CN114569694B

CN114569694B - Traditional Chinese medicine composition for treating reflux esophagitis and preparation method and application thereof

Info

Publication number: CN114569694B
Application number: CN202210260461.7A
Authority: CN
Inventors: 翟少华; 李廷荃; 任顺平
Original assignee: Affiliated Hospital Of Shanxi University Of Traditional Chinese Medicine
Current assignee: Affiliated Hospital Of Shanxi University Of Traditional Chinese Medicine
Priority date: 2022-03-10
Filing date: 2022-03-10
Publication date: 2023-03-14
Anticipated expiration: 2042-03-10
Also published as: CN114569694A

Abstract

The invention relates to a traditional Chinese medicine composition for treating reflux esophagitis and a preparation method and application thereof, belonging to the technical field of traditional Chinese medicines. The invention provides a traditional Chinese medicine composition for treating reflux esophagitis, which has reasonable compatibility and has the functions of clearing heat, lowering adverse qi, promoting blood circulation, removing blood stasis and tonifying yin and relieving epigastric distention, and experiments prove that the composition can be used for fundamentally treating reflux esophagitis, and the effective rate reaches 100%.

Description

Traditional Chinese medicine composition for treating reflux esophagitis and preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating reflux esophagitis and a preparation method and application thereof.

Background

Reflux Esophagitis (RE) refers to inflammatory lesions of the esophageal mucosa caused by Reflux of gastric and duodenal contents into the esophagus, and complications such as esophageal stenosis, bleeding, perforation and Barrett's esophagus are clinically common and frequently encountered diseases. The incidence of RE is high all over the world, about 7-15% of people have gastroesophageal reflux symptoms, and the incidence of RE in western countries even exceeds 20%. The incidence rate increases with age, with an increasing prevalence above 40 years of age, more men than women with reflux esophagitis (2: 1 to 3: 1). The incidence of RE in China is about 6% on average, and the prevalence of the RE in large cities such as Beijing, shanghai, xian and the like can be as high as 17%.

The western medicine treatment methods for RE are various, but still have a plurality of defects: the conventional drug therapy adopts oral Proton Pump Inhibitor (PPI) or combined gastric motility promoting drug, can quickly improve the symptoms of patients, but has long treatment maintaining time and easy relapse after drug withdrawal; in the aspect of surgical RE treatment, dysphagia is a postoperative complication which is difficult to avoid in laparoscopic fundoplication. Dialectical treatment is the basis and core of the diagnosis and treatment system of traditional Chinese medicine and is the essence of the theory of traditional Chinese medicine. More and more clinical reports show that the traditional Chinese medicine has obvious curative effect on treating RE, so that the traditional Chinese medicine preparation for treating RE, which has good curative effect and no side effect, is necessary.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating reflux esophagitis, which has synergistic compatibility of medicines, exerts the effects of clearing heat, lowering adverse qi, promoting blood circulation, removing blood stasis and tonifying yin and relieving epigastric distention together, can effectively improve the symptoms of reflux esophagitis, and improves the curative effect on reflux esophagitis.

In order to solve the technical problems, the invention provides the following technical scheme:

the invention provides a traditional Chinese medicine composition for treating reflux esophagitis, which comprises the following raw materials in parts by weight:

15-35 parts of scutellaria baicalensis, 15-25 parts of fructus forsythiae, 12-25 parts of honeysuckle, 12-25 parts of corydalis tuber, 10-26 parts of earthworm, 10-23 parts of radix ophiopogonis, 9-21 parts of fructus aurantii, 8-20 parts of dried orange peel, 8-20 parts of radix bupleuri, 7-16 parts of rhizoma pinelliae praeparata, 5-18 parts of mangnolia officinalis, 5-18 parts of bighead atractylodes rhizome, 3-10 parts of dried ginger, 4-8 parts of platycodon grandiflorum, 3-8 parts of liquorice and 2-8 parts of sweet osmanthus flower.

Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:

18-32 parts of scutellaria baicalensis, 18-23 parts of fructus forsythiae, 16-22 parts of honeysuckle, 14-21 parts of corydalis tuber, 13-22 parts of earthworm, 12-19 parts of radix ophiopogonis, 11-18 parts of fructus aurantii, 11-18 parts of pericarpium citri reticulatae, 12-18 parts of radix bupleuri, 9-14 parts of rhizoma pinelliae preparata, 8-14 parts of mangnolia officinalis, 10-14 parts of bighead atractylodes rhizome, 5-8 parts of dried ginger, 5-7 parts of platycodon grandiflorum, 4-6 parts of liquorice and 3-7 parts of sweet osmanthus flower.

22-28 parts of scutellaria baicalensis, 20-21 parts of fructus forsythiae, 18-20 parts of honeysuckle, 16-19 parts of corydalis tuber, 16-18 parts of earthworm, 15-17 parts of radix ophiopogonis, 15-16 parts of fructus aurantii, 15-16 parts of dried orange peel, 15-17 parts of radix bupleuri, 12-13 parts of rhizoma pinelliae preparata, 10-12 parts of mangnolia officinalis, 12-13 parts of bighead atractylodes rhizome, 6-7 parts of dried ginger, 6 parts of platycodon grandiflorum, 5 parts of liquorice and 5-6 parts of sweet osmanthus.

The invention provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:

the traditional Chinese medicine composition is obtained by mixing the traditional Chinese medicine raw materials according to the weight part ratio, drying and crushing.

Preferably, the particle size of the crushed particles is less than or equal to 180 mu m.

Preferably, the water content of the dried traditional Chinese medicine raw materials is lower than 9%.

The invention also provides an oral preparation for treating reflux esophagitis, which comprises the traditional Chinese medicine composition.

Preferably, the oral preparation is powder, syrup, tincture, solution, granule, tablet, capsule, pill or extract.

The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating reflux esophagitis.

The invention provides a traditional Chinese medicine composition for treating reflux esophagitis, which is reasonable in compatibility of medicines and synergistic effect, wherein scutellaria baicalensis is used for clearing heat and drying dampness, ophiopogon root is used for nourishing yin and moistening lung, and fructus aurantii is used for regulating qi and relieving epigastric distention, and the three medicines are used as monarch medicines together, so that the effects of clearing heat and lowering adverse qi and tonifying yin and relieving epigastric distention are achieved; fructus forsythiae is used for clearing away heat and toxic materials, honeysuckle is used for cooling and dispelling wind heat, rhizoma corydalis is used for promoting blood circulation and removing blood stasis, earthworm is used for clearing away heat and dredging collaterals, pericarpium citri reticulatae is used for regulating qi and stimulating appetite, radix bupleuri is used for soothing liver and invigorating yang, and the fructus forsythiae and the radix bupleuri are used as ministerial drugs and are used for synergistically playing the effects of promoting blood circulation and removing blood stasis, clearing heat and reducing phlegm; rhizoma pinelliae preparata has the effects of relieving cough and reducing sputum, magnolia officinalis eliminates dampness and eliminates sputum, bighead atractylodes rhizome invigorates the spleen and tonifies qi, platycodon grandiflorum disperses the lung and relieves sore throat, and the rhizoma pinelliae preparata and rhizoma pinelliae preparata are used as adjuvant drugs together and have the effects of eliminating sputum and reducing sputum; the dried ginger warms the middle-jiao to dispel cold and balances the cold property of the medicine, the liquorice tonifies the spleen and qi, relieves cough and eliminates phlegm, the medicine property is harmonized, and the sweet osmanthus warms and disperses cold-phlegm to serve as a guiding medicine. The whole formula has reasonable compatibility, has the functions of clearing heat and lowering adverse qi, promoting blood circulation and removing blood stasis, and tonifying yin and relieving epigastric distention, and fundamentally improves the curative effect on the reflux esophagitis.

Detailed Description

In the present invention, the weight part of the scutellaria baicalensis is preferably 18 to 32 parts, and more preferably 22 to 28 parts. 22-28. The scutellaria baicalensis is cold in nature and bitter in taste, enters lung channels, gallbladder channels, spleen channels, large intestine channels and small intestine channels, has the effects of clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding and preventing miscarriage, and belongs to heat-clearing and dampness-drying medicines classified under heat-clearing medicines.

In the present invention, the weight part of forsythia is preferably 18 to 23 parts, and more preferably 20 to 21 parts. The forsythia is slightly cold in nature and bitter in taste, enters lung channels, heart channels and small intestine channels, has the effects of clearing heat, removing toxicity, relieving swelling and dissipating stagnation, and belongs to heat-clearing and detoxifying drugs classified under heat-clearing drugs. It is indicated for abscess, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early epidemic febrile disease, high fever, polydipsia, coma, macula, stranguria and anuresis. Is antimicrobial; inhibiting phosphodiesterase, lipoxygenase; stopping vomiting; anti-liver damage; anti-inflammatory; inhibiting elastase activity; reduce spontaneous hypertension, etc.

In the invention, the honeysuckle is preferably 16-22 parts by weight, and more preferably 18-20 parts by weight. The honeysuckle flower is cold in nature and sweet in taste, belongs to lung channel, heart channel and stomach channel, has the effects of clearing heat, removing toxicity, cooling and dispersing wind heat, and belongs to heat-clearing and detoxifying medicines classified under heat-clearing medicines. It can be used for treating carbuncle, furuncle, pharyngitis, erysipelas, dysentery with bloody stool, wind-heat type common cold, epidemic febrile disease, and fever. The traditional Chinese medicine composition is prepared into various preparations clinically, and is used for treating throat inflammation, pulmonary tuberculosis complicated with respiratory tract infection, pneumonia and bacillary dysentery, surgical suppurative infection, cervical erosion and acute ophthalmic inflammation.

In the present invention, the weight part of corydalis tuber is preferably 14 to 21 parts, and more preferably 16 to 19 parts. The corydalis tuber is warm in nature, pungent and bitter in taste, enters liver channels and spleen channels, has the effects of promoting blood circulation, removing blood stasis, regulating qi and relieving pain, and belongs to the blood circulation-promoting analgesics classified under the blood circulation-promoting and blood stasis-removing medicines. Can be used for treating pain due to qi stagnation and blood stasis, dysmenorrhea, amenorrhea, abdominal mass, puerperal stagnation, traumatic injury, and hernia pain.

In the present invention, the weight part of the earthworm is preferably 13 to 22 parts, and more preferably 16 to 18 parts. The earthworm is cold in nature, salty in taste, enters liver channel, spleen channel and bladder channel, has the efficacies of clearing heat, arresting convulsion, dredging collaterals, relieving asthma and promoting urination, and belongs to wind-extinguishing and spasm-stopping medicines classified under liver-calming and wind-extinguishing medicines.

In the invention, the radix ophiopogonis is preferably 12-19 parts by weight, and more preferably 15-17 parts by weight. The dwarf lilyturf tuber is slightly cold in nature, sweet and slightly bitter in taste, belongs to yin tonics classified under deficiency tonics, and has the effects of nourishing yin, promoting the production of body fluid, moistening lung and clearing heart-fire, and belongs to heart meridian channels. It can be used for treating dry cough due to lung dryness, hematemesis, pulmonary abscess, asthenia, dysphoria, diabetes, fever, body fluid injury, dry throat, dry mouth, and constipation.

In the present invention, the weight portion of the fructus aurantii is preferably 11 to 18 portions, and more preferably 15 to 16 portions. The bitter orange is warm in nature, bitter, pungent and sour in taste, enters spleen channels and stomach channels, has the effects of regulating qi, relieving epigastric distention, activating stagnancy and relieving flatulence, and belongs to qi-regulating medicines. It can be used for treating qi stagnation in chest and hypochondrium, distention and pain, indigestion, phlegm and fluid retention, gastroptosis, uterine prolapse, and proctoptosis.

In the invention, the weight part of the dried orange peel is preferably 11-18 parts, and more preferably 15-16 parts. The dried orange peel is pungent, bitter and warm in taste, belongs to qi-regulating medicines, has the effects of regulating qi, stimulating appetite, eliminating dampness and phlegm, and treating spleen and stomach diseases, and belongs to the warm nature, and the dried orange peel enters spleen channels and lung channels. It is commonly used for treating fullness and distention in chest and abdomen, anorexia, vomiting, cough and profuse sputum.

In the invention, the weight part of the bupleurum is preferably 12 to 18 parts, and more preferably 15 to 17 parts. The bupleurum has slightly cold property and bitter taste, enters liver channel, gallbladder channel and lung channel, has the efficacies of relieving exterior and interior, soothing liver and invigorating yang, and belongs to the pungent-cool exterior-releasing herbs classified under exterior-releasing herbs. Can be used for treating common cold, fever, alternating chills and fever, distending pain in chest and hypochondrium, menoxenia, uterine prolapse, and proctoptosis.

In the present invention, the weight part of rhizoma Pinelliae Cordatae is preferably 9-14 parts, more preferably 12-13 parts. The rhizoma typhonii has pungent taste, warm nature and toxicity, belongs to the medicines for eliminating phlegm, relieving cough and asthma and belongs to the medicines for warming and resolving cold-phlegm in the category of the medicines for eliminating phlegm, relieving cough and relieving asthma, and the rhizoma typhonii enters lung channels and spleen channels, has the functions of eliminating dampness, resolving phlegm, relieving cough and reducing swelling. Can be used for treating cough with excessive phlegm, bronchitis, eliminating phlegm, relieving cough, stopping vomiting, inhibiting salivary secretion, inhibiting central nervous system, resisting oxidation, and purging.

In the invention, the weight part of the magnolia officinalis is preferably 8-14 parts, and more preferably 10-12 parts. The magnolia officinalis is warm in nature, bitter and pungent in taste, enters spleen channel, stomach channel, lung channel and large intestine channel, has the effects of eliminating dampness and dissolving phlegm, descending qi and relieving fullness, belongs to a dampness-resolving medicine, and can be used for treating damp stagnation impairment of middle-jiao, epigastric fullness, vomiting and diarrhea, dyspepsia, abdominal distension and constipation, phlegm-fluid retention and asthma and cough. Has muscle relaxation effect; small doses stimulate the smooth muscle of the intestinal tract, while large doses have an inhibitory effect; has antiulcer, central inhibition, blood pressure lowering, pathogenic microorganism resisting, and antitumor effects; it also has antiplatelet and intracellular calcium flow inhibiting effects.

In the present invention, the weight part of the atractylodes macrocephala koidz is preferably 10-14 parts, and more preferably 12-13 parts. The bighead atractylodes rhizome is warm in nature, sweet and bitter in taste, enters spleen channels and stomach channels, has the effects of strengthening spleen, tonifying qi, eliminating dampness and promoting diuresis, arresting sweating and preventing miscarriage, and belongs to qi tonics classified under deficiency tonifying medicines. It can be used for treating spleen and stomach qi deficiency, anorexia, listlessness, qi deficiency, diarrhea, phlegm retention, edema, jaundice, damp arthralgia, dysuresia, dizziness, spontaneous perspiration, and fetal irritability.

In the present invention, the dried ginger is preferably 5 to 8 parts by weight, more preferably 6 to 7 parts by weight. The dried ginger is hot in nature and pungent in taste, enters spleen channel, stomach channel, heart channel, kidney channel and lung channel, has the functions of warming middle-jiao and dispelling cold, restoring yang and dredging collaterals, and eliminating dampness and phlegm, and belongs to interior-warming medicines. Can be used for treating abdominal psychroalgia, cold limbs, slight pulse, phlegm retention, cough and asthma, gastrointestinal pain, colic, rheumatalgia, lumbago, leg pain, gastric and duodenal ulcer, acute bacillary dysentery, acute orchitis, ascariasis, intestinal obstruction, and chronic dyspepsia.

In the present invention, the platycodon root is preferably 5 to 7 parts by weight, and more preferably 6 parts by weight. The bitter and pungent taste, neutral in nature, entering lung meridian, mostly unprocessed, has the functions of dispersing lung qi, relieving sore throat, eliminating phlegm and discharging pus, and is commonly used for cough with excessive phlegm, chest distress, difficulty in smooth, pharyngalgia, hoarseness, lung carbuncle, hematemesis, pyocutaneous disease with pus formation and no ulceration. Honey platycodon root can strengthen the function of moistening lung to arrest cough and is mostly used for cough caused by lung yin deficiency.

In the present invention, the weight part of the licorice is preferably 4 to 6 parts, and more preferably 5 parts. The liquorice has mild nature and sweet taste, enters heart channel, stomach channel, spleen channel and lung channel, has the effects of tonifying spleen and qi, relieving cough and eliminating phlegm, relieving spasm and relieving pain and harmonizing drug properties, and belongs to qi-tonifying medicines classified under deficiency-tonifying medicines. Can be used for treating weakness of spleen and stomach, deficiency of middle-warmer energy, cough, asthma, carbuncle, sore, abdominal spasm, pain, and acute pain, and relieving drug toxicity. Unprocessed for clearing heat, and stir-baked for tonifying middle energizer.

In the invention, the weight part of the sweet osmanthus is preferably 3-7 parts, and more preferably 5-6 parts. The sweet osmanthus is warm in nature and pungent in taste, enters lung channel, spleen channel and kidney channel, has the effects of warming lung, resolving fluid retention, dispelling cold and relieving pain, and belongs to cold-phlegm warming and resolving medicines classified under phlegm-resolving, cough-relieving and asthma-relieving medicines. Can be used for treating phlegm retention cough and asthma, abdominal cold pain, intestinal wind and blood dysentery, amenorrhea dysmenorrhea, cold hernia abdominal pain, toothache, halitosis, etc.

In the present invention, the pulverized particle size is preferably 180 μm or less, more preferably 150 μm or less. In the present invention, the method for drying and pulverizing is not particularly limited, and a method for drying and pulverizing which is conventional in the art may be selected. In the present invention, the moisture content of the dried Chinese medicinal materials is preferably less than 9%, and more preferably less than 7%.

In the present invention, the oral preparation is preferably powder, syrup, tincture, solution, granule, tablet, capsule, pill or extract. The preparation method of the oral preparation is not particularly limited, and the oral preparation can be prepared according to a conventional preparation method in the field on the basis of ensuring the active ingredients of the traditional Chinese medicine composition.

The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating reflux esophagitis. The specific mode of the application is not particularly limited, and the application can be carried out according to the dosage form of the medicine by adopting the conventional administration mode of the medicines in the field.

In the invention, the raw materials, reagents and equipment are known products, and conventional commercial products can be adopted.

In order to further illustrate the present invention, the following technical solutions provided by the present invention are described in detail with reference to the examples, but they should not be construed as limiting the scope of the present invention.

Example 1

Taking 15 parts of scutellaria baicalensis, 15 parts of fructus forsythiae, 12 parts of honeysuckle, 12 parts of corydalis tuber, 10 parts of earthworm, 10 parts of radix ophiopogonis, 9 parts of fructus aurantii, 8 parts of dried orange peel, 8 parts of radix bupleuri, 7 parts of rhizoma pinelliae preparata, 5 parts of mangnolia officinalis, 5 parts of bighead atractylodes rhizome, 10 parts of dried ginger, 8 parts of platycodon grandiflorum, 8 parts of liquorice and 8 parts of sweet osmanthus, mixing, drying and crushing into fine powder of 180 mu m to obtain the traditional Chinese medicine composition.

Example 2

Taking 35 parts of scutellaria baicalensis, 25 parts of fructus forsythiae, 25 parts of honeysuckle, 25 parts of rhizoma corydalis, 26 parts of earthworm, 23 parts of radix ophiopogonis, 21 parts of fructus aurantii, 20 parts of pericarpium citri reticulatae, 20 parts of radix bupleuri, 16 parts of rhizoma pinelliae preparata, 18 parts of mangnolia officinalis, 18 parts of bighead atractylodes rhizome, 3 parts of rhizoma zingiberis, 4 parts of platycodon grandiflorum, 3 parts of liquorice and 2 parts of sweet osmanthus, mixing, drying and crushing into fine powder of 170 mu m to obtain the traditional Chinese medicine composition.

Example 3

Taking 28 parts of scutellaria baicalensis, 20 parts of fructus forsythiae, 20 parts of honeysuckle, 16 parts of rhizoma corydalis, 16 parts of earthworm, 17 parts of radix ophiopogonis, 16 parts of fructus aurantii, 15 parts of pericarpium citri reticulatae, 15 parts of radix bupleuri, 12 parts of rhizoma pinelliae preparata, 10 parts of mangnolia officinalis, 12 parts of bighead atractylodes rhizome, 6 parts of rhizoma zingiberis, 6 parts of platycodon grandiflorum, 5 parts of liquorice and 5 parts of sweet osmanthus, mixing, drying and crushing into fine powder of 150 mu m to obtain the traditional Chinese medicine composition.

Example 4

Animal experiments

1. Animals and groups

1.1 SD rats, mice weighing 200. + -.10 g, were selected for the experiment.

1.2 taking 50 rats and randomly dividing the rats into 5 groups, wherein each group comprises 10 rats which are respectively a negative control group, a positive control group, an example 1 group, an example 2 group and an example 3 group; wherein the negative control group was administered with distilled water, and the positive control group was administered with omeprazole at a dose of 3 mg/kg. Example 1 group was administered with 1g/kg of the Chinese medicinal composition described in example 1 of the present invention, example 2 group was administered with 1g/kg of the Chinese medicinal composition described in example 2 of the present invention, and example 3 group was administered with 1g/kg of the Chinese medicinal composition described in example 3 of the present invention.

2. Experimental methods

All rats are fasted for 24 hours without water prohibition, the abdomen is opened under ether anesthesia, the stomach and duodenum are exposed, the pylorus is tied, distilled water, omeprazole and the traditional Chinese medicine composition are respectively administered to the duodenum according to the above groups, the abdominal cavity is sutured, the rats are fasted for water prohibition, the rats are killed after 6 hours, gastric juice is collected, and the gastric juice amount is measured after centrifugal deslagging. Then, 0.2mL of gastric juice was taken and 1% phenolphthalein was added in 2 drops, the concentration of gastric acid was titrated with 0.02mol/l sodium hydroxide, and the flow rate of gastric acid was calculated, and the results are shown in Table 1.

Table 1 gastric acid results in various groups of rats

Group of	Amount of gastric juice/mL	Gastric acid concentration mmol/L	Gastric acid flow/mmol/6 h
				EXAMPLE 1 group	5.9±2.0	120±19.8	0.83±0.35
EXAMPLE 2 group	6.0±2.3	123±20.6	0.82±0.28
				EXAMPLE 3 group	5.8±2.2	122±21.3	0.85±0.21
Positive control group	6.1±1.8	128±20.3	0.88±0.36
				Negative controlGroup of	11.2±2.5	165±22.4	1.86±0.24

The traditional Chinese medicine composition provided by the invention has a good effect of treating reflux esophagitis, can be used for treating reflux esophagitis instead of western medicines, and has no side effect.

Example 5

Clinical application

100 men and women who are not limited to patients suffering from reflux esophagitis are randomly selected, all patients are diagnosed by RE, and have typical symptoms of heartburn, acid regurgitation and chest pain, and also can be accompanied by dyspepsia symptoms such as epigastric pain, gastrectasia, eructation, nausea and the like, or simultaneously accompanied by discomfort of throat, dysphagia and sleep disorder. Complications such as chronic cough, bronchial asthma, chronic laryngitis, dental erosion, upper gastrointestinal hemorrhage, and esophageal stenosis may also be present.

The Chinese medicinal composition of the embodiments 1 to 3 of the invention is taken with hot water, 3 times a day, 2 to 4g each time, and the curative effect is observed after half a month of taking, and the results are shown in table 2.

TABLE 2 Observation of the therapeutic effects

Wherein the therapeutic effect determination criteria are as follows:

and (3) curing: the typical symptoms of RE disappear, the complications disappear, and the mucosa at the joint of the stomach and the esophagus is normal through gastroscopy;

the effect is shown: the typical symptoms of RE are basically disappeared, the complications are obviously relieved or disappeared, mucosal ulcer at the junction of the stomach and the esophagus disappears, hyperemia and edema are relieved, and exudates are reduced;

the method has the following advantages: typical symptoms of RE are relieved, complications are relieved, and congestion and edema of gastric and esophageal mucosa are relieved;

and (4) invalidation: there was no significant improvement in the typical symptoms of RE, reduced or no improvement in complications, and no change in gastric and esophageal mucosa.

The above embodiments show that the traditional Chinese medicine composition for treating reflux esophagitis provided by the invention is reasonable in compatibility, has the effects of clearing heat, lowering adverse qi, promoting blood circulation, removing blood stasis and tonifying yin and relieving epigastric distention, and is proved by experiments that the composition can fundamentally improve the curative effect on reflux esophagitis, and the effective rate reaches 100%.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims

1. The traditional Chinese medicine composition for treating reflux esophagitis is characterized by comprising the following raw materials in parts by weight:

15-35 parts of scutellaria baicalensis, 15-25 parts of fructus forsythiae, 12-25 parts of honeysuckle, 12-25 parts of corydalis tuber, 10-26 parts of earthworm, 10-23 parts of radix ophiopogonis, 9-21 parts of fructus aurantii, 8-20 parts of dried orange peel, 8-20 parts of radix bupleuri, 7-16 parts of rhizoma pinelliae preparata, 5-18 parts of mangnolia officinalis, 5-18 parts of bighead atractylodes rhizome, 3-10 parts of dried ginger, 4-8 parts of platycodon grandiflorum, 3-8 parts of liquorice and 2-8 parts of sweet osmanthus flower.

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight:

18-32 parts of scutellaria baicalensis, 18-23 parts of fructus forsythiae, 16-22 parts of honeysuckle, 14-21 parts of corydalis tuber, 13-22 parts of lumbricus, 12-19 parts of radix ophiopogonis, 11-18 parts of fructus aurantii, 11-18 parts of pericarpium citri reticulatae, 12-18 parts of radix bupleuri, 9-14 parts of rhizoma pinelliae praeparata, 8-14 parts of mangnolia officinalis, 10-14 parts of bighead atractylodes rhizome, 5-8 parts of dried ginger, 5-7 parts of platycodon grandiflorum, 4-6 parts of liquorice and 3-7 parts of sweet osmanthus.

3. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight:

4. A method for preparing the traditional Chinese medicine composition of any one of claims 1 to 3, which is characterized by comprising the following steps:

mixing the traditional Chinese medicine raw materials of any one of claims 1-3 according to a weight part ratio, drying and crushing to obtain the traditional Chinese medicine composition.

5. The method of claim 4, wherein the pulverized particle size is 180 μm or less.

6. The preparation method of claim 4, wherein the water content of the dried Chinese medicinal materials is less than 9%.

7. An oral preparation for treating reflux esophagitis, comprising the Chinese medicinal composition according to any one of claims 1 to 3.

8. The oral formulation of claim 7, wherein the oral formulation is a powder, syrup, tincture, solution, granule, tablet, capsule, pill, or extract.

9. Use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of a medicament for the treatment of reflux esophagitis.