in nature, Return liver, stomach； Can clearing heat and detoxicating, carbuncle that disappears dissipating bind；Cure mainly acute mastitis, lung carbuncle, acute appendicitis, mumps, scrofula, malignant boil carbuncle toxin, red eye, swell pain, cold, fever, Cough, abscess of throat, gastritis, dysentery, hepatitis, cholecystitis, urinary tract infections, snake bite and insect sting, burn and scald etc.；Modern pharmacology is proved Dandelion has resisting pathogenic microbes, antiendotoxin, antitumor, anti-gastric-ulcer, cholagogic, liver protection and adjusts the effect such as immune.It is yellow The Chinese medicine compound prescription of the compositions such as stilbene, dandelion has activation to immunocyte, can promote the conversion ratio of T lymphocytes.In addition, Pu Public English still has inhibitory action to fungi.

The root of herbaceous peony：For Paeoniaceae Paeonia plant peony (cultivation product) and the root of Peony；Containing iridoid glycosides such as Paeoniflorin, oxypaeoniflorin, benzoylpaeoniflorin, albiflorin etc., sterols such as cupreol, daucosterol, tannin such as 1,2,3, The galloyl glucoses of 6- tetra-, gallic acid, cianidanol etc., also containing volatile oil such as benzoic acid, paeonol and its His alcohols, phenols component isoreactivity composition；Bitter, acid, cold nature, Return liver, the spleen channel；Can blood-nourishing and battalion, relieving spasm to stop pain, hold back high and level tone Liver；Cure mainly deficiency of blood fever and chills, epigastric pain, hypochondriac pain, limb spasm pain, dysmenorrhoea, irregular menstruation, uterine bleeding, spontaneous perspiration, night sweat, diarrhea Diarrhea, dizziness of having a headache etc.；Modern pharmacology prove the root of herbaceous peony there is anti-inflammatory, it is analgesia, resisting pathogenic microbes, anti-mutagenesis, antitumor, resistance to Anoxia functions etc..Document report, TGP has immunological enhancement, is also resistant to oral Candida, with anti-true Bacterium potential applicability in clinical practice.

Radix Angelicae Sinensis：For the root of Umbelliferae archangel Radix Angelicae Sinensis；Containing a variety of volatile oil and organic acid, also containing kind more than 20 Inorganic elements and polysaccharide constituents；Sweet, pungent, hardship, warm-natured, Return liver, the heart, the spleen channel；Energy replenishing and activating blood, menstruction regulating and pain relieving moisturizes cunning Intestines；The all cards of the deficiency of blood are cured mainly, irregular menstruation, Amenorrhea, dysmenorrhoea , Disorder lumps in the abdomen knot gathers, uterine bleeding, asthenia cold abdominalgia, Impotence numbness, numbness, intestinal dryness Just it is difficult, weight, ulcer sores, injury from falling down etc. after dysentery characterized by blood in the stool；Modern pharmacology proves that Radix Angelicae Sinensis can influence blood and hemopoietic system, has Reducing blood lipid, anti arteriosclerosis, radioresistance, antitumor, anti-inflammatory and antalgic and antibody Monoclonal etc. are acted on.Document report, Radix Angelicae Sinensis polysaccharide energy pole Significantly or significantly improve Turnover of Mouse Peritoneal Macrophages and NK cytoactives, make mice spleen lymphocytes proliferation, to chemical factor such as The immunosuppressive condition that immunodepressant and antineoplastic trigger has obvious restitution.

Ligusticum wallichii：For the rhizome of Umbelliferae Jehol Ligusticum Rhizome platymiscium Ligusticum wallichii；Containing ligustrazine, loline or perlolyrine etc., also contain There are double phthalide-types, such as foreign Ligusticum wallichii quinone of phenolic acid class, 4-HBA, vanillic acid, caffeic acid, protocatechuic acid, and volatile oil The class such as various active composition such as Ligustilide, 3- butylidenephthalides, sabinene；It is pungent, warm-natured, Return liver, courage, pericardium channel；Can be living Blood and dissolving stasis, promote breath and open depression, wind-expelling pain-stopping；Cure mainly irregular menstruation, closed dysmenorrhea, postpartum stasis of blood, Disorder lumps in the abdomen lump, chest side of body pain Bitterly, dizziness of having a headache, wind-cold-dampness arthralgia, traumatic injury, ulcer sores etc.；Modern pharmacology proves Ligusticum wallichii to cardio-cerebrovascular, blood Liquid system, immune system etc. have protection facilitation, can antithrombotic, improvement hemorheologic parameters.In recent years, ligustrazine is in machine Body immunological regulation and the effect of anti-tumor aspect are taken seriously, and numerous studies have shown that ligustrazines can strengthen body's immunity, It is nerve immunity, hematological system, autoimmune disease, antitumor and to being respectively provided with immunoregulation effect in terms of inflammatory mediator, To having preferable facilitation in terms of Cellular Immunity, humoral immunity and nospecific immunity.In addition, Ligusticum wallichii also has Anti- deep fungal effect.

Safflower：For the flower of composite family safflower platymiscium safflower；Contain flavone compound such as carthamic acid, preceding carthamic acid, safflower Safflor yellow A, B etc., Polyphenols such as chlorogenic acid, caffeic acid, catechol etc. also plant volatile ingredient such as cinnamic acid first containing more than 80 Ester, cloves alkene, cloves alkene epoxides etc., and 16 kinds of amino acid such as lysines, fatty acid for example palmitic acid, myristic acid, Laurate, oleic acid etc., separately containing various active compositions such as safflower polysaccharides；It is pungent, warm-natured, the thoughts of returning home, Liver Channel；Can invigorate blood circulation, dispel The stasis of blood is relieved pain；Cure mainly blood stasis, dysmenorrhoea, postpartum stasis stomachache, chest impediment and cardialgia, lumps in the chest and abdomen, traumatic injury, arthralgia, in Windage yaw paralysis etc.；Modern pharmacology proves that safflower has anticoagulation, anti-inflammatory, antioxidation etc., to a variety of bacterium such as Candida albicans Planting has antifungal activity.

It is windproof：For the windproof root of the windproof platymiscium of Umbelliferae；Contain for example windproof chromone alcohol of chromone constituents etc., Coumarins Composition such as bergapten, psoralen, phellopterin etc., polyacetylene constituents such as Panaxynol etc., for example windproof acid of polysaccharide component Property Polysaccharide A, C, volatile oil such as octanal etc., also containing plurality of active ingredients such as cupreol, vanillic acid, wogonins；Anti- local flavor Pungent, sweet, slightly warm in nature returns bladder, lung, the spleen channel；Can expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, only convulsion, antipruritic；Cure mainly catch cold, polarization head Bitterly, arthralgia pain due to rheumatism, stomachache diarrhea, discharging fresh blood stool, lockjaw, child convulsion, kite itch, sore from the beginning of etc.；Modern pharmacology Prove windproof with antipyretic cooling, analgesia, calm, anticonvulsion, anti-inflammatory, antibacterial, antitumor action etc..Document report is windproof more Sugared Contained Serum has the effect of regulation body's immunity, windproof to have certain antibacterial activity to fungi.

Radix bupleuri：For Umbelliferae Bupleunim. L radix bupleuri or the root of radix bupleuri scorzoneraefolii；Containing for example o- metoxyphenol of volatile oil, Eugenol, cresols etc., saponin component such as saikosaponin a, b₂、b₃, c etc., for example rutin, Quercetin etc. are a variety of has for flavonoids Imitate composition；Radix bupleuri bitter, pungent, cold nature, Return liver, gallbladder channel；Energy inducing diaphoresis is brought down a fever, soothing liver-qi stagnation, liter lift yang-energy；Cure mainly diseases caused by external factors hair Heat, fevers and chills alternate, malaria, liver-depressed hypochondrium pain mammary swelling, headache are dizzy etc.；Modern pharmacology prove radix bupleuri there is anti-inflammatory, it is antitumor, anti- The effects such as bacterium, antiviral, antipyretic, calm, analgesia, antibechic, there is regulation to make liver, intestines and stomach, immunologic function, blood fat etc. With.

Radix glycyrrhizae：For pulse family glycyrrhiza genus radix glycyrrhizae, smooth bark radix glycyrrhizae, swollen fruit Radix root and rhizome；Containing triterpenoid saponin such as Glycyrrhizin, Glycyrrhiza Uralensis saponin A, B etc., flavone compound such as 4',7-Dihydroxyflavanone, liquiritin etc., coumarin kind compound is such as Glycycoumarin, glycyol etc., alkaloids such as quinolines, iloquinoline derivative etc., polysaccharide such as radix glycyrrhizae glucan GBW, licorice polysaccharide UA, UB, UC etc., also containing plurality of active ingredients such as radix glycyrrhizae benzofuran, n-tricosanes；Radix glycyrrhizae is sweet, mild-natured, returns spleen, stomach, The heart, lung channel；Can be with middle emergency, moistening lung, removing toxic substances, coordinating the drug actions of a prescription；Process with control weakness of the spleen and the stomach, burnout deficiency of food, stomachache loose stool, four limbs contraction Anxious pain, palpitaition, hysteria, consumptive lung disease cough, it is raw with controlling abscess of throat, ulcerative carbuncle pyogenic infections, infant fetal toxin and medicine, food poisoning etc.； Modern pharmacology prove radix glycyrrhizae have antimicrobial, anti-inflammatory, antibechic, eliminating the phlegm, it is antitumor, it is anti-mutation, it is anti-oxidant the effects such as, offset Change system, cardiovascular system, reproductive system and brain, renal function etc. have adjustment effect.

A kind of Chinese medicine composition for being used to treat fungal keratitis after immunosupress, can be prepared into using conventional method The form of Chinese drug such as oral liquid, granule, pulvis, pill, tablet, capsule.The present invention provides a kind of preparation side of oral liquid medicine Method.

A kind of preparation method for being used to treat the Chinese medicine composition of fungal keratitis after immunosupress, including following step Suddenly：Each bulk drug is accurately taken according to parts by weight, is filtered after adding water to cook, filtrate is oral liquid medicine.

Specifically, the preparation method for treating the Chinese medicine composition of fungal keratitis after immunosupress, including it is following Step：

(1) with gram be parts by weight unit, accurately take each bulk drug, in addition to roud cardamon seed, remaining bulk drug add 1.5L water in, Immersion 30 minutes, turns slow fire fried 30 minutes after boiling by intense fire, filter and remove residue, and this is the first fried liquid；

(2) dregs of a decoction in step (1) are added in 1L water, turn slow fire after boiling by intense fire fried 20 minutes, add roud cardamon seed, Continue to decoct 25 minutes, filter and remove residue, this is the second fried liquid；Merge fried liquid twice, as treating after immunosupress The oral liquid medicine of fungal keratitis, is a daily dose.

The usage and consumption of oral liquid：The decoction of daily dosage, which divides 2~3 times, to be taken, and is taken within 1 hour after meal and is preferred, even served It is within 14th a course for the treatment of.

Beneficial effects of the present invention：

There is typical clinical manifestation after immunodepressant application：Spiritlessness and weakness, dizzy, sallow complexion, tinnitus burnout, Palpitation, abdominal distension, tongue nature is light dark, and arteries and veins is thin, similar to the traditional Chinese medical science " consumptive disease " category.Fungal keratitis is modern medicine name of disease, Main clinical manifestation is：Or itch or pain, photophobia sheds tears, and black eyeball gives birth to screen, and screen does not dissipate long, such as white congealed fat shape, sharpness of border or not Clearly, uneven surface, micro- protuberance, the visible pseudopodium of perilesional or satellite stove.The traditional Chinese medical science " black eyeball is belonged to according to its main clinical manifestation Screen " category.Fungal keratitis pathogenesis caused by immunosupress belongs to asthenia in origin and asthenia in superficiality, and this void is immunodepressant using drawing Rise, mark actually cornea fungal infection.This void belongs to spleen kidney deficiency, and deficiency of both qi and yin marks actually Shi Re Bing Pian and blood stasis.The present invention is exactly The Chinese medicine compound prescription provided with " kidney and spleen invigorating, supplementing qi and nourishing yin, clearing heat and promoting diuresis, removing toxic substances promoting blood circulation " for therapy, determined curative effect.

Chinese medicine composition of the present invention by astragalus root, Radix Codonopsis, rhizoma atractylodis macrocephalae, fry rhizoma atractylodis, cultivated land, Chinese yam, the fruit of Chinese wolfberry, the fruit of glossy privet, Totally 23 taste Chinese herbal medicine compatibilities are constituted for almond, roud cardamon seed etc.：The Radix Astragali is sweet in side, temperature, and return lung, the spleen channel are tonifying middle-Jiao and Qi key medicine, simultaneously It is apt to promoting pus discharge and tissue regeneration again.Radix Codonopsis is sweet, flat, returns spleen, lung channel, tonifying middle-Jiao and Qi, blood-nourishing of promoting the production of body fluid.Rhizoma atractylodis macrocephalae：Bitter, sweet, temperature, returns spleen, stomach, Air making-up and spleen enlivening, eliminate dampness and have diuretic effect.Stir-fry rhizoma atractylodis are pungent, hardship, temperature, returns spleen, stomach, Liver Channel, drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.Cultivated land is sweet, Tepor, returns liver and kidney channel, nourishing the blood and yin, enriching essence and nourishing marrow.Chinese yam is sweet, flat, returns spleen, lung, kidney channel, supplementing qi and nourishing yin, help spleen and lung, mends Kidney controlling nocturnal emission with astringent drugs.The fruit of Chinese wolfberry is sweet, flat, Return liver, kidney, lung channel, nourishing liver and kidney, improving eyesight.The fruit of glossy privet is sweet, bitter, cool, returns liver and kidney channel, help liver Kidney, heat-clearing improving eyesight.Upper seven tastes Chinese medicine is for the spleen kidney deficiency of this disease this void, deficiency of both qi and yin, gather altogether kidney and spleen invigorating, supplementing qi and nourishing yin it Work(.Almond is pungent, bitter in side, tepor, and Return liver, large intestine channel open lung qi, makes damp evil from upper and solve；Roud cardamon seed is pungent, temperature, return lung, spleen, Stomach, dampness elimination, promoting the circulation of qi, middle benefit gas, preventing or arresting vomiting.Semen Coicis are sweet, light, are slightly cold, returns spleen, stomach, lung channel, take its clearing damp and promoting diuresis, clearing away heat and eliminating pus The effect of.Three benevolence are shared, can declare, it is smooth in, ooze lower and have eliminating dampness and heat, declare the work(of smooth three burnt mechanisms of qi.The bark of official magnolia is bitter, pungent, temperature, returns Spleen, stomach, lung, large intestine channel, eliminating dampness promoting the circulation of qi, relieving asthma.The leaf of bamboo is sweet light, trembles with fear, enters the heart, lung, courage, stomach, can clearing heat-fire, only tear Diuresis.Almond, cool benevolence, coix seed, the bark of official magnolia and the leaf of bamboo are directed to the damp and hot interpretation of the cause, onset and process of an illness, the work(with clearing heat and promoting diuresis in side.Honeysuckle in side It is sweet, cold, return lung, the heart, stomach, large intestine channel, clearing heat and detoxicating, dispelling wind and heat from the body.Chrysanthemum indicum is pungent, sweet, bitter, be slightly cold, return lung, Liver Channel, evacuation Wind-heat, clears liver and improve vision.Dandelion is sweet, bitter, cold, Return liver, stomach, clearing heat and detoxicating, carbuncle that disappears dissipating bind.Honeysuckle, chrysanthemum indicum and Pu are public English is for this sick evil cause of disease of fungi poison, the work(with heat-clearing antivirus.The root of herbaceous peony is bitter, sour in side, be slightly cold, and enter liver, the spleen channel are enriched blood and held back It is cloudy.Radix Angelicae Sinensis is sweet, pungent, temperature, and Return liver, the heart, the spleen channel are enriched blood, invigorated blood circulation.Ligusticum wallichii is pungent, temperature, enter liver, courage, pericardium channel, blood-activating and qi-promoting.Safflower Pungent, temperature, the thoughts of returning home, Liver Channel are promoting blood circulation and removing blood stasis, stimulate the menstrual flow.Cultivated land, the root of herbaceous peony, Radix Angelicae Sinensis, Ligusticum wallichii composition Siwu Tang, are that blood-supplementing blood-nourishing is lived in side The classical prescription of blood, adds safflower nourshing blood and promoting blood circulation, for this sick pathogenesis of blood stasis.Windproof pungent, sweet, tepor in side, return bladder, Liver, the spleen channel, expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, spasmolysis.Radix bupleuri is bitter, pungent, be slightly cold, and Return liver, gallbladder channel, inducing diaphoresis are brought down a fever, soothing liver-qi stagnation, rises Lift yang-energy.Windproof in side, radix bupleuri be used as guiding drug, priming it is up enter mesh.Radix glycyrrhizae is sweet, flat, the thoughts of returning home, lung, spleen, stomach, tonifying spleen benefit Gas, clearing heat and detoxicating, coordinating the drug actions of a prescription.Through modern pharmacological research, the Radix Astragali, rhizoma atractylodis, the fruit of glossy privet, honeysuckle, chrysanthemum indicum, Pu Gong in we English, the root of herbaceous peony, Ligusticum wallichii, safflower, windproof there is antifungic action.

Spleen kidney deficiency that Chinese medicine composition of the present invention occurs after both being applied for immunodepressant, deficiency of both qi and yin and damp and hot The card of hemostasis, the side's of sending medication is with kidney and spleen invigorating, supplementing qi and nourishing yin, and clearing heat and promoting diuresis, promoting blood circulation are again evil for infection fungi poison, weight Carried out with the medicine for killing fungi clearing heat and detoxicating.Full policy is treated both principal and secondary aspect of disease to the complicated interpretation of the cause, onset and process of an illness.Medication has following characteristics：(1) righting Eliminating evil makes eliminating evil not hinder just with using；(2) spleen kidney is with mending, and the benefit benefit day after tomorrow is congenital；(3) using medicines of both cold and hot natures simultaneously, makes full side warm but not dry, clear Without cold；(4) promoting blood circulation is not forgotten to enrich blood, dissolving stasis not blood trouble；(5) medication both meets traditional Chinese medical theory, there is modern pharmacological research again Support, finally make we into efficient, gentle agent.

The present invention uses pure natural Chinese herbal medicine, and medicine source is abundant, medicine valency is cheap, has no toxic side effect, and preparation method is simple, is suitable to Large-scale industrial production.

Embodiment

Following embodiments are only described in further detail to the present invention, do not constitute any limitation of the invention.

Embodiment 1

It is used for the Chinese medicine composition for treating fungal keratitis after immunosupress in the present embodiment, by following parts by weight Bulk drug is constituted：30 parts of astragalus root, 30 parts of Radix Codonopsis, 12 parts of rhizoma atractylodis macrocephalae, 9 parts of rhizoma atractylodis of stir-fry, 15 parts of cultivated land, 30 parts of Chinese yam, the fruit of Chinese wolfberry 12 parts, 12 parts of the fruit of glossy privet, 9 parts of semen armeniacae amarae, 6 parts of roud cardamon seed, 30 parts of coix seed, 12 parts of lophatherum gracile, 9 parts of the bark of official magnolia, 12 parts of honeysuckle, 15 parts of chrysanthemum indicum, 15 parts of dandelion, 15 parts of the root of herbaceous peony, 12 parts of Radix Angelicae Sinensis, 9 parts of Ligusticum wallichii, 9 parts of safflower, windproof 9 parts, 9 parts of radix bupleuri, radix glycyrrhizae 9 Part.

It is used to treating the preparation method of the Chinese medicine composition of fungal keratitis after immunosupress in the present embodiment, including with Lower step：

(1) with gram be parts by weight unit, accurately take each bulk drug, in addition to roud cardamon seed, remaining bulk drug add 1.5L water in, Immersion 30 minutes, turns slow fire fried 30 minutes after boiling by intense fire, filter and remove residue, and this is the first fried liquid；

(2) dregs of a decoction in step (1) are added in 1L water, turn slow fire after boiling by intense fire fried 20 minutes, add roud cardamon seed, Continue to decoct 25 minutes, filter and remove residue, this is the second fried liquid；Merge fried liquid twice, as treating after immunosupress The oral liquid medicine of fungal keratitis, is a daily dose.

The usage and consumption of oral liquid：The decoction of daily dosage, which divides 2~3 times, to be taken, and is taken within 1 hour after meal and is preferred, even served It is within 14th a course for the treatment of.

Embodiment 2

It is used for the Chinese medicine composition for treating fungal keratitis after immunosupress in the present embodiment, by following parts by weight Bulk drug is constituted：20 parts of astragalus root, 20 parts of Radix Codonopsis, 10 parts of rhizoma atractylodis macrocephalae, 6 parts of rhizoma atractylodis of stir-fry, 12 parts of cultivated land, 20 parts of Chinese yam, the fruit of Chinese wolfberry 10 parts, 10 parts of the fruit of glossy privet, 6 parts of semen armeniacae amarae, 6 parts of roud cardamon seed, 20 parts of coix seed, 10 parts of lophatherum gracile, 6 parts of the bark of official magnolia, 10 parts of honeysuckle, 10 parts of chrysanthemum indicum, 10 parts of dandelion, 12 parts of the root of herbaceous peony, 10 parts of Radix Angelicae Sinensis, 6 parts of Ligusticum wallichii, 6 parts of safflower, windproof 6 parts, 6 parts of radix bupleuri, radix glycyrrhizae 6 Part.

It is used for the preparation method and medicine for treating the Chinese medicine composition of fungal keratitis after immunosupress in the present embodiment The usage and dosage be the same as Example 1 of thing.

Embodiment 3

It is used for the Chinese medicine composition for treating fungal keratitis after immunosupress in the present embodiment, by following parts by weight Bulk drug is constituted：9 parts of astragalus root, 9 parts of Radix Codonopsis, 6 parts of rhizoma atractylodis macrocephalae, fry 3 parts of rhizoma atractylodis, 9 parts of cultivated land, 15 parts of Chinese yam, 6 parts of the fruit of Chinese wolfberry, 6 parts of the fruit of glossy privet, 6 parts of semen armeniacae amarae, 3 parts of roud cardamon seed, 9 parts of coix seed, 6 parts of lophatherum gracile, 3 parts of the bark of official magnolia, 6 parts of honeysuckle, chrysanthemum indicum 9 Part, 9 parts of dandelion, 6 parts of the root of herbaceous peony, 6 parts of Radix Angelicae Sinensis, 3 parts of Ligusticum wallichii, 3 parts of safflower, windproof 6 parts, 3 parts of radix bupleuri, 3 parts of radix glycyrrhizae.

It is used for the preparation method and medicine for treating the Chinese medicine composition of fungal keratitis after immunosupress in the present embodiment The usage and dosage be the same as Example 1 of thing.

Embodiment 4

It is used for the Chinese medicine composition for treating fungal keratitis after immunosupress in the present embodiment, by following parts by weight Bulk drug is constituted：15 parts of astragalus root, 15 parts of Radix Codonopsis, 9 parts of rhizoma atractylodis macrocephalae, 6 parts of rhizoma atractylodis of stir-fry, 10 parts of cultivated land, 20 parts of Chinese yam, the fruit of Chinese wolfberry 9 Part, 9 parts of the fruit of glossy privet, 6 parts of semen armeniacae amarae, 6 parts of roud cardamon seed, 15 parts of coix seed, 9 parts of lophatherum gracile, 6 parts of the bark of official magnolia, 9 parts of honeysuckle, mother chrysanthemum Spend 12 parts, 9 parts of dandelion, 12 parts of the root of herbaceous peony, 9 parts of Radix Angelicae Sinensis, 6 parts of Ligusticum wallichii, 6 parts of safflower, windproof 6 parts, 6 parts of radix bupleuri, 6 parts of radix glycyrrhizae.

It is used for the preparation method and medicine for treating the Chinese medicine composition of fungal keratitis after immunosupress in the present embodiment The usage and dosage be the same as Example 1 of thing.

Embodiment 5

It is used for the Chinese medicine composition for treating fungal keratitis after immunosupress in the present embodiment, by following parts by weight Bulk drug is constituted：12 parts of astragalus root, 12 parts of Radix Codonopsis, 10 parts of rhizoma atractylodis macrocephalae, 6 parts of rhizoma atractylodis of stir-fry, 9 parts of cultivated land, 15 parts of Chinese yam, the fruit of Chinese wolfberry 9 Part, 6 parts of the fruit of glossy privet, 6 parts of semen armeniacae amarae, 6 parts of roud cardamon seed, 12 parts of coix seed, 6 parts of lophatherum gracile, 6 parts of the bark of official magnolia, 10 parts of honeysuckle, mother chrysanthemum Spend 10 parts, 10 parts of dandelion, 12 parts of the root of herbaceous peony, 10 parts of Radix Angelicae Sinensis, 6 parts of Ligusticum wallichii, 3 parts of safflower, windproof 6 parts, 6 parts of radix bupleuri, 6 parts of radix glycyrrhizae.

It is used for the preparation method and medicine for treating the Chinese medicine composition of fungal keratitis after immunosupress in the present embodiment The usage and dosage be the same as Example 1 of thing.

Clinical test

1st, diagnostic criteria

There are immunodepressant or glucocorticoid medication history, with fungal keratitis clinical manifestation, and through cornea Scraping blade or the confocal observation of cornea live body or cornea scraping blade positive for fungi culture person.

2nd, state of an illness weight grade scale

Slightly：Ulcer of the cornea area≤4mm², ulcer range table is shallow, not with hypopyon；

Moderate：Ulcer of the cornea diameter ＞ 4mm²But≤15mm², ulcer depth reaches the 50% of corneal thickness, with anterior chamber's product Purulence；

Severe：Ulcer of the cornea diameter ＞ 15mm², ulcer depth exceedes corneal thickness 75%, with hypopyon.

3rd, packet and treatment method

Include case and carry out layering packet according to state of an illness weight, be respectively allocated in Western medicine group and Chinese medicine group.Western medicine group is given Give 5% Natamycin eye drops eye drip, 1 time/1h；The Chinese herbs decoction of the daily oral embodiment 2 of Chinese medicine group, two times a day.It is within 14 days After one course for the treatment of, 4 courses for the treatment of of medication, curative effect is judged.

4th, case rejects standard

A, not by regulation medication, it is impossible to judge curative effect person；

The infull person of b, data collection；

There is acute infection to influence result judgement person during c, experiment.

5th, curative effect determinate standard

Cure：Corneal irritation disappears, and ulcer surface healing, cornea fluorescent staining is negative, and hypopyon disappears, and live body is common Burnt cornea scanning fungi disappears；

Take a turn for the better：Irritation mitigates, and ulcer area reduces limitation, and hypopyon is reduced or disappeared；

It is invalid：Focus is unchanged, and various symptoms are without improving or aggravating, and ulcer aggravates or perforated.

6th, interpretation of result

(1) Western medicine group is compared with Chinese medicine group patient's ordinary circumstance

The patient of Western medicine group and Chinese medicine group uses from, sex, age, immunodepressant and glucocorticoid, the state of an illness point Level aspect is compared, and no significant difference (P ＞ 0.05), two groups of results have comparativity.General clinical data situation is shown in Table 1.

The Western medicine group of table 1 is compared with Chinese medicine group patient's ordinary circumstance

(2) Western medicine group is compared with Chinese medicine group therapeutic effect

The Western medicine group of table 2 is compared with Chinese medicine group therapeutic effect

Conclusion：Treat after four courses for the treatment of, two groups of patient clinical symptoms and sign are improved in varying degrees, ulcer of the cornea face Product reduces, hypopyon absorbs, and leaves different degrees of hickie or nubecula.The total effective rate of its Chinese and Western medicine group is 76.6%, The total effective rate of Chinese medicine group is 90.4%, and the total effective rate of Chinese medicine group significantly improves (P ＜ 0.05) compared with Western medicine group, is shown in Table 2.

Model case

Case 1：Zhang, female 35 years old, with the slight foreign body sensation of left eye, goes to a doctor for about 3 weeks with visual impairment.Patient's eye pain, Photophobia, the irritation such as shed tears be not obvious, sees under slit-lamp：Conjunctiva mixed congestion, ulcer of the cornea, area about 7mm², focus week Corneal edema, focus are enclosed in canescence congealed fat shape, sharpness of border, the micro- protuberance in surface, the visible pseudopodium of perilesional.The confocal inspection of live body Look into discovery fungi.Interrogation finds that patient suffers from lupus erythematosus and taken prednisone 3 months, no cornea trauma history.Obvious Ke of patient Emerging face, Mian Se Koushi are white, with tired, abdominal fullness and distention, and Huang of urinating just is tied, and bitter taste halitosis, pale tongue is dark, red tongue margin, and yellow tongue fur is thick It is greasy, thready rapid pulse.Card category speen-kidney dificiency, with liver and gall heated, showing tremendous enthusiasm upper inflammation.Treat the oral medicine prepared with the embodiment of the present invention 2 Liquid, two times a day, advises further consultation after 1 week；Two foreign body sensations of eye when examining mitigate, and ulcer of the cornea area reduces, and live body is confocal to be checked Fungi tails off, tired, abdominal fullness and distention, and bitter taste halitosis mitigates, and pale tongue is dark, and tongue side point is red, yellow and greasy fur, thready rapid pulse.The state of an illness subtracts Gently, effectively, defence is constant, advises 2 Zhou Houzai to examine for prescription.Three eye's subjective symptoms when examining substantially mitigate, eyesight increase, cornea Ulcer area reduces, and focus becomes flat, and live body is confocal to can not find fungi, and fungal culture is negative, and patient feels strength increase, complexion Slightly gloss, thick greasy fur mitigates, and defence is constant, advises further consultation after 3 weeks.Eye's subjective symptoms disappears during the four methods of diagnosis, and eyesight is extensive Multiple, ulcer of the cornea disappears, and focus absorbs, and fluorescent staining is negative, and live body is confocal to can not find fungi, and fungal culture is negative, patient Complexion slightly gloss, thick greasy fur mitigates, and defence is constant, continues with a course for the treatment of.Follow-up 1 year, does not recur afterwards.

Case 2：Jiao, man 20 years old, is gone to a doctor for about 3 weeks with cornea of right eye ulcer.Patient's right eye foreign body sensation, pain, shed tears Irritation is not obvious, sees under slit-lamp：Conjunctiva mixed congestion, ulcer of the cornea, area about 8mm², perilesional corneal edema, Focus is in canescence congealed fat shape, the micro- protuberance in surface, the visible pseudopodium of perilesional.Cornea scraping blade finds fungi, and cornea culture is white Color monilial infection.Interrogation finds that patient suffers from nephrotic syndrome 3 years, Long-term Hormone, no cornea trauma history.Patient is obvious Ke Xing faces, face color Koushi is white, and with tired, abdominal fullness and distention, urine is yellow, and bitter taste halitosis, pale tongue is dark, and tongue side point is red, tongue Greasy, the thready rapid pulse of yellow thickness.Card category speen-kidney dificiency, with liver and gall excess heat.Treat the oral liquid medicine prepared with the embodiment of the present invention 1, one It 2 times, advise further consultation after 2 weeks；Two foreign body sensations of eye when examining mitigate, and ulcer of the cornea area reduces, and the confocal inspection of live body is not sent out Existing fungi, tired, abdominal fullness and distention, bitter taste halitosis mitigates, and pale tongue is dark, red tip of tongue, yellow and greasy fur, thready rapid pulse.The state of an illness mitigates, side Effectively, defence is constant, advises 2 Zhou Houzai to examine for medicine.Three eye's subjective symptoms when examining substantially mitigate, and ulcer of the cornea area continues to contract Small, ulcer stove is flat, and live body is confocal not to find fungi, and fungal culture is negative, and patient mental takes a turn for the better, and thick greasy fur mitigates, defence It is constant, advise further consultation after 3 weeks.Eye's subjective symptoms disappears during the four methods of diagnosis, vision restoration, and ulcer of the cornea disappears, and focus absorbs, glimmering Light element is negative staining.Defence is constant, continues and is consolidated with a course for the treatment of.Follow-up 2 years, do not recur afterwards.

Claims (3)

1. a kind of Chinese medicine composition for being used to treat fungal keratitis after immunosupress, it is characterised in that：By following parts by weight Several Chinese medicine material compositions：9~30 parts of astragalus root, 9~30 parts of Radix Codonopsis, 6~12 parts of rhizoma atractylodis macrocephalae, 3~9 parts of rhizoma atractylodis of stir-fry, cultivated land 9~ 15 parts, 15~30 parts of Chinese yam, 6~12 parts of the fruit of Chinese wolfberry, 6~12 parts of the fruit of glossy privet, 6~9 parts of semen armeniacae amarae, 3~6 parts of roud cardamon seed, Job's tears 9~30 parts of benevolence, 6~12 parts of lophatherum gracile, 3~9 parts of the bark of official magnolia, 6~12 parts of honeysuckle, 9~15 parts of chrysanthemum indicum, 9~15 parts of dandelion, 6~15 parts of the root of herbaceous peony, 6~12 parts of Radix Angelicae Sinensis, 3~9 parts of Ligusticum wallichii, 3~9 parts of safflower, windproof 6~9 parts, 3~9 parts of radix bupleuri, radix glycyrrhizae 3~9 Part.

2. a kind of preparation side as claimed in claim 1 for being used to treat the Chinese medicine composition of fungal keratitis after immunosupress Method, it is characterised in that：Comprise the following steps：Each bulk drug is accurately taken according to parts by weight, is filtered after adding water to cook, filtrate is Oral liquid medicine.

3. the preparation side according to claim 2 for being used to treat the Chinese medicine composition of fungal keratitis after immunosupress Method, it is characterised in that：Comprise the following steps：

(1) with gram be parts by weight unit, accurately take each bulk drug, in addition to roud cardamon seed, remaining bulk drug add 1.5L water in, immersion 30 minutes, turn slow fire after boiling by intense fire fried 30 minutes, filter and remove residue, this is the first fried liquid；

(2) dregs of a decoction in step (1) are added in 1L water, turns slow fire after boiling by intense fire fried 20 minutes, add roud cardamon seed, continued Decoct 25 minutes, filter and remove residue, this is the second fried liquid；Merge fried liquid twice, produce oral liquid medicine.