CN109260355A

CN109260355A - A kind of composition and preparation method and the application for the treatment of and improvement psoriasis

Info

Publication number: CN109260355A
Application number: CN201811409361.6A
Authority: CN
Inventors: 杨爱岗; 梅丽娟; 刘菁琰; 高丽; 路萌
Original assignee: Shanghai Songhao Biotechnology Co Ltd
Current assignee: Shanghai Songhao Biotechnology Co Ltd
Priority date: 2018-11-23
Filing date: 2018-11-23
Publication date: 2019-01-25

Abstract

The invention discloses the composition and preparation method of a kind for the treatment of and improvement psoriasis and applications, the composition includes component A, component B, component C, component D, its quality proportioning are as follows: A100-300 parts of component, B150-250 parts of component, C180-220 parts of component, D20-50 parts of component, the component D includes overlay film saccharomycetes to make fermentation Product filtrate, Rumex patinetia, indigo naturalis, Herba portulacae, dandelion, Asian puccoon, cortex dictamni, hypoglaucous collett yam rhizome, kuh-seng, folium artemisiae argyi, cacumen biotae, Radix Glycyrrhizae, frutus cnidii, the fruit of summer cypress, the coptis, rheum officinale, radix scutellariae, Cortex Phellodendri, honeysuckle, the Chinese bulbul, wild chrysanthemum, oldenlandia diffusa, Common St.Paulswort Herb, the root bark of Chinese wolf-berry, safflower, glutinous rehmannia, rhizoma atractylodis, peppermint, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Caulis Spatholobi, wilsonii, paris polyphylla, paniculate swallowwort, Chinese prickly ash fruit, it can inhibit skin hair Thin vasopermeability, anti-inflammatory is by the stasis of blood, clearing heat and cooling blood, and the adverse reaction without glucocorticoid medicine, and the compliance of volunteer is relatively good, and recurrence rate is relatively low.

Description

A kind of composition and preparation method and the application for the treatment of and improvement psoriasis

Technical field

The present invention relates to technical field of traditional Chinese medicines, the composition and preparation method of specially a kind for the treatment of and improvement psoriasis with Using.

Background technique

Psoriasis be a kind of common, chronic and easy recurrent exerbation, with erythema, the scales of skin that peel off, epidermal hyper-proliferative be main The skin disease of symptom.According to statistics, onset of psoriasis rate in China's is 0.123%, and year neopathy rate is 0.1 ‰, this disease invades blueness more In the prime of life, the course of disease is longer, seriously affects the physical and mental health and quality of life of patient.It is one of the skin disease of current primary study.

Psoriasis is a kind of disease of multifactorial inheritance, is fallen ill related with major histocompatibility antigen (HLA), mainly people The exception of No. 6 chromosome (17q) HLA;In addition infection is also a major incentive of onset of psoriasis, including bacterium infection, true Bacterium infection etc..Streptococcus and staphylococcus aureus have obtained various confirmations to the pathogenic effects of psoriasis.It controls at present The Western medicine for treating psoriasis mainly has: vitamins (such as vitamin A acid), immunosuppressant (such as encircling element, tacrolimus), hormone The externally applied drugs such as class etc. Systemic administration, and tar class, steroids, vitamins, cutin cracking-off agent class.Although Western medicine is controlled in the recent period Therapeutic effect is preferable, but toxic side effect is larger, easy to recur after drug withdrawal, and late result is poor.

Traditional Chinese medicine has thousands of years medical practice experiences in China, with its therapeutic effect outstanding and side effect it is low and by China or even attention all over the world.Traditional Chinese medical theory thinks the generation of psoriasis mostly with ailment said due to cold or exposure visitor's table, and blood is not dry flourish, and skin loses Support related, wherein blood stasis is through this disease morbidity overall process, while according to Chinese medicine organic conception, man and nature category organic whole, Treat psoriasis should blood-stage treatment, the rules for the treatment of are aided with disperse blood stasis and dredge collateral based on enriching the blood to restore normal menstruation, removing pattogenic heat from the blood and toxic material from the body, therefore, in the market Need a kind of Chinese medicine that can treat psoriasis.

Summary of the invention

Technical problem solved by the invention is to provide the composition and preparation method of a kind for the treatment of and improvement psoriasis With application, to solve the problems in above-mentioned background technique.

Technical problem solved by the invention is realized using following technical scheme: a kind of group for the treatment of and improvement psoriasis It closes object and preparation method and application, the composition includes component A, component B, component C, component D, quality proportioning are as follows: component A100-300 parts, B150-250 parts of component, C180-220 parts of component, D20-50 parts of component, the component A include Purified Water, EDTA- disodium, carbomer, Sodium Hyaluronate, glycerol, butanediol, the component B include glycine betaine, niacinamide, sargassum fusifome, Triethanolamine, dipotassium glycyrrhizinate, tropolone, decoyl hydroximic acid, ethylene glycol, the component C include ferulic acid, olibanum Essential oil, zinc gluconate, PEG-40 rilanit special, the component D include overlay film saccharomycetes to make fermentation Product filtrate, Ba Tian acid Mould, indigo naturalis, Herba portulacae, dandelion, Asian puccoon, cortex dictamni, hypoglaucous collett yam rhizome, kuh-seng, folium artemisiae argyi, cacumen biotae, Radix Glycyrrhizae, frutus cnidii, the fruit of summer cypress, The coptis, rheum officinale, radix scutellariae, Cortex Phellodendri, honeysuckle, the Chinese bulbul, wild chrysanthemum, oldenlandia diffusa, siegesbeckia pubescens Makino grass, the root bark of Chinese wolf-berry, safflower, Huang, rhizoma atractylodis, peppermint, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Caulis Spatholobi, wilsonii, paris polyphylla, paniculate swallowwort, Chinese prickly ash fruit.

The component A quality proportioning are as follows: 50-150 parts of Purified Water, 0.1-0.2 parts of EDTA- disodium, carbomer 0.1-0.4 Part, 0.01-0.15 parts of Sodium Hyaluronate, 1-10 parts of glycerol, 1-6 parts of butanediol, the component B quality proportioning are as follows: glycine betaine 1-4 parts, 0.5-1.5 parts of niacinamide, 0.5-1.5 parts of sargassum fusifome, 0.1-0.4 parts of triethanolamine, 0.1-1 parts of dipotassium glycyrrhizinate, ring 0.01-0.2 parts of heptantriene phenolic ketone, 0.05-0.2 parts of decoyl hydroximic acid, 0.5-1.5 parts of ethylene glycol, the component C mass are matched Than: 0.1-0.4 parts of ferulic acid, 0.1-0.4 parts of olibanum essential oil, 0.1-0.4 parts of zinc gluconate, PEG-40 rilanit special 0.1-1 Part, the component D quality proportioning are as follows: 0.5-1.5 parts of overlay film saccharomycetes to make fermentation Product filtrate, 0.01-0.06 parts of Rumex patinetia, 0.01-0.1 parts of indigo naturalis, 0.01-0.1 parts of Herba portulacae, 0.01-0.1 parts of dandelion, 0.01-0.1 parts of Asian puccoon, cortex dictamni 0.01- 0.06 part, 0.01-0.1 parts of hypoglaucous collett yam rhizome, 0.01-0.1 parts of kuh-seng, 0.01-0.1 parts of folium artemisiae argyi, 0.01-0.06 parts of cacumen biotae, Radix Glycyrrhizae 0.01-0.1 parts, 0.01-0.1 parts of frutus cnidii, 0.01-0.06 parts of the fruit of summer cypress, 0.01-0.1 parts of the coptis, 0.01-0.1 parts of rheum officinale, 0.01-0.1 parts of radix scutellariae, 0.01-0.1 parts of Cortex Phellodendri, 0.01-0.1 parts of honeysuckle, 0.01-0.06 parts of the Chinese bulbul, wild chrysanthemum 0.01- 0.06 part, 0.01-0.1 parts of oldenlandia diffusa, 0.01-0.1 parts of siegesbeckia pubescens Makino grass, 0.01-0.1 parts of the root bark of Chinese wolf-berry, safflower 0.01- 0.1 part, 0.01-0.1 parts of glutinous rehmannia, 0.01-0.1 parts of rhizoma atractylodis, 0.01-0.1 parts of peppermint, 0.01-0.1 parts of Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis 0.01- 0.1 part, 0.01-0.1 parts of Caulis Spatholobi, 0.01-0.1 parts of wilsonii, 0.01-0.1 parts of paris polyphylla, paniculate swallowwort 0.01-0.1 Part, 0.01-0.1 parts of Chinese prickly ash fruit.

Preferably, the component A quality proportioning are as follows: 50 parts of Purified Water, 0.1 part of EDTA- disodium, 0.1 part of carbomer, thoroughly Bright 0.01 part of matter acid sodium, 1 part of glycerol, 1 part of butanediol, the component B quality proportioning are as follows: 1 part of glycine betaine, 0.5 part of niacinamide, 0.5 part of sargassum fusifome, 0.1 part of triethanolamine, 0.1 part of dipotassium glycyrrhizinate, 0.01 part of tropolone, decoyl hydroximic acid 0.05 Part, 0.5 part of ethylene glycol, the component C quality proportioning: 0.1 part of ferulic acid, 0.1 part of olibanum essential oil, 0.1 part of zinc gluconate, 0.1 part of PEG-40 rilanit special, the component D quality proportioning are as follows: 0.5 part of overlay film saccharomycetes to make fermentation Product filtrate, Ba Tian 0.01 part of garden sorrel, 0.01 part of indigo naturalis, 0.01 part of Herba portulacae, 0.01 part of dandelion, 0.01 part of Asian puccoon, 0.01 part of cortex dictamni, powder Bi 0.01 part of Collettii, 0.01 part of kuh-seng, 0.01 part of folium artemisiae argyi, 0.01 part of cacumen biotae, 0.01 part of Radix Glycyrrhizae, 0.01 part of frutus cnidii, the fruit of summer cypress 0.01 part, 0.01 part of the coptis, 0.01 part of rheum officinale, 0.01 part of radix scutellariae, 0.01 part of Cortex Phellodendri, 0.01 part of honeysuckle, 0.01 part of the Chinese bulbul, 0.01 part of wild chrysanthemum, 0.01 part of oldenlandia diffusa, siegesbeckia pubescens Makino careless 0.01 part, 0.01 part of the root bark of Chinese wolf-berry, 0.01 part of safflower, glutinous rehmannia 0.01 part, 0.01 part of rhizoma atractylodis, 0.01 part of peppermint, 0.01 part of Radix Salviae Miltiorrhizae, 0.01 part of Radix Angelicae Sinensis, 0.01 part of Caulis Spatholobi, 0.01 part of wilsonii, 0.01 part of paris polyphylla, 0.01 part of paniculate swallowwort, 0.01 part of Chinese prickly ash fruit.

Preferably, the component A quality proportioning are as follows: 150 parts of Purified Water, 0.2 part of EDTA- disodium, 0.4 part of carbomer, 0.15 part of Sodium Hyaluronate, 10 parts of glycerol, 6 parts of butanediol, the component B quality proportioning are as follows: 4 parts of glycine betaine, niacinamide 1.5 Part, 1.5 parts of sargassum fusifome, 0.4 part of triethanolamine, 1 part of dipotassium glycyrrhizinate, 0.2 part of tropolone, 0.2 part of decoyl hydroximic acid, 1.5 parts of ethylene glycol, the component C quality proportioning: 0.4 part of ferulic acid, 0.4 part of olibanum essential oil, 0.4 part of zinc gluconate, PEG- 40 1 part of rilanit specials, the component D quality proportioning are as follows: 1.5 parts of overlay film saccharomycetes to make fermentation Product filtrate, Rumex patinetia 0.06 part, 0.1 part of indigo naturalis, 0.1 part of Herba portulacae, 0.1 part of dandelion, 0.1 part of Asian puccoon, 0.06 part of cortex dictamni, 0.1 part of hypoglaucous collett yam rhizome, 0.1 part of kuh-seng, 0.1 part of folium artemisiae argyi, cacumen biotae 0.06,0.1 part of Radix Glycyrrhizae, 0.1 part of frutus cnidii, 0.06 part of the fruit of summer cypress, 0.1 part of the coptis, 0.1 part of rheum officinale, 0.1 part of radix scutellariae, 0.1 part of Cortex Phellodendri, 0.1 part of honeysuckle, 0.06 part of the Chinese bulbul, 0.06 part of wild chrysanthemum, oldenlandia Grass 0.1 part, siegesbeckia pubescens Makino grass 0.1 part, 0.1 part of the root bark of Chinese wolf-berry, 0.1 part of safflower, 0.1 part of glutinous rehmannia, 0.1 part of rhizoma atractylodis, 0.1 part of peppermint, 0.1 part of Radix Salviae Miltiorrhizae, 0.1 part of Radix Angelicae Sinensis, 0.1 part of Caulis Spatholobi, 0.1 part of wilsonii, 0.1 part of paris polyphylla, 0.1 part of paniculate swallowwort, Chinese prickly ash 0.1 part of fruit.

Preferably, the component A quality proportioning are as follows: 130 parts of Purified Water, 0.1 part of EDTA- disodium, 0.3 part of carbomer, 0.1 part of Sodium Hyaluronate, 8 parts of glycerol, 4 parts of butanediol, the component B quality proportioning are as follows: 3 parts of glycine betaine, niacinamide 1.3 Part, 1.3 parts of sargassum fusifome, 0.3 part of triethanolamine, 0.8 part of dipotassium glycyrrhizinate, 0.18 part of tropolone, decoyl hydroximic acid 0.18 part, 1.3 parts of ethylene glycol, the component C quality proportioning: 0.3 part of ferulic acid, 0.3 part of olibanum essential oil, zinc gluconate 0.3 Part, 1.3 parts of PEG-40 rilanit special, the component D quality proportioning are as follows: 1.3 parts of overlay film saccharomycetes to make fermentation Product filtrate, 0.04 part of Rumex patinetia, 0.08 part of indigo naturalis, 0.08 part of Herba portulacae, 0.08 part of dandelion, 0.08 part of Asian puccoon, 0.04 part of cortex dictamni, 0.08 part of hypoglaucous collett yam rhizome, 0.08 part of kuh-seng, 0.08 part of folium artemisiae argyi, 0.04 part of cacumen biotae, 0.08 part of Radix Glycyrrhizae, 0.08 part of frutus cnidii, summer cypress Sub 0.04 part, 0.08 part of the coptis, 0.08 part of rheum officinale, 0.08 part of radix scutellariae, 0.08 part of Cortex Phellodendri, 0.08 part of honeysuckle, the Chinese bulbul 0.04 Part, 0.04 part of wild chrysanthemum, 0.08 part of oldenlandia diffusa, siegesbeckia pubescens Makino grass 0.08 part, 0.08 part of the root bark of Chinese wolf-berry, 0.08 part of safflower, Yellow 0.08 part, 0.08 part of rhizoma atractylodis, 0.08 part of peppermint, 0.08 part of Radix Salviae Miltiorrhizae, 0.08 part of Radix Angelicae Sinensis, 0.08 part of Caulis Spatholobi, wilsonii 0.08 Part, 0.08 part of paris polyphylla, 0.08 part of paniculate swallowwort, 0.08 part of Chinese prickly ash fruit.

Preferably, the component A quality proportioning are as follows: 100 parts of Purified Water, 0.1 part of EDTA- disodium, 0.2 part of carbomer, 0.05 part of Sodium Hyaluronate, 5 parts of glycerol, 3 parts of butanediol, the component B quality proportioning are as follows: 2 parts of glycine betaine, 1 part of niacinamide, 1 part of sargassum fusifome, 0.2 part of triethanolamine, 0.5 part of dipotassium glycyrrhizinate, 0.1 part of tropolone, 0.15 part of decoyl hydroximic acid, second 1 part of glycol, the component C quality proportioning: 0.2 part of ferulic acid, 0.2 part of olibanum essential oil, 0.2 part of zinc gluconate, PEG-40 hydrogen Change 0.5 part of castor oil, the component D quality proportioning are as follows: 1 part of overlay film saccharomycetes to make fermentation Product filtrate, 0.03 part of Rumex patinetia, 0.05 part of indigo naturalis, 0.05 part of Herba portulacae, 0.05 part of dandelion, 0.05 part of Asian puccoon, 0.03 part of cortex dictamni, 0.05 part of hypoglaucous collett yam rhizome, hardship Join 0.05 part, 0.05 part of folium artemisiae argyi, 0.05 part of cacumen biotae, 0.05 part of Radix Glycyrrhizae, 0.05 part of frutus cnidii, 0.05 part of the fruit of summer cypress, the coptis 0.05 part, 0.05 part of rheum officinale, 0.05 part of radix scutellariae, 0.05 part of Cortex Phellodendri, 0.05 part of honeysuckle, 0.03 part of the Chinese bulbul, wild chrysanthemum 0.03 Part, 0.05 part of oldenlandia diffusa, siegesbeckia pubescens Makino careless 0.05 part, 0.05 part of the root bark of Chinese wolf-berry, 0.05 part of safflower, 0.05 part of glutinous rehmannia, rhizoma atractylodis 0.05 part, 0.05 part of peppermint, 0.05 part of Radix Salviae Miltiorrhizae, 0.05 part of Radix Angelicae Sinensis, 0.05 part of Caulis Spatholobi, 0.05 part of wilsonii, paris polyphylla 0.05 part, 0.05 part of paniculate swallowwort, 0.05 part of Chinese prickly ash fruit.

A kind of preparation method for the treatment of and the composition for alleviating acne, comprising the following steps:

(1), each raw material in component A is sequentially added into main cooker, opens stirring, is uniformly dispersed to no insoluble matter, begins to warm up； It is heated to 80-85 DEG C, 30 minutes is kept the temperature, then starts to cool down；

(2), when temperature is down to 60 DEG C hereinafter, successively each raw material in component B is added sequentially in the main cooker of step (1) again, It is stirred until homogeneous no insoluble matter；

(3), ferulic acid, olibanum essential oil, zinc gluconate, PEG-40 rilanit special in component C are mixed, is stirred until homogeneous It is bright, it is then slowly added into step (2) main cooker, is stirred until homogeneous；

(4), when being cooled to 35 DEG C or so, a raw material in component D successively then is added in step (3) and is mixed to stirring evenly Close object；

(5) mixture in step (4) is isolated and purified, centrifugal rotational speed is 3000 revs/min, and centrifugation time is 30 minutes, i.e., Obtain finished product.

Pharmacology analysis: the present invention is practise medicine experience of the inventor according to oneself many years, dialectical in conjunction with motherland's traditional Chinese medicine marrow Prescription and obtain, conditioning engine body equilibrium between yin and yang is acted on by the channel tropism of drug, strengthens the body resistance to consolidate the constitution, improve constitution, fundamentally, comprehensive Curative effect is played for lesion, to achieve the purpose that thoroughly to cure.

Rumex patinetia: pharmacological property root shape is bitter；Acid；It is cold；Effect cooling blood and hemostasis；It is clearing heat and detoxicating；Defaecation desinsection；Cure mainly haemorrhage； Carbuncle swells malignant boil furuncle；Skin disease；" illustrated handbook " is recorded: " being grown in Yinshan Mountains Cao Po, the place of mountain stream water flow, Marsh Wetland, leaf is thick, and shape is such as Deer ear, stem length spend Huang；Bitter, pungent, effect controls Baconic's disease, the disorder of gallbladder, nosotoxicosis."

Indigo naturalis: indigo naturalis is our monarch drug in a prescription, bitter in taste, salty, cold, returns liver, lung channel, has clearing heat and detoxicating, and blood cooling and ecchymoses removing, clearing liver is rushed down Effect of fire.It is that " purging the liver of pathogenic fire gallbladder dissipates stagnated fire that " this is through meeting source ", which records its effect,.Control weight under febrile virulent maculae and postpartum hot dysentery ".Indigo, Indigo red is the main component that indigo naturalis is included.Modern pharmacological research shows that indigo naturalis has good antibacterial anti-inflammatory, inhibits blood vessel The effects of hyperplasia, cell Proliferation.Have that researches show that keratinocytes to accelerate apoptosis by indigo red.

Herba portulacae: nature and flavor are cold in nature；Acid sweet in flavor；Channel tropism enters the heart channel of Hang-Shaoyin；Liver Channel；The spleen channel；Large intestine channel；Effect is clearing heat and detoxicating；Cool blood is stopped Blood；Cure mainly heat toxin dysentery；Heat gonorrhea；Renal shutdown；Leukorrhea with reddish discharge；Metrorrhagia and metrostaxis；Hemorrhoid blood；Sore carbuncle furuncle；Erysipelas；Scrofula；Wet tinea；It is white bald；Dysentery Disease (stool half-dried half is dilute)；Toxic-heat and blood stasis；Carbuncle swells furunculosis；Eczema；Snakebite and bugbite；Hematochezia；Metrostaxis；Modern times are mostly used for controlling Treat enteritis；Acute arthritis；Cystitis；Urethritis；Architis；Hemorrhoid hemorrhage.

Dandelion: pharmacological property is bitter；It is sweet；It is cold in nature；Channel tropism returns liver, stomach meridian；Effect is clearing heat and detoxicating；Carbuncle that disappears dissipating bind；Effect classification is clear The medicine of a warm nature；Sharp water medicine；Cure mainly acute mastitis；Pulmonary abscess；Acute appendicitis；Mumps；Boil poisonous soreness；Red eye, swell pain；Cold, fever；Cough；Abscess of throat； Stomach fire；Enteritis；Dysentery；Hepatitis；Gallbladder frightens inflammation；Urinary tract infections；Snakebite and bugbite；" its property of dandelion is refrigerant, controls one for " materia medica " cloud Cut and treat sore, large carbuncle, all diseases of red and swollen heat toxin ", " a supplement to augmented materia medica " says it, and " Detoxicating food-poisoning dissipates stagnant gas, changes heat toxin, disappears and dislikes swollen, knot Core is treated and is swollen ", modern pharmacology generally believes that dandelion has broad-spectrum antibacterial effect, to gold-coloured staphylococci, epidermis grape ball Bacterium, hemolytic streptococcus, micrococcus catarrhalis have significant inhibiting effect, part antibiotic can be replaced for clinic.

Asian puccoon: pharmacological property is bitter；It is cold；Channel tropism enters percardium；Liver Channel；Effect cool blood；Promoting blood circulation；Removing toxic substances promoting eruption；Cure mainly blood-head Poison is contained；Atropurpureus macula；Measles without adequate eruption；Sore；Eczema；Scald.

Cortex dictamni: for the dry root skin of rutaceae shaggy-fruited dittany Dictamnus dasycarpus Turcz..Spring, autumn two Season excavates root, removes silt and rough bark, strips root skin, dry.Nature and flavor: it is bitter, it trembles with fear.Returns spleen, stomach, bladder meridian.Root containing dictamine, Dictamnolactone, sitosterol, obacunonic acid, trigonelline, choline, Ash skin ketone, campesterol, skimmianine, γ-fagarine, shaggy-fruited dittany The chemical components such as bright alkali.Shennong's Herbal is recorded: main intermittent headache, jaundice, cough is inverse, leaching drip, swells and ache in woman's yin, the dead flesh of arthritis with fixed pain caused by dampness can not be bent It stretches, start-stop, row step." Bie Lu " is recorded: it is uneasy to treat four limbs, when row abdomen in it is too hot, drink water, be intended to away, calling out, pediatric epilepsy scared, married woman Postpartum remaining pain." haigoushen " is recorded: controlling all heat toxin wind, foul wind, wind sore, scabies are red rotten, and eyebrow hair takes off crisp, musculus cutaneus urgency, high fever evil It is cold；Principal solution heat Huang, wine Huang, acute febrile, paddy Huang, labor Huang etc..

Hypoglaucous collett yam rhizome: the dry rhizome of Chinese yam Dioscorea hypoglauca Palibin, taste are carried on the back for Dioscoreaceae Plant Powder Hardship, it is mild-natured, return kidney, stomach meridian.Energy dampness removing removes turbid, wind expelling stagnation removing.Compendium of Material Medica Shuos the function of Bi Collettii, and it is wet to be longer than evacuate pathogenic wind, so energy It controls and delays weak stupid numbness, loses turbid, all diseases of malignant sore category rheumatism person；Point out in " drugization justice ": its nature and flavor is thin, is longer than excreting dampness, and band is bitter Also it can fall, cure mainly wind-cold-dampness arthralgia.

Kuh-seng: pharmacological property is bitter in taste；It is cold；Channel tropism returns liver；Kidney；Large intestine；Small intestinl channel；Bladder；The heart channel of Hang-Shaoyin；Effect heat-clearing and damp-drying drug； Wind dispelling insecticide；Effect sorts out heat-clearing and damp-drying drug；Cure mainly damp-heat dysentery；Hematochezia；Jaundice；Difficult urination；Oedema；Leukorrhagia； Pruritus vulvae；Scabies；Leprosy；Pruitus；Wet poison sore；" the southern regions of the Yunnan Province book on Chinese herbal medicine ": cool blood, relieving heat toxin, scabies leprosy, impetigo poison.Treat skin Itch, blood wind tinea sore, naughty white bits, discharging fresh blood stool, hematochezia.Disappear wind, detumescence poison, acute purulent lymphadenitis.

Folium artemisiae argyi: pharmacological property acrid flavour；It is bitter；It is warm-natured；Channel tropism returns liver；Spleen；Kidney channel；Effect: warming channel for arresting bleeding；Eliminating cold to stop pain；Clearing damp It is antipruritic；Effect classification hemostatic；Clearing damp medicine；Cure mainly haematemesis；Bleeding from five sense organs or subcutaneous tissue；Painstaking blood；Hematochezia；Hematochezia；Metrorrhagia and metrostaxis；Gestation hemorrhage；Menstruation It is uncomfortable；Dysmenorrhea；Threatened abortion；Trusted subordinate's crymodynia；Diarrhea protracted dysentery；Choleraic myospasm；Leukorrhagia；Eczema；Scabies；Hemorrhoid；Large carbuncle.

Cacumen biotae: pharmacological property is bitter；It is puckery；Cold nature；Channel tropism lung；Liver；Large intestine channel；Effect cooling blood and hemostasis；Cough-relieving apophlegmatic；It dispels Rheumatism；Dissipate pyogenic infections；Effect classification blood-cooling hemostatic；Medicine for rheumatism；It cures mainly and controls hemoptysis；It spits blood；Bleeding from five sense organs or subcutaneous tissue；Hematuria；Bloody flux；Intestines wind Lower blood；Metrorrhagia and metrostaxis are more than；Coughing with a lot of sputum；Rheumatic arthralgia；Erysipelas；Mumps, scald；" collected statements on the herbal foundation ": cacumen biotae, fluid stopping blood remove wind Wet medicine.All haematemesis, bleeding from five sense organs or subcutaneous tissue collapse blood, hematochezia, and blood-head slime flux smashes stopping immediately for juice clothes in channels and collaterals person；It walks on all joint-running hemiplegia whole body Note, pain pole are not able to rotate person, and liquor drink is determined.Only thermal burn blood system and rheumatism injury of the tissues arteries and veins person, two diseases specially take charge of its use.But it is bitter in taste Cold how dry, if blood disease is that thermoae absurd passerby is available, such as the lung-dryness syndrome due to yin deficiency, because cough moves blood, person is not used.If numbness disease is that rheumatism closes stagnant person It can use, such as both liver and kidney deficiency, blood depletion marrow the vanquished uses hurriedly.

Radix Glycyrrhizae: pharmacological property is sweet；It is flat；Channel tropism returns spleen；Stomach；The heart；Lung channel；Effect invigorating middle warmer and replenishing QI；Relieving spasm to stop pain；Moistening lung stops Cough；Purging fire for removing toxin；Coordinating the drug actions of a prescription；Effect classification tonic；The lung moistening medicine；Cure mainly burnout deficiency of food；Emaciation with sallow complexion；Shortness of breath and palpitation； Abdominal pain loose stool；Four limbs contraction；Hysteria；Cough and asthma；Abscess of throat；Ulcerative carbuncle swelling and pain；Infant fetal toxin；And in drug, food Poison.

Frutus cnidii: pharmacological property nature and flavor are pungent；It is bitter；It is warm-natured；Channel tropism returns spleen；Kidney channel；Effect warming kidney and enhancing body；Removing dampness and destroying parasites；Wind-dispelling It is antipruritic；Effect classification drugs for dispelling internal cold；Cure mainly impotence in male；Scrotum is wet to itch；Woman's fertility；Morbid leucorrhoea duye；Pruritus vulvae swelling and pain；Wind Arthritis with fixed pain caused by dampness pain；Wet sore scabies.

The fruit of summer cypress: alias broom vegetable seeds；Broom；Pharmacological property nature and flavor are pungent；It is bitter；It is cold；Channel tropism returns kidney；Bladder meridian；Effect heat-clearing Dampness removing；Dispelling wind and arresting itching；Cure mainly difficulty and pain in micturition；Pruritus vulvae leukorrhagia；Rubeola；Eczema；Pruitus.It is suitble to the smoked therapy washed and wait external applications.

The coptis: pharmacological property is bitter；It is cold；The channel tropism heart；Liver；Stomach；Large intestine channel；Effect clearing heat-fire；Eliminating dampness；Removing toxic substances；Effect classification is clear The medicine of a warm nature；Heat-clearing and damp-drying drug；Cure mainly the high fever that pyreticosis heresy enters the heart channel of Hang-Shaoyin；It is irritated；Delirium or excess heat compel the hematemesis of the absurd row of blood；Damp and hot chest Ruffian；Diarrhea；Dysentery；The vexed insomnia of heart-fire hyperactivity；Gastropyretic vomiting or rapid digestion of food and polyorexia；Irascibility red eye, swell pain；And pathopyretic ulcer； Serious case of furuncle septicemia；Swelling and aching of gum；Aphthae；Ting ear；Swelling of vulva；Hemorrhoid blood；Eczema；Scald.

Rheum officinale: pharmacological property is bitter；It is cold in nature；Channel tropism returns stomach；Large intestine；Liver；The spleen channel；Effect is attacked stagnant；Clearing away damp-heat；Purging intense heat；It is cool Blood；Dissolving stasis；Removing toxic substances；Effect classification purgatives medicine；Cure mainly real heat constipation；Accumulation of heat in chest ruffian；Damp-heat dysentery；Jaundice；Stranguria syndrome；Oedema Abdomen is full；Difficult urination；Hot eyes；Abscess of throat；Aphthae；Gastropyretic vomiting；It spits blood；Hemoptysis；Bleeding from five sense organs or subcutaneous tissue；Hematochezia；Hematuria；Store blood； Menostasis；Postpartum stasis abdominal pain；Lumps in the chest and abdomen；Traumatic injury；Heat toxin large carbuncle；Erysipelas；Scald.

Radix scutellariae: pharmacological property is bitter；It is cold；Channel tropism return lung；Gallbladder；Spleen；Large intestine；Small intestinl channel；Effect clearing heat-fire；Eliminating dampness removing toxic substances；Only Blood；Miscarriage prevention；Dampness-heat in upper jiao in You Shanqing.Effect classification antipyretic；Cure mainly cough with lung heat；High fever and coma due to pyreticosis；Irascibility headache；Mesh Red swelling and pain；Jaundice with damp-heat pathogen；Dysentery；Heat gonorrhea；Hematemesis blood；Metrorrhagia and metrostaxis；Fetal movement with fever；Carbuncle swells furunculosis；To staphylococcus aureus, haemolysis The gram-negative bacterias such as gram positive bacterias and Escherichia coli, Pseudomonas aeruginosa such as property streptococcus have different degrees of inhibiting effect, Middle scutelloside etc. has inhibiting effect to active chronic inflammation, and can reduce capillary permeability, reduces releasing for Anaphylactic mediator It puts, there are significant anti-allergic effects.

Cortex Phellodendri: pharmacological property is bitter；It is cold；Channel tropism returns kidney；Bladder meridian；Effect heat-clearing and damp-drying drug；Purging fire for removing toxin；Effect classification is clear It is pyrolyzed poison；Heat-clearing and damp-drying drug；Cure mainly damp-heat dysentery, diarrhea, jaundice；Nocturnal emission, stranguria with turbid discharge, leukorrhagia；Hectic fever due to yin labor heat；And dispute Raw sore；Red eye, swell pain；Skin sore；Skin eczema.

Honeysuckle: pharmacological property is sweet；It is cold；Channel tropism return lung, village, stomach meridian；Effect has clearing heat and detoxicating；Effect classify dispersing swelling and dissipating binds it Effect；Cure mainly warm disease heating；Toxic-heat and blood stasis；Carbuncle swells furunculosis；Sore throat and multi-infection disease；" this is through meeting source " road its " removing toxic substances it is timid Purulence, rush down in have a benefit, ulcer burst after panacea "；Pharmaceutical research shows that honeysuckle has staphylococcus aureus, beta streptococcus Obvious inhibiting effect has certain inhibiting effect to acute and chronic, granulomatous inflammation, can significantly remove DPPH free radical and mistake Oxygen nitroso anion, and the generation of inhibitory activity oxygen and hydroxyl radical free radical have the anti-seedling of good wide spectrum, anti-inflammatory and anti-oxidant Effect.

The Chinese bulbul: pharmacological property bitter；It is cold in nature；Channel tropism returns stomach；Large intestine channel；Effect is clearing heat and detoxicating；It removes heat from the blood and relieve diarrhea；Removing dampness and destroying parasites； Effect classification heat-clearing drug；Cure mainly dysentery；Nosebleed epistaxis；Metrorrhagia and metrostaxis；Bleeding；Fever and chills a kind of malaria；Leukorrhagia；Pruritus vulvae；Eczema；Scrofula； Ulcerative carbuncle；Eye conjunctival congestion with ophthalmalgia.

Wild chrysanthemum: wild chrysanthemum: pharmacological property bitter；It is pungent；It is mild-natured；Channel tropism return lung；Liver Channel；Effect is clearing heat and detoxicating；Dispelling wind calming the liver；Function Effect classification antipyretic；Diaphoretic medicine；Heat-clearing and detoxifying drug；Cure mainly furunculosis；Ulcer；Erysipelas；Eczema；Dermatitis；Anemopyretic cold；Throat is swollen Bitterly；High blood pressure；" collected statements on the herbal foundation " road its " blood-breaking is soothing the liver, and solution malignant boil dissipates poison ".

Oldenlandia diffusa: effect is clearing heat and detoxicating；It is inducing diuresis and reducing edema；It cures mainly and damp and hot accumulates respiratory tract infection caused by poison；Almond Body is scorching；Pneumonia；Cholecystitis；Ecphyaditis；Carbuncle furuncle abscess and post-operative infection；Also it can be used for assistant treating cancer.

Common St.Paulswort Herb: pharmacological property is bitter in taste；It is cool in nature；Enter water；Wind tower；Channel tropism returns liver；Kidney channel；Effect Qinghuo Jiedu；Li Shui disappears It is swollen；Dispelling wind and eliminating dampness；Swelling and pain relieving；Relieving diarrhea with astringents；Cure mainly pump " (oedema), " hold together ox Kazakhstan and account for wave " (the puckery pain of urine heat, urinary tract Calculus), " he connects he and does " (headache and dizziness), " holding together Mei Lanshen " (arthralgia due to wind-cold-dampness disease, limbs joint are ached, joint stuffiness) " connects short Shandong is short, hold together to cover it is husky he " (abdominal pain diarrhea, red white diarrhea).

The root bark of Chinese wolf-berry: pharmacological property is sweet in flavor；It is cold in nature；Channel tropism return lung；Kidney channel；Effect clearind deficient heat；Purte the white；Cool blood；Effect classification is clear The medicine of a warm nature；Blood-cooling hemostatic；Cure mainly hectic fever due to yin deficiency；Hectic fever due to yin night sweat；Infantile malnutrition generates heat；Dyspnea and cough due to lung-heat；It spits blood；Bleeding from five sense organs or subcutaneous tissue；Hematuria；Disappear Yearningly.

Safflower: pharmacological property acrid flavour；Warm-natured channel tropism return heart；Tripe warp；Effect promoting blood circulation can be through；Stasis-dispelling and pain-killing；Effect classification blood-activating drug； Anodyne；Cure mainly menostasis；Dysmenorrhea；Postpartum stasis abdominal pain；Born of the same parents' numbness Xin Tong lumps in the chest and abdomen；Traumatic injury；Arthralgia；Middle windage yaw Complete；Macula.

Glutinous rehmannia: effect nourishing kidney-yin；Kidney-replenishing；Dissipating phlegm for resuscitation；Cure mainly coronary heart disease；Cerebral thrombosis；Cerebrovascular accident；Apoplexy；It is general Send out nerve dermatitis；Disease of old people.

Rhizoma atractylodis: pharmacological property nature and flavor are pungent；It is bitter；It is warm-natured；Channel tropism returns spleen；Stomach；Liver Channel；Effect is drying damp and strengthening spleen；Wind-damp dispelling；Improving eyesight；Function Effect classification clearing damp medicine；Drugs strengthening spleen；Diaphoretic medicine；Cure mainly the spleen and stomach being stranded by dampness；Burnout；Born of the same parents' ruffian abdominal distension；Loss of appetite；Vomiting and having loose bowel； Phlegm retention；It is wet swollen；Exterior syndrome folder is wet；Head body weight pain；Bi Zheng warm nature；Podomere, which is ached, to be weighed；Impotence folds in a garment；Yctalopia.

Peppermint: pharmacological property nature and flavor are pungent；Channel tropism return lung cool in nature；Liver Channel；Effect dissipating wind-heat；Refresh oneself；Throat；Promoting eruption；Relieve stagnation； Effect classification diaphoretic medicine；Anodyne；Cure mainly syndrome of superficies attacked by wind-heat；Headache and hot eyes；Abscess of throat；Measles without adequate eruption；Fall into rash itch；The liver depression side of body Bitterly.

Radix Salviae Miltiorrhizae: pharmacological property nature and flavor are light；Slight bitter；It is cool in nature；Effect nourishing disney and strengthening bone；Promoting blood circulation for regulating menstruation；Cooling blood and hemostasis；Effect classification kidney tonifying Bone strengthening medicine；Blood-activating and menstruation-regulating medicinal；Blood-cooling hemostatic；Cure mainly lumbago due to the kidney deficiency；Rheumatalgia；It is dizzy；Irregular menstruation；Dysmenorrhea；Menostasis；It collapses Leakage；Hematochezia；It spits blood；Bleeding from five sense organs or subcutaneous tissue；Bruise stasis caused pain；Knife wound bleeding.

Radix Angelicae Sinensis: pharmacological property nature and flavor are sweet；It is pungent；It is bitter；It is warm-natured；Channel tropism returns liver；The heart；The spleen channel；Effect is enriched blood；Promoting blood circulation；Menstruction regulating and pain relieving；Profit Dry laxation；Effect classification antianaemics；Emmenagogue；Anodyne；Cure mainly all cards of the deficiency of blood；Irregular menstruation；Menostasis；Dysmenorrhea；Disorder lump in the abdomen knot is poly-； Metrorrhagia and metrostaxis；Asthenia cold abdominalgia；Flaccidity syndrome and arthralgia syndrome；Numbness；Intestines are dry and shit is difficult；Weight after dysentery with bloody stool；Ulcer sores；Injury from falling down.

Caulis Spatholobi: pharmacological property is bitter in taste；Micro-sweet；It is warm-natured；Channel tropism return heart；The spleen channel；Effect is activated blood and relaxed tendons；Nourishing blood for regulating menstruation；Function Effect classification blood-activating drug；Nourishing blood for regulating menstruation；It cures mainly numb in every limb；Quadriplegia；Rheumatic arthralgia；Women has through uncomfortable；Dysmenorrhea；Amenorrhoea.

Wilsonii: pharmacological property nature and flavor slight bitter；It is puckery；Effect replenishes qi to invigorate the spleen；It tonifies the kidney to relieve mental strain；Cure mainly the insufficiency of both the spleen and the kindey；Asthenia； Loss of appetite；Soreness of waist and knee joint；Insomnia and dreamful sleep.

Paris polyphylla: mild toxicity, pharmacological property is bitter, cold, enters Liver Channel, there is the function of clearing heat and detoxicating cool liver arresting convulsion, is suitable for a variety of heat Carbuncle ulcer, abscess of throat, mumps, venomous snake bite, frightened epilepsy, unconsciousness due to high fever etc.." paris polyphylla be (paris polyphylla for " collected statements on the herbal foundation " speech Rhizome), cooling blood, expelling wind solves the medicine of carbuncle poison also ".Pharmacological research shows that this product is a variety of to enteric bacilli, pyococcus etc. thin The antibacterial action of bacterium, infected by influenza have inhibiting effect.

Paniculate swallowwort: pharmacological property nature and flavor；Temperature；Acrid flavour；It is toxic；Effect sedation-analgesia；Clearing damp removing toxic substances；It cures mainly and is closed for rheumatic Section pain；Headache；Toothache；Traumatic injury；It is dizzy；Skin eczema；Snakebite and bugbite.

Chinese prickly ash: pharmacological property is pungent；Temperature；It is slightly poisonous；Channel tropism returns stomach meridian；Effect warm in pain；Desinsection is antipruritic；Effect classification Drugs for dispelling internal cold；Heat-clearing and damp-drying drug；Cure mainly deficiency-cold in spleen and stomach；Coldness and pain in the epigastrium；Vomiting；Diarrhea；Roundworm abdominal pain；Eczema；Pruitus；Yin Itch；Saprodontia pain.

The present invention meets Chinese medical discrimination theory in Chinese medicine selection and compatibility, and therapeutic effect is significant, and has no toxic side effect, Complementary purpose in drug matching is reached.

Overlay film saccharomycetes to make fermentation Product filtrate: the filtered fluid after being derived from the fermentation of Saccharomycopsis yeast, composition Substance includes amino acid, vitamin, minerals and carbohydrate lymphatic temperament, has and inhibits free radical, improves the effect of skin quality, can It inhibits tyrosinase activity, to reach inhibition melanin, reaches whitening, long-acting moisturizing and accelerated ageing corneocyte more The effect newly regenerated, and there is good safety and stability.

Sargassum fusifome extract: sargassum fusifome extract is mainly polysaccharide component, including algal polysaccharide sulfate (Fucoidan FCD), alginic acid (Alginic acid) and laminaran (Laminam) etc., studies have shown that Hijiki polysaccharide With antitumor, immune, reducing blood lipid blood glucose, anti-oxidant, anticoagulation, enhancing development, antiviral isoreactivity, as outer are adjusted It applies some make up, Hijiki polysaccharide also has moisturizing, whitening and anti-aging and other effects.

Dipotassium glycyrrhizinate: dipotassium glycyrrhizinate is used as skin conditioning agent, predominantly the Radix Glycyrrhizae of Radix Glycyrrhizae root and stem Glucin (glycyrrhizic acid) ingredient is suitble to anaphylaxis skin, anti-irritant and oil-control, moves back red and swollen antiphlogistic healing effect.Skin can effectively be prevented Sensitivity inflammation phenomenon when stimulated.

Olibanum essential oil: the extraction of olibanum essential oil has a variety of medical values from olibanum resin, for skin, has anti-ageing Change, restore elasticity of skin, tighten pore, improve drying, inflammation, sensitive skin and other effects, have alleviation to infant eczema and controls The effect for the treatment of.

Zinc gluconate: zinc gluconate makees skin conditioning agent use in cosmetics, while also playing the role of oil-control.Zinc preparation It can play the role of maintaining epithelial tissue and mucous membrane completely in cosmetics, hence for host defense against bacterial infection, promote wound Healing and acne etc. have certain therapeutic effect.

Ferulic acid: ferulic acid is naturally occurring antioxidant.The ingredient has anti-oxidant, anti-inflammatory, analgesic and anti-purple UV radiation and other effects.It is the draft organic acid refined from Radix Angelicae Sinensis and asafoetide grass, can be promoted between cell and cell Consolidation skin and convergence pore are played the role of in the growth of polysaccharide body binding, and relaxation and Aging skin is suitble to use.Asafoetide Acid has the antioxidant of wide spectrum；Ferulic acid there are also skin-active, brighten it is anti-inflammatory, inhibit allergy effect.

It is compared to open technology, there are following advantages by the present invention:

(1) composition passes through overlay film saccharomycetes to make fermentation Product filtrate and and the traditional Chinese medicine ingredients knot with heat-clearing and damp-drying drug in the present invention It closes, the skin lesion part of face can be uniformly applied to, to fully absorb drug, make local vasoconstriction, hyperemia is reduced, scorching Disease reaction mitigates, and alleviates the symptom of psoriasis.

(2) composition can inhibit capillary of skin permeability in the present invention, and anti-inflammatory is by the stasis of blood, clearing heat and cooling blood, and sugar-free skin The adverse reaction of matter hormonal medicaments, therapeutic effect is obvious, and recurrence rate is relatively low.

Specific embodiment

In order to make, technological means of the invention, creation characteristic, workflow, application method reach purpose and effect is easy to bright White understanding, below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described, Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all Belong to the scope of protection of the invention.

Embodiment 1

The composition and preparation method and application, the composition of a kind for the treatment of and improvement psoriasis include component A, component B, component C, component D, quality proportioning are as follows: A100 parts of component, B150 parts of component, C180 parts of component, D20 parts of component, the component A matter Amount proportion are as follows: 50 parts of Purified Water, 0.1 part of EDTA- disodium, 0.1 part of carbomer, 0.01 part of Sodium Hyaluronate, 1 part of glycerol, fourth two 1 part of alcohol, the component B quality proportioning are as follows: 1 part of glycine betaine, 0.5 part of niacinamide, 0.5 part of sargassum fusifome, 0.1 part of triethanolamine, 0.1 part of dipotassium glycyrrhizinate, 0.01 part of tropolone, 0.05 part of decoyl hydroximic acid, 0.5 part of ethylene glycol, the component C matter Amount proportion: 0.1 part of ferulic acid, 0.1 part of olibanum essential oil, 0.1 part of zinc gluconate, 0.1 part of PEG-40 rilanit special, it is described Component D quality proportioning are as follows: 0.5 part of overlay film saccharomycetes to make fermentation Product filtrate, 0.01 part of Rumex patinetia, 0.01 part of indigo naturalis, Herba portulacae 0.01 part, 0.01 part of dandelion, 0.01 part of Asian puccoon, 0.01 part of cortex dictamni, 0.01 part of hypoglaucous collett yam rhizome, 0.01 part of kuh-seng, folium artemisiae argyi 0.01 Part, 0.01 part of cacumen biotae, 0.01 part of Radix Glycyrrhizae, 0.01 part of frutus cnidii, 0.01 part of the fruit of summer cypress, 0.01 part of the coptis, 0.01 part of rheum officinale, Huang 0.01 part of a kind of reed mentioned in ancient books, 0.01 part of Cortex Phellodendri, 0.01 part of honeysuckle, 0.01 part of the Chinese bulbul, 0.01 part of wild chrysanthemum, 0.01 part of oldenlandia diffusa, 0.01 part of Common St.Paulswort Herb, 0.01 part of the root bark of Chinese wolf-berry, 0.01 part of safflower, 0.01 part of glutinous rehmannia, 0.01 part of rhizoma atractylodis, 0.01 part of peppermint, Radix Salviae Miltiorrhizae 0.01 part, 0.01 part of Radix Angelicae Sinensis, 0.01 part of Caulis Spatholobi, 0.01 part of wilsonii, 0.01 part of paris polyphylla, 0.01 part of paniculate swallowwort, flower 0.01 part of green pepper fruit.

Embodiment 2

The composition and preparation method and application, the composition of a kind for the treatment of and improvement psoriasis include component A, component B, component C, component D, quality proportioning are as follows: A300 parts of component, B250 parts of component, C220 parts of component, D50 parts of component, the component A matter Amount proportion are as follows: 150 parts of Purified Water, 0.2 part of EDTA- disodium, 0.4 part of carbomer, 0.15 part of Sodium Hyaluronate, 10 parts of glycerol, fourth 6 parts of glycol, the component B quality proportioning are as follows: 4 parts of glycine betaine, 1.5 parts of niacinamide, 1.5 parts of sargassum fusifome, triethanolamine 0.4 Part, 1 part of dipotassium glycyrrhizinate, 0.2 part of tropolone, 0.2 part of decoyl hydroximic acid, 1.5 parts of ethylene glycol, the component C matter Amount proportion: 0.4 part of ferulic acid, 0.4 part of olibanum essential oil, 0.4 part of zinc gluconate, 1 part of PEG-40 rilanit special, the group Divide D quality proportioning are as follows: 1.5 parts of overlay film saccharomycetes to make fermentation Product filtrate, 0.06 part of Rumex patinetia, 0.1 part of indigo naturalis, Herba portulacae 0.1 Part, 0.1 part of dandelion, 0.1 part of Asian puccoon, 0.06 part of cortex dictamni, 0.1 part of hypoglaucous collett yam rhizome, 0.1 part of kuh-seng, 0.1 part of folium artemisiae argyi, cacumen biotae 0.06,0.1 part of Radix Glycyrrhizae, 0.1 part of frutus cnidii, 0.06 part of the fruit of summer cypress, 0.1 part of the coptis, 0.1 part of rheum officinale, 0.1 part of radix scutellariae, Cortex Phellodendri 0.1 Part, 0.1 part of honeysuckle, 0.06 part of the Chinese bulbul, 0.06 part of wild chrysanthemum, 0.1 0.1 part of Fen, Common St.Paulswort Herb of oldenlandia diffusa, the root bark of Chinese wolf-berry 0.1 part, 0.1 part of safflower, 0.1 part of glutinous rehmannia, 0.1 part of rhizoma atractylodis, 0.1 part of peppermint, 0.1 part of Radix Salviae Miltiorrhizae, 0.1 part of Radix Angelicae Sinensis, Caulis Spatholobi 0.1 Part, 0.1 part of wilsonii, 0.1 part of paris polyphylla, 0.1 part of paniculate swallowwort, 0.1 part of Chinese prickly ash fruit.

Embodiment 3

The composition and preparation method and application, the composition of a kind for the treatment of and improvement psoriasis include component A, component B, component C, component D, quality proportioning are as follows: A280 parts of component, B230 parts of component, C200 parts of component, D40 parts of component, the component A matter Amount proportion are as follows: 130 parts of Purified Water, 0.1 part of EDTA- disodium, 0.3 part of carbomer, 0.1 part of Sodium Hyaluronate, 8 parts of glycerol, fourth two 4 parts of alcohol, the component B quality proportioning are as follows: 3 parts of glycine betaine, 1.3 parts of niacinamide, 1.3 parts of sargassum fusifome, 0.3 part of triethanolamine, 0.8 part of dipotassium glycyrrhizinate, 0.18 part of tropolone, 0.18 part of decoyl hydroximic acid, 1.3 parts of ethylene glycol, the component C matter Amount proportion: 0.3 part of ferulic acid, 0.3 part of olibanum essential oil, 0.3 part of zinc gluconate, 1.3 parts of PEG-40 rilanit special, it is described Component D quality proportioning are as follows: 1.3 parts of overlay film saccharomycetes to make fermentation Product filtrate, 0.04 part of Rumex patinetia, 0.08 part of indigo naturalis, Herba portulacae 0.08 part, 0.08 part of dandelion, 0.08 part of Asian puccoon, 0.04 part of cortex dictamni, 0.08 part of hypoglaucous collett yam rhizome, 0.08 part of kuh-seng, folium artemisiae argyi 0.08 Part, 0.04 part of cacumen biotae, 0.08 part of Radix Glycyrrhizae, 0.08 part of frutus cnidii, 0.04 part of the fruit of summer cypress, 0.08 part of the coptis, 0.08 part of rheum officinale, Huang 0.08 part of a kind of reed mentioned in ancient books, 0.08 part of Cortex Phellodendri, 0.08 part of honeysuckle, 0.04 part of the Chinese bulbul, 0.04 part of wild chrysanthemum, 0.08 part of oldenlandia diffusa, 0.08 part of Common St.Paulswort Herb, 0.08 part of the root bark of Chinese wolf-berry, 0.08 part of safflower, 0.08 part of glutinous rehmannia, 0.08 part of rhizoma atractylodis, 0.08 part of peppermint, Radix Salviae Miltiorrhizae 0.08 part, 0.08 part of Radix Angelicae Sinensis, 0.08 part of Caulis Spatholobi, 0.08 part of wilsonii, 0.08 part of paris polyphylla, 0.08 part of paniculate swallowwort, flower 0.08 part of green pepper fruit.

Embodiment 4

The composition and preparation method and application, the composition of a kind for the treatment of and improvement psoriasis include component A, component B, component C, component D, quality proportioning are as follows: A200 parts of component, B200 parts of component, C200 parts of component, D35 parts of component, the component A matter Amount proportion are as follows: 100 parts of Purified Water, 0.1 part of EDTA- disodium, 0.2 part of carbomer, 0.05 part of Sodium Hyaluronate, 5 parts of glycerol, fourth two 3 parts of alcohol, the component B quality proportioning are as follows: 2 parts of glycine betaine, 1 part of niacinamide, 1 part of sargassum fusifome, 0.2 part of triethanolamine, Radix Glycyrrhizae 0.5 part of sour dipotassium, 0.1 part of tropolone, 0.15 part of decoyl hydroximic acid, 1 part of ethylene glycol, the component C quality proportioning: 0.2 part of ferulic acid, 0.2 part of olibanum essential oil, 0.2 part of zinc gluconate, 0.5 part of PEG-40 rilanit special, the component D matter Amount proportion are as follows: 1 part of overlay film saccharomycetes to make fermentation Product filtrate, 0.03 part of Rumex patinetia, 0.05 part of indigo naturalis, 0.05 part of Herba portulacae, Pu 0.05 part of public English, 0.05 part of Asian puccoon, 0.03 part of cortex dictamni, 0.05 part of hypoglaucous collett yam rhizome, 0.05 part of kuh-seng, 0.05 part of folium artemisiae argyi, cacumen biotae 0.05 part, 0.05 part of Radix Glycyrrhizae, 0.05 part of frutus cnidii, 0.05 part of the fruit of summer cypress, 0.05 part of the coptis, 0.05 part of rheum officinale, 0.05 part of radix scutellariae, 0.05 part of Cortex Phellodendri, 0.05 part of honeysuckle, 0.03 part of the Chinese bulbul, 0.03 part of wild chrysanthemum, 0.05 Fen, Common St.Paulswort Herb 0.05 of oldenlandia diffusa Part, 0.05 part of the root bark of Chinese wolf-berry, 0.05 part of safflower, 0.05 part of glutinous rehmannia, 0.05 part of rhizoma atractylodis, 0.05 part of peppermint, 0.05 part of Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis 0.05 part, 0.05 part of Caulis Spatholobi, 0.05 part of wilsonii, 0.05 part of paris polyphylla, 0.05 part of paniculate swallowwort, 0.05 part of Chinese prickly ash fruit.

Embodiment 5

The composition and preparation method and application, the composition of a kind for the treatment of and improvement psoriasis include component A, component B, component C, quality proportioning are as follows: A200 parts of component, B200 parts of component, C200 parts of component, the component A quality proportioning are as follows: Purified Water 100 parts, 0.1 part of EDTA- disodium, 0.2 part of carbomer, 0.05 part of Sodium Hyaluronate, 5 parts of glycerol, 3 parts of butanediol, the group Divide B quality proportioning are as follows: 2 parts of glycine betaine, 1 part of niacinamide, 1 part of sargassum fusifome, 0.2 part of triethanolamine, 0.5 part of dipotassium glycyrrhizinate, ring 0.1 part of heptantriene phenolic ketone, 0.15 part of decoyl hydroximic acid, 1 part of ethylene glycol, the component C quality proportioning: 0.2 part of ferulic acid, cream 0.2 part of essential oil, 0.2 part of zinc gluconate, 0.5 part of PEG-40 rilanit special.

(4) mixture in step (4) is isolated and purified, centrifugal rotational speed is 3000 revs/min, and centrifugation time is 30 minutes, i.e., Obtain finished product.

Clinical application

The judgment criteria of psoriasis:

1. having typical clinical manifestation, it is dry to be covered with multilayer based on papule, maculopapule and the red patch that differs in size for skin lesion The dry silvery white scales of skin that peel off strikes off the visible one layer of bright film of the scales of skin that peel off, can there is dotted bleeding under film, and substrate infiltration carries out Phase can have isomorphic effect.

2. skin lesion form can be divided into the multiple types such as a drop-wise, coin shape, patch shape, map shape, mixing shape.

3. subjective symptoms, can be with different degrees of itch.

4. predilection site is scalp, four limbs stretch side, common with elbow joint face, normal general hair whole body.It sends out in scalp person, hair is in Pencil;It sends out and (refers to, toe) person in deck, can there is pitting, thickened in thimble shape or deck out-of-flatness, flavescence.

Psoriasis staging scale:

1. the phase of progress: morbidity is anxious, and new skin lesion is more and constantly has new skin lesion to occur, and old rash constantly expands, and inflammation is obvious, can be with scabies Itch, common isomorphic effect.

2. resting stage (stationary phase): stable disease temporarily ceases development, and old rash also loses recession, and inflammation mitigates, without new hair Skin lesion.

3. paracmasis (catagen): skin lesion is thinning, and color turns light, and the scales of skin that peel off significantly reduces, until skin lesion is subsided, there are light brown Color pigmentation spots or pale depigmentation spot.

The criterion of therapeutical effect that psoriasis determines

The therapeutic evaluation of psoriasis is scored according to PASI point system, compares and carry out clinical efficacy judgement before and after treatment；PASI is commented It defends oneself bright: human body is divided into neck, upper limb, trunk, four part of lower limb, first calculate skin lesion Line Integral, then calculate separately each section Four part score of whole body is finally added, as by the scales of skin that peel off (D), infiltration (I) and erythema (E) severity point multiplied by respective coefficient PASI total score；Score value 0-72 points

The skin being grievously injured degree standards of grading table is shown in Table one

Serial number	Symptom	The scales of skin that peel off (D)	It infiltrates (I)	Erythema (E)	Skin lesion area (%)
						0	Nothing	Surface is visible without the scales of skin that peel off	Skin lesion is concordant with normal skin	It is visible without erythema	0
1	Slightly	The scales of skin that peel off is covered on the skin lesion surface of part based on the subtle scales of skin that peel off	Skin lesion is slightly above normal skin surface	In pale red	< 10
						2	Moderate	Most of skin lesion surfaces are complete or are not exclusively covered with the scales of skin that peel off, and the scales of skin that peel off is in the form of sheets	In isocratic protuberance, the edge of patch is round or slope shape	It is red	10-29
3	Severe	Almost all skin lesion surface is covered with the scales of skin that peel off, and the thicker scales of skin that peel off is in layer	Skin lesion is plump, and protuberance is obvious	Peony	30-49
						4	Pole severe	Whole skin lesion surfaces are covered with the scales of skin that peel off, and it is in layer that the scales of skin that peel off is very thick	Skin lesion height thickens, and swells extremely obvious	It is red profound	50-69

Clinical test

Object on probation: choosing 80 people of volunteer for suffering from psoriasis altogether, the age between 20-65 year old, 40 people of male, 40 people of female, year Male 15 people of the age between 20-35 years old, 15 people of women；Age between 36-50 years old, 15 people of male, 15 people of women；Age 10 people of male between 51-65 years old, 10 people of women；The above number is divided into five groups, is first group, second group, third respectively Group, the 4th and the 5th group, every group of 16 people.

Practical approach: first group of Chinese medicine composition using embodiment 1 in the present invention；Second group in the present invention using implementing The Chinese medicine composition of example 2；Third group is using the Chinese medicine composition of embodiment 3 in the present invention, and the 4th group in the present invention using implementing The Chinese medicine composition of example 4；The 5th group of composition using embodiment 5 in the present invention, every group each affected part of smearing is primary sooner or later daily, And a few minutes are gently rubbed, successively use 4 weeks.

Judgment criteria: (1) therapeutic index (skin lesion improvement rate)=(preceding PASI is controlled to integrate-control rear PASI integral)/control preceding PASI Integral * 100%；(2) it fully recovers: therapeutic index >=95%;Skin lesion is subsided completely, only stays a small number of inactivity skin lesions or pigment alteration； (3) effective: 95% > therapeutic index >=60%;Skin lesion has the recession of detail, there is the improvement of detail in symptom；(4) effectively: 60% > therapeutic index >=30%;It makes moderate progress in symptom；(5) invalid: 30% > therapeutic index, symptom are unchanged；(5) total effective rate= Cure rate+obvious effective rate+effective percentage.

Test result: two are shown in Table

Two test result of table

Group	Number of cases	Recovery from illness	It is effective	Effectively	In vain	Total effective rate
							First group	16	1	12	2	1	93.8%
Second group	16	2	14	2	0	100%
							Third group	16	1	12	3	0	100%
4th group	16	0	8	6	2	87.5%
							5th group	16	0	1	2	13	18.8%

From the point of view of test result, the present invention provides a kind of compositions for treating psoriasis to 20 to 65 years old afflicted with psoriasis Patient has significant treatment and improvement, compares with the embodiment 5 of Chinese prescription and overlay film yeast tunning filtrate is not added, Psoriasis sore can effectively be treated and be improved to the inventive composition, and 87.5% or more, mechanism study is shown total effective rate, the production Product can inhibit capillary of skin permeability, anti-inflammatory by the stasis of blood, clearing heat and cooling blood, and the adverse reaction without glucocorticoid medicine, and And the compliance of volunteer is relatively good, recurrence rate is relatively low, can be used as treatment and improves the externally applied product of psoriasis.

The above shows and describes the basic principle, main features and advantages of the invention.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes Change and improvement all fall within the protetion scope of the claimed invention.Claimed range of the invention by appended claims and Its equivalent thereof.

Claims

1. the composition and preparation method and application, the composition of a kind for the treatment of and improvement psoriasis include component A, component B, group Divide C, component D, it is characterised in that: its quality proportioning are as follows: A100-300 parts of component, B150-250 parts of component, component C180-220 Part, D20-50 parts of component, the component A includes Purified Water, EDTA- disodium, carbomer, Sodium Hyaluronate, glycerol, fourth two Alcohol, the component B include glycine betaine, niacinamide, sargassum fusifome, triethanolamine, dipotassium glycyrrhizinate, tropolone, decoyl Hydroximic acid, ethylene glycol, the component C include ferulic acid, olibanum essential oil, zinc gluconate, PEG-40 rilanit special, described Component D include overlay film saccharomycetes to make fermentation Product filtrate, Rumex patinetia, indigo naturalis, Herba portulacae, dandelion, Asian puccoon, cortex dictamni, powder Bi Collettii, kuh-seng, folium artemisiae argyi, cacumen biotae, Radix Glycyrrhizae, frutus cnidii, the fruit of summer cypress, the coptis, rheum officinale, radix scutellariae, Cortex Phellodendri, honeysuckle, the Chinese bulbul, open country Chrysanthemum, oldenlandia diffusa, Common St.Paulswort Herb, the root bark of Chinese wolf-berry, safflower, glutinous rehmannia, rhizoma atractylodis, peppermint, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Caulis Spatholobi, wilsonii, seven Leaf a flower, paniculate swallowwort, Chinese prickly ash fruit.

2. the composition and preparation method and application, feature of a kind for the treatment of as described in claim 1 and improvement psoriasis exist In the component A quality proportioning are as follows: 50-150 parts of Purified Water, 0.1-0.2 parts of EDTA- disodium, 0.1-0.4 parts of carbomer, thoroughly 0.01-0.15 parts of bright matter acid sodium, 1-10 parts of glycerol, 1-6 parts of butanediol, the component B quality proportioning are as follows: 1-4 parts of glycine betaine, 0.5-1.5 parts of niacinamide, 0.5-1.5 parts of sargassum fusifome, 0.1-0.4 parts of triethanolamine, 0.1-1 parts of dipotassium glycyrrhizinate, cycloheptatriene 0.01-0.2 parts of phenolic ketone, 0.05-0.2 parts of decoyl hydroximic acid, 0.5-1.5 parts of ethylene glycol, the component C quality proportioning: asafoetide 0.1-0.4 parts sour, 0.1-0.4 parts of olibanum essential oil, 0.1-0.4 parts of zinc gluconate, 0.1-1 parts of PEG-40 rilanit special, it is described Component D quality proportioning are as follows: 0.5-1.5 parts of overlay film saccharomycetes to make fermentation Product filtrate, 0.01-0.06 parts of Rumex patinetia, indigo naturalis 0.01-0.1 parts, 0.01-0.1 parts of Herba portulacae, 0.01-0.1 parts of dandelion, 0.01-0.1 parts of Asian puccoon, cortex dictamni 0.01-0.06 Part, 0.01-0.1 parts of hypoglaucous collett yam rhizome, 0.01-0.1 parts of kuh-seng, 0.01-0.1 parts of folium artemisiae argyi, 0.01-0.06 parts of cacumen biotae, Radix Glycyrrhizae 0.01- 0.1 part, 0.01-0.1 parts of frutus cnidii, 0.01-0.06 parts of the fruit of summer cypress, 0.01-0.1 parts of the coptis, 0.01-0.1 parts of rheum officinale, radix scutellariae 0.01-0.1 parts, 0.01-0.1 parts of Cortex Phellodendri, 0.01-0.1 parts of honeysuckle, 0.01-0.06 parts of the Chinese bulbul, wild chrysanthemum 0.01-0.06 Part, 0.01-0.1 parts of oldenlandia diffusa 0.01-0.1 Fen, Common St.Paulswort Herb, 0.01-0.1 parts of the root bark of Chinese wolf-berry, 0.01-0.1 parts of safflower, glutinous rehmannia 0.01-0.1 parts, 0.01-0.1 parts of rhizoma atractylodis, 0.01-0.1 parts of peppermint, 0.01-0.1 parts of Radix Salviae Miltiorrhizae, 0.01-0.1 parts of Radix Angelicae Sinensis, Caulis Spatholobi 0.01-0.1 parts, 0.01-0.1 parts of wilsonii, 0.01-0.1 parts of paris polyphylla, 0.01-0.1 parts of paniculate swallowwort, Chinese prickly ash fruit 0.01- 0.1 part.

3. the composition and preparation method and application, feature of a kind for the treatment of as claimed in claim 2 and improvement psoriasis exist In: the component A quality proportioning are as follows: 50 parts of Purified Water, 0.1 part of EDTA- disodium, 0.1 part of carbomer, Sodium Hyaluronate 0.01 Part, 1 part of glycerol, 1 part of butanediol, the component B quality proportioning are as follows: 1 part of glycine betaine, 0.5 part of niacinamide, 0.5 part of sargassum fusifome, 0.1 part of triethanolamine, 0.1 part of dipotassium glycyrrhizinate, 0.01 part of tropolone, 0.05 part of decoyl hydroximic acid, ethylene glycol 0.5 Part, the component C quality proportioning: 0.1 part of ferulic acid, 0.1 part of olibanum essential oil, 0.1 part of zinc gluconate, PEG-40 hydrogenate castor 0.1 part of sesame oil, the component D quality proportioning are as follows: 0.5 part of overlay film saccharomycetes to make fermentation Product filtrate, 0.01 part of Rumex patinetia, blueness 0.01 part of black pigment used by women in ancient times to paint their eyebrows, 0.01 part of Herba portulacae, 0.01 part of dandelion, 0.01 part of Asian puccoon, 0.01 part of cortex dictamni, 0.01 part of hypoglaucous collett yam rhizome, kuh-seng 0.01 part, 0.01 part of folium artemisiae argyi, 0.01 part of cacumen biotae, 0.01 part of Radix Glycyrrhizae, 0.01 part of frutus cnidii, 0.01 part of the fruit of summer cypress, the coptis 0.01 It is part, 0.01 part of rheum officinale, 0.01 part of radix scutellariae, 0.01 part of Cortex Phellodendri, 0.01 part of honeysuckle, 0.01 part of the Chinese bulbul, 0.01 part of wild chrysanthemum, white It is flower 0.01 0.01 part of Fen, Common St.Paulswort Herb of HERBA HEDYOTIS DIFFUSAE, 0.01 part of the root bark of Chinese wolf-berry, 0.01 part of safflower, 0.01 part of glutinous rehmannia, 0.01 part of rhizoma atractylodis, thin 0.01 part of lotus, 0.01 part of Radix Salviae Miltiorrhizae, 0.01 part of Radix Angelicae Sinensis, 0.01 part of Caulis Spatholobi, 0.01 part of wilsonii, 0.01 part of paris polyphylla, Xu 0.01 part of long minister in ancient times, 0.01 part of Chinese prickly ash fruit.

4. the composition and preparation method and application, feature of a kind for the treatment of as claimed in claim 2 and improvement psoriasis exist In: the component A quality proportioning are as follows: 150 parts of Purified Water, 0.2 part of EDTA- disodium, 0.4 part of carbomer, Sodium Hyaluronate 0.15 part, 10 parts of glycerol, 6 parts of butanediol, the component B quality proportioning are as follows: 4 parts of glycine betaine, 1.5 parts of niacinamide, sargassum fusifome 1.5 parts, 0.4 part of triethanolamine, 1 part of dipotassium glycyrrhizinate, 0.2 part of tropolone, 0.2 part of decoyl hydroximic acid, ethylene glycol 1.5 Part, the component C quality proportioning: 0.4 part of ferulic acid, 0.4 part of olibanum essential oil, 0.4 part of zinc gluconate, PEG-40 hydrogenate castor 1 part of sesame oil, the component D quality proportioning are as follows: 1.5 parts of overlay film saccharomycetes to make fermentation Product filtrate, 0.06 part of Rumex patinetia, indigo naturalis 0.1 part, 0.1 part of Herba portulacae, 0.1 part of dandelion, 0.1 part of Asian puccoon, 0.06 part of cortex dictamni, 0.1 part of hypoglaucous collett yam rhizome, 0.1 part of kuh-seng, Chinese mugwort 0.1 part of leaf, cacumen biotae 0.06,0.1 part of Radix Glycyrrhizae, 0.1 part of frutus cnidii, 0.06 part of the fruit of summer cypress, 0.1 part of the coptis, 0.1 part of rheum officinale, Huang 0.1 part of a kind of reed mentioned in ancient books, 0.1 part of Cortex Phellodendri, 0.1 part of honeysuckle, 0.06 part of the Chinese bulbul, 0.06 part of wild chrysanthemum, 0.1 Fen, pig Xian of oldenlandia diffusa Careless 0.1 part, 0.1 part of the root bark of Chinese wolf-berry, 0.1 part of safflower, 0.1 part of glutinous rehmannia, 0.1 part of rhizoma atractylodis, 0.1 part of peppermint, 0.1 part of Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis 0.1 Part, 0.1 part of Caulis Spatholobi, 0.1 part of wilsonii, 0.1 part of paris polyphylla, 0.1 part of paniculate swallowwort, 0.1 part of Chinese prickly ash fruit.

5. the composition and preparation method and application, feature of a kind for the treatment of as claimed in claim 2 and improvement psoriasis exist In: the component A quality proportioning are as follows: 130 parts of Purified Water, 0.1 part of EDTA- disodium, 0.3 part of carbomer, Sodium Hyaluronate 0.1 Part, 8 parts of glycerol, 4 parts of butanediol, the component B quality proportioning are as follows: 3 parts of glycine betaine, 1.3 parts of niacinamide, 1.3 parts of sargassum fusifome, 0.3 part of triethanolamine, 0.8 part of dipotassium glycyrrhizinate, 0.18 part of tropolone, 0.18 part of decoyl hydroximic acid, ethylene glycol 1.3 Part, the component C quality proportioning: 0.3 part of ferulic acid, 0.3 part of olibanum essential oil, 0.3 part of zinc gluconate, PEG-40 hydrogenate castor 1.3 parts of sesame oil, the component D quality proportioning are as follows: 1.3 parts of overlay film saccharomycetes to make fermentation Product filtrate, 0.04 part of Rumex patinetia, blueness 0.08 part of black pigment used by women in ancient times to paint their eyebrows, 0.08 part of Herba portulacae, 0.08 part of dandelion, 0.08 part of Asian puccoon, 0.04 part of cortex dictamni, 0.08 part of hypoglaucous collett yam rhizome, kuh-seng 0.08 part, 0.08 part of folium artemisiae argyi, 0.04 part of cacumen biotae, 0.08 part of Radix Glycyrrhizae, 0.08 part of frutus cnidii, 0.04 part of the fruit of summer cypress, the coptis 0.08 It is part, 0.08 part of rheum officinale, 0.08 part of radix scutellariae, 0.08 part of Cortex Phellodendri, 0.08 part of honeysuckle, 0.04 part of the Chinese bulbul, 0.04 part of wild chrysanthemum, white It is flower 0.08 0.08 part of Fen, Common St.Paulswort Herb of HERBA HEDYOTIS DIFFUSAE, 0.08 part of the root bark of Chinese wolf-berry, 0.08 part of safflower, 0.08 part of glutinous rehmannia, 0.08 part of rhizoma atractylodis, thin 0.08 part of lotus, 0.08 part of Radix Salviae Miltiorrhizae, 0.08 part of Radix Angelicae Sinensis, 0.08 part of Caulis Spatholobi, 0.08 part of wilsonii, 0.08 part of paris polyphylla, Xu 0.08 part of long minister in ancient times, 0.08 part of Chinese prickly ash fruit.

6. the composition and preparation method and application, feature of a kind for the treatment of as claimed in claim 2 and improvement psoriasis exist In: the component A quality proportioning are as follows: 100 parts of Purified Water, 0.1 part of EDTA- disodium, 0.2 part of carbomer, Sodium Hyaluronate 0.05 part, 5 parts of glycerol, 3 parts of butanediol, the component B quality proportioning are as follows: 2 parts of glycine betaine, 1 part of niacinamide, 1 part of sargassum fusifome, 0.2 part of triethanolamine, 0.5 part of dipotassium glycyrrhizinate, 0.1 part of tropolone, 0.15 part of decoyl hydroximic acid, 1 part of ethylene glycol, institute The component C quality proportioning stated: 0.2 part of ferulic acid, 0.2 part of olibanum essential oil, 0.2 part of zinc gluconate, PEG-40 rilanit special 0.5 part, the component D quality proportioning are as follows: 1 part of overlay film saccharomycetes to make fermentation Product filtrate, 0.03 part of Rumex patinetia, indigo naturalis 0.05 Part, 0.05 part of Herba portulacae, 0.05 part of dandelion, 0.05 part of Asian puccoon, 0.03 part of cortex dictamni, 0.05 part of hypoglaucous collett yam rhizome, 0.05 part of kuh-seng, 0.05 part of folium artemisiae argyi, 0.05 part of cacumen biotae, 0.05 part of Radix Glycyrrhizae, 0.05 part of frutus cnidii, 0.05 part of the fruit of summer cypress, 0.05 part of the coptis, rheum officinale 0.05 part, 0.05 part of radix scutellariae, 0.05 part of Cortex Phellodendri, 0.05 part of honeysuckle, 0.03 part of the Chinese bulbul, 0.03 part of wild chrysanthemum, oldenlandia Careless 0.05 0.05 part of Fen, Common St.Paulswort Herb, 0.05 part of the root bark of Chinese wolf-berry, 0.05 part of safflower, 0.05 part of glutinous rehmannia, 0.05 part of rhizoma atractylodis, peppermint 0.05 Part, 0.05 part of Radix Salviae Miltiorrhizae, 0.05 part of Radix Angelicae Sinensis, 0.05 part of Caulis Spatholobi, 0.05 part of wilsonii, 0.05 part of paris polyphylla, paniculate swallowwort 0.05 part, 0.05 part of Chinese prickly ash fruit.

7. a kind of preparation method of the composition for the treatment of and alleviation acne, comprising the following steps:

(5) mixture in step (4) is isolated and purified, centrifugal rotational speed is 3000 revs/min, and centrifugation time is 30 minutes, is done It is dry, particle is made to get finished product.