CN106421600A - Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and preparation method - Google Patents
Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and preparation method Download PDFInfo
- Publication number
- CN106421600A CN106421600A CN201610924060.1A CN201610924060A CN106421600A CN 106421600 A CN106421600 A CN 106421600A CN 201610924060 A CN201610924060 A CN 201610924060A CN 106421600 A CN106421600 A CN 106421600A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese
- western medicine
- compound preparation
- medicine compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 76
- 238000002360 preparation method Methods 0.000 title claims abstract description 61
- 150000001875 compounds Chemical class 0.000 title claims abstract description 46
- 208000032843 Hemorrhage Diseases 0.000 title abstract description 23
- ATCGGEJZONJOCL-UHFFFAOYSA-N 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC(N)=NC(C=2C(=CC=C(Cl)C=2)Cl)=N1 ATCGGEJZONJOCL-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000009419 Fagopyrum esculentum Nutrition 0.000 claims abstract description 15
- 244000183331 Nephelium lappaceum Species 0.000 claims abstract description 15
- 235000015738 Nephelium lappaceum Nutrition 0.000 claims abstract description 15
- 244000292697 Polygonum aviculare Species 0.000 claims abstract description 15
- 235000006386 Polygonum aviculare Nutrition 0.000 claims abstract description 15
- ALLWOAVDORUJLA-UHFFFAOYSA-N Rebamipida Chemical compound C=1C(=O)NC2=CC=CC=C2C=1CC(C(=O)O)NC(=O)C1=CC=C(Cl)C=C1 ALLWOAVDORUJLA-UHFFFAOYSA-N 0.000 claims abstract description 15
- 240000006677 Vicia faba Species 0.000 claims abstract description 15
- 235000010749 Vicia faba Nutrition 0.000 claims abstract description 15
- 235000002098 Vicia faba var. major Nutrition 0.000 claims abstract description 15
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229960001380 cimetidine Drugs 0.000 claims abstract description 15
- 230000009194 climbing Effects 0.000 claims abstract description 15
- 229950010984 irsogladine Drugs 0.000 claims abstract description 15
- 229950004535 rebamipide Drugs 0.000 claims abstract description 15
- 230000000694 effects Effects 0.000 claims abstract description 13
- 241001250596 Pleione Species 0.000 claims abstract description 12
- 240000008620 Fagopyrum esculentum Species 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims description 49
- 238000011282 treatment Methods 0.000 claims description 42
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 claims description 38
- 238000000605 extraction Methods 0.000 claims description 24
- 238000010438 heat treatment Methods 0.000 claims description 16
- 241001290610 Abildgaardia Species 0.000 claims description 14
- 241001672694 Citrus reticulata Species 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 244000118681 Iresine herbstii Species 0.000 claims description 14
- 244000294947 Tetragonia tetragonoides Species 0.000 claims description 14
- 235000004472 Tetragonia tetragonoides Nutrition 0.000 claims description 14
- 240000006365 Vitis vinifera Species 0.000 claims description 14
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 14
- 235000012907 honey Nutrition 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 239000000706 filtrate Substances 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 7
- 239000012153 distilled water Substances 0.000 claims description 6
- 235000011837 pasties Nutrition 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 241001313857 Bletilla striata Species 0.000 claims description 3
- 238000010790 dilution Methods 0.000 claims description 3
- 239000012895 dilution Substances 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 208000024891 symptom Diseases 0.000 abstract description 27
- 230000000740 bleeding effect Effects 0.000 abstract description 18
- 208000002173 dizziness Diseases 0.000 abstract description 10
- 210000002784 stomach Anatomy 0.000 abstract description 10
- 230000001737 promoting effect Effects 0.000 abstract description 8
- 206010009866 Cold sweat Diseases 0.000 abstract description 6
- 230000029087 digestion Effects 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 4
- 241001461179 Callicarpa macrophylla Species 0.000 abstract 1
- 241000986012 Carex baccans Species 0.000 abstract 1
- 241000207199 Citrus Species 0.000 abstract 1
- 240000002943 Elettaria cardamomum Species 0.000 abstract 1
- 241000119904 Elsholtzia blanda Species 0.000 abstract 1
- 241001247806 Hylomecon japonica Species 0.000 abstract 1
- 241000191418 Tetragonia <angiosperm> Species 0.000 abstract 1
- 235000005300 cardamomo Nutrition 0.000 abstract 1
- 235000020971 citrus fruits Nutrition 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 18
- 208000034158 bleeding Diseases 0.000 description 17
- 201000010099 disease Diseases 0.000 description 17
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 241000219051 Fagopyrum Species 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 7
- 230000036407 pain Effects 0.000 description 7
- 238000011084 recovery Methods 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 208000001848 dysentery Diseases 0.000 description 5
- 208000035861 hematochezia Diseases 0.000 description 5
- 230000023597 hemostasis Effects 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 4
- 208000007882 Gastritis Diseases 0.000 description 4
- 206010029216 Nervousness Diseases 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 230000008736 traumatic injury Effects 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 201000005702 Pertussis Diseases 0.000 description 3
- 208000007107 Stomach Ulcer Diseases 0.000 description 3
- 206010053615 Thermal burn Diseases 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- 208000027503 bloody stool Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 210000001198 duodenum Anatomy 0.000 description 3
- 201000005917 gastric ulcer Diseases 0.000 description 3
- 230000000302 ischemic effect Effects 0.000 description 3
- 206010033675 panniculitis Diseases 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 210000000697 sensory organ Anatomy 0.000 description 3
- 230000035939 shock Effects 0.000 description 3
- 210000004304 subcutaneous tissue Anatomy 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000004232 Enteritis Diseases 0.000 description 2
- 208000007514 Herpes zoster Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 2
- 208000015817 Infant Nutrition disease Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 201000010001 Silicosis Diseases 0.000 description 2
- 208000004078 Snake Bites Diseases 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 208000009443 Vascular Malformations Diseases 0.000 description 2
- 210000000436 anus Anatomy 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 208000023652 chronic gastritis Diseases 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 239000000403 digestive tract agent Substances 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000030304 gastrointestinal bleeding Diseases 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 208000028774 intestinal disease Diseases 0.000 description 2
- 244000000053 intestinal parasite Species 0.000 description 2
- 210000001630 jejunum Anatomy 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 210000001809 melena Anatomy 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 231100000611 venom Toxicity 0.000 description 2
- KKMOSYLWYLMHAL-UHFFFAOYSA-N 2-bromo-6-nitroaniline Chemical compound NC1=C(Br)C=CC=C1[N+]([O-])=O KKMOSYLWYLMHAL-UHFFFAOYSA-N 0.000 description 1
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010002153 Anal fissure Diseases 0.000 description 1
- 208000016583 Anus disease Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000252983 Caecum Species 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010013554 Diverticulum Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000009531 Fissure in Ano Diseases 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010061164 Gastric mucosal lesion Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 description 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
- 206010022653 Intestinal haemorrhages Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 206010071229 Procedural haemorrhage Diseases 0.000 description 1
- 206010036774 Proctitis Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010049771 Shock haemorrhagic Diseases 0.000 description 1
- 206010041519 Spider naevus Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 241000893966 Trichophyton verrucosum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 206010052568 Urticaria chronic Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000003815 abdominal wall Anatomy 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009798 acute exacerbation Effects 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 208000034526 bruise Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 208000024376 chronic urticaria Diseases 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 208000007784 diverticulitis Diseases 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 201000011066 hemangioma Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
- 208000003243 intestinal obstruction Diseases 0.000 description 1
- 201000008267 intestinal tuberculosis Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 208000001118 melena Diseases 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 229960000381 omeprazole Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001314 paroxysmal effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035485 pulse pressure Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and a preparation method, which belong to the technical field of medicines. The Chinese-Western medicine compound preparation is prepared from the following effective constituents: cimetidine, rebamipide, irsogladine, callicarpa macrophylla, carex baccans seed, common tetragonia herb, clustered knotweed herb, nephelium lappaceum, broadbean pericarp, chachi citrus leaf, climbing violet herb, hylomecon japonica, cardamom, elsholtzia blanda benth, buckwheat and Yunnan pleione tuber. The Chinese-Western medicine compound preparation provided by the invention is prepared from combining traditional Chinese medicine and Western medicine, has the efficacy on clearing heat and stop bleeding, removing food retention and resolving dampness, invigorating stomach and promoting digestion, can directly arrive a diseased region through compatibility of various medicines, has a unique curative effect on treating various symptoms such as dizziness, flusteredness, cold sweat, weakness and thirsty caused by alimentary tract hemorrhage, and is obvious in curative effect, faster in effect, convenient to take, safe and reliable, lower in cost, and not easy to recur after cure.
Description
Art
The present invention relates to pharmaceutical technology field, more particularly, to a kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract and system
Preparation Method.
Background technology
Hemorrhage of digestive tract is clinical common syndrome, can be caused by multiple diseases, and alimentary canal refers to from oesophagus to anus
Pipeline, including oesophagus, Stomach duodenum, jejunum, ileum, caecum, colon and rectum.UGB refers to duodenum
Oesophagus more than suspensorium, the bleeding of Stomach duodenum, epimere jejunum and ductus pancreaticus and bile duct, below ligament of Treitz
Intestinal bleeding be referred to as hemorrhage of lower digestive tract.
Hemorrhage of digestive tract can cause because of factors such as the inflammation of alimentary canal itself, mechanical injuries, vascular lesion, tumours,
Caused by alimentary canal being involved because of the pathology of adjacent organs and systemic disease.In, hemorrhage of lower digestive tract：Anal tube disease hemorrhoid, anal fissure,
Anal fistula；Recial disease proctitis ulcerosa, tumour, class cancer, neighbouring malignant tumour or abscess invade rectum, infection, ischemic etc.；Knot
Intestinal disease infection, ulcerative colitis, diverticulum, tumour, ischemic and vascular malformation, entembole etc.；Disease of intestine acute hemorrhagic
Necrotic enteritis, intestinal tuberculosis, Crohn disease, diverticulitis or ulcer, entembole, tumour, hemangioma, vascular malformation, ischemic etc..
Different according to bleeding part and amount of bleeding, bleeding rate, clinical manifestation is different.General status are in a small amount（400ml with
Under）, no obvious subjective symptoms more than chronic bleeding.Acute, dizzy, the nervous, disease such as cold sweat, weak, dry occurs when bleeding profusely
Shape, even faint, the symptom such as four limbs are ice-cold, oliguria, dysphoria, shock.Vital sign：Pulse and blood pressure change are journeys of losing blood
The important indicator of degree.During acute gastrointestinal bleeding, blood volume falls sharply, and initial body compensation is increased heart rate, if can not
, shock state then acrotism, or even lay one's hand on unclear in hemostasis or replenishment of blood content in time.Shock early stage blood pressure can be with compensatory
Raise, increase with amount of bleeding, blood pressure is gradually reduced, enter hemorrhagic shock.Other simultaneous phenomenons and sign：According to former
Send out the difference of disease, can with other corresponding clinical manifestations, such as stomachache, heating, intestinal obstruction, spitting blood, have blood in stool, tarry stool,
Abdominal mass, spider angioma, subcutaneous varicos vein of abdominal wall, jaundice etc..
At present treatment hemorrhage of digestive tract nothing more than Chinese medicine and two kinds of Western medicine, western medicine quick result, but drug-dependent
By force, cure the symptoms, not the disease, and expensive, and treatment by Chinese herbs take effect relatively slow, the course for the treatment of longer it is impossible to fundamentally release the pain of patient
Bitter.
Content of the invention
The invention provides a kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract and preparation method；Chinese and Western medicine of the present invention
Compound preparation is combined by Chinese medicine and Western medicine and is formulated, and has functions that clearing away heat to stop bleeding, disappear long-pending dampness elimination, stomach strengthening and digestion promoting,
All medicine phases are closed and can directly be reached diseased region, dizzy, nervous, cold sweat, the weak, dry etc. causing for treatment hemorrhage of digestive tract
Various symptoms have the curative effect of uniqueness, and determined curative effect, quick result, taking convenience, and safe and reliable, cost is relatively low, after healing
It is difficult to recur.
For achieving the above object, technical scheme enforcement is as follows：
A kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, makes the raw material group of described Chinese and Western medicine compound preparation active ingredient
Become and parts by weight are：
0.1～0.3 part of Cimetidine, 0.06～0.1 part of Rebamipide, 0.01～0.05 part of Irsogladine, bigleafbeautyberry root or leaf 9～25
Part, 9～25 parts of baccate sedge herb, 8～24 parts of New Zealand spinach, 8～24 parts of clustered knotweed herb, 7～23 parts of nephelium lappaceum, 6～22 parts of broadbean pericarp, mandarin orange leaf 6
～22 parts, 5～21 parts of climbing violet herb, 7 5～21 parts of honey raisin tree, 4～20 parts of White Chloe, chicken gizzard dissipates 4～20 parts, 3～19 parts of buckwheat and solely
2～18 parts of the leaf bletilla striata.
Make the raw material composition of described Chinese and Western medicine compound preparation active ingredient and parts by weight are：
0.15～0.25 part of Cimetidine, 0.07～0.09 part of Rebamipide, 0.02～0.04 part of Irsogladine, bigleafbeautyberry root or leaf 13
～21 parts, 13～21 parts of baccate sedge herb, 12～20 parts of New Zealand spinach, 12～20 parts of clustered knotweed herb, 11～19 parts of nephelium lappaceum, broadbean pericarp 10～18
Part, 10～18 parts of mandarin orange leaf, 9～17 parts of climbing violet herb, 7 9～17 parts of honey raisin tree, 8～16 parts of White Chloe, chicken gizzard dissipates 8～16 parts, buckwheat 7～
15 parts and 6～14 parts of yunnan pleione tuber.
Make the raw material composition of described Chinese and Western medicine compound preparation active ingredient and parts by weight are：
0.2 part of Cimetidine, 0.08 part of Rebamipide, 0.03 part of Irsogladine, 17 parts of bigleafbeautyberry root or leaf, 17 parts of baccate sedge herb, New Zealand spinach
16 parts, 16 parts of clustered knotweed herb, 15 parts of nephelium lappaceum, 14 parts of broadbean pericarp, 14 parts of mandarin orange leaf, 13 parts of climbing violet herb, 7 13 parts of honey raisin tree, White Chloe 12
Part, scattered 12 parts of chicken gizzard, 11 parts of buckwheat and 10 parts of yunnan pleione tuber.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, including the extraction work of following western medicine composition
Skill step：
（1）Cimetidine is put in container, adds the ethanol of 1～2 times amount, dilution, be placed in microwave dryer with 5～8 DEG C
Temperature low temperature drying, extraction is ground into powder, obtains the fine powder of 180 mesh, standby；
（2）Rebamipide and Irsogladine are put in medicinal cupping, is stirred with mixer, put into cold after 70 DEG C of baking oven is dried
But, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
（3）By above-mentioned steps（1）~（2）The fine powder obtaining puts into mixing in container, and extraction is ground into powder, obtains the fine powder of 200 mesh,
Standby.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, including the extraction work of following traditional Chinese medicine ingredients
Skill step：
（1）Bigleafbeautyberry root or leaf, baccate sedge herb, New Zealand spinach and White Chloe are put in container, adds the distilled water of 5～8 times amount, heating boils 2
～3 hours, extract, filter, obtain filtrate, heating is concentrated into pasty state, put into after 70 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains
Cross the fine powder of 160 mesh, standby；
（2）Clustered knotweed herb, nephelium lappaceum, broadbean pericarp and buckwheat are put in container, adds the distilled water of 3～6 times amount, heating boils 1
～2 hours, extract, filter, obtain filtrate, standby；
（3）Mandarin orange leaf, climbing violet herb and chicken gizzard are dissipated and cleans, chopping, put in container, twist juice, filter impurity, stay juice standby；
（4）Honey raisin tree seven is cleaned, immersion 3 times amount 60% alcohol solution dipping 1～2 hour, heating extraction 3 hours, reclaims second
Alcohol, filtration, obtain filtrate, standby；
（5）Yunnan pleione tuber is put in container, carries out pulverization process, grind into powder, obtained the fine powder of 180 mesh, standby；
（6）By above-mentioned steps（1）~（5）The fine powder that obtains, filtrate and carry out juice mixing, after stirring and dissolving is uniform, heating is dense
It is reduced to pasty state, put into after 60 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains the fine powder of 200 mesh, standby.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, by described Western medicine fine powder and traditional Chinese medicine fine powder
Mixed, after stirring and dissolving is uniform, extracts and make tablet, obtained final product the Chinese and Western medicine compound system of described treatment hemorrhage of digestive tract
Agent.
The property of medicine of Chinese and Western medicine used by the present invention is as follows：
Cimetidine：For white or off-white color crystalline powder；Almost odorless, bitter.Readily soluble in methyl alcohol, molten in ethanol
Solution, slightly molten in isopropanol, slightly soluble in water, readily soluble in watery hydrochloric acid.For treat duodenal ulcer, gastric ulcer, on disappear
Change gastrointestinal hemorrhage, chronic colitis, herpes zoster, the disease such as chronic urticaria.Antiviral and Immune-enhancing effect are had certain effect.
Rebamipide：It is mainly used in the Acute Exacerbation Period gastric mucosal lesion of gastric ulcer, acute gastritis and chronic gastritis（Rotten
Rotten, bleeding, hyperemia, oedema）Improvement.
Irsogladine：For gastric ulcer, it is also used for improving the gastric mucosa disease of acute gastritis and chronic gastritis acute attack stage
Become（Erosion, bleeding, hyperemia, oedema etc.）.
Bigleafbeautyberry root or leaf：Taste is pungent, hardship, mild-natured；The thoughts of returning home, lung channel.Dissipate stasis of blood hemostasis, swelling and pain relieving.Main spitting of blood, bleeding from five sense organs or subcutaneous tissue, spit blood, just
Blood, traumatic bleeding, bruise is swollen, arthralgia due to wind-dampness.Guangzhou army《Conventional Chinese herbal medicine handbook》Carry：" hemostasis, pain relieving, eliminating stasis to subdue swelling.
Control hemorrhage of digestive tract, spitting of blood, bleeding from five sense organs or subcutaneous tissue, traumatic bleeding, bleeding of having tooth pulled out, treating swelling and pain by traumatic injury, treating rheumatic ostealgia.”
Baccate sedge herb：Sweet, micro-pungent, mild-natured；Return liver warp.Promoting eruption cough-relieving, bowl spares Li Shui.Djumah rash, varicella, pertussis, prolapse of the anus, float
Swollen.
New Zealand spinach：Sweet, micro-pungent, mild-natured；Return lung, liver, large intestine channel.Wind and heat dispersing, removing toxicity for detumescence.The hot hot eyes of main air, treats sore
Swell and ache, enteritis, septicemia, tumour.
Clustered knotweed herb：Taste is pungent, mild-natured.Heat-clearing and damp-drying drug, invigorating the spleen disappears infantile malnutrition due to digestive disturbances or intestinalparasites, promoting blood circulation for regulating menstruation, removing toxicity for detumescence.Master has loose bowels, dysentery, infantile malnutrition due to digestive disturbances or intestinalparasites
Disease, irregular menstruation, eczema, the ringworm of the foot, venomous snake bite.
Nephelium lappaceum：Sweet, sour, warm in nature；Returns spleen, stomach.Dissipates cold, only dysentery, removing toxic substances.Main dysentery, trusted subordinate's crymodynia, sore.
Broadbean pericarp：Bitter, puckery, mild-natured；The thoughts of returning home, Liver Channel.Hemostasis, sore.Main spitting of blood, bleeding from five sense organs or subcutaneous tissue, spit blood, have blood in stool, hematuria,
Operative hemorrhage, burn and scald, epidemic blisters.
Mandarin orange leaf：Taste is pungent, hardship, mild-natured；Returns spleen, stomach, Liver Channel.Promoting the circulation of qi width chest, soothing liver and harmonizing stomach, removing toxicity for eliminating carbuncles.Main septum pectorale is full vexed,
The distending pain in hypochondrium, blockage of menstruation, diaphragm carbuncle, acute mastitis, mammary cancer.
Climbing violet herb：Bitter, pungent, cold in nature；Return lung, Liver Channel.Clearing heat and detoxicating, scattered block up detumescence, cough-relieving.Main sore swollen toxin, eye is tied
Film is scorching, cough with lung heat, pertussis, icteric hepatitis, herpes zoster, scald, traumatic injury, fracture, venomous snake bite.
Honey raisin tree seven：Bitter, mild-natured.Dispelling wind and removing obstruction in the meridians, eliminating stasis to subdue swelling.Main air pain of dampness syndrome, traumatic injury.
White Chloe：Taste is pungent, warm in nature.Promoting the circulation of qi is whetted the appetite.Main gastral cavity pain, indigestion.
Chicken gizzard dissipates：Bitter, pungent, mild-natured.Heat-clearing, dampness removing, removing toxic substances.Main cold, fever, sensible heat rush down dysentery, jaundice, difficult urination,
Pin a word used for translation is rotten to itch, burn.
Buckwheat：Sweet, micro- acid, cold in nature；Returns spleen, stomach, large intestine channel.Invigorating the spleen disappears long-pending, lower gas width intestines, removing toxic substances sore.Main stomach
Stagnant, have loose bowels, dysentery, twist intestinal cancer, white sand, under band, spontaneous perspiration, night sweat, bleb, erysipelas, ulcer, carbuncle on the back, scrofula disease, burn and scald.
Yunnan pleione tuber：Bitter, mild-natured.Tonifying lung, relieving cough and reducing sputum, hemostasia and promoting granulation.Control silicosis, pulmonary tuberculosis, pertussis, tracheae
Inflammation, hemorrhage of digestive tract, carbuncle swells, traumatism and bleeding.《Yunnan Chinese herbal medicine choosing》Carry：" moistening lung, hemostasis.Control silicosis, pulmonary tuberculosis, tracheitis,
Hemorrhage of digestive tract, traumatism and bleeding, furuncle, traumatic injury.”
The present invention compared with prior art, has the advantages that：
Chinese and Western medicine compound preparation of the present invention is combined by Chinese medicine and Western medicine and is formulated, have clearing away heat to stop bleeding, the long-pending dampness elimination that disappears,
Effect of stomach strengthening and digestion promoting, all medicine phases are closed and can directly be reached diseased region, for treatment hemorrhage of digestive tract cause dizzy, nervous,
The various symptoms such as cold sweat, weak, dry have the curative effect of uniqueness, and determined curative effect, quick result, and taking convenience is safe and reliable,
Cost is relatively low, controls difficulty in relapse after healing.
Specific embodiment
With reference to specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese and Western medicine compound preparation active ingredient of the present invention and weight are：
Cimetidine 0.25g, Rebamipide 0.09g, Irsogladine 0.04g, bigleafbeautyberry root or leaf 21g, baccate sedge herb 21g, New Zealand spinach 20g,
Clustered knotweed herb 20g, nephelium lappaceum 19g, broadbean pericarp 18g, mandarin orange leaf 18g, climbing violet herb 17g, honey raisin tree seven 17g, White Chloe 16g, chicken gizzard dissipates 16g,
Buckwheat 15g and yunnan pleione tuber 14g.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, including the extraction work of following western medicine composition
Skill step：
（1）Cimetidine is put in container, adds the ethanol of 1～2 times amount, dilution, be placed in microwave dryer with 5～8 DEG C
Temperature low temperature drying, extraction is ground into powder, obtains the fine powder of 180 mesh, standby；
（2）Rebamipide and Irsogladine are put in medicinal cupping, is stirred with mixer, put into cold after 70 DEG C of baking oven is dried
But, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
（3）By above-mentioned steps（1）~（2）The fine powder obtaining puts into mixing in container, and extraction is ground into powder, obtains the fine powder of 200 mesh,
Standby.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, including the extraction work of following traditional Chinese medicine ingredients
Skill step：
（1）Bigleafbeautyberry root or leaf, baccate sedge herb, New Zealand spinach and White Chloe are put in container, adds the distilled water of 5～8 times amount, heating boils 2
～3 hours, extract, filter, obtain filtrate, heating is concentrated into pasty state, put into after 70 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains
Cross the fine powder of 160 mesh, standby；
（2）Clustered knotweed herb, nephelium lappaceum, broadbean pericarp and buckwheat are put in container, adds the distilled water of 3～6 times amount, heating boils 1
～2 hours, extract, filter, obtain filtrate, standby；
（3）Mandarin orange leaf, climbing violet herb and chicken gizzard are dissipated and cleans, chopping, put in container, twist juice, filter impurity, stay juice standby；
（4）Honey raisin tree seven is cleaned, immersion 3 times amount 60% alcohol solution dipping 1～2 hour, heating extraction 3 hours, reclaims second
Alcohol, filtration, obtain filtrate, standby；
（5）Yunnan pleione tuber is put in container, carries out pulverization process, grind into powder, obtained the fine powder of 180 mesh, standby；
（6）By above-mentioned steps（1）~（5）The fine powder that obtains, filtrate and carry out juice mixing, after stirring and dissolving is uniform, heating is dense
It is reduced to pasty state, put into after 60 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains the fine powder of 200 mesh, standby.
A kind of preparation method of the Chinese and Western medicine compound preparation treating hemorrhage of digestive tract, by described Western medicine fine powder and traditional Chinese medicine fine powder
Mixed, after stirring and dissolving is uniform, extracts and make tablet, obtained final product the Chinese and Western medicine compound system of described treatment hemorrhage of digestive tract
Agent.
Usage and dosage：Oral, 2 times a day, and each 1 time sooner or later, 1 tablet once；It is within 5 days 1 course for the treatment of, 1～3 course for the treatment of can be fullyed recover from an illness
More, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese and Western medicine compound preparation active ingredient of the present invention and weight are：
Cimetidine 0.2g, Rebamipide 0.08g, Irsogladine 0.03g, bigleafbeautyberry root or leaf 17g, baccate sedge herb 17g, New Zealand spinach 16g, clump
Branch knotweed 16g, nephelium lappaceum 15g, broadbean pericarp 14g, mandarin orange leaf 14g, climbing violet herb 13g, honey raisin tree seven 13g, White Chloe 12g, chicken gizzard dissipates 12g, buckwheat
Wheat 11g and yunnan pleione tuber 10g.
The Chinese and Western medicine compound preparation preparation method processing step of the present embodiment and usage and dosage are same as Example 1.
Embodiment 3
The raw material composition of Chinese and Western medicine compound preparation active ingredient of the present invention and weight are：
Cimetidine 0.15g, Rebamipide 0.07g, Irsogladine 0.02g, bigleafbeautyberry root or leaf 13g, baccate sedge herb 13g, New Zealand spinach 12g,
Clustered knotweed herb 12g, nephelium lappaceum 11g, broadbean pericarp 10g, mandarin orange leaf 10g, climbing violet herb 9g, honey raisin tree seven 9g, White Chloe 8g, chicken gizzard dissipates 8g, buckwheat
7g and yunnan pleione tuber 6g.
The Chinese and Western medicine compound preparation preparation method processing step of the present embodiment and usage and dosage are same as Example 1.
Embodiment 4
The raw material composition of Chinese and Western medicine compound preparation active ingredient of the present invention and weight are：
Cimetidine 0.1g, Rebamipide 0.06g, Irsogladine 0.01g, bigleafbeautyberry root or leaf 9g, baccate sedge herb 9g, New Zealand spinach 8g, Cong Zhi
Knotweed 8g, nephelium lappaceum 7g, broadbean pericarp 6g, mandarin orange leaf 6g, climbing violet herb 5g, honey raisin tree seven 5g, White Chloe 4g, chicken gizzard dissipates 4g, buckwheat 3g and only leaf
Bletilla striata 2g.
The Chinese and Western medicine compound preparation preparation method processing step of the present embodiment and usage and dosage are same as Example 1.
Clinical data：
First, case selection：
As the Chinese and Western medicine compound preparation for the treatment of hemorrhage of digestive tract, select 294 clinical observations of Diagnosing Gastrointestinal Bleeding made a definite diagnosis,
Patient is randomly divided into treatment group, control group A and tri- groups of control group B, treatment group 98, the wherein male sex 49, women 49, age
20～71 years old, average age 45.5 years old, average course of disease 1 year；Control group A 98, the wherein male sex 50, women 48, the age 21
～70 years old, average age 45.5
Year, average course of disease 1 year；Control group B98 example, the wherein male sex 48, women 50,20～69 years old age, average age
44.5 years old, average course of disease 1 year.
The course of disease for the treatment of group, control group A and tri- groups of cases of control group B, degrees of symptoms are basically identical, no significance difference
Different, there is comparativity.
2nd, medicament selection：
Treatment group uses Chinese and Western medicine compound preparation of the present invention, is administered orally, 2 times a day, and each 1 time sooner or later, 1 tablet once；It is within 5 days 1 treatment
Journey, 1～3 course for the treatment of can be fully recovered, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Control group A takes omeprazole enteric-coated capsules, is administered orally, can not chew, a 20mg（Once a grain）, one day 1～2
Secondary, swallow from daily morning or sooner or later respectively once, the course for the treatment of is usually 4～8 weeks.
Control group B takes bismuth citrate k particle, is administered orally, is taken after mixing it with water with 30～50 milliliters of warm water.One time 1 bag of adult, one day 4
Secondary, 3 times half an hour before breakfast, lunch and dinner, the 4th is taken for 2 hours after dinner；Or 2 times a day, sooner or later respectively take 2 bags.
3rd, Outcome measure：
Cure：Dizzy, the nervous, symptom such as cold sweat, weak, dry occurs during hemorrhage of digestive tract all disappear, physical recovery is normal.
Effective：Above-mentioned symptom is relieved, and body is clearly better.Effectively：Above-mentioned symptom has been alleviated, and body has taken a turn for the better.Invalid：Logical
After crossing treatment, above-mentioned symptom is no alleviated or is increased.
4th, treatment results：
Result above shows, the cure rate for the treatment of group and total effective rate are apparently higher than control group A and control group B.
5th, model case：
1st, leaf, man, 27 years old.Patient's Nausea and vomiting, no substantially navel week secret anguish in inducement, removes hospital admission, is diagnosed as digesting
Gastrointestinal hemorrhage, using drug therapy, therapeutic effect is general, and our hospital's treatment, controlled through taking Chinese and Western medicine compound preparation of the present invention later
Treat, after taking 1 course for the treatment of, symptom substantially mitigates, and takes 2 treatments
Cheng Hou, symptom all disappears, recovery from illness, and follow-up after half a year is no recurred.
2nd, Xue, female, 39 years old.Row's bloody stool in the no obvious inducement of patient, with dizzy, malaise, admission examination, makes a definite diagnosis
For hemorrhage of digestive tract, doctor gives Chinese and Western medicine compound preparation treatment of the present invention, and after taking 1 course for the treatment of, symptom is clearly better, and continues
After taking 2 courses for the treatment of, all diseases disappear, recovery from illness, and follow-up after 1 year is no recurred.
3rd, the Yan, man, 45 years old.Patient is dizzy, weak, bloody stool symptom, removes examination in hospital, be diagnosed as digestion during defecation
Gastrointestinal hemorrhage, doctor gives Chinese and Western medicine compound preparation treatment of the present invention, and after taking 1 course for the treatment of, symptom has taken a turn for the better, and takes 2 treatments
Cheng Hou, symptom is clearly better, and after continuing to take 1 course for the treatment of, symptom all disappears, recovery from illness, and follow-up is not recurred so far.
4th, Pan, female, 56 years old.Row's kermesinus bloody stool in the no obvious inducement of patient, and with symptoms such as dizziness, cold sweat,
Remove examination in hospital, be diagnosed as hemorrhage of digestive tract, doctor gives Chinese and Western medicine compound preparation treatment of the present invention, after taking 1 course for the treatment of, disease
Shape has been alleviated, and after taking 2 courses for the treatment of, symptom is relieved, and after continuing to take 1 course for the treatment of, all diseases disappears, recovery from illness, after 1 year with
Visit and no recur.
5th, Dai, man, 48 years old.Abdominal pain in the no obvious inducement of patient, in paroxysmal secret anguish, arranges melena, random thoughts are disliked
The heart, and have dizziness, headache, weak symptom, remove examination in hospital, be diagnosed as hemorrhage of digestive tract, using excessively multiple drug therapy, treat
Effect on driving birds is not good, by taking Chinese and Western medicine compound preparation treatment of the present invention, after taking 1 course for the treatment of, symptom substantially mitigates, and continues to take
After 2 courses for the treatment of, symptom all disappears, recovery from illness, and follow-up after half a year is no recurred.
6th, shut out certain, female, 69 years old.The symptoms such as abdominal pain, n and V, dizzy spitting blood in the no obvious inducement of patient, and
Line up shape melena, remove examination in hospital, be diagnosed as hemorrhage of digestive tract, doctor gives Chinese and Western medicine compound preparation treatment of the present invention, takes 1
After the individual course for the treatment of, symptom has mitigated, and after taking 2 courses for the treatment of, symptom substantially mitigates, and after continuing to take 1 course for the treatment of, symptom all disappears
Lose, recovery from illness, follow-up is not recurred so far.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention is made with other forms, all
It is without departing from technical solution of the present invention content, according to any modification made in the application range of the present invention, equivalent with change
Enter, still fall within the protection domain of technical solution of the present invention.
Claims (6)
1. a kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract it is characterised in that：Making described Chinese and Western medicine compound preparation has
The raw material composition of effect composition and parts by weight are：
0.1～0.3 part of Cimetidine, 0.06～0.1 part of Rebamipide, 0.01～0.05 part of Irsogladine, bigleafbeautyberry root or leaf 9～25
Part, 9～25 parts of baccate sedge herb, 8～24 parts of New Zealand spinach, 8～24 parts of clustered knotweed herb, 7～23 parts of nephelium lappaceum, 6～22 parts of broadbean pericarp, mandarin orange leaf 6
～22 parts, 5～21 parts of climbing violet herb, 7 5～21 parts of honey raisin tree, 4～20 parts of White Chloe, chicken gizzard dissipates 4～20 parts, 3～19 parts of buckwheat and solely
2～18 parts of the leaf bletilla striata.
2. a kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract according to claim 1 it is characterised in that：Make institute
State the raw material composition of Chinese and Western medicine compound preparation active ingredient and parts by weight are：
0.15～0.25 part of Cimetidine, 0.07～0.09 part of Rebamipide, 0.02～0.04 part of Irsogladine, bigleafbeautyberry root or leaf 13
～21 parts, 13～21 parts of baccate sedge herb, 12～20 parts of New Zealand spinach, 12～20 parts of clustered knotweed herb, 11～19 parts of nephelium lappaceum, broadbean pericarp 10～18
Part, 10～18 parts of mandarin orange leaf, 9～17 parts of climbing violet herb, 7 9～17 parts of honey raisin tree, 8～16 parts of White Chloe, chicken gizzard dissipates 8～16 parts, buckwheat 7～
15 parts and 6～14 parts of yunnan pleione tuber.
3. a kind of Chinese and Western medicine compound preparation treating hemorrhage of digestive tract according to claim 1 it is characterised in that：Make institute
State the raw material composition of Chinese and Western medicine compound preparation active ingredient and parts by weight are：
0.2 part of Cimetidine, 0.08 part of Rebamipide, 0.03 part of Irsogladine, 17 parts of bigleafbeautyberry root or leaf, 17 parts of baccate sedge herb, New Zealand spinach
16 parts, 16 parts of clustered knotweed herb, 15 parts of nephelium lappaceum, 14 parts of broadbean pericarp, 14 parts of mandarin orange leaf, 13 parts of climbing violet herb, 7 13 parts of honey raisin tree, White Chloe 12
Part, scattered 12 parts of chicken gizzard, 11 parts of buckwheat and 10 parts of yunnan pleione tuber.
4. as described in a kind of any one as Claims 1 to 4, treat the preparation method of the Chinese and Western medicine compound preparation of hemorrhage of digestive tract, its
It is characterised by：Extraction process step including following western medicine composition：
（1）Cimetidine is put in container, adds the ethanol of 1～2 times amount, dilution, be placed in microwave dryer with 5～8 DEG C
Temperature low temperature drying, extraction is ground into powder, obtains the fine powder of 180 mesh, standby；
（2）Rebamipide and Irsogladine are put in medicinal cupping, is stirred with mixer, put into baking oven
Cool down after 70 DEG C of drying, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
（3）By above-mentioned steps（1）~（2）The fine powder obtaining puts into mixing in container, and extraction is ground into powder, obtains the fine powder of 200 mesh,
Standby.
5. as described in a kind of any one as Claims 1 to 4, treat the preparation method of the Chinese and Western medicine compound preparation of hemorrhage of digestive tract, its
It is characterised by：Extraction process step including following traditional Chinese medicine ingredients：
（1）Bigleafbeautyberry root or leaf, baccate sedge herb, New Zealand spinach and White Chloe are put in container, adds the distilled water of 5～8 times amount, heating boils 2
～3 hours, extract, filter, obtain filtrate, heating is concentrated into pasty state, put into after 70 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains
Cross the fine powder of 160 mesh, standby；
（2）Clustered knotweed herb, nephelium lappaceum, broadbean pericarp and buckwheat are put in container, adds the distilled water of 3～6 times amount, heating boils 1
～2 hours, extract, filter, obtain filtrate, standby；
（3）Mandarin orange leaf, climbing violet herb and chicken gizzard are dissipated and cleans, chopping, put in container, twist juice, filter impurity, stay juice standby；
（4）Honey raisin tree seven is cleaned, immersion 3 times amount 60% alcohol solution dipping 1～2 hour, heating extraction 3 hours, reclaims second
Alcohol, filtration, obtain filtrate, standby；
（5）Yunnan pleione tuber is put in container, carries out pulverization process, grind into powder, obtained the fine powder of 180 mesh, standby；
（6）By above-mentioned steps（1）~（5）The fine powder that obtains, filtrate and carry out juice mixing, after stirring and dissolving is uniform, heating is dense
It is reduced to pasty state, put into after 60 DEG C of baking oven is dried and cool down, extraction is ground into powder, obtains the fine powder of 200 mesh, standby.
6. treat the preparation method of the Chinese and Western medicine compound preparation of hemorrhage of digestive tract according to claim 4 or claim 5, its
It is characterised by：Described Western medicine fine powder and traditional Chinese medicine fine powder are mixed, after stirring and dissolving is uniform, extracts and make tablet, obtain final product institute
The Chinese and Western medicine compound preparation of the treatment hemorrhage of digestive tract stated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610924060.1A CN106421600A (en) | 2016-10-24 | 2016-10-24 | Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610924060.1A CN106421600A (en) | 2016-10-24 | 2016-10-24 | Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106421600A true CN106421600A (en) | 2017-02-22 |
Family
ID=58177112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610924060.1A Pending CN106421600A (en) | 2016-10-24 | 2016-10-24 | Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106421600A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020014726A1 (en) * | 2018-07-20 | 2020-01-23 | Xenexus Pharmaceuticals Pty. Ltd. | Treatment for liver regeneration |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461917A (en) * | 2007-12-19 | 2009-06-24 | 丁月芳 | Chinese medicine for treating hemorrhage of upper digestive tract |
| CN105031388A (en) * | 2015-09-15 | 2015-11-11 | 徐玉田 | Medicine for treating alimentary tract hemorrhage and preparing method |
-
2016
- 2016-10-24 CN CN201610924060.1A patent/CN106421600A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461917A (en) * | 2007-12-19 | 2009-06-24 | 丁月芳 | Chinese medicine for treating hemorrhage of upper digestive tract |
| CN105031388A (en) * | 2015-09-15 | 2015-11-11 | 徐玉田 | Medicine for treating alimentary tract hemorrhage and preparing method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020014726A1 (en) * | 2018-07-20 | 2020-01-23 | Xenexus Pharmaceuticals Pty. Ltd. | Treatment for liver regeneration |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102716383A (en) | Traditional Chinese medicine composition for treating Crohn's disease | |
| CN102078549B (en) | Traditional Chinese medicine for treating oxyuriasis | |
| CN104288745A (en) | Traditional Chinese medicine for treating CG (Chronic Gastritis) | |
| CN103272019B (en) | Traditional Chinese medicinal composition for treating wind-heat and intestine-dryness type haememorrhoids | |
| CN106038965A (en) | Traditional Chinese medicinal composition for treating throat diseases | |
| CN106421600A (en) | Chinese-Western medicine compound preparation for treating alimentary tract hemorrhage and preparation method | |
| CN107854613A (en) | A kind of pill medicine and preparation method that can effectively treat epigastric pain | |
| CN104161926A (en) | Orally-taken drug for treating esophagus cancer and preparation method thereof | |
| CN109966442B (en) | Oral and external traditional Chinese medicine composition for treating ulcerative colitis and preparation method thereof | |
| CN103893603B (en) | The medicine of a kind of therapeutic radiation rectitis and preparation method | |
| CN103520550B (en) | Traditional Chinese medicine for treating external cold internal rheum type chronic bronchitis and preparation method thereof | |
| CN103877384B (en) | A kind of Chinese medicine preparation and preparation method who treats the carcinoma of the rectum | |
| CN103860682B (en) | One treats phthisical Chinese medicine preparation and preparation method | |
| CN105079686A (en) | Traditional Chinese medicine preparation for treating perianal and perirectal abscesses | |
| CN104815151A (en) | Traditional Chinese medicine for treating warm-dryness lung injury type cough | |
| CN104800675A (en) | Medicament for treating active ulcerative colitis | |
| CN107913402A (en) | A kind of combination of Chinese tradiational and Western medicine medicine for treating atrophic gastritis and preparation method | |
| CN103989836A (en) | Traditional Chinese medicine preparation for treating appendicitis and preparation method thereof | |
| CN103285181B (en) | Traditional Chinese medicine composition for treating qi-stagnation and blood stasis type haemorrhoids | |
| CN105395879A (en) | Traditional Chinese medicine used for treating senile chronic bronchitis | |
| CN104491276A (en) | Traditional Chinese medicine preparation for treating tinnitus and preparation method thereof | |
| CN103638368B (en) | A kind of Chinese medicine composition for the treatment of phlegm-damp type infantile bronchitis | |
| CN104815162B (en) | A kind of Chinese medicine composition treating pulmonary tuberculosis spitting of blood | |
| CN103735847A (en) | Drug for treating eczema and preparation method thereof | |
| CN117883536A (en) | Traditional Chinese medicine composition for treating intestinal inflammation and cancer transformation diseases and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170222 |
|
| WD01 | Invention patent application deemed withdrawn after publication |