CN110624063A - Formula for treating liver and gallbladder damp-heat type thirst disease and preparation method thereof - Google Patents
Formula for treating liver and gallbladder damp-heat type thirst disease and preparation method thereof Download PDFInfo
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Abstract
The invention provides a treatment formula of liver and gallbladder damp-heat type thirst disease and a preparation method thereof. The treatment formula for liver and gallbladder damp-heat type thirst disease comprises the following raw materials in parts by weight: 20-30 g of gentian, 28-35 g of radix bupleuri, 18-22 g of plantain, 21-28 g of coix seed, 28-35 g of cyclocarya paliurus, 13-19 g of white peony root and 18-23 g of chrysanthemum. The raw materials of the medicinal materials of the formula for treating liver and gallbladder damp-heat type thirst disease and the preparation method thereof belong to common traditional Chinese medicinal materials, so the raw materials are convenient to obtain, the preparation method is simple, the decoction can be decocted by self, the operation of preparing the liquid medicine is simple, and the prepared liquid medicine can be directly taken orally; the formula of the traditional Chinese medicine composition not only comprises cyclocarya paliurus for treating diabetes, but also comprises gentian, radix bupleuri, plantain, coix seed, radix paeoniae alba and chrysanthemum for treating and protecting gallbladder, liver and spleen, so that the traditional Chinese medicine composition can reduce blood sugar and blood pressure of patients suffering from liver and gallbladder dampness-heat type diabetes, can clear heat, promote diuresis, soothe liver and promote bile flow, and is suitable for treating patients suffering from liver and gallbladder dampness-heat type diabetes.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine treatment formulas for diabetes, and particularly relates to a treatment formula for liver and gallbladder damp-heat type diabetes and a preparation method thereof.
Background
Diabetes usually occurs in middle-aged and people who like thick paste, wine, but some teenagers suffer from the disease. Clinically, the deficiency of yin fluid and the generation of dryness-heat are the basic pathogenesis of diabetes. The name of diabetes is first reported in Nei Jing, Ling Shu & Wu Shi, a "Wen Bing Dan for the weak five zang organs, Bing Xiao", which indicates that the weak five zang organs is an important factor for the occurrence of diabetes. The research and development of the medicine for preventing and treating the diabetes have very important significance, and the social benefit and the economic benefit are huge.
Diabetes mellitus is diabetes mellitus in western medicine, namely insulin deficiency in western medicine, and the basic pathology is metabolic disorder of sugar, protein, fat, water, electrolyte and the like caused by absolute or relative insulin secretion deficiency and glucagon activity increase. The traditional Chinese medicine belongs to the category of diabetes, the pathogenesis of the diabetes is closely related to the three organs of lung, spleen and kidney, the pathogenesis of the diabetes is mainly yin deficiency and dryness-heat, qi and yin loss, and the clinically seen non-insulin-dependent type that middle-aged and old people can not cure for a long time is mainly qi and yin deficiency. Although they are treated by type division, the zang-fu organs are usually related to each other in syndrome differentiation, such as deficiency of both qi and yin, the location of disease is in the lung, and it is seen in the kidney or lung-kidney.
In recent years, the traditional Chinese medicine has better curative effect on improving the symptoms of diabetes, preventing and treating complications and the like, however, the existing traditional Chinese medicine formula does not perform targeted treatment on diabetes of different pathogenesis, the types of diabetes at present mainly include type A (yin deficiency and dryness heat type appearing in type II diabetes), type B (qi and yin deficiency type appearing in type II diabetes), type C (blood stasis and collateral obstruction type appearing in type II diabetes), type D (dryness heat and lung injury type appearing in type II diabetes), type F (skin itch appearing in type II diabetes) and the like, but the medicinal materials selected in the current treatment process are universal medicinal materials and only treat the people suffering from the disease, the patients with various disease states caused by the disease are not particularly specified, deep knowledge on diabetes of different disease types is lacked, and corresponding traditional Chinese medicinal materials are not selected for targeted treatment, so the curative effect of the treatment is influenced to a certain extent.
Among them, damp-heat in the liver and gallbladder is a disease caused by the malfunction of liver and gallbladder with damp-heat in the interior. It is usually caused by the affection of damp-heat or the endogenous dampness due to spleen deficiency, which can lead to the transformation of heat over time, or the long-term overeating of sweet, fat and thick flavor to generate dampness and help heat, which can affect the function of liver and gallbladder. The disease belongs to the excess syndrome, the viscera are diseased simultaneously, the disease is located in the liver and the gallbladder, and the spleen and the stomach are often involved, so when treating, patients with diabetes of the liver and gallbladder damp-heat type need to carry out protective treatment on the liver and the gallbladder of the patients, otherwise, the treatment effect is influenced, but the current treatment of diabetes mainly comprises diabetes pills, and the traditional Chinese medicine has no curative effect on the liver and the gallbladder of the patients, and has weak pertinence, so the curative effect is low.
Therefore, there is a need to provide a formula for treating thirst due to damp-heat in liver and gallbladder and a preparation method thereof to solve the above technical problems.
Disclosure of Invention
The invention provides a treatment formula of liver and gallbladder damp-heat type thirst disease and a preparation method thereof, and solves the problems.
In order to solve the technical problems, the invention provides a treatment formula for liver and gallbladder damp-heat type thirst disease, which comprises the following raw materials in parts by weight: 20-30 g of gentian, 28-35 g of radix bupleuri, 18-22 g of plantain, 21-28 g of coix seed, 28-35 g of cyclocarya paliurus, 13-19 g of white peony root and 18-23 g of chrysanthemum.
Preferably, the feed comprises the following raw materials in parts by weight: 25 g of gentian, 30 g of radix bupleuri, 20 g of plantain, 25 g of semen coicis, 30 g of cyclocarya paliurus, 15 g of white paeony root and 20 g of chrysanthemum.
A preparation method of a formula for treating liver and gallbladder damp-heat type thirst disease comprises the following steps:
(1) taking gentian, radix bupleuri, plantain, coix seed, cyclocarya paliurus, white paeony root and chrysanthemum according to parts by weight;
(2) putting felwort, radix bupleuri, plantain, cyclocarya paliurus, radix paeoniae alba and chrysanthemum into a marmite, then adding water with the weight 4 times that of the medicines into the marmite, and decocting the mixture for 30min by using slow fire;
(3) putting the coix seeds into a frying pan, frying the coix seeds to be yellow by strong fire, taking out the coix seeds, and cooling the coix seeds for later use;
(4) putting the fried-yellow coix seeds into a marmite, and decocting for 15min by using slow fire;
(5) taking out the decocted liquid medicine and putting the liquid medicine into a medicine pot;
(6) adding water into the casserole again, decocting with strong fire until the casserole is boiled, then decocting with slow fire for 10min, taking out the liquid medicine, and putting into a medicine tank;
(7) repeating the steps twice, and mixing the three decocted medicinal soups together;
(8) and the obtained decoction is taken orally for three times.
Preferably, in the step (6), the water is added according to the condition that the water level is higher than the medicine level by one centimeter.
Preferably, the three decoctions are placed in different pots respectively, and finally mixed together.
In the invention, the properties, the taste, the meridian tropism and the efficacy of each raw material are as follows:
gentian: bitter taste and cold nature; entering lung and liver meridians; clearing heat and drying dampness, and purging liver and gallbladder fire;
bupleurum root: bitter, pungent and slightly cold; it enters liver and gallbladder meridians; relieving exterior syndrome, relieving fever, dispersing stagnated liver qi, and invigorating yang qi;
plantain herb: sweet and cold in nature; it enters liver, kidney and bladder meridians; clearing away heat, promoting urination, cooling blood, and removing toxic substances;
coix seed: sweet and cool in nature; spleen, stomach, lung meridian entered; promoting diuresis, eliminating dampness, invigorating spleen, relieving diarrhea, removing arthralgia, expelling pus, removing toxic substance, and resolving hard mass;
cyclocarya paliurus: slightly bitter and warm in nature; unknown; clearing heat and relieving swelling;
white peony root: bitter and sour, slightly cold in nature; entering liver and spleen meridians; nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain, and suppressing liver yang;
chrysanthemum: pungent, sweet and bitter; entering lung and liver meridians; disperse wind-heat, calm liver yang, clear liver heat and improve vision, clear heat and remove toxicity.
Compared with the related technology, the treatment formula of liver and gallbladder damp-heat type thirst disease and the preparation method thereof provided by the invention have the following beneficial effects:
the invention provides a treatment formula for liver and gallbladder damp-heat type thirst and a preparation method thereof, wherein the raw materials of medicinal materials belong to common Chinese medicinal materials, so that the raw materials are convenient to obtain, the preparation method is simple, the raw materials can be decocted by self, the operation of preparing liquid medicine is simple, and the prepared liquid medicine can be directly taken orally; the formula of the traditional Chinese medicine composition not only comprises cyclocarya paliurus for treating diabetes, but also comprises gentian, radix bupleuri, plantain, coix seed, radix paeoniae alba and chrysanthemum for treating and protecting gallbladder, liver and spleen, so that the traditional Chinese medicine composition can reduce blood sugar and blood pressure of patients suffering from liver and gallbladder dampness-heat type diabetes, can clear heat, promote diuresis, soothe liver and promote bile flow, and is suitable for treating patients suffering from liver and gallbladder dampness-heat type diabetes.
Detailed Description
The present invention will be further described with reference to the following embodiments.
A treatment formula for liver and gallbladder damp-heat type thirst disease comprises the following raw materials in parts by weight: 25 g of gentian, 30 g of radix bupleuri, 20 g of plantain, 25 g of semen coicis, 30 g of cyclocarya paliurus, 15 g of white paeony root and 20 g of chrysanthemum.
A preparation method of a formula for treating liver and gallbladder damp-heat type thirst disease comprises the following steps:
(1) taking gentian, radix bupleuri, plantain, coix seed, cyclocarya paliurus, white paeony root and chrysanthemum according to parts by weight;
(2) putting felwort, radix bupleuri, plantain, cyclocarya paliurus, radix paeoniae alba and chrysanthemum into a marmite, then adding water with the weight 4 times that of the medicines into the marmite, and decocting the mixture for 30min by using slow fire;
(3) putting the coix seeds into a frying pan, frying the coix seeds to be yellow by strong fire, taking out the coix seeds, and cooling the coix seeds for later use;
(4) putting the fried-yellow coix seeds into a marmite, and decocting for 15min by using slow fire;
(5) taking out the decocted liquid medicine and putting the liquid medicine into a medicine pot;
(6) adding water into the casserole again, decocting with strong fire until the casserole is boiled, then decocting with slow fire for 10min, taking out the liquid medicine, and putting into a medicine tank;
(7) repeating the steps twice, and mixing the three decocted medicinal soups together;
(8) and the obtained decoction is taken orally for three times.
Specifically, in the step (6), the added water is subject to the condition that the water surface is one centimeter higher than the medicine surface. .
Specifically, the three decoctions are respectively placed in different pots and finally mixed together.
In the present invention, the properties, the channels, the pharmacodynamic action and the therapeutic effects of the raw materials are as follows;
gentian: bitter taste and cold nature; entering lung and liver meridians; clearing heat and drying dampness, and purging liver and gallbladder fire; the gentian has the functions of benefiting gallbladder and protecting liver, so that the gentian has excellent curative effect on diabetes patients with damp-heat in the gallbladder;
bupleurum root: bitter, pungent and slightly cold; it enters liver and gallbladder meridians; relieving exterior syndrome, relieving fever, dispersing stagnated liver qi, and invigorating yang qi; the bupleurum contains saikoside, wherein the saikoside has anti-inflammatory effect, the anti-inflammatory effect is related to the function of promoting adrenal cortex system, and the like, and the saikoside also has the effect of reducing plasma cholesterol; therefore, the radix bupleuri has better effects of resisting fatty liver, resisting liver injury, benefiting gallbladder, reducing transaminase, exciting smooth muscles of intestines, inhibiting gastric acid secretion, resisting ulcer, inhibiting trypsin and the like, and also has the effects of resisting influenza virus, increasing protein biosynthesis, resisting tumor, resisting radiation, enhancing immune function and the like, so that the immunity of a patient can be improved and the liver and the gallbladder of the patient can be protected by adding the radix bupleuri in the formula.
Plantain herb: sweet and cold in nature; it enters liver, kidney and bladder meridians; clearing away heat, promoting urination, cooling blood, and removing toxic substances; because the damp-heat in the liver and the gallbladder can cause scanty and brownish urine of patients, the plantain herb has the curative effects of clearing heat, promoting urination and detoxifying, so the plantain herb has good urination and detoxifying effects for treating the gallbladder damp-heat type diabetes patients;
coix seed: sweet and cool in nature; spleen, stomach, lung meridian entered; promoting diuresis, eliminating dampness, invigorating spleen, relieving diarrhea, removing arthralgia, expelling pus, removing toxic substance, and resolving hard mass; the coix seed has the effects of reducing blood sugar and blood pressure, reducing blood sugar and blood pressure for patients, protecting spleen, enhancing renal function and promoting urination, and the coix seed has the effects of promoting metabolism and reducing gastrointestinal burden, can be used as tonifying food for patients in or after illness and weak body, can enhance the physique of the patients and is beneficial to rehabilitation;
cyclocarya paliurus: slightly bitter and warm in nature; unknown; clearing heat and relieving swelling; the coumarins and flavonoids in cyclocarya paliurus have effects of reducing blood sugar, resisting cancer and bacteria, improving blood circulation, and protecting permeability of blood vessel; the medicine also has the function of lowering blood pressure, the mechanism is to recover the structure and the function of pathological islet cells and increase insulin receptors of peripheral tissues, so that the medicine is greatly helpful for treating diabetes, the immunity of a patient can be increased, and the occurrence of complications of the patient can be reduced by matching with dogwood;
white peony root: bitter and sour, slightly cold in nature; entering liver and spleen meridians; nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain, and suppressing liver yang; considering that the liver-gallbladder damp-heat type thirst patients are easy to have symptoms such as liver-yin deficiency, liver-yang hyperactivity, dizziness, tinnitus, limb numbness and the like, the radix paeoniae alba can reduce the occurrence of symptoms, help the patients to recover early and achieve the treatment effect;
chrysanthemum: pungent, sweet and bitter; entering lung and liver meridians; dispelling wind and heat, suppressing liver yang, removing liver heat, improving eyesight, and clearing away heat and toxic materials; the chrysanthemum and the white peony root are decocted together for taking, the traditional Chinese medicine decoction has better curative effects on treating symptoms such as liver yin deficiency, liver yang hyperactivity, dizziness, tinnitus, limb numbness and the like, can improve the treatment effect, has the effects of expanding coronary artery, increasing coronary blood flow and improving myocardial oxygen consumption, has the effects of reducing blood pressure, shortening blood coagulation time, relieving fever, resisting inflammation and calming, and can treat conjunctival congestion and swelling pain caused by liver meridian wind heat or liver fire attack, so the curative effect of the formula disclosed by the invention is enhanced.
And (3) observation of clinical curative effect:
firstly, selecting a medical record: 100 patients with diabetes were selected for clinical observation, and patients were randomly divided into two groups, 50 treatment groups, wherein 28 men and 22 women were aged 40-75 years, the average age was 53 years, the course of disease was 1-5 years, and the average age was 3.5 years; the disease of 50 control groups, 30 men, 20 women, the age of 40-75 years, the average age of 54 years, 1-6 years of disease and the average age of 3.7 years are basically consistent and comparable, and the diet of two groups is controlled according to the requirements.
II, a test method: the patients in the treatment group take the Chinese herbal preparation (prepared according to the formula of the embodiment) for oral administration, one dose of the Chinese herbal preparation is decocted with water for one day, 3 times a day, 14 days are taken as a treatment course, 2-6 treatment courses are continuously taken, and the dosage is increased for patients with serious illness; the control group used the diabetes pill, as indicated.
Thirdly, judging the curative effect:
(1) and curing: the symptoms of polydipsia, polyphagia, polyuria and emaciation of the diabetes disappear, and the blood sugar is normal;
(2) and (3) improvement: the symptoms of polydipsia, polyphagia, polyuria and emaciation of the thirst disease disappear or are slightly accurate, and the blood sugar does not fluctuate;
(3) and (3) invalidation: no change in clinical symptoms.
Fourthly, test results:
treatment groups: 35 cases are cured, 12 cases are improved, 3 cases are invalid, the cure rate is 70%, and the total effective rate is 94%;
control group: 32 cases are cured, 10 cases are improved, 8 cases are not effective, the cure rate is 64 percent, and the total effective rate is 84 percent.
The above results show that: the cure rate and the total effective rate of the treatment group are obviously higher than those of the control group.
Typical cases are:
case one: li Yi, female, age 44, suffering from diabetes for more than 2 years, the patient suffering from diabetes is bitter in mouth, dry in mouth, full in chest and hypochondrium, poor appetite, much water intake, frequent urination, emaciation and abnormal stool in nearly 2 months, the patient is diagnosed with diabetes by checking 11.0mmol/L of blood sugar and urine sugar (++), the Chinese herbal preparation (prepared according to the formula) is taken, the symptoms disappear after 5 courses of treatment, the blood sugar is normal, the urine sugar is normal, follow-up visits are carried out later, no recurrence is caused, and the clinical recovery is achieved.
Case two: the disease is yellow and 47 years old for women, patients with diabetes are more than 1 year old without paying attention, patients with hypochondriac distending pain, dry mouth, bitter taste, thirst desire for drinking, urine output increase, and occasionally pruritus vulvae accompanied with emaciation, 9.7mmol/L of the disease is diagnosed as the diabetes through examination, after taking the Chinese herbal preparation (prepared according to the formula) for 4 courses, the symptoms disappear, the blood sugar and the urine sugar are normal, the follow-up visit is carried out, no relapse occurs, and the clinical recovery is realized.
Case three: guo of a male, 51 years old, suffering from diabetes for more than 2 years, without systemic administration, patients with dry mouth, bitter mouth, thirst desire for drinking, frequent micturition, distending pain in the two ribs, accompanied by emaciation, 8.7mmol/L after examination, the diabetes is diagnosed, after taking the Chinese herbal preparation (prepared according to the formula) of the invention for 4 courses, the symptoms disappear, the blood sugar and the urine sugar are normal, the follow-up is followed, no recurrence is caused, and the clinical recovery is realized.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (5)
1. A treatment formula for liver and gallbladder damp-heat type thirst disease is characterized in that: the composite material comprises the following raw materials in parts by weight: 20-30 g of gentian, 28-35 g of radix bupleuri, 18-22 g of plantain, 21-28 g of coix seed, 28-35 g of cyclocarya paliurus, 13-19 g of white peony root and 18-23 g of chrysanthemum.
2. The formula for treating liver and gallbladder dampness-heat type thirst disease according to claim 1, which comprises the following raw materials in parts by weight: 25 g of gentian, 30 g of radix bupleuri, 20 g of plantain, 25 g of semen coicis, 30 g of cyclocarya paliurus, 15 g of white paeony root and 20 g of chrysanthemum.
3. The method for preparing a formulation for treating thirst due to damp-heat in the liver and gallbladder according to any one of claims 1-2, comprising the steps of:
(1) taking gentian, radix bupleuri, plantain, coix seed, cyclocarya paliurus, white paeony root and chrysanthemum according to parts by weight;
(2) putting felwort, radix bupleuri, plantain, cyclocarya paliurus, radix paeoniae alba and chrysanthemum into a marmite, then adding water with the weight 4 times that of the medicines into the marmite, and decocting the mixture for 30min by using slow fire;
(3) putting the coix seeds into a frying pan, frying the coix seeds to be yellow by strong fire, taking out the coix seeds, and cooling the coix seeds for later use;
(4) putting the fried-yellow coix seeds into a marmite, and decocting for 15min by using slow fire;
(5) taking out the decocted liquid medicine and putting the liquid medicine into a medicine pot;
(6) adding water into the casserole again, decocting with strong fire until the casserole is boiled, then decocting with slow fire for 10min, taking out the liquid medicine, and putting into a medicine tank;
(7) repeating the steps twice, and mixing the three decocted medicinal soups together;
(8) and the obtained decoction is taken orally for three times.
4. The method for preparing a formula for treating thirst disease due to damp-heat in liver and gallbladder according to claim 1, wherein in the step (6), the water is added until the water level is higher than the medicine level by one centimeter.
5. The method of claim 1, wherein the three decoctions are placed in different pots and mixed.
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