CN105477201A - Traditional Chinese medicine preparation for treating influenza and preparation method of traditional Chinese medicine preparation for treating influenza - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating influenza and a preparation method of the traditional Chinese medicine preparation for treating influenza. The traditional Chinese medicine preparation for treating influenza is characterized by being prepared from, by weight, 15 parts of herba corydalis bungeanae, 20 parts of folium isatidis, 35 parts of radix isatidis, 15 parts of honeysuckle, 15 parts of radix astragali, 20 parts of fructus forsythiae, 20 parts of radix platycodi, 35 parts of herba taraxaci, 20 parts of rhizoma et radix polygoni cuspidati, 20 parts of radix scrophulariae, 10 parts of radix glycyrrhizae, 20 parts of herba houttuyniae and 20 parts of herba artemisiae apiaceae. Due to property complementation of raw medicinal materials, mutual inhibition, mutual restraint and mutual detoxication in compatibility of the raw medicinal materials are avoided, and remarkable functions of mutual promotion and mutual enhancement are achieved. The traditional Chinese medicine preparation for treating influenza has efficacies of heat clearing, detoxifying, inflammation resisting, sterilizing, swelling relieving and heat dissipating and is a pure orally-taken herbal medicine preparation for treating influenza.

Description

Treat grippal Chinese medicine preparation and preparation method

Technical field

The present invention relates to field of traditional Chinese, be specifically related to one and be used for the treatment of grippal Chinese medicine preparation and preparation method, there is effect of heat-clearing and toxic substances removing, antiinflammatory sterilization, detumescence heat radiation, have positive effect for the anxious influenzas such as high heat, overall pain, significantly weak and slight respiratory tract that rise.

Background technology

Influenza (abbreviation influenza) is the acute respiratory infection that influenza virus causes, and is also the disease that a kind of infectiousness is strong, spread speed is fast.It is mainly through the spittle in air, interpersonal contact or the contact transmission with contaminated article.Typical clinical symptoms is: anxious high heat, overall pain, significantly weak and slight respiratory symptom.General autumn and winter season is its high-incidence season, and caused complication and the phenomena of mortality are very serious.This disease is caused by influenza virus, and can be divided into first (A), second (B), third (C) three type, Alphavirus often antigenic variation occurs, and infectiousness is large, propagates rapidly, very easily occurs popular on a large scale.H1N1 i.e. A type one.Primary disease has self limiting, but causes death at the severe complication such as infant, old people and the easy Complicating Pneumonia In Patients of patient that there is cardiopulmonary underlying diseases.Clinical manifestation: 1. incubation period: be generally 1 ~ 7 day incubation period, majority is 2 ~ 4 days.2. show: (1) simple type influenza: normal onset suddenly, the high heat of fear of cold, body temperature can reach 39 DEG C ~ 40 DEG C, the General Symptoms such as many companioned with headache, whole-body muscle joint aches, extremely weak, loss of appetite, often there are throat pain, dry cough, can have after nasal obstruction, watery nasal discharge, breastbone uncomfortable etc.Blushing, eye conjunctiva outer canthus mild hyperaemia.(2) pneumonic influenza: the viral pneumonia that has been exactly concurrent in fact.Main manifestations is that high heat is persistent, violent cough, hemoptysis expectorant or purulent sputum, rapid breathing, cyanosis, pulmonary's audible and wet sound of vomiting sound.Rabat points out two lungs to have the patchy shadow be dispersed in.Sputum culturing grows without malignant bacteria, separable go out influenza virus.Can be dead because of respiratory and circulatory failure.(3) toxic type influenza: show as the serious symptoms such as high heat, shock, respiratory failure, central nervous system damage and disseminated inravascular coagulation (DIC), case fatality rate is high.(4) gastrointestinal type influenza is except heating, and to vomit, to suffer from abdominal pain, to suffer from diarrhoea into distinguishing feature, child is more than adult.Within 2 ~ 3 days, can recover.(5) special population influenza: clinical manifestation is child's influenza 2. old people's influenza 3. gravid woman's influenza 4. immunodeficiency crowd influenza 1..

Summary of the invention:

One is the object of the present invention is to provide to be used for the treatment of grippal Chinese medicine preparation and preparation method, there is effect of heat-clearing and toxic substances removing, antiinflammatory sterilization, detumescence heat radiation, have positive effect for the anxious influenzas such as high heat, overall pain, significantly weak and slight respiratory tract that rise.

Present invention employs following technical scheme for achieving the above object: the medical material that Chinese medicine preparation of the present invention is selected and weight portion respectively: Herba Violae 15 parts, Folium Isatidis 20 parts, Radix Isatidis 35 parts, Flos Lonicerae 15 parts, the Radix Astragali 15 parts, Fructus Forsythiae 20 parts, Radix Platycodonis 20 parts, Herba Taraxaci 35 parts, Rhizoma Polygoni Cuspidati 20 parts, Radix Scrophulariae 20 parts, 10 parts, Radix Glycyrrhizae, Herba Houttuyniae 20 parts, Herba Artemisiae Annuae 20 parts.

In the raw material of Chinese medicine that the present invention selects: Herba Violae: cold in nature, bitter in the mouth, mild toxicity [return through]: " plateau Chinese herbal treatment handbook ": " enter the heart, spleen channel." [curative effect of medication] has the effect of heat-clearing and toxic substances removing, promoting blood circulation and detumescence.There is heat-clearing toxin-expelling functions.Cure mainly: influenza; Upper respiratory tract infection, tonsillitis; The high heat of epidemic febrile disease is irritated, influenza, infectious hepatitis, and intestinal is scorching; Nephritis, dysentery; Scrofula, conjunctivitis; Parotitis, acute appendicitis; Furuncle and other pyogenic infection; [chemical composition]: containing more than 10 kinds of alkaloids.From wherein obtaining Herba Corydalis Bungeanae A prime, B prime, C prime and D prime (temporary name) 4 kinds of different alkaloids.Another containing Coumarins lactone, steroid saponin, phenolic substance, resinene and volatilization wet goods;

Folium Isatidis: heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.

Radix Isatidis: Isatis indigotica Fort. root contains indigo, indirubin, Anthraquinones, cupreol, clionasterol and several amino acids: arginine, glutamic acid, tyrosine, proline, valine, γ-aminobutyric acid.Also containing potassium myronate, indigo glycoside, couroupitine A, 1-Hydrogen thiocyanate-2-hydroxyl fourth-3-alkene, sucrose and containing 12% amino acid whose proteoglycan.[effect] heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.[curing mainly] maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.

Flos Lonicerae: [meridian distribution of property and flavor] sweet in the mouth; Cold.Return lung; Stomach warp.Cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.

The Radix Astragali: have 1, an exterior deficiency spontaneous perspiration, is used for the weak caused spontaneous perspiration of body void table.2, night sweat due to yin deficiency; 3, acute nephritis edema, for the void edema caused by YANG QI deficiency; 4, oedema due to chronic nephritis, spleen person who suffer from deficiency of kidney Yang; 5, yang-energy is weak, caves in, have and promote diabrosis and limitation effect for skin infection not diabrosis for a long time.6, skin infection is burst for a long time and is not healed, and after skin infection diabrosis, does not close up for a long time, has the effect of promoting tissue regeneration and wound healing; 7, syndrome of deficiency of spleen qi, weak asthenia, has loose bowels, sinking of QI of middle-JIAO, and internal organs prolapse, the indigestion and loss of appetite all diseases of lack of appetite.8, syndrome of deficiency of lung qi.With the passing of time, shortness of breath and tired spirit, expectorant harmony brings up in lung is unable cough with asthma.9, hyperhidrosis and edema.10, weak for the deficiency of vital energy, fatigue and weakness, or sinking of QI of middle-JIAO, proctoptosis, uterine prolapse.Nature and flavor: sweet, tepor.Gui Jing: return lung, spleen, liver, kidney channel; Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.

Fructus Forsythiae: [chemical composition] fruit is containing forsythol, sterol compound, Saponin (without hemolytic) and Flavonoids, horse tongue resinol glycoside etc.Antibacterial action Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens, has the title of " persons particularly liable to develop skin infection's panacea ".Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction, clearing away heart-fire.

Radix Platycodonis: bitter in the mouth, pungent, slightly warm in nature.Enter lung meridian.Energy expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect.[effect]: lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.[curing mainly]: cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.

Herba Taraxaci: [nature,taste and action]: sweet, micro-hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.[curing mainly]: upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder assists inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.Containing taraxasterol (Taraxasterol), choline (Choline), inulin (Inulin), pectin (Pectin); Taraxol (Taraxol), stigmasterol (Stigmasterol), β-Amyrin (β-Amyrin), cupreol (β-Sitosterol), taraxerol (taraxerol), taraxacin (Taraxacerin), taraxacin (Taraxacin) and vitamin A, B, C etc.

Rhizoma Polygoni Cuspidati: [nature and flavor with return through] micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian.[function with cure mainly] heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.

Radix Scrophulariae: [meridian distribution of property and flavor]: sweet in the mouth, hardship, salty; Cold nature.Return lung, stomach, kidney channel.[effect]: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.Cure mainly: epidemic febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency not awake, Tianjin hinder constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore.

Radix Glycyrrhizae: property is put down, sweet in the mouth.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Chemical composition: Radix Glycyrrhizae contains number of chemical composition, and main component has glycyrrhizic acid, liquiritin etc.From Radix Glycyrrhizae, isolated compound has the tens of kinds of compounds such as glycyrrhizin, enoxolone, liquiritin, isoliquiritin, neoliquriitin, neoisoliquiritin, glycyrrhizin, isoliquiritigenin and licoricidin (+)-Licoricidin., glycyrol, isoglycyrol, 7-methylcoumarin essence, umbelliferone.

Herba Houttuyniae: cough vomiting bloody pus and cough due to lung-heat for lung abscess, expectorant is yellow and thick etc.These product are for controlling the key medicine of lung abscess.Cure mainly: lung abscess vomiting pus; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.Control pneumonia, lung abscess, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.

Herba Artemisiae Annuae: [nature and flavor with return through]: bitter, pungent, cold.Return liver, gallbladder meridian, three burnt, kidney channels.Function with cure mainly: clear deficiency-heat thoroughly, removing heat from blood except steaming, expelling summer-heat, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.

Raw medicinal material property of medicine effect selected by the present invention is complementary, evade the choosing of the mutual inhibition of compatibility between medicine, mutual restraint between two drugs, the mutual-detoxication, making medicine mutual reinforcement between, mutual-assistance effect significantly, have heat-clearing and toxic substances removing, antiinflammatory sterilization, detumescence heat radiation function, is that the grippal pure Chinese herbal medicine for oral administration for the treatment of forms preparation.There is during clinical practice good precise effects.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.Such as these crude drug pulverize mix homogeneously powder can be taken after mixing it with water; Can by these crude drug together decocting, then concentrated decocting liquid is taken, or concentrated decocting liquid is condensed into cream is processed into pill and takes; In order to make each raw material of this medicine play drug effect better, carry out special extraction for certain crude drug, as ethanol extraction, these can not be used for limiting the scope of the invention.

Medicine of the present invention has heat-clearing and toxic substances removing, antiinflammatory sterilization, detumescence heat radiation function, is used for the treatment of influenza.The present inventor through repeatedly studying, and passes through the checking repeatedly of clinical trial, finally have found the endo-medicine of better curative effect, thus completes the present invention.

Basic document:

Utilize the grippal Chinese medicine preparation for the treatment of of the present invention, in the treatment of Dengfeng City of Henan Province three health hospital outpatient for catching a cold; 2008--2011 to accept cold patients 234 example June for medical treatment, age 20-30 year 25 examples, 31-40 year 56 examples, 41-50 year 89 examples, more than 50 years old 64 is routine; The 2 doses of healing persons 97 that wherein take medicine are routine, 3 doses of healing persons 93 examples, 4 doses of healing persons 44 examples.

For Da Gengjia result of use, present invention also offers the preparation method of this Chinese medicine preparation; Its preparation method is following step: step one) weighting raw materials material Herba Violae 15 parts, Folium Isatidis 20 parts, Radix Isatidis 35 parts, Flos Lonicerae 15 parts, the Radix Astragali 15 parts, Fructus Forsythiae 20 parts, Radix Platycodonis 20 parts, Herba Taraxaci 35 parts, Rhizoma Polygoni Cuspidati 20 parts, Radix Scrophulariae 20 parts, 10 parts, Radix Glycyrrhizae, Herba Houttuyniae 20 parts, Herba Artemisiae Annuae 20 parts, remove impurity, eluriate rapidly with cold boiled water water, drain water liquid, dry;

Step 2), step one) the aseptic raw material that obtains adds warm water soaking 30 minutes, uses instead after little fire boils medicine 45 minutes, filtering liquid medicine after big fire is boiled;

Step 3), step 2) filter after medicinal residues add water, use instead after little fire boils medicine 90 minutes after big fire is boiled, filtering liquid medicine;

Step 4) by step 2, step 3) the institute's medicinal liquid that obtains merging, obtain commodity Chinese medicine preparation.

Decoction oral is main, and every day takes orally for 2 times sooner or later, each 120ml decoction being taken warmly.Decoction then acts on fast and power is high, is adapted to the more anxious severe one of the state of an illness.

Detailed description of the invention

Describedly be used for the treatment of grippal Chinese medicine preparation and preparation method, it is characterized in that, the raw material of Chinese medicine of selection and weight portion respectively: Herba Violae 15 parts, Folium Isatidis 20 parts, Radix Isatidis 35 parts, Flos Lonicerae 15 parts, the Radix Astragali 15 parts, Fructus Forsythiae 20 parts, Radix Platycodonis 20 parts, Herba Taraxaci 35 parts, Rhizoma Polygoni Cuspidati 20 parts, Radix Scrophulariae 20 parts, 10 parts, Radix Glycyrrhizae, Herba Houttuyniae 20 parts, Herba Artemisiae Annuae 20 parts;

For Da Gengjia result of use, present invention also offers the preparation method of this Chinese medicine preparation; Its preparation method is following step: step one) weighting raw materials material Herba Violae 15 parts, Folium Isatidis 20 parts, Radix Isatidis 35 parts, Flos Lonicerae 15 parts, the Radix Astragali 15 parts, Fructus Forsythiae 20 parts, Radix Platycodonis 20 parts, Herba Taraxaci 35 parts, Rhizoma Polygoni Cuspidati 20 parts, Radix Scrophulariae 20 parts, 10 parts, Radix Glycyrrhizae, Herba Houttuyniae 20 parts, Herba Artemisiae Annuae 20 parts, remove impurity, eluriate rapidly with cold boiled water water, drain water liquid, dry;

Step 2), step one) the aseptic raw material that obtains adds warm water soaking 30 minutes, uses instead after little fire boils medicine 45 minutes, filtering liquid medicine after big fire is boiled;

Step 3), step 2) filter after medicinal residues add water, use instead after little fire boils medicine 90 minutes after big fire is boiled, filtering liquid medicine;

Step 4) by step 2, step 3) the institute's medicinal liquid that obtains merging, obtain commodity Chinese medicine preparation.

Claims (2)

1. be used for the treatment of grippal Chinese medicine preparation and preparation method, it is characterized in that, the raw material of Chinese medicine of selection and weight portion respectively: Herba Violae 15 parts, Folium Isatidis 20 parts, Radix Isatidis 35 parts, Flos Lonicerae 15 parts, the Radix Astragali 15 parts, Fructus Forsythiae 20 parts, Radix Platycodonis 20 parts, Herba Taraxaci 35 parts, Rhizoma Polygoni Cuspidati 20 parts, Radix Scrophulariae 20 parts, 10 parts, Radix Glycyrrhizae, Herba Houttuyniae 20 parts, Herba Artemisiae Annuae 20 parts.

2. the grippal Chinese medicine preparation for the treatment of according to claim 1, it is characterized in that: preparation method, its preparation method is following steps: step one) weighting raw materials material Herba Violae 15 parts, Folium Isatidis 20 parts, Radix Isatidis 35 parts, Flos Lonicerae 15 parts, the Radix Astragali 15 parts, Fructus Forsythiae 20 parts, Radix Platycodonis 20 parts, Herba Taraxaci 35 parts, Rhizoma Polygoni Cuspidati 20 parts, Radix Scrophulariae 20 parts, 10 parts, Radix Glycyrrhizae, Herba Houttuyniae 20 parts, Herba Artemisiae Annuae 20 parts, remove impurity, eluriate rapidly with cold boiled water water, drain water liquid, dry;

Step 2), step one) the aseptic raw material that obtains adds warm water soaking 30 minutes, uses instead after little fire boils medicine 45 minutes, filtering liquid medicine after big fire is boiled;

Step 3), step 2) filter after medicinal residues add water, use instead after little fire boils medicine 90 minutes after big fire is boiled, filtering liquid medicine;

Step 4) by step 2, step 3) the institute's medicinal liquid that obtains merging, obtain commodity Chinese medicine preparation.