CN104491522A - Pharmaceutical composition for treating seborrheic dermatitis - Google Patents

Pharmaceutical composition for treating seborrheic dermatitis Download PDF

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CN104491522A
CN104491522A CN201410743341.8A CN201410743341A CN104491522A CN 104491522 A CN104491522 A CN 104491522A CN 201410743341 A CN201410743341 A CN 201410743341A CN 104491522 A CN104491522 A CN 104491522A
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parts
pharmaceutical composition
seborrheic dermatitis
rhizoma
medicine
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周连才
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周连才
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964Anemarrhena
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention belongs to the technical field of medicines and particularly relates to a pharmaceutical composition for treating seborrheic dermatitis. The pharmaceutical composition is prepared from the following components: fructus forsythia, apricot kernels, rhizoma anemarrhenae, lalang grass rhizome, dandelion, coptis chinensis, loquat leaf, root bark of white mulberry, scutellaria baicalensis and radix glycyrrhizae. The pharmaceutical composition disclosed by the invention is a Chinese herbal medicine, mature in preparation process, easily available in raw material, exact in curative effect for common seborrheic dermatitis, especially seborrheic dermatitis with syndrome of exuberant heat in lungs and stomachs, small in side effect, can be used for treating both manifestation and root cause of disease and effectively treating the seborrheic dermatitis.

Description

A kind of pharmaceutical composition for the treatment of seborrheic dermatitis
Technical field
The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of seborrheic dermatitis.
Background technology
Seborrheic dermatitis (Seborrheic Dermatitis), also known as seborrheic eczema, is the chronic inflammatory skin disease betiding seborrhea position.Primary disease is apt to occur in the abundant position of the sebaceous gland distribution such as head, face, breast and back, often limits to or starts from head, gradually spreading to other seborrhea positions such as face thoracic dorsals, serious can general whole body, even develop into erythroderma.Skin lesion is mainly red pityriasis rubra little pimple, kermesinus or yellowish red color patch, and be above covered with greasy scales or crust, severe patient can occur oozing out erosion, incrustation and alopecia in various degree, with pruritus in various degree.Be equivalent to the category of the traditional Chinese medical science " seborrhea ichthyosis " " seborrheic dermatitis ".
Primary disease is easy to diagnosis clinically, the state of an illness is easy to control, but tends to recurrence, not easily cures in a short time.Western medical treatment generally adopts the symptomatic treatments such as application androgen antagonist medicine, anti-inflammatory drug, and relapse rate is higher, and side effect is large.The traditional Chinese medical science has exuberant lung-stomach heat, stagnation of dampness due to deficiency of the spleen, blood-deficiency and wind-dry according to disease, and the traditional Chinese medical science can determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and determined curative effect, side effect is little, and the Chinese medicine composition for this reason studying effective treatment seborrheic dermatitis is very necessary.
Summary of the invention
The invention provides a kind of new pharmaceutical composition for the treatment of seborrheic dermatitis, this pharmaceutical composition is rapid-action, good effect, toxic and side effects is little, and it is obtained by following raw material: Fructus Forsythiae, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae, Rhizoma Imperatae, Herba Taraxaci, Rhizoma Coptidis, Folium Eriobotryae, Cortex Mori, Radix Scutellariae, Radix Glycyrrhizae.
In pharmaceutical composition of the present invention, described Fructus Forsythiae, bitter, be slightly cold.Return lung, the heart, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Semen Armeniacae Amarum is bitter; Temperature; Poisonous, return lung; Spleen; Large intestine channel, expelling phlegm for arresting cough; Relieving asthma; Intestine moistening; The therapeutic method to keep the adverse QI flowing downwards opens numbness.Main exogenous cough; Dyspnea with fullness of the chest; The cough due to dryness; Cold renal mass; Infantile convulsion; The thoracic obstruction; Stomachache due to dyspepsia; Metrorrhagia; Deaf; Infantile malnutrition with edema and abdominal distention; Damp-heat gonorrhoea; Scabies; Sore throat; Dryness of the intestine constipation.
The Rhizoma Anemarrhenae, bitter, sweet, cold.Return lung, stomach, kidney channel.Clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Rhizoma Imperatae, sweet, cold.Return lung, stomach, urinary bladder channel.Cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.
Herba Taraxaci, bitter, sweet, cold.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Rhizoma Coptidis, bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.
Folium Eriobotryae, bitter, be slightly cold.Attach to the lung and stomach meridians.Clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastric heat vomiting, dysphoria with smothery sensation is thirsty.
Cortex Mori, sweet, cold.Return lung meridian.Eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.
Radix Scutellariae is bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Radix Glycyrrhizae, sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
In pharmaceutical composition of the present invention, select the heat that Fructus Forsythiae pents up clearly, Semen Armeniacae Amarum is pungent to open damp-stagnancy, the Rhizoma Anemarrhenae is cold and cool rushes down stomach-fire clearly, and Rhizoma Imperatae clearing away heat and cooling blood is invigorated blood circulation, with Herba Taraxaci, Rhizoma Coptidis heat-clearing and toxic substances removing, let out clearly lung stomach two through lying prostrate fire, with Folium Eriobotryae, Cortex Mori, Radix Scutellariae clearing away lung-heat, dampness removing removing heat from blood; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, cushion toxicity.All medicines share, and complement each other, and play that removing heat from blood is moisturized, the effect of clearing away heat-damp and promoting diuresis altogether.
The technical scheme adopted for solving its technical problem is the pharmaceutical composition of described treatment seborrheic dermatitis, be made up of the medicine material of following weight: Fructus Forsythiae 6-16 part, Semen Armeniacae Amarum 1-5 part, Rhizoma Anemarrhenae 3-11 part, Rhizoma Imperatae 10-30 part, Herba Taraxaci 10-15 part, Rhizoma Coptidis 8-16 part, Folium Eriobotryae 6-12 part, Cortex Mori 10-20 part, Radix Scutellariae 3-11 part, Radix Glycyrrhizae 1-6 part.
The preferred technical solution of the present invention is, described pharmaceutical composition of the present invention is obtained by the raw material of following weight portion: Fructus Forsythiae 11 parts, 3 parts, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae 7 parts, Rhizoma Imperatae 20 parts, Herba Taraxaci 13 parts, Rhizoma Coptidis 12 parts, Folium Eriobotryae 9 parts, Cortex Mori 15 parts, Radix Scutellariae 7 parts, 3 parts, Radix Glycyrrhizae.
Present invention also offers the preparation method of described pharmaceutical composition, specifically comprise the steps:
The raw material Fructus Forsythiae of above-mentioned weight portion, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae, Rhizoma Imperatae, Herba Taraxaci, Rhizoma Coptidis, Folium Eriobotryae, Cortex Mori, Radix Scutellariae, Radix Glycyrrhizae powder are broken into coarse powder, mix homogeneously, add the soak by water 2 times of medical material gross mass 2 times amount, each 40 minutes, merge decoction liquor, filter, when filtrate is concentrated into 65 DEG C, its relative density is the concentrated solution of 1.16-1.20, places to add ethanol after 3 hours and make alcohol content be 65% of described whole raw material of Chinese medicine medicine, stirs evenly, place 12 hours, filter, reclaim ethanol, it is the thick paste of 1.31-1.36 that filtrate is concentrated into 65 DEG C of relative densities measured; Drying under reduced pressure or spraying dry, be ground into fine powder, to obtain final product.
Those skilled in the art directly can be used as medicine on obtained active constituents of medicine basis of the present invention to take or add on pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.As the oral drugs of the solid dosage form such as conventional tablet (dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, effervescent tablet), capsule (hard capsule, soft capsule), granule, pill (drop pill), powder can be made, the oral drugs of the liquid forms such as syrup, oral liquid, water preparation, mixture, decoction also can be made.Therefore, in this pharmaceutical composition except effective ingredient, pharmaceutically acceptable adjuvant can also be contained.Preferably, pharmaceutical composition of the present invention conveniently preparation technology be prepared into tablet, electuary, granule, capsule or powder etc.When using medicine composite for curing seborrheic dermatitis of the present invention to demonstrate,prove, take the electuary prepared by the present invention, granule or powder, each 5g, three times on the one, every gram of electuary, granule or powder are containing crude drug amount 0.5g.Take the tablet prepared by the present invention or capsule, each 5 or, three times on the one, every sheet or grain are containing crude drug amount 0.5g.
The present invention also asks to protect aforementioned pharmaceutical compositions in the purposes of preparation treatment seborrheic dermatitis particularly in preparation treatment lung and stomach excessive heat type seborrheic dermatitis medicine.By after the safety evaluatio of pharmaceutical composition of the present invention, after 2 courses for the treatment of of clinical observation treatment, total effects compares, and treatment group cure rate is 67.31%, and matched group is 30.77%, and cure rate compares, and the equal < 0.05 of P value, has significant difference; Total effective rate treatment group is 94.23%, and matched group is 67.30%, and total effective rate compares, and the equal < 0.05 of P value, has significant difference.On safety evaluatio, matched group occurs that 4 routine prurituss increase the weight of, and after drug withdrawal, pruritus is alleviated, and 2 routine skin lesion redden, and alleviate after drug withdrawal, treatment group has no obvious adverse reaction.Result shows that treatment group cure rate is obviously better than matched group, and two groups of total effective rates have significant difference.Illustrate that using medicine composite for curing seborrheic dermatitis of the present invention particularly to treat belongs to lung and stomach excessive heat type seborrheic dermatitis determined curative effect, safe and reliable, can be used as the effective ways for the treatment of lung and stomach excessive heat type seborrheic dermatitis, be worth promoting the use of in clinical.。Treatment group follows up a case by regular visits to half a year without recurrence simultaneously.Illustrate thus and to reach that removing heat from blood is moisturized, the object of clearing away heat-damp and promoting diuresis after pharmaceutical composition prescription of the present invention, serve the remarkable result for the treatment of both the principal and secondary aspects of a disease.
Pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, former medicine is easy to get, with low cost, follow the prescriptions principle of the traditional Chinese medical science, untoward reaction and side effect significantly reduce, and safety coefficient is high, verify through clinical practice, its determined curative effect, mild in medicine property and, there is not toxic and side effects and serious adverse reaction, clinical observation total effective rate reaches more than 90%, can treat seborrheic dermatitis particularly lung and stomach excessive heat type seborrheic dermatitis preferably.Medicine medication prepared by the present invention is simultaneously convenient, improves the compliance of patients with seborrheic dermatitis, improves the quality of life of patient.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
The each raw material of the present invention is taken: Fructus Forsythiae 11 parts, 3 parts, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae 7 parts, Rhizoma Imperatae 20 parts, Herba Taraxaci 13 parts, Rhizoma Coptidis 12 parts, Folium Eriobotryae 9 parts, Cortex Mori 15 parts, Radix Scutellariae 7 parts, 3 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology: by the raw material Fructus Forsythiae of above-mentioned weight portion, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae, Rhizoma Imperatae, Herba Taraxaci, Rhizoma Coptidis, Folium Eriobotryae, Cortex Mori, Radix Scutellariae, Radix Glycyrrhizae powder is broken into coarse powder, mix homogeneously, add the soak by water 2 times of medical material gross mass 2 times amount, each 40 minutes, merge decoction liquor, filter, when filtrate is concentrated into 65 DEG C, its relative density is the concentrated solution of 1.16-1.20, place and add ethanol after 3 hours and make alcohol content be 65% of described whole raw material of Chinese medicine medicine, stir evenly, place 12 hours, filter, reclaim ethanol, it is the thick paste of 1.31-1.36 that filtrate is concentrated into 65 DEG C of relative densities measured, drying under reduced pressure or spraying dry, be ground into fine powder.Those skilled in the art directly can be used as medicine on obtained active constituents of medicine basis of the present invention to take or add on pharmaceutics acceptable adjuvant routinely technique be prepared into the conventional oral formulations such as tablet, electuary, granule, capsule or powder.
When using medicine composite for curing seborrheic dermatitis of the present invention to demonstrate,prove, take the electuary prepared by the present invention, granule or powder, each 5g, three times on the one, every gram of electuary, granule or powder are containing crude drug amount 0.5g.Take the tablet prepared by the present invention or capsule, each 5 or, three times on the one, every sheet or grain are containing crude drug amount 0.5g.
Embodiment 2
The each raw material of the present invention is taken: Fructus Forsythiae 6 parts, 1 part, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae 3 parts, Rhizoma Imperatae 10 parts, Herba Taraxaci 10 parts, Rhizoma Coptidis 8 parts, Folium Eriobotryae 6 parts, Cortex Mori 10 parts, Radix Scutellariae 3 parts, 1 part, Radix Glycyrrhizae by following weight portion.
Embodiment 3
The each raw material of the present invention is taken: Fructus Forsythiae 16 parts, 5 parts, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae 11 parts, Rhizoma Imperatae 30 parts, Herba Taraxaci 15 parts, Rhizoma Coptidis 16 parts, Folium Eriobotryae 12 parts, Cortex Mori 20 parts, Radix Scutellariae 11 parts, 6 parts, Radix Glycyrrhizae by following weight portion.
Embodiment 4
The each raw material of the present invention is taken: Fructus Forsythiae 16 parts, 5 parts, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae 3 parts, Rhizoma Imperatae 10 parts, Herba Taraxaci 15 parts, Rhizoma Coptidis 16 parts, Folium Eriobotryae 6 parts, Cortex Mori 10 parts, Radix Scutellariae 11 parts, 6 parts, Radix Glycyrrhizae by following weight portion.
Embodiment 5
The each raw material of the present invention is taken: Fructus Forsythiae 6 parts, 1 part, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae 11 parts, Rhizoma Imperatae 30 parts, Herba Taraxaci 10 parts, Rhizoma Coptidis 8 parts, Folium Eriobotryae 12 parts, Cortex Mori 20 parts, Radix Scutellariae 3 parts, 1 part, Radix Glycyrrhizae by following weight portion.
The preparation technology of embodiment 2-5 is with embodiment 1.
The clinical data of embodiment 6 medicine composite for curing seborrheic dermatitis of the present invention
1, case-data: seborrheic dermatitis (lung and stomach excessive heat type) infant 104 the meeting inclusive criteria example selecting hospital outpatient to go to a doctor.The method of employing random packet, parallel control is studied.
Institute includes in the object of observation, treatment group: 52 examples, wherein man 23 example, female 29 example, age 18-53 year, 26.8 years old mean age ,-6 years January of the course of disease, average course of disease 1.5 years.Matched group: 52 examples, wherein man 25 example, female 27 example, age 18-52 year, 27.2 years old mean age ,-7 years January of the course of disease, average course of disease 1.4 years.Two groups of patient ages, sex, state of an illness distribution and other physical data compare there was no significant difference, have comparability.
2, diagnosis basis:
(1) Western medicine diagnose standard
(1) person between twenty and fifty are more common in.
(2) the densely distributed positions of sebaceous gland such as head, face, breast and back are betided well.
(3) from the beginning of being the little pimple of pityriasis rubra redness, can be fused into form yellowish red color not of uniform size or pink patch, coated with greasy scales or crust, boundary is clear, and sebum secretion increases.Severe patient can with oozing out erosion, thick crust and stink, and course of disease elder can with alopecia in various degree.
(4) conscious pruritus in various degree.
(5) course of disease is chronic, recurrent exerbation, time light time heavy.
(2) tcm diagnosis standard
(1) skin lesion place mostly is pale red or yellowish red color as coin shape patch, above covers greasy scales or crust.Seborrhea sicca goes out, common dry desquamation patch.Conscious pruritus.
(2) after being apt to occur in women's head-ornaments, nasolabial fold, ear, axillary fossa, upper breast, shoulder swell the seborrhea positions such as portion, omphalos and groin.
(3) many spiritednesses are easily excited, parasteatosis or have deviation food habit.
(3) TCM syndrome diagnostic criteria:
Exuberant lung-stomach heat: acute onset.Skin lesion color is red, and have ooze out, rotten to the corn, incrustation, play of itching.Companion's restlessness and thirst, constipation.Red tongue, yellow fur, slippery and rapid pulse.
3, inclusive criteria:
(1) seborrheic dermatitis Western medicine diagnose standard person is met;
(2) seborrheic dermatitis tcm diagnosis standard and lung and stomach excessive heat type disease standard person is met;
(3) age 18-60 year, male or female;
(4) the experimenter guardian person that signs Informed Consent Form.
4, exclusion standard:
(1) age less than 18, more than 60 years old person;
(2) gestation or women breast-feeding their children;
(3) the severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system are associated with, psychotic;
(4) corticosteroid hormone drug withdrawal for oral administration was less than 2 weeks, and external corticosteroid hormone or antihistaminic medicine for oral administration drug withdrawal were less than 1 week person;
(5) known maybe may to trial drug and component allergy sufferers thereof.
5, to reject and the standard that comes off:
(1), after case is selected in, find not meet inclusive criteria or meet exclusion standard person;
(2) there is serious adverse events, judge to stop this case clinical trial person according to doctor;
(3) case selected after data not entirely or not by specifying medication person.
6, usage and dosage:
Treatment group: take electuary prepared by the embodiment of the present invention 1, each 5g, three times on the one, every gram of electuary is containing crude drug amount 0.5g.
Matched group: viaminate capsule (the accurate word H21022962 of traditional Chinese medicines), usage: 25mg, oral, 3 times/day.
Within 2 weeks, be 1 course for the treatment of, two groups were all used in conjunction for 2 courses for the treatment of.
Treatments period, all gives up alcohol for two groups, and avoid seafood, beef and mutton and pungent stimulation food, keep pleasant emotion, Sufficient Sleeping.
7, efficacy evaluation:
(1) cure: skin lesion disappears, subjective symptoms disappears.
(2) take a turn for the better: skin lesion disappears more than 30%, and subjective symptoms alleviates.
(3) do not heal: symptom is unchanged, or improve less than 30%.
8, therapeutic effect:
Without coming off case in therapeutic process, all complete clinical observation.After 2 courses for the treatment of of two groups of patient treatments, total effects compares, and treatment group cure rate is 67.31%, and matched group is 38.46%, and cure rate compares, and P value < 0.05, has significant difference; Total effective rate treatment group is 94.23%, and matched group is 75.00%, and total effective rate compares, and P value < 0.05, has significant difference.On safety evaluatio, matched group occurs that 4 routine prurituss increase the weight of, and after drug withdrawal, pruritus is alleviated, and 2 routine skin lesion redden, and alleviate after drug withdrawal, treatment group has no obvious adverse reaction.From clinical trial results analysis, medicine composite for curing seborrheic dermatitis of the present invention is better than Viaminate, and two groups of total effective rates have significant difference.Use medicine composite for curing seborrheic dermatitis of the present invention particularly to treat and belong to lung and stomach excessive heat type seborrheic dermatitis determined curative effect, safe and reliable, can be used as the effective ways for the treatment of lung and stomach excessive heat type seborrheic dermatitis, be worth of widely use in clinical.
The comparitive study of table 1. treatment group and matched group

Claims (8)

1. treat the pharmaceutical composition of seborrheic dermatitis for one kind, it is characterized in that, it obtains primarily of the raw material of following weight portion: Fructus Forsythiae 6-16 part, Semen Armeniacae Amarum 1-5 part, Rhizoma Anemarrhenae 3-11 part, Rhizoma Imperatae 10-30 part, Herba Taraxaci 10-15 part, Rhizoma Coptidis 8-16 part, Folium Eriobotryae 6-12 part, Cortex Mori 10-20 part, Radix Scutellariae 3-11 part, Radix Glycyrrhizae 1-6 part.
2. pharmaceutical composition as claimed in claim 1, is characterized in that, it obtains primarily of the raw material of following weight portion: Fructus Forsythiae 11 parts, 3 parts, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae 7 parts, Rhizoma Imperatae 20 parts, Herba Taraxaci 13 parts, Rhizoma Coptidis 12 parts, Folium Eriobotryae 9 parts, Cortex Mori 15 parts, Radix Scutellariae 7 parts, 3 parts, Radix Glycyrrhizae.
3. pharmaceutical composition as claimed in claim 1 or 2, it is characterized in that, described pharmaceutical composition is oral formulations.
4. pharmaceutical composition as claimed in claim 3, it is characterized in that, described oral formulations is tablet, electuary, granule, capsule or powder.
5. pharmaceutical composition as claimed in claim 4, it is characterized in that, described oral formulations is electuary.
6. prepare the method for pharmaceutical composition as claimed in claim 1 or 2 for one kind, it is characterized in that, comprise the steps: the raw material Fructus Forsythiae of above-mentioned weight portion, Semen Armeniacae Amarum, the Rhizoma Anemarrhenae, Rhizoma Imperatae, Herba Taraxaci, Rhizoma Coptidis, Folium Eriobotryae, Cortex Mori, Radix Scutellariae, Radix Glycyrrhizae powder is broken into coarse powder, mix homogeneously, add the soak by water 2 times of medical material gross mass 2 times amount, each 40 minutes, merge decoction liquor, filter, when filtrate is concentrated into 65 DEG C, its relative density is the concentrated solution of 1.16-1.20, place and add ethanol after 3 hours and make alcohol content be 65% of described whole raw material of Chinese medicine medicine, stir evenly, place 12 hours, filter, reclaim ethanol, it is the thick paste of 1.31-1.36 that filtrate is concentrated into 65 DEG C of relative densities measured, drying under reduced pressure or spraying dry, be ground into fine powder, to obtain final product.
7. the purposes of pharmaceutical composition as claimed in claim 1 or 2 in preparation treatment seborrheic dermatitis medicine.
8. the purposes of pharmaceutical composition as claimed in claim 1 or 2 in preparation treatment lung and stomach excessive heat type seborrheic dermatitis medicine.
CN201410743341.8A 2014-12-06 2014-12-06 Pharmaceutical composition for treating seborrheic dermatitis Pending CN104491522A (en)

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