CN101028349B - Externally-applied medicine for treating prostatitis and prostatic accrementition and preparation method thereof - Google Patents
Externally-applied medicine for treating prostatitis and prostatic accrementition and preparation method thereof Download PDFInfo
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- CN101028349B CN101028349B CN2007100140721A CN200710014072A CN101028349B CN 101028349 B CN101028349 B CN 101028349B CN 2007100140721 A CN2007100140721 A CN 2007100140721A CN 200710014072 A CN200710014072 A CN 200710014072A CN 101028349 B CN101028349 B CN 101028349B
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Abstract
An exterior-applied Chinese medicine in the form of suppository, ointment, or plaster for treating prostatitis and prostatoplasia is prepared from 5 Chinese-medicinal materials including frankincense, myrrh, lindera root, white peony root, etc. Its preparing process is also disclosed.
Description
Technical field:
The present invention relates to medicine, especially a kind of treatment prostatitis with herbal raw material preparation, the medicine of prostatic hyperplasia the invention still further relates to the preparation method of this medicine.
Background technology:
Chronic prostatitis, prostatic hyperplasia are the common diseases of male genitourinary system, the sickness rate height.Modern medicine is in the treatment prostatosis, though method is many, curative effect is dissatisfied.Its main cause: 1. cause of disease complexity often is difficult in clinical clear and definite.2. pathological change is many with the retention of gland liquid, and inflammation parcel and body of gland fiber turn to the master.3.McNcal (1972) think on the prostate anatomy the perimeter region glandular tube and urethra meets at right angles even bevel, be unfavorable for the discharge of secretions, and cause easily that urine is counter to flow.4. inflammatory EPS-PH value increases and is alkalescence, is unfavorable for that medicine permeates in prostate, and many adverse effects have increased difficulty to treatment.Male more than 35 years old has 35-40% to suffer from primary disease according to statistics, 1/4 of urology department outpatient service disease is a prostatitis, this sick cause of disease, pathology complexity, course of disease delay, obstinate difficult, aspect clinical treatment, lack effective medicine and method both at home and abroad always, bring very big misery to patient, so be badly in need of a kind of clinical effective medicine of development, promote the well-being of mankind.
Goal of the invention:
It is raw material with the Chinese herbal medicine that one of purpose of the present invention provides a kind of, and prostatitis, prostatic hyperplasia are played better treatment and medicine without any side effects; Two of purpose provides the preparation method of this medicine that one of achieves the goal.
One of purpose of the present invention can realize by following technical measures:
The external used medicine of this treatment prostatitis, prostatic hyperplasia is tract and the topical agent that has following weight parts proportioning herbal raw material to make:
Olibanum 1-15 Myrrha 1-20 Radix Linderae 1-15
Rhizoma Corydalis 1-10 Radix Paeoniae Alba 1-15.
One of purpose of the present invention also can realize by following technical measures:
Olibanum 10, Myrrha 10, the Radix Linderae 8, Rhizoma Corydalis 6, the Radix Paeoniae Alba 8.
Olibanum: acrid in the mouth, hardship, temperature.GUIXIN, liver, spleen channel.Has promoting blood circulation and stopping pain, the function of detumescence and promoting granulation.Be used for traumatic injury, carbuncle, cardiac and abdominal pain, contracture, the skin infection diabrosis is not closed up for a long time.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge." not Lu ": " it be swollen to treat the edema due to wind pathogen poison, removes bad odor." " treat the wind addiction? the poison of itching." supplement to the Herbal: " and treat deaf, the apoplexy locked mouth, married woman's vim and vigour can be sent out wine, manage air-cooledly, only is large intestine let out?, treat all skin ulcers and make internal diabetes." " Japan hanako materia medica ": " end cholera, cardiac and abdominal pain.The soft extracts pain relieving is put on flesh." " pearl sac ": " fixed all warps are pain." " detailed outline ": " and all poison of eliminating carbuncle cellulitis, the heart is protected in the Tuoli, and muscle is stretched in the analgesic therapy of invigorating blood circulation, and controls married woman's difficult labour, and folding is hindered." " key medicine is divided agent ": " dysentery with red and white feces more than person that suffers from abdominal pain adds Olibanum and imitates invariably.”
Myrrha (MYRRHA): property is flat, bitter in the mouth.Has removing blood stasis, detumescence, granulation promoting, analgesic effect.Compendium of Material Medica is said Myrrha " the blood detumescence of loosing, analgesic therapy granulation promoting ".
The Radix Linderae (RADIX LINDERAE): hot, warm.Return lung, spleen, kidney, urinary bladder channel.Function with pleasant pain relieving, warming kidney for dispelling cold.Be used for chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, dysmenorrhea.
Rhizoma Corydalis (RHIZOMA CORYDALIS): warm in nature, acrid in the mouth, hardship.Have invigorate blood circulation, the function of promoting the circulation of QI, pain relieving.Be used for breast association wrist abdomen pain, amenorrhea stimulates the menstrual flow, postpartum stagnation, tumbling and swelling." Kaibao Bencao ", warm in nature, the acrid in the mouth hardship is gone into the heart, spleen, liver, lung, is the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, is world-famous for the effect of pain relieving especially.Li Shizhen (1518-1593 A.D.) is concluded Rhizoma Corydalis in Compendium of Material Medica have " invigorating blood circulation promoting the circulation of QI, pain relieving, diuresis " four large effects, and praise highly Rhizoma Corydalis " stagnation of QI in the energy promoting the circulation of blood, stasis in the gas is so specially control the whole body all pains up and down ".
The Radix Paeoniae Alba (RADIX PAEONINE ALBA): hot, sour, be slightly cold.Return liver, spleen channel.The suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.It is dizzy to be used to have a headache, hypochondriac pain, and stomachache is meant spasm and pain, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
With Olibanum, Myrrha stasis-dispelling and pain-killing, detumescence and promoting granulation is principal agent, and auxilliary 5 with the Radix Linderae, Rhizoma Corydalis, the pain relieving of Radix Paeoniae Alba blood circulation promoting regulates qi.All medicines share, the promoting blood circulation and detumescence dissipating blood stasis, and regulating QI to relieve pain is to reach the elimination symptom, the purpose of cure diseases.
Said medicament is said tract and a topical agent on any pharmaceutics; Said medicament is suppository, ointment, emplastrum etc.
Two of purpose of the present invention can realize by following technical measures:
Get Olibanum, Myrrha, the Radix Linderae, Rhizoma Corydalis, Radix Paeoniae Alba conventional method earlier and extract, again extracting solution is condensed into thick paste or dry system fine powder, then routinely with the substrate ground and mixed of fusing, molding, product.
Two of purpose of the present invention also can realize by following technical measures:
Conventional method in the preparation method of medicine of the present invention is extracted and is comprised extracting method all in the pharmaceutical book, as backflow, extraction, percolation or supercritical extraction etc.
Active component of the present invention can add different substrates according to the different dosage form of preparation, suppository base if necessary, ointment base, plaster stroma etc. are prepared into any tract commonly used and exterior-applied formulation by the Chinese medicine preparation common method, as suppository, ointment, emplastrum etc.
The preparation method of medicine of the present invention can be the ormal weight according to each component in one of above-mentioned purpose, gets Olibanum, Myrrha, Rhizoma Corydalis and adds 3-8 respectively and doubly measure the ethanol that concentration is 50-95%, extracts 1-3 time, each 1-3 hour, filter, merging filtrate reclaims ethanol; Get the Radix Paeoniae Alba, Radix Linderae decocting boils 2-3 time, each 0.5-1.5 hour, filter, merge decoction liquor, concentrate the back precipitate with ethanol, get supernatant and reclaim ethanol, merge with filtrate and to be condensed into thick paste or dry system fine powder, more routinely with the substrate ground and mixed of fusing, make the medicament of requirement.
The preparation method of medicine of the present invention can also be the ormal weight according to each component in one of above-mentioned purpose, getting Olibanum, Myrrha, Rhizoma Corydalis, the Radix Linderae, Radix Paeoniae Alba coarse powder adds 1-2 and doubly measures the ethanol that concentration is 50-95%, stir, moistened vexed 0.5-2 hour, evenly add in the percolation filter, add 2-7 again and doubly measure the ethanol that concentration is 50-95%, soaked 12-48 hour, the beginning diafiltration, filtrate is condensed into thick paste or dry system fine powder, last routinely with the substrate ground and mixed of fusing, make the medicament of requirement.
The preparation method of medicine of the present invention also can be the ormal weight according to each component in one of above-mentioned purpose, getting Olibanum, Myrrha adds 0.5-3 doubly to measure concentration is that the ethanol of 50-95% extracted 2-5 hour by super critical extraction, Rhizoma Corydalis adds 3-8 and doubly measures the ethanol that concentration is 50-80%, reflux, extract, 1-3 time, each 1-3 hour, filter, merging filtrate reclaims ethanol; Get the Radix Paeoniae Alba, Radix Linderae decocting boils 2-3 time, each 0.5-1.5 hour, filter, get decoction liquor, concentrate the back precipitate with ethanol, get supernatant and reclaim ethanol, merge with filtrate and to be condensed into thick paste or dry system fine powder, more routinely with the substrate ground and mixed of fusing, make the medicament of requirement.
Pharmacodynamic test of active extract result:
This product can obviously suppress four kinds of different inflammatory reactions under 3～9g/kg/ daily dose.Can significantly suppress the mice foot swelling that carrageenin causes and alleviate mice dimethylbenzene ear swelling, reduce the mice capillary permeability; Suppress the granulomatous generation of cotton balls, demonstrate effects such as tangible anti-inflammation detumescence and anti-proliferation of fibrous tissue; This product can promote the generation of the macrophage phagocytic function of mice of immunologic hypofunction and hemolysin and improve the non-specific immunity and the humoral immune function of immunologic hypofunction, this product can suppress the DTH reaction of mice and suppress cell immune function of human body, show that this product has the immunologic function Accommodation, this Accommodation helps the improvement of inflammation; This product can obviously alleviate the mice prostatic hyperplasia that third testis causes, the prostatic hyperplasia that third testis is caused has the better prevention effect; This product acute toxicity test shows: according to the tolerance test requirement, when mice can tolerate 60～100 times of adult's dosage (converting by body weight), it is qualified to admit that this tolerance test screens.The consumption of this product far surpasses aforementioned requirement, so can think that this medicine is safer.
Toxicological study:
In 180 days of successive administration, the animal appearance activity is no abnormal, dissects perusal during off-test, and no abnormal discovery is got important organ (heart, liver, lung, kidney, testis, ovary etc.) pathology microscopy and also do not found the pathological change relevant with medicine.
Clinical trial:
Observe through clinical trial, the adult uses dosage of the present invention, each 1-10 gram, and every day 1-2 time, logotype 28 days was a course of treatment, and the total effective rate of this product treatment chronic prostatitis 30 examples is 95.4%, and the total effective rate of treatment prostatic hyperplasia 20 examples is 88.3%.Clinical trial proves: this product treatment chronic prostatitis is the best with the turbid stasis of blood cohesion of Chinese medical discrimination type, damp heat downward flowing type.Clinical observation is evident in efficacy to the improvement of its main disease, all reach more than 90% as the effective percentage of pudendum distending pain, lower abdomen contracture, waist dull pain and dribbling urination, puckery pain, with matched group relatively, significant difference (P＜0.01); To the local sign curative effect of prostate, be respectively 71.7% and 91.8% as the hard effective percentage tough and tenderness of body of gland, obviously be better than matched group, two groups of comparing differences remarkable (P＜0.01); Reducing the prostatic fluid leukocyte count, increase the lecithin aspect, treatment group effective percentage is respectively 95.0% and 92.8%, and matched group is respectively 58.9% and 56.1%, and the two comparing difference is (P＜0.01) significantly; Aspect the prostate ultrasound diagnosis, treatment group effective percentage obviously is better than matched group, and two groups relatively, significant difference (P＜0.01).
The relation of this product treatment chronic prostatitis, the prostatic hyperplasia course of treatment and curative effect shows comparatively satisfied with its curative effect after serveing on three courses of treatment from clinical test results.
During this product clinical trial, blood, routine urinalysis, liver, renal function, electrocardiogram there is no unusually before and after treatment.Illustrate that this medicine is harmless to people body-centered, liver, renal function.Also there is not obvious adverse reaction clinically.
The specific embodiment:
Embodiment 1:
Get 1 kilogram of Olibanum, 20 kilograms of Myrrhas, add 63 kilogram weights of concentration and be 95% ethanol and extracted 2 hours, get 1 kilogram of Rhizoma Corydalis with super critical extraction, add 8 kilogram weights of concentration and be 95% ethanol, reflux, extract, is 3 times respectively, each 1 hour, filter, merging filtrate reclaims ethanol; Get 15 kilograms of the Radix Paeoniae Albas, the Radix Linderae 1 kg of water and decoct 3 times, each 0.5 hour, filter, decoction liquor, concentrate the back precipitate with ethanol, get supernatant and reclaim ethanol, be condensed into thick paste with filtrate merging, last routinely with the substrate ground and mixed of fusing, make the suppository of requirement.
Embodiment 2:
Get 15 kilograms of Olibanums, 1 kilogram of Myrrha, add 8 kilogram weights of concentration and be 50% ethanol and extracted 5 hours, get 10 kilograms of Rhizoma Corydalis with super critical extraction, add 3 kilogram weights of concentration and be 50% ethanol, reflux, extract, 1 time, the time is 1.5 hours, filter, merging filtrate reclaims ethanol; Get 1 kilogram of the Radix Paeoniae Alba, the Radix Linderae 15 kg of water and decoct 2 times, each 1.5 hours, filter, decoction liquor, concentrate the back precipitate with ethanol, get supernatant and reclaim ethanol, be condensed into thick paste with filtrate merging, last routinely with the substrate ground and mixed of fusing, make the suppository of requirement.
Embodiment 3:
Get 7 kilograms of Olibanums, 10 kilograms of Myrrhas, add 34 kilogram weights of concentration and be 70% ethanol, get 5 kilograms of Rhizoma Corydalis, add 25 kilogram weights of concentration and be 70% ethanol, reflux, extract, is 2 times respectively, and each 2 hours, filter, merging filtrate reclaims ethanol; Get 7 kilograms of the Radix Paeoniae Albas, the Radix Linderae 7 kg of water and decoct 2 times, each 1 hour, filter, decoction liquor, concentrate the back precipitate with ethanol, get supernatant and reclaim ethanol, be condensed into thick paste with filtrate merging, last routinely with the substrate ground and mixed of fusing, make the suppository of requirement.
Embodiment 4:
Getting 1 kilogram of coarse powder of 1 kilogram of Olibanum, 20 kilograms of Myrrhas, 1 kilogram of Rhizoma Corydalis, 15 kilograms of the Radixs Linderae, the Radix Paeoniae Alba, to add 38 kilogram weights of concentration be 95% ethanol, stir, moistened vexed 2 hours, add then in the percolation filter, add 154 kilogram weights of concentration again and be 95% ethanol, soaked 12 hours, the beginning diafiltration, filtrate is condensed into thick paste, last routinely with an amount of suppository base ground and mixed of fusing, make suppository.
Embodiment 5:
Getting 15 kilograms of coarse powder of 15 kilograms of Olibanums, 1 kilogram of Myrrha, 10 kilograms of Rhizoma Corydalis, 1 kilogram of the Radix Linderae, the Radix Paeoniae Alba, to add 84 kilogram weights of concentration be 50% ethanol, stir, moistened vexed 0.5 hour, add then in the percolation filter, add 84 kilogram weights of concentration again and be 50% ethanol, soaked 48 hours, the beginning diafiltration, filtrate is condensed into thick paste, last routinely with an amount of suppository base ground and mixed of fusing, make suppository.
Embodiment 6:
Getting 7 kilograms of coarse powder of 7 kilograms of Olibanums, 10 kilograms of Myrrhas, 5 kilograms of Rhizoma Corydalis, 7 kilograms of the Radixs Linderae, the Radix Paeoniae Alba, to add 54 kilogram weights of concentration be 70% ethanol, stir, moistened vexed 1.5 hours, add then in the percolation filter, add 180 kilogram weights of concentration again and be 70% ethanol, soaked 24 hours, the beginning diafiltration, filtrate is condensed into thick paste, last routinely with an amount of suppository base ground and mixed of fusing, make suppository.
Embodiment 7:
Get 1 kilogram of Olibanum, 20 kilograms of Myrrhas, 1 kilogram of Rhizoma Corydalis, add 66 kilogram weights of concentration and be 95% ethanol, extract 3 times, each 1 hour, filter, merging filtrate reclaims ethanol; Get 15 kilograms of the Radix Paeoniae Albas, the Radix Linderae 1 kg of water and decoct 3 times, each 0.5 hour, filter, decoction liquor, concentrate the back precipitate with ethanol, get supernatant and reclaim ethanol, be condensed into thick paste with filtrate merging, last routinely with the substrate ground and mixed of fusing, make the suppository of requirement.
Embodiment 8:
Get 15 kilograms of Olibanums, 1 kilogram of Myrrha, 10 kilograms of Rhizoma Corydalis, add 196 kilogram weights of concentration and be 50% ethanol, extract 1 time, the time is 1 hour, filters, and merging filtrate reclaims ethanol; Get 1 kilogram of the Radix Paeoniae Alba, the Radix Linderae 15 kg of water and decoct 2 times, each 1.5 hours, filter, decoction liquor, concentrate the back precipitate with ethanol, get supernatant and reclaim ethanol, be condensed into thick paste with filtrate merging, last routinely with the substrate ground and mixed of fusing, make the suppository of requirement.
Embodiment 9:
Get 7 kilograms of Olibanums, 10 kilograms of Myrrhas, 5 kilograms of Rhizoma Corydalis, add 110 kilogram weights of concentration and be 70% ethanol, extract 2 times, the time is 2 hours, filters, and merging filtrate reclaims ethanol; Get 7 kilograms of the Radix Paeoniae Albas, the Radix Linderae 7 kg of water and decoct 2 times, each 1 hour, filter, decoction liquor, concentrate the back precipitate with ethanol, get supernatant and reclaim ethanol, be condensed into thick paste with filtrate merging, last routinely with the substrate ground and mixed of fusing, make the suppository of requirement.
Embodiment 10:
With embodiment 1-9, different is that drying is made fine powder after being condensed into thick paste with filtrate merging respectively.
Embodiment 11:
With embodiment 1-10, different is to substitute suppository base with ointment base, makes ointment respectively.
Embodiment 12:
With embodiment 1-10, different is to substitute suppository base with plaster stroma, makes emplastrum respectively.
Claims (5)
1. treat the external used medicine of prostatitis, prostatic hyperplasia, it is characterized in that it is the topical agent of being made by following weight parts proportioning herbal raw material:
Olibanum 1-15 Myrrha 1-20 Radix Linderae 1-15
Rhizoma Corydalis 1-10 Radix Paeoniae Alba 1-15.
2. the external used medicine of treatment prostatitis according to claim 1, prostatic hyperplasia, wherein the weight portion proportioning of each raw material is
Olibanum 10 Myrrhas 10 Radixs Linderae 8 Rhizoma Corydalis 6 Radix Paeoniae Albas 8.
3. the external used medicine of treatment prostatitis according to claim 1, prostatic hyperplasia is characterized in that said topical agent is said suppository, ointment or an emplastrum on any pharmaceutics.
4. the preparation method of the external used medicine of the described treatment prostatitis of claim 1, prostatic hyperplasia, it is characterized in that getting earlier Olibanum, Myrrha, the Radix Linderae, Rhizoma Corydalis, the extraction of Radix Paeoniae Alba conventional method, again extracting solution is condensed into thick paste or dry system fine powder, then routinely with the fusing the substrate ground and mixed, molding gets product.
5. according to the preparation method of the external used medicine of the described treatment prostatitis of claim 4, prostatic hyperplasia, it is characterized in that described conventional method is selected from backflow, extraction, diafiltration or super critical extraction.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100140721A CN101028349B (en) | 2007-04-02 | 2007-04-02 | Externally-applied medicine for treating prostatitis and prostatic accrementition and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007100140721A CN101028349B (en) | 2007-04-02 | 2007-04-02 | Externally-applied medicine for treating prostatitis and prostatic accrementition and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101028349A CN101028349A (en) | 2007-09-05 |
| CN101028349B true CN101028349B (en) | 2010-07-07 |
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| CN2007100140721A Active CN101028349B (en) | 2007-04-02 | 2007-04-02 | Externally-applied medicine for treating prostatitis and prostatic accrementition and preparation method thereof |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1406106B1 (en) * | 2010-04-29 | 2014-02-14 | Vi Rus S R L | COMPOSITION OF RECTAL SUPPOSITORS BASED ON NATURAL EXTRACTS FOR THE SOOTHING AND EMOLLIENT TREATMENT OF THE ANO-RECTAL CHANNEL. |
| CN111407809A (en) * | 2020-04-17 | 2020-07-14 | 梁贤 | Prostate suppository containing dalbergia wood and preparation method thereof |
| CN111450188A (en) * | 2020-05-09 | 2020-07-28 | 张良 | A topical Chinese medicinal liquid spray for treating male prostatitis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102102A (en) * | 1993-10-31 | 1995-05-03 | 罗俊红 | Suppository for curing prostatosis |
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2007
- 2007-04-02 CN CN2007100140721A patent/CN101028349B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102102A (en) * | 1993-10-31 | 1995-05-03 | 罗俊红 | Suppository for curing prostatosis |
Non-Patent Citations (2)
| Title |
|---|
| 赵书晓.良性前列腺增生症的中医药治疗概况.中医研究19 3.2006,19(3),60-63. |
| 赵书晓.良性前列腺增生症的中医药治疗概况.中医研究19 3.2006,19(3),60-63. * |
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