CN116999508A - Chinese medicinal composition for treating gynecological diseases, and its preparation method and application - Google Patents

Chinese medicinal composition for treating gynecological diseases, and its preparation method and application Download PDF

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CN116999508A
CN116999508A CN202311043285.2A CN202311043285A CN116999508A CN 116999508 A CN116999508 A CN 116999508A CN 202311043285 A CN202311043285 A CN 202311043285A CN 116999508 A CN116999508 A CN 116999508A
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chinese medicine
medicine composition
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易瑶
张弋峰
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Jiangxi University of Traditional Chinese Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating gynecological diseases and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 30-50 parts of virgate wormwood herb, 8-19 parts of amur corktree bark, 16-30 parts of largehead atractylodes rhizome, 16-30 parts of Chinese yam, 10-25 parts of common fennel fruit, 20-24 parts of Indian buead, 9-17 parts of cassia twig and 7-12 parts of liquoric root. The invention has the advantages of strengthening spleen and stomach while dispelling damp-heat, adopting the thought of strengthening spleen and eliminating dampness, removing dampness and expelling turbidity, and simultaneously assisting with qi-moving medicines to promote the vital energy in the body of a patient to run, balancing yin and yang while warming and nourishing spleen and stomach, balancing yin and yang and eliminating diseases. The medicines are combined, and the monarch, minister, assistant and guide are matched in a synergistic way, so that the Chinese medicine composition has the effects of tonifying the middle-jiao and clearing away the heat and the symptoms and root causes.

Description

Chinese medicinal composition for treating gynecological diseases, and its preparation method and application
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating gynecological diseases, and a preparation method and application thereof.
Background
Gynecological inflammation is the most common disease of women, mainly refers to inflammation of female genitals, and various organs of women can generate acute and chronic inflammation, specifically including female vulvitis, colpitis, cervicitis and pelvic inflammation; colpitis can be classified into fungal colpitis, bacterial colpitis and trichomonas colpitis according to pathogens, and has the characteristics of high incidence rate, difficult radical cure, easy recurrence and the like. Ancient people were the only theory of "Ning Zhi Shi Man, but not one Fu ren", and the difficulty in treating gynecological diseases was seen. The current treatment is divided into western medicines and traditional Chinese medicines. Western medicines are mainly antibiotics, the antibacterial and anti-inflammatory effects of the medicines are very obvious, the effects are quick, but the treatment difficulty is increased due to the drug resistance caused by excessive dependence on antibiotics, the treatment method can treat symptoms without root cause and has larger side effects, and the cured women are easy to have maleation characteristics: such as growing beard, protruding laryngeal knots, thickening sounds, etc. And meanwhile, the premature ovarian failure is easy to cause, after estrogen is reduced, the cardiovascular morbidity is increased, and the patients are easy to have adverse reactions such as obesity, hypertension, heart disease, osteoporosis and the like. The traditional Chinese medicine is more popular because of the advantages of difficult generation of drug resistance, small side effect and treatment of both principal and secondary aspect of disease.
The prior art discloses a traditional Chinese medicine composition for relieving gynecological itching, a gynecological itching relieving lotion and a preparation process and a control method of the process, and refers to Chinese patent CN109700849A. The traditional Chinese medicine composition comprises the following raw materials: 25-35 parts of kuh-seng, 25-35 parts of honeysuckle, 25-35 parts of dandelion and 10-20 parts of fructus cnidii; the parts are parts by weight. The scheme aims at pruritus caused by damp-heat in lower jiao, and cold and cool medicines are adopted as raw materials, so that the traditional Chinese medicine has the effects of clearing heat, eliminating dampness, dispelling wind and relieving itching, but the problem of spleen and stomach transportation and transformation is not fundamentally solved, and the disease mechanism of gynecological inflammation is that spleen and stomach cannot transport and transform damp, so that the damp is abundant in the body and the damp is long-term transformed into heat. Therefore, development of a traditional Chinese medicine composition for treating gynecological diseases, which can remove damp-heat and enhance spleen and stomach transportation and transformation capacity, is needed to fundamentally solve the problems.
Disclosure of Invention
The invention discloses a traditional Chinese medicine composition for treating gynecological diseases, a preparation method and application thereof, and solves the problems that only cold and cool medicines are used in the treatment of the gynecological diseases in the prior art, and the traditional Chinese medicine composition has the effects of clearing heat, eliminating dampness, dispelling wind and relieving itching, but does not fundamentally solve the problem of spleen and stomach transportation.
A traditional Chinese medicine composition for treating gynecological diseases comprises the following raw materials in parts by weight: 30-50 parts of virgate wormwood herb, 8-19 parts of amur corktree bark, 16-30 parts of largehead atractylodes rhizome, 16-30 parts of Chinese yam, 10-25 parts of common fennel fruit, 20-24 parts of Indian buead, 9-17 parts of cassia twig and 7-12 parts of liquoric root.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 36-44 parts of virgate wormwood herb, 12-15 parts of amur corktree bark, 20-26 parts of largehead atractylodes rhizome, 21-25 parts of Chinese yam, 16-19 parts of common fennel fruit, 21-23 parts of Indian buead, 12-14 parts of cassia twig and 9-10 parts of liquoric root.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 44 parts of virgate wormwood herb, 15 parts of amur corktree bark, 26 parts of largehead atractylodes rhizome, 25 parts of Chinese yam, 19 parts of common fennel, 23 parts of Indian buead, 14 parts of cassia twig and 10 parts of liquoric root.
The second purpose of the invention is to protect the preparation method of the traditional Chinese medicine composition, which comprises the following steps:
s1, crushing phellodendron bark according to the formula amount, adding absolute ethyl alcohol, heating and refluxing, and filtering while the phellodendron bark is hot to obtain a filtrate A; wherein, the phellodendron bark is absolute ethanol=1g:12mL;
s2, crushing fennel in a formula amount, soaking in ethyl acetate for 36-48 hours, performing ultrasonic extraction, and removing a solvent to obtain a filtrate B; wherein, fennel is ethyl acetate=1g:8ml;
s3, mixing the herba artemisiae scopariae with water according to the formula, heating and refluxing for 1-2 h, and filtering to obtain herba artemisiae scopariae extracting solution; wherein, capillary artemisia water=1g:6ml;
the extraction method of the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice is consistent with the extraction method of the capillary artemisia, and the extracting solutions of the capillary artemisia, the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice are mixed to obtain filtrate C;
s4, mixing the filtrate A, the filtrate B and the filtrate C to obtain the traditional Chinese medicine composition.
Preferably, the heating reflux condition in S1 is 72 to 75 ℃ for 2 to 4 hours.
Preferably, the temperature of the hot filtration in S1 is 50-75 ℃.
Preferably, the conditions of the ultrasonic extraction in S2 are: 45-50 ℃, 150Hz and 30-45 min.
The third purpose of the invention is to protect the application of the traditional Chinese medicine composition in preparing medicines for treating gynecological diseases.
Preferably, the prepared traditional Chinese medicine composition is used for preparing medicines for treating gynecological inflammation caused by damp-heat.
The raw materials and the mechanism thereof are as follows:
capillary artemisia: bitter and pungent properties and slight cold property. It enters spleen, stomach, liver and gallbladder meridians. Herba Artemisiae Scopariae has bitter taste, slight cold, clear and smooth qi, and fragrant smell. It is good at clearing damp-heat to treat jaundice, and is indicated for jaundice, yang jaundice and yin Huang Jie. It also has antipruritic effect and can be used for treating eczema and pruritus.
Cortex Phellodendri: bitter and cold property. Enter kidney and bladder meridians. Cortex Phellodendri is bitter and clear for dispelling cold and is dry for sedimentation. Not only clear excess heat and remove heat toxin, but also dry dampness and remove dampness and toxin and remove damp-heat toxin, and clear kidney fire and remove deficiency heat. It is better at clearing heat from the kidney and lower energizer bladder, removing deficiency heat and damp-heat from lower energizer. It is suitable for excessive heat, damp-heat and deficiency heat because it integrates excessive heat, damp-heat and deficiency heat.
White atractylodes rhizome: bai Zhu is bitter and sweet in property and warm in nature. Enter spleen and stomach meridians. The operation is sweet and tonic, and has the effects of removing dampness, tonifying and promoting diuresis, and bitter and warm and dry, entering spleen and stomach meridians, and mainly warming and tonifying and strengthening body resistance. It is good at invigorating qi and spleen, eliminating dampness and promoting diuresis, and preventing abortion, and can be used for treating spleen and stomach qi deficiency, spleen deficiency edema, phlegm retention, spontaneous perspiration due to exterior deficiency, and fetal movement.
Chinese yam: the Chinese yam is sweet in taste and flat in property, enters spleen, lung and kidney channels, is an important nourishing medicine, and has the effects of nourishing and tonifying kidney, invigorating stomach and reducing phlegm, tonifying middle-jiao and Qi, dispelling cold wind, relieving heart spirit, calming mind, growing muscle and marrow and the like. Clinically, it is used for treating spleen deficiency, anorexia, chronic diarrhea, asthma and cough due to lung deficiency, seminal emission due to kidney deficiency, leukorrhagia, frequent urination, consumptive heat, diabetes, neurasthenia, etc.
Poria cocos: poria is sweet and light in nature and flat. It enters heart, lung, spleen and meridians. Poria, poria cocos, radix et rhizoma Rhei, and Poria cocos, are sweet and light in nature, good in spleen and kidney meridians, and capable of excreting dampness and promoting diuresis to remove water retention, and invigorating spleen to promote water dampness transportation and transformation; it is indicated for heart meridian entered, heart-soothing and tranquillizing, and water-qi-flowing and heart-qi-flowing. It is good at treating edema due to spleen deficiency or excessive dampness, because it is indicated for water-damp and fluid retention, both cold and heat and spleen deficiency.
Fennel: 1. middle warmer warming and qi regulating: the common fennel fruit has warm property, is clinically combined with medicines for warming kidney and dispelling cold, such as cinnamon, agilawood, combined spicebush root, and the like, and can be used for relieving dysmenorrhea caused by cold, rain and wading, blood stasis and qi stagnation of females. 2. Regulating qi and harmonizing stomach: the aromatic oil in fructus Foeniculi can promote secretion of digestive juice, promote gastrointestinal peristalsis, and relieve symptoms such as nausea and emesis due to cold and abdominal pain.
Ramulus Cinnamomi: pungent and sweet in flavor and warm in nature. It enters heart, lung and bladder meridians. Ramulus Cinnamomi is pungent and dispersed and is warm and unblocked, and sweet and warm and can promote yang. Warm, smooth, damp helps yang qi of the body and smooth blood vessels of the body. Enters lung and bladder meridians, and is good at dispersing wind-cold and relieving exterior wind-cold or pathogenic wind. It enters heart meridian and blood system, and is good at warming and activating yang, dispelling cold evil, activating blood vessels, smoothening chest yang, warming and resolving water dampness and relieving pain. Less sweating than Ma Huang, it is good at supporting yang and smoothing blood vessels. It is indicated for exterior syndrome due to wind-cold, exterior syndrome due to deficiency and excess, and cold syndrome due to deficiency, excess or exterior-cold with direct middle energizer or yang deficiency with endogenous sensation. It is indicated for both qi and blood failing to treat blood stasis with cold and yang deficiency with water retention.
Licorice root: sweet and flat property, it enters heart, lung, spleen and stomach meridians. Licorice root, radix Glycyrrhizae Praeparata, sweet in taste, nourishes and moistens slowly, produces a flat and cool sensation, and a flat and warm sensation, and it enters the spleen and lung meridians and stomach and heart meridians. Not only tonify qi and strengthen middle energizer, but also relieve spasm and pain, alleviate drug properties, and also eliminate phlegm and relieve cough and detoxify. The roasted qi-tonifying and urgent-relieving force is strong; it can purge fire and detoxify.
Compared with the prior art, the invention has the following advantages:
the invention has the advantages of strengthening spleen and stomach while dispelling damp-heat, adopting the thought of strengthening spleen and eliminating dampness, removing dampness and expelling turbidity, and simultaneously assisting with qi-moving medicines to promote the vital energy in the body of a patient to run, balancing yin and yang while warming and nourishing spleen and stomach, balancing yin and yang and eliminating diseases. The medicines are combined, and the monarch, minister, assistant and guide are matched in a synergistic way, so that the Chinese medicine composition has the effects of tonifying the middle-jiao and clearing away the heat and the symptoms and root causes.
The invention takes virgate wormwood herb and phellodendron bark as principal drugs, white atractylodes rhizome, chinese yam, poria cocos and common fennel as ministerial drugs, and cassia twig and liquorice as adjuvant and guide drugs. The herba artemisiae scopariae can not only clear damp-heat in liver and gall, but also sooth liver and dredge liver, and liver qi stagnation can lead to reduced dredging capacity, so that damp turbidity in a patient can not be removed in time, and female is extremely prone to liver qi stagnation; chen Ying and Huang Bai are combined to treat damp-heat in middle-lower jiao. Rhizoma dioscoreae is used for warming and tonifying spleen and stomach, bighead atractylodes rhizome is used for strengthening spleen and eliminating dampness as an auxiliary; the nature of the disease is considered as imbalance of yin and yang by the traditional Chinese medicine, and the Chinese yam and the white atractylodes rhizome are compatible and balanced in yin and yang. Poria has effects of promoting diuresis, removing dampness from urine, and nourishing spleen and stomach. When qi is moving, water is stopped when qi stagnates, and fennel is pungent and warm in flavor and moves qi to promote water in the body of a patient to wet and move to urinate. Ramulus Cinnamomi warms and tonifies kidney yang, and kidney yang is sufficient to transform water dampness, and ramulus Cinnamomi is wind-damp-dispelling medicine and wind-damp-dispelling medicine. Licorice regulates the drugs, warms and supplements the spleen and stomach, because the monarch drug capillary artemisia and phellodendron bark are relatively cool and cool, licorice is used for protecting the spleen and stomach, so as to prevent cold and injury to the spleen and stomach.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A traditional Chinese medicine composition for treating gynecological diseases comprises the following raw materials in parts by weight: 30 parts of virgate wormwood herb, 8 parts of amur corktree bark, 16 parts of largehead atractylodes rhizome, 16 parts of Chinese yam, 10 parts of common fennel, 20 parts of Indian buead, 9 parts of cassia twig and 7 parts of liquoric root.
The specific preparation steps of the traditional Chinese medicine composition are as follows:
s1, crushing phellodendron bark according to the formula amount to 60 meshes, adding absolute ethyl alcohol, heating and refluxing for 2-4 hours at 72 ℃, and filtering at 50 ℃ while the phellodendron bark is hot to obtain a filtrate A; wherein, the phellodendron bark is absolute ethanol=1g:12mL.
S2, crushing fennel of formula amount to 100 meshes, soaking in ethyl acetate for 36 hours, then carrying out ultrasonic extraction at 45 ℃ and 150Hz for 30 minutes, and removing the solvent by a rotary evaporator to obtain filtrate B; wherein, fennel is ethyl acetate=1g:8ml.
S3, mixing the herba artemisiae scopariae with water according to the formula, heating and refluxing for 1h at 95 ℃, and filtering to obtain a herba artemisiae scopariae extracting solution; wherein, capillary artemisia, water=1g:6ml.
The extraction method of the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice is consistent with the extraction method of the capillary artemisia, and the extraction liquid of the capillary artemisia, the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice is mixed to obtain the filtrate C.
S4, mixing the filtrate A, the filtrate B and the filtrate C to obtain the traditional Chinese medicine composition.
Example 2
A traditional Chinese medicine composition for treating gynecological diseases comprises the following raw materials in parts by weight: 36 parts of virgate wormwood herb, 12 parts of amur corktree bark, 20 parts of largehead atractylodes rhizome, 21 parts of Chinese yam, 16 parts of common fennel, 21 parts of Indian buead, 12 parts of cassia twig and 9 parts of liquoric root.
The specific preparation steps of the traditional Chinese medicine composition are as follows:
s1, crushing phellodendron bark according to the formula amount to 60 meshes, adding absolute ethyl alcohol, heating and refluxing for 3 hours at 73 ℃, and filtering at the temperature of 60 ℃ to obtain a filtrate A; wherein, the phellodendron bark is absolute ethanol=1g:12mL.
S2, crushing fennel of formula amount to 100 meshes, soaking in ethyl acetate for 40 hours, then carrying out ultrasonic extraction at 45 ℃ and 150Hz for 30 minutes, and removing the solvent by a rotary evaporator to obtain filtrate B; wherein, fennel is ethyl acetate=1g:8ml.
S3, mixing the herba artemisiae scopariae with water according to the formula, heating and refluxing for 1h at 95 ℃, and filtering to obtain a herba artemisiae scopariae extracting solution; wherein, capillary artemisia, water=1g:6ml.
The extraction method of the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice is consistent with the extraction method of the capillary artemisia, and the extraction liquid of the capillary artemisia, the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice is mixed to obtain the filtrate C.
S4, mixing the filtrate A, the filtrate B and the filtrate C to obtain the traditional Chinese medicine composition.
Example 3
A traditional Chinese medicine composition for treating gynecological diseases comprises the following raw materials in parts by weight: 44 parts of virgate wormwood herb, 15 parts of amur corktree bark, 26 parts of largehead atractylodes rhizome, 25 parts of Chinese yam, 19 parts of common fennel, 23 parts of Indian buead, 14 parts of cassia twig and 10 parts of liquoric root.
The specific preparation steps of the traditional Chinese medicine composition are as follows:
s1, crushing phellodendron bark according to the formula amount to 80 meshes, adding absolute ethyl alcohol, heating and refluxing for 4 hours at 74 ℃, and filtering at 75 ℃ while the phellodendron bark is hot to obtain a filtrate A; wherein, the phellodendron bark is absolute ethanol=1g:12mL.
S2, crushing fennel of formula amount to 120 meshes, soaking in ethyl acetate for 44h, then carrying out ultrasonic extraction at 50 ℃ and 150Hz for 45min, and removing the solvent by a rotary evaporator to obtain filtrate B; wherein, fennel is ethyl acetate=1g:8ml.
S3, mixing the herba artemisiae scopariae with water according to the formula, heating and refluxing for 2 hours at 100 ℃, and filtering to obtain a herba artemisiae scopariae extracting solution; wherein, capillary artemisia, water=1g:6ml.
The extraction method of the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice is consistent with the extraction method of the capillary artemisia, and the extraction liquid of the capillary artemisia, the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice is mixed to obtain the filtrate C.
S4, mixing the filtrate A, the filtrate B and the filtrate C to obtain the traditional Chinese medicine composition.
Example 4
A traditional Chinese medicine composition for treating gynecological diseases comprises the following raw materials in parts by weight: 50 parts of virgate wormwood herb, 19 parts of amur corktree bark, 30 parts of largehead atractylodes rhizome, 30 parts of Chinese yam, 25 parts of common fennel, 24 parts of Indian buead, 17 parts of cassia twig and 12 parts of liquoric root.
The specific preparation steps of the traditional Chinese medicine composition are as follows:
s1, crushing phellodendron bark according to the formula amount to 80 meshes, adding absolute ethyl alcohol, heating and refluxing for 4 hours at 75 ℃, and filtering at 75 ℃ while the phellodendron bark is hot to obtain a filtrate A; wherein, the phellodendron bark is absolute ethanol=1g:12mL.
S2, crushing fennel of formula amount to 120 meshes, soaking in ethyl acetate for 48 hours, then carrying out ultrasonic extraction at 50 ℃ and 150Hz for 45 minutes, and removing the solvent by a rotary evaporator to obtain filtrate B; wherein, fennel is ethyl acetate=1g:8ml.
S3, mixing the herba artemisiae scopariae with water according to the formula, heating and refluxing for 2 hours at 100 ℃, and filtering to obtain a herba artemisiae scopariae extracting solution; wherein, capillary artemisia, water=1g:6ml.
The extraction method of the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice is consistent with the extraction method of the capillary artemisia, and the extraction liquid of the capillary artemisia, the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice is mixed to obtain the filtrate C.
S4, mixing the filtrate A, the filtrate B and the filtrate C to obtain the traditional Chinese medicine composition.
Comparative example 1
Reference is made to example 1 in the detailed description of chinese patent CN109700849a.
A gynecological antipruritic traditional Chinese medicine composition comprises the following components in parts by weight: 25-35 parts of kuh-seng, 25-35 parts of honeysuckle, 25-35 parts of dandelion and 10-20 parts of fructus cnidii.
1. Test subjects
200 patients with colpitis are selected, and all the patients meet the diagnosis standard of gynecological inflammation in the science of obstetrics, and the symptoms, diagnosis and inclusion requirements are as follows: itching, pain or burning sensation of vulvar skin; leucorrhea with redness and purulent nature; localized redness and swelling; ulcers may occur in heavy persons; and the colpitis is confirmed by B ultrasonic examination, colposcope examination, pathological biopsy examination and other examination, pregnant women and lactating women are excluded, allergic constitution women are aged between 20 and 50 years, and the patients are randomly divided into 5 groups of 40 people each.
2. Test method
4 groups of patients are allowed to use the traditional Chinese medicine composition prepared in the examples 1-4, the prepared traditional Chinese medicine composition is heated to 35-40 ℃ to be taken, 1 dose is taken every day, 7 days is a treatment course, and the total treatment course is 4.
Group 1 used the traditional Chinese medicine composition of comparative example 1, and the administration method was: decoct with water, 1 dose per day, 7 days as a treatment course, and treat for 4 treatment courses.
3. Observation index and therapeutic effect determination criterion
The overall efficacy of each group was observed, adverse drug reactions and recurrence rates for 6 months of follow-up.
Overall efficacy criteria:
and (3) healing: the symptoms such as itching, burning and the like completely disappear, vaginal secretion is not abnormal, and the symptoms do not relapse after stopping taking medicines for 6 menstrual periods;
the effect is shown: the symptoms such as itching, burning and the like are obviously improved, and vaginal secretion is not abnormal;
the method is effective: symptoms such as itching, burning and the like are improved, and vaginal secretion is slightly abnormal;
invalidation: without any improvement.
4. Therapeutic results
The treatment results are shown in table 1.
TABLE 1 therapeutic effects of different groups
As can be seen from Table 1, the cure rate of the Chinese medicinal compositions prepared in examples 1 to 4 was higher for patients than that of comparative example 1, and more importantly, the recurrence rate of patients using the Chinese medicinal compositions prepared in examples 1 to 4 was far lower than that of the Chinese medicinal composition of comparative example 1 after 6 months of follow-up. It is possible that the traditional Chinese medicine compositions of examples 1 to 4 not only use the raw material medicines for eliminating dampness and clearing heat, have effects on symptoms such as itching, burning and the like, but also use the medicines for strengthening spleen, promoting qi and balancing yin and yang, thereby improving the spleen and stomach transportation capability of patients and radically avoiding the generation of damp-heat.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.

Claims (9)

1. The traditional Chinese medicine composition for treating the gynecological diseases is characterized by comprising the following raw materials in parts by weight: 30-50 parts of virgate wormwood herb, 8-19 parts of amur corktree bark, 16-30 parts of largehead atractylodes rhizome, 16-30 parts of Chinese yam, 10-25 parts of common fennel fruit, 20-24 parts of Indian buead, 9-17 parts of cassia twig and 7-12 parts of liquoric root.
2. The traditional Chinese medicine composition for treating gynecological diseases according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 36-44 parts of virgate wormwood herb, 12-15 parts of amur corktree bark, 20-26 parts of largehead atractylodes rhizome, 21-25 parts of Chinese yam, 16-19 parts of common fennel fruit, 21-23 parts of Indian buead, 12-14 parts of cassia twig and 9-10 parts of liquoric root.
3. The traditional Chinese medicine composition for treating gynecological diseases according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 44 parts of virgate wormwood herb, 15 parts of amur corktree bark, 26 parts of largehead atractylodes rhizome, 25 parts of Chinese yam, 19 parts of common fennel, 23 parts of Indian buead, 14 parts of cassia twig and 10 parts of liquoric root.
4. A method for preparing a traditional Chinese medicine composition for treating gynecological diseases according to claims 1-3, which is characterized by comprising the following steps:
s1, crushing phellodendron bark with a formula amount, adding absolute ethyl alcohol, heating and refluxing, and filtering while the phellodendron bark is hot to obtain a filtrate A; wherein, the phellodendron bark is absolute ethanol=1g:12mL;
s2, crushing fennel in a formula amount, soaking in ethyl acetate for 36-48 hours, performing ultrasonic extraction, and removing a solvent to obtain a filtrate B; wherein, fennel is ethyl acetate=1g:8ml;
s3, mixing the herba artemisiae scopariae with water according to the formula, heating and refluxing for 1-2 h, and filtering to obtain herba artemisiae scopariae extracting solution; wherein, capillary artemisia water=1g:6ml;
the extraction method of the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice is consistent with the extraction method of the capillary artemisia, and the extracting solutions of the capillary artemisia, the white atractylodes rhizome, the Chinese yam, the tuckahoe, the cassia twig and the liquorice are mixed to obtain filtrate C;
s4, mixing the filtrate A, the filtrate B and the filtrate C to obtain the traditional Chinese medicine composition.
5. The method for preparing a Chinese medicinal composition for treating gynecological diseases according to claim 4, wherein the heating reflux condition in S1 is 72-75 ℃ for 2-4 h.
6. The method for preparing a Chinese medicinal composition for treating gynecological diseases according to claim 5, wherein the temperature of the hot filtration in S1 is 50-75 ℃.
7. The method for preparing a Chinese medicinal composition for treating gynecological diseases according to claim 4, wherein the ultrasonic extraction conditions in S2 are as follows: 45-50 ℃, 150Hz and 30-45 min.
8. The use of the Chinese medicinal composition according to claim 1 for preparing a medicament for treating gynecological diseases.
9. The use of the Chinese medicinal composition according to claim 8, wherein the prepared Chinese medicinal composition is used for preparing a medicament for treating gynecological inflammation caused by damp-heat.
CN202311043285.2A 2023-08-18 2023-08-18 Chinese medicinal composition for treating gynecological diseases, and its preparation method and application Withdrawn CN116999508A (en)

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