CN104997860A - Traditional Chinese medicine preparation for treating duodenal ulcer and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating duodenal ulcer. The traditional Chinese medicine preparation is prepared from the following medicinal materials: endoconcha sepiae, inula britannica chinensis, radix paeoniae alba, radix cynanchi paniculati, ligusticum wallichii, ciliatenerve knotweed root, japanese raspberry root, pericarpium juglandis, herba urariae crinitae, endothelium corneum gigeriae galli, chelidonium majus, caulis sargentodoxae and radix cynanchi atrati. The invention further discloses a preparation method of the traditional Chinese medicine preparation. With the adoption of the traditional Chinese medicine preparation provided by the invention for treating duodenal ulcer, the advantages that the curative effect is good, the cost is low, the cure rate is high and no adverse reaction is caused are achieved; besides, the condition of patients with duodenal ulcer can be rapidly relieved, the preparation process is simple and convenient, toxic and side effect is little, high easiness in preparation is achieved, the raw materials are inexpensive, the preparation method is simple, and large-scale application to clinical practices is facilitated.

Description

A kind of Chinese medicine preparation for the treatment of duodenal ulcer and preparation method thereof

Technical field

The present invention relates to a kind of medicinal preparation, particularly relate to a kind of Chinese medicine preparation being used for the treatment of duodenal ulcer and preparation method thereof.

Background technology

Duodenal ulcer is one of commonly encountered diseases in population of China, frequently-occurring disease, is the common type of peptic ulcer.Be apt to occur in the winter and spring that climate change is larger.Male's sickness rate is apparently higher than women.Abnormal with gastric acid secretion, helicobacter pylori (H.pylori) infects, NSAID (non-steroidal anti-inflammatory drug) (NSAID), live and diet is irregular, work and ambient pressure, smoking, drink and psychologic factors closely related.Duodenal ulcer mostly occurs at pyloric cap (95%), in the majority with antetheca, is secondly rear wall, lower wall, upper wall.After being commonly considered as the pessimal stimulation due to the cerebral cortex acceptance external world, cause harmonization of the stomach duodenum parietal vessel and muscle generation spasm, the resistance of gastrointestinal wall cytotrophy generation obstacle and gastrointestinal mucosa is reduced, cause gastrointestinal mucosa to be subject to Gastric juice digestion and form ulcer, someone thinks caused by cyrtosis bacillus infection at present, and ulcer is often single property, but also has multiple ulcer, harmonization of the stomach duodenal bulbar ulcer, claims combined Peptic Ulcer when existing simultaneously.

China treat at present duodenal ulcer normally drug administration to remove symptom and promote ulcer healing, although after Drug therapy, symptom can respite or disappearance, needs to take Western medicine in a large number while its recurrent exerbation, make patient suffer untold misery, the side effect produced health is very large.Although had the open source literature utilizing treatment by Chinese herbs urethritis at present, mostly can only play the object of alleviation, can not cure completely.

Summary of the invention

In order to solve the problem, the invention provides a kind of toxic and side effects little, there is splendid curative effect and the Chinese medicine preparation that cost is low, relapse rate is low to duodenal ulcer.

The technical solution used in the present invention is: a kind of Chinese medicine preparation for the treatment of duodenal ulcer, and each component of described Chinese medicine preparation is Endoconcha Sepiae, Flos Inulae, the Radix Paeoniae Alba, Radix Cynanchi Paniculati, Rhizoma Chuanxiong, Radix Aristolochiae Kaempferi, Radix Rubi Parvifolii, Exocarpium Juglandis Immaturum, Herba Urariae crinitae, Endothelium Corneum Gigeriae Galli, Herba Chelidonii.

Preferably, the ratio of weight and number of various component is, Endoconcha Sepiae 15-30 part, Flos Inulae 15-30, Radix Paeoniae Alba 10-20 part, Radix Cynanchi Paniculati 10-20 part, Rhizoma Chuanxiong 10-20 part, Radix Aristolochiae Kaempferi 10-20 part, Radix Rubi Parvifolii 10-20 part, Exocarpium Juglandis Immaturum 10-20 part, Herba Urariae crinitae 10-20 part, Endothelium Corneum Gigeriae Galli 5-15 part, Herba Chelidonii 5-15 part.

Preferred, the ratio of weight and number of various component is, Endoconcha Sepiae 15-20 part, Flos Inulae 15-20, Radix Paeoniae Alba 10-15 part, Radix Cynanchi Paniculati 10-15 part, Rhizoma Chuanxiong 10-15 part, Radix Aristolochiae Kaempferi 10-15 part, Radix Rubi Parvifolii 10-15 part, Exocarpium Juglandis Immaturum 10-15 part, Herba Urariae crinitae 10-15 part, Endothelium Corneum Gigeriae Galli 5-10 part, Herba Chelidonii 5-10 part.

Wherein, described Chinese medicine can also add Caulis Sargentodoxae and Radix Cynanchi Atrati, and described Caulis Sargentodoxae and the ratio of weight and number of Radix Cynanchi Atrati in described Chinese medicine are: Caulis Sargentodoxae 10-12 part, Radix Cynanchi Atrati 8-10 part.

Wherein, the dosage form of described Chinese medicine preparation is: sublimed preparation, powder, injection, plaster, syrup, oral liquid, suck agent, granule, sugar coated tablet, film coated tablet, capsule.

Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of described Chinese medicine is capsule, comprising:

The first step, Flos Inulae, the Radix Paeoniae Alba, Radix Cynanchi Paniculati are mixed in proportion, with being equivalent to alcohol reflux 3-5 time that mixture quality 3-4 determining alcohol is doubly 60-70%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 2-4 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.24-1.27, is dryly also ground into powder;

Second step, it is ethanol extraction 3-4 time of 80-90% by Radix Aristolochiae Kaempferi, Radix Rubi Parvifolii, Exocarpium Juglandis Immaturum, Herba Urariae crinitae determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 3-5 times amount, and static 2-4 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.24-1.27 and dry, pulverize powdered;

3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 1-2 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 4th step;

4th step, by above-mentioned powder and starch mixing, carry out pelletization treatment subsequently and drying, obtain compound particles, magnesium stearate is added again in compound particles, described magnesium stearate and described compound particles mass ratio are 0.25-100:0.5-100, obtain capsule 's content, are incapsulated in housing by described capsule 's content and namely obtain capsule.

Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of described Chinese medicine is injection, comprising:

The first step, Flos Inulae, the Radix Paeoniae Alba, Radix Cynanchi Paniculati are mixed in proportion, with being equivalent to alcohol reflux 3-5 time that mixture quality 3-4 determining alcohol is doubly 60-70%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 2-4 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.24-1.27, is dryly also ground into powder;

Second step, it is ethanol extraction 3-4 time of 80-90% by Radix Aristolochiae Kaempferi, Radix Rubi Parvifolii, Exocarpium Juglandis Immaturum, Herba Urariae crinitae determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 3-5 times amount, and static 2-4 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.24-1.27 and dry, pulverize powdered;

3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 1-2 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 4th step;

4th step, above-mentioned powder is mixed, being dissolved in quality is subsequently mixture 2-4 water doubly, the sodium hydroxide hydrotropy relative to powder quality 5%-15% is added under stirring, filter, to add concentration be the salt acid for adjusting pH value of 1mol/L is 5-6, filter, precipitate for subsequent use, filtrate passes through polyamide column, first wash decontamination with water, be the ethanol elution of 80-90% with determining alcohol subsequently, collect ethanol elution, precipitation determining alcohol is the ethanol extraction 2 times of 80-90%, filter, filtrate and above-mentioned eluent merge, reclaim ethanol, be evaporated to mastic and be spray dried to powder, the powder of acquisition is added relative to its quality 1-2 sodium chloride doubly and water for injection appropriate, the volume of needs is injected water to again further after dissolving, filter, embedding, sterilizing, obtain the injection needed.

Endoconcha Sepiae salty in the mouth, slightly warm in nature, enters liver, kidney channel, astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Main spitting blood, metrorrhagia, have blood in stool, epistaxis, wound hemorrhage, emission due to deficiency of the kidney spermatorrhea, leucorrhea with red and white discharge, stomachache are noisy, belch pantothenic acid, eczema ulcer.

Flos Inulae bitter in the mouth, pungent, salty, slightly warm in nature, returns lung, spleen, stomach, large intestine channel, sending down the abnormal ascending QI, expectorant, row water, preventing or arresting vomiting.For cough due to wind and cold, phlegm retention stores knot, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum, vomiting eructation, epigastric oppression and rigidity.

Radix Paeoniae Alba bitter in the mouth, acid, cold nature, returns liver, spleen channel, suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.

Radix Cynanchi Paniculati acrid in the mouth, warm in nature, return liver, stomach warp, removing dampness of dispeling the wind, antalgesic-antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, injury from falling down, urticaria, eczema.

Rhizoma Chuanxiong is warm in nature, can suppress multiple bacillus; Have antihistaminic and choleretic effect, pungent loose temperature is led to, and the pain relieving of energy dispelling wind and removing obstruction in the collateral, again can dispelling the wind and dampness pathogens arthralgia pain.

Radix Aristolochiae Kaempferi is cold in nature, and acrid in the mouth is bitter.Function with cure mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For enteritis, dysentery stomachache, gastric abscess, laryngopharynx swelling and pain, venom.Carbuncle furuncle and phyma pain, traumatic hemorrhage.Radix Rubi Parvifolii

Exocarpium Juglandis Immaturum bitter and puckery flavor, property is put down, can removing toxic substances and promoting subsidence of swelling, treat for stomachache and suffer from abdominal pain, dysentery of harnessing the river, control too fat to move sore.

Herba Urariae crinitae sweet and slightly bitter taste, property is put down, heat clearing away, removing toxic substances, hemostasis, eliminating carbuncle.Control cough, lung abscess, spit blood, spitting of blood, hematuria, proctoptosis, uterine prolapse, toxic swelling.

Endothelium Corneum Gigeriae Galli is sweet, taste is flat, returns spleen, stomach, small intestinal, urinary bladder channel, energy invigorating the stomach and promoting digestion, arresting seminal emission, and treating stranguria fossil, does not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of stranguria caused by urinary stone, gallbladder-distention hypochondriac pain.

Caulis Sargentodoxae bitter in the mouth, property are flat, return large intestine, Liver Channel, heat-clearing and toxic substances removing, invigorate blood circulation, dispel the wind.For abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, tumbling and swelling.

Radix Cynanchi Atrati bitter in the mouth, salty, cold in nature, return stomach, liver, kidney channel, function cures mainly clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment.For pathogenic warmth wound battalion heating, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, swollen ulcer drug.

Beneficial effect of the present invention:

Relative to the medicine being used for the treatment of duodenal ulcer of the prior art, adopt Chinese medicinal composition preparation of the present invention can gastric acid inhibitory, aid digestion, prevent from forming cicatrix and intestinal obstruction occurs, and dissipating blood stasis hemostasis, stomach function regulating relieve the pain, advantages such as duodenal ulcer, there is good effect, cost is low, cure rate is high, limitation is little, have no adverse reaction, and targeting is strong, energy is mitigate the disease rapidly, and toxic and side effects is little.The present invention is easy to use, and cheap, easy to use, can create good social value and economic interests.

Detailed description of the invention

Embodiment 1:

(1) treat a Chinese medicine for duodenal ulcer, formed by following raw material medicaments in part by weight proportioning:

Endoconcha Sepiae-20 parts, Flos Inulae 20, the Radix Paeoniae Alba 15 parts, Radix Cynanchi Paniculati 15 parts, Rhizoma Chuanxiong 10 parts, Radix Aristolochiae Kaempferi 10-part, Radix Rubi Parvifolii 10 parts, Exocarpium Juglandis Immaturum 10 parts, Herba Urariae crinitae 10 parts, Endothelium Corneum Gigeriae Galli 5 parts, Herba Chelidonii 5 parts.

(2) preparation method:

The first step, Flos Inulae, the Radix Paeoniae Alba, Radix Cynanchi Paniculati are mixed in proportion, with being equivalent to alcohol reflux 3-5 time that mixture quality 3-4 determining alcohol is doubly 60-70%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 2-4 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.24-1.27, is dryly also ground into powder;

Second step, it is ethanol extraction 3-4 time of 80-90% by Radix Aristolochiae Kaempferi, Radix Rubi Parvifolii, Exocarpium Juglandis Immaturum, Herba Urariae crinitae determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 3-5 times amount, and static 2-4 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.24-1.27 and dry, pulverize powdered;

3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 1-2 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 4th step;

4th step, by above-mentioned powder and starch mixing, carry out pelletization treatment subsequently and drying, obtain compound particles, magnesium stearate is added again in compound particles, described magnesium stearate and described compound particles mass ratio are 0.25-100:0.5-100, obtain capsule 's content, are incapsulated in housing by described capsule 's content and namely obtain capsule.

Embodiment 2:

(1) treat a Chinese medicine for duodenal ulcer, formed by following raw material medicaments in part by weight proportioning:

Endoconcha Sepiae-20 parts, Flos Inulae 20, the Radix Paeoniae Alba 15 parts, Radix Cynanchi Paniculati 15 parts, Rhizoma Chuanxiong 10 parts, Radix Aristolochiae Kaempferi 10-part, Radix Rubi Parvifolii 10 parts, Exocarpium Juglandis Immaturum 10 parts, Herba Urariae crinitae 10 parts, Endothelium Corneum Gigeriae Galli 5 parts, Herba Chelidonii 5 parts, Caulis Sargentodoxae 10 parts, Radix Cynanchi Atrati 8 parts.

(2) preparation method: with the preparation method of embodiment 1.

Embodiment 3:

(1) treat a Chinese medicine for duodenal ulcer, formed by following raw material medicaments in part by weight proportioning: with embodiment 1.

(2) preparation method:

The first step, Flos Inulae, the Radix Paeoniae Alba, Radix Cynanchi Paniculati are mixed in proportion, with being equivalent to alcohol reflux 3-5 time that mixture quality 3-4 determining alcohol is doubly 60-70%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 2-4 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.24-1.27, is dryly also ground into powder;

Second step, it is ethanol extraction 3-4 time of 80-90% by Radix Aristolochiae Kaempferi, Radix Rubi Parvifolii, Exocarpium Juglandis Immaturum, Herba Urariae crinitae determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 3-5 times amount, and static 2-4 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.24-1.27 and dry, pulverize powdered;

3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 1-2 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 4th step;

4th step, above-mentioned powder is mixed, being dissolved in quality is subsequently mixture 2-4 water doubly, the sodium hydroxide hydrotropy relative to powder quality 5%-15% is added under stirring, filter, to add concentration be the salt acid for adjusting pH value of 1mol/L is 5-6, filter, precipitate for subsequent use, filtrate passes through polyamide column, first wash decontamination with water, be the ethanol elution of 80-90% with determining alcohol subsequently, collect ethanol elution, precipitation determining alcohol is the ethanol extraction 2 times of 80-90%, filter, filtrate and above-mentioned eluent merge, reclaim ethanol, be evaporated to mastic and be spray dried to powder, the powder of acquisition is added relative to its quality 1-2 sodium chloride doubly and water for injection appropriate, the volume of needs is injected water to again further after dissolving, filter, embedding, sterilizing, obtain the injection needed.

Embodiment 4:

(1) treat a Chinese medicine for duodenal ulcer, formed by following raw material medicaments in part by weight proportioning: with embodiment 2.

(2) preparation method: with embodiment 3.

Embodiment 5:

1, acute toxicity test process:

Application ICR mice (Beijing Vital River Experimental Animals Technology Co., Ltd. provides) 60, body weight, at 25-30 gram, carries out acute toxicity testing.Mice is divided into three groups at random, i.e. matched group, administration 1 group, administration 2 groups, fasting 12 hours before experiment, then Chinese medicine capsules suspension of the present invention (be dissolved in water by capsule and the obtain suspension) gavage as embodiment 1 prepares is given, test determination is carried out to the median lethal dose(LD 50) (LD50) of administration, but has not measured LD ₅₀, because this has been mtd test.Result: with Cmax (60%), maximum dosage-feeding (120ml/kg, in one day, part gives for four times) 100g/kg gavage, be equivalent to crude drug amount 60g/kg, be equivalent to be grown up 300 times (by 75kg) of the daily dosage of clinical plan, in seven days mice none is dead, put to death each internal organs of mice anatomic observation and do not find toxic reaction, administration group with contrast 1,2 group of mice without any difference.

2, long term toxicity test process:

Experimental agents is set as high, medium and low three dosage by application Wistar rat (Beijing Vital River Experimental Animals Technology Co., Ltd. provides), is respectively capsule 8g/kg, 4g/kg, 2g/kg of embodiment 1 formula and capsule 8g/kg, 4g/kg, 2g/kg of embodiment 2 formula.Calculating with dosage 0.1g/kg/ sky-backing by people, is 80 times of people's effective dose, 40 times and 20 times respectively; Separately establish a matched group, continuous gastric infusion 90 days, 180 days and Some Animals drug withdrawal, after 10 days, observe the impact on the every physiology of rat, biochemical indicator.Experimental result shows: by various dose to rat continuous oral 180 days, increases all without affecting the food-intake of rat and body weight.Overt toxicity effect is not all found to hepatic and renal function.Obvious impact is showed no on routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc., between each group, compares no significant difference with matched group.

Embodiment 6:

Clinical treatment observation of the present invention is as follows:

(1) patient 200 example, wherein male 150 example, women 50 example.

(2) diagnostic criteria: with Ministry of Public Health " guideline of clinical investigations of new Chinese medicine treatment peptic ulcer " for reference, patient has the chronic epigastrium pain of the periodicity of prolonged and repeated outbreak, rhythmicity, epigastrium has limitation deeply in tenderness, X-ray canel barium meal contrast examination is shown in Ulcer niche, and endoscope's microscopy is as seen to active stage ulcer.

(3) Therapeutic Method: 1 group: adopt capsule 100g as obtained in embodiment 1 preparation method, be divided into 10 parts, every morning, (medicine) being taken before meal was a, within 30 days, was a course for the treatment of, took two courses for the treatment of continuously; 2 groups: adopt capsule 100g as obtained in embodiment 2 preparation method, be divided into 10 parts, every morning, (medicine) being taken before meal was a, within 30 days, was a course for the treatment of, took two courses for the treatment of continuously; 3 groups: adopt injection 100g as obtained in embodiment 3 preparation method, be divided into 10 parts, every morning injects portion on an empty stomach, within 30 days, is a course for the treatment of, injects two courses for the treatment of continuously; 4 groups: adopt injection 100g as obtained in embodiment 4 preparation method, be divided into 10 parts, every morning injects portion on an empty stomach, within 30 days, is a course for the treatment of, injects two courses for the treatment of continuously; Separately establish a matched group.

(4) efficacy assessment standard:

Cure: cardinal symptom and minor symptom all disappear, and gastroscopy ulcer disappears completely, local mild hyperaemia, but without obvious edema;

Take a turn for the better: primary symptom and secondary disease all have clear improvement, and gastroscopy ulcer disappears substantially, still have obvious inflammation or gastroscopy ulcer surface to reduce more than 50%;

Invalid: primary symptom and time disease are all without improving, and gastroscopy ulcer surface reduces not as good as 50%.

(5) therapeutic outcome

Group	Cure	Take a turn for the better	Invalid
				Matched group	0	0	40
1 group	31	4	5
				2 groups	35	3	2
3 groups	33	4	3
				4 groups	38	2	0

Above-described embodiment, just in order to technical conceive of the present invention and feature are described, its objective is and is one of ordinary skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.The change of every equivalence done by the essence of content of the present invention or modification, all should be encompassed in protection scope of the present invention.

Claims (7)

1. treat a Chinese medicine preparation for duodenal ulcer, it is characterized in that: each component of described Chinese medicine preparation is Endoconcha Sepiae, Flos Inulae, the Radix Paeoniae Alba, Radix Cynanchi Paniculati, Rhizoma Chuanxiong, Radix Aristolochiae Kaempferi, Radix Rubi Parvifolii, Exocarpium Juglandis Immaturum, Herba Urariae crinitae, Endothelium Corneum Gigeriae Galli, Herba Chelidonii.

2. Chinese medicine preparation as claimed in claim 1, is characterized in that: the ratio of weight and number of various component is Endoconcha Sepiae 15-30 part, Flos Inulae 15-30, Radix Paeoniae Alba 10-20 part, Radix Cynanchi Paniculati 10-20 part, Rhizoma Chuanxiong 10-20 part, Radix Aristolochiae Kaempferi 10-20 part, Radix Rubi Parvifolii 10-20 part, Exocarpium Juglandis Immaturum 10-20 part, Herba Urariae crinitae 10-20 part, Endothelium Corneum Gigeriae Galli 5-15 part, Herba Chelidonii 5-15 part.

3. Chinese medicine preparation as claimed in claim 1, is characterized in that: the ratio of weight and number of various component is Endoconcha Sepiae 15-20 part, Flos Inulae 15-20, Radix Paeoniae Alba 10-15 part, Radix Cynanchi Paniculati 10-15 part, Rhizoma Chuanxiong 10-15 part, Radix Aristolochiae Kaempferi 10-15 part, Radix Rubi Parvifolii 10-15 part, Exocarpium Juglandis Immaturum 10-15 part, Herba Urariae crinitae 10-15 part, Endothelium Corneum Gigeriae Galli 5-10 part, Herba Chelidonii 5-10 part.

4. the Chinese medicine preparation according to any one of claim 1-3, is characterized in that, described Chinese medicine can also add Caulis Sargentodoxae and Radix Cynanchi Atrati, and described Caulis Sargentodoxae and the ratio of weight and number of Radix Cynanchi Atrati in described Chinese medicine are: Caulis Sargentodoxae 10-12 part, Radix Cynanchi Atrati 8-10 part.

5. according to any one of claim 1-4, treat the Chinese medicine preparation of duodenal ulcer, it is characterized in that, the dosage form of described Chinese medicine preparation is: sublimed preparation, powder, injection, plaster, syrup, oral liquid, suck agent, granule, sugar coated tablet, film coated tablet, capsule.

6. according to any one of claim 1-4, treat a preparation method for the Chinese medicine preparation of duodenal ulcer, it is characterized in that: when the dosage form of described Chinese medicine is capsule, comprising:

The first step, Flos Inulae, the Radix Paeoniae Alba, Radix Cynanchi Paniculati are mixed in proportion, with being equivalent to alcohol reflux 3-5 time that mixture quality 3-4 determining alcohol is doubly 60-70%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 2-4 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.24-1.27, is dryly also ground into powder;

Second step, it is ethanol extraction 3-4 time of 80-90% by Radix Aristolochiae Kaempferi, Radix Rubi Parvifolii, Exocarpium Juglandis Immaturum, Herba Urariae crinitae determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 3-5 times amount, and static 2-4 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.24-1.27 and dry, pulverize powdered;

3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 1-2 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 4th step;

4th step, by above-mentioned powder and starch mixing, carry out pelletization treatment subsequently and drying, obtain compound particles, magnesium stearate is added again in compound particles, described magnesium stearate and described compound particles mass ratio are 0.25-100:0.5-100, obtain capsule 's content, are incapsulated in housing by described capsule 's content and namely obtain capsule.

7. the preparation method of the Chinese medicine preparation of duodenal ulcer according to any one of claim 1-4, is characterized in that: when the dosage form of described Chinese medicine is injection, comprising:

The first step, Flos Inulae, the Radix Paeoniae Alba, Radix Cynanchi Paniculati are mixed in proportion, with being equivalent to alcohol reflux 3-5 time that mixture quality 3-4 determining alcohol is doubly 60-70%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 2-4 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.24-1.27, is dryly also ground into powder;

Second step, it is ethanol extraction 3-4 time of 80-90% by Radix Aristolochiae Kaempferi, Radix Rubi Parvifolii, Exocarpium Juglandis Immaturum, Herba Urariae crinitae determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 3-5 times amount, and static 2-4 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.24-1.27 and dry, pulverize powdered;

3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 1-2 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 4th step;

4th step, above-mentioned powder is mixed, being dissolved in quality is subsequently mixture 2-4 water doubly, the sodium hydroxide hydrotropy relative to powder quality 5%-15% is added under stirring, filter, to add concentration be the salt acid for adjusting pH value of 1mol/L is 5-6, filter, precipitate for subsequent use, filtrate passes through polyamide column, first wash decontamination with water, be the ethanol elution of 80-90% with determining alcohol subsequently, collect ethanol elution, precipitation determining alcohol is the ethanol extraction 2 times of 80-90%, filter, filtrate and above-mentioned eluent merge, reclaim ethanol, be evaporated to mastic and be spray dried to powder, the powder of acquisition is added relative to its quality 1-2 sodium chloride doubly and water for injection appropriate, the volume of needs is injected water to again further after dissolving, filter, embedding, sterilizing, obtain the injection needed.