CN107913402A - A kind of combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis and preparation method - Google Patents
A kind of combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis and preparation method Download PDFInfo
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- CN107913402A CN107913402A CN201610965124.2A CN201610965124A CN107913402A CN 107913402 A CN107913402 A CN 107913402A CN 201610965124 A CN201610965124 A CN 201610965124A CN 107913402 A CN107913402 A CN 107913402A
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Abstract
The invention discloses a kind of combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis and preparation method, belongs to pharmaceutical technology field；The raw material of combination of Chinese tradiational and Western medicine effective ingredient of the present invention forms：Pepsin, Metoclopramide, rotundin, forrest cranesbill root, common bombax root, sweet osmanthus, peking cabbage leaf, kaempferia galanga, rub Bai Ye, bergamot, champion bauhinia seed, foxtail millet seed, kusamaki broad-leaved podocarpus seed and receptacle, buerger raspberry root, orange peel and greyblue spicebush root；Combination of Chinese tradiational and Western medicine medicine of the present invention has the effect of unique to treatment atrophic gastritis, and preparation process is simple, it is evident in efficacy, good absorption effect, it is convenient to take, securely and reliably, control difficulty in relapse after healing, cost is relatively low, can achieve the purpose that to treat both principal and secondary aspect of disease, while also has effects that yin-nourishing benefit stomach, warming middle-JIAO and strengthening the spleen, anti-inflammatory analgetic and vital energy regualting and blood circulation-promoting.
Description
Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis and system
Preparation Method.
Background technology
Atrophic gastritis is also referred to as atrophic gastritis, and with gastric epithelial and body of gland atrophy, number is reduced, and stomach lining becomes
Thin, mucous membrane basic unit thickens, or with gland metaplasia and intestinal gland metaplasia, or the chronic digestible system disease for thering is atypical hyperplasia to be characterized
Disease.Upper abdomen secret anguish, turgor, belch often are shown as, is lost the appetite, or is become thin, anaemia etc., no specificity, is a kind of to cause a disease more
Because of disposition disease and precancerous lesion.
The clinical manifestation of atrophic gastritis not only lacks specificity, but also not fully consistent with lesion degree.Often occur
Following clinical manifestation：Gastral cavilty portion turgor, gastral cavilty portion pain, heartburn and indigestion symptom, stool abnormity and weakness symptom, it is poor
Blood.The symptom of atrophic gastritis, sign are without specificity, it is impossible to as the foundation of diagnosis, make a definite diagnosis mainly by gastroscope and stomach lining work
Tissue pathology checking.Age is more above middle age, and course of disease length, often there is chronic superficial gastritis medical history；Symptom and sign：Long-term digestion
Bad, gastral cavilty portion turgor is uncomfortable, receive it is poor, weak, become thin, anaemia etc.；Gastrocopy：Stomach lining color is thin out, blood vessel under mucous membrane
Seeing through, duplicature is tiny or even disappears, when atrophic gastritis is with body of gland neck hyperplasia or intestinal metaplasia, mucous membrane
Rough surface is uneven, is in granular form or nodositas, and visible pseudopolyp is formed sometimes, and the feature of exposed vessel is often covered under mucous membrane
Lid, the increase of atrophy mucous membrane brittleness, easy bleeding, and can have rotten to the corn stove, atrophic gastritis can be at the same time with chronic superficial gastritis
Performance, such as congested erythema, attachment mucus, and reflective enhancing etc.；Pathologic finding：Intrinsic body of gland atrophy in stomach lining, metaplasia,
Hyperplasia, canceration.
It is many to treat the medicine of atrophic gastritis, has Chinese medicine also to have Western medicine, but Western medicine dependence is strong, takes stopgap measures and does not control
This, and Chinese medicine slowly effect, course for the treatment of length, it is impossible to fundamentally release the pain of patient.Therefore, research one kind treats atrophic gastritis
Combination of Chinese tradiational and Western medicine medicine become one of important topic of people's research.
The content of the invention
The present invention provides a kind of combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis and preparation method；In the present invention
Doctor trained in Western medicine combination medicine has the effect of unique to treatment atrophic gastritis, and preparation process is simple, evident in efficacy, absorbs effect
Fruit is good, convenient to take, securely and reliably, controls difficulty in relapse after healing, and cost is relatively low, can achieve the purpose that to treat both principal and secondary aspect of disease, at the same time also
There is yin-nourishing benefit stomach, warming middle-JIAO and strengthening the spleen, anti-inflammatory analgetic and vital energy regualting and blood circulation-promoting.
To achieve the above object, technical scheme is implemented as follows：
A kind of combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis, is made the raw material group of the combination of Chinese tradiational and Western medicine effective ingredient
Into and parts by weight be：
0.1~0.5 part of pepsin, 0.01~0.05 part of Metoclopramide, 0.02~0.06 part of rotundin, forrest cranesbill root 46~62
Part, 46~62 parts of common bombax root, 45~61 parts of sweet osmanthus, 44~60 parts of peking cabbage leaf, 44~60 parts of kaempferia galanga, rubs 43~59 parts of Bai Ye,
43~59 parts of bergamot, 43~59 parts of champion bauhinia seed, 42~58 parts of foxtail millet seed, 42~58 parts of kusamaki broad-leaved podocarpus seed and receptacle, buerger raspberry root 41~57
Part, 39~55 parts of 40~56 parts of orange peel and greyblue spicebush root.
Be made the combination of Chinese tradiational and Western medicine effective ingredient raw material composition and parts by weight be：
0.2~0.4 part of pepsin, 0.02~0.04 part of Metoclopramide, 0.03~0.05 part of rotundin, forrest cranesbill root 50~58
Part, 50~58 parts of common bombax root, 49~57 parts of sweet osmanthus, 48~56 parts of peking cabbage leaf, 48~56 parts of kaempferia galanga, rubs 47~55 parts of Bai Ye,
47~55 parts of bergamot, 47~55 parts of champion bauhinia seed, 46~54 parts of foxtail millet seed, 46~54 parts of kusamaki broad-leaved podocarpus seed and receptacle, buerger raspberry root 45~53
Part, 43~51 parts of 44~52 parts of orange peel and greyblue spicebush root.
Be made the combination of Chinese tradiational and Western medicine effective ingredient raw material composition and parts by weight be：
0.3 part of pepsin, 0.03 part of Metoclopramide, 0.04 part of rotundin, 54 parts of forrest cranesbill root, 54 parts of common bombax root, sweet osmanthus 53
Part, 52 parts of peking cabbage leaf, 52 parts of kaempferia galanga, rubs 51 parts of Bai Ye, 51 parts of bergamot, 51 parts of champion bauhinia seed, 50 parts of foxtail millet seed, podocarpus
47 parts of 50 parts of reality, 49 parts of buerger raspberry root, 48 parts of orange peel and greyblue spicebush root.
A kind of preparation method for the combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis, includes the extraction work of following western medicine composition
Skill step：
（1）Pepsin is put into medicinal cupping, is stirred evenly with mixer, is put into 70 DEG C of drying postcoolings of baking oven, extraction is ground,
200 targeted fine powders were obtained, it is spare；
（2）Metoclopramide and rotundin are put into container, add the ethanol of 1~2 times of amount, dilution, puts
In being ground in microwave dryer with 5~8 DEG C of temperature low temperature dryings, extraction, 180 targeted fine powders were obtained, it is spare；
（3）By above-mentioned steps（1）~（2）The fine powder of acquisition is put into mixing in container, spare.
A kind of preparation method for the combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis, includes the extraction work of following traditional Chinese medicine ingredients
Skill step：
（1）By forrest cranesbill root, sweet osmanthus, rub Bai Ye and greyblue spicebush root is cleaned, 60% alcohol solution dippings 1~2 for immersing 5 times of amounts are small
When, when heating extraction 3 is small, ethanol is recycled, filtration, obtains filtrate, spare；
（2）Common bombax root, kaempferia galanga, bergamot and buerger raspberry root are put into container, add the distilled water of 3~6 times of amounts, heating boils 1
~2 it is small when, extract, filtering, obtain filtrate, it is spare；
（3）Peking cabbage leaf and orange peel are cleaned, shreds, is put into container, twists juice, impurity is filtered, stays juice spare；
（4）Champion bauhinia seed, foxtail millet seed and kusamaki broad-leaved podocarpus seed and receptacle are put into container, add the distilled water of 5~8 times of amounts, heating boils 2~
3 it is small when, extract, filtering, obtains filtrate, and heating is concentrated into paste, is put into 70 DEG C of drying postcoolings of baking oven, and extraction is ground, obtained
160 targeted fine powders, it is spare；
（5）By above-mentioned steps（1）~（4）Filtrate, juice and the fine powder of acquisition are mixed, and after stirring and dissolving is uniform, heating is dense
Shorten thick paste into, it is spare.
A kind of preparation method for the combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis, by the Western medicine fine powder and traditional Chinese medicine thick paste
Mixed, after stirring and dissolving is uniform, tablet is made in extraction, up to the combination of Chinese tradiational and Western medicine medicine of the treatment atrophic gastritis
Thing.
The pharmacological property of Chinese and Western medicine used in the present invention is as follows：
Pepsin：For white or pale yellow powder, it is no it is mould lose smelly, have and draw moist, aqueous solution shows acid reaction.For because eating egg
White property food excessively caused indigestion, after being ill convalescence digestive function decline and atrophic gastritis, stomach cancer, pernicious poor
Anapepsia caused by blood.
Metoclopramide：Odorless for white crystalline powder, bitter, dissolves in chloroform, in ethanol or propyl alcohol slightly
Molten, the soluble,very slightly in ether is almost insoluble in water, dissolves in an acidic solution.For gaseous distention indigestion, appetite
Depressed, belch, Nausea and vomiting also have a better effect；It is light to diabetic keratopathy stomach
Paralysis, gastroptosis etc. have certain curative effect；It is also used for pyloric stenosis and the duodenal ulcer invalid to conventional therapy.
Rotundin：For white or yellowish crystallization；It is odorless, it is tasteless；Light is met to be heated easy flavescence.The product are molten in chloroform
Solution, it is slightly molten in ethanol or ether, it is insoluble in water；It is readily soluble in dilute sulfuric acid.For the patient having a sleepless night by pain, also it is used for
Uterine contraction pain, tonicity insomnia, spasmodic cough etc. after the pain of gastric ulcer and duodenal ulcer, cramp, childbirth.
Forrest cranesbill root：Bitter, puckery, cold nature；Return liver, spleen, stomach, bladder warp.Clearing heat and promoting diuresis, cooling blood and hemostasis.Main diarrhea, dysentery
Disease, indigestion, gastral cavity abdomen, nosebleed epistaxis, has blood in stool, and has through excessive, and postpartum haemorrhage is more than, traumatic injury.
Common bombax root：Mildly bitter flavor, it is cool in nature；Returns spleen, stomach.Dispelling wind and eliminating dampness, clearing heat and detoxicating, eliminating stagnation to stop pain.Main arthralgia pain due to rheumatism, stomach
Bitterly, dysentery characterized by blood in the stool, postpartum edema, scrofula, bruises and sprains.
Sweet osmanthus：Acrid flavour, it is warm-natured.Resolving sputum, dissipates the stasis of blood.Control phlegm and retained fluid and ridicule cough, intestines wind bloody flux, hernia lump in the abdomen, toothache, halitosis.《Book on Chinese herbal medicine converges
Speech》Carry：" cold scattering gas, dispersing blood stasis blood, stops intestines wind bloody flux.All to suffer from cold sensation of the genitalia cold air, lump in the abdomen hernia run quickly globefish, all interior cold diseases of abdomen, steaming cloth, which is wrapped up in, to be pressed
It.”
Peking cabbage leaf：It is sweet in flavor, it is mild-natured；Return stomach, bladder warp.Tonneau stomach, nourishing the stomach is with, diuresis.Main oedema, gastritis.
Kaempferia galanga：Acrid flavour, it is warm-natured；Return stomach, the spleen channel.Middle benefit gas dehumidifies, promoting the circulation of qi helps digestion, analgesic.Main coldness and pain in the epigastrium, cold-dampness are vomited and diarrhoea,
Cholera, fullness and oppression of chest and abdomen, diet do not disappear, toothache, arthralgia pain due to rheumatism.
Rub Bai Ye：Bitter, it is cool in nature.It is clearing heat and detoxicating.For dysentery, acute gastroenteritis, stomatitis, urinary tract infections；External application is controlled
Burn and scald, sore swollen toxin, pruitus.
Bergamot：Acrid flavour, hardship, it is warm-natured；Return liver, stomach, spleen, lung channel.Liver-smoothing, qi-regulating, and stomach resolving sputum.The side of body of main stagnation of liver qi
Bitterly, it is uncomfortable in chest, liver-stomach disharmony, the abdominal distention of the taste stagnation of the circulation of vital energy, heating, nausea, chronic cough abundant expectoration.
Champion bauhinia seed：It is bitter, pungent, it is warm-natured；Return liver, stomach.Promoting qi circulation and relieving pain, it is promoting blood circulation and removing blood stasis.The main distending pain in hypochondrium, epigastric pain,
Traumatic injury.《The south of the Five Ridges is gathered medicinal herbs record》Carry：" only gas pain, reason bruise wound, stasis eliminatings life are new.”
Foxtail millet seed：It is sweet in flavor, cold nature；Returns spleen, stomach.QI invigorating, and middle relieving restlessness are quenched the thirst.The empty vomiting of main stomach, polydipsia.
Kusamaki broad-leaved podocarpus seed and receptacle：It is sweet in flavor, slightly warm in nature.Promoting qi circulation and relieving pain, middle benefit gas are enriched blood.Main gastral cavity pain, deficiency of blood sallow complexion.《Physics
Small knowledge》Carry：" kidney tonifying, beneficial lung.”
Buerger raspberry root：Bitter, acid, it is cold in nature；Return liver and kidney channel.It is clearing heat and detoxicating, promoting blood circulation and stopping pain.Main jaundice with damp-heat pathogen, postpartum fever, children
High fever, irregular menstruation, leukorrhea, folic acid of having a stomachache, hemorrhoid gall, anus fistulae.
Orange peel：Acrid flavour, hardship, it is warm-natured；Returns spleen, lung channel.Promoting the circulation of qi invigorating the spleen, lowering the adverse-rising QI and eliminating phlegm.The abdominal fullness and distention of the main taste stagnation of the circulation of vital energy, is disliked
The heart is vomitted, and loss of appetite, the coughing with a lot of sputum of phlegm stops up the circulation of vital energy in the wrong direction, septum pectorale expires vexed, globus hysteriocus.
Greyblue spicebush root：Acrid flavour, hardship, it is warm-natured；Return liver, stomach.Dispelling wind and removing obstruction in the meridians, vital energy regualting and blood circulation-promoting is inducing diuresis and reducing edema, preventing phlegm from forming and stopping coughing.
Main arthralgia pain due to rheumatism, traumatic injury, gastral cavity pain, de-power internal lesion caused by overexertion, bronchitis, oedema.
Compared with prior art, the present invention have the advantages that：
Combination of Chinese tradiational and Western medicine medicine of the present invention has the effect of unique to treatment atrophic gastritis, and preparation process is simple, and curative effect is shown
Write, good absorption effect is convenient to take, securely and reliably, controls difficulty in relapse after healing, and cost is relatively low, can reach the mesh treated both principal and secondary aspect of disease
, while also there is yin-nourishing benefit stomach, warming middle-JIAO and strengthening the spleen, anti-inflammatory analgetic and vital energy regualting and blood circulation-promoting.
Embodiment
The present invention is further elaborated with reference to specific embodiment.
Embodiment 1
The raw material of combination of Chinese tradiational and Western medicine effective ingredient of the present invention forms and weight is：
Pepsin 0.4g, Metoclopramide 0.04g, rotundin 0.05g, forrest cranesbill root 58g, common bombax root 58g, sweet osmanthus 57g, yellow bud
Chinese cabbage 56g, kaempferia galanga 56g, rub Bai Ye 55g, bergamot 55g, champion bauhinia seed 55g, foxtail millet seed 54g, kusamaki broad-leaved podocarpus seed and receptacle 54g, buerger raspberry root
53g, orange peel 52g and greyblue spicebush root 51g.
A kind of preparation method for the combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis, includes the extraction work of following western medicine composition
Skill step：
（1）Pepsin is put into medicinal cupping, is stirred evenly with mixer, is put into 70 DEG C of drying postcoolings of baking oven, extraction is ground,
200 targeted fine powders were obtained, it is spare；
（2）Metoclopramide and rotundin are put into container, add the ethanol of 1~2 times of amount, dilution, is placed in microwave dryer
It is interior to be ground with 5~8 DEG C of temperature low temperature dryings, extraction, 180 targeted fine powders were obtained, it is spare；
（3）By above-mentioned steps（1）~（2）The fine powder of acquisition is put into mixing in container, spare.
A kind of preparation method for the combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis, includes the extraction work of following traditional Chinese medicine ingredients
Skill step：
（1）By forrest cranesbill root, sweet osmanthus, rub Bai Ye and greyblue spicebush root is cleaned, 60% alcohol solution dippings 1~2 for immersing 5 times of amounts are small
When, when heating extraction 3 is small, ethanol is recycled, filtration, obtains filtrate, spare；
（2）Common bombax root, kaempferia galanga, bergamot and buerger raspberry root are put into container, add the distilled water of 3~6 times of amounts, heating boils 1
~2 it is small when, extract, filtering, obtain filtrate, it is spare；
（3）Peking cabbage leaf and orange peel are cleaned, shreds, is put into container, twists juice, impurity is filtered, stays juice spare；
（4）Champion bauhinia seed, foxtail millet seed and kusamaki broad-leaved podocarpus seed and receptacle are put into container, add the distilled water of 5~8 times of amounts, heating boils 2~
3 it is small when, extract, filtering, obtains filtrate, and heating is concentrated into paste, is put into 70 DEG C of drying postcoolings of baking oven, and extraction is ground, obtained
160 targeted fine powders, it is spare；
（5）By above-mentioned steps（1）~（4）Filtrate, juice and the fine powder of acquisition are mixed, and after stirring and dissolving is uniform, heating is dense
Shorten thick paste into, it is spare.
A kind of preparation method for the combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis, by the Western medicine fine powder and traditional Chinese medicine thick paste
Mixed, after stirring and dissolving is uniform, tablet is made in extraction, up to the combination of Chinese tradiational and Western medicine medicine of the treatment atrophic gastritis
Thing.
Usage and dosage：Oral, 2 times a day, each 1 time sooner or later, 1 tablet once（Every 0.5g）, warm water delivery service；6 days are 1
The course for the treatment of, 2~4 courses for the treatment of can fully recover, and serious patient increases the amount of discretion.
Embodiment 2
The raw material of combination of Chinese tradiational and Western medicine effective ingredient of the present invention forms and weight is：
Pepsin 0.3g, Metoclopramide 0.03g, rotundin 0.04g, forrest cranesbill root 54g, common bombax root 54g, sweet osmanthus 53g, yellow bud
Chinese cabbage 52g, kaempferia galanga 52g, rub Bai Ye 51g, bergamot 51g, champion bauhinia seed 51g, foxtail millet seed 50g, kusamaki broad-leaved podocarpus seed and receptacle 50g, buerger raspberry root
49g, orange peel 48g and greyblue spicebush root 47g.
The combination of Chinese tradiational and Western medicine process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.
Embodiment 3
The raw material of combination of Chinese tradiational and Western medicine effective ingredient of the present invention forms and weight is：
Pepsin 0.2g, Metoclopramide 0.02g, rotundin 0.03g, forrest cranesbill root 50g, common bombax root 50g, sweet osmanthus 49g, yellow bud
Chinese cabbage 48g, kaempferia galanga 48g, rub Bai Ye 47g, bergamot 47g, champion bauhinia seed 47g, foxtail millet seed 46g, kusamaki broad-leaved podocarpus seed and receptacle 46g, buerger raspberry root
45g, orange peel 44g and greyblue spicebush root 43g.
The combination of Chinese tradiational and Western medicine process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.
Embodiment 4
The raw material of combination of Chinese tradiational and Western medicine effective ingredient of the present invention forms and weight is：
Pepsin 0.1g, Metoclopramide 0.01g, rotundin 0.02g, forrest cranesbill root 46g, common bombax root 46g, sweet osmanthus 45g, yellow bud
Chinese cabbage 44g, kaempferia galanga 44g, rub Bai Ye 43g, bergamot 43g, champion bauhinia seed 43g, foxtail millet seed 42g, kusamaki broad-leaved podocarpus seed and receptacle 42g, buerger raspberry root
41g, orange peel 40g and greyblue spicebush root 39g.
The combination of Chinese tradiational and Western medicine process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.
Toxicity test：
1st, acute toxicity test：
（1）Mouse 40 is chosen, half male and half female, 20~35g of weight, carries out acute toxicity test.Mouse is randomly divided into two groups, i.e.,
Experimental group and control group, when fasting 12 is small before experiment；
（2）1 is taken to be dissolved in 10ml water the combination of Chinese tradiational and Western medicine medicine of the present invention, it is spare；
（3）Take and step（2）Normal saline, it is spare；
（4）Take step（2）In combination of Chinese tradiational and Western medicine drug solution of the present invention by gavage volume be 5ml/kg perfusion amount to experiment
20 mouse of group carry out perfusion；It is administered 2 times within one day, when delivery time 6 is small, continuous observation 14 days after administration, and record
The toxic reaction and death toll of mouse；
（5）Take step（3）In normal saline by the perfusion amount that gavage volume is 5ml/kg to 20 mouse of control group
Carry out perfusion；It is administered 2 times within one day, when delivery time 6 is small, continuous observation 14 days after administration, and the toxicity for recording mouse is anti-
Should and death toll；
Test result indicates that：Compared with the control group, mouse has no notable difference after experimental group administration, tests continuous observation 14 days,
Mouse systemic situation, diet, drinking-water, body weight increase are normal.
2nd, long term toxicity test：
Mouse 40 is chosen, half male and half female, 20~35g of weight, carries out long term toxicity test.By the combination of Chinese tradiational and Western medicine medicine of the present invention
Thing takes 1 to be dissolved in 10ml water, and perfusion is carried out to mouse by the perfusion amount that gavage volume is 5ml/kg, 2 times a day, continuous to use
Medicine is discontinued 3 weeks after 15 weeks, carries out Germicidal efficacy.
Test result indicates that：Combination of Chinese tradiational and Western medicine medicine of the present invention is to the hair of mouse, behavior, stool and urine, weight, internal organs weight
The indexs such as amount, blood picture, hepatic and renal function, blood glucose, blood fat have no significant effect, and internal organs naked eyes are without the abnormal change of discovery, histology
Inspection result shows that also nothing is substantially change Organs of Mice；Illustrate combination of Chinese tradiational and Western medicine medicine of the present invention to mouse long-term administration
Small toxicity afterwards, does not have abnormal reaction, using safety yet after drug withdrawal.
Clinical data：
First, case selection：
As the combination of Chinese tradiational and Western medicine medicine for the treatment of atrophic gastritis, 177 clinical observations of patients with atrophic gastritis made a definite diagnosis are selected,
Patient is randomly divided into tri- groups for the treatment of group, control group A and control group B, wherein treatment group 59, male 29, women 30, age
20~59 years old, average age 39.5 years old, average course of disease 1 year；Control group A 59, wherein male 30, women 29, age 21
~58 years old, average age 39.5 years old, average course of disease 1 year；Control group B59, wherein male 29, women 30, the age 20~
59 years old, average age 39.5 years old, average course of disease 1 year.
Treatment group, the course of disease, the degrees of symptoms of tri- groups of cases of control group A and control group B are basically identical, no significance difference
It is different, it is comparable.
2nd, medicament selection：
Treatment group uses combination of Chinese tradiational and Western medicine medicine of the present invention, takes orally, and 2 times a day, each 1 time sooner or later, 1 tablet once（Every 0.5g）,
Warm water delivery service；6 days are 1 course for the treatment of, and 2~4 courses for the treatment of can fully recover, and serious patient increases the amount of discretion.
Control group A takes WEIFUCHUN PIAN, take orally, one time 4,3 times a day.
Control group B takes stomach warming and soothing capsules, take orally, one time 3,2 times a day.
3rd, curative effect judges：
Cure：Clinical symptoms and sign all disappear, and stomach functional rehabilitation is normal.It is effective：Clinical symptoms and sign
It is clearly better, stomach function is substantially recovered.Effectively：Clinical symptoms and sign have improved, and stomach function has been recovered.It is invalid：
Without improvement or aggravated by above-mentioned symptom after treatment.
4th, treatment results：
The above results show that the cure rate and total effective rate for the treatment of group are apparently higher than control group A and control group B.
5th, model case：
1st, Cui, female, 29 years old.Patient diet is irregular, once in a while stomach distending pain, and a small amount of feed can also feel glutted, and appetite is not
Shake, go to hospital to do gastrocopy, be diagnosed as atrophic gastritis, used a variety of drug therapies, therapeutic effect is bad, later our hospital
Treatment, through taking combination of Chinese tradiational and Western medicine drug therapy of the present invention, after taking 1 course for the treatment of, malaise symptoms substantially mitigate, appetite increase,
Continue after taking 2 courses for the treatment of, malaise symptoms all disappear, and recovery from illness, follow-up is without recurrence after half a year.
2nd, health, man, 34 years old.Patient suffers from atrophic gastritis more than 1 year, and the vexed swollen cusalgia aggravation in gastral cavilty portion, is off one's feed, palpitaition
Agitation, dizzy, dry, goes to hospital to do gastrocopy, is diagnosed as atrophic gastritis, doctor gives combination of Chinese tradiational and Western medicine medicine of the present invention
Treatment, after taking 1 course for the treatment of, symptom has improved, and after taking 2 courses for the treatment of, symptom is clearly better, and continues after taking 2 courses for the treatment of,
Symptom all disappears, physical recovery health, recovery from illness, and follow-up is not recurred so far.
3rd, often certain, female, 41 years old.The frequent gastral cavilty calcination of patient, goes to hospital to do gastrocopy, is diagnosed as atrophic gastritis, make
Used drug therapy, therapeutic effect is general, and later our hospital's treatment, through taking combination of Chinese tradiational and Western medicine drug therapy of the present invention, takes 1
After the course for the treatment of, symptom substantially mitigates, and after taking 3 courses for the treatment of, symptom all disappears, and recovery from illness, follow-up is without recurrence after half a year.
4th, river, man, 50 years old.The indistinct distending pain of patient's upper abdomen, has sour regurgitation and Ai Qi ﹑ weak, goes to hospital to do gastrocopy, examine
Break and give combination of Chinese tradiational and Western medicine drug therapy of the present invention for atrophic gastritis, doctor, after taking 1 course for the treatment of, symptom is clearly better, meal
Amount increase, continues after taking 2 courses for the treatment of, and appetite is recovered, and all diseases disappear
Lose, recovery from illness, follow-up is without recurrence after 1 year.
5th, it is military certain, female, 49 years old.Patient is often dizzy, weak, and gastral cavilty calcination, goes to hospital to do gastrocopy, be diagnosed as atrophy
Property gastritis, doctor gives combination of Chinese tradiational and Western medicine drug therapy of the present invention, and after taking 1 course for the treatment of, malaise symptoms have been alleviated, and takes 2
After a course for the treatment of, malaise symptoms are relieved, and are continued after taking 1 course for the treatment of, and symptom disappears, and recovery from illness, follow-up is without recurrence after half a year.
6th, Mr. Li, man, 57 years old.Patient's upper abdomen distending pain, goes to hospital to do gastrocopy, is diagnosed as atrophic gastritis, doctor
Combination of Chinese tradiational and Western medicine drug therapy of the present invention is given, after taking 1 course for the treatment of, symptom has mitigated, and after taking 2 courses for the treatment of, symptom is bright
It is aobvious to mitigate, continue after taking 1 course for the treatment of, symptom all disappears, and recovery from illness, follow-up is not recurred so far.
Finally it should be noted that：The above described is only a preferred embodiment of the present invention, it is not that it is made to the present invention
The limitation of its form, every without departing from technical solution of the present invention content, that is done in the application range according to the present invention any repaiies
Change, equivalent substitution and improvement etc., still fall within the protection domain of technical solution of the present invention.
Claims (6)
- A kind of 1. combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis, it is characterised in that：The combination of Chinese tradiational and Western medicine medicine, which is made, to be had The raw material of effect component forms and parts by weight are：0.1~0.5 part of pepsin, 0.01~0.05 part of Metoclopramide, 0.02~0.06 part of rotundin, forrest cranesbill root 46~62 Part, 46~62 parts of common bombax root, 45~61 parts of sweet osmanthus, 44~60 parts of peking cabbage leaf, 44~60 parts of kaempferia galanga, rubs 43~59 parts of Bai Ye, 43~59 parts of bergamot, 43~59 parts of champion bauhinia seed, 42~58 parts of foxtail millet seed, 42~58 parts of kusamaki broad-leaved podocarpus seed and receptacle, buerger raspberry root 41~57 Part, 39~55 parts of 40~56 parts of orange peel and greyblue spicebush root.
- A kind of 2. combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis according to claim 1, it is characterised in that：Institute is made State combination of Chinese tradiational and Western medicine effective ingredient raw material composition and parts by weight be：0.2~0.4 part of pepsin, 0.02~0.04 part of Metoclopramide, 0.03~0.05 part of rotundin, forrest cranesbill root 50~58 Part, 50~58 parts of common bombax root, 49~57 parts of sweet osmanthus, 48~56 parts of peking cabbage leaf, 48~56 parts of kaempferia galanga, rubs 47~55 parts of Bai Ye, 47~55 parts of bergamot, 47~55 parts of champion bauhinia seed, 46~54 parts of foxtail millet seed, 46~54 parts of kusamaki broad-leaved podocarpus seed and receptacle, buerger raspberry root 45~53 Part, 43~51 parts of 44~52 parts of orange peel and greyblue spicebush root.
- A kind of 3. combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis according to claim 1, it is characterised in that：Institute is made State combination of Chinese tradiational and Western medicine effective ingredient raw material composition and parts by weight be：0.3 part of pepsin, 0.03 part of Metoclopramide, 0.04 part of rotundin, 54 parts of forrest cranesbill root, 54 parts of common bombax root, sweet osmanthus 53 Part, 52 parts of peking cabbage leaf, 52 parts of kaempferia galanga, rubs 51 parts of Bai Ye, 51 parts of bergamot, 51 parts of champion bauhinia seed, 50 parts of foxtail millet seed, podocarpus 47 parts of 50 parts of reality, 49 parts of buerger raspberry root, 48 parts of orange peel and greyblue spicebush root.
- 4. a kind of preparation method for the combination of Chinese tradiational and Western medicine medicine that atrophic gastritis is treated as described in any one of claims 1 to 3, its It is characterized in that：Extraction process step including following western medicine composition：（1）Pepsin is put into medicinal cupping, is stirred evenly with mixer, is put into 70 DEG C of drying postcoolings of baking oven, extraction is ground, 200 targeted fine powders were obtained, it is spare；（2）Metoclopramide and rotundin are put into container, add the ethanol of 1~2 times of amount, dilution, is placed in microwave dryer It is interior to be ground with 5~8 DEG C of temperature low temperature dryings, extraction, 180 targeted fine powders were obtained, it is spare；（3）By above-mentioned steps（1）~（2）The fine powder of acquisition is put into mixing in container, spare.
- 5. a kind of preparation method for the combination of Chinese tradiational and Western medicine medicine that atrophic gastritis is treated as described in any one of Claims 1 to 4, its It is characterized in that：Extraction process step including following traditional Chinese medicine ingredients：（1）By forrest cranesbill root, sweet osmanthus, rub Bai Ye and greyblue spicebush root is cleaned, 60% alcohol solution dippings 1~2 for immersing 5 times of amounts are small When, when heating extraction 3 is small, ethanol is recycled, filtration, obtains filtrate, spare；（2）Common bombax root, kaempferia galanga, bergamot and buerger raspberry root are put into container, add the distilled water of 3~6 times of amounts, heating boils 1 ~2 it is small when, extract, filtering, obtain filtrate, it is spare；（3）Peking cabbage leaf and orange peel are cleaned, shreds, is put into container, twists juice, impurity is filtered, stays juice spare；（4）Champion bauhinia seed, foxtail millet seed and kusamaki broad-leaved podocarpus seed and receptacle are put into container, add the distilled water of 5~8 times of amounts, heating boils 2~ 3 it is small when, extract, filtering, obtains filtrate, and heating is concentrated into paste, is put into 70 DEG C of drying postcoolings of baking oven, and extraction is ground, obtained 160 targeted fine powders, it is spare；（5）By above-mentioned steps（1）~（4）Filtrate, juice and the fine powder of acquisition are mixed, and after stirring and dissolving is uniform, heating is dense Shorten thick paste into, it is spare.
- 6. the preparation method of the combination of Chinese tradiational and Western medicine medicine of atrophic gastritis is treated according to claim 4 or claim 5, its It is characterized in that：The Western medicine fine powder and traditional Chinese medicine thick paste are mixed, after stirring and dissolving is uniform, tablet is made in extraction, up to institute The combination of Chinese tradiational and Western medicine medicine for the treatment atrophic gastritis stated.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602759A (en) * | 2019-01-17 | 2019-04-12 | 广西医科大学 | The purposes of kusamaki broad-leaved podocarpus seed and receptacle polysaccharide |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602759A (en) * | 2019-01-17 | 2019-04-12 | 广西医科大学 | The purposes of kusamaki broad-leaved podocarpus seed and receptacle polysaccharide |
| CN109602759B (en) * | 2019-01-17 | 2020-10-09 | 广西医科大学 | Application of podocarpus macrophyllus polysaccharide |
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