CN105079488A - Traditional Chinese medicine for treating whitlow, and preparation method thereof - Google Patents
Traditional Chinese medicine for treating whitlow, and preparation method thereof Download PDFInfo
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- CN105079488A CN105079488A CN201510620910.4A CN201510620910A CN105079488A CN 105079488 A CN105079488 A CN 105079488A CN 201510620910 A CN201510620910 A CN 201510620910A CN 105079488 A CN105079488 A CN 105079488A
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Abstract
The invention provides a traditional Chinese medicine for treating whitlow and a preparation method thereof. The traditional Chinese medicine comprises the following active pharmaceutical ingredients: cyathea spinulosa Wall., Chinese umbrellaleaf rhizome and root, herb of heterophyllous eupatoriu, aspidistra typica, allophylus viridis, all-grass of ames vanda, hymenocallis speciosa, leaf of littelleaf paraquilegia, root or stem of climbing rhaphidophora, giantleaf ardisia rhizome, chloranthus serratus, starjasmine stem, heracleum millefolium Diels and all-grass of elatostema stewardii. The traditional Chinese medicine has an exact efficacy of treating whitlow, and the side effect is little.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to one and treating paronychial Chinese medicine and preparation method thereof.
Background technology
The growing part of fingernail claims onychostroma or nail root, covered by skin, the both sides of fingernail connect with skinfold, form nail groove, the pyogenic infection of paronychia and both sides, nail plate and skinfold joint portion is one of clinical common finger (toe) portion infectious disease.Paronychia is many caused by infection of staphylococcus aureus, and streptococcus, Pseudomonas bacillus pyocyaneus, escherichia coli and proteus vulgaris also can be caused a disease.Primary disease is often secondary to wound, tear, bite, repair finger (toe) first after, but also with or without obvious partial trauma history person.Skin lesion is sent out in nail groove place, and cardinal symptom is local redness, suppuration, diabrosis, scorching hot, pain.
It is subcutaneous that paronychia often first occurs in side nail groove, shows as Ipsilateral red swelling of the skin, pain, general many without systemic infection symptom, if pathological development, intralesional becomes pus, has fluctuation in red and swollen district, there is white point, but not easily ulceration comes to a head, inflammation also can betide nail root place or expand to opposite side nail groove, and infecting to have that the pain increased and General Symptoms such as heating grade when increasing the weight of, because fingernail hinders purulence thing to discharge, infection can spread to deep layer and form dactylitis.The near-end of finger and toe nail side or bilateral nail groove is rubescent, swelling, pain, then occurs pus point, visible granulation tissue after suppurating.When outbreaks of infection is to nail matrix, local empyema can make whole finger, and toenail floats, and comes off.
Acute paronychia: after often occurring in injured or minor trauma, feature shows as the pyogenic infection with pain, and acute abscess forms (staphylococcus) or erythema and swelling (streptococcus).
Chronic paronychia: often by minor trauma repeatedly and be exposed in water, stimulus object and allergin and cause dermatitis, then yeast field planting occurs, secondary bacterial infection.Clinical symptoms is the inflammation of near-end nail fold, and show as pain property erythema, edema, nail cuticle lacks, and nail matrix damage causes deck surface abnormal.The chronic course of disease, with self limiting acute exacerbation is overlapping repeatedly.Sometimes also can there is the performance of similar chronic paronychia in tumor, as bowen's disease, keratoacanthoma, squamous cell carcinoma, enchondroma and amelanotic melanoma.Paronychia and false purulent granuloma may be there is, as system application retinoid medicine, anti-retroviral medicine, anti-epidermal growth factor antibody and epidermal growth factor tyrosine kinase inhibitor when taking some drugs.Also can cause, as ingrowing nail, cutaneous leishmaniasis etc. because of some rare reasons.
Summary of the invention
Technical problem to be solved by this invention is, provide one to treat paronychial Chinese medicine and preparation method thereof, Chinese medicine of the present invention, have definite curative effect to paronychia, side effect is little.
In order to solve the problems of the technologies described above, the invention provides one and treat paronychial Chinese medicine, its raw medicinal material comprises: Caulis cyatheae spinulosae, Rhizoma et Radix Diphylleiae, Herba Eupatorii Heterophylli, ovum leaf Rhizoma aspidistrae elatioris, Radix Allophylli Viridis, Vanda amesiana Reichb. F, water ghost any of several broadleaf plants, Folium Paraquilegiae microphyllae, Radix Seu Caulis Rhaphidophorae Decursivae, Rhizoma Ardisiae Gigantifoliae, Radix Chloranthi Serrati, Caulis Trachelospermi, Chiba Radix Angelicae Pubescentis and Rhizoma Polygoni sinensis.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Caulis cyatheae spinulosae 25 ~ 35 parts, Rhizoma et Radix Diphylleiae 25 ~ 40 parts, Herba Eupatorii Heterophylli 30 ~ 40 parts, ovum leaf Rhizoma aspidistrae elatioris 25 ~ 35 parts, Radix Allophylli Viridis 20 ~ 30 parts, Vanda amesiana Reichb. F 25 ~ 35 parts, water ghost any of several broadleaf plants 20 ~ 30 parts, Folium Paraquilegiae microphyllae 15 ~ 25 parts, Radix Seu Caulis Rhaphidophorae Decursivae 30 ~ 40 parts, Rhizoma Ardisiae Gigantifoliae 20 ~ 30 parts, Radix Chloranthi Serrati 5 ~ 15 parts, Caulis Trachelospermi 10 ~ 25 parts, Chiba Radix Angelicae Pubescentis 20 ~ 30 parts and Rhizoma Polygoni sinensis 5 ~ 15 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Caulis cyatheae spinulosae 25 ~ 30 parts, Rhizoma et Radix Diphylleiae 30 ~ 35 parts, Herba Eupatorii Heterophylli 35 ~ 40 parts, ovum leaf Rhizoma aspidistrae elatioris 25 ~ 30 parts, Radix Allophylli Viridis 20 ~ 25 parts, Vanda amesiana Reichb. F 25 ~ 30 parts, water ghost any of several broadleaf plants 20 ~ 25 parts, Folium Paraquilegiae microphyllae 15 ~ 20 parts, Radix Seu Caulis Rhaphidophorae Decursivae 30 ~ 35 parts, Rhizoma Ardisiae Gigantifoliae 25 ~ 30 parts, Radix Chloranthi Serrati 5 ~ 10 parts, Caulis Trachelospermi 15 ~ 25 parts, Chiba Radix Angelicae Pubescentis 20 ~ 25 parts and Rhizoma Polygoni sinensis 5 ~ 10 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Caulis cyatheae spinulosae 28 parts, Rhizoma et Radix Diphylleiae 32 parts, Herba Eupatorii Heterophylli 36 parts, ovum leaf Rhizoma aspidistrae elatioris 28 parts, Radix Allophylli Viridis 25 parts, Vanda amesiana Reichb. F 30 parts, water ghost any of several broadleaf plants 23 parts, Folium Paraquilegiae microphyllae 19 parts, Radix Seu Caulis Rhaphidophorae Decursivae 32 parts, Rhizoma Ardisiae Gigantifoliae 25 parts, Radix Chloranthi Serrati 7 parts, Caulis Trachelospermi 18 parts, Chiba Radix Angelicae Pubescentis 22 parts and Rhizoma Polygoni sinensis 8 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Caulis cyatheae spinulosae 26 parts, Rhizoma et Radix Diphylleiae 35 parts, Herba Eupatorii Heterophylli 38 parts, ovum leaf Rhizoma aspidistrae elatioris 25 parts, Radix Allophylli Viridis 22 parts, Vanda amesiana Reichb. F 27 parts, water ghost any of several broadleaf plants 21 parts, Folium Paraquilegiae microphyllae 16 parts, Radix Seu Caulis Rhaphidophorae Decursivae 35 parts, Rhizoma Ardisiae Gigantifoliae 28 parts, Radix Chloranthi Serrati 8 parts, Caulis Trachelospermi 20 parts, Chiba Radix Angelicae Pubescentis 20 parts and Rhizoma Polygoni sinensis 7 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is liniment, and its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;
Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds weight portion 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is membranous patch, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, powder 6.5 ~ 7.5 weight portion prepared by the first step, polyvinyl alcohol 2 ~ 3 weight portion, the abundant mix and blend of glycerol 0.5 ~ 1 weight portion, produces to without minute bubbles, leaves standstill 20 ~ 30 minutes, obtained mixing paste;
3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.
Beneficial effect of the present invention: Chinese medicine of the present invention, have definite curative effect to paronychia, side effect is little.
Detailed description of the invention
The invention provides one and treat paronychial Chinese medicine, its raw medicinal material comprises: Caulis cyatheae spinulosae, Rhizoma et Radix Diphylleiae, Herba Eupatorii Heterophylli, ovum leaf Rhizoma aspidistrae elatioris, Radix Allophylli Viridis, Vanda amesiana Reichb. F, water ghost any of several broadleaf plants, Folium Paraquilegiae microphyllae, Radix Seu Caulis Rhaphidophorae Decursivae, Rhizoma Ardisiae Gigantifoliae, Radix Chloranthi Serrati, Caulis Trachelospermi, Chiba Radix Angelicae Pubescentis and Rhizoma Polygoni sinensis.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Caulis cyatheae spinulosae: [another name] Caulis cyatheae spinulosae, thorn Caulis cyatheae spinulosae, Shan Qin Liao, mountain palm fibre, Os Draconis wind, tree fern, large Rhizoma Osmundae.For Cyatheaceae Caulis cyatheae spinulosae platymiscium Caulis cyatheae spinulosae CyatheaspinulosaWall., be used as medicine with trunk.The whole year can adopt, and the hard crust of trunk of pruning, section is dried.[nature and flavor] micro-hardship, flat.[function cures mainly] expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, clearing and antitussive.For rheumatic arthritis, traumatic injury, chronic bronchitis, cough due to lung-heat, oedema due to nephritis, prevention influenza; Put on the skin outside juice in stem and control ringworm.
Rhizoma et Radix Diphylleiae: [another name] Ah ERQI, nest ginseng, early lotus, Ligularia nelumbifolia(Bur. et Franch.) Hand.-Mazz., Rhizoma Arisaematis.[source] medical material Ji Yuan: be Berberidaceae plant China unmrellaleaf and the root and rhizome of northeast unmrellaleaf.Gather and store: autumn excavates, cleaning, removing residual stem and palpus shape root.Dry or use of drying in the shade.[nature and flavor] are bitter; Pungent; Property is put down.[return through] liver; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Blood circulation promoting and blood stasis dispelling; Expelling wind and removing dampness.Main air pain of dampness syndrome; Traumatic injury; Menoxenia; Lower abdomen pain; Venom; Carbuncle furuncle
Herba Eupatorii Heterophylli: [another name] Huang Lihua, Rhizoma seu Herba Elatostematis stewardii, Herba Lycopi, little Rhizoma Cimicifugae, golden hair Radix Notoginseng, the pellet that helps digestion, three angular bits, water Rhizoma Cimicifugae, Rhizoma Schizocapsae Plantagineae, Cibotium barometz (L.) J. Sm., black sufficient Rhizoma Cimicifugae.[source] medical material Ji Yuan: be the rhizome of saxifragaceae plant Herba astilbes chinensis and large Herba astilbes chinensis.[nature and flavor] acrid in the mouth, hardship, warm in nature.[return through] Liver Channel.[function cures mainly] promoting blood circulation and stopping pain, expelling wind and removing dampness, strengthening the tendons and bones, removing toxic substances.。Main amenorrhea; Lump in the abdomen; Traumatic injury; Orchitis; Venom.
Ovum leaf Rhizoma aspidistrae elatioris: [another name] Rhizoma aspidistrae typicae, Rhizoma aspidistrae elatioris.[source] medical material Ji Yuan: be the rhizome of liliaceous plant ovum leaf Rhizoma aspidistrae elatioris.Gather and store: the whole year all can gather, clean, using fresh herb or section are dried.[nature and flavor] bitter in the mouth; Pungent; Slightly warm in nature.[function cures mainly] promoting blood circulation to remove blood stasis; Bone-setting pain stopping; Antidote against snake bite.Main air pain of dampness syndrome; Deficiency of the kidney lumbago; Traumatic injury; Venom.
Radix Allophylli Viridis: [another name] large fruit.[source] medical material Ji Yuan: be root, stem, the leaf of sapindaceous plant Radix Allophylli Viridis.Latin plant animal mineral name: AllophylusviridisRadlk. gathers and stores: summer, autumn gather, cleans, dries.[nature and flavor] are sweet; Temperature.[return through] kidney channel.[function cures mainly] expelling wind and removing dampness; Promoting blood circulation to remove blood stasis.Main air pain of dampness syndrome; Traumatic injury.
Vanda amesiana Reichb. F: [another name] Rhizoma seu Herba Elatostematis stewardii, Qian Tailou, the heart are dead, Herba Lysionoti Pauciflori, vanda, Ka Lujiao, bracketplant.[source] medical material Ji Yuan: be the herb of orchid Vanda amesiana Reichb. F.Latin plant animal mineral name: VandaamesianaReichb.f. gathers and stores: spring, summer gather, using fresh herb or dry.[nature and flavor] are sweet; Light; Property is put down.[return through] liver; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Dispel and mock dehumidifying; Blood circulation promoting and blood stasis dispelling.Main malaria; Laryngopharynx swelling and pain; Damp-heat gonorrhoea; Rheumatic arthralgia; Impairment caused by overstrain lumbago; Menoxenia; Traumatic injury; Fracture.
Water ghost any of several broadleaf plants: [another name] diversion any of several broadleaf plants, strongly fragrant any of several broadleaf plants.[source] medical material Ji Yuan: be the leaf of Bulbus Lycoridis Radiatae kind of plant Hymenocallis americana.Gather and store: summer, picking leaves in autumn, cleaning, chopping using fresh herb.[nature and flavor] are pungent; Temperature.[function cures mainly] relaxing muscles and tendons to promote blood circulation; Reducing swelling and alleviating pain.Main rheumatic arthritis; Treating swelling and pain by traumatic injury; Carbuncle skin ulcer swells; Hemorrhoid.
Folium Paraquilegiae microphyllae: [source] medical material Ji Yuan: be leaf or the aerial parts of ranunculaceae plant Folium Paraquilegiae microphyllae.Gather and store: the 7-8 month gathers, cleaning silt, remove residual leaf, deadwood, dry.[nature and flavor] bitter in the mouth; Puckery; Cold in nature.[return through] liver; Kidney; Spleen channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Sore is stopped blooding.Main traumatic injury; Amenorrhea; Dysmenorrhea; Traumatic hemorrhage; Incised wound; Wound disunion of a specified duration; Metrostaxis.
Radix Seu Caulis Rhaphidophorae Decursivae: [another name] Cayratia trifolia (L.) Domin, Acer buergerianum Miq．, Malong head lobe, fly Scolopendra, Red Triangle region maple, great Ye green grapes, little Radix Seu Caulis Rhaphidophorae Decursivae.[source] medical material Ji Yuan: for root or rattan that rattan and Zhi Nanya climb rattan are climbed in vitaceae Folium Trapae precipice.Gather and store: annual or autumn, winter gather, and clean, section, using fresh herb is dried.[nature and flavor] are pungent; Temperature.[function cures mainly] wind-damp dispelling; Dissipating blood stasis swells; Reuniting the fractured tendons and bones.Main rheumatic arthritis; Traumatic injury congestive edema; Fracture; Burn; Carbuncle skin ulcer is red and swollen.
Rhizoma Ardisiae Gigantifoliae: [another name] sends out greatly medicine, the Herba Blumeae Laciniatae, mountain Mus, blood maple, nine horses, road, mountain pig medicine.[source] medical material Ji Yuan: be the root and rhizome of Myrsinacea plant Rhizoma Ardisiae Gigantifoliae.Gather and store: autumn excavates, cleaning, using fresh herb, or section is dried.[nature and flavor] are bitter; Micro-pungent; Warm in nature.[function cures mainly] wind-damp dispelling; Promoting blood circulation and stopping pain; Removing toxic substances granulation promoting.Main air pain of dampness syndrome; Puerperal blood stasis; Carbuncle ulcer; Treating swelling and pain by traumatic injury.
Radix Chloranthi Serrati: [another name] Chloranthus multistachys Pei, the Herba Chloranthi holostegii(Herba chloranthi japonici), cattle Herba Asari, Radix Tylophorae arenicolae, hair leaf Herba Asari.[source] medical material Ji Yuan: be the root of Chloranthaceae plant Radix Chloranthi Serrati.Gather and store: excavating before blooming spring, removing stem Seedling, silt particle, dry in the shade.[nature and flavor] are bitter; Flat.[return through] Liver Channel.[function cures mainly] promoting blood circulation to remove blood stasis; Wind-expelling pain-stopping; Removing toxic substances parasite killing.Main traumatic injury; Fracture; Amenorrhea; Rheumatic arthralgia; Furuncle furuncle and phyma; Scabies; Skin pruritus; Venom.
Caulis Trachelospermi: [another name] stone dace, alum, outstanding stone, Yun Zhu, sea urchin roe paste, stone are consulted, omit stone, neck stone, SHILONG rattan, resistance to winter, stone blood, the red Caulis Trachelospermi of Radix Clematidis terniflorae, to leaf rattan, Caulis et Folium piperis, GUOQIANGFENG, parthenocissus, Shi Bangteng, tiger of sitting on the fence, Radix seu Caulis fici Martinii, folding GUCAO, handed over foot wind, Herba cynodontis, rattan network, water breakthrough raw, bitter even rattan, soft muscle rattan, ten thousand word gold silver, stone gas Citrus chachiensis Hort..[source] medical material Ji Yuan: be the leaf bine stem of apocynaceae plant trachelospermum jasminoide.Gather and store: planting after 3 ~ 4 years autumn Mo clip rattan, being cut into 25 ~ 30cm long, being bundled into wisp, drying.[nature and flavor] are bitter; Pungent; Cold nature.[return through] heart; Liver; Kidney channel.[function cures mainly] removing obstruction in the collateral to relieve pain; Heat clearing and blood cooling; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Soreness of waist and knee joint; The contracture of muscle arteries and veins; Laryngopharynx swelling and pain; Furuncle swelling toxin; Traumatic injury; Traumatic hemorrhage.
Chiba Radix Angelicae Pubescentis: [another name] Radix Heraclei dissecti, Heracleum millefolium Diels.[source] medical material Ji Yuan: be the herb of samphire decomposite leaf Radix Angelicae Pubescentis.Gather and store: gathering when the 7-8 month blooms, cleaning, dry.[nature and flavor] acrid in the mouth; Micro-sweet; Cold in nature.[function cures mainly] cooling blood for hemostasis; To dispel the wind removing toxic substances.Main traumatic hemorrhage; Grate is defeated in battle; Gingiva bleeding gingival hemorrhage; The dermal ecchymosis; Hematuria; Leprosy.(selecting from " China's book on Chinese herbal medicine ")
Rhizoma Polygoni sinensis: [another name] Herba Begoniae Laciniatae, red blood, the ring heart seven, Radix Pteroxygoni Giraldii, Rhizoma cypripedii macranthi, Herba asplenii prolongati, XUESANQI, blood Radix Sanguisorbae, wire inversion lotus.[source] medical material Ji Yuan: for the rhizome of stem knotweed is embraced by polygonaceae plant China.Gather and store: autumn excavates, cleaning, remove rough bark, using fresh herb or dry.[nature and flavor] acid; Bitter; Property is put down; Slightly poisonous.[function cures mainly] heat-clearing and toxic substances removing; Relaxing muscles and tendons to promote blood circulation; Promoting the circulation of QI to relieve pain; Hemostasia and promoting granulation.Main cold, fever; Laryngopharynx swelling and pain; Have loose bowels; Dysentery; Traumatic injury; Gastric abscess; Dysmenorrhea; Metrorrhagia; Traumatic hemorrhage.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Caulis cyatheae spinulosae 25 ~ 35 parts, Rhizoma et Radix Diphylleiae 25 ~ 40 parts, Herba Eupatorii Heterophylli 30 ~ 40 parts, ovum leaf Rhizoma aspidistrae elatioris 25 ~ 35 parts, Radix Allophylli Viridis 20 ~ 30 parts, Vanda amesiana Reichb. F 25 ~ 35 parts, water ghost any of several broadleaf plants 20 ~ 30 parts, Folium Paraquilegiae microphyllae 15 ~ 25 parts, Radix Seu Caulis Rhaphidophorae Decursivae 30 ~ 40 parts, Rhizoma Ardisiae Gigantifoliae 20 ~ 30 parts, Radix Chloranthi Serrati 5 ~ 15 parts, Caulis Trachelospermi 10 ~ 25 parts, Chiba Radix Angelicae Pubescentis 20 ~ 30 parts and Rhizoma Polygoni sinensis 5 ~ 15 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Caulis cyatheae spinulosae 25 ~ 30 parts, Rhizoma et Radix Diphylleiae 30 ~ 35 parts, Herba Eupatorii Heterophylli 35 ~ 40 parts, ovum leaf Rhizoma aspidistrae elatioris 25 ~ 30 parts, Radix Allophylli Viridis 20 ~ 25 parts, Vanda amesiana Reichb. F 25 ~ 30 parts, water ghost any of several broadleaf plants 20 ~ 25 parts, Folium Paraquilegiae microphyllae 15 ~ 20 parts, Radix Seu Caulis Rhaphidophorae Decursivae 30 ~ 35 parts, Rhizoma Ardisiae Gigantifoliae 25 ~ 30 parts, Radix Chloranthi Serrati 5 ~ 10 parts, Caulis Trachelospermi 15 ~ 25 parts, Chiba Radix Angelicae Pubescentis 20 ~ 25 parts and Rhizoma Polygoni sinensis 5 ~ 10 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Caulis cyatheae spinulosae 28 parts, Rhizoma et Radix Diphylleiae 32 parts, Herba Eupatorii Heterophylli 36 parts, ovum leaf Rhizoma aspidistrae elatioris 28 parts, Radix Allophylli Viridis 25 parts, Vanda amesiana Reichb. F 30 parts, water ghost any of several broadleaf plants 23 parts, Folium Paraquilegiae microphyllae 19 parts, Radix Seu Caulis Rhaphidophorae Decursivae 32 parts, Rhizoma Ardisiae Gigantifoliae 25 parts, Radix Chloranthi Serrati 7 parts, Caulis Trachelospermi 18 parts, Chiba Radix Angelicae Pubescentis 22 parts and Rhizoma Polygoni sinensis 8 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Caulis cyatheae spinulosae 26 parts, Rhizoma et Radix Diphylleiae 35 parts, Herba Eupatorii Heterophylli 38 parts, ovum leaf Rhizoma aspidistrae elatioris 25 parts, Radix Allophylli Viridis 22 parts, Vanda amesiana Reichb. F 27 parts, water ghost any of several broadleaf plants 21 parts, Folium Paraquilegiae microphyllae 16 parts, Radix Seu Caulis Rhaphidophorae Decursivae 35 parts, Rhizoma Ardisiae Gigantifoliae 28 parts, Radix Chloranthi Serrati 8 parts, Caulis Trachelospermi 20 parts, Chiba Radix Angelicae Pubescentis 20 parts and Rhizoma Polygoni sinensis 7 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is liniment, and its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;
Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds weight portion 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is membranous patch, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, powder 6.5 ~ 7.5 weight portion prepared by the first step, polyvinyl alcohol 2 ~ 3 weight portion, the abundant mix and blend of glycerol 0.5 ~ 1 weight portion, produces to without minute bubbles, leaves standstill 20 ~ 30 minutes, obtained mixing paste;
3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: liniment
Get Caulis cyatheae spinulosae 280g, Rhizoma et Radix Diphylleiae 320g, Herba Eupatorii Heterophylli 360g, ovum leaf Rhizoma aspidistrae elatioris 280g, Radix Allophylli Viridis 250g, Vanda amesiana Reichb. F 300g, water ghost any of several broadleaf plants 230g, Folium Paraquilegiae microphyllae 190g, Radix Seu Caulis Rhaphidophorae Decursivae 320g, Rhizoma Ardisiae Gigantifoliae 250g, Radix Chloranthi Serrati 70g, Caulis Trachelospermi 180g, Chiba Radix Angelicae Pubescentis 220g and Rhizoma Polygoni sinensis 80g;
Prepare according to the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;
Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 10 times amount soak by water 3 hours, filters and obtains decocting liquid; Second time adds weight portion 8 times amount soak by water 3 hours, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Embodiment 2: membranous patch
Get Caulis cyatheae spinulosae 260g, Rhizoma et Radix Diphylleiae 350g, Herba Eupatorii Heterophylli 380g, ovum leaf Rhizoma aspidistrae elatioris 250g, Radix Allophylli Viridis 220g, Vanda amesiana Reichb. F 270g, water ghost any of several broadleaf plants 210g, Folium Paraquilegiae microphyllae 160g, Radix Seu Caulis Rhaphidophorae Decursivae 350g, Rhizoma Ardisiae Gigantifoliae 280g, Radix Chloranthi Serrati 80g, Caulis Trachelospermi 200g, Chiba Radix Angelicae Pubescentis 200g and Rhizoma Polygoni sinensis 70g;
Prepare according to the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 60 object powder, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 200 object powder;
Second step, powder 7 weight portion prepared by the first step, polyvinyl alcohol 3 weight portion, the abundant mix and blend of glycerol 0.8 weight portion, produces to without minute bubbles, leaves standstill 30 minutes, obtained mixing paste;
3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.
Toxicity test:
1, experimental technique: evenly coated by depilatory guinea pig back spinal column both sides, makes unhairing scope about 30 square centimeters.Clean depilatory returns cage to observe 48 hours, is divided into four groups at random, often organizes 20, wherein three groups of Cavia porcelluss are coated with external liniment pure water diluent 0.4,0.8 and the 1.2ml of Chinese medicine embodiment 1 of the present invention respectively, respectively containing crude drug 78mg, 156mg and 234mg, another group is coated with solvent 0.8ml, every day three times, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.
2, result: above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, matched group no significant difference, histopathologic examination, the administration group heart, liver, kidney and depilation skin and the matched group more also no significant difference such as extremity are movable.
Result is pointed out, and Chinese medicine for external application of the present invention, without local irritant effect, also has no general toxicity performance.Show Chinese medicine for external application use safety of the present invention.
Clinical data:
Case selection: whole 88 routine cases are my Out-patient Department patient in February, 2014 ~ in June, 2015.Patient is divided into treatment group and matched group at random, wherein treatment group 44 people, male 24 people, women 20 people, 15 ~ 60 years old age, the course of disease 5 ~ 20 days; Acute paronychia 32 example, chronic paronychia 12 example; Site of pathological change: finger 29 example, toes 15 example; Pathogenic factor: dermatosis secondary infection causes 15 examples, repair finger (toe) first and cause 12 examples, ingrowing nail causes 7 examples, and pull out first agnail and cause 5 examples, cosmetics cause 5 examples.Matched group 44 people, male 25 people, women 19 people; 16 ~ 62 years old age, the course of disease 4 ~ 19 days; Acute paronychia 33 example, chronic paronychia 11 example; Site of pathological change: finger 30 example, toes 14 example; Pathogenic factor: dermatosis secondary infection causes 16 examples, repair finger (toe) first and cause 11 examples, ingrowing nail causes 8 examples, and pull out first agnail and cause 5 examples, cosmetics cause 4 examples.Two groups in age, the course of disease, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).
Diagnostic criteria: refer to that (toe) first is one-sided or bilateral nail groove near-end is rubescent, swelling, then can occur pus point, occur granulation toes after suppurating.
Therapeutic Method:
Treatment group: Chinese medicine embodiment 1 liniment spatula of the present invention is scraped about 0.3-0.5cm on gauze, then spread on affected part, immobilization with adhesive tape outward, change dressings every day once, medication 7 days.
Matched group: adopt mupirocin ointment (Mupirocin Ointment) to be applied to affected part, affected part with dressing wrapping or can cover, and changes dressings every day three times, medication 7 days.
Curative effect judging standard: cure: skin lesion disappears completely, without pain.Effective: skin lesion disappears >=and 70%, without obvious pain.Effective: 70%> skin lesion disappears >=and 30%, pain obviously alleviates.Invalid: skin lesion disappears <30% or without significant change, pain is not improved.
Therapeutic outcome: see the following form.
| Group | n | Cure | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 44 | 30 | 9 | 4 | 1 | 43(97.73％) |
| Matched group | 44 | 19 | 13 | 6 | 6 | 38(86.36％) |
Clinical observation on the therapeutic effect: 1, pain relieving: treatment group Most patients is after application liniment of the present invention, and in 1 hour, pain has obvious alleviation, the most only needs within 12 minutes, to get final product obvious alleviating pain; And matched group Most patients needs 1-2 talent can obvious alleviating pain, about needing half a day at the soonest.2, subside a swelling: treatment group Most patients, in 2-3 days, redness is eliminated or is controlled, and can control redness in the fastest 24 hours, controls in 4 days at the latest; And matched group Most patients needs could eliminate or control for 3-5 days redness, take about 2 days at the soonest, the slowest about 6-7 days.
Concrete case: Wang, male, 26 years old, sufficient big toe one-sided nail groove near-end was rubescent, swelling, then occurs pus point.Be diagnosed as paronychia.Use Chinese medicine embodiment 1 liniment of the present invention recovery from illness in 7 days, follow up a case by regular visits to and do not recur for 1 month.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. treat a paronychial Chinese medicine, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Caulis cyatheae spinulosae, Rhizoma et Radix Diphylleiae, Herba Eupatorii Heterophylli, ovum leaf Rhizoma aspidistrae elatioris, Radix Allophylli Viridis, Vanda amesiana Reichb. F, water ghost any of several broadleaf plants, Folium Paraquilegiae microphyllae, Radix Seu Caulis Rhaphidophorae Decursivae, Rhizoma Ardisiae Gigantifoliae, Radix Chloranthi Serrati, Caulis Trachelospermi, Chiba Radix Angelicae Pubescentis and Rhizoma Polygoni sinensis.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis cyatheae spinulosae 25 ~ 35 parts, Rhizoma et Radix Diphylleiae 25 ~ 40 parts, Herba Eupatorii Heterophylli 30 ~ 40 parts, ovum leaf Rhizoma aspidistrae elatioris 25 ~ 35 parts, Radix Allophylli Viridis 20 ~ 30 parts, Vanda amesiana Reichb. F 25 ~ 35 parts, water ghost any of several broadleaf plants 20 ~ 30 parts, Folium Paraquilegiae microphyllae 15 ~ 25 parts, Radix Seu Caulis Rhaphidophorae Decursivae 30 ~ 40 parts, Rhizoma Ardisiae Gigantifoliae 20 ~ 30 parts, Radix Chloranthi Serrati 5 ~ 15 parts, Caulis Trachelospermi 10 ~ 25 parts, Chiba Radix Angelicae Pubescentis 20 ~ 30 parts and Rhizoma Polygoni sinensis 5 ~ 15 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis cyatheae spinulosae 25 ~ 30 parts, Rhizoma et Radix Diphylleiae 30 ~ 35 parts, Herba Eupatorii Heterophylli 35 ~ 40 parts, ovum leaf Rhizoma aspidistrae elatioris 25 ~ 30 parts, Radix Allophylli Viridis 20 ~ 25 parts, Vanda amesiana Reichb. F 25 ~ 30 parts, water ghost any of several broadleaf plants 20 ~ 25 parts, Folium Paraquilegiae microphyllae 15 ~ 20 parts, Radix Seu Caulis Rhaphidophorae Decursivae 30 ~ 35 parts, Rhizoma Ardisiae Gigantifoliae 25 ~ 30 parts, Radix Chloranthi Serrati 5 ~ 10 parts, Caulis Trachelospermi 15 ~ 25 parts, Chiba Radix Angelicae Pubescentis 20 ~ 25 parts and Rhizoma Polygoni sinensis 5 ~ 10 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis cyatheae spinulosae 28 parts, Rhizoma et Radix Diphylleiae 32 parts, Herba Eupatorii Heterophylli 36 parts, ovum leaf Rhizoma aspidistrae elatioris 28 parts, Radix Allophylli Viridis 25 parts, Vanda amesiana Reichb. F 30 parts, water ghost any of several broadleaf plants 23 parts, Folium Paraquilegiae microphyllae 19 parts, Radix Seu Caulis Rhaphidophorae Decursivae 32 parts, Rhizoma Ardisiae Gigantifoliae 25 parts, Radix Chloranthi Serrati 7 parts, Caulis Trachelospermi 18 parts, Chiba Radix Angelicae Pubescentis 22 parts and Rhizoma Polygoni sinensis 8 parts.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis cyatheae spinulosae 26 parts, Rhizoma et Radix Diphylleiae 35 parts, Herba Eupatorii Heterophylli 38 parts, ovum leaf Rhizoma aspidistrae elatioris 25 parts, Radix Allophylli Viridis 22 parts, Vanda amesiana Reichb. F 27 parts, water ghost any of several broadleaf plants 21 parts, Folium Paraquilegiae microphyllae 16 parts, Radix Seu Caulis Rhaphidophorae Decursivae 35 parts, Rhizoma Ardisiae Gigantifoliae 28 parts, Radix Chloranthi Serrati 8 parts, Caulis Trachelospermi 20 parts, Chiba Radix Angelicae Pubescentis 20 parts and Rhizoma Polygoni sinensis 7 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is liniment, and its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;
Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds weight portion 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is membranous patch, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, powder 6.5 ~ 7.5 weight portion prepared by the first step, polyvinyl alcohol 2 ~ 3 weight portion, the abundant mix and blend of glycerol 0.5 ~ 1 weight portion, produces to without minute bubbles, leaves standstill 20 ~ 30 minutes, obtained mixing paste;
3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is liniment, and its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;
Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds weight portion 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is membranous patch, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, powder 6.5 ~ 7.5 weight portion prepared by the first step, polyvinyl alcohol 2 ~ 3 weight portion, the abundant mix and blend of glycerol 0.5 ~ 1 weight portion, produces to without minute bubbles, leaves standstill 20 ~ 30 minutes, obtained mixing paste;
3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104147370A (en) * | 2014-08-22 | 2014-11-19 | 曹松华 | Traditional Chinese medicine for treating paronychia and preparing method thereof |
| CN104721327A (en) * | 2013-12-20 | 2015-06-24 | 陕西康乐中医药养生研究院 | Traditional Chinese medicine externally applied medicine used for treating paronychia |
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| CN104721327A (en) * | 2013-12-20 | 2015-06-24 | 陕西康乐中医药养生研究院 | Traditional Chinese medicine externally applied medicine used for treating paronychia |
| CN104147370A (en) * | 2014-08-22 | 2014-11-19 | 曹松华 | Traditional Chinese medicine for treating paronychia and preparing method thereof |
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| CN106075111A (en) * | 2016-06-19 | 2016-11-09 | 王京涛 | One treats paronychial Chinese medicine preparation and preparation method thereof |
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Application publication date: 20151125 |