CN105232864A - Traditional Chinese medicine clysis preparation for treating qi stagnation and blood stasis endometriosis - Google Patents
Traditional Chinese medicine clysis preparation for treating qi stagnation and blood stasis endometriosis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine clysis preparation for treating qi stagnation and blood stasis endometriosis. The traditional Chinese medicine clysis preparation is prepared from, by weight, 20 parts to 30 parts of motherwort, 15 parts to 25 parts of fructus akebiae, 10 parts to 20 parts of fructus crataegi cuneatae, 10 parts to 20 parts of caulis sargentodoxae, 5 parts to 15 parts of rhizoma cyperi, 5 parts to 15 parts of alpine yarrow herbs, 5 parts to 15 parts of selaginella tamariscina, 4 parts to 12 parts of herba lycopi, 4 parts to 12 parts of scabwort, 2 parts to 8 parts of sappanwood, 2 parts to 8 parts of stigma croci and 1 part to 5 parts of China roses. According to the traditional Chinese medicine clysis preparation, the common traditional Chinese medicinal materials are used as raw materials, the formula is scientific, and cost is low; in addition, active ingredients of the medicinal materials can directly act on the diseased portion, the effect of the medicinal materials is remarkable, side effects are avoided, the effects of promoting blood circulation to remove blood stasis, relieving dyspepsia and soothing liver-qi stagnation are achieved, and the qi stagnation and blood stasis endometriosis can be effectively treated.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of herbal enema preparation for the treatment of vital energy stagnation and blood stasis type endometriosis.
Background technology
Endometriosis is the commonly encountered diseases of Women of Childbearing Age, frequently-occurring disease and difficult treatment, in recent years, its sickness rate rises gradually, become the gynecological's second commonly encountered diseases being only second to hysteromyoma at present, this disease is the pathological changes and symptom that are caused beyond cavity of uterus by the endometrial growth with growth function, the most often betides pelvic peritoneum, also sees ovary, Rectovaginal septum, and ureter, rare in bladder, pericardium and pleura.Though gynecopathy is benign lesion, there is the local plantation of similar malignant tumor, infiltrate growth and metastasis ability.
Vital energy stagnation and blood stasis type endometriosis can be caused by internal damage by the excessive seven emotions, and its main common sympton is premenstrual inferior belly gas pain, through the play of row pain, pain draws waist sacrum, pain is very fainted, abdominal pain with tenderness, blockage of menstruation, dark through color, accompany clot, alleviation of pain under block, pelvic cavity nodosity enclosed mass, rectal tenesmus, premenstrual distending pain of the breast, uncomfortable in chestly not relax, dyspareunia, purplish tongue is dark, limit is sharp ecchymosis, white and thin fur, stringy pulse.
The medicine of current clinical treatment vital energy stagnation and blood stasis type endometriosis mainly contains Western medicine and Chinese medicine two class, and the Western medicine such as Diphereline mainly adopt hormone control therapy, but often cause the side effect such as hepar damnification, menopause, osteoporosis, and somewhat expensive; The traditional Chinese medical science adopts and dialectically to treat, and mainly with blood circulation promoting and blood stasis dispelling, to regulate the flow of vital energy soothing the liver be Therapeutic Principle.The Chinese medicine of current treatment vital energy stagnation and blood stasis type endometriosis is not also a lot, in existing patent document, application publication number CN104274774A(application number 201410488308.5) Chinese patent literature disclose a kind of Chinese medicine composition being used for the treatment of vital energy stagnation and blood stasis type endometriosis, it is characterized in that, it is be made up of the medicine of following weight: Cortex Moutan 6-12 part, Fructus Gardeniae 6-12 part, Radix Bupleuri 6-12 part, Pericarpium Citri Reticulatae Viride 6-12 part, Poria 9-15 part, Radix Angelicae Sinensis 9-15 part, Radix Paeoniae Rubra 9-15 part, Rhizoma Atractylodis Macrocephalae 6-12 part, Radix Curcumae 6-12 part, eupolyphaga 3-9 part, Semen Persicae 3-9 part, Radix Et Rhizoma Rhei 3-9 part, Ophicalcitum 9-15 part, Hirudo 3-9 part, Herba Lycopi 6-12 part, Herba Leonuri 9-15 part, every part is 1 gram.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of and prepare herbal enema preparation that is simple, that act on treatment vital energy stagnation and blood stasis type endometriosis that is rapid, evident in efficacy, that have no side effect.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is:
Treat a herbal enema preparation for vital energy stagnation and blood stasis type endometriosis, take off the raw material of Chinese medicine stating weight proportion and be prepared from: Herba Leonuri 20-30 part, Fructus Akebiae 15-25 part, Fructus Crataegi cuneatae 10-20 part, Caulis Sargentodoxae 10-20 part, Rhizoma Cyperi 5-15 part, achillea millefolium 5-15 part, Herba Selaginellae 5-15 part, Herba Lycopi 4-12 part, Radix Inulae 4-12 part, Lignum Sappan 2-8 part, Stigma Croci 2-8 part, Flos Rosae Chinensis 1-5 part.
A kind of herbal enema preparation for the treatment of vital energy stagnation and blood stasis type endometriosis, preferred scheme, takes off the raw material of Chinese medicine stating weight proportion and is prepared from: Herba Leonuri 23-27 part, Fructus Akebiae 18-22 part, Fructus Crataegi cuneatae 13-17 part, Caulis Sargentodoxae 13-17 part, Rhizoma Cyperi 8-12 part, achillea millefolium 8-12 part, Herba Selaginellae 8-12 part, Herba Lycopi 6-10 part, Radix Inulae 6-10 part, Lignum Sappan 4-6 part, Stigma Croci 4-6 part, Flos Rosae Chinensis 2-4 part.
A kind of herbal enema preparation for the treatment of vital energy stagnation and blood stasis type endometriosis, preferred scheme, takes off the raw material of Chinese medicine stating weight proportion and is prepared from: Herba Leonuri 25 parts, Fructus Akebiae 20 parts, Fructus Crataegi cuneatae 15 parts, Caulis Sargentodoxae 15 parts, Rhizoma Cyperi 10 parts, achillea millefolium 10 parts, Herba Selaginellae 10 parts, Herba Lycopi 8 parts, Radix Inulae 8 parts, Lignum Sappan 5 parts, Stigma Croci 5 parts, Flos Rosae Chinensis 3 parts.
The preparation method of the herbal enema preparation of above-mentioned treatment vital energy stagnation and blood stasis type endometriosis, step is as follows:
Step one: after Caulis Sargentodoxae, Rhizoma Cyperi being cleaned up, cutting into slices, add raw material weight 0.1-0.3 yellow wine doubly and mix thoroughly, moistening, to thoroughly, is then put slow fire fried dry in pot, is ground into 80-120 object fine powder;
Step 2: Herba Leonuri, achillea millefolium, Herba Lycopi, Radix Inulae, Stigma Croci, Flos Rosae Chinensis are cleaned up respectively, shred, add the water soaking 20-40min of raw material weight 5-15 times 15-25 DEG C, then place it in distilling flask, reflux 1-3h under 70-90 DEG C of condition, collects and obtains volatile oil;
Step 3: after Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Lignum Sappan are cleaned up, cutting into slices, be placed in marmite, add the water soaking 30-50 minute of raw material weight 3-7 times 15-25 DEG C, then decoct with high heat to boiling, use slow fire instead to continue to decoct 10-30min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 2-4 times 15-25 DEG C, intense fire decocts to boiling, slow fire continues to decoct 5-15min, filters, obtains secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the volatile oil that fine powder step one obtained and step 2 obtain joins in the filtrate of step 3, stirs, under 80 DEG C of conditions after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtains herbal enema preparation of the present invention.
The preparation method of the herbal enema preparation of above-mentioned treatment vital energy stagnation and blood stasis type endometriosis, step one adds raw material weight 0.15-0.25 yellow wine doubly and mixes thoroughly, and moistening, to thoroughly, is then put slow fire fried dry in pot, after cooling, is ground into 90-110 object fine powder; Preferably, the yellow wine adding raw material weight 0.2 times is mixed thoroughly, slow fire fried dry, is ground into 100 object fine powders.
The preparation method of the herbal enema preparation of above-mentioned treatment vital energy stagnation and blood stasis type endometriosis, step 2 adds the water soaking 25-35min of raw material weight 8-12 times 18-22 DEG C, then place it in distilling flask, reflux 1.5-2.5h under 75-85 DEG C of condition, collect and obtain volatile oil; Preferably, add the water soaking 30min of raw material weight 10 times 20 DEG C, then place it in distilling flask, reflux 2h under 80 DEG C of conditions, collect and obtain volatile oil.
The preparation method of the herbal enema preparation of above-mentioned treatment vital energy stagnation and blood stasis type endometriosis, the water soaking 35-45 minute that step Acanthopanan trifoliatus (L.) Merr. raw material weight is 4-6 times 18-22 DEG C, then decocts to boiling with high heat, uses slow fire instead and continues to decoct 15-25min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 2.5-3.5 times 18-22 DEG C, intense fire decocts to boiling, slow fire continues to decoct 8-12min, filters, obtains secondary decocting liquid; Preferably, add the water soaking 40 minutes of raw material weight 5 times 20 DEG C, then decoct to boiling with high heat, use slow fire instead and continue to decoct 20min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 3 times 20 DEG C, intense fire decocts to boiling, slow fire continues to decoct 10min, filters, obtains secondary decocting liquid.
The using method of the herbal enema preparation of above-mentioned treatment vital energy stagnation and blood stasis type endometriosis: be placed on before use in water and be heated to about 35 DEG C, then with the speed retention enema that enemator drips with 20-30 per minute, every day 1 time, each 100mL.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Leonuri: cold nature, bitter in the mouth, pungent.Return Liver Channel, heart channel, urinary bladder channel.Effect and effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.With controlling the dysmenorrhea of women's blood stasis, amenorrhea, blockage of menstruation, postpartum stagnation stomachache; Edema, dysuria etc.
Fructus Akebiae: cold in nature, bitter in the mouth.Return Liver Channel, gallbladder meridian, stomach warp, urinary bladder channel.Effect and effect: depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Food, lumbago, hypochondriac pain, hernia, dysmenorrhea, uterine prolapse, excessive thirst, ureteral calculus is not thought by treating the liver peratodynia, gastric heat.
Fructus Crataegi cuneatae: slightly warm in nature, sour in the mouth, sweet.Return spleen channel, stomach warp, Liver Channel.Effect and effect: removing food stagnancyization is stagnant, dispelling the stagnated QI dissipating blood stasis.For meat stagnation, children's's infantile dyspepsia, abdominal distention, dysentery, has loose bowels, dysmenorrhea, and postnatal blood stasis is suffered from abdominal pain, hernia, hyperlipidemia.
Caulis Sargentodoxae: property is put down, bitter in the mouth.Return large intestine channel, Liver Channel.Effect and effect: heat-clearing and toxic substances removing, promoting blood circulation by removing wind, pain relieving.With controlling abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, tumbling and swelling.
Rhizoma Cyperi: property is put down, acrid in the mouth, micro-hardship, micro-sweet.Return Liver Channel, spleen channel, tri-jiao channel.Effect and effect: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.With treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses etc.
Achillea millefolium: property is put down, sour in the mouth, hardship.Return lung meridian, spleen channel, urinary bladder channel.Effect and effect: heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow.Clinically be used for amenorrhea stomachache, acute enteritis, appendicitis, tonsillitis, mastitis, traumatic injury and venom etc.
Herba Selaginellae: property is put down, acrid in the mouth.Return Liver Channel, heart channel.Effect and effect: blood circulation promoting and blood stasis dispelling, hemostasis.For women's amenorrhea, dysmenorrhea, leprosy abdominal mass, gastral cavity abdomen stasis of blood pain, traumatic injury, congestive edema, multiple hemorrhage, burn due to hot liquid or fire.
Herba Lycopi: slightly warm in nature, bitter in the mouth.Return Liver Channel, spleen channel.Effect and effect: promoting the circulation of blood diuresis, loose strongly fragrant soothing liver-QI.Swell and ache for menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis abdomen pain, body and face edema, traumatic injury, skin infection.
Radix Inulae: warm in nature, acrid in the mouth, hardship.Return Liver Channel, spleen channel.Effect and effect: invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, pain relieving are antiabortive.The treatment breast side of body, abdominal distention, vomiting dysentery, the contusion of the breast side of body, feel a pain in the chest when breathing have a pain, frequent fetal movement.
Lignum Sappan: property is put down, sweet in the mouth, salty.GUIXIN warp, Liver Channel, spleen channel.Effect and effect: promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.With controlling traumatic injury, the fracture injury of tendon and muscle, the stasis of blood is stagnant to swell and ache, amenorrhea dysmenorrhea, postpartum stagnation, breast ventral spine pain, ulcer sore pain.
Stigma Croci: the property of medicine: sweet is flat.GUIXIN, Liver Channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, and dissipating blood stasis unwinds.Cure mainly dysmenorrhea, amenorrhea, menoxenia, post partum longtime lochia, enclosed mass pain in abdomen, injury from falling down, melancholy painful abdominal mass is vexed, and palpitation with fear, epidemic febrile disease sends out speckle, measles.
Flos Rosae Chinensis: warm in nature, sweet in the mouth.Return Liver Channel.Effect and effect: promoting blood flow to regulate menstruation, dispersing the stagnated live-QI to relieve the stagnation of QI.The menoxenia caused with controlling depression of liver-QI, dysmenorrhea, amenorrhea, chest and abdomen swelling and pain, traumatic injury, blood stasis are swollen and ache, swollen ulcer drug and scrofula etc.
With prior art ratio, beneficial effect of the present invention is:
The present invention treats the herbal enema preparation of vital energy stagnation and blood stasis type endometriosis, adopt common Chinese medicine material as raw material, scientific formulation, with low cost, and adopt enema agent, make active constituents of medicine to directly act on diseased region, drug effect is remarkable, have no side effect, have that blood circulation promoting and blood stasis dispelling, removing food stagnancyization are stagnant, effect of dispersing the stagnated live-QI to relieve the stagnation of QI, effectively can treat vital energy stagnation and blood stasis type endometriosis.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat a herbal enema preparation for vital energy stagnation and blood stasis type endometriosis, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): Herba Leonuri 20 parts, Fructus Akebiae 15 parts, Fructus Crataegi cuneatae 10 parts, Caulis Sargentodoxae 10 parts, Rhizoma Cyperi 5 parts, achillea millefolium 5 parts, Herba Selaginellae 5 parts, Herba Lycopi 4 parts, Radix Inulae 4 parts, Lignum Sappan 2 parts, Stigma Croci 2 parts, Flos Rosae Chinensis 1 part.
The preparation method of the herbal enema preparation of above-mentioned treatment vital energy stagnation and blood stasis type endometriosis, step is as follows:
Step one: after Caulis Sargentodoxae, Rhizoma Cyperi being cleaned up, cutting into slices, the yellow wine adding raw material weight 0.1 times is mixed thoroughly, and moistening, to thoroughly, is then put slow fire fried dry in pot, is ground into 80 object fine powders;
Step 2: Herba Leonuri, achillea millefolium, Herba Lycopi, Radix Inulae, Stigma Croci, Flos Rosae Chinensis are cleaned up respectively, shred, add the water soaking 20min of raw material weight 5 times 15 DEG C, then place it in distilling flask, reflux 1h under 70 DEG C of conditions, collect and obtain volatile oil;
Step 3: after Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Lignum Sappan being cleaned up, cutting into slices, be placed in marmite, adds the water soaking 30 minutes of raw material weight 3 times 15 DEG C, then decoct to boiling with high heat, use slow fire instead and continue to decoct 10min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 2 times 15 DEG C, intense fire decocts to boiling, slow fire continues to decoct 5min, filters, obtains secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the volatile oil that fine powder step one obtained and step 2 obtain joins in the filtrate of step 3, stirs, under 80 DEG C of conditions after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtains herbal enema preparation of the present invention.
model case one:open xx, female, 28 years old, people from Jinan, patient per's menstrual onset lower abdomen pain, aggravation in nearly 2 years, blockage of menstruation, dark through color, accompany clot, gynaecological examination: pudendum, vagina no abnormality seen, cervix uteri: slightly rotten to the corn, Gong Ti: rear position, matter is soft, activity is poor, adnexa: a cystic enclosed mass is touched in left side; Purplish tongue is dark, limit is sharp has ecchymosis, white and thin fur, stringy pulse.Be diagnosed as the endometriosis that qi depression to blood stasis causes, give the herbal enema preparation for treating in its embodiment of the present invention 1.
Treat after 1 month, abdominal pain in menstruation alleviates, the eumenorrhea, and clot disappears, and continual cure is after 1 month, and ultrasound diagnosis left side attachment enclosed mass disappears, recovery from illness.
embodiment 2treat a herbal enema preparation for vital energy stagnation and blood stasis type endometriosis, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): Herba Leonuri 30 parts, Fructus Akebiae 25 parts, Fructus Crataegi cuneatae 20 parts, Caulis Sargentodoxae 20 parts, Rhizoma Cyperi 15 parts, achillea millefolium 15 parts, Herba Selaginellae 15 parts, Herba Lycopi 12 parts, Radix Inulae 12 parts, Lignum Sappan 8 parts, Stigma Croci 8 parts, Flos Rosae Chinensis 5 parts.
The preparation method of the herbal enema preparation of above-mentioned treatment vital energy stagnation and blood stasis type endometriosis, step is as follows:
Step one: after Caulis Sargentodoxae, Rhizoma Cyperi being cleaned up, cutting into slices, the yellow wine adding raw material weight 0.3 times is mixed thoroughly, and moistening, to thoroughly, is then put slow fire fried dry in pot, is ground into 120 object fine powders;
Step 2: Herba Leonuri, achillea millefolium, Herba Lycopi, Radix Inulae, Stigma Croci, Flos Rosae Chinensis are cleaned up respectively, shred, add the water soaking 40min of raw material weight 15 times 25 DEG C, then place it in distilling flask, reflux 3h under 90 DEG C of conditions, collect and obtain volatile oil;
Step 3: after Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Lignum Sappan being cleaned up, cutting into slices, be placed in marmite, adds the water soaking 50 minutes of raw material weight 7 times 25 DEG C, then decoct to boiling with high heat, use slow fire instead and continue to decoct 30min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 4 times 25 DEG C, intense fire decocts to boiling, slow fire continues to decoct 15min, filters, obtains secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the volatile oil that fine powder step one obtained and step 2 obtain joins in the filtrate of step 3, stirs, under 80 DEG C of conditions after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtains herbal enema preparation of the present invention.
embodiment 3treat a herbal enema preparation for vital energy stagnation and blood stasis type endometriosis, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): Herba Leonuri 23 parts, Fructus Akebiae 18 parts, Fructus Crataegi cuneatae 13 parts, Caulis Sargentodoxae 13 parts, Rhizoma Cyperi 8 parts, achillea millefolium 8 parts, Herba Selaginellae 8 parts, Herba Lycopi 6 parts, Radix Inulae 6 parts, Lignum Sappan 4 parts, Stigma Croci 4 parts, Flos Rosae Chinensis 2 parts.
The preparation method of the herbal enema preparation of above-mentioned treatment vital energy stagnation and blood stasis type endometriosis, step is as follows:
Step one: after Caulis Sargentodoxae, Rhizoma Cyperi being cleaned up, cutting into slices, the yellow wine adding raw material weight 0.15 times is mixed thoroughly, and moistening, to thoroughly, is then put slow fire fried dry in pot, is ground into 90 object fine powders;
Step 2: Herba Leonuri, achillea millefolium, Herba Lycopi, Radix Inulae, Stigma Croci, Flos Rosae Chinensis are cleaned up respectively, shred, add raw material weight 8 times 18 DEG C water soaking 25min, then place it in distilling flask, reflux 1.5h under 75 DEG C of conditions, collect and obtain volatile oil;
Step 3: after Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Lignum Sappan being cleaned up, cutting into slices, be placed in marmite, adds the water soaking 35 minutes of raw material weight 4 times 18 DEG C, then decoct to boiling with high heat, use slow fire instead and continue to decoct 15min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 2.5 times 18 DEG C, intense fire decocts to boiling, slow fire continues to decoct 8min, filters, obtains secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the volatile oil that fine powder step one obtained and step 2 are collected joins in the filtrate of step 3, stirs, under 80 DEG C of conditions after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtains herbal enema preparation of the present invention.
model case two:liu xx, female, 32 years old, people from Jinan, distending pain of the breast before patient per's menstrual onset, did not uncomfortable in chestly relax, and dyspareunia, infertile, gynaecological examination pudendum is married formula.Vagina is smooth.Cervix uteri is smooth, lifts the pain positive.Position after the body of palace, mobility is not good enough.Ride side attachment district can touch enclosed mass, and tenderness is positive, and purplish tongue is dark, limit is sharp has ecchymosis, white and thin fur, stringy pulse.Be diagnosed as the endometriosis that qi depression to blood stasis causes.
Herbal enema preparation for treating in the employing embodiment of the present invention 3 is after 1 month, and ultrasound diagnosis ride side attachment enclosed mass disappears, and abdominal pain in menstruation alleviates, and continual cure is after 1 month, and malaise symptoms obviously improves, and pays a return visit after 1 year, and patient body is healthy, and conceived.
embodiment 4treat a herbal enema preparation for vital energy stagnation and blood stasis type endometriosis, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): Herba Leonuri 27 parts, Fructus Akebiae 22 parts, Fructus Crataegi cuneatae 17 parts, Caulis Sargentodoxae 17 parts, Rhizoma Cyperi 12 parts, achillea millefolium 12 parts, Herba Selaginellae 12 parts, Herba Lycopi 10 parts, Radix Inulae 10 parts, Lignum Sappan 6 parts, Stigma Croci 6 parts, Flos Rosae Chinensis 4 parts.
The preparation method of the herbal enema preparation of above-mentioned treatment vital energy stagnation and blood stasis type endometriosis, step is as follows:
Step one: after Caulis Sargentodoxae, Rhizoma Cyperi being cleaned up, cutting into slices, the yellow wine adding raw material weight 0.25 times is mixed thoroughly, and moistening, to thoroughly, is then put slow fire fried dry in pot, is ground into 110 object fine powders;
Step 2: Herba Leonuri, achillea millefolium, Herba Lycopi, Radix Inulae, Stigma Croci, Flos Rosae Chinensis are cleaned up respectively, shred, add the water soaking 35min of raw material weight 12 times 22 DEG C, then place it in distilling flask, reflux 2.5h under 85 DEG C of conditions, collect and obtain volatile oil;
Step 3: after Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Lignum Sappan being cleaned up, cutting into slices, be placed in marmite, adds the water soaking 45 minutes of raw material weight 6 times 22 DEG C, then decoct to boiling with high heat, use slow fire instead and continue to decoct 25min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 3.5 times 22 DEG C, intense fire decocts to boiling, slow fire continues to decoct 12min, filters, obtains secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the volatile oil that fine powder step one obtained and step 2 obtain joins in the filtrate of step 3, stirs, under 80 DEG C of conditions after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtains herbal enema preparation of the present invention.
embodiment 5treat a herbal enema preparation for vital energy stagnation and blood stasis type endometriosis, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): Herba Leonuri 25 parts, Fructus Akebiae 20 parts, Fructus Crataegi cuneatae 15 parts, Caulis Sargentodoxae 15 parts, Rhizoma Cyperi 10 parts, achillea millefolium 10 parts, Herba Selaginellae 10 parts, Herba Lycopi 8 parts, Radix Inulae 8 parts, Lignum Sappan 5 parts, Stigma Croci 5 parts, Flos Rosae Chinensis 3 parts.
The preparation method of the herbal enema preparation of above-mentioned treatment vital energy stagnation and blood stasis type endometriosis, step is as follows:
Step one: after Caulis Sargentodoxae, Rhizoma Cyperi being cleaned up, cutting into slices, the yellow wine adding raw material weight 0.2 times is mixed thoroughly, and moistening, to thoroughly, is then put slow fire fried dry in pot, is ground into 100 object fine powders;
Step 2: Herba Leonuri, achillea millefolium, Herba Lycopi, Radix Inulae, Stigma Croci, Flos Rosae Chinensis are cleaned up respectively, shred, add raw material weight 10 times 20 DEG C water soaking 30min, then place it in distilling flask, reflux 2h under 80 DEG C of conditions, collect and obtain volatile oil;
Step 3: after Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Lignum Sappan being cleaned up, cutting into slices, be placed in marmite, adds the water soaking 40 minutes of raw material weight 5 times 20 DEG C, then decoct to boiling with high heat, use slow fire instead and continue to decoct 20min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 3 times 20 DEG C, intense fire decocts to boiling, slow fire continues to decoct 10min, filters, obtains secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the volatile oil that fine powder step one obtained and step 2 obtain joins in the filtrate of step 3, stirs, under 80 DEG C of conditions after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtains herbal enema preparation of the present invention.
experimental example:1, selection of clinical: in order to verify that the present invention treats the effect of the herbal enema preparation of vital energy stagnation and blood stasis type endometriosis, we have extracted 200 patients and have carried out the experiment of medicine, be equally divided into two groups, experimental group and matched group, two groups in age, sex, clinical manifestation etc. through statistical analysis there was no significant difference.
2, diagnostic criteria: " Chinese medical disease Standardization of diagnosis and curative effect " that diagnosis basis State Administration of Traditional Chinese Medicine issues: 1. Progressive symmetric erythrokeratodermia dysmenorrhea; 2. menstrual period lower abdominal pain, the uncomfortable and Progressive symmetric erythrokeratodermia aggravation of lumbosacral region; 3. periodicity rectal distention stimulation symptom; 4. posterior fornix jarjavay's ligaments or isthmus uteri touch painful tubercles; 5. adnexal adhesions, enclosed mass, tuberosity sense; Before and after menstruation, adnexal masses has obvious size variation.All have one of 6. one of 3. 1. 2. add and 4. 5. can be diagnosed as this disease.
3, Therapeutic Method:
Experimental group: treatment vital energy stagnation and blood stasis type endometriosis herbal enema preparation, every day 100mL.
Matched group: oral danazol, every day 2 times, each 200mg.
4, curative effect situation criterion: effectively: after treatment, dysmenorrhea, menstrual period the malaise symptoms such as lower abdominal pain alleviate or partial disappearance.Invalid: after treatment, malaise symptoms is unchanged.Accurately the data of two groups of experiments are added up and mathematical analysis, obtain specific experiment result as following table:
Table 1:
Table 2:
Prove through clinical trial, the effective percentage of herbal enema preparation for treating vital energy stagnation and blood stasis type endometriosis of the present invention is 98%, compared with the effect for the treatment of this disease with oral western medicine danazol, there is scientific formulation, with low cost, drug effect is remarkable, has no side effect, the advantage of drug safety, effectively can treat vital energy stagnation and blood stasis type endometriosis.
Claims (10)
1. treat a herbal enema preparation for vital energy stagnation and blood stasis type endometriosis, it is characterized in that: take off the raw material of Chinese medicine stating weight proportion and be prepared from: Herba Leonuri 20-30 part, Fructus Akebiae 15-25 part, Fructus Crataegi cuneatae 10-20 part, Caulis Sargentodoxae 10-20 part, Rhizoma Cyperi 5-15 part, achillea millefolium 5-15 part, Herba Selaginellae 5-15 part, Herba Lycopi 4-12 part, Radix Inulae 4-12 part, Lignum Sappan 2-8 part, Stigma Croci 2-8 part, Flos Rosae Chinensis 1-5 part.
2. a kind of herbal enema preparation for the treatment of vital energy stagnation and blood stasis type endometriosis according to claim 1, is characterized in that: take off the raw material of Chinese medicine stating weight proportion and be prepared from: Herba Leonuri 23-27 part, Fructus Akebiae 18-22 part, Fructus Crataegi cuneatae 13-17 part, Caulis Sargentodoxae 13-17 part, Rhizoma Cyperi 8-12 part, achillea millefolium 8-12 part, Herba Selaginellae 8-12 part, Herba Lycopi 6-10 part, Radix Inulae 6-10 part, Lignum Sappan 4-6 part, Stigma Croci 4-6 part, Flos Rosae Chinensis 2-4 part.
3. a kind of herbal enema preparation for the treatment of vital energy stagnation and blood stasis type endometriosis according to claim 1, is characterized in that: take off the raw material of Chinese medicine stating weight proportion and be prepared from: Herba Leonuri 25 parts, Fructus Akebiae 20 parts, Fructus Crataegi cuneatae 15 parts, Caulis Sargentodoxae 15 parts, Rhizoma Cyperi 10 parts, achillea millefolium 10 parts, Herba Selaginellae 10 parts, Herba Lycopi 8 parts, Radix Inulae 8 parts, Lignum Sappan 5 parts, Stigma Croci 5 parts, Flos Rosae Chinensis 3 parts.
4. a preparation method for the herbal enema preparation of the treatment vital energy stagnation and blood stasis type endometriosis according to any one of claim 1-3, is characterized in that: step is as follows:
Step one: after Caulis Sargentodoxae, Rhizoma Cyperi being cleaned up, cutting into slices, add raw material weight 0.1-0.3 yellow wine doubly and mix thoroughly, moistening, to thoroughly, is then put slow fire fried dry in pot, is ground into 80-120 object fine powder;
Step 2: Herba Leonuri, achillea millefolium, Herba Lycopi, Radix Inulae, Stigma Croci, Flos Rosae Chinensis are cleaned up respectively, shred, add the water soaking 20-40min of raw material weight 5-15 times 15-25 DEG C, then place it in distilling flask, reflux 1-3h under 70-90 DEG C of condition, collects and obtains volatile oil;
Step 3: after Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Lignum Sappan are cleaned up, cutting into slices, be placed in marmite, add the water soaking 30-50 minute of raw material weight 3-7 times 15-25 DEG C, then decoct with high heat to boiling, use slow fire instead to continue to decoct 10-30min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 2-4 times 15-25 DEG C, intense fire decocts to boiling, slow fire continues to decoct 5-15min, filters, obtains secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the volatile oil that fine powder step one obtained and step 2 obtain joins in the filtrate of step 3, stirs, under 80 DEG C of conditions after high temperature sterilize 10min, by its pressure bottle fill, aluminium lid pressurization seal, obtains herbal enema preparation of the present invention.
5. a kind of preparation method for the treatment of the herbal enema preparation of vital energy stagnation and blood stasis type endometriosis according to claim 4, it is characterized in that: step one adds raw material weight 0.15-0.25 yellow wine doubly and mixes thoroughly, moistening is to saturating, then put slow fire fried dry in pot, be ground into 90-110 object fine powder.
6. a kind of preparation method for the treatment of the herbal enema preparation of vital energy stagnation and blood stasis type endometriosis according to claim 5, is characterized in that: the yellow wine that step one adds raw material weight 0.2 times is mixed thoroughly, slow fire fried dry, is ground into 100 object fine powders.
7. a kind of preparation method for the treatment of the herbal enema preparation of vital energy stagnation and blood stasis type endometriosis according to claim 4, it is characterized in that: step 2 adds the water soaking 25-35min of raw material weight 8-12 times 18-22 DEG C, then place it in distilling flask, reflux 1.5-2.5h under 75-85 DEG C of condition, collects and obtains volatile oil.
8. a kind of preparation method for the treatment of the herbal enema preparation of vital energy stagnation and blood stasis type endometriosis according to claim 7, it is characterized in that: step 2 adds the water soaking 30min of raw material weight 10 times 20 DEG C, then place it in distilling flask, reflux 2h under 80 DEG C of conditions, collects and obtains volatile oil.
9. a kind of preparation method for the treatment of the herbal enema preparation of vital energy stagnation and blood stasis type endometriosis according to claim 4, it is characterized in that: the water soaking 35-45 minute that step Acanthopanan trifoliatus (L.) Merr. raw material weight is 4-6 times 18-22 DEG C, then decoct with high heat to boiling, use slow fire instead to continue to decoct 15-25min, filter, leach medicinal residues, obtain decocting liquid first, then in filtering residue, add the water of raw material weight 2.5-3.5 times 18-22 DEG C, intense fire decocts to boiling, slow fire continues to decoct 8-12min, filters, obtains secondary decocting liquid.
10. a kind of preparation method for the treatment of the herbal enema preparation of vital energy stagnation and blood stasis type endometriosis according to claim 9, it is characterized in that: the water soaking that step Acanthopanan trifoliatus (L.) Merr. raw material weight is 5 times 20 DEG C 40 minutes, then decoct to boiling with high heat, use slow fire instead and continue to decoct 20min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 3 times 20 DEG C, intense fire decocts to boiling, slow fire continues to decoct 10min, filters, obtains secondary decocting liquid.
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