CN111358882A - Traditional Chinese medicine composition for treating gouty arthritis, preparation method, preparation and application - Google Patents

Traditional Chinese medicine composition for treating gouty arthritis, preparation method, preparation and application Download PDF

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CN111358882A
CN111358882A CN202010376008.3A CN202010376008A CN111358882A CN 111358882 A CN111358882 A CN 111358882A CN 202010376008 A CN202010376008 A CN 202010376008A CN 111358882 A CN111358882 A CN 111358882A
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袁晓明
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Abstract

The invention relates to the technical field of traditional Chinese medicine compositions and preparation methods, in particular to a traditional Chinese medicine composition for treating gouty arthritis, which comprises the following components: herba Hedyotidis Diffusae, Scorpio, herba Verbenae, fructus Lipuidambaris, semen Vaccariae preparata, semen plantaginis preparata, rhizoma Dioscoreae Septemlobae, herba Lysimachiae Christinae, Prunellae Spica, vinegar carapax et Plastrum Testudinis, ramulus Mori, radix Aconiti Kusnezoffii Preparata, spora Lygodii, vinegar endothelium corneum Gigeriae Galli, Siegesbeckiae herba, rhizoma Smilacis Glabrae, and radix Clematidis. The traditional Chinese medicine composition is used as a medicinal effective component to prepare a corresponding traditional Chinese medicine preparation. The application of the traditional Chinese medicine composition in treating gout. The invention solves the problem of great side effect of traditional Chinese and western medicines in the prior art, and the medicinal composition has the effects of tonifying spleen and removing dampness, inducing diuresis to reduce edema, dispelling wind and activating collaterals, promoting blood circulation to remove blood stasis, regulating qi to alleviate pain, dredging channels and collaterals, relaxing muscles and tendons and removing paralysis through the synergistic effect of the medicinal effects, thereby promoting the excretion of damp turbidity, dissolving stasis, promoting the aging to cause novelty, enhancing the curative effect, obviously improving the symptoms and reducing the concentration of blood uric acid, and achieving the aim of effectively treating gout.

Description

Traditional Chinese medicine composition for treating gouty arthritis, preparation method, preparation and application
Technical Field
The invention relates to the technical field of traditional Chinese medicine compositions and preparation methods, in particular to a traditional Chinese medicine composition for treating gouty arthritis, a preparation method, a preparation and application.
Background
The prevalence rate of gouty arthritis diseases is very high at present, many patients are full of the diseases, and acute gouty arthritis belongs to one of the diseases, also called hyperuricemia and arthritis. Gouty arthritis is the metabolic disorder of purine substances in human bodies, the synthesis of uric acid is increased or the excretion of uric acid is reduced, hyperuricemia in the bodies is caused, when the concentration of blood uric acid is too high, uric acid is deposited in joint capsules, bursa, cartilage, bone and other tissues in the form of sodium salt, and foreign body inflammatory reaction of local tissues is caused for a long time, namely the gouty arthritis. Uric acid is a final product of purine metabolism, is a waste product generated in a body, and indicates that gout is dangerous, excessive improper diet (such as drinking) can cause high uric acid for patients with poor liver and kidney functions, mild higher uric acid does not have special uncomfortable symptoms, acute onset is converted into chronic arthritis, the average period is about 11 years, and the joints have rigid deformity and limited movement. Once gout stones are formed and deposited at joints and the like in a body, the quality of life and the body is reduced, if the gout arthritis is prevented and treated improperly, not only a patient feels pain during acute attack, but also serious consequences such as joint deformity, kidney stones, renal function damage and the like are easily caused, and gout patients are often accompanied by the tendency of obesity, hyperlipidemia, hyperglycemia and hypertension, so that the life quality of the patients is seriously influenced.
Gout taught by modern medicine is also equivalent to symptoms of pain arthralgia, calendar festival and the like in traditional Chinese medicine, and discussion about gouty arthritis is recorded in traditional Chinese medicine. In the period of Zhuyuan, the name of gout is proposed for the first time by Zhu Danxi, and the statement of Danxi Xin Fa: "gout patients, swelling and pain of the limbs and joints". In the Ming Dynasty Zhang Jingyue (Jingyue quan Shu. beriberi), it is considered that the exterior is yin cold and dampness, and the damp pathogen attacks the skin, flesh, tendons and vessels of the human body; the interior meridian is too fatty and sweet, and dampness stagnates in the lower energizer; cold and dampness combine to transform into heat, which stays in … … red swelling and tidal fever of the affected part of skin, and bone erosion occurs after a long time. Qing, linpei qin (presidential treatment of diseases) sanction: gout and arthralgia, which are caused by wind-cold-dampness stagnation in the yin system at the beginning of … …, and pain caused by heat transformation even at night. "it can be seen that doctors of all ages have a deep understanding of gout, which is mainly caused by weakness of vital qi in the body, wind-cold-dampness arthralgia, phlegm stagnation and obstruction of collaterals for a long time.
At present, western medicines are usually used for inhibiting the generation of uric acid by allopurinol, promoting the excretion of uric acid by probenecid and relieving pain by colchicine, but the medicines are easy to cause gastrointestinal reactions such as nausea, vomiting, diarrhea and the like or cause the reduction of leucocytes in the process of taking the medicines, and have the inhibiting effect on bone marrow and damage to the functions of liver and kidney, and after allopurin is taken, the medicines can cause fever, abdominal pain, diarrhea, allergic rash, leukopenia and thrombocytopenia and even damage to the functions of liver and kidney. Therefore, the toxic and side effects of the treatment of the western medicines are very large, and along with the continuation of the medicine taking time, the side effects and fear psychology of the patients to the medicines are gradually increased, so that the serious influence is caused on the bodies and psychology of the patients, and the families of the patients also bear great economic pressure and the risks of morbidity and aggravation of the patients at any time.
Disclosure of Invention
In view of the disadvantages of the prior art, the present invention aims to provide a Chinese medicinal composition for treating gouty arthritis, which is used for solving the problem of great side effects of traditional Chinese medicines and western medicines in the prior art, and simultaneously, the present invention also provides a preparation method of the Chinese medicinal composition for treating gouty arthritis; the invention also provides a Chinese medicinal preparation of the Chinese medicinal composition for treating gouty arthritis; in addition, the invention also provides a new application of the traditional Chinese medicine composition for treating gouty arthritis. According to the invention, through the combination of oldenlandia diffusa, scorpion, verbena, beautiful sweetgum fruit, stir-fried cowherb seed, salted plantain seed, yam rhizome, longhairy antenoron herb, common selfheal fruit-spike, vinegar tortoise shell, mulberry twig, prepared kusnezoff monkshood root, Japanese climbing fern spore, vinegar chicken gizzard-membrane, herba siegesbeckiae, glabrous greenbrier rhizome and clematis root, the medicinal effects generate synergistic effects, so that the medicinal composition has the effects of tonifying spleen, removing dampness, inducing diuresis, reducing swelling, dispelling wind, activating collaterals, promoting blood circulation, removing blood stasis, regulating qi, relieving pain, promoting meridians, relaxing tendons and removing arthralgia, thereby promoting damp turbidity excretion, dissolving stasis, promoting aging, enhancing curative effect, obviously improving symptoms and reducing blood uric acid concentration, and further achieving the purpose of effectively treating gout (gouty arthritis).
In order to attain the above and other related objects,
the invention provides a traditional Chinese medicine composition for treating gouty arthritis, which comprises the following components in parts by weight: 5-20 parts of spreading hedyotis herb, 1-4 parts of scorpion, 6-12 parts of verbena, 6-12 parts of beautiful sweetgum fruit, 6-12 parts of fried cowherb seed, 5-12 parts of semen plantaginis, 5-20 parts of yam rhizome, 7-13 parts of longhairy antenoron herb, 5-20 parts of selfheal, 5-12 parts of vinegar tortoise shell, 5-15 parts of mulberry twig, 1-4 parts of prepared kusnezoff monkshood root, 5-20 parts of Japanese climbing fern spore, 5-20 parts of vinegar chicken gizzard-membrane, 5-20 parts of siegesbeckia herb, 5-20 parts of glabrous greenbrier rhizome and 5-20 parts of clematis root.
The traditional Chinese medicine composition is prepared from oldenlandia diffusa, scorpion, verbena, beautiful sweetgum fruit, stir-fried cowherb seed, salted plantain seed, yam rhizome, longhairy antenoron herb, common selfheal fruit-spike, vinegar tortoise shell, mulberry twig, prepared kusnezoff monkshood root, lygodium japonicum, vinegar chicken gizzard-membrane, herba siegesbeckiae, glabrous greenbrier rhizome and clematis root, so that the medicinal effects generate synergistic action, and the medicinal composition has the effects of tonifying spleen and removing dampness, inducing diuresis and reducing swelling, dispelling wind and activating collaterals, promoting blood circulation and removing blood stasis, regulating qi and relieving pain, promoting menstruation and relaxing tendons and removing arthralgia, thereby promoting damp turbidity excretion, dissolving stasis, promoting regeneration, enhancing curative effect, obviously improving symptoms and reducing blood uric acid concentration, and further achieving the purpose of effectively treating gout (gouty.
Herba Hedyotidis Diffusae, herba Verbenae, herba Lysimachiae Christinae, Prunellae Spica, and Siegesbeckiae herba etc. have effects of promoting diuresis, detumescence, promoting blood circulation and removing blood stasis; selecting root medicines such as clematis root, mulberry twig, beautiful sweetgum fruit, yam rhizome and the like, and having the effects of dispelling wind, dredging collaterals, promoting diuresis and removing dampness; adopts climbing fern spore and other medicines, and has the effects of dispelling wind and relieving pain, promoting urination, and eliminating damp arthralgia; rhizoma smilacis glabrae is selected, and has the effects of tonifying spleen, removing dampness, detoxifying and easing joint movement; the vinegar tortoise shells are selected, and have the effects of guiding yang qi to enter, dredging yin qi to ascend, dredging yin and yang blood vessels, relaxing muscles and tendons and removing paralysis; the prepared kusnezoff monkshood root is selected, so that the effects of dispelling wind and removing dampness, warming channels and relieving pain are achieved, and the problem that the traditional medicines are too cold can be balanced; the scorpion is selected, and has the effects of dredging collaterals and relieving pain, and treating rheumatism stubborn paralysis; the vinegar-processed chicken gizzard membrane is selected, so that the effects of removing food retention, removing stones, reducing phlegm, regulating qi and promoting diuresis are achieved, and the risk of tophus (gout nodules) can be effectively reduced. The traditional Chinese medicine composition has the effects of tonifying spleen and removing dampness, inducing diuresis and reducing edema, dispelling wind and activating collaterals, promoting blood circulation and removing blood stasis, regulating qi and relieving pain, dredging channels and collaterals, relaxing muscles and tendons and removing arthralgia, and has definite curative effect and low price. The traditional Chinese medicine composition can relieve pain of patients caused by gout and reduce harm of western medicines to the bodies of the patients; and the cost of the traditional Chinese medicine is reduced, thereby reducing the burden of families.
The traditional Chinese medicine composition has clear treatment rules and reasonable compatibility, and the traditional Chinese medicines in the formula have synergistic effect, and have the effects of tonifying spleen and removing dampness, promoting diuresis and reducing swelling, dispelling wind and activating collaterals, promoting blood circulation and removing blood stasis, regulating qi and relieving pain, dredging channels and collaterals, and relaxing muscles and tendons and removing paralysis. The traditional Chinese medicine composition promotes in vivo uric acid excretion, reduces blood uric acid, regulates purine metabolic disorder, and enables a patient to comprehensively recover the autonomous metabolic function while reducing blood uric acid, so that the effect of treating gout and complications caused by gout of the patient by correcting origin is achieved, the traditional Chinese medicine composition has the advantages of good curative effect, quick response and capability of treating both symptoms and root causes, the pain of many patients is relieved through years of clinical application, and the harm of western medicines to the body of the patient is reduced.
Further, the traditional Chinese medicine composition comprises the following components in parts by weight: 9-15 parts of spreading hedyotis herb, 1.5-3 parts of scorpion, 8-10 parts of verbena, 8-10 parts of beautiful sweetgum fruit, 8-10 parts of fried cowherb seed, 7-10 parts of salted plantain seed, 8-15 parts of yam rhizome, 10-15 parts of longhairy antenoron herb, 10-15 parts of selfheal spike, 7-10 parts of vinegar tortoise shell, 8-12 parts of mulberry twig, 1.5-3 parts of prepared kusnezoff monkshood root, 10-15 parts of climbing fern spore, 10-15 parts of vinegar chicken gizzard-membrane, 10-15 parts of herba siegesbeckiae, 10-15 parts of glabrous greenbrier rhizome and 10-15 parts of clematis root.
Herba Hedyotidis Diffusae: clearing heat, promoting diuresis, treating stranguria, relieving fatigue, removing toxic substances, removing blood stasis, resisting tumor, promoting urination, relieving swelling, diminishing inflammation and relieving pain. The recipe is mainly designed to have the effects of promoting diuresis, inducing diuresis, relieving swelling and dissipating blood stasis.
Scorpion: wind-extinguishing, spasm-relieving, collateral-dredging, pain-relieving, toxic-counteracting and nodulation-dissipating, and can be used for stirring of liver-wind, spasm and convulsion, infantile convulsion and apoplexy
Figure BDA0002480071690000031
Hemiplegia, tetanus, stubborn rheumatism, migraine, sore and ulcer, scrofula. The recipe is mainly used for dredging collaterals, alleviating pain, counteracting toxic pathogen and dissipating nodulation, and is good at treating stubborn arthralgia due to wind-damp.
Verbena: clearing away heat and toxic material, promoting blood circulation to disperse blood clots, inducing diuresis to alleviate edema. It can be used for treating fever, jaundice due to damp-heat pathogen, edema, dysentery, malaria, diphtheria, pharyngitis, gonorrhea, amenorrhea, abdominal mass, carbuncle, sore, and ulcerative gingivitis. The recipe is mainly designed to take the effects of promoting blood circulation, removing blood stasis, inducing diuresis and relieving edema.
The road is through: dispel wind, dredge collaterals, induce diuresis and remove dampness. It is indicated for arthralgia of limbs, spasm of hand and foot, stomachache, edema, distention, amenorrhea, oliguria, carbuncle, cellulitis, hemorrhoid, scabies, tinea and eczema. The recipe is mainly designed to have the effects of removing dampness and swelling, dispelling wind and activating collaterals, dredging channels and collaterals, relaxing tendons and removing paralysis.
Frying the cowherb seeds: has effects of promoting blood circulation, dredging channels, promoting lactation, relieving swelling, inducing diuresis, and treating stranguria. Can be used for treating amenorrhea, dysmenorrhea, galactorrhea, acute mastitis, and stranguria with pain. The book of Benjing says that the jin sores stop bleeding, relieve pain and spur, remove wind-arthralgia and internal cold, lighten the body, resist aging and prolong life. The recipe is mainly designed to dispel wind, relieve pain, activate blood and dredge meridians.
Salted plantain seed: induce diuresis, clear heat, improve eyesight, dispel phlegm. It is indicated for dysuria, stranguria with turbid urine, leukorrhagia, hematuria, summer-heat dampness, dysentery, cough with excessive phlegm, damp arthralgia, conjunctival congestion and nebula. The book Jing: it can promote urination, relieve pain, promote urination and eliminate damp arthralgia. The recipe is mainly designed to relieve pain, induce diuresis and remove damp arthralgia.
Rhizoma Dioscoreae Septemlobae: it is mainly used for dispelling pathogenic wind, removing dampness by diuresis, and treating rheumatism, pain of waist and knee, dysuresia, stranguria with turbid urine, spermatorrhea, damp-heat sore.
Herba Lysimachiae Christinae: induce diuresis to alleviate jaundice, induce diuresis to treat stranguria, remove toxicity and relieve swelling. Can be used for treating damp-heat jaundice, gallbladder distention, hypochondriac pain, stranguria with stone, stranguria with heat, difficulty and pain in urination, carbuncle, furuncle, and snake and insect bite. In the Chiense on Sichuan Chinese herbs (Yan Zhi): for rheumatic numbness, arthralgia and myalgia, jaundice and pulmonary abscess.
Selfheal: can be used for treating conjunctival congestion, swelling and pain, eye bead nyctalgia, headache, giddiness, scrofula, goiter, mammary abscess, mammary nodules, and breast pain. The stubborn stone changes from Wen Yuan (meeting original) into bitter, pungent and warm, so that bitter can purge and descend, pungent can dredge and warm can circulate, and is good at dispersing stagnation of liver-gallbladder fire and suffocation, thereby smoothing the circulation of qi and blood. It is specialized in treating wind-cold arthralgia due to accumulation of phlegm and accumulation of qi.
Vinegar tortoise shell: can be used for treating hectic fever due to yin deficiency, hectic fever, night sweat, dizziness, internal stirring of deficient wind, flaccidity of bones and muscles, heart deficiency, amnesia, metrorrhagia, and menorrhagia. Water treated by Gui Jia from Ben Cao Si Bian Lu, non-flowing water; the fire treated is not a rampant fire. Gui Jia can induce yang-qi to enter downward and unblock yin-qi to ascend upward. The recipe is designed to treat syndrome of obstruction of tendons and bones, mainly because it can activate yin, yang, blood and vessels.
Mulberry twig: used for rheumatic arthralgia, soreness and numbness of the shoulder, arm and joint, this draft Bingjing: treating itching and dryness of body, beriberi and spasm of limbs.
Preparing kusnezoff monkshood root: radix Aconiti Kusnezoffii has strong drug action, and has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain, and can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, and cold hernia.
Climbing fern spore: can be used for treating pyretic stranguria, urolithic stranguria, bloody stranguria, chylous stranguria, and urethral astringency and pain. According to the fine mesh of the rare herb when plum is used, the seed is sweet, cold and nontoxic. The main treatment is as follows: promoting small intestine, treating typhoid fever and mania, treating damp-heat toxic swelling, treating stranguria with heat in urine, stranguria with chyluria, stranguria with blood, stranguria with stone, and relieving heat and toxic gas. It is indicated for pain of tendons and bones in Sichuan Zhi (records of Chinese materia Medica in Sichuan).
Vinegar chicken's gizzard-membrane: strengthening the stomach to promote digestion, arresting seminal emission and relieving enuresis, and treating stranguria and removing calculus. It is indicated for indigestion, vomiting, dysentery, infantile malnutrition, enuresis and seminal emission. The "Renzai of materia Medica": to resolve phlegm, regulate qi and remove dampness. The recipe is mainly designed to take the effects of resolving food stagnation, removing calculi, reducing phlegm, regulating qi and promoting diuresis.
Herba siegesbeckiae: has the effects of dispelling wind-damp, dredging channels and collaterals, and clearing away heat and toxic materials. Can be used for treating rheumatalgia, tendons and bones disorder, weakness of waist and knees, hemiplegia, hypertension, malaria, jaundice, carbuncle, sore, rubella, eczema, insect bite, and animal bite.
Glabrous greenbrier rhizome: it has effects in eliminating dampness, removing toxic materials, and relieving joint pain, and can be used for treating damp-heat stranguria with turbid pathogen, leukorrhagia, carbuncle, lymphoid tuberculosis, scabies, tinea, and spasm of limbs and arthralgia and myalgia due to syphilis and hydrargyrism.
Clematis root: dispelling wind-damp, dredging channels and collaterals, eliminating phlegm and saliva, dispelling nodule, treating gout, stubborn arthralgia, psychroalgia of waist and knee, beriberi, malaria, abdominal mass, tetanus, tonsillitis, and bone sticking throat.
Further preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 15 parts of spreading hedyotis herb, 3 parts of scorpion, 10 parts of verbena, 10 parts of beautiful sweetgum fruit, 10 parts of fried cowherb seed, 10 parts of salted plantain seed, 15 parts of long pepper, 15 parts of longhairy antenoron herb, 15 parts of common selfheal fruit-spike, 10 parts of vinegar tortoise shell, 12 parts of mulberry twig, 3 parts of prepared kusnezoff monkshood root, 15 parts of Japanese climbing fern spore, 15 parts of vinegar chicken's gizzard-membrane, 15 parts of siegesbeckia herb, 15 parts of glabrous greenbrier rhizome and 15 parts of clematis root.
The traditional Chinese medicine composition has clear treatment rules and reasonable compatibility, and the traditional Chinese medicines in the formula have synergistic effect, and have the effects of tonifying spleen and removing dampness, promoting diuresis and reducing swelling, dispelling wind and activating collaterals, promoting blood circulation and removing blood stasis, regulating qi and relieving pain, dredging channels and collaterals, and relaxing muscles and tendons and removing paralysis. The traditional Chinese medicine composition with the proportion can achieve the effects of strengthening body resistance and clearing away sources for treating the gout disease of patients and complications caused by the gout, has good curative effect and quick response, and can achieve the effect of treating both symptoms and root causes.
Further preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 12 parts of oldenlandia diffusa, 2 parts of scorpion, 8 parts of verbena, 8 parts of beautiful sweetgum fruit, 8 parts of fried cowherb seed, 8 parts of salted plantain seed, 13 parts of long pepper, 13 parts of longhairy antenoron herb, 13 parts of selfheal, 8 parts of vinegar tortoise shell, 10 parts of mulberry twig, 2 parts of prepared kusnezoff monkshood root, 13 parts of lygodium japonicum, 13 parts of vinegar chicken's gizzard-membrane, 13 parts of siegesbeckia herb, 13 parts of glabrous greenbrier rhizome and 13 parts of clematis root.
The traditional Chinese medicine composition has the synergistic effect of the effects of all the medicines, so that the medicine composition has the effects of tonifying spleen and removing dampness, promoting urination and reducing swelling, dispelling wind and activating collaterals, promoting blood circulation and removing blood stasis, regulating qi to alleviate pain, promoting meridian circulation and relaxing tendons and removing paralysis, thereby promoting the excretion of damp turbidity, dissolving stasis, promoting the growth of new organs caused by aging, enhancing the curative effect, obviously improving symptoms and reducing the concentration of blood uric acid, and further achieving the aim of effectively treating gout.
In a second aspect of the present invention, a preparation method of a traditional Chinese medicine composition for treating gouty arthritis is provided, which comprises: adding the herba Hedyotidis Diffusae, Scorpio, herba Verbenae, fructus Lipuidambaris, parched semen Vaccariae, Sal semen plantaginis, rhizoma Dioscoreae Septemlobae, herba Lysimachiae Christinae, Prunellae Spica, vinegar carapax et Plastrum Testudinis, ramulus Mori, radix Aconiti Kusnezoffii Preparata, spora Lygodii, vinegar endothelium corneum Gigeriae Galli, Siegesbeckiae herba, rhizoma Smilacis Glabrae and radix Clematidis into a pulverizer according to the above ratio, pulverizing, and sieving.
Herba Hedyotidis Diffusae, Scorpio, herba Verbenae, fructus Lipuidambaris, semen Vaccariae preparata, semen plantaginis preparata, rhizoma Dioscoreae Septemlobae, herba Lysimachiae Christinae, Prunellae Spica, vinegar carapax et Plastrum Testudinis, ramulus Mori, radix Aconiti Kusnezoffii Preparata, spora Lygodii, vinegar endothelium corneum Gigeriae Galli, Siegesbeckiae herba, rhizoma Smilacis Glabrae and radix Clematidis by adding corresponding Chinese medicinal decoction pieces into a pulverizer, and making into the final product. The traditional Chinese medicine composition powder prepared by the preparation method has the advantages of definite curative effect on gout, low price, small side effect and short cure time. The Chinese medicinal composition powder can be used for decocting, making into pill or directly hot compressing; wherein the decoction is safe to take, convenient to carry and has small side effect; the pills are prepared to be convenient to take; the direct hot compress on arthritis also has certain curative effect.
In a third aspect of the present invention, a preparation method of a traditional Chinese medicine composition for treating gouty arthritis is provided, which comprises: adding the herba Hedyotidis Diffusae, Scorpio, herba Verbenae, fructus Lipuidambaris, parched semen Vaccariae, Sal semen plantaginis, rhizoma Dioscoreae Septemlobae, herba Lysimachiae Christinae, Prunellae Spica, vinegar carapax et Plastrum Testudinis, ramulus Mori, radix Aconiti Kusnezoffii Preparata, spora Lygodii, vinegar endothelium corneum Gigeriae Galli, Siegesbeckiae herba, rhizoma Smilacis Glabrae and radix Clematidis into a decocting device according to the above ratio, decocting, and concentrating.
Herba Hedyotidis Diffusae, Scorpio, herba Verbenae, fructus Lipuidambaris, semen Vaccariae preparata, semen plantaginis preparata, rhizoma Dioscoreae Septemlobae, herba Lysimachiae Christinae, Prunellae Spica, vinegar carapax et Plastrum Testudinis, ramulus Mori, radix Aconiti Kusnezoffii Preparata, spora Lygodii, vinegar endothelium corneum Gigeriae Galli, Siegesbeckiae herba, rhizoma Smilacis Glabrae and radix Clematidis by adding corresponding Chinese medicinal decoction pieces into decocting device, decocting, and concentrating and drying to obtain medicinal liquid for direct administration or concentrating and drying to obtain granule for direct administration. The traditional Chinese medicine composition has the advantages of definite curative effect on gout, low price, small side effect and short cure time.
The fourth aspect of the invention provides a traditional Chinese medicine preparation containing a traditional Chinese medicine composition for treating gouty arthritis, and the traditional Chinese medicine preparation consists of the traditional Chinese medicine composition and a pharmaceutically acceptable carrier and/or excipient. The Chinese medicine preparation is any clinically acceptable dosage form, preferably tablet, capsule, granule, oral liquid, dripping pill, etc.
In clinical medical practice for many years, according to the development rule of gout diseases and the compatibility principle of traditional Chinese medicines, and through a large number of clinical verifications, the prescription of a traditional Chinese medicine composition for treating gouty arthritis is explored and summarized, spreading hedyotis herb, scorpion, verbena, beautiful sweetgum fruit, stir-fried cowherb seed, salted plantain seed, yam rhizome, longhairy antenoron herb, common selfheal fruit-spike, vinegar tortoise shell, mulberry twig, prepared kusnezoff monkshood root, Japanese climbing fern spore, vinegar chicken gizzard-membrane, herba siegesbeckiae, glabrous greenbrier rhizome, clematis root and the like are selected, the medicines are selected, one dose is taken 3 times a day, and the effects of the medicines generate synergistic action through the combination of the medicines, so that the traditional Chinese medicine has the effects of strengthening spleen, removing dampness, inducing diuresis, reducing edema, dispelling wind, activating collaterals, promoting blood circulation, removing blood stasis, regulating qi, relieving pain, promoting meridians, relaxing muscles and tendons, removing arthralgia, thereby promoting the excretion of damp turbidity, the purpose of effectively treating gout is achieved.
In order to ensure the quality of the medicine, the traditional Chinese medicine composition of the invention is preferably a Beijing kang rentang traditional Chinese medicine full-ingredient granular preparation, the preparation form is derived from traditional Chinese medicine decoction pieces, the characteristics of the traditional Chinese medicine decoction pieces are kept on a plurality of characteristics, the traditional Chinese medicine composition is a deep processing product of a decoction-like traditional Chinese medicine decoction piece, the traditional Chinese medicine decoction pieces in the original state of the bark shape of grass roots are converted into medicines by water extraction, and the traditional Chinese medicine composition can be used as a composing prescription raw material of various traditional. The granular compound preparation prepared by adopting the granular preparation combination is characterized in that: basically reserves the components of the original traditional Chinese medicine, avoids the need of decocting the special medicine first and then taking the medicine down, and adopts a small package mode, so the use and the carrying are very convenient, and the curative effect is the same as that of the decocted traditional Chinese medicine.
Modern life rhythm is fast, and traditional chinese medicine's decocte need spend a lot of time, and it is also inconvenient to take, also portable, adopts granule, and the preparation is simple and convenient, takes conveniently, avoids the decoct, and portable is safe high-efficient, and innoxic side effect, cure time are short. For the selected toxic and side effect medicine such as kusnezoff monkshood root, because the granules are processed in advance, the granules do not have toxic and side effects any more and do not have the trouble of boiling in advance. The traditional Chinese medicine composition can relieve pain of patients caused by gout, reduce harm of western medicines to the bodies of the patients, and simultaneously reduce family burden.
The granular preparation is better applied in domestic hospitals at present, more manufacturers are available for producing the granular preparation at present, the selected product is not a full-ingredient granular preparation, the manufacturing process of the full-ingredient granular preparation is more complex, the required conditions are high, the medicine purity is high, and the curative effect is guaranteed. The Kanrotang company is the earliest manufacturer for developing full-ingredient granular preparations, and the quality of the full-ingredient granular preparation of the traditional Chinese medicine is high, so the preparation of the Kanrotang company is selected as the formula. The technical scheme adopts all the components of the traditional Chinese medicine particles of the kang rentang, the prescription and the dosage range are as follows, the dosage of the prescription is based on the dosage of adults, and the dosage of children is reduced according to the standard.
Selecting full-ingredient granular preparation (Beijing kang rentang Chinese medicinal full-ingredient granular preparation) corresponding to each component to prepare granular compound preparation, and taking one dose every day for 3 times every day. The preparation process specifically comprises the following steps: the method comprises the following steps: checking the dosage of each medicine and the required treatment course time; step two: the medicine is prepared according to the proportion of the formula of each medicine, and the equipment is selected as follows: traditional chinese medicine dispensing equipment MD6120, manufacturer: beijing and Likang Yuan medical science and technology Co., Ltd (currently, more than two levels of hospitals and some traditional Chinese medicine clinics in China use or use similar equipment); step three: checking the number of the packed medicine bags and checking whether the medicine bags are intact, preferably, the name, age and administration method of the patient are indicated on each small bag; step four: the corresponding medicine can be produced by traditional Chinese medicine dispensing equipment.
In a fourth aspect of the invention, an application of a traditional Chinese medicine composition for treating gouty arthritis in treating gout is provided. The traditional Chinese medicine composition has clear treatment rules and reasonable compatibility, and the traditional Chinese medicines in the formula have synergistic effect, and have the effects of tonifying spleen and removing dampness, promoting diuresis and reducing swelling, dispelling wind and activating collaterals, promoting blood circulation and removing blood stasis, regulating qi and relieving pain, dredging channels and collaterals, and relaxing muscles and tendons and removing paralysis. The traditional Chinese medicine composition promotes in vivo uric acid excretion, reduces blood uric acid, regulates purine metabolic disorder, and enables a patient to comprehensively recover the autonomous metabolic function while reducing blood uric acid, so that the effect of treating gout and complications caused by gout of the patient by correcting origin is achieved, the traditional Chinese medicine composition has the advantages of good curative effect, quick response and capability of treating both symptoms and root causes, the pain of many patients is relieved through years of clinical application, and the harm of western medicines to the body of the patient is reduced.
Further, the gout is acute gouty arthritis or chronic gouty arthritis. The traditional Chinese medicine composition promotes in vivo uric acid excretion, reduces blood uric acid, regulates purine metabolic disorder, and enables a patient to comprehensively recover the autonomous metabolic function while reducing blood uric acid, so that the effect of treating complications caused by acute gouty arthritis or chronic gouty arthritis of the patient by correcting origin is achieved, the traditional Chinese medicine composition has good curative effect and quick response, the effect of treating both symptoms and root causes can be achieved, the pain of many patients is relieved through years of clinical application, and the harm of western medicines to the body of the patient is reduced.
As described above, the traditional Chinese medicine composition for treating gouty arthritis, the preparation method, the traditional Chinese medicine preparation and the application of the traditional Chinese medicine composition have the following beneficial effects: herba Hedyotidis Diffusae, herba Verbenae, herba Lysimachiae Christinae, Prunellae Spica, and Siegesbeckiae herba etc. have effects of promoting diuresis, detumescence, promoting blood circulation and removing blood stasis; selecting root medicines such as clematis root, mulberry twig, beautiful sweetgum fruit, yam rhizome and the like, and having the effects of dispelling wind, dredging collaterals, promoting diuresis and removing dampness; selecting the medicines of fried cowherb seed, plantain seed, lygodium japonicum and the like to dispel wind, and has the effects of relieving pain, promoting urination and removing damp arthralgia; rhizoma smilacis glabrae is selected, and has the effects of tonifying spleen, removing dampness, detoxifying and easing joint movement; selecting vinegar tortoise shell, and has effects of guiding yang qi downward, dredging yin qi upward, dredging yin and yang blood vessels, and blocking tendons and bones; the prepared kusnezoff monkshood root is selected, so that the effects of dispelling wind and removing dampness, warming channels and relieving pain are achieved, and the problem that the traditional medicines are too cold can be balanced; the scorpion is selected, and has the effects of dredging collaterals and relieving pain, and treating rheumatism stubborn paralysis; the vinegar-processed chicken gizzard membrane is selected, so that the effects of removing food retention, removing stones, reducing phlegm, regulating qi and promoting diuresis are achieved, and the risk of tophus (gout nodules) can be effectively reduced. The traditional Chinese medicine composition has the effects of tonifying spleen and removing dampness, inducing diuresis and reducing edema, dispelling wind and activating collaterals, promoting blood circulation and removing blood stasis, regulating qi and relieving pain, dredging channels and collaterals, relaxing muscles and tendons and removing arthralgia, and has definite curative effect and low price. The traditional Chinese medicine composition can relieve pain of patients caused by gout and reduce harm of western medicines to the bodies of the patients; and the cost of the traditional Chinese medicine is reduced, thereby reducing the burden of families. The traditional Chinese medicine composition has clear treatment rules and reasonable compatibility, and the traditional Chinese medicines in the formula have synergistic effect, and have the effects of tonifying spleen and removing dampness, promoting diuresis and reducing swelling, dispelling wind and activating collaterals, promoting blood circulation and removing blood stasis, regulating qi and relieving pain, dredging channels and collaterals, and relaxing muscles and tendons and removing paralysis. The traditional Chinese medicine composition promotes in vivo uric acid excretion, reduces blood uric acid, regulates purine metabolic disorder, and enables a patient to comprehensively recover the autonomous metabolic function while reducing blood uric acid, so that the effect of treating gout and complications caused by gout of the patient by correcting origin is achieved, the traditional Chinese medicine composition has the advantages of good curative effect, quick response and capability of treating both symptoms and root causes, the pain of many patients is relieved through years of clinical application, and the harm of western medicines to the body of the patient is reduced.
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.
Example 1
A traditional Chinese medicine composition for treating gouty arthritis comprises the following components in parts by weight: 5 parts of oldenlandia diffusa, 1 part of scorpion, 6 parts of verbena, 6 parts of beautiful sweetgum fruit, 6 parts of fried cowherb seed, 5 parts of salted plantain seed, 5 parts of long pepper, 7 parts of longhairy antenoron herb, 5 parts of selfheal, 5 parts of vinegar tortoise shell, 5 parts of mulberry twig, 1 part of prepared kusnezoff monkshood root, 5 parts of Japanese climbing fern spore, 5 parts of vinegar chicken gizzard membrane, 5 parts of siegesbeckia herb, 5 parts of glabrous greenbrier rhizome and 5 parts of clematis root.
Selecting full-ingredient granular preparation (Beijing kang rentang Chinese medicinal full-ingredient granular preparation) corresponding to each component to prepare granular compound preparation, and taking one dose every day for 3 times every day. The preparation process specifically comprises the following steps: the method comprises the following steps: checking the dosage of each medicine and the required treatment course time; step two: the medicine is prepared according to the proportion of the formula of each medicine, and the equipment is selected as follows: traditional chinese medicine dispensing equipment MD6120, manufacturer: beijing and Likang Yuan medical science and technology Co., Ltd (currently, more than two levels of hospitals and some traditional Chinese medicine clinics in China use or use similar equipment); step three: the corresponding Chinese medicine preparation can be produced by Chinese medicine dispensing equipment.
Example 2
A traditional Chinese medicine composition for treating gouty arthritis comprises the following components in parts by weight: 20 parts of oldenlandia diffusa, 4 parts of scorpion, 12 parts of verbena, 12 parts of beautiful sweetgum fruit, 12 parts of fried cowherb seed, 12 parts of salted plantain seed, 20 parts of long pepper, 13 parts of longhairy antenoron herb, 20 parts of selfheal, 12 parts of vinegar tortoise shell, 15 parts of mulberry twig, 4 parts of prepared kusnezoff monkshood root, 20 parts of Japanese climbing fern spore, 20 parts of vinegar chicken gizzard membrane, 20 parts of siegesbeckia herb, 20 parts of glabrous greenbrier rhizome and 20 parts of clematis root.
Selecting full-ingredient granular preparation (Beijing kang rentang Chinese medicinal full-ingredient granular preparation) corresponding to each component to prepare granular compound preparation, and taking one dose every day for 3 times every day. The preparation process specifically comprises the following steps: the method comprises the following steps: checking the dosage of each medicine and the required treatment course time; step two: the medicine is prepared according to the proportion of the formula of each medicine, and the equipment is selected as follows: traditional chinese medicine dispensing equipment MD6120, manufacturer: beijing and Likang Yuan medical science and technology Co., Ltd (currently, more than two levels of hospitals and some traditional Chinese medicine clinics in China use or use similar equipment); step three: the corresponding Chinese medicine preparation can be produced by Chinese medicine dispensing equipment.
Example 3
A traditional Chinese medicine composition for treating gouty arthritis comprises the following components in parts by weight: 9 parts of oldenlandia diffusa, 1.5 parts of scorpion, 8 parts of verbena, 8 parts of beautiful sweetgum fruit, 8 parts of fried cowherb seed, 7 parts of salted plantain seed, 8 parts of long pepper yam rhizome, 10 parts of longhairy antenoron herb, 10 parts of selfheal, 7 parts of vinegar tortoise shell, 8 parts of mulberry twig, 1.5 parts of prepared kusnezoff monkshood root, 10 parts of lygodium japonicum, 10 parts of vinegar chicken gizzard membrane, 10 parts of herba siegesbeckiae, 10 parts of glabrous greenbrier rhizome and 10 parts of clematis chinensis.
Selecting full-ingredient granular preparation (Beijing kang rentang Chinese medicinal full-ingredient granular preparation) corresponding to each component to prepare granular compound preparation, and taking one dose every day for 3 times every day. The preparation process specifically comprises the following steps: the method comprises the following steps: checking the dosage of each medicine and the required treatment course time; step two: the medicine is prepared according to the proportion of the formula of each medicine, and the equipment is selected as follows: traditional chinese medicine dispensing equipment MD6120, manufacturer: beijing and Likang Yuan medical science and technology Co., Ltd (currently, more than two levels of hospitals and some traditional Chinese medicine clinics in China use or use similar equipment); step three: the corresponding Chinese medicine preparation can be produced by Chinese medicine dispensing equipment.
Example 4
A traditional Chinese medicine composition for treating gouty arthritis comprises the following components in parts by weight: 15 parts of spreading hedyotis herb, 3 parts of scorpion, 10 parts of verbena, 10 parts of beautiful sweetgum fruit, 10 parts of fried cowherb seed, 10 parts of salted plantain seed, 15 parts of long pepper, 15 parts of longhairy antenoron herb, 15 parts of common selfheal fruit-spike, 10 parts of vinegar tortoise shell, 12 parts of mulberry twig, 3 parts of prepared kusnezoff monkshood root, 15 parts of Japanese climbing fern spore, 15 parts of vinegar chicken's gizzard-membrane, 15 parts of siegesbeckia herb, 15 parts of glabrous greenbrier rhizome and 15 parts of clematis root.
Selecting full-ingredient granular preparation (Beijing kang rentang Chinese medicinal full-ingredient granular preparation) corresponding to each component to prepare granular compound preparation, and taking one dose every day for 3 times every day. The preparation process specifically comprises the following steps: the method comprises the following steps: checking the dosage of each medicine and the required treatment course time; step two: the medicine is prepared according to the proportion of the formula of each medicine, and the equipment is selected as follows: traditional chinese medicine dispensing equipment MD6120, manufacturer: beijing and Likang Yuan medical science and technology Co., Ltd (currently, more than two levels of hospitals and some traditional Chinese medicine clinics in China use or use similar equipment); step three: the corresponding Chinese medicine preparation can be produced by Chinese medicine dispensing equipment.
Example 5
A traditional Chinese medicine composition for treating gouty arthritis comprises the following components in parts by weight: 12 parts of oldenlandia diffusa, 2 parts of scorpion, 8 parts of verbena, 8 parts of beautiful sweetgum fruit, 8 parts of fried cowherb seed, 8 parts of salted plantain seed, 13 parts of long pepper, 13 parts of longhairy antenoron herb, 13 parts of selfheal, 8 parts of vinegar tortoise shell, 10 parts of mulberry twig, 2 parts of prepared kusnezoff monkshood root, 13 parts of lygodium japonicum, 13 parts of vinegar chicken's gizzard-membrane, 13 parts of siegesbeckia herb, 13 parts of glabrous greenbrier rhizome and 13 parts of clematis root.
Selecting full-ingredient granular preparation (Beijing kang rentang Chinese medicinal full-ingredient granular preparation) corresponding to each component to prepare granular compound preparation, and taking one dose every day for 3 times every day. The preparation process specifically comprises the following steps: the method comprises the following steps: checking the dosage of each medicine and the required treatment course time; step two: the medicine is prepared according to the proportion of the formula of each medicine, and the equipment is selected as follows: traditional chinese medicine dispensing equipment MD6120, manufacturer: beijing and Likang Yuan medical science and technology Co., Ltd (currently, more than two levels of hospitals and some traditional Chinese medicine clinics in China use or use similar equipment); step three: the corresponding Chinese medicine preparation can be produced by Chinese medicine dispensing equipment.
Example 6
A traditional Chinese medicine composition for treating gouty arthritis comprises the following components in parts by weight: 11 parts of oldenlandia diffusa, 1.5 parts of scorpion, 9 parts of verbena, 9 parts of fructus liquidambaris, 9 parts of fried cowherb seed, 9 parts of semen plantaginis, 11 parts of Piper longum, 10 parts of lysimachia christinae, 11 parts of selfheal, 9 parts of vinegar tortoise shell, 11 parts of mulberry twig, 2 parts of prepared kusnezoff monkshood root, 11 parts of spora lygodii, 11 parts of vinegar chicken gizzard membrane, 11 parts of herba siegesbeckiae, 11 parts of glabrous greenbrier rhizome and 11 parts of clematis chinensis.
Selecting full-ingredient granular preparation (Beijing kang rentang Chinese medicinal full-ingredient granular preparation) corresponding to each component to prepare granular compound preparation, and taking one dose every day for 3 times every day. The preparation process specifically comprises the following steps: the method comprises the following steps: checking the dosage of each medicine and the required treatment course time; step two: the medicine is prepared according to the proportion of the formula of each medicine, and the equipment is selected as follows: traditional chinese medicine dispensing equipment MD6120, manufacturer: beijing and Likang Yuan medical science and technology Co., Ltd (currently, more than two levels of hospitals and some traditional Chinese medicine clinics in China use or use similar equipment); step three: the corresponding Chinese medicine preparation can be produced by Chinese medicine dispensing equipment.
The traditional Chinese medicine granules are used for treating 150 patients with chronic gouty arthritis and 75 patients with chronic gouty arthritis by adopting western medicines of allopurinol, probenecid, colchicine and the like.
The traditional Chinese medicine granule treatment group comprises 150 cases, wherein 90 cases of men and 60 cases of women are aged from 20 to 70 years old, the average age is 45 +/-1 year old, and the average course of disease is 20 +/-1 month; the medicine adopts western medicines of allopurinol, probenecid, colchicine and the like to treat 75 cases of the group with symptoms, wherein 45 cases of men and 30 cases of women are aged 20-70 years old, the average age is 44 +/-1 years old, and the average course of disease is 21 +/-1 month. The statistical analysis of the age, sex and disease course of the two groups shows no statistical significance (P is more than 0.05), and the two groups have comparability. See table 1 specifically:
table 1
Figure BDA0002480071690000101
Diagnostic criteria: acute asymmetry, swelling and pain in the toes or joints of the toes occur suddenly at night, inflammation peaks within 24 hours, and the nature and dysfunction of pain are different from that of general arthritis; after the first onset of a single facet joint, it recurs in the same or another joint, but with an asymptomatic intermission; the tophus or slow and swollen nodules near the affected joints and auricles are penetrated, sucked or broken to flow out white bean dregs-like secretion; patients with family history of gout, or history of dehydration and induction or aggravation of joint swelling and pain with diuretics; the traditional patients with hyperuricemia and joint inflammation have special treatment effect by using colchicine. Patients with different clinical manifestations and related tests were assigned different scores, gout was diagnosed when the total score was greater than or equal to 8, and when the serum uric acid level exceeded 600 μmol/L (4 points) and imaging found urate deposition (4 points), gout was confirmed even without clinical manifestations of gout.
A traditional Chinese medicine granule treatment group: the Chinese medicinal granular preparation prepared in the embodiment 1 to the embodiment 6 is treated by oral administration for 6 g/time and 3 times/day, and the treatment course is 12 days.
And (4) western medicine treatment groups: allopurinol, probenecid and colchicine are administered by oral administration for 3 times per day, with a treatment course of 12 days.
The medicine is stopped for 1 day after 6 days of each treatment, and the two groups of the medicine are respectively treated for 1 treatment course and 2 treatment courses.
The clinical efficacy of two groups after 1 treatment course is shown in Table 2, and the counting data is expressed by rate or composition ratio and is represented by χ2And (4) performing inspection, and analyzing the curative effect grade data by adopting rank sum inspection. The specific manifestations of healing are: without joint pain and the likeSymptoms are presented. The concrete manifestation of the obvious effect is as follows: no obvious symptoms such as arthralgia and the like, and the gout nodule is obviously improved. The effective concrete expression is as follows: has certain symptoms of arthralgia, and gout nodules are improved to a certain extent. The remainder are invalid.
Table 2
Figure BDA0002480071690000111
As can be seen from Table 2, the results of the Pearson chi-square test, X, were used2=58.273,P<0.001, the healing effect of the traditional Chinese medicine granule group is obviously better than that of the western medicine treatment group. (p < 0.001)
The clinical efficacy of the two groups of the medicine after 2 treatment courses is compared as shown in the table 3, and the specific manifestations of the cure are as follows: no arthralgia and other symptoms. The concrete manifestation of the obvious effect is as follows: no obvious symptoms such as arthralgia and the like, and the gout nodule is obviously improved. The effective concrete expression is as follows: has certain symptoms of arthralgia, and gout nodules are improved to a certain extent. The remainder are invalid. :
table 3
Figure BDA0002480071690000112
As can be seen from Table 3, using the Pearson chi-square test results, X2=41.410,P<0.001, the healing effect of the traditional Chinese medicine granules is obviously better than that of western medicine treatment groups. (p < 0.001)
The traditional Chinese medicine granules are used for treating 120 cases of acute gouty arthritis patients and 60 cases of acute gouty arthritis patients by adopting western medicines of allopurinol, probenecid, colchicine and the like.
The traditional Chinese medicine granule treatment group comprises 120 cases, wherein 60 cases are male and 60 cases are female; the western medicines allopurinol, probenecid, colchicine and the like are adopted for treating 60 cases of the group with symptoms, wherein 30 cases of men and 30 cases of women are adopted. The statistical analysis of the age, sex and disease course of the two groups shows no statistical significance (P is more than 0.05), and the two groups have comparability. See table 1 specifically:
the UA (serum Uric acid, blood Uric acid) change condition before and after one treatment course, the UA value (μmol/L), is specifically shown in table 4:
table 4
Figure BDA0002480071690000121
Since gouty arthritis is metabolic disorder of purine substances in human bodies, when the blood uric acid concentration is too high, uric acid is deposited in joint capsules, bursa, cartilage, bone and other tissues in the form of sodium salt, and a local tissue foreign body inflammatory reaction, namely the gouty arthritis, is caused for a long time. Therefore, when the concentration of blood uric acid in the body is reduced, the symptom of arthritis is relieved. As can be seen from the data in table 4, after a course of treatment, the values of blood uric acid are significantly reduced in examples 1 to 6, and the therapeutic effect on gout is good.
The UA (serum Uric acid, blood Uric acid) change condition before and after two treatment courses, the UA value (μmol/L), as shown in table 5, is the same as table 4 in the pre-treatment condition:
table 5
Figure BDA0002480071690000131
As can be seen from the data in Table 5, the values of blood uric acid were significantly reduced after two courses of treatment in examples 1 to 6, and there were substantially no cases exceeding 600. mu. mol/L. Therefore, the traditional Chinese medicine composition has a good treatment effect on gout.
The change of sCr (Serum creatinine ) before and after one treatment course, sCr value (μmol/L), is specifically shown in table 6:
table 6
Figure BDA0002480071690000132
Figure BDA0002480071690000141
Gout causes high blood creatinine, and is caused by damage to the kidney due to arteriosclerosis caused by gout. As can be seen from the data in table 6, the serum creatinine levels decreased significantly after a course of treatment. In examples 1 to 6, the concentration of serum creatinine decreased significantly, and was almost less than 177. mu. mol/L after a treatment course in cases where serum creatinine was 177. mu. mol/L or more. In examples 1-6, the concentration of serum creatinine decreased after a treatment course in 106-177 μmol/L cases, and some cases could be recovered to the normal range. In the western medicine treatment group, the concentration of the serum creatinine is also reduced after treatment of one treatment course, and the number of cases recovered to the normal range is obviously less than that in the examples 1 to 6.
sCr (Serum creatinine ) changes before and after two treatment courses, sCr values (μmol/L), as shown in table 7:
table 7
Figure BDA0002480071690000142
Figure BDA0002480071690000151
As can be seen from the data in Table 7, the serum creatinine levels decreased significantly after two treatment courses and returned to the normal range. However, the treatment effect of the western medicine treatment groups is obviously inferior to that of the examples 1 to 6. In examples 1 to 6, the concentration of serum creatinine decreased significantly after two treatment courses, both of which were less than 177. mu. mol/L, in cases where serum creatinine was 177. mu. mol/L or more. In examples 1-6, the concentration of serum creatinine decreased after two treatment courses in 106-177 μmol/L cases, and most cases recovered to the normal range. In the western medicine treatment group, the concentration of the serum creatinine is also reduced after two treatment courses, and the number of cases recovered to the normal range is obviously less than that in the examples 1 to 6.
In conclusion, the traditional Chinese medicine composition disclosed by the invention promotes in vivo uric acid excretion, reduces blood uric acid, regulates purine metabolic disorder, and enables a patient to comprehensively recover the autonomous metabolic function while reducing blood uric acid, so that the effect of treating gout and complications caused by gout of the patient by correcting origin is achieved, the traditional Chinese medicine composition has the advantages of good curative effect and quick response, the effect of treating both symptoms and root causes can be achieved, the pain of many patients is relieved through years of clinical application, and the harm of western medicines to the body of the patient is reduced. Therefore, the invention effectively overcomes various defects in the prior art and has high industrial utilization value.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims (9)

1. The traditional Chinese medicine composition for treating gouty arthritis is characterized by comprising the following components in parts by weight: 5-20 parts of spreading hedyotis herb, 1-4 parts of scorpion, 6-12 parts of verbena, 6-12 parts of beautiful sweetgum fruit, 6-12 parts of fried cowherb seed, 5-12 parts of semen plantaginis, 5-20 parts of yam rhizome, 7-13 parts of longhairy antenoron herb, 5-20 parts of selfheal, 5-12 parts of vinegar tortoise shell, 5-15 parts of mulberry twig, 1-4 parts of prepared kusnezoff monkshood root, 5-20 parts of Japanese climbing fern spore, 5-20 parts of vinegar chicken gizzard-membrane, 5-20 parts of siegesbeckia herb, 5-20 parts of glabrous greenbrier rhizome and 5-20 parts of clematis root.
2. The traditional Chinese medicine composition for treating gouty arthritis according to claim 1, which is characterized in that: the traditional Chinese medicine composition comprises the following components in parts by weight: 9-15 parts of spreading hedyotis herb, 1.5-3 parts of scorpion, 8-10 parts of verbena, 8-10 parts of beautiful sweetgum fruit, 8-10 parts of fried cowherb seed, 7-10 parts of salted plantain seed, 8-15 parts of yam rhizome, 10-15 parts of longhairy antenoron herb, 10-15 parts of selfheal spike, 7-10 parts of vinegar tortoise shell, 8-12 parts of mulberry twig, 1.5-3 parts of prepared kusnezoff monkshood root, 10-15 parts of climbing fern spore, 10-15 parts of vinegar chicken gizzard-membrane, 10-15 parts of herba siegesbeckiae, 10-15 parts of glabrous greenbrier rhizome and 10-15 parts of clematis root.
3. The traditional Chinese medicine composition for treating gouty arthritis according to claim 1 or 2, which is characterized in that: the traditional Chinese medicine composition comprises the following components in parts by weight: 15 parts of spreading hedyotis herb, 3 parts of scorpion, 10 parts of verbena, 10 parts of beautiful sweetgum fruit, 10 parts of fried cowherb seed, 10 parts of salted plantain seed, 15 parts of long pepper, 15 parts of longhairy antenoron herb, 15 parts of common selfheal fruit-spike, 10 parts of vinegar tortoise shell, 12 parts of mulberry twig, 3 parts of prepared kusnezoff monkshood root, 15 parts of Japanese climbing fern spore, 15 parts of vinegar chicken's gizzard-membrane, 15 parts of siegesbeckia herb, 15 parts of glabrous greenbrier rhizome and 15 parts of clematis root.
4. The traditional Chinese medicine composition for treating gouty arthritis according to claim 1 or 2, which is characterized in that: the traditional Chinese medicine composition comprises the following components in parts by weight: 12 parts of oldenlandia diffusa, 2 parts of scorpion, 8 parts of verbena, 8 parts of beautiful sweetgum fruit, 8 parts of fried cowherb seed, 8 parts of salted plantain seed, 13 parts of long pepper, 13 parts of longhairy antenoron herb, 13 parts of selfheal, 8 parts of vinegar tortoise shell, 10 parts of mulberry twig, 2 parts of prepared kusnezoff monkshood root, 13 parts of lygodium japonicum, 13 parts of vinegar chicken's gizzard-membrane, 13 parts of siegesbeckia herb, 13 parts of glabrous greenbrier rhizome and 13 parts of clematis root.
5. The preparation method of the traditional Chinese medicine composition for treating gouty arthritis according to any one of claims 1 to 4, which is characterized by comprising the following steps: adding the herba Hedyotidis Diffusae, Scorpio, herba Verbenae, fructus Lipuidambaris, parched semen Vaccariae, Sal semen plantaginis, rhizoma Dioscoreae Septemlobae, herba Lysimachiae Christinae, Prunellae Spica, vinegar carapax et Plastrum Testudinis, ramulus Mori, radix Aconiti Kusnezoffii Preparata, spora Lygodii, vinegar endothelium corneum Gigeriae Galli, Siegesbeckiae herba, rhizoma Smilacis Glabrae and radix Clematidis into a pulverizer according to the above ratio, pulverizing, and sieving.
6. The preparation method of the traditional Chinese medicine composition for treating gouty arthritis according to any one of claims 1 to 4, which is characterized by comprising the following steps: adding the herba Hedyotidis Diffusae, Scorpio, herba Verbenae, fructus Lipuidambaris, parched semen Vaccariae, Sal semen plantaginis, rhizoma Dioscoreae Septemlobae, herba Lysimachiae Christinae, Prunellae Spica, vinegar carapax et Plastrum Testudinis, ramulus Mori, radix Aconiti Kusnezoffii Preparata, spora Lygodii, vinegar endothelium corneum Gigeriae Galli, Siegesbeckiae herba, rhizoma Smilacis Glabrae and radix Clematidis into a decocting device according to the above ratio, decocting, and concentrating.
7. A traditional Chinese medicine preparation containing the traditional Chinese medicine composition for treating gouty arthritis according to any one of claims 1 to 4, wherein the traditional Chinese medicine preparation consists of the traditional Chinese medicine composition according to any one of claims 1 to 4 and a pharmaceutically acceptable carrier and/or excipient.
8. The use of the Chinese medicinal composition for treating gouty arthritis according to any one of claims 1 to 4 for treating gout.
9. The use according to claim 8, wherein the gout is acute gouty arthritis or chronic gouty arthritis.
CN202010376008.3A 2020-05-07 2020-05-07 Traditional Chinese medicine composition for treating gouty arthritis, preparation method, preparation and application Pending CN111358882A (en)

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