CN117771330A

CN117771330A - Traditional Chinese medicine composition and traditional Chinese medicine preparation for improving gout and preparation method and application thereof

Info

Publication number: CN117771330A
Application number: CN202410045873.8A
Authority: CN
Inventors: 蔡晓卫
Original assignee: Hunan Qingchunxiang Traditional Chinese Medicine Research Institute
Current assignee: Hunan Qingchunxiang Traditional Chinese Medicine Research Institute
Priority date: 2024-01-12
Filing date: 2024-01-12
Publication date: 2024-03-29

Abstract

The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition and a traditional Chinese medicine preparation for improving gout, and a preparation method and application thereof. The traditional Chinese medicine composition for improving gout is prepared from the following medicinal materials in parts by weight: 6-13 parts of rhizoma atractylodis, 6-13 parts of amur corktree bark, 5-13 parts of medicinal cyathula root, 22-37 parts of coix seed, 13-25 parts of yam rhizome, 10-20 parts of oriental waterplantain rhizome, 10-20 parts of glabrous greenbrier rhizome, 5-12 parts of herba lycopi and 5-12 parts of sappan wood. The Chinese medicinal composition is prepared from cortex Phellodendri, rhizoma Atractylodis, coicis semen and Achyranthis radix, and has effects of clearing heat and promoting diuresis. Rhizoma Dioscoreae Septemlobae and rhizoma Smilacis Glabrae have effects of clearing away heat and dampness, dredging joint, removing arthralgia, and relieving pain, and are ministerial drugs. Sappan wood and herba lycopi have the effects of promoting blood circulation to remove blood stasis, relaxing tendons and activating collaterals, and relieving swelling and pain, and are guiding drugs. Alismatis rhizoma is good at dispelling heat, promoting urination, and promoting excretion of damp-heat, and is a guiding drug. The medicines are combined to clear damp-heat and remove swelling and pain, and have good effects on improving gout.

Description

Traditional Chinese medicine composition and traditional Chinese medicine preparation for improving gout and preparation method and application thereof

Technical Field

The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition and a traditional Chinese medicine preparation for improving gout, and a preparation method and application thereof.

Background

Gout is a recurrent inflammatory disease caused by increased purine biosynthesis and metabolism, excessive uric acid production or elevated uric acid in blood due to poor uric acid excretion, and deposition of urate crystals in joint synovium, bursa, cartilage and other tissues. It is a group of heterologous diseases caused by the precipitation of monosodium urate crystals (MSU) or uric acid in the extracellular fluid in a supersaturated state, causing the crystals to deposit in tissues. The disease is characterized in that single-water sodium urate crystals with double refraction can be found in joint fluid and tophus. The clinical characteristics are as follows: hyperuricemia, characteristic acute arthritis, tophus and interstitial nephritis caused by urate crystallization and deposition, joint deformity and dysfunction are serious, and uric acid urinary tract calculus is often accompanied.

The acute gout is usually treated by colchicine, if necessary, an analgesic agent such as indomethacin is matched, but the colchicine has severe toxicity, nausea, vomiting, diarrhea, abdominal pain and gastrointestinal reaction are precursor symptoms of severe poisoning, and kidney damage such as hematuria, oliguria, direct inhibition on bone marrow, granulocyte deficiency, aplastic anemia and the like can also occur in severe cases. Chronic gout should keep low purine diet, long-term administration of probenecid (carboxybenzene sulfonamide) can increase uric acid excretion of kidney, and probenecid has great irritation to gastrointestinal tract, can cause nausea, emesis, abdominal discomfort, anorexia, etc., and can even cause gastric ulcer.

In traditional Chinese medicine, gout belongs to the category of arthralgia syndrome, which is also called "calendar section" or "white tiger calendar section". Modern traditional Chinese medicine considers that gout is caused by joint numbness, soreness and pain of limbs and joints due to blockage of channels and collaterals, invasion of wind-cold dampness and stagnation of qi and blood, and the activities of patients are limited, and the pathological mechanism is characterized by deficiency and excessive pathogenic factors, deficiency refers to deficiency of liver and kidney, deficiency of qi and blood, accumulation of stagnant toxin and spleen deficiency and excessive dampness.

The traditional Chinese medicine for treating gout comprises two parts of uric acid reduction and gout arthritis control, and compared with western medicine treatment, the traditional Chinese medicine has smaller damage to human bodies and wider application prospect. For example, patent application CN116370585A discloses a traditional Chinese medicine composition for treating gout and a preparation method thereof, and the raw materials comprise 20-30 g of semen plantaginis, 10-20 g of medicinal cyathula root, 25-30 g of climbing fern spore, 10-15 g of Indian iphigenia bulb, 20-25 g of kudzuvine root, 25-30 g of lysimachia christinae hance, 14-18 g of poria cocos, 90-120 g of coix seed and 10-15 g of radix clematidis. Wherein semen plantaginis, herba Lysimachiae Christinae, poria, radix Clematidis and radix Puerariae all have uric acid reducing effect; the effective component of Pseudobulbus Cremastrae seu pleiones is colchicine, and has antiinflammatory and analgesic effects; both spora Lygodii and radix Clematidis have analgesic effect; radix Cyathulae has effects of strengthening tendons and bones, nourishing liver and kidney; the coix seed has the functions of strengthening spleen, promoting diuresis and dredging channels and collaterals. The composition still contains colchicine as an active ingredient, and damage to human bodies cannot be avoided.

Disclosure of Invention

Based on the technical background, the invention mainly aims to provide a traditional Chinese medicine composition and a traditional Chinese medicine preparation for improving gout, and a preparation method and application thereof, so as to overcome the defects in the prior art.

In order to achieve the purpose of the invention, the technical scheme adopted by the invention comprises the following steps:

the invention provides a traditional Chinese medicine composition for improving gout, which is prepared from the following raw materials in parts by weight:

the traditional Chinese medicine composition for improving gout is prepared from the following medicinal materials in parts by weight: 6-13 parts of rhizoma atractylodis, 6-13 parts of amur corktree bark, 5-13 parts of medicinal cyathula root, 22-37 parts of coix seed, 13-25 parts of yam rhizome, 10-20 parts of oriental waterplantain rhizome, 10-20 parts of glabrous greenbrier rhizome, 5-12 parts of herba lycopi and 5-12 parts of sappan wood.

Preferably, the traditional Chinese medicine composition for improving gout is prepared from the following medicinal materials in parts by weight: 7-11 parts of rhizoma atractylodis, 7-11 parts of phellodendron, 7-11 parts of medicinal cyathula root, 25-35 parts of coix seed, 15-22 parts of yam rhizome, 12-18 parts of rhizoma alismatis, 12-18 parts of glabrous greenbrier rhizome, 7-11 parts of herba lycopi and 7-11 parts of sappan wood.

More preferably, the traditional Chinese medicine composition for improving gout is prepared from the following medicinal materials in parts by weight: 9 parts of rhizoma atractylodis, 9 parts of phellodendron, 9 parts of medicinal cyathula root, 30 parts of coix seed, 18 parts of yam rhizome, 15 parts of rhizoma alismatis, 15 parts of rhizoma smilacis glabrae, 9 parts of herba lycopi and 9 parts of sappan wood.

Preferably, the traditional Chinese medicine composition further comprises 4-6 parts by weight of rheum officinale.

More preferably, the Chinese medicinal composition further comprises 5 parts by weight of rheum officinale. .

The second aspect of the invention provides a traditional Chinese medicine preparation for improving gout, which comprises the traditional Chinese medicine composition for improving gout according to the first aspect of the invention, and preferably, the traditional Chinese medicine preparation for improving gout is in a decoction form.

The third aspect of the invention provides a preparation method of the decoction formulation for improving gout, which comprises the following steps: decocting the materials in water.

Preferably, the mass ratio of the medicinal materials to the water is 1: (5-10).

Preferably, the weighed medicinal materials are added into water and decocted for 30-120 min at 100 ℃.

The fourth aspect of the invention is to provide an application of the traditional Chinese medicine composition for improving gout according to the first aspect of the invention in preparing medicines for treating or preventing gout or treating gout.

The invention has the beneficial effects that:

(1) The invention takes phellodendron, rhizoma atractylodis, coix seed and medicinal cyathula root as principal drugs. Dioscorea opposite in flavor can clear damp-heat, promote joint movement, remove arthralgia and relieve pain, so it is used as an ministerial drug. The long-term illness is difficult to get through due to stasis and pain, so besides the medicine for clearing damp-heat, some medicines for promoting blood circulation and removing blood stasis and clearing and activating the channels and collaterals are used, and the two medicines of sappan wood and herba lycopi can not only promote blood circulation and remove blood stasis, relax tendons and activate collaterals, but also detumescence and relieving pain, and are used for gout in a very short time, so the medicine is used as a guiding medicine. Alismatis rhizoma is good at dispelling heat, promoting urination, and facilitating excretion of damp-heat (uric acid), which can be called as bottom-of-stillage for salary, and is a guiding drug. The combination of the herbs can clear damp-heat and relieve swelling and pain, and cure the disease.

(2) The traditional Chinese medicine composition disclosed by the invention does not contain colchicine active ingredients and does not generate great toxic or side effects on human bodies.

(3) The traditional Chinese medicine composition provided by the invention is simple in application method, and can be taken after being decocted in water.

Detailed Description

The features and advantages of the present invention will become more apparent and evident from the following detailed description of the invention.

The invention provides a traditional Chinese medicine composition for improving gout, which is prepared from the following medicinal materials in parts by weight: 6-13 parts of rhizoma atractylodis, 6-13 parts of amur corktree bark, 5-13 parts of medicinal cyathula root, 22-37 parts of coix seed, 13-25 parts of yam rhizome, 10-20 parts of oriental waterplantain rhizome, 10-20 parts of glabrous greenbrier rhizome, 5-12 parts of herba lycopi and 5-12 parts of sappan wood.

According to a preferred embodiment of the present invention, the Chinese medicinal composition further comprises 4 to 6 parts by weight of rhubarb, preferably, the Chinese medicinal composition further comprises 5 parts by weight of rhubarb.

Radix et rhizoma Rhei, and Alismatis rhizoma can be added to relieve constipation to be used together as a guiding drug. However, it is not suitable for long-term administration because it is cold in nature and purging heat to relieve constipation, and young people can take it seven days before, and after seven days, the rhubarb is removed, and other medicines can be used continuously, so that the old and weak people can be free from rhubarb.

Rhizoma atractylodis: pungent and bitter in flavor and warm in nature. It enters spleen, stomach and liver meridians. Dry dampness, invigorate spleen, expel wind, dispel cold, improve eyesight. Can be used for treating damp obstruction of middle energizer, abdominal distention, diarrhea, edema, tinea pedis, rheumatalgia, common cold due to wind-cold, night blindness, and dim eyesight.

Cortex Phellodendri: bitter in flavor and cold in nature. Kidney and bladder meridians. Has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic substances, and treating sore. Can be used for treating damp-heat diarrhea, jaundice, dark urine, itching and leukorrhagia, heat stranguria, tinea pedis, night sweat, spermatorrhea, pyocutaneous disease, swelling and toxin, and eczema. Salted phellodendron bark, cortex Phellodendri, radix Phellodendri, has the effect of nourishing yin to reduce pathogenic fire. Is used for treating night sweat and bone steaming due to yin deficiency and fire excess.

Radix Cyathulae: sweet and slightly bitter in flavor, neutral in nature. It enters liver and kidney meridians. Removing blood stasis, dredging channels, promoting diuresis and treating stranguria. Can be used for treating amenorrhea, abdominal mass, traumatic injury, rheumatalgia, foot flaccidity, tendons contracture, hematuria, and blood stranguria.

Coix seed: sweet; light; slightly cold. Spleen; a lung; kidney meridian. Promoting diuresis and invigorating spleen; relaxing tendons and removing arthralgia; clear heat and expel pus. Major oedema; beriberi; dribbling urine; wet and warm diseases; diarrhea under the belt; rheumatalgia; the spasm of tendons and vessels; pulmonary abscess; acute appendicitis; flat wart

Rhizoma Dioscoreae Septemlobae: bitter and flat. Enter kidney and stomach meridians. Remove dampness and turbid pathogen, dispel wind and remove arthralgia. Can be used for treating stranguria due to plaster, turbid urine, leukorrhagia, rheumatalgia, joint disorder, and lumbago and gonalgia.

Oriental Waterplantain rhizome: sweet and light in taste and cold in nature. Enter kidney and bladder meridians. Induce diuresis and excrete dampness, drain heat, resolve turbidity and reduce lipid. Can be used for treating dysuria, edema, distention, diarrhea, oliguria, dizziness due to phlegm and fluid, stranguria due to heat, and hyperlipidemia.

Rhizoma smilacis glabrae: sweet, light and flat. Enter liver and stomach meridians. Detoxify, remove dampness, promote the circulation of the joints. Limb contracture, bone and muscle pain caused by syphilis and mercury poisoning; damp-heat stranguria with turbid urine, leukorrhagia, carbuncle, scrofula and scabies.

Herba Lycopi: bitter and pungent, and slightly warm. Enter liver and spleen meridians. Promoting blood circulation, regulating menstruation, removing blood stasis, resolving carbuncle, inducing diuresis and relieving edema. It can be used for treating menoxenia, amenorrhea, dysmenorrhea, puerperal abdominal pain due to blood stasis, sore, carbuncle, toxic swelling, edema, and ascites.

Sappan wood: sweet, salty, flat. It enters heart, liver and spleen meridians. Promoting blood circulation, removing blood stasis, and relieving swelling and pain. Can be used for treating traumatic injury, fracture, injury of tendons, stasis, swelling and pain, amenorrhea, dysmenorrhea, puerperal stasis, thoracoabdominal pain, carbuncle, and swelling and pain.

Rhubarb: it enters spleen, stomach, large intestine, liver and pericardium meridians. Bitter and cold. Purging heat, removing heat from the intestines, cooling blood, removing toxin, removing blood stasis and dredging channels. Can be used for treating constipation due to excessive heat, abdominal pain due to stagnation, diarrhea, jaundice due to damp-heat, hematemesis, conjunctival congestion, pharyngeal swelling, intestinal abscess, abdominal pain, carbuncle, furuncle, blood stasis, amenorrhea, traumatic injury, and external scald due to pathogenic fire and water; upper gastrointestinal hemorrhage. The excessive heat and toxicity of the upper energizer and blood system of the wine is Huang Shanqing. Can be used for treating conjunctival congestion, pharyngeal swelling, and gingival swelling and pain. The cooked rhubarb has the effects of purging the lower power, purging the pathogenic fire and removing toxin, and is used for treating sores and ulcers caused by fire toxin. The rhubarb charcoal is used for cooling blood, removing blood stasis and stopping bleeding and is used for treating bleeding caused by blood heat and blood stasis.

According to a fourth aspect of the invention, there is provided the use of the traditional Chinese medicine composition for improving gout according to the first aspect of the invention, wherein the traditional Chinese medicine composition for improving gout can be used for preparing medicines for treating or preventing gout or treating gout.

Examples

The invention is further illustrated by the following specific examples, which are intended to be illustrative of the invention and are not intended to limit the scope of the invention.

Example 1

9g of rhizoma atractylodis, 9g of cortex phellodendri, 9g of radix cyathulae, 30g of pearl barley, 18g of yam rhizome, 15g of rhizoma alismatis, 15g of rhizoma smilacis glabrae, 9g of herba lycopi, 9g of sappan wood and 5g of rheum officinale are weighed.

The weighed medicinal materials are added into 1000mL of water and decocted for 60min at 100 ℃ to obtain the decoction for improving gout.

Example 2

7g of rhizoma atractylodis, 11g of cortex phellodendri, 11g of radix cyathulae, 25g of pearl barley, 15g of yam rhizome, 12g of rhizoma alismatis, 18g of rhizoma smilacis glabrae, 7g of herba lycopi, 11g of sappan wood and 4g of rheum officinale are weighed.

The weighed medicinal materials are added into 1200mL of water and decocted for 120min at 100 ℃ to obtain the decoction for improving gout.

Example 3

Weighing rhizoma Atractylodis 11g, cortex Phellodendri 7g, radix Cyathulae 7g, coicis semen 35g, rhizoma Dioscoreae Septemlobae 22g, alismatis rhizoma 18g, rhizoma Smilacis Glabrae 12g, herba Lycopi 11g, lignum sappan 7g, and radix et rhizoma Rhei 6g.

The weighed medicinal materials are added into 700mL of water and decocted for 30min at 100 ℃ to obtain the decoction for improving gout.

Example 4

9g of rhizoma atractylodis, 9g of cortex phellodendri, 9g of radix cyathulae, 30g of pearl barley, 18g of yam rhizome, 15g of rhizoma alismatis, 15g of rhizoma smilacis glabrae, 9g of herba lycopi and 9g of sappan wood are weighed.

Comparative example

Comparative example 1

The preparation of a decoction for improving gout was carried out in a similar manner to example 1, except that: herba Lycopi is replaced by herba Lysimachiae Christinae with effects of dispelling blood stasis and relieving swelling.

Comparative example 2

The preparation of a decoction for improving gout was carried out in a similar manner to example 1, except that: the sappan wood is replaced by the desmodium which has the functions of dispersing blood stasis and detumescence.

Comparative example 3

The preparation of a decoction for improving gout was carried out in a similar manner to example 1, except that: the rheum officinale is replaced by peach seed with the effect of relaxing bowel.

Experimental example

Experimental example 1 clinical application study

The gout-improving decoction prepared in examples 1-4 and comparative examples 1-3 was used for clinical application research. 140 gout patients are selected, and the case selection is judged by referring to the diagnosis standard of gouty arthritis in gout: (1) the joint fluid has specific urate crystals; (2) a tophus with urate crystals is confirmed by a chemical method or a polarizing microscope; (3) with 6 of the following 12 clinical, laboratory and radiographic signs: more than one acute arthritis episode; inflammation is manifested by a peak within 1 day; monoarthritis; reddening of joints; swelling or pain of the 1 st metatarsophalangeal joint; unilateral attacks involving the 1 st metatarsophalangeal joint; unilateral tarsal joint involvement; suspicious tophus; hyperuricemia; asymmetric swelling in the X-ray radiograph joint; x-ray film shows that subcortical capsule changes without bone erosion; the arthritis onset period joint fluid microorganisms were negative in culture.

Exclusion criteria: allergic to the drug by an age below 18 years old or above 65 years old; combining gouty nephropathy and renal insufficiency; patients with serious primary diseases and psychosis such as heart, liver, kidney, brain and hematopoietic system; severe deformity and disability of advanced arthritis; the efficacy evaluation or safety judgment cannot be judged if the drug is not administered according to the regulations, such as efficacy or incomplete data.

The patients were randomly divided into 7 groups, and the patients were administered with no significant difference in age and sex, respectively, with the decoction for improving gout obtained by decocting according to the preparation methods of examples 1-4 and comparative examples 1-3, once daily, for 2 weeks continuously, with no beer, seafood or spicy taste.

The curative effect standard refers to the relevant curative effect standard in the traditional Chinese medicine disease judgment curative effect standard:

and (3) healing: all clinical symptoms disappeared and the laboratory examined as normal.

Improvement: clinical symptoms are reduced, laboratory tests are improved or normal.

Invalidation: the clinical symptoms are not obviously improved or aggravated.

The symptoms of the patients were counted after 2 weeks and the results are shown in table 1.

TABLE 1

Group of	The number of people	Healing of the wound	Improvement of	Invalidation of	Total effective rate (%)
						Example 1	20	15	5	0	100
Example 2	20	13	6	1	95
						Example 3	20	14	5	1	95
Example 4	20	12	6	2	90
						Comparative example 1	20	10	5	5	75
Comparative example 2	20	9	5	6	70
						Comparative example 3	20	10	4	6	70

The uric acid and blood sedimentation values before and after treatment were measured for each group of patients, and the test results are shown in table 2.

TABLE 2

Note that: * P <0.05 represents a significant difference between the columns of data.

From table 1, it can be seen that the decoction for improving gout according to embodiments 1-4 of the present invention has good therapeutic effects on gout. The treatment effect is reduced after herba Lycopi or lignum sappan is substituted for herba Lysimachiae Christinae, and the treatment effect is also reduced after radix et rhizoma Rhei is substituted for semen Persicae. The traditional Chinese medicine composition disclosed by the invention is inexhaustible in medicinal materials, and a good treatment effect can be achieved only through combined action. Meanwhile, the treatment effect of the embodiment 1 is better than that of the embodiments 2-4, which shows that the traditional Chinese medicine composition has better treatment effect when the medicinal materials are decocted according to the addition amount of the embodiment 1.

As can be seen from Table 2, the gout-improving decoction prepared in examples 1-4 can greatly reduce the blood uric acid and blood sedimentation value of patients.

The invention has been described in detail in connection with the specific embodiments and exemplary examples thereof, but such description is not to be construed as limiting the invention. It will be understood by those skilled in the art that various equivalent substitutions, modifications or improvements may be made to the technical solution of the present invention and its embodiments without departing from the spirit and scope of the present invention, and these fall within the scope of the present invention. The scope of the invention is defined by the appended claims.

Claims

1. The traditional Chinese medicine composition for improving gout is characterized by being prepared from the following medicinal materials in parts by weight: 6-13 parts of rhizoma atractylodis, 6-13 parts of amur corktree bark, 5-13 parts of medicinal cyathula root, 22-37 parts of coix seed, 13-25 parts of yam rhizome, 10-20 parts of oriental waterplantain rhizome, 10-20 parts of glabrous greenbrier rhizome, 5-12 parts of herba lycopi and 5-12 parts of sappan wood.

2. The traditional Chinese medicine composition for improving gout according to claim 1, wherein,

the traditional Chinese medicine composition for improving gout is prepared from the following medicinal materials in parts by weight: 7-11 parts of rhizoma atractylodis, 7-11 parts of phellodendron, 7-11 parts of medicinal cyathula root, 25-35 parts of coix seed, 15-22 parts of yam rhizome, 12-18 parts of rhizoma alismatis, 12-18 parts of glabrous greenbrier rhizome, 7-11 parts of herba lycopi and 7-11 parts of sappan wood.

3. The traditional Chinese medicine composition for improving gout according to claim 2, wherein,

the traditional Chinese medicine composition for improving gout is prepared from the following medicinal materials in parts by weight: 9 parts of rhizoma atractylodis, 9 parts of phellodendron, 9 parts of medicinal cyathula root, 30 parts of coix seed, 18 parts of yam rhizome, 15 parts of rhizoma alismatis, 15 parts of rhizoma smilacis glabrae, 9 parts of herba lycopi and 9 parts of sappan wood.

4. The traditional Chinese medicine composition for improving gout according to claim 1, wherein,

the traditional Chinese medicine composition also comprises 4-6 parts by weight of rheum officinale.

5. The Chinese medicinal composition for improving gout according to claim 4, wherein,

the traditional Chinese medicine composition also comprises 5 parts by weight of rheum officinale.

6. A traditional Chinese medicine preparation for improving gout, which is characterized by comprising the traditional Chinese medicine composition for improving gout according to one of claims 1 to 5;

the traditional Chinese medicine preparation for improving gout is in a decoction form.

7. A method for preparing the traditional Chinese medicine preparation for improving gout according to claim 6, which comprises the following steps:

decocting the materials in water.

8. The method of claim 7, wherein the step of determining the position of the probe is performed,

the mass ratio of the medicinal materials to the water is 1: (5-10).

9. The method of claim 7, wherein the step of determining the position of the probe is performed,

the weighed medicinal materials are added into water and decocted for 30 to 120 minutes at the temperature of 100 ℃.

10. Use of a Chinese medicinal composition for improving gout according to any of claims 1 to 5 for preparing a medicament for treating or preventing gout or for treating gout.