CN104998189A - Traditional Chinese medicine powder for treating infantile oral ulcer of wind-heat spleen type and preparation method thereof - Google Patents

Abstract

The present invention discloses a traditional Chinese medicine powder for treating infantile oral ulcer of wind-heat spleen type. The traditional Chinese medicine powder is prepared from the materials of tree peony bark, radix paeoniae rubrathe, golden cypress, herba taching, radices trichosanthis, Eucalyptus globulus Lab., honeysuckle, Dichocarpum auriculatum, forsythia, rhizoma curcumae longae, dahurian angelica root, smalltooth gomphostemma root, purslane, prepared radix glycyrrhizae, jackfruit, pineberry, Ligusticum wallichii, root, tschonosk trillium rhizome and flos daturae. The powder employs pure traditional Chinese medicines in appropriate compatibility, and is prepared by modern advanced medicine pharmaceutical technology, has the significant advantages of simultaneous treatment of principal and subordinate symptoms, rapid onset, effective alleviation of the suffering of patients, safety and no toxic or side effects. The traditional Chinese medicine powder is especially applicable to children, and effectively avoids the problems of drug resistance and toxicity caused by antibiotics in treatment.

Description

A kind of wind heat for the treatment of takes advantage of Chinese powder medicine of spleen type oral aphthae in children and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, particularly a kind of wind heat for the treatment of takes advantage of Chinese powder medicine of spleen type oral aphthae in children and preparation method thereof.

Background technology

There is yellow-white ulcer, pain sialorrhea with places such as gums, tongue body, two cheeks, palates in oral aphthae in children, or the heat that occurs together is feature.If ulcer area is comparatively large, above covers rotten rotten, be called erosion of the oral mucosa; Ulcer only occurs in lip both sides, is called swallow aphtha.Primary disease can occur separately, also can occur together among other diseases.Infant is comparatively common, prognosis bona.If have a delicate constitution, then aphtha occurs repeatedly, and delay is difficult.Modern medicine is thought, there is many pathogenic bacterium and non-pathogenic bacteria in human oral cavity.Under health condition, they and human body remain relative equilibrium, can not cause disease, once resistance of human body weakens, just oral cavity partial inflammation, ulcer can occur.If eat food overheated, really up to the mark to children's, or firmly excessive etc. when cleaning oral cavity of infant and children, all can lesion ports transmucosal and cause inflammation, fester.Children's suffers from respiratory tract infection, heating and by after antibacterial and viral infection, and oral cavity is unclean, and oral mucous membrane is dry, also can cause aphtha.High with underfed children's's sickness rate.Chinese medicine thinks primary disease mainly because retention of heat in the spleen and stomach, and hyperactivity of deficient fire is smoked and burnt dispute thus occur aphthous stomatitis.Common sympton is occur faint yellow or white aphtha face at places such as oral cavity epipharynx, tongue, buccal mucosa, gums, hard hips, single or multiple not etc., edge is neat and have blush, the pain of local, surface, has slight halitosis, excessive saliva and thickness, normal companion's dysphoria, be reluctant to take food, lean body mass, the symptoms such as heating.This disease of Chinese traditional treatment is particular about dialectical treatment, and one will distinguish deficiency and excess.Onset is anxious, and the course of disease is short, oral lesions and pain heavier, there is burning sensation local, or hot person of occurring together, and mostly is excess syndrome; Onset is delayed, and the course of disease is long, and oral lesions and pain comparatively the lighter, mostly is deficiency syndrome.Two will distinguish internal organs.On tongue, the tongue limit person of festering, belong to the heart more; Mouthful buccal, palate, gums bicker is festered is main person, belongs to taste more.In treatment, excess syndrome is controlled with heat-clearing and toxic substances removing; Deficiency syndrome are controlled with nourishing YIN to lower pathogenic fire, conducting fire back to its origin.Oral aphthae in children is divided into wind heat to take advantage of spleen type, type of flaming up of heart-fire and asthenic fire flaring up type three kinds of main Types by the traditional Chinese medical science, wherein, wind heat takes advantage of spleen type oral ulcer as a kind of common type, disease sees the speckle that festers that in words or cheek, the place such as gums and soft palate has yellow-white to differ in size, 1 ~ 2 at least, 5 ~ 6 at most, rounded or oval.Edge is micro-red, and pain can not be taken food and be occurred the symptoms such as agitation is thirsty, red urine, large dry stool, red tongue with yellow fur, thready and rapid pulse.Doctor trained in Western medicine adopts this disease of antibiotic therapy, antibiotic therapy costly, and easily develop immunity to drugs, reduce resistance of human body, comparatively major injury can be caused to the health of child, Chinese traditional treatment spininess is to the comprehensive conditioning human body of pathogenic root, but most method onset is comparatively slow, cannot rapid recovery patient suffering, especially child patient very easily produces to this long-term treatment means psychology of conflicting, mismatch treatment, affect the treatment.

Summary of the invention

The present invention improves prior art, in order to overcome the deficiency of existing treatment means, treatment wind heat is provided to take advantage of Chinese powder medicine of spleen type oral aphthae in children and preparation method thereof, this powder is pure Chinese medicinal preparation, child's use safety has no side effect, can rapid recovery patient affected part pain, promotes aphtha wound healing, treating both the principal and secondary aspects of a disease wind heat takes advantage of spleen type oral aphthae in children, evident in efficacy.

To achieve these goals, technical scheme provided by the invention is as follows:

Treat the Chinese powder medicine that wind heat takes advantage of spleen type oral aphthae in children, raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 6-8 part, Radix Paeoniae Rubra 7-10 part, Cortex Phellodendri 5-8 part, Folium Isatidis 7-10 part, Radix Trichosanthis 4-6 part, Eucalyptus globulus Labill 7-10 part, Flos Lonicerae 8-12 part, sow grass 5-7 part, Fructus Forsythiae 7-9 part, Rhizoma Curcumae Longae 6-8 part, Radix Angelicae Dahuricae 9-11 part, Radix Gomphostemmae 5-8 part, Herba Portulacae 10-13 part, Radix Glycyrrhizae Preparata 8-10 part, Fructus Artocarpi Heterophylli 7-9 part, Fructus Ananadis comosi certain kind of berries 10-12 part, Rhizoma Chuanxiong 6-8 part, Semen Momordicae 5-7 part, Rhizoma Trillii Tschonoskii 7-10 part, Flos Daturae 3-5 part.

Preferably, raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 6 parts, Radix Paeoniae Rubra 7 parts, Cortex Phellodendri 5 parts, Folium Isatidis 7 parts, Radix Trichosanthis 4 parts, Eucalyptus globulus Labill 7 parts, Flos Lonicerae 8 parts, sow grass 5 parts, Fructus Forsythiae 7 parts, 6 parts, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae 9 parts, Radix Gomphostemmae 5 parts, Herba Portulacae 10 parts, Radix Glycyrrhizae Preparata 8 parts, Fructus Artocarpi Heterophylli 7 parts, the Fructus Ananadis comosi certain kind of berries 10 parts, Rhizoma Chuanxiong 6 parts, Semen Momordicae 5 parts, Rhizoma Trillii Tschonoskii 7 parts, Flos Daturae 3 parts.

Preferably, raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 8 parts, Radix Paeoniae Rubra 10 parts, Cortex Phellodendri 8 parts, Folium Isatidis 10 parts, Radix Trichosanthis 6 parts, Eucalyptus globulus Labill 10 parts, Flos Lonicerae 12 parts, sow grass 7 parts, Fructus Forsythiae 9 parts, 8 parts, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae 11 parts, Radix Gomphostemmae 8 parts, Herba Portulacae 13 parts, Radix Glycyrrhizae Preparata 10 parts, Fructus Artocarpi Heterophylli 9 parts, the Fructus Ananadis comosi certain kind of berries 12 parts, Rhizoma Chuanxiong 8 parts, Semen Momordicae 7 parts, Rhizoma Trillii Tschonoskii 10 parts, Flos Daturae 5 parts.

Preferably, raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 7 parts, Radix Paeoniae Rubra 8 parts, Cortex Phellodendri 7 parts, Folium Isatidis 8 parts, Radix Trichosanthis 5 parts, Eucalyptus globulus Labill 8 parts, Flos Lonicerae 10 parts, sow grass 6 parts, Fructus Forsythiae 8 parts, 7 parts, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae 10 parts, Radix Gomphostemmae 7 parts, Herba Portulacae 11 parts, Radix Glycyrrhizae Preparata 9 parts, Fructus Artocarpi Heterophylli 8 parts, the Fructus Ananadis comosi certain kind of berries 11 parts, Rhizoma Chuanxiong 7 parts, Semen Momordicae 6 parts, Rhizoma Trillii Tschonoskii 8 parts, Flos Daturae 4 parts.

The invention also discloses and described a kind ofly treat the preparation method that wind heat takes advantage of the Chinese powder medicine of spleen type oral aphthae in children, comprise the following steps:

(1) Cortex Moutan, Radix Paeoniae Rubra, Cortex Phellodendri, Folium Isatidis, Radix Trichosanthis, Eucalyptus globulus Labill, Flos Lonicerae, Fructus Forsythiae, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) step (1) gained mixed-powder adds the distilled water immersion 1 hour of gross mass multiple 6 times, slow fire boiling 1 hour, and cross 500 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mix with Herba Portulacae, Radix Gomphostemmae, sow grass and clean, add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filter vacuum simmer down to original volume 10% concentrated solution, thickening temperature is lower than 45 DEG C;

(4) after the concentrated solution of step (3) gained being frozen into solid, be placed in vacuum freeze drier lyophilization, baking temperature is-25 ~-20 DEG C, pressure is-0.09 ~-0.08Mpa, gained drying solid super micron mill is pulverized, and gained powder is crossed 1000 mesh sieves and namely obtained the Chinese powder medicine that treatment wind heat takes advantage of spleen type oral aphthae in children.

Using method: this Chinese powder medicine is directly spread on affected part, 2 times on the one.

The present invention takes advantage of spleen type oral aphthae in children to treat wind heat, take the method for heat-clearing and toxic substances removing, anti-inflammation, promoting blood circulation and stopping pain, while take advantage of this disease of etiological treatment of spleen for wind heat, effective reduction of patient affected part pain, alleviate patient suffering fast, avoid child patient to produce psychology of conflicting, guarantee therapeutic effect.According to Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, screen raw material of Chinese medicine by great many of experiments, refining agent method, make each efficacy of drugs produce synergism, thus reach the effect for the treatment of both the principal and secondary aspects of a disease.In the crude drug chosen: Cortex Moutan: bitter, pungent, be slightly cold, GUIXIN, liver, kidney channel, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, for maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury; Radix Paeoniae Rubra: bitter, is slightly cold and returns Liver Channel, clearing away heat and cooling blood, eliminating stasis to stop pain, for maculae caused by violent heat pathogen, and hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, note of the ancient Chinese abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection; Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment; Folium Isatidis: heat clearing away, removing toxic substances, removing heat from blood, hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug; Radix Trichosanthis: clearing away heat and promoting production of body fluid, detumescence and apocenosis, for calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin; Eucalyptus globulus Labill: micro-pungent, the micro-hardship of taste, property is put down, and dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, anticorrosion antipruritic.For preventing influenza, epidemic cerebrospinal meningitis, control upper respiratory tract infection, pharyngolaryngitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery, filaricide, burn and scald is controlled in external, cellulitis, mastitis, furuncle and phyma, erysipelas, paddy-field dermatitis, skin eczema, tinea pedis, skin degerming; Flos Lonicerae: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease is generated heat; Sow grass: bitter in the mouth, cold in nature, removing damp-heat, detoxicating and resolving stagnation of pathogens, relieving cough and resolving phlegm, main jaundice due to damp-heat, carbuncle sore tumefacting virus, scrofula, phlegm-heat cough, epilepsy; Fructus Forsythiae: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens, modern medicine study confirms, Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.; Rhizoma Curcumae Longae: can circulation of qi promoting removing blood stasis with potent drugs, inducing menstruation to relieve menalgia, cures mainly chest and abdomen swelling and pain, shoulder arm arthralgia pain, unbearably pained, puerperal blood pain, skin ulcer tinea onset, menoxenia, amenorrhea, traumatic injury; The Radix Angelicae Dahuricae: expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping, profit blood vessels, expelling wind and cold, eliminating dampness and dredging channels, modern medicine study confirms, the Radix Angelicae Dahuricae all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.; Radix Gomphostemmae: bitter in the mouth, cool in nature, heat-clearing and toxic substances removing, relieving cough and resolving phlegm, antiinflammatory diuresis, controls pneumonia, tracheobronchitis, cough with copious phlegm, urinary tract infection, cystitis, oedema due to nephritis, lithangiuria; Herba Portulacae: cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Have that removing dampness is antipruritic, clearing heat for detumescence, heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, the effect of hemostasis removing heat from blood.Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ", simultaneously Herba Portulacae is also rich in vitamin C, and vitamin C has good antioxidation can whitening nourishes rough skin; Radix Glycyrrhizae Preparata: containing number of chemical compositions such as glycyrrhizin, enoxolone, Angelica Polysaccharide, there is antiinflammatory and anti-allergy action, scalable body's immunity, antitumor and analgesic effect, therefore the primary efficacy of Radix Glycyrrhizae Preparata is and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription; Fructus Artocarpi Heterophylli: have quench the thirst, lactogenesis, invigorating the spleen and replenishing QI effect, local blood circulation can be improved, to bronchitis, bronchial asthma, acute pneumonia, pharyngolaryngitis, retinitis, mastitis, puerperal engorgement of breasts, postpartum thrombophlebitis, arthritis, periarthritis, cellulitis, the disease such as ulcus cruris be all effective in cure, research finds that Fructus Artocarpi Heterophylli has antioxidation, antibacterial, antiinflammatory, adjunct antineoplastic, check melanin generate and the modern medicinal efficacy such as auxiliary hyperglycemic; The Fructus Ananadis comosi certain kind of berries: containing a kind of material being " Fructus Ananadis comosi proteinase ", Fructus Ananadis comosi proteinase can dissolve the effect of fibrin and the blood clot blocked in tissue, the blood circulation of local can be improved, diminish inflammation and edema, it is the plant that tanin content enriches, and the adsorbable absorption with stoping carcinogenic chemical, has protective effect on cancer risk in vivo, the carotene that it contains is the important substance of synthetic vitamin A, has improving eyesight nourishing the liver effect; Rhizoma Chuanxiong: pungent loose temperature is led to, can blood circulation promoting and blood stasis dispelling, again can promoting the circulation of QI to relieve pain, are " the gas medicine in blood ", the sensible QI and blood effect of tool, therefore control the breast side of body, all pains of abdominal part of qi depression to blood stasis; Semen Momordicae: dispersing swelling and dissipating binds, removing toxic substances, chases after wind pain relieving, main carbuncle, furuncle, innominate toxic swelling, hemorrhoid, tinea skin ulcer, acne, silent black, mastitis, tuberculous lymphadenitis, dysentery, rheumatic arthralgia, the contracture of muscle arteries and veins, gingival swelling and pain; Rhizoma Trillii Tschonoskii: sweet in the mouth is micro-pungent, warm in nature, hemostasis, analgesia, granulation promoting, except rheumatism, detumescence poison, controls traumatic hemorrhage, various lumbago, impairment caused by overstrain, traumatic injury, innominate toxic swelling; Flos Daturae: smooth-going cough-relieving, narcotic analgesic, spasmolytic is only jerked.

In all medicines, the Radix Angelicae Dahuricae, Herba Portulacae are monarch drug, take advantage of disease and the cause of disease of spleen type oral aphthae in children for wind heat, play the effect of heat-clearing and toxic substances removing, anti-inflammation, promoting blood circulation and stopping pain, this disease for the treatment of both the principal and secondary aspects of a disease, removing wind heat, kill while pathogenic bacterium effect a radical cure this disease, rapid recovery affected part pain, reduces patient suffering, Cortex Moutan, Radix Paeoniae Rubra, Cortex Phellodendri, Folium Isatidis, Radix Trichosanthis, Eucalyptus globulus Labill, Flos Lonicerae, sow grass, Fructus Forsythiae, Rhizoma Curcumae Longae, Radix Gomphostemmae, Rhizoma Chuanxiong, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae is ministerial drug, wherein, Eucalyptus globulus Labill, Fructus Forsythiae, Radix Gomphostemmae can the effect of gain monarch drug anti-inflammation, directly act on the effective antimicrobial therapy aphtha in affected part, Cortex Moutan, Radix Paeoniae Rubra, Cortex Phellodendri, Folium Isatidis, Radix Trichosanthis, Eucalyptus globulus Labill, Fructus Forsythiae, Radix Gomphostemmae, Flos Lonicerae, sow grass, Semen Momordicae can the effect of gain monarch drug heat-clearing and toxic substances removing, wind heat treatment aphtha is removed for the cause of disease, Cortex Moutan, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Semen Momordicae, Rhizoma Trillii Tschonoskii, Rhizoma Curcumae Longae, Flos Daturae can the effect of gain monarch drug promoting blood circulation and stopping pain, the swollen pain in rapid recovery affected part, alleviate patient suffering, Rhizoma Trillii Tschonoskii also has the effect of granulation promoting, affected part wound healing can be promoted, Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries are assistant, Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries not only can strengthen the anti-inflammation of monarch drug and ministerial drug, the effect of promoting blood circulation and stopping pain, also there is the effect improving local blood circulation simultaneously, the absorption of other drug effective ingredient can be increased, promote that the drug effect of other all medicines plays, Radix Glycyrrhizae Preparata for drawing, harmonizing yingfen and weifen, warming spleen and stomach for dispelling cold, simultaneously can gain monarch drug and ministerial drug anti-inflammation, heat-clearing and toxic substances removing effect, coordinating the actions of various ingredients in a prescription, better this disease for the treatment of.Medicine of the present invention is pure Chinese medicinal preparation, and selected medical material compatibility is suitable, and adopts modern advanced medical pharmaceutical technology to make, there is treating both the principal and secondary aspects of a disease rapid-action, can effectively reduction of patient to be painful, the remarkable advantage of safe without toxic side effect, is adapted to treatment wind heat being taken advantage of to spleen type oral aphthae in children.

Beneficial effect of the present invention is: the invention provides and a kind ofly treat the Chinese powder medicine that wind heat takes advantage of spleen type oral aphthae in children, take the method for heat-clearing and toxic substances removing, anti-inflammation, promoting blood circulation and stopping pain, while take advantage of this disease of etiological treatment of spleen for wind heat, effective reduction of patient affected part pain, alleviate patient suffering fast, avoid child patient to produce psychology of conflicting, guarantee therapeutic effect.Adopt pure Chinese medicinal preparation, selected medical material compatibility is suitable, and adopt modern advanced medical pharmaceutical technology to make, there is treating both the principal and secondary aspects of a disease rapid-action, can effectively reduction of patient be painful, the remarkable advantage of safe without toxic side effect, especially suitable child uses, and effectively prevent the drug resistance and toxic and side effects problem that adopt this disease of antibiotic medication to produce.

This Chinese powder medicine have employed the Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries that can improve and promote local blood circulation as adjuvant drug in the choosing of crude drug, by improving the sanguimotor method in coating position, accelerate local blood velocity, promote Transdermal absorption, make the effective ingredient of Transdermal absorption can arrive affected part with blood flow fast, promote curative effect of medication, Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries are as food grade materials, compared to conventional Percutaneous absorption enhancer as azone compounds, alcohol compound and dimethyl sulfoxide and homologue thereof, its to the stimulation of human body and toxic and side effects less, especially for child, use safer.

This Chinese powder medicine is in preparation process, crude drug is pulverized in advance and decocts again, add the contact area of crude drug and water, advantageously in the extraction of effective ingredient, crude drug can be made full use of, gained drug extract is dried in the air cool to room temperature again with Fructus Artocarpi Heterophylli, the mixing such as the Fructus Ananadis comosi certain kind of berries is squeezed the juice, effective ingredient in the medicines such as cold extraction Fructus Artocarpi Heterophylli, thereafter adopt and prepare this powder lower than the vacuum concentration of 45 DEG C and cryodesiccated means, the vitamins and other nutritious components in Fructus Artocarpi Heterophylli and effective ingredient can be effectively avoided to be subject to high temperature in leaching process, better guarantee drug effect.

Detailed description of the invention

According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only should can not limit the present invention described in detail in claims yet for illustration of the present invention.

Embodiment 1

Treat the Chinese powder medicine that wind heat takes advantage of spleen type oral aphthae in children, raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 6 parts, Radix Paeoniae Rubra 7 parts, Cortex Phellodendri 5 parts, Folium Isatidis 7 parts, Radix Trichosanthis 4 parts, Eucalyptus globulus Labill 7 parts, Flos Lonicerae 8 parts, sow grass 5 parts, Fructus Forsythiae 7 parts, 6 parts, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae 9 parts, Radix Gomphostemmae 5 parts, Herba Portulacae 10 parts, Radix Glycyrrhizae Preparata 8 parts, Fructus Artocarpi Heterophylli 7 parts, the Fructus Ananadis comosi certain kind of berries 10 parts, Rhizoma Chuanxiong 6 parts, Semen Momordicae 5 parts, Rhizoma Trillii Tschonoskii 7 parts, Flos Daturae 3 parts.

Described a kind ofly treat the preparation method that wind heat takes advantage of the Chinese powder medicine of spleen type oral aphthae in children, comprise the following steps:

(1) Cortex Moutan, Radix Paeoniae Rubra, Cortex Phellodendri, Folium Isatidis, Radix Trichosanthis, Eucalyptus globulus Labill, Flos Lonicerae, Fructus Forsythiae, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) step (1) gained mixed-powder adds the distilled water immersion 1 hour of gross mass multiple 6 times, slow fire boiling 1 hour, and cross 500 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mix with Herba Portulacae, Radix Gomphostemmae, sow grass and clean, add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filter vacuum simmer down to original volume 10% concentrated solution, thickening temperature is 40 DEG C;

(4) after the concentrated solution of step (3) gained being frozen into solid, be placed in vacuum freeze drier lyophilization, baking temperature is-25 ~-20 DEG C, pressure is-0.09 ~-0.08Mpa, gained drying solid super micron mill is pulverized, and gained powder is crossed 1000 mesh sieves and namely obtained the Chinese powder medicine that treatment wind heat takes advantage of spleen type oral aphthae in children.

Using method: this Chinese powder medicine is directly spread on affected part, 2 times on the one.

Embodiment 2

Treat the Chinese powder medicine that wind heat takes advantage of spleen type oral aphthae in children, raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 7 parts, Radix Paeoniae Rubra 8 parts, Cortex Phellodendri 7 parts, Folium Isatidis 8 parts, Radix Trichosanthis 5 parts, Eucalyptus globulus Labill 8 parts, Flos Lonicerae 10 parts, sow grass 6 parts, Fructus Forsythiae 8 parts, 7 parts, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae 10 parts, Radix Gomphostemmae 7 parts, Herba Portulacae 11 parts, Radix Glycyrrhizae Preparata 9 parts, Fructus Artocarpi Heterophylli 8 parts, the Fructus Ananadis comosi certain kind of berries 11 parts, Rhizoma Chuanxiong 7 parts, Semen Momordicae 6 parts, Rhizoma Trillii Tschonoskii 8 parts, Flos Daturae 4 parts.

The preparation method of described Chinese powder medicine is identical with embodiment 1 with using method.

Embodiment 3

Treat the Chinese powder medicine that wind heat takes advantage of spleen type oral aphthae in children, raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 8 parts, Radix Paeoniae Rubra 10 parts, Cortex Phellodendri 8 parts, Folium Isatidis 10 parts, Radix Trichosanthis 6 parts, Eucalyptus globulus Labill 10 parts, Flos Lonicerae 12 parts, sow grass 7 parts, Fructus Forsythiae 9 parts, 8 parts, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae 11 parts, Radix Gomphostemmae 8 parts, Herba Portulacae 13 parts, Radix Glycyrrhizae Preparata 10 parts, Fructus Artocarpi Heterophylli 9 parts, the Fructus Ananadis comosi certain kind of berries 12 parts, Rhizoma Chuanxiong 8 parts, Semen Momordicae 7 parts, Rhizoma Trillii Tschonoskii 10 parts, Flos Daturae 5 parts.

The preparation method of described Chinese powder medicine is identical with embodiment 1 with using method.

Embodiment 4 toxicity test

Experiment that this Chinese powder medicine carries out " acute oral toxicity once limit the quantity test method(s) ", chooses healthy adult mice, body weight 18-22g, 30, male and female half and half, must not exceed 10% of average weight with sex mice mesosome heavy phase difference.Experiment starts fasting in front 16h, then 3 groups are equally divided into arbitrarily with the administration of per os administration by gavage to adult mice, give the Chinese powder medicine of embodiment 1 to 3 respectively, gavage metering is with 80mg/Kg weighing machine, then fasting 3 days is continued, test mice overall health of patients, diet, drinking-water, body weight increase all normal, do not occur trembling, twitch, sialorrhea, diarrhoea, obviously intoxicating phenomenon and the phenomena of mortality such as drowsiness, stupor, place's post mortem Non Apparent Abnormality, judges that this medicine is to the nontoxic level in the true border of adult mice acute oral toxicity.

Embodiment 5 clinical trial:

Random selecting 400 wind heat take advantage of spleen type oral aphthae in children patient to carry out clinical trial, patient age 3 ~ 8 years old, average 5 years old, patient is divided into 4 groups at random, be respectively matched group, experiment A group, experiment B group, experiment C group, medication: Chinese powder medicine is directly spread on affected part, 2 times on the one.Each group of administrations is as follows:

Matched group: give to contrast Chinese powder medicine;

Experiment A group: the Chinese powder medicine giving the embodiment of the present invention 1;

Experiment B group: the Chinese powder medicine giving the embodiment of the present invention 2;

Experiment C group: the Chinese powder medicine giving the embodiment of the present invention 3;

Wherein, the raw material making contrast Chinese powder medicine consists of: Cortex Moutan 6 parts, Radix Paeoniae Rubra 7 parts, Cortex Phellodendri 5 parts, Folium Isatidis 7 parts, Radix Trichosanthis 4 parts, Eucalyptus globulus Labill 7 parts, Flos Lonicerae 8 parts, sow grass 5 parts, Fructus Forsythiae 7 parts, 6 parts, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae 9 parts, Radix Gomphostemmae 5 parts, Herba Portulacae 10 parts, Radix Glycyrrhizae Preparata 8 parts, Rhizoma Chuanxiong 6 parts, Semen Momordicae 5 parts, Rhizoma Trillii Tschonoskii 7 parts, Flos Daturae 3 parts.

The preparation method of described contrast Chinese powder medicine, comprises the following steps:

(1) Cortex Moutan, Radix Paeoniae Rubra, Cortex Phellodendri, Folium Isatidis, Radix Trichosanthis, Eucalyptus globulus Labill, Flos Lonicerae, Fructus Forsythiae, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) step (1) gained mixed-powder adds the distilled water immersion 1 hour of gross mass multiple 6 times, slow fire boiling 1 hour, and cross 500 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Herba Portulacae, Radix Gomphostemmae, sow grass mixing clean, add step (2) gained filtrate squeeze the juice after leave standstill 2 hours, cross 1000 filter screen filtration, gained filter vacuum simmer down to original volume 10% concentrated solution, thickening temperature is 40 DEG C;

(4) after the concentrated solution of step (3) gained being frozen into solid, be placed in vacuum freeze drier lyophilization, baking temperature is-25 ~-20 DEG C, pressure is-0.09 ~-0.08Mpa, gained drying solid super micron mill is pulverized, and gained powder is crossed 1000 mesh sieves and namely obtained the Chinese powder medicine that treatment wind heat takes advantage of spleen type oral aphthae in children.

Therapeutic process was a course for the treatment of with 3 days, and through the treatment of a course for the treatment of, evaluate the curative effect of each group of Chinese powder medicine, the standard of curative effect evaluation is:

Cure: all diseases of patient complete disappearance, rear three months without recurrence;

Take a turn for the better: patient condition is obviously alleviated, or disease disappears completely, but recur in three months;

Invalid: disease is unchanged or increase the weight of.

Statistical result is as follows:

	Matched group	Experiment A group	Experiment B group	Experiment C group
					Cure rate (%)	16	27	32	35
Improvement rate (%)	75	69	67	63
					Inefficiency (%)	9	4	1	2
Effective percentage (%)	91	96	99	98

Clinical exemplary embodiments:

1, Zhang, 3 years old, female, the speckle that festers that patient's soft palate place has 3 yellow-whites to differ in size, rounded, edge is micro-red, and pain can not be taken food, use the Chinese powder medicine treatment of the embodiment of the present invention 1, treatment affected part pain symptom on the same day is obviously alleviated, and after the course for the treatment of, heal in ulcer place, whole disease disappears, without recurrence in drug withdrawal three months.

2, Lee, 5 years old, man, the speckle that festers that tongue and the visible several yellow-white of maxillary differ in size, pain was obvious, and occur anorexia, agitation waits symptom, once treats by multiple method, still recurrent exerbation.Use the Chinese powder medicine treatment of the embodiment of the present invention 2, treatment affected part pain symptom on the same day was obviously alleviated, after the course for the treatment of, heal substantially in ulcer place, disease is obviously alleviated, two the course for the treatment of symptom all disappear, ulcer all healed, disease disappears completely, without recurrence in drug withdrawal three months.

3, bent certain, 8 years old, female, the speckle that festers that patient's tongue and soft palate place have multiple yellow-white to differ in size, ovalize, edge is micro-red, and pain can not be taken food, use the Chinese powder medicine treatment of the embodiment of the present invention 3, treatment pain symptom on the same day is obviously alleviated, and after the course for the treatment of, ulcer surface heals completely, whole disease disappears, without recurrence in drug withdrawal three months.

All patients during medication all without bad reflection, experimental result shows, treatment wind heat of the present invention takes advantage of the Chinese powder medicine of spleen type oral aphthae in children, can rapid recovery affected part pain, wound healing, evident in efficacy, safe and effective healing treatment wind heat can take advantage of spleen type oral aphthae in children, without recurrence after curing, it is desirable medicine.

Above embodiment is only for illustrating technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and to be implemented; can not limit the scope of the invention with this; all equivalences done according to spirit of the present invention change or modify, and all should be encompassed in protection scope of the present invention.

Claims (5)

1. treat the Chinese powder medicine that wind heat takes advantage of spleen type oral aphthae in children, it is characterized in that: raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 6-8 part, Radix Paeoniae Rubra 7-10 part, Cortex Phellodendri 5-8 part, Folium Isatidis 7-10 part, Radix Trichosanthis 4-6 part, Eucalyptus globulus Labill 7-10 part, Flos Lonicerae 8-12 part, sow grass 5-7 part, Fructus Forsythiae 7-9 part, Rhizoma Curcumae Longae 6-8 part, Radix Angelicae Dahuricae 9-11 part, Radix Gomphostemmae 5-8 part, Herba Portulacae 10-13 part, Radix Glycyrrhizae Preparata 8-10 part, Fructus Artocarpi Heterophylli 7-9 part, Fructus Ananadis comosi certain kind of berries 10-12 part, Rhizoma Chuanxiong 6-8 part, Semen Momordicae 5-7 part, Rhizoma Trillii Tschonoskii 7-10 part, Flos Daturae 3-5 part.

2. a kind ofly as claimed in claim 1 treat the Chinese powder medicine that wind heat takes advantage of spleen type oral aphthae in children, it is characterized in that: raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 6 parts, Radix Paeoniae Rubra 7 parts, Cortex Phellodendri 5 parts, Folium Isatidis 7 parts, Radix Trichosanthis 4 parts, Eucalyptus globulus Labill 7 parts, Flos Lonicerae 8 parts, sow grass 5 parts, Fructus Forsythiae 7 parts, 6 parts, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae 9 parts, Radix Gomphostemmae 5 parts, Herba Portulacae 10 parts, Radix Glycyrrhizae Preparata 8 parts, Fructus Artocarpi Heterophylli 7 parts, the Fructus Ananadis comosi certain kind of berries 10 parts, Rhizoma Chuanxiong 6 parts, Semen Momordicae 5 parts, Rhizoma Trillii Tschonoskii 7 parts, Flos Daturae 3 parts.

3. a kind ofly as claimed in claim 1 treat the Chinese powder medicine that wind heat takes advantage of spleen type oral aphthae in children, it is characterized in that: raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 8 parts, Radix Paeoniae Rubra 10 parts, Cortex Phellodendri 8 parts, Folium Isatidis 10 parts, Radix Trichosanthis 6 parts, Eucalyptus globulus Labill 10 parts, Flos Lonicerae 12 parts, sow grass 7 parts, Fructus Forsythiae 9 parts, 8 parts, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae 11 parts, Radix Gomphostemmae 8 parts, Herba Portulacae 13 parts, Radix Glycyrrhizae Preparata 10 parts, Fructus Artocarpi Heterophylli 9 parts, the Fructus Ananadis comosi certain kind of berries 12 parts, Rhizoma Chuanxiong 8 parts, Semen Momordicae 7 parts, Rhizoma Trillii Tschonoskii 10 parts, Flos Daturae 5 parts.

4. a kind ofly as claimed in claim 1 treat the Chinese powder medicine that wind heat takes advantage of spleen type oral aphthae in children, it is characterized in that: raw material composition and the parts by weight of making described Chinese powder medicine are: Cortex Moutan 7 parts, Radix Paeoniae Rubra 8 parts, Cortex Phellodendri 7 parts, Folium Isatidis 8 parts, Radix Trichosanthis 5 parts, Eucalyptus globulus Labill 8 parts, Flos Lonicerae 10 parts, sow grass 6 parts, Fructus Forsythiae 8 parts, 7 parts, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae 10 parts, Radix Gomphostemmae 7 parts, Herba Portulacae 11 parts, Radix Glycyrrhizae Preparata 9 parts, Fructus Artocarpi Heterophylli 8 parts, the Fructus Ananadis comosi certain kind of berries 11 parts, Rhizoma Chuanxiong 7 parts, Semen Momordicae 6 parts, Rhizoma Trillii Tschonoskii 8 parts, Flos Daturae 4 parts.

5. a kind of as described in Claims 1-4 treats the preparation method that wind heat takes advantage of the Chinese powder medicine of spleen type oral aphthae in children, it is characterized in that: comprise the following steps:

(1) Cortex Moutan, Radix Paeoniae Rubra, Cortex Phellodendri, Folium Isatidis, Radix Trichosanthis, Eucalyptus globulus Labill, Flos Lonicerae, Fructus Forsythiae, Rhizoma Curcumae Longae, the Radix Angelicae Dahuricae, Radix Glycyrrhizae Preparata, Rhizoma Chuanxiong, Semen Momordicae, Rhizoma Trillii Tschonoskii, Flos Daturae are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) step (1) gained mixed-powder adds the distilled water immersion 1 hour of gross mass multiple 6 times, slow fire boiling 1 hour, and cross 500 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mixes with Herba Portulacae, Radix Gomphostemmae, sow grass and cleans, add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filter vacuum simmer down to original volume 10% concentrated solution, thickening temperature is lower than 45 DEG C;

(4) after the concentrated solution of step (3) gained being frozen into solid, be placed in vacuum freeze drier lyophilization, baking temperature is-25 ~-20 DEG C, pressure is-0.09 ~-0.08Mpa, gained drying solid super micron mill is pulverized, and gained powder is crossed 1000 mesh sieves and namely obtained the Chinese powder medicine that treatment wind heat takes advantage of spleen type oral aphthae in children.