CN106421600A - Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and preparation method - Google Patents

Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and preparation method Download PDF

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CN106421600A
CN106421600A CN201610924060.1A CN201610924060A CN106421600A CN 106421600 A CN106421600 A CN 106421600A CN 201610924060 A CN201610924060 A CN 201610924060A CN 106421600 A CN106421600 A CN 106421600A
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赵爱艳
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Abstract

The invention discloses a Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and a preparation method, which belong to the technical field of medicines. The Chinese-Western medicine compound preparation is prepared from the following effective constituents: cimetidine, rebamipide, irsogladine, callicarpa macrophylla, carex baccans seed, common tetragonia herb, clustered knotweed herb, nephelium lappaceum, broadbean pericarp, chachi citrus leaf, climbing violet herb, hylomecon japonica, cardamom, elsholtzia blanda benth, buckwheat and Yunnan pleione tuber. The Chinese-Western medicine compound preparation provided by the invention is prepared from combining traditional Chinese medicine and Western medicine, has the efficacy on clearing heat and stop bleeding, removing food retention and resolving dampness, invigorating stomach and promoting digestion, can directly arrive a diseased region through compatibility of various medicines, has a unique curative effect on treating various symptoms such as dizziness, flusteredness, cold sweat, weakness and thirsty caused by alimentary tract hemorrhage, and is obvious in curative effect, faster in effect, convenient to take, safe and reliable, lower in cost, and not easy to recur after cure.

Description

A kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract and preparation method
Art
The present invention relates to pharmaceutical technology field, more particularly, to a kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract and system Preparation Method.
Background technology
Hemorrhage of digestive tract is clinical common syndrome, can be caused by multiple diseases, and alimentary canal refers to from oesophagus to anus Pipeline, including oesophagus, Stomach duodenum, jejunum, ileum, caecum, colon and rectum.UGB refers to duodenum Oesophagus more than suspensorium, the bleeding of Stomach duodenum, epimere jejunum and ductus pancreaticus and bile duct, below ligament of Treitz Intestinal bleeding be referred to as hemorrhage of lower digestive tract.
Hemorrhage of digestive tract can cause because of factors such as the inflammation of alimentary canal itself, mechanical injuries, vascular lesion, tumours, Caused by alimentary canal being involved because of the pathology of adjacent organs and systemic disease.In, hemorrhage of lower digestive tract：Anal tube disease hemorrhoid, anal fissure, Anal fistula；Recial disease proctitis ulcerosa, tumour, class cancer, neighbouring malignant tumour or abscess invade rectum, infection, ischemic etc.；Knot Intestinal disease infection, ulcerative colitis, diverticulum, tumour, ischemic and vascular malformation, entembole etc.；Disease of intestine acute hemorrhagic Necrotic enteritis, intestinal tuberculosis, Crohn disease, diverticulitis or ulcer, entembole, tumour, hemangioma, vascular malformation, ischemic etc..
Different according to bleeding part and amount of bleeding, bleeding rate, clinical manifestation is different.General status are in a small amount（400ml with Under）, no obvious subjective symptoms more than chronic bleeding.Acute, dizzy, the nervous, disease such as cold sweat, weak, dry occurs when bleeding profusely Shape, even faint, the symptom such as four limbs are ice-cold, oliguria, dysphoria, shock.Vital sign：Pulse and blood pressure change are journeys of losing blood The important indicator of degree.During acute gastrointestinal bleeding, blood volume falls sharply, and initial body compensation is increased heart rate, if can not , shock state then acrotism, or even lay one's hand on unclear in hemostasis or replenishment of blood content in time.Shock early stage blood pressure can be with compensatory Raise, increase with amount of bleeding, blood pressure is gradually reduced, enter hemorrhagic shock.Other simultaneous phenomenons and sign：According to former Send out the difference of disease, can with other corresponding clinical manifestations, such as stomachache, heating, intestinal obstruction, spitting blood, have blood in stool, tarry stool, Abdominal mass, spider angioma, subcutaneous varicos vein of abdominal wall, jaundice etc..
At present treatment hemorrhage of digestive tract nothing more than Chinese medicine and two kinds of Western medicine, western medicine quick result, but drug-dependent By force, cure the symptoms, not the disease, and expensive, and treatment by Chinese herbs take effect relatively slow, the course for the treatment of longer it is impossible to fundamentally release the pain of patient Bitter.
Content of the invention
The invention provides a kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract and preparation method；Chinese and Western medicine of the present invention Compound preparation is combined by Chinese medicine and Western medicine and is formulated, and has functions that clearing away heat to stop bleeding, disappear long-pending dampness elimination, stomach strengthening and digestion promoting, All medicine phases are closed and can directly be reached diseased region, dizzy, nervous, cold sweat, the weak, dry etc. causing for treatment hemorrhage of digestive tract Various symptoms have the curative effect of uniqueness, and determined curative effect, quick result, taking convenience, and safe and reliable, cost is relatively low, after healing It is difficult to recur.
For achieving the above object, technical scheme enforcement is as follows：
A kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, makes the raw material group of described Chinese and Western medicine compound preparation active ingredient Become and parts by weight are：
0.1～0.3 part of Cimetidine, 0.06～0.1 part of Rebamipide, 0.01～0.05 part of Irsogladine, bigleafbeautyberry root or leaf 9～25 Part, 9～25 parts of baccate sedge herb, 8～24 parts of New Zealand spinach, 8～24 parts of clustered knotweed herb, 7～23 parts of nephelium lappaceum, 6～22 parts of broadbean pericarp, mandarin orange leaf 6 ～22 parts, 5～21 parts of climbing violet herb, 7 5～21 parts of honey raisin tree, 4～20 parts of White Chloe, chicken gizzard dissipates 4～20 parts, 3～19 parts of buckwheat and solely 2～18 parts of the leaf bletilla striata.
Make the raw material composition of described Chinese and Western medicine compound preparation active ingredient and parts by weight are：
0.15～0.25 part of Cimetidine, 0.07～0.09 part of Rebamipide, 0.02～0.04 part of Irsogladine, bigleafbeautyberry root or leaf 13 ～21 parts, 13～21 parts of baccate sedge herb, 12～20 parts of New Zealand spinach, 12～20 parts of clustered knotweed herb, 11～19 parts of nephelium lappaceum, broadbean pericarp 10～18 Part, 10～18 parts of mandarin orange leaf, 9～17 parts of climbing violet herb, 7 9～17 parts of honey raisin tree, 8～16 parts of White Chloe, chicken gizzard dissipates 8～16 parts, buckwheat 7～ 15 parts and 6～14 parts of yunnan pleione tuber.
Make the raw material composition of described Chinese and Western medicine compound preparation active ingredient and parts by weight are：
0.2 part of Cimetidine, 0.08 part of Rebamipide, 0.03 part of Irsogladine, 17 parts of bigleafbeautyberry root or leaf, 17 parts of baccate sedge herb, New Zealand spinach 16 parts, 16 parts of clustered knotweed herb, 15 parts of nephelium lappaceum, 14 parts of broadbean pericarp, 14 parts of mandarin orange leaf, 13 parts of climbing violet herb, 7 13 parts of honey raisin tree, White Chloe 12 Part, scattered 12 parts of chicken gizzard, 11 parts of buckwheat and 10 parts of yunnan pleione tuber.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, including the extraction work of following western medicine composition Skill step：
（1）Cimetidine is put in container, adds the ethanol of 1～2 times amount, dilution, be placed in microwave dryer with 5～8 DEG C Temperature low temperature drying, extraction is ground into powder, obtains the fine powder of 180 mesh, standby；
（2）Rebamipide and Irsogladine are put in medicinal cupping, is stirred with mixer, put into cold after 70 DEG C of baking oven is dried But, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
（3）By above-mentioned steps（1）~（2）The fine powder obtaining puts into mixing in container, and extraction is ground into powder, obtains the fine powder of 200 mesh, Standby.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, including the extraction work of following traditional Chinese medicine ingredients Skill step：
（1）Bigleafbeautyberry root or leaf, baccate sedge herb, New Zealand spinach and White Chloe are put in container, adds the distilled water of 5～8 times amount, heating boils 2 ～3 hours, extract, filter, obtain filtrate, heating is concentrated into pasty state, put into after 70 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains Cross the fine powder of 160 mesh, standby；
（2）Clustered knotweed herb, nephelium lappaceum, broadbean pericarp and buckwheat are put in container, adds the distilled water of 3～6 times amount, heating boils 1 ～2 hours, extract, filter, obtain filtrate, standby；
（3）Mandarin orange leaf, climbing violet herb and chicken gizzard are dissipated and cleans, chopping, put in container, twist juice, filter impurity, stay juice standby；
（4）Honey raisin tree seven is cleaned, immersion 3 times amount 60% alcohol solution dipping 1～2 hour, heating extraction 3 hours, reclaims second Alcohol, filtration, obtain filtrate, standby；
（5）Yunnan pleione tuber is put in container, carries out pulverization process, grind into powder, obtained the fine powder of 180 mesh, standby；
（6）By above-mentioned steps（1）~（5）The fine powder that obtains, filtrate and carry out juice mixing, after stirring and dissolving is uniform, heating is dense It is reduced to pasty state, put into after 60 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains the fine powder of 200 mesh, standby.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, by described Western medicine fine powder and traditional Chinese medicine fine powder Mixed, after stirring and dissolving is uniform, extracts and make tablet, obtained final product the Chinese and Western medicine compound system of described treatment hemorrhage of digestive tract Agent.
The property of medicine of Chinese and Western medicine used by the present invention is as follows：
Cimetidine：For white or off-white color crystalline powder；Almost odorless, bitter.Readily soluble in methyl alcohol, molten in ethanol Solution, slightly molten in isopropanol, slightly soluble in water, readily soluble in watery hydrochloric acid.For treat duodenal ulcer, gastric ulcer, on disappear Change gastrointestinal hemorrhage, chronic colitis, herpes zoster, the disease such as chronic urticaria.Antiviral and Immune-enhancing effect are had certain effect.
Rebamipide：It is mainly used in the Acute Exacerbation Period gastric mucosal lesion of gastric ulcer, acute gastritis and chronic gastritis（Rotten Rotten, bleeding, hyperemia, oedema）Improvement.
Irsogladine：For gastric ulcer, it is also used for improving the gastric mucosa disease of acute gastritis and chronic gastritis acute attack stage Become（Erosion, bleeding, hyperemia, oedema etc.）.
Bigleafbeautyberry root or leaf：Taste is pungent, hardship, mild-natured；The thoughts of returning home, lung channel.Dissipate stasis of blood hemostasis, swelling and pain relieving.Main spitting of blood, bleeding from five sense organs or subcutaneous tissue, spit blood, just Blood, traumatic bleeding, bruise is swollen, arthralgia due to wind-dampness.Guangzhou army《Conventional Chinese herbal medicine handbook》Carry：" hemostasis, pain relieving, eliminating stasis to subdue swelling. Control hemorrhage of digestive tract, spitting of blood, bleeding from five sense organs or subcutaneous tissue, traumatic bleeding, bleeding of having tooth pulled out, treating swelling and pain by traumatic injury, treating rheumatic ostealgia.”
Baccate sedge herb：Sweet, micro-pungent, mild-natured；Return liver warp.Promoting eruption cough-relieving, bowl spares Li Shui.Djumah rash, varicella, pertussis, prolapse of the anus, float Swollen.
New Zealand spinach：Sweet, micro-pungent, mild-natured；Return lung, liver, large intestine channel.Wind and heat dispersing, removing toxicity for detumescence.The hot hot eyes of main air, treats sore Swell and ache, enteritis, septicemia, tumour.
Clustered knotweed herb：Taste is pungent, mild-natured.Heat-clearing and damp-drying drug, invigorating the spleen disappears infantile malnutrition due to digestive disturbances or intestinalparasites, promoting blood circulation for regulating menstruation, removing toxicity for detumescence.Master has loose bowels, dysentery, infantile malnutrition due to digestive disturbances or intestinalparasites Disease, irregular menstruation, eczema, the ringworm of the foot, venomous snake bite.
Nephelium lappaceum：Sweet, sour, warm in nature；Returns spleen, stomach.Dissipates cold, only dysentery, removing toxic substances.Main dysentery, trusted subordinate's crymodynia, sore.
Broadbean pericarp：Bitter, puckery, mild-natured；The thoughts of returning home, Liver Channel.Hemostasis, sore.Main spitting of blood, bleeding from five sense organs or subcutaneous tissue, spit blood, have blood in stool, hematuria, Operative hemorrhage, burn and scald, epidemic blisters.
Mandarin orange leaf：Taste is pungent, hardship, mild-natured；Returns spleen, stomach, Liver Channel.Promoting the circulation of qi width chest, soothing liver and harmonizing stomach, removing toxicity for eliminating carbuncles.Main septum pectorale is full vexed, The distending pain in hypochondrium, blockage of menstruation, diaphragm carbuncle, acute mastitis, mammary cancer.
Climbing violet herb：Bitter, pungent, cold in nature；Return lung, Liver Channel.Clearing heat and detoxicating, scattered block up detumescence, cough-relieving.Main sore swollen toxin, eye is tied Film is scorching, cough with lung heat, pertussis, icteric hepatitis, herpes zoster, scald, traumatic injury, fracture, venomous snake bite.
Honey raisin tree seven：Bitter, mild-natured.Dispelling wind and removing obstruction in the meridians, eliminating stasis to subdue swelling.Main air pain of dampness syndrome, traumatic injury.
White Chloe：Taste is pungent, warm in nature.Promoting the circulation of qi is whetted the appetite.Main gastral cavity pain, indigestion.
Chicken gizzard dissipates：Bitter, pungent, mild-natured.Heat-clearing, dampness removing, removing toxic substances.Main cold, fever, sensible heat rush down dysentery, jaundice, difficult urination, Pin a word used for translation is rotten to itch, burn.
Buckwheat：Sweet, micro- acid, cold in nature；Returns spleen, stomach, large intestine channel.Invigorating the spleen disappears long-pending, lower gas width intestines, removing toxic substances sore.Main stomach Stagnant, have loose bowels, dysentery, twist intestinal cancer, white sand, under band, spontaneous perspiration, night sweat, bleb, erysipelas, ulcer, carbuncle on the back, scrofula disease, burn and scald.
Yunnan pleione tuber：Bitter, mild-natured.Tonifying lung, relieving cough and reducing sputum, hemostasia and promoting granulation.Control silicosis, pulmonary tuberculosis, pertussis, tracheae Inflammation, hemorrhage of digestive tract, carbuncle swells, traumatism and bleeding.《Yunnan Chinese herbal medicine choosing》Carry：" moistening lung, hemostasis.Control silicosis, pulmonary tuberculosis, tracheitis, Hemorrhage of digestive tract, traumatism and bleeding, furuncle, traumatic injury.”
The present invention compared with prior art, has the advantages that：
Chinese and Western medicine compound preparation of the present invention is combined by Chinese medicine and Western medicine and is formulated, have clearing away heat to stop bleeding, the long-pending dampness elimination that disappears, Effect of stomach strengthening and digestion promoting, all medicine phases are closed and can directly be reached diseased region, for treatment hemorrhage of digestive tract cause dizzy, nervous, The various symptoms such as cold sweat, weak, dry have the curative effect of uniqueness, and determined curative effect, quick result, and taking convenience is safe and reliable, Cost is relatively low, controls difficulty in relapse after healing.
Specific embodiment
With reference to specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese and Western medicine compound preparation active ingredient of the present invention and weight are：
Cimetidine 0.25g, Rebamipide 0.09g, Irsogladine 0.04g, bigleafbeautyberry root or leaf 21g, baccate sedge herb 21g, New Zealand spinach 20g, Clustered knotweed herb 20g, nephelium lappaceum 19g, broadbean pericarp 18g, mandarin orange leaf 18g, climbing violet herb 17g, honey raisin tree seven 17g, White Chloe 16g, chicken gizzard dissipates 16g, Buckwheat 15g and yunnan pleione tuber 14g.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, including the extraction work of following western medicine composition Skill step：
（1）Cimetidine is put in container, adds the ethanol of 1～2 times amount, dilution, be placed in microwave dryer with 5～8 DEG C Temperature low temperature drying, extraction is ground into powder, obtains the fine powder of 180 mesh, standby；
（2）Rebamipide and Irsogladine are put in medicinal cupping, is stirred with mixer, put into cold after 70 DEG C of baking oven is dried But, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
（3）By above-mentioned steps（1）~（2）The fine powder obtaining puts into mixing in container, and extraction is ground into powder, obtains the fine powder of 200 mesh, Standby.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, including the extraction work of following traditional Chinese medicine ingredients Skill step：
（1）Bigleafbeautyberry root or leaf, baccate sedge herb, New Zealand spinach and White Chloe are put in container, adds the distilled water of 5～8 times amount, heating boils 2 ～3 hours, extract, filter, obtain filtrate, heating is concentrated into pasty state, put into after 70 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains Cross the fine powder of 160 mesh, standby；
（2）Clustered knotweed herb, nephelium lappaceum, broadbean pericarp and buckwheat are put in container, adds the distilled water of 3～6 times amount, heating boils 1 ～2 hours, extract, filter, obtain filtrate, standby；
（3）Mandarin orange leaf, climbing violet herb and chicken gizzard are dissipated and cleans, chopping, put in container, twist juice, filter impurity, stay juice standby；
（4）Honey raisin tree seven is cleaned, immersion 3 times amount 60% alcohol solution dipping 1～2 hour, heating extraction 3 hours, reclaims second Alcohol, filtration, obtain filtrate, standby；
（5）Yunnan pleione tuber is put in container, carries out pulverization process, grind into powder, obtained the fine powder of 180 mesh, standby；
（6）By above-mentioned steps（1）~（5）The fine powder that obtains, filtrate and carry out juice mixing, after stirring and dissolving is uniform, heating is dense It is reduced to pasty state, put into after 60 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains the fine powder of 200 mesh, standby.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, by described Western medicine fine powder and traditional Chinese medicine fine powder Mixed, after stirring and dissolving is uniform, extracts and make tablet, obtained final product the Chinese and Western medicine compound system of described treatment hemorrhage of digestive tract Agent.
Usage and dosage：Oral, 2 times a day, and each 1 time sooner or later, 1 tablet once；It is within 5 days 1 course for the treatment of, 1～3 course for the treatment of can be fullyed recover from an illness More, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese and Western medicine compound preparation active ingredient of the present invention and weight are：
Cimetidine 0.2g, Rebamipide 0.08g, Irsogladine 0.03g, bigleafbeautyberry root or leaf 17g, baccate sedge herb 17g, New Zealand spinach 16g, clump Branch knotweed 16g, nephelium lappaceum 15g, broadbean pericarp 14g, mandarin orange leaf 14g, climbing violet herb 13g, honey raisin tree seven 13g, White Chloe 12g, chicken gizzard dissipates 12g, buckwheat Wheat 11g and yunnan pleione tuber 10g.
The Chinese and Western medicine compound preparation preparation method processing step of the present embodiment and usage and dosage are same as Example 1.
Embodiment 3
The raw material composition of Chinese and Western medicine compound preparation active ingredient of the present invention and weight are：
Cimetidine 0.15g, Rebamipide 0.07g, Irsogladine 0.02g, bigleafbeautyberry root or leaf 13g, baccate sedge herb 13g, New Zealand spinach 12g, Clustered knotweed herb 12g, nephelium lappaceum 11g, broadbean pericarp 10g, mandarin orange leaf 10g, climbing violet herb 9g, honey raisin tree seven 9g, White Chloe 8g, chicken gizzard dissipates 8g, buckwheat 7g and yunnan pleione tuber 6g.
The Chinese and Western medicine compound preparation preparation method processing step of the present embodiment and usage and dosage are same as Example 1.
Embodiment 4
The raw material composition of Chinese and Western medicine compound preparation active ingredient of the present invention and weight are：
Cimetidine 0.1g, Rebamipide 0.06g, Irsogladine 0.01g, bigleafbeautyberry root or leaf 9g, baccate sedge herb 9g, New Zealand spinach 8g, Cong Zhi Knotweed 8g, nephelium lappaceum 7g, broadbean pericarp 6g, mandarin orange leaf 6g, climbing violet herb 5g, honey raisin tree seven 5g, White Chloe 4g, chicken gizzard dissipates 4g, buckwheat 3g and only leaf Bletilla striata 2g.
The Chinese and Western medicine compound preparation preparation method processing step of the present embodiment and usage and dosage are same as Example 1.
Clinical data：
First, case selection：
As the Chinese and Western medicine compound preparation for the treatment of hemorrhage of digestive tract, select 294 clinical observations of Diagnosing Gastrointestinal Bleeding made a definite diagnosis, Patient is randomly divided into treatment group, control group A and tri- groups of control group B, treatment group 98, the wherein male sex 49, women 49, age 20～71 years old, average age 45.5 years old, average course of disease 1 year；Control group A 98, the wherein male sex 50, women 48, the age 21 ～70 years old, average age 45.5
Year, average course of disease 1 year；Control group B98 example, the wherein male sex 48, women 50,20～69 years old age, average age 44.5 years old, average course of disease 1 year.
The course of disease for the treatment of group, control group A and tri- groups of cases of control group B, degrees of symptoms are basically identical, no significance difference Different, there is comparativity.
2nd, medicament selection：
Treatment group uses Chinese and Western medicine compound preparation of the present invention, is administered orally, 2 times a day, and each 1 time sooner or later, 1 tablet once；It is within 5 days 1 treatment Journey, 1～3 course for the treatment of can be fully recovered, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Control group A takes omeprazole enteric-coated capsules, is administered orally, can not chew, a 20mg（Once a grain）, one day 1～2 Secondary, swallow from daily morning or sooner or later respectively once, the course for the treatment of is usually 4～8 weeks.
Control group B takes bismuth citrate k particle, is administered orally, is taken after mixing it with water with 30～50 milliliters of warm water.One time 1 bag of adult, one day 4 Secondary, 3 times half an hour before breakfast, lunch and dinner, the 4th is taken for 2 hours after dinner；Or 2 times a day, sooner or later respectively take 2 bags.
3rd, Outcome measure：
Cure：Dizzy, the nervous, symptom such as cold sweat, weak, dry occurs during hemorrhage of digestive tract all disappear, physical recovery is normal. Effective：Above-mentioned symptom is relieved, and body is clearly better.Effectively：Above-mentioned symptom has been alleviated, and body has taken a turn for the better.Invalid：Logical After crossing treatment, above-mentioned symptom is no alleviated or is increased.
4th, treatment results：
Result above shows, the cure rate for the treatment of group and total effective rate are apparently higher than control group A and control group B.
5th, model case：
1st, leaf, man, 27 years old.Patient's Nausea and vomiting, no substantially navel week secret anguish in inducement, removes hospital admission, is diagnosed as digesting Gastrointestinal hemorrhage, using drug therapy, therapeutic effect is general, and our hospital's treatment, controlled through taking Chinese and Western medicine compound preparation of the present invention later Treat, after taking 1 course for the treatment of, symptom substantially mitigates, and takes 2 treatments
Cheng Hou, symptom all disappears, recovery from illness, and follow-up after half a year is no recurred.
2nd, Xue, female, 39 years old.Row's bloody stool in the no obvious inducement of patient, with dizzy, malaise, admission examination, makes a definite diagnosis For hemorrhage of digestive tract, doctor gives Chinese and Western medicine compound preparation treatment of the present invention, and after taking 1 course for the treatment of, symptom is clearly better, and continues After taking 2 courses for the treatment of, all diseases disappear, recovery from illness, and follow-up after 1 year is no recurred.
3rd, the Yan, man, 45 years old.Patient is dizzy, weak, bloody stool symptom, removes examination in hospital, be diagnosed as digestion during defecation Gastrointestinal hemorrhage, doctor gives Chinese and Western medicine compound preparation treatment of the present invention, and after taking 1 course for the treatment of, symptom has taken a turn for the better, and takes 2 treatments Cheng Hou, symptom is clearly better, and after continuing to take 1 course for the treatment of, symptom all disappears, recovery from illness, and follow-up is not recurred so far.
4th, Pan, female, 56 years old.Row's kermesinus bloody stool in the no obvious inducement of patient, and with symptoms such as dizziness, cold sweat, Remove examination in hospital, be diagnosed as hemorrhage of digestive tract, doctor gives Chinese and Western medicine compound preparation treatment of the present invention, after taking 1 course for the treatment of, disease Shape has been alleviated, and after taking 2 courses for the treatment of, symptom is relieved, and after continuing to take 1 course for the treatment of, all diseases disappears, recovery from illness, after 1 year with Visit and no recur.
5th, Dai, man, 48 years old.Abdominal pain in the no obvious inducement of patient, in paroxysmal secret anguish, arranges melena, random thoughts are disliked The heart, and have dizziness, headache, weak symptom, remove examination in hospital, be diagnosed as hemorrhage of digestive tract, using excessively multiple drug therapy, treat Effect on driving birds is not good, by taking Chinese and Western medicine compound preparation treatment of the present invention, after taking 1 course for the treatment of, symptom substantially mitigates, and continues to take After 2 courses for the treatment of, symptom all disappears, recovery from illness, and follow-up after half a year is no recurred.
6th, shut out certain, female, 69 years old.The symptoms such as abdominal pain, n and V, dizzy spitting blood in the no obvious inducement of patient, and Line up shape melena, remove examination in hospital, be diagnosed as hemorrhage of digestive tract, doctor gives Chinese and Western medicine compound preparation treatment of the present invention, takes 1 After the individual course for the treatment of, symptom has mitigated, and after taking 2 courses for the treatment of, symptom substantially mitigates, and after continuing to take 1 course for the treatment of, symptom all disappears Lose, recovery from illness, follow-up is not recurred so far.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention is made with other forms, all It is without departing from technical solution of the present invention content, according to any modification made in the application range of the present invention, equivalent with change Enter, still fall within the protection domain of technical solution of the present invention.

Claims (6)

1. a kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract it is characterised in that：Making described Chinese and Western medicine compound preparation has The raw material composition of effect composition and parts by weight are：
0.1～0.3 part of Cimetidine, 0.06～0.1 part of Rebamipide, 0.01～0.05 part of Irsogladine, bigleafbeautyberry root or leaf 9～25 Part, 9～25 parts of baccate sedge herb, 8～24 parts of New Zealand spinach, 8～24 parts of clustered knotweed herb, 7～23 parts of nephelium lappaceum, 6～22 parts of broadbean pericarp, mandarin orange leaf 6 ～22 parts, 5～21 parts of climbing violet herb, 7 5～21 parts of honey raisin tree, 4～20 parts of White Chloe, chicken gizzard dissipates 4～20 parts, 3～19 parts of buckwheat and solely 2～18 parts of the leaf bletilla striata.
2. a kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract according to claim 1 it is characterised in that：Make institute State the raw material composition of Chinese and Western medicine compound preparation active ingredient and parts by weight are：
0.15～0.25 part of Cimetidine, 0.07～0.09 part of Rebamipide, 0.02～0.04 part of Irsogladine, bigleafbeautyberry root or leaf 13 ～21 parts, 13～21 parts of baccate sedge herb, 12～20 parts of New Zealand spinach, 12～20 parts of clustered knotweed herb, 11～19 parts of nephelium lappaceum, broadbean pericarp 10～18 Part, 10～18 parts of mandarin orange leaf, 9～17 parts of climbing violet herb, 7 9～17 parts of honey raisin tree, 8～16 parts of White Chloe, chicken gizzard dissipates 8～16 parts, buckwheat 7～ 15 parts and 6～14 parts of yunnan pleione tuber.
3. a kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract according to claim 1 it is characterised in that：Make institute State the raw material composition of Chinese and Western medicine compound preparation active ingredient and parts by weight are：
0.2 part of Cimetidine, 0.08 part of Rebamipide, 0.03 part of Irsogladine, 17 parts of bigleafbeautyberry root or leaf, 17 parts of baccate sedge herb, New Zealand spinach 16 parts, 16 parts of clustered knotweed herb, 15 parts of nephelium lappaceum, 14 parts of broadbean pericarp, 14 parts of mandarin orange leaf, 13 parts of climbing violet herb, 7 13 parts of honey raisin tree, White Chloe 12 Part, scattered 12 parts of chicken gizzard, 11 parts of buckwheat and 10 parts of yunnan pleione tuber.
4. as described in a kind of any one as Claims 1 to 4, treat the preparation method of the Chinese and Western medicine compound preparation of hemorrhage of digestive tract, its It is characterised by：Extraction process step including following western medicine composition：
（1）Cimetidine is put in container, adds the ethanol of 1～2 times amount, dilution, be placed in microwave dryer with 5～8 DEG C Temperature low temperature drying, extraction is ground into powder, obtains the fine powder of 180 mesh, standby；
（2）Rebamipide and Irsogladine are put in medicinal cupping, is stirred with mixer, put into baking oven
Cool down after 70 DEG C of drying, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
（3）By above-mentioned steps（1）~（2）The fine powder obtaining puts into mixing in container, and extraction is ground into powder, obtains the fine powder of 200 mesh, Standby.
5. as described in a kind of any one as Claims 1 to 4, treat the preparation method of the Chinese and Western medicine compound preparation of hemorrhage of digestive tract, its It is characterised by：Extraction process step including following traditional Chinese medicine ingredients：
（1）Bigleafbeautyberry root or leaf, baccate sedge herb, New Zealand spinach and White Chloe are put in container, adds the distilled water of 5～8 times amount, heating boils 2 ～3 hours, extract, filter, obtain filtrate, heating is concentrated into pasty state, put into after 70 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains Cross the fine powder of 160 mesh, standby；
（2）Clustered knotweed herb, nephelium lappaceum, broadbean pericarp and buckwheat are put in container, adds the distilled water of 3～6 times amount, heating boils 1 ～2 hours, extract, filter, obtain filtrate, standby；
（3）Mandarin orange leaf, climbing violet herb and chicken gizzard are dissipated and cleans, chopping, put in container, twist juice, filter impurity, stay juice standby；
（4）Honey raisin tree seven is cleaned, immersion 3 times amount 60% alcohol solution dipping 1～2 hour, heating extraction 3 hours, reclaims second Alcohol, filtration, obtain filtrate, standby；
（5）Yunnan pleione tuber is put in container, carries out pulverization process, grind into powder, obtained the fine powder of 180 mesh, standby；
（6）By above-mentioned steps（1）~（5）The fine powder that obtains, filtrate and carry out juice mixing, after stirring and dissolving is uniform, heating is dense It is reduced to pasty state, put into after 60 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains the fine powder of 200 mesh, standby.
6. treat the preparation method of the Chinese and Western medicine compound preparation of hemorrhage of digestive tract according to claim 4 or claim 5, its It is characterised by：Described Western medicine fine powder and traditional Chinese medicine fine powder are mixed, after stirring and dissolving is uniform, extracts and make tablet, obtain final product institute The Chinese and Western medicine compound preparation of the treatment hemorrhage of digestive tract stated.
CN201610924060.1A 2016-10-24 2016-10-24 Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and preparation method Pending CN106421600A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020014726A1 (en) * 2018-07-20 2020-01-23 Xenexus Pharmaceuticals Pty. Ltd. Treatment for liver regeneration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101461917A (en) * 2007-12-19 2009-06-24 丁月芳 Chinese medicine for treating hemorrhage of upper digestive tract
CN105031388A (en) * 2015-09-15 2015-11-11 徐玉田 Medicine for treating alimentary tract hemorrhage and preparing method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101461917A (en) * 2007-12-19 2009-06-24 丁月芳 Chinese medicine for treating hemorrhage of upper digestive tract
CN105031388A (en) * 2015-09-15 2015-11-11 徐玉田 Medicine for treating alimentary tract hemorrhage and preparing method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020014726A1 (en) * 2018-07-20 2020-01-23 Xenexus Pharmaceuticals Pty. Ltd. Treatment for liver regeneration

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