CN111450188A

CN111450188A - A topical Chinese medicinal liquid spray for treating male prostatitis

Info

Publication number: CN111450188A
Application number: CN202010388014.0A
Authority: CN
Inventors: 张鸿飞; 张良
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-09
Filing date: 2020-05-09
Publication date: 2020-07-28

Abstract

The invention provides an external traditional Chinese medicine liquid spray for treating male prostatitis, which is prepared by processing Chinese herbal medicine raw materials including cistanche, pseudo-ginseng, dragon's blood, borneol, sappan wood, dried alum, borax, radix pseudostellariae, cinnamon and cowherb seed, soaking the raw materials in a container containing 1000 ml of ethanol for 72 hours, and then filtering out liquid; adding 500 ml of ethanol into the container to soak the Chinese medicinal materials for 72 hours; then the liquid is filtered and poured out, the two liquids are combined and put into a spray bottle, and the external traditional Chinese medicine liquid spray can be obtained. The external traditional Chinese medicine liquid spray for treating prostatitis, which is prepared by the invention, has the effects of resisting bacteria, diminishing inflammation, promoting blood circulation, removing blood stasis, relieving swelling and pain, can effectively treat prostatitis, has a remarkable effect, does not have toxic or side effect, is convenient to use, and is more easily accepted by consumers. The external traditional Chinese medicine liquid spray for treating prostatitis, prepared by the invention, can directly reach the focus in the form of an external liniment, and has short treatment course and quick response.

Description

A topical Chinese medicinal liquid spray for treating male prostatitis

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external traditional Chinese medicine liquid spray for treating male prostatitis.

Background

Chronic prostatitis is a common disease of the male genitourinary system and has high morbidity. Modern medicine has many methods for treating prostate diseases, but the curative effect is not satisfactory. The main reasons are as follows: 1. the etiology is complex, and it is often difficult to define clinically. 2. The pathological changes are mainly caused by the retention of glandular fluid, inflammation and fibrosis of glands. McNcal (1972) believed that the anatomical prostate gland in the peripheral region of the prostate was at right angles or even at an oblique angle to the urethra, was not conducive to the drainage of secretions and was prone to urinary reflux. 4. The increased inflammatory EPS-PH is alkaline, which is not conducive to the penetration of the drug into the prostate, and many adverse effects add difficulty to the treatment. According to statistics, 35-40% of men over 35 years old suffer from the prostatitis, 1/4 of urological clinic diseases is prostatitis, the cause and the pathology of the prostatitis are complex, the course of the disease is prolonged, and the disease is stubborn and difficult to heal, and effective medicines and methods are always lacked at home and abroad in the aspect of clinical treatment, so that great pain is brought to patients, and a clinically effective treatment medicine is urgently needed to be developed to benefit human beings.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides an external traditional Chinese medicine liquid spray for treating male prostatitis.

In order to achieve the purpose, the technical scheme of the invention is as follows:

an external traditional Chinese medicine liquid spray for treating male prostatitis is prepared from the following Chinese herbal medicine raw materials in parts by weight: 6 parts of cistanche, 6 parts of pseudo-ginseng, 5 parts of dragon's blood, 30 parts of borneol, 7.5 parts of sappan wood, 6 parts of dried alum, 6 parts of borax, 3 parts of radix pseudostellariae, 3 parts of cinnamon, 3 parts of cowherb seed and 1500 ml of ethanol.

Further, the processing method of the external traditional Chinese medicine liquid spray comprises the following steps: taking 2-10 parts of cistanche, 2-10 parts of pseudo-ginseng, 1-10 parts of dragon's blood, 10-50 parts of borneol, 5-10 parts of sappan wood, 2-10 parts of dried alum, 2-10 parts of borax, 1-5 parts of radix pseudostellariae, 1-5 parts of cinnamon and 1-5 parts of cowherb seed, putting the raw materials into a container filled with 1000 ml of ethanol, soaking for 72 hours, and filtering to obtain liquid; adding 500 ml of ethanol into the container to soak the Chinese medicinal materials for 72 hours; then the liquid is filtered and poured out, the two liquids are combined and put into a spray bottle, and the external traditional Chinese medicine liquid spray can be obtained.

The characteristics and the effects of the Chinese herbal medicine raw materials are as follows:

(1) cistanche deserticola: [ PROPERTIES AND FLAVOURS ] WET; sweet and salty. [ GUIJING ] Kidney channel and large intestine channel. [ EFFECTIVE ] warming and recuperating kidney yang, loosening bowel to relieve constipation;

(2) pseudo-ginseng: also known as pseudo-ginseng (nature and taste) is warm; sweet and bitter. [ GUIJING ] stomach meridian and liver meridian. [ EFFECTIVE ] the functions of eliminating blood stasis, stopping bleeding, relieving swelling and alleviating pain. Can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic swelling and pain;

(3) dragon's blood: [ PROPERTIES AND FLAVOURS ] PING; sweet and salty. [ GUIJING ] Heart meridian and liver meridian. [ EFFECTIVE ACTION ] has effects of promoting blood circulation, removing blood stasis, relieving pain, stopping bleeding, promoting granulation, and healing sore. Can be used for treating traumatic injury, swelling and pain, and blood stasis and pain due to internal injury; traumatic hemorrhage, scrofula and ecthyma for a long time;

(4) borneol: [ PROPERTIES AND FLAVOUR ] is cool, pungent and bitter. [ GUIJING ] Heart and lung meridians. [ EFFECTIVE ACTION ] can induce resuscitation, refresh mind, clear heat and alleviate pain. Can be used for treating fever unconsciousness, convulsion syncope, apoplexy with phlegm syncope, qi stagnation syncope, coma, conjunctival congestion, aphtha, sore throat, and purulence in ear canal;

(5) sappan wood: [ PROPERTIES AND FLAVOURS ] PING; sweet and salty. [ GUIJING ] Heart meridian and liver meridian. [ EFFECTIVE ] can promote blood circulation, remove blood stasis, relieve swelling and alleviate pain. Can be used for treating amenorrhea, dysmenorrhea, puerperal stagnation, thoracico-abdominal pain, and traumatic swelling and pain;

(6) dried alum: [ PROPERTIES AND FLAVOURS ] COLD; is sour and astringent. [ GUIJING ] Lung, spleen, stomach and large intestine meridians. [ EFFECTIVE ACTION ] expectorant, dampness eliminating, antidiarrheal, hemostatic, toxic materials clearing away, and parasite killing. The main treatment is as follows: epilepsy, pharyngitis, acute and chronic saliva congestion, hepatitis, jaundice, yellow swelling, gastric ulcer, duodenal ulcer, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha, sore, hemorrhoid, scabies, tinea, water, fire, and insect injury;

(7) borax: [ PROPERTIES AND FLAVOUR ] cool; sweet and salty. [ GUIJING ] stomach meridian and lung meridian. [ EFFECTIVE ACTION ] can clear away heat and phlegm, remove toxic substance and prevent putrefaction. Treating sore throat, aphtha of the mouth and tongue, conjunctival congestion, nebula, choking, cough and thick phlegm;

(8) radix pseudostellariae: [ PROPERTIES AND FLAVOURS ] WET; sweet and bitter. [ GUIJING ] Lung and spleen meridians. [ EFFECTIVE ] the Chinese medicinal composition has the effects of invigorating qi, strengthening spleen, promoting the production of body fluid and moistening lung. Can be used for treating spleen deficiency, asthenia, anorexia, spontaneous perspiration, thirst, and dry cough due to lung dryness;

(9) cinnamon: [ PROPERTIES ] HEAT; pungent and bitter. [ GUIJING ] Heart channel, spleen channel, liver channel, and kidney channel. [ EFFECTIVE ACTION ] can tonify primordial qi and yang, warm spleen and stomach, remove cold accumulation, and promote blood circulation. Treating decline of vital gate fire, cold limbs and slight pulse, yang exhaustion and collapse, abdominal pain and diarrhea, cold hernia and dolphin, cold pain of waist and knee, amenorrhea, carbuncle of yin nature, multiple abscess, and floating yang deficiency, upper heat and lower cold;

(10) seed of cowherb: [ PROPERTIES AND WESTERN ] is mild and bitter. [ GUIJING ] liver meridian, stomach meridian. [ EFFECTIVE ACTION ] the medicine has the effects of promoting blood circulation, dredging channels, promoting lactation, relieving swelling, inducing diuresis and treating stranguria. Can be used for treating amenorrhea, dysmenorrhea, galactorrhea, acute mastitis, and stranguria with pain.

Has the advantages that: the external traditional Chinese medicine liquid spray for treating prostatitis, which is prepared by the invention, has the effects of resisting bacteria, diminishing inflammation, promoting blood circulation, removing blood stasis, relieving swelling and pain, can effectively treat prostatitis, has a remarkable effect, does not have toxic or side effect, is convenient to use, and is more easily accepted by consumers. The external traditional Chinese medicine liquid spray for treating prostatitis, prepared by the invention, can directly reach the focus in the form of an external liniment, and has short treatment course and quick response.

Detailed Description

The invention is illustrated below with reference to specific examples. It will be understood by those skilled in the art that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention in any way.

Example 1

An external traditional Chinese medicine liquid spray for treating male prostatitis is prepared from the following Chinese herbal medicine raw materials in parts by weight: 6 parts of cistanche, 6 parts of pseudo-ginseng, 5 parts of dragon's blood, 30 parts of borneol, 7.5 parts of sappan wood, 6 parts of dried alum, 6 parts of borax, 3 parts of radix pseudostellariae, 3 parts of cinnamon, 3 parts of cowherb seed and 1500 ml of ethanol; the processing method comprises the following steps: placing herba cistanches, radix notoginseng, dragon's blood, borneol, sappan wood, dried alum, borax, radix pseudostellariae, cinnamon and cowherb seed into a container filled with 1000 ml of ethanol, soaking for 72 hours, and then filtering out liquid; adding 500 ml of ethanol into the container to soak the Chinese medicinal materials for 72 hours; then the liquid is filtered and poured out, the two liquids are combined and put into a spray bottle, and the external traditional Chinese medicine liquid spray can be obtained.

Example 2

An external traditional Chinese medicine liquid spray for treating male prostatitis is prepared from the following Chinese herbal medicine raw materials in parts by weight: 10 parts of cistanche, 10 parts of pseudo-ginseng, 10 parts of dragon's blood, 50 parts of borneol, 10 parts of sappan wood, 10 parts of dried alum, 10 parts of borax, 5 parts of radix pseudostellariae, 5 parts of cinnamon, 5 parts of cowherb seed and 1500 ml of ethanol; the processing method comprises the following steps: placing herba cistanches, radix notoginseng, dragon's blood, borneol, sappan wood, dried alum, borax, radix pseudostellariae, cinnamon and cowherb seed into a container filled with 1000 ml of ethanol, soaking for 72 hours, and then filtering out liquid; adding 500 ml of ethanol into the container to soak the Chinese medicinal materials for 72 hours; then the liquid is filtered and poured out, the two liquids are combined and put into a spray bottle, and the external traditional Chinese medicine liquid spray can be obtained.

Example 3

An external traditional Chinese medicine liquid spray for treating male prostatitis is prepared from the following Chinese herbal medicine raw materials in parts by weight: 2 parts of cistanche, 2 parts of pseudo-ginseng, 1 part of dragon's blood, 10 parts of borneol, 5 parts of sappan wood, 2 parts of dried alum, 2 parts of borax, 1 part of radix pseudostellariae, 1 part of cinnamon, 1 part of cowherb seed and 1500 ml of ethanol; the processing method comprises the following steps: placing herba cistanches, radix notoginseng, dragon's blood, borneol, sappan wood, dried alum, borax, radix pseudostellariae, cinnamon and cowherb seed into a container filled with 1000 ml of ethanol, soaking for 72 hours, and then filtering out liquid; adding 500 ml of ethanol into the container to soak the Chinese medicinal materials for 72 hours; then the liquid is filtered and poured out, the two liquids are combined and put into a spray bottle, and the external traditional Chinese medicine liquid spray can be obtained.

Example 4

An external traditional Chinese medicine liquid spray for treating male prostatitis is prepared from the following Chinese herbal medicine raw materials in parts by weight: 8 parts of cistanche, 8 parts of pseudo-ginseng, 7 parts of dragon's blood, 40 parts of borneol, 9 parts of sappan wood, 8 parts of dried alum, 8 parts of borax, 4 parts of radix pseudostellariae, 4 parts of cinnamon, 4 parts of cowherb seed and 1500 ml of ethanol; the processing method comprises the following steps: placing herba cistanches, radix notoginseng, dragon's blood, borneol, sappan wood, dried alum, borax, radix pseudostellariae, cinnamon and cowherb seed into a container filled with 1000 ml of ethanol, soaking for 72 hours, and then filtering out liquid; adding 500 ml of ethanol into the container to soak the Chinese medicinal materials for 72 hours; then the liquid is filtered and poured out, the two liquids are combined and put into a spray bottle, and the external traditional Chinese medicine liquid spray can be obtained.

Example 5

An external traditional Chinese medicine liquid spray for treating male prostatitis is prepared from the following Chinese herbal medicine raw materials in parts by weight: 4 parts of cistanche, 4 parts of pseudo-ginseng, 3 parts of dragon's blood, 20 parts of borneol, 6 parts of sappan wood, 4 parts of dried alum, 4 parts of borax, 2 parts of radix pseudostellariae, 2 parts of cinnamon, 2 parts of cowherb seed and 1500 ml of ethanol; the processing method comprises the following steps: placing herba cistanches, radix notoginseng, dragon's blood, borneol, sappan wood, dried alum, borax, radix pseudostellariae, cinnamon and cowherb seed into a container filled with 1000 ml of ethanol, soaking for 72 hours, and then filtering out liquid; adding 500 ml of ethanol into the container to soak the Chinese medicinal materials for 72 hours; then the liquid is filtered and poured out, the two liquids are combined and put into a spray bottle, and the external traditional Chinese medicine liquid spray can be obtained.

1. Animal toxicology studies:

(1) the testing process comprises the following steps: examples 1 to 5, mice were dosed with 3-9 g/kg/day;

(2) and (4) observing results: during 180 days of continuous administration, no abnormality is found in the appearance activity of animals, no abnormality is found by visual observation after the experiment is finished, and no pathological changes related to the drugs are found by taking pathological microscopic examination of important organs (heart, liver, lung, kidney, testis, ovary and the like);

(3) and (4) conclusion: according to the weight conversion, when the mouse can tolerate 60-100 times of the dosage of the adult, the tolerance test can be accepted to be qualified, so that the drug can be considered to be safe.

2. And (3) clinical trials:

(1) general data: 255 patients, age 19-50 years, mean age 35.8 years, shortest disease course of 3 months, longest 3 years, mean 1.65 years. Patients were treated randomly into five groups using examples 1 to 5, respectively.

(2) The treatment method comprises the following steps: before the medicine is applied, the medicine-applying part is cleaned by clear water, dried and sprayed, 1-10 g of the medicine is applied each time, 1-2 times a day, and 30 days are continuously used as one treatment course, and three treatment courses are used.

(3) Standard of therapeutic effect

And (3) healing: the symptom disappears or the NIH-CPSI score is reduced by more than or equal to 95 percent, the EPS is checked normally for more than 2 times continuously, and the prostate palpation is not abnormal;

the effect is shown: the symptoms are obviously improved or NIH-CPSI is reduced by more than or equal to 60 percent, the white blood cells in EPS examination are reduced by more than or equal to 60 percent, and the tenderness and the texture of the prostate are obviously improved;

the method has the following advantages: the symptoms are improved, or NIH-CPSI is reduced by more than or equal to 30 percent, and the white blood cells in EPS examination are reduced by more than or equal to 30 percent, so that the tenderness and the texture of the prostate are slightly improved;

and (4) invalidation: no improvement in symptoms and an exacerbation or NIH-CPSI reduction < 30%, with EPS-examined leukocyte reduction < 30% or no change.

(4) Results

The results of the observation experiment using the external use traditional Chinese medicine liquid spray provided in examples 1 to 5 are shown in table 1.

TABLE 1

From the above table, it can be seen that: the external traditional Chinese medicine liquid spray provided by the embodiments 1 to 5 has the advantages that the cure rate is more than 82%, the total effective rate is more than 92%, and the effect is obvious. Meanwhile, in the clinical test period, the routine treatment of the blood and urine, the liver and kidney functions and the electrocardiogram are not abnormal. It is harmless to heart, liver and kidney. Has no obvious adverse reaction clinically.

3. Typical medical record

(1) Li in one certain age, male, 31 years old, was diagnosed in 2017 in 3-21 months for half a year due to frequent micturition, urgent micturition, and odynuria with distending pain in the lower abdomen. The patient likes to eat spicy food, has frequent micturition, urgent micturition and odynuria half a year ago, is accompanied with discomfort such as burning sensation of urethra, dripping white drops at the urethral orifice and the like, and does prostate liquid routine Examination (EPS): leukocyte + + +/HP, lecithin corpuscle +/HP. Palpation of the prostate: the prostate is slightly swollen and the tenderness is obvious. The medicine is taken orally, and urethral discomfort symptom is relieved during taking the medicine. But the disease condition recurs after stopping taking the medicine, and then the doctor visits the doctor at a later time, and uses the traditional Chinese medicine liquid spray of the invention 1-2 times a day. The symptoms of the patients are relieved during the treatment period, and the symptoms disappear after three treatment courses, so that the patients are completely cured. The follow-up visit was 2 months, and the patients did not relapse.

(2) Zhangqi, male, 47 years old, in the last month, patients often sit for a long time due to work reasons, symptoms worsen, affect daily life, and see a doctor before. The current symptoms are as follows: frequent micturition, urgent micturition, odynuria, burning sensation of urethra, occasional whitish and turbid urine at the end of urination, evident sitting, reduced pain after exercise, damp sensation in the scrotum, inappetence, yellow urine, and sticky stool. EPS: leukocyte +++/HP, lecithin corpuscle +/ HP. Palpation of the prostate: swollen prostate, hard texture, palpable nodules with marked tenderness. Both midstream urine (VB2) and prostate-massaged urine (VB3) were negative for bacterial culture. And (3) Western diagnosis: chronic nonbacterial prostatitis; traditional Chinese medicine diagnosis: seminal turbidity and damp-heat stagnation. The traditional Chinese medicine liquid spray is used for 1 to 2 times a day. And order the patient to pay attention to the diet and rest rules. After one course of treatment, the symptoms are obviously relieved, and after three courses of treatment, the symptoms disappear and are completely cured. The follow-up visit was 2 months, and the patients did not relapse.

Claims

1. An external traditional Chinese medicine liquid spray for treating male prostatitis is characterized in that: the traditional Chinese medicine composition is prepared from the following Chinese herbal medicine raw materials in parts by weight: 2-10 parts of cistanche, 2-10 parts of pseudo-ginseng, 1-10 parts of dragon's blood, 10-50 parts of borneol, 5-10 parts of sappan wood, 2-10 parts of dried alum, 2-10 parts of borax, 1-5 parts of radix pseudostellariae, 1-5 parts of cinnamon, 1-5 parts of cowherb seed and 1500 ml of ethanol.

2. The external traditional Chinese medicine liquid spray for treating prostatitis as claimed in claim 1, which is characterized in that: the traditional Chinese medicine composition is prepared from the following Chinese herbal medicine raw materials in parts by weight: 6 parts of cistanche, 6 parts of pseudo-ginseng, 5 parts of dragon's blood, 30 parts of borneol, 7.5 parts of sappan wood, 6 parts of dried alum, 6 parts of borax, 3 parts of radix pseudostellariae, 3 parts of cinnamon, 3 parts of cowherb seed and 1500 ml of ethanol.

3. The external traditional Chinese medicine liquid spray for treating prostatitis according to claim 1 or 2, which is characterized in that: the processing method comprises the following steps: taking cistanche, pseudo-ginseng, dragon's blood, borneol, sappan wood, dried alum, borax, radix pseudostellariae, cinnamon and cowherb seed according to a certain proportion, putting the mixture into a container filled with 1000 ml of ethanol, soaking for 72 hours, and then filtering out liquid; adding 500 ml of ethanol into the container to soak the Chinese medicinal materials for 72 hours; then the liquid is filtered and poured out, the two liquids are combined and put into a spray bottle, and the external traditional Chinese medicine liquid spray can be obtained.