CN110772568A - Traditional Chinese medicine composition for treating radiation enteritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating radiation enteritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating radiation enteritis, which comprises the following components: the invention also discloses a preparation method of the traditional Chinese medicine composition. The formula of the invention has reasonable compatibility, can clear heat and promote diuresis, promote qi circulation and relieve pain, calm liver and regulate qi, has no obvious liver and kidney toxicity, and is suitable for being applied to the treatment of radiation enteritis.
Description
Technical Field
The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition for treating radiation enteritis and a preparation method thereof.
Background
The radiation enteritis is a common complication after the radiation therapy of the abdominal and pelvic tumors, is clinically manifested by abdominal pain, diarrhea, discharging mucus and bloody stool, severe symptoms of the severe patients are severe and last for a long time, even serious diseases such as intestinal necrosis, vaginal and rectal fistula and the like occur, and adverse effects are brought to normal life and subsequent treatment. Modern medicine considers that congestion, edema, ulcer and erosion of intestinal mucosa with secretion or bleeding are the main pathological changes, and radioactive substances damaging the intestinal mucosa, blood vessels and connective tissues are the main reasons for the disease. There is no specific means for treating radiation enteritis after abdominopelvic tumor radiotherapy in western medicine, and the method mainly aims at symptomatic intervention, and mainly aims at surgical treatment for chronic radiation enteritis, and the method mainly aims at relieving local symptoms and protecting gastrointestinal mucosa for acute radiation enteritis patients by adopting antibiotic, hemostasis, hormone, antidiarrheal, enema and other symptomatic support treatments, but has a not ideal effect on improving the overall life quality of patients. In recent years, the traditional Chinese medicine is gradually applied to the auxiliary treatment of complications after the radiation therapy of the pelvic tumor and achieves certain effects by virtue of the multi-target and multi-relief treatment advantages of the traditional Chinese medicine. The traditional Chinese medicine holds that a tumor patient is originally weak in vital qi, and radiation therapy is added to the deficiency of vital qi, so that heat and toxin are accumulated in intestines due to toxic injury of 'fire and heat' and the intestinal tract is injured, and the intestinal tract is disordered and causes diseases. Therefore, heat-clearing and blood-cooling prescriptions are mostly adopted for treatment, but most of the medicines ignore liver calming and qi regulating, but only detoxify and remove dampness with one taste, and do not take overall regulation from liver and kidney.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition which can clear heat and promote diuresis, promote qi circulation and relieve pain, calm liver and regulate qi and has no obvious liver and kidney toxicity and a preparation method thereof, and the traditional Chinese medicine composition is suitable for being applied to the treatment of radiation enteritis.
The technical scheme adopted by the invention is as follows: a Chinese medicinal composition for treating radiation enteritis comprises rhizoma Eucommiae, Scutellariae radix, fructus Solani Melongenae, fructus forsythiae, fructus Aurantii, radix aucklandiae, herba Alii Fistulosi, and Glycyrrhrizae radix;
furthermore, the weight parts of the components are 25-30 parts of eucommia ulmoides, 25-30 parts of radix scutellariae, 15-20 parts of solanum melongena, 15-20 parts of fructus forsythiae, 5-10 parts of fructus aurantii, 5-10 parts of radix aucklandiae, 1-5 parts of chive and 1-5 parts of liquorice;
further, the weight parts of the components are 27-30 parts of eucommia ulmoides, 27-30 parts of radix scutellariae, 16-18 parts of solanum melongena, 16-18 parts of fructus forsythiae, 8-10 parts of fructus aurantii, 5-7 parts of radix aucklandiae, 2-4 parts of chive and 2-4 parts of liquorice;
further, the dosage form of the traditional Chinese medicine composition is selected from: decoction, capsule, tablet or powder;
furthermore, the dosage form of the traditional Chinese medicine composition is preferably tablets or decoction.
The invention also discloses a preparation method of the traditional Chinese medicine composition for treating radiation enteritis, and when the dosage form of the traditional Chinese medicine composition is a tablet, the preparation method comprises the following steps:
crushing the raw materials into granules, sieving, mixing, adding water with the mass 20-40 times of that of the raw material mixture, soaking for 1-3 hours, decocting for 1-3 hours with small fire, filtering the obtained decoction, decocting with big fire until the decoction is nearly dry, adding excipient into the obtained sticky matter, and tabletting to obtain the product;
when the dosage form of the traditional Chinese medicine composition is decoction, the preparation method comprises the following steps:
crushing the raw materials into granules, sieving, mixing uniformly, adding water with the mass 20-40 times of that of the raw material mixture, soaking for 1-3 hours, decocting for 1-3 hours with small fire, filtering the obtained decoction, and decocting with big fire until the color of the decoction is thick to obtain the product.
The traditional Chinese medicine composition provided by the invention has the following analysis of the medicines:
middle-energizer, bitter taste, mild nature, clearing heat, diminishing inflammation, cooling blood and stopping bleeding. It can be used for treating dysentery with reddish discharge, enteritis, gastralgia, pulmonary tuberculosis hemoptysis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, and furuncle.
Bai skullcap root, bitter in taste and neutral in nature, is mainly indicated for heat-heat in gallbladder, diarrhea, watery stool, bleeding obstruction, malignant ulcer, deep-rooted carbuncle and fire ulcer.
The small eggplant is slightly sweet in taste and neutral in nature, and has the effects of clearing heat and removing toxicity, and eliminating dampness and relieving pain.
Fructus forsythiae is bitter in taste and cool in nature, and has the effects of clearing heat, detoxifying, dissipating stagnation and reducing swelling. It is indicated for warm heat, erysipelas, macula, superficial infection, abscess, swelling, scrofula and stranguria.
Fructus Aurantii, bitter, pungent and sour in flavor, slightly cold in nature, enters spleen and stomach meridians, regulates qi, relieves epigastric distention, and moves stagnation to relieve distension.
Mu Xiang is pungent and bitter in flavor, warm in nature, moving qi and alleviating pain.
Shallot, sweet in taste, slightly bitter in flavor, cold in nature, clears heat and promotes diuresis.
The liquorice has sweet taste and mild nature, and has the effects of invigorating the spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the drugs, and the liquorice has the functions of tonifying heart, lung, spleen and stomach channels.
The invention has the beneficial effects that:
1) the radiation enteritis is classified into the categories of diarrhea and intestinal nodules in the traditional Chinese medicine, the radiation enteritis is considered as the disease of deficiency of origin and marked excess, wherein the deficiency of vital qi is the origin, the pathogenic factors invade the interior, the pathogenic toxin blocks collaterals, the qi movement is stagnant, the long-term stagnation transforms into fire, the damp-heat is difficult to remove, and the restriction of conduction is finally caused to the obstruction of the fu-organ qi; radiation belongs to fire-heat toxin, and heat-damp toxin is accumulated in the intestines to aggravate the disorder of intestinal qi and cause symptoms of abdominal pain and diarrhea; when heat-toxicity scorches the intestine, damp-heat may cause blood clots and blood vessels may be damaged, pus and bloody stool may be seen. Therefore, the traditional Chinese medicine treatment of radiation enteritis mainly aims at clearing heat and promoting diuresis, and promoting qi circulation and removing toxicity. The Zhongzhongzhong in the formula can generally be considered to be capable of clearing heat, diminishing inflammation, cooling blood and stopping bleeding, the radix scutellariae which has the same effects of clearing heat and removing dryness is matched to be used as a monarch drug to strengthen the effect of treating diarrhea of thick intestines, and the solanum melongena which has the effects of removing dampness and relieving pain and the forsythia which has the effects of removing toxicity and eliminating stagnation are used as ministerial drugs to achieve the effects of removing toxicity, stopping diarrhea; the bitter orange, the elecampane and the shallot which are capable of regulating qi and relieving epigastric distention are used as adjuvant drugs, the effects of strengthening body resistance and calming the liver and protecting the spleen and stomach are achieved, the liquorice is capable of strengthening and harmonizing the drugs and playing the synergistic effects of strengthening the intestine and relieving diarrhea, calming the liver and dispelling qi, the bitter orange and the elecampane can play the effects of strengthening the spleen and protecting the liver, and promoting qi circulation and relieving distension, the liver and kidney functions can be fundamentally improved, the five internal organs are regulated, the effect of strengthening the liver to expel toxin is achieved, the heat toxin is favorably discharged, the liquorice also contains substances capable of blocking carcinogens to induce tumor growth, and the liquorice is very effective in improving the radiation enteritis.
2) The formula of the invention is characterized by the mutual compatibility of monarch, minister, assistant and guide, reasonable formula, effective improvement of synergistic effect between medicines, liver calming, qi dredging, body resistance strengthening, and body resistance strengthening, has no obvious toxic or side effect, and is suitable for being widely applied to the combination of traditional Chinese medicine and western medicine or non-western medicine treatment of radiation enteritis.
Detailed Description
Example 1:
the traditional Chinese medicine for treating radiation enteritis is prepared from the following raw material medicines in parts by weight: 28 parts of eucommia bark, 28 parts of radix scutellariae, 16 parts of solanum melongena, 16 parts of fructus forsythiae, 8 parts of fructus aurantii, 5 parts of elecampane, 2 parts of chive and 2 parts of liquorice.
The preparation method comprises the following specific steps:
crushing the raw materials into granules, sieving, mixing uniformly, adding water with the mass 40 times of that of the raw material mixture, soaking for 1 hour, decocting for 3 hours with soft fire, filtering the obtained decoction, decocting with soft fire until the decoction is nearly dry, adding sufficient starch into the obtained sticky matter, tabletting, and air drying to obtain the product.
Example 2:
the traditional Chinese medicine for treating radiation enteritis is prepared from the following raw material medicines in parts by weight: 28 parts of eucommia bark, 28 parts of radix scutellariae, 16 parts of solanum melongena, 16 parts of fructus forsythiae, 8 parts of fructus aurantii, 7 parts of elecampane, 4 parts of chive and 2 parts of liquorice.
The preparation method comprises the following specific steps:
crushing the raw materials into granules, sieving, mixing uniformly, adding water with the mass 40 times of that of the raw material mixture, soaking for 1 hour, decocting for 3 hours with soft fire, filtering the obtained decoction, and decocting with big fire until the color of the decoction is thick, thus obtaining the product.
Example 3:
120 cases of patients suffering from radiation enteritis after radiation treatment of abdominopelvic tumor treated by the hospital are selected, the patients meet the diagnosis standard in Western medicine modern oncology and traditional Chinese medicine internal science, the age is 20-70 years old, the accumulated absorbed dose of the intestinal tract exceeds 46Gy, and the KPS score is not less than 60 points. The study protocol was approved by the hospital ethics committee and informed consent was given to the patient and the family members. The above cases were randomly divided into three groups, i.e., tablet group, decoction group and control group. Three groups of patients have no significant difference in age, sex and disease course (P >0.05), and are comparable.
(II) the curative effect standard:
the treatment effect is evaluated according to the 'standard of treatment effect for diagnosis of traditional Chinese medicine diseases'.
And (3) curing: the stool frequency, the shape and the color are normal, other symptoms disappear, the clinical examination is normal, and the color of rectal mucosa is normal as seen in colonoscopy or proctoscopy;
the effect is shown: the stool frequency is reduced 2/3, the stool quality is formed, the mucous bloody stool is not generated, other symptoms are obviously reduced, the clinical examination is basically normal, and the color of the rectal mucosa is approximately normal when the rectal mucosa is detected by colonoscopy or proctoscopy;
the method has the following advantages: the stool frequency is obviously reduced, other symptoms are improved, the clinical examination is improved, and the color of the rectal mucosa seen in colonoscopy or proctoscopy is improved to some extent compared with the former color;
and (4) invalidation: the symptoms are not improved, or the symptoms are not improved in colonoscopy and proctoscopy.
And (III) 120 patients 20-70 years old who participate in statistics are divided into a tablet treatment group, a decoction treatment group and a control group, wherein each group comprises 40 persons:
tablet treatment group: three meals later, 2 tablets (about 0.2 g/tablet) at a time, three times a day, and one month continuously;
the decoction treatment group comprises: the oral liquid is taken after three meals, 150ml is taken once, three times a day, and one month is taken continuously;
control group: mesalazine tablets are taken orally 2 tablets (0.5 g/tablet) at a time, four times a day, and one month is taken continuously.
Therefore, the total effective rate of the groups treated by using the traditional Chinese medicine composition is slightly different, which shows that the adjustment of the components of the costustoot and the chive has influence on the drug effect, and no obvious hepatorenal toxicity or other toxic and side effects are found during the treatment period.
Claims (7)
1. A traditional Chinese medicine composition for treating radiation enteritis is characterized by comprising eucommia ulmoides, radix scutellariae, solanum melongena, fructus forsythiae, fructus aurantii, radix aucklandiae, shallot and liquorice.
2. The traditional Chinese medicine composition as claimed in claim 1, wherein the weight parts of the components are 25-30 parts of eucommia ulmoides, 25-30 parts of radix scutellariae, 15-20 parts of solanum melongena, 15-20 parts of fructus forsythiae, 5-10 parts of fructus aurantii, 5-10 parts of radix aucklandiae, 1-5 parts of chive and 1-5 parts of liquorice.
3. The traditional Chinese medicine composition as claimed in claim 2, wherein the weight parts of the components are 27-30 parts of rhizoma coptidis, 27-30 parts of radix scutellariae, 16-18 parts of solanum melongena, 16-18 parts of fructus forsythiae, 8-10 parts of fructus aurantii, 5-7 parts of radix aucklandiae, 2-4 parts of chive and 2-4 parts of liquorice.
4. The Chinese medicinal composition for treating radiation enteritis according to any one of claims 1 to 3, wherein the dosage form of the Chinese medicinal composition is selected from: decoction, tablet or powder.
5. The traditional Chinese medicine composition for treating radiation enteritis according to claim 4, wherein the dosage form of the traditional Chinese medicine composition is selected from tablets or decoction.
6. A method of preparing a Chinese medicinal composition for the treatment of radiation enteritis as claimed in any one of claims 1 to 5, wherein: when the dosage form of the traditional Chinese medicine composition is a tablet, the traditional Chinese medicine composition comprises the following components:
crushing the raw materials into granules, sieving, mixing, adding water with the mass 20-40 times of that of the raw material mixture, soaking for 1-3 hours, decocting for 1-3 hours with small fire, filtering the obtained decoction, decocting with big fire until the decoction is nearly dry, adding excipient into the obtained sticky matter, and tabletting to obtain the product.
7. A method of preparing a Chinese medicinal composition for the treatment of radiation enteritis as claimed in any one of claims 1 to 5, wherein: when the dosage form of the traditional Chinese medicine composition is decoction, the traditional Chinese medicine composition comprises the following components:
crushing the raw materials into granules, sieving, mixing uniformly, adding water with the mass 20-40 times of that of the raw material mixture, soaking for 1-3 hours, decocting for 1-3 hours with small fire, filtering the obtained decoction, and decocting with big fire until the color of the decoction is thick to obtain the product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111346143A (en) * | 2020-03-27 | 2020-06-30 | 王菲菲 | Traditional Chinese medicine composition for regulating liver depression and qi stagnation type obesity and preparation method thereof |
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| CN105796938A (en) * | 2014-12-29 | 2016-07-27 | 青岛百草汇中草药研究所 | Novel traditional Chinese medicine treatment method of radiation enteritis |
| CN106902266A (en) * | 2015-12-22 | 2017-06-30 | 贺国庆 | A kind of Chinese traditional treatment new method of radiation enteritis |
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| CN105796938A (en) * | 2014-12-29 | 2016-07-27 | 青岛百草汇中草药研究所 | Novel traditional Chinese medicine treatment method of radiation enteritis |
| CN106902266A (en) * | 2015-12-22 | 2017-06-30 | 贺国庆 | A kind of Chinese traditional treatment new method of radiation enteritis |
Non-Patent Citations (2)
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| 李会文等: "肠炎宁方治疗放射性肠炎32例", 《辽宁中医杂志》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111346143A (en) * | 2020-03-27 | 2020-06-30 | 王菲菲 | Traditional Chinese medicine composition for regulating liver depression and qi stagnation type obesity and preparation method thereof |
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