CN104147370A - Traditional Chinese medicine for treating paronychia and preparing method thereof - Google Patents
Traditional Chinese medicine for treating paronychia and preparing method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating paronychia and a preparing method thereof. The traditional Chinese medicine includes the raw medicinal materials: gynura bicolor, emilia sonchifolia, galium spurium, corydalis bungeana turcz, lindernia angustifolia, anemone hupehensis, herb of malay blumea, lotus corniculatus, luisiazeydahioa lindl, herb of fewleaf schnabelia, root of hairy anemone, Indian skullcap herb, geophila herbacea and radix anemones rivularis. The traditional Chinese medicine is capable of clearing heat and detoxifying, resolving blood stasis to dredge channels, and removing swelling and discharging pus, has a definite curative effect on paronychia, and has small side effects.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, relate in particular to a kind of paronychial Chinese medicine and preparation method thereof for the treatment of.
Background technology
Paronychia is many by due to infection of staphylococcus aureus, and streptococcus, Pseudomonas bacillus pyocyaneus, escherichia coli and proteus vulgaris also can be caused a disease.Primary disease is often secondary to wound, tear, bite, repair finger (toe) first after, but also have or not obvious partial trauma history person.Skin lesion is sent out in nail groove place, and cardinal symptom is local redness, suppuration, diabrosis, scorching hot, pain.
Paronychia belongs to Chinese medicine " sunken first " category.The traditional Chinese medical science thinks that this disease belongs to pyretic toxicity stagnation type, is mainly that plain body natural endowment is not resistance to, and the damp and hot poison of diseases caused by exogenous pathogenic factor is evil, and pathogenic heat harmony is poly-, retardance meridians, and pyretic toxicity can not leak, and strongly fragrantly in skin, causes primary disease.
Summary of the invention
Technical problem to be solved by this invention is, a kind of paronychial Chinese medicine and preparation method thereof for the treatment of is provided, Effect of Chinese Medicine Qing thermal detoxification of the present invention, and dissipating blood stasis dredging collateral, detumescence and apocenosis, has definite curative effect to paronychia, and side effect is little.
In order to solve the problems of the technologies described above, the invention provides a kind of paronychial Chinese medicine for the treatment of, its raw medicinal material comprises: gynura bicolor, Herba Duchesneae Indicae, Galium spurium L., Herba Violae, Lindernia angustifolia (Benth.) Wettst., Herba Anemones Hupehensis, Herba Blumeae Lacerae, Herba Galii Bungei, Herba Eriae Panneae, Herba Schnabeliae Oligophyllae, Radix Anemones Tomentosae, Herba Scutellariae indicae, come out of retirement and take up an official post tiger and Radix Anemones Rivularis.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: 20～30 parts of gynura bicolors, 15～25 parts of Herba Duchesneae Indicae, 30～40 parts of Galium spurium L.s, 15～25 parts of Herba Violaes, 10～20 parts of Lindernia angustifolia (Benth.) Wettst.s, 5～15 parts of Herba Anemones Hupehensiss, 10～20 parts of Herba Blumeae Laceraes, 5～15 parts of Herba Galii Bungei, 15～25 parts of Herba Eriae Panneae, 10～20 parts of Herba Schnabeliae Oligophyllaes, 5～15 parts of Radix Anemones Tomentosaes, 5～15 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 5～15 parts of tiger 10～20 parts and Radix Anemones Rivulariss.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: 20～25 parts of gynura bicolors, 15～20 parts of Herba Duchesneae Indicae, 30～35 parts of Galium spurium L.s, 15～20 parts of Herba Violaes, 10～15 parts of Lindernia angustifolia (Benth.) Wettst.s, 5～10 parts of Herba Anemones Hupehensiss, 10～15 parts of Herba Blumeae Laceraes, 5～10 parts of Herba Galii Bungei, 15～20 parts of Herba Eriae Panneae, 10～15 parts of Herba Schnabeliae Oligophyllaes, 5～10 parts of Radix Anemones Tomentosaes, 5～10 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 5～10 parts of tiger 10～15 parts and Radix Anemones Rivulariss.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: 22 parts of gynura bicolors, 18 parts of Herba Duchesneae Indicae, 34 parts of Galium spurium L.s, 16 parts of Herba Violaes, 11 parts of Lindernia angustifolia (Benth.) Wettst.s, 8 parts of Herba Anemones Hupehensiss, 13 parts of Herba Blumeae Laceraes, 7 parts of Herba Galii Bungei, 19 parts of Herba Eriae Panneae, 14 parts of Herba Schnabeliae Oligophyllaes, 6 parts of Radix Anemones Tomentosaes, 6 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 9 parts of tiger 12 parts and Radix Anemones Rivulariss.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: 24 parts of gynura bicolors, 16 parts of Herba Duchesneae Indicae, 31 parts of Galium spurium L.s, 19 parts of Herba Violaes, 14 parts of Lindernia angustifolia (Benth.) Wettst.s, 7 parts of Herba Anemones Hupehensiss, 11 parts of Herba Blumeae Laceraes, 6 parts of Herba Galii Bungei, 17 parts of Herba Eriae Panneae, 12 parts of Herba Schnabeliae Oligophyllaes, 8 parts of Radix Anemones Tomentosaes, 7 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 6 parts of tiger 14 parts and Radix Anemones Rivulariss.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step: described raw medicinal material is washed with water totally, pull out and dry; With pulverizer, be ground into smalls, sieve and make 90～120 object smalls;
Second step: decoct and ceaselessly stir putting into the pot that vegetable oil is housed in described ratio, its temperature is 280～330 ℃, and the time is 35～60 minutes, afterwards after filtration medicine juice;
The 3rd step: by above-mentioned medicine juice heating, its temperature is 180～220 ℃, ceaselessly stirs simultaneously, endures 2～3 hours to obtain ointment.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and the dosage form of described Chinese medicine is washing liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step: add the ethanol that the determining alcohol with respect to 3～5 times of the quality of described mixed powder is 85%～95% in the mixed powder that the first step obtains, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 5 ℃～10 ℃ standing 24～36 hours, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 40～60 minutes, obtain the mixed powder of the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
The 3rd step: add the deionized water with respect to 2～3 times of mixed powder quality in the mixed powder obtaining at second step, decoct 2～4 hours, filter, obtain medicine juice.
Beneficial effect of the present invention: Effect of Chinese Medicine Qing thermal detoxification of the present invention, dissipating blood stasis dredging collateral, detumescence and apocenosis, has definite curative effect to paronychia, and side effect is little.
The specific embodiment
The invention provides a kind of paronychial Chinese medicine for the treatment of, its raw medicinal material comprises: gynura bicolor, Herba Duchesneae Indicae, Galium spurium L., Herba Violae, Lindernia angustifolia (Benth.) Wettst., Herba Anemones Hupehensis, Herba Blumeae Lacerae, Herba Galii Bungei, Herba Eriae Panneae, Herba Schnabeliae Oligophyllae, Radix Anemones Tomentosae, Herba Scutellariae indicae, come out of retirement and take up an official post tiger and Radix Anemones Rivularis.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Gynura bicolor: sweet, pungent, cool.Cooling blood for hemostasis, clearing heat for detumescence.For hemoptysis, metrorrhagia, dysmenorrhea, vim and vigour pain, bronchitis, pelvic inflammatory disease, heatstroke, amebic dysentery; Wound hemorrhage is controlled in external, and ulcer does not close up for a long time, furuncle carbuncle, paronychia.
Herba Duchesneae Indicae: hardship, cool.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Your Majesty's respiratory tract infection, laryngopharynx swelling and pain, oral ulcer, pneumonia, acute enteritis, bacillary dysentery, urinary system infection, orchitis, mastitis, furuncle and phyma skin infection, skin eczema, osteopatia sprain.
Galium spurium L.: sweet, pungent, micro-hardship, flat.Heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, stops blooding treating stranguria.Main stranguria, hematuria, appendicitis, paronychia, traumatic injury, bones and muscles pain.
Herba Violae: hardship, cold.Return liver, spleen channel.Heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Main furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom.Chinese herbal medicine > > is commonly used in < < Shanghai: heat-clearing and toxic substances removing, externally applied toxicity removing detumescence.Control conjunctival congestion and swelling pain, hordeolum, furuncle swelling toxin, acute mastitis, enteritis, diarrhea, venom.
Lindernia angustifolia (Benth.) Wettst.: acrid in the mouth, hardship, property is flat.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Cure mainly jaundice due to damp-heat, have loose bowels, dysentery, laryngopharynx swelling and pain, traumatic injury.
Herba Anemones Hupehensis: hardship, pungent, flat.Return spleen, stomach, large intestine channel.Clearing away heat-damp and promoting diuresis, removing toxic substances parasite killing, detumescence dissipating blood stasis.Main dysentery, has loose bowels, malaria, ascariasis, furuncle carbuncle, scrofula, traumatic injury.< < Shaanxi Chinese herbal medicine > >: heat-clearing and toxic substances removing, evacuation of pus granulation promoting, detumescence dissipating blood stasis, promoting digestion and removing stagnation, preventing the attack (or recurrence) of malaria, parasite killing.Control stubborn dermatitis, tinea alba, furuncle carbuncle, innominate toxic swelling, malaria, dysentery, infantile malnutrition, dyspepsia, traumatic injury.
Herba Blumeae Lacerae: hardship, cold.Clearing away heat-fire; Removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Toothache due to stomach-fire; Zha rib; Carbuncle sore tumefacting virus.< < Yunnan Chinese herbal medicine > >: heat-clearing and toxic substances removing, antiinflammatory.Control infantile pneumonia, tonsillitis, parotitis, stomatitis, innominate toxic swelling, skin pruritus.
Herba Galii Bungei: sweet, flat.Return liver, spleen channel.Clearing away heat and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Control urinary tract infection, leucorrhea with red and white discharge, dysentery, carbuncle, traumatic injury.
Herba Eriae Panneae: hardship, cool.Return lung, heart channel.Eliminating stasis to stop pain, heat-clearing and toxic substances removing.Main lumbago and skelalgia, traumatic injury, fracture, carbuncle furuncle is swollen, burn and scald, drug intoxication.< < Simao, Yunnan Chinese herbal medicine selects > >: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, synthetism.Control traumatic injury, fracture, carbuncle furuncle is swollen, burn and scald, drug intoxication.
Herba Schnabeliae Oligophyllae: pungent, hardship, temperature.Dispelling wind and removing obstruction in the collateral, eliminating stasis to stop pain.Dispelling the wind and dampness pathogens arthralgia pain, numb limbs and tense tendons, traumatic injury, amenorrhea.
Radix Anemones Tomentosae: hardship; Temperature; Slightly poisonous.Return lung, large intestine channel.Reduce phlegm; Dissipating blood stasis; Promoting digestion and removing stagnation; Preventing the attack (or recurrence) of malaria; Removing toxic substances; Parasite killing.Main impairment caused by overstrain cough with asthma; Traumatic injury; Infantile malnutrition; Malaria; Furuncle carbuncle furuncle; Stubborn dermatitis.< < Chongqing medical herbs > >: reduce phlegm, cough-relieving, except poison.Control cough due to fluid-retention, asthma, the son of itching.< < Shaanxi Chinese herbal medicine > >: heat-clearing and toxic substances removing, evacuation of pus granulation promoting, detumescence dissipating blood stasis, promoting digestion and removing stagnation, preventing the attack (or recurrence) of malaria, parasite killing.Control various stubborn dermatitis, tinea alba, furuncle carbuncle, innominate toxic swelling, malaria, dysentery, infantile malnutrition, traumatic injury.
Herba Scutellariae indicae: acrid in the mouth, hardship, cold in nature.GUIXIN, liver, lung meridian.Heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, hemostasia and detumescence.Main carbuncle furunculosis, lung abscess, acute appendicitis, scrofula, venom, lung-heat cough with asthma, toothache, sore throat, pharyngalgia, bones and muscles pain, spits blood, and spitting of blood, has blood in stool, traumatic injury, wound hemorrhage, skin pruritus.< < Quanzhou book on Chinese herbal medicine > >: heat-clearing and toxic substances removing, Huang is moved back in detumescence, by blood removing blood stasis with potent drugs, removing pus and relieving carbuncle, cooling blood for hemostasis, throat.Cure mainly all larynx Huang, also control the high dyspnea of heat type of lung-fire and cough, spit blood, hemoptysis spitting of blood, crazy blood is had a pain, and knife injury is hemorrhage, malignant boil carbuncle, tiger, lyssodexis.
The tiger of coming out of retirement and taking up an official post: hardship, pungent, be slightly cold.Detumescence and apocenosis; Eliminating stasis to stop pain.Main swollen ulcer drug, traumatic pain, venom.(selecting from the herbal > > of < < China)
Radix Anemones Rivularis: hardship, pungent, temperature.Return lung, stomach, Liver Channel.Heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation, reducing swelling and alleviating pain.Main laryngopharynx swelling and pain, mumps, scrofula tuberculosis, swollen ulcer drug, malaria, cough, jaundice due to damp-heat, rheumatalgia, stomachache, toothache, traumatic injury.< < Qinghai-Tibet Platean medicine illustrated handbook > >: enrich blood, warm body, removing food stagnancy, dries, and more creates evacuation of pus.After curing the disease, body temperature is not enough, gonorrhea, and yellow fluid amass in joint, impetigo (external application can harness the Yellow River chickenpox or proposition joint in yellow fluid), chronic tracheitis, peripheral nerve paralysis, emetic gastric acid.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: 20～30 parts of gynura bicolors, 15～25 parts of Herba Duchesneae Indicae, 30～40 parts of Galium spurium L.s, 15～25 parts of Herba Violaes, 10～20 parts of Lindernia angustifolia (Benth.) Wettst.s, 5～15 parts of Herba Anemones Hupehensiss, 10～20 parts of Herba Blumeae Laceraes, 5～15 parts of Herba Galii Bungei, 15～25 parts of Herba Eriae Panneae, 10～20 parts of Herba Schnabeliae Oligophyllaes, 5～15 parts of Radix Anemones Tomentosaes, 5～15 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 5～15 parts of tiger 10～20 parts and Radix Anemones Rivulariss.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: 20～25 parts of gynura bicolors, 15～20 parts of Herba Duchesneae Indicae, 30～35 parts of Galium spurium L.s, 15～20 parts of Herba Violaes, 10～15 parts of Lindernia angustifolia (Benth.) Wettst.s, 5～10 parts of Herba Anemones Hupehensiss, 10～15 parts of Herba Blumeae Laceraes, 5～10 parts of Herba Galii Bungei, 15～20 parts of Herba Eriae Panneae, 10～15 parts of Herba Schnabeliae Oligophyllaes, 5～10 parts of Radix Anemones Tomentosaes, 5～10 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 5～10 parts of tiger 10～15 parts and Radix Anemones Rivulariss.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: 22 parts of gynura bicolors, 18 parts of Herba Duchesneae Indicae, 34 parts of Galium spurium L.s, 16 parts of Herba Violaes, 11 parts of Lindernia angustifolia (Benth.) Wettst.s, 8 parts of Herba Anemones Hupehensiss, 13 parts of Herba Blumeae Laceraes, 7 parts of Herba Galii Bungei, 19 parts of Herba Eriae Panneae, 14 parts of Herba Schnabeliae Oligophyllaes, 6 parts of Radix Anemones Tomentosaes, 6 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 9 parts of tiger 12 parts and Radix Anemones Rivulariss.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: 24 parts of gynura bicolors, 16 parts of Herba Duchesneae Indicae, 31 parts of Galium spurium L.s, 19 parts of Herba Violaes, 14 parts of Lindernia angustifolia (Benth.) Wettst.s, 7 parts of Herba Anemones Hupehensiss, 11 parts of Herba Blumeae Laceraes, 6 parts of Herba Galii Bungei, 17 parts of Herba Eriae Panneae, 12 parts of Herba Schnabeliae Oligophyllaes, 8 parts of Radix Anemones Tomentosaes, 7 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 6 parts of tiger 14 parts and Radix Anemones Rivulariss.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step: described raw medicinal material is washed with water totally, pull out and dry; With pulverizer, be ground into smalls, sieve and make 90～120 object smalls;
Second step: decoct and ceaselessly stir putting into the pot that vegetable oil is housed in described ratio, its temperature is 280～330 ℃, and the time is 35～60 minutes, afterwards after filtration medicine juice;
The 3rd step: by above-mentioned medicine juice heating, its temperature is 180～220 ℃, ceaselessly stirs simultaneously, endures 2～3 hours to obtain ointment.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and the dosage form of described Chinese medicine is washing liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step: add the ethanol that the determining alcohol with respect to 3～5 times of the quality of described mixed powder is 85%～95% in the mixed powder that the first step obtains, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 5 ℃～10 ℃ standing 24～36 hours, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 40～60 minutes, obtain the mixed powder of the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
The 3rd step: add the deionized water with respect to 2～3 times of mixed powder quality in the mixed powder obtaining at second step, decoct 2～4 hours, filter, obtain medicine juice.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand whereby how application technology means solve technical problem in the present invention, reach technique effect and implement according to this.
Embodiment 1 unguentum
Get gynura bicolor 220g, Herba Duchesneae Indicae 180g, Galium spurium L. 340g, Herba Violae 160g, Lindernia angustifolia (Benth.) Wettst. 110g, Herba Anemones Hupehensis 80g, Herba Blumeae Lacerae 130g, Herba Galii Bungei 70g, Herba Eriae Panneae 190g, Herba Schnabeliae Oligophyllae 140g, Radix Anemones Tomentosae 60g, Herba Scutellariae indicae 60g, brave 120g and Radix Anemones Rivularis 90g come out of retirement and take up an official post;
Preparation according to the following steps:
The first step: described raw material is washed with water totally, pull out and dry; With pulverizer, be ground into smalls, sieve and make 120 object smalls;
Second step: decoct and ceaselessly stir putting into the pot that vegetable oil is housed in described ratio, its temperature is 330 ℃, and the time is 60 minutes, afterwards after filtration medicine juice;
The 3rd step: by above-mentioned medicine juice heating, its temperature is 220 ℃, ceaselessly stirs simultaneously, endures 3 hours to obtain ointment.
Embodiment 2 washing liquids
Get gynura bicolor 240g, Herba Duchesneae Indicae 160g, Galium spurium L. 310g, Herba Violae 190g, Lindernia angustifolia (Benth.) Wettst. 140g, Herba Anemones Hupehensis 70g, Herba Blumeae Lacerae 110g, Herba Galii Bungei 60g, Herba Eriae Panneae 170g, Herba Schnabeliae Oligophyllae 120g, Radix Anemones Tomentosae 80g, Herba Scutellariae indicae 70g, brave 140g and Radix Anemones Rivularis 60g come out of retirement and take up an official post;
Preparation according to the following steps:
The first step: described raw medicinal material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 1 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step: add the ethanol that the determining alcohol with respect to 3 times of the quality of described mixed powder is 85% in the mixed powder that the first step obtains, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 10 ℃ standing 24 hours, adopt percolation with the speed of 2ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 60 minutes, obtain the mixed powder of the micron particles of 1 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, described mixed powder powder rate be 95%,
The 3rd step: add the deionized water with respect to 3 times of mixed powder quality in the mixed powder obtaining at second step, decoct 3 hours, filter, obtain medicine juice.
Toxicity test:
1, experimental technique: guinea pig back spinal column both sides are evenly coated depilatory, make approximately 40 square centimeters of unhairing scopes.Clean depilatory returns cage to observe 24 hours, is divided at random four groups, 15 every group, wherein three groups of Cavia porcelluss are coated with respectively externally used paste pure water diluent 0.3,0.5 and the 0.8ml of Chinese medicine preparation embodiment 1 of the present invention, containing crude drug 98mg, 163mg and 261mg, another group is coated with solvent 0.8ml, every twice-daily respectively, continuous one week, after experiment finishes, Cavia porcellus is put to death to the heart, liver, kidney and depilation skin are done pathological examination.
2, result: above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity activity, histopathologic examination, the administration group heart, liver, kidney and depilation skin and matched group be no significant difference more also.
Results suggest, Chinese medicine for external application of the present invention, without local irritant effect, also has no general toxicity performance.Show that Chinese medicine for external application of the present invention is used safety.
Clinical data:
Case selection: whole 102 routine cases are my Out-patient Department patient of in June, 2010～2013 year December.Patient is divided into treatment group and matched group at random, treatment group 54 people wherein, male 32 people, women 22 people, 13～66 years old age, the course of disease 4～18 days; Site of pathological change: finger 38 examples, toes 16 examples; Pathogenic factor: ingrowing nail causes 10 examples, repaiies finger (toe) first and causes 16 examples, pulls out first agnail and causes 7 examples, and dermatosis secondary infection causes 15 examples, and cosmetics cause 6 examples; Matched group 48 people, male 28 people, women 20 people; 15～65 years old age, the course of disease 5～15 days; Site of pathological change: finger 35 examples, toes 13 examples; Pathogenic factor: ingrowing nail causes 9 examples, repaiies finger (toe) first and causes 14 examples, pulls out first agnail and causes 7 examples, and dermatosis secondary infection causes 12 examples, and cosmetics cause 6 examples.Two groups at aspects such as age, the course of disease, symptom and coincident with severity degree of conditions Epidemiological Analysis there was no significant difference (p>0.05) by statistics.
Diagnostic criteria: refer to that (toe) first is one-sided or bilateral nail groove near-end is rubescent, swelling, then can occur pus point, occur granulation toes after suppurating.
Therapeutic Method:
Treatment group: Chinese medicine embodiment 1 unguentum of the present invention is scraped to about 0.2cm on gauze with spatula, then spread on affected part outward, immobilization with adhesive tape, changes dressings once every day, medication 7 days.
Matched group: adopt YUSHIZHI RUANGAO external application affected part (Bao Fatong treatment group), change dressings every day once, medication 7 days.
Curative effect judging standard: cure: skin lesion disappears completely, without pain.Effective: skin lesion disappears >=70%, without obvious pain.Effective: 70%> skin lesion disappears >=and 30%, pain obviously alleviates.Invalid: disappear <30% or without significant change, pain is not improved of skin lesion.
Therapeutic outcome: see the following form
| Group | n | Cure | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 54 | 36 | 10 | 6 | 2 | 52(96.30％) |
| Matched group | 48 | 20 | 14 | 7 | 7 | 41(85.42％) |
Concrete case: grandson, male, 36 years old, finger forefinger caused that because having a manicure the one-sided nail groove near-end of forefinger is rubescent, swelling, then occurs pus point.Be diagnosed as paronychia.Use Chinese medicine embodiment 1 unguentum of the present invention recovery from illness in 7 days, follow up a case by regular visits to not recurrence in 1 month.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. the paronychial Chinese medicine for the treatment of, is characterized in that, each raw medicinal material of described Chinese medicine comprises: gynura bicolor, Herba Duchesneae Indicae, Galium spurium L., Herba Violae, Lindernia angustifolia (Benth.) Wettst., Herba Anemones Hupehensis, Herba Blumeae Lacerae, Herba Galii Bungei, Herba Eriae Panneae, Herba Schnabeliae Oligophyllae, Radix Anemones Tomentosae, Herba Scutellariae indicae, come out of retirement and take up an official post tiger and Radix Anemones Rivularis.
2. Chinese medicine as claimed in claim 1, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 20～30 parts of gynura bicolors, 15～25 parts of Herba Duchesneae Indicae, 30～40 parts of Galium spurium L.s, 15～25 parts of Herba Violaes, 10～20 parts of Lindernia angustifolia (Benth.) Wettst.s, 5～15 parts of Herba Anemones Hupehensiss, 10～20 parts of Herba Blumeae Laceraes, 5～15 parts of Herba Galii Bungei, 15～25 parts of Herba Eriae Panneae, 10～20 parts of Herba Schnabeliae Oligophyllaes, 5～15 parts of Radix Anemones Tomentosaes, 5～15 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 5～15 parts of tiger 10～20 parts and Radix Anemones Rivulariss.
3. Chinese medicine as claimed in claim 1 or 2, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 20～25 parts of gynura bicolors, 15～20 parts of Herba Duchesneae Indicae, 30～35 parts of Galium spurium L.s, 15～20 parts of Herba Violaes, 10～15 parts of Lindernia angustifolia (Benth.) Wettst.s, 5～10 parts of Herba Anemones Hupehensiss, 10～15 parts of Herba Blumeae Laceraes, 5～10 parts of Herba Galii Bungei, 15～20 parts of Herba Eriae Panneae, 10～15 parts of Herba Schnabeliae Oligophyllaes, 5～10 parts of Radix Anemones Tomentosaes, 5～10 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 5～10 parts of tiger 10～15 parts and Radix Anemones Rivulariss.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 22 parts of gynura bicolors, 18 parts of Herba Duchesneae Indicae, 34 parts of Galium spurium L.s, 16 parts of Herba Violaes, 11 parts of Lindernia angustifolia (Benth.) Wettst.s, 8 parts of Herba Anemones Hupehensiss, 13 parts of Herba Blumeae Laceraes, 7 parts of Herba Galii Bungei, 19 parts of Herba Eriae Panneae, 14 parts of Herba Schnabeliae Oligophyllaes, 6 parts of Radix Anemones Tomentosaes, 6 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 9 parts of tiger 12 parts and Radix Anemones Rivulariss.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 24 parts of gynura bicolors, 16 parts of Herba Duchesneae Indicae, 31 parts of Galium spurium L.s, 19 parts of Herba Violaes, 14 parts of Lindernia angustifolia (Benth.) Wettst.s, 7 parts of Herba Anemones Hupehensiss, 11 parts of Herba Blumeae Laceraes, 6 parts of Herba Galii Bungei, 17 parts of Herba Eriae Panneae, 12 parts of Herba Schnabeliae Oligophyllaes, 8 parts of Radix Anemones Tomentosaes, 7 parts of Herba Scutellariae indicae, come out of retirement and take up an official post 6 parts of tiger 14 parts and Radix Anemones Rivulariss.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step: described raw material is washed with water totally, pull out and dry; With pulverizer, be ground into smalls, sieve and make 90～120 object smalls;
Second step: decoct and ceaselessly stir putting into the pot that vegetable oil is housed in described ratio, its temperature is 280～330 ℃, and the time is 35～60 minutes, afterwards after filtration medicine juice;
The 3rd step: by above-mentioned medicine juice heating, its temperature is 180～220 ℃, ceaselessly stirs simultaneously, endures 2～3 hours to obtain ointment.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is washing liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step: add the ethanol that the determining alcohol with respect to 3～5 times of the quality of described mixed powder is 85%～95% in the mixed powder that the first step obtains, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 5 ℃～10 ℃ standing 24～36 hours, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 40～60 minutes, obtain the mixed powder of the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
The 3rd step: add the deionized water with respect to 2～3 times of mixed powder quality in the mixed powder obtaining at second step, decoct 2～4 hours, filter, obtain medicine juice.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is unguentum, and its preparation method comprises the following steps:
The first step: described raw material is washed with water totally, pull out and dry; With pulverizer, be ground into smalls, sieve and make 90～120 object smalls;
Second step: decoct and ceaselessly stir putting into the pot that vegetable oil is housed in described ratio, its temperature is 280～330 ℃, and the time is 35～60 minutes, afterwards after filtration medicine juice;
The 3rd step: by above-mentioned medicine juice heating, its temperature is 180～220 ℃, ceaselessly stirs simultaneously, endures 2～3 hours to obtain ointment.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is washing liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
Second step: add the ethanol that the determining alcohol with respect to 3～5 times of the quality of described mixed powder is 85%～95% in the mixed powder that the first step obtains, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 5 ℃～10 ℃ standing 24～36 hours, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 40～60 minutes, obtain the mixed powder of the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
The 3rd step: add the deionized water with respect to 2～3 times of mixed powder quality in the mixed powder obtaining at second step, decoct 2～4 hours, filter, obtain medicine juice.
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| CN105497531A (en) * | 2014-11-28 | 2016-04-20 | 唐训芝 | Traditional Chinese medicine for treating paronychia |
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Address after: Ji'nan City, Shandong province 250033 Beiyuan Street No. 247, the second hospital of Shandong University Applicant after: Cao Songhua Address before: 250012 Qilu Hospital, Shandong University, 107 west Wenhua Road, Shandong, Ji'nan Applicant before: Cao Songhua |
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Free format text: CORRECT: ADDRESS; FROM: 250012 JINAN, SHANDONG PROVINCE TO: 250033 JINAN, SHANDONG PROVINCE Free format text: CORRECT: INVENTOR; FROM: CAO SONGHUA ZHU LEI TO: CAO SONGHUA HU YONG ZHU LEI |