CN110960592A - Traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis and preparation method thereof Download PDF

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CN110960592A
CN110960592A CN201911143459.6A CN201911143459A CN110960592A CN 110960592 A CN110960592 A CN 110960592A CN 201911143459 A CN201911143459 A CN 201911143459A CN 110960592 A CN110960592 A CN 110960592A
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medicine composition
cholelithiasis
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秦江玮
刘泳江
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285Aucklandia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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Abstract

The invention discloses a traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis, which comprises the following components: fructus aurantii, honeysuckle, radix bupleuri, fructus forsythiae, great burdock achene, elecampane, liquorice and ricepaperplant pith. The prescription of the invention has reasonable compatibility, can effectively improve the synergistic effect among the medicines, soothes liver and promotes bile flow, clears heat and promotes diuresis, promotes qi circulation and relieves pain, promotes bile flow and removes calculus, has no obvious hepatorenal toxicity, can be widely applied to the treatment of cholecystitis with cholelithiasis, and has the advantage of treating both principal and secondary aspect of disease.

Description

Traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis and preparation method thereof
Technical Field
The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis and a preparation method thereof.
Background
The cholecystitis is mainly chronic cholecystitis, namely chronic pathological changes of gallbladder, is a common disease clinically, has high incidence rate, most of combined cholecystolithiasis is also called cholelithiasis, and a few of non-cholelithiasis chronic cholecystitis is mostly chronic and can be caused by repeated attack of acute cholecystitis. Clinically, it is manifested as pain and discomfort in the upper abdomen or right monster, postprandial upper abdominal distention, dyspepsia, and jaundice. Modern medicine considers that the occurrence of cholecystitis is mainly caused by the stimulation of gallstones and invading bacteria or viruses to gall bladder, so that chronic cholecystitis is usually accompanied by the existence of gallstones, so that the contraction function of the gall bladder is reduced, the bile excretion capability of the gall bladder is also reduced, and gallstones are easily formed. If timely and effective treatment is not clinically adopted, the normal operation of the digestive system is affected to different degrees. According to the traditional Chinese medicine, the cholelithiasis complicated with chronic cholecystitis belongs to the categories of costalgia, gallbladder distention and the like, and the incidence causes of the cholelithiasis are considered to be liver qi stagnation and heat transformation due to depression caused by emotional, diet, exogenous evil and the like, so that damp heat of liver and gallbladder is formed, or the liver qi stagnation and blood stasis caused by long-term liver qi stagnation causes qi stagnation and blood stasis, qi movement of middle jiao is disordered, liver collaterals are not smooth, and the gallbladder loses the smooth flow, so that the right upper abdomen or the hypochondrium is distended and painful. Western medicine treatment, namely anti-inflammatory treatment, is adopted clinically, and patients often need to use a large amount of antibiotics, so that the in-vivo flora is easily unbalanced and the health is affected.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition which can sooth liver, promote bile flow, clear heat, promote diuresis, promote qi circulation, relieve pain, promote bile flow and remove urinary calculus, has no obvious hepatorenal toxicity and can be widely applied to treatment of cholecystitis complicated with cholelithiasis, and a preparation method thereof.
The technical scheme adopted by the invention is as follows: a Chinese medicinal composition for treating cholecystitis complicated with cholelithiasis comprises fructus Aurantii, flos Lonicerae, bupleuri radix, fructus forsythiae, fructus Arctii, radix aucklandiae, Glycyrrhrizae radix, and medulla Tetrapanacis;
furthermore, the weight parts of the components are 25-30 parts of fructus aurantii, 25-30 parts of honeysuckle, 15-20 parts of radix bupleuri, 15-20 parts of fructus forsythiae, 5-10 parts of burdock, 5-10 parts of elecampane, 1-5 parts of liquorice and 1-5 parts of ricepaperplant pith;
further, the weight parts of the components are 27-30 parts of fructus aurantii, 27-30 parts of honeysuckle, 16-18 parts of radix bupleuri, 16-18 parts of fructus forsythiae, 8-10 parts of burdock, 5-7 parts of elecampane, 2-4 parts of liquorice and 2-4 parts of ricepaperplant pith;
further, the dosage form of the traditional Chinese medicine composition is selected from: decoction, capsule, tablet or powder;
furthermore, the dosage form of the traditional Chinese medicine composition is preferably tablets or decoction.
The invention also discloses a preparation method of the traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis, and when the dosage form of the traditional Chinese medicine composition is a tablet, the preparation method comprises the following steps:
grinding the raw materials, sieving, mixing, adding water 20-40 times the weight of the mixture, soaking for 1-2 hr, decocting for 1-2 hr, filtering the decoction, decocting with strong fire until the decoction becomes eight dry, adding excipient into the thick liquid, and tabletting to obtain the final product;
when the dosage form of the traditional Chinese medicine composition is decoction, the preparation method comprises the following steps:
grinding the raw materials, sieving, mixing, adding water 20-40 times the weight of the mixture, soaking for 1-2 hr, decocting for 1-2 hr, filtering, and decocting with strong fire until the decoction is thick.
The traditional Chinese medicine composition provided by the invention has the following analysis of the medicines:
fructus Aurantii, bitter and pungent in flavor, cool in nature, enters lung, spleen and large intestine channels, breaks qi, moves phlegm, and removes food stagnation.
Honeysuckle flower, sweet in taste and cold in nature, can clear away heat and toxic material. It is indicated for epidemic febrile disease, fever, bloody dysentery, carbuncle and external diseases, swelling, scrofula and anal fistula.
Bupleurum root, radix bupleuri, bitter in taste, cool in nature, harmonizes exterior and interior, soothes liver and raises yang. It is used to treat alternating cold and heat, fullness in chest, hypochondriac pain, bitter taste in mouth, deafness, headache, blurred vision, malaria, prolapse of anus, menoxenia, and metroptosis.
Fructus forsythiae is bitter in taste and cool in nature, and has the effects of clearing heat, detoxifying, dissipating stagnation and reducing swelling. It is indicated for warm heat, erysipelas, macula, superficial infection, abscess, swelling, scrofula and stranguria.
The burdock is pungent and bitter in taste and cold in nature, enters lung and stomach meridians, disperses wind and heat, clears away heat and toxic materials, promotes eruption, ventilates lung, relieves sore throat and swells.
Mu Xiang is pungent and bitter in flavor, warm in nature, can promote the circulation of qi, alleviate pain, invigorate the spleen and promote digestion.
Licorice root, radix Glycyrrhizae is sweet in taste and neutral in nature, regulates the middle warmer and relieves urgency, moistens the lung, detoxifies the toxin, and harmonizes the effects of the other drugs. It is stir-baked to treat weakness of spleen and stomach, poor appetite, abdominal pain, loose stool, fatigue, fever, consumptive lung disease, cough, palpitation, fright epilepsy; unprocessed, indicated for swollen and sore throat, peptic ulcer, abscess, deep-rooted carbuncle, sores and ulcers, relieving toxicity of herbs and food poisoning.
Medulla Tetrapanacis, sweet in flavor, neutral in nature, and capable of clearing heat, promoting diuresis and promoting lactation.
The invention has the beneficial effects that:
1) the bitter orange is generally considered to be capable of strengthening spleen, stimulating appetite, benefiting qi in chest, strengthening five internal organs and dispersing accumulation of pathogenic factors by matching honeysuckle flowers which are also capable of clearing heat and removing toxicity together as a monarch drug, and can take effects of dispersing stasis, regulating qi, soothing liver and reducing fever by matching the bupleurum for soothing liver and invigorating yang and the forsythia for dispersing accumulation and reducing swelling as ministerial drugs; and fructus arctii capable of clearing heat and removing toxicity, elecampane capable of promoting qi circulation and relieving pain and medulla Tetrapanacis capable of relaxing bowels and removing stagnation are taken as adjuvant drugs, and liquorice is used for harmonizing the drugs and has the synergistic effect of soothing liver, promoting bile flow and removing stagnation, wherein the addition of the elecampane can play a role in tonifying spleen and protecting liver, so that the effects of dispelling damp heat, promoting bile flow and removing calculus are played, and the traditional Chinese medicine is very effective in improving cholecystitis complicated with cholelithiasis.
2) The formula of the invention is characterized by the mutual compatibility of monarch, minister, assistant and guide, has reasonable formula, can effectively improve the synergistic effect among the medicines, can evacuate stagnated gallbladder qi, and drain bile as usual, has no obvious toxic or side effect, is a good choice for non-western medicine treatment of cholecystitis complicated with cholelithiasis, and is worthy of clinical popularization.
Detailed Description
Example 1:
the traditional Chinese medicine for treating cholecystitis complicated with cholelithiasis is prepared from the following raw material medicines in parts by weight: 28 parts of fructus aurantii, 28 parts of honeysuckle, 16 parts of radix bupleuri, 16 parts of fructus forsythiae, 8 parts of great burdock achene, 5 parts of elecampane, 2 parts of liquorice and 2 parts of ricepaperplant pith.
The preparation method comprises the following specific steps:
grinding the raw materials, sieving, mixing, adding water 40 times the weight of the mixture, soaking for 1 hr, decocting for 2 hr, filtering the decoction, decocting with strong fire until the decoction becomes dried, adding sufficient starch into the thick liquid, tabletting, and air drying to obtain the final product.
Example 2:
the traditional Chinese medicine for treating cholecystitis complicated with cholelithiasis is prepared from the following raw material medicines in parts by weight: 28 parts of fructus aurantii, 28 parts of honeysuckle, 16 parts of radix bupleuri, 16 parts of fructus forsythiae, 8 parts of great burdock achene, 7 parts of elecampane, 4 parts of liquorice and 2 parts of ricepaperplant pith.
The preparation method comprises the following specific steps:
grinding the raw materials, sieving, mixing, adding water 40 times the mass of the mixture, soaking for 1 hr, decocting for 2 hr, filtering the decoction, and decocting with strong fire until the decoction is thick.
Example 3:
clinical diagnosis standard:
1) the patients have a history of acute or chronic cholecystitis or cholelithiasis.
2) Symptoms are: epigastric or seasonal costal pain or shoulder and back discomfort, which may be followed by abdominal distention, belching, hiccup and dyspepsia, and often after eating greasy food, the symptoms are obvious, and there may be a history of biliary colic attack.
3) Physical signs: the gallbladder area may have tenderness and swelling.
4) Auxiliary inspection:
① gallbladder shadow, light image, no development or deformation, delayed evacuation or calculus shadow;
② B ultrasonic wave, which indicates that the gallbladder wall is rough and thickened or not smooth, and positive calculus shadow can be seen;
③ CT, showing the increased wall thickness of gallbladder, the increased thickness of bile duct and the stone shadow;
④ duodenum drainage has bile concentration defect, microscopic examination of concentrated cells, cholesterol, calcium bilirubinate crystal, and pathogenic bacteria,
(II) according to the national collaboration network conference of the national traditional Chinese medicine medical center of the national traditional Chinese medicine administration, the standard is formulated (1999):
and (3) healing: the pain and discomfort of the right upper abdomen and the like disappear, the tenderness and the percussion pain of the middle upper abdomen and the right upper abdomen disappear, the gallbladder wall returns to normal through B-ultrasonic examination, and the calculus disappears;
the effect is shown: the pain and discomfort of the right upper abdomen and the like are obviously relieved, the tenderness and the percussion pain of the middle upper abdomen and the right upper abdomen are obviously relieved, 2 or more items of 3 items of thickening, roughness and sound transmission of the gallbladder wall are improved in B ultrasonic examination, the volume of the calculus is reduced by more than 0.5cm, or the number of the calculus is reduced by more than 1/3;
the method has the following advantages: relieving symptoms such as pain and discomfort of the right upper abdomen, relieving tenderness and percussion pain of the middle upper abdomen and the right upper abdomen, improving 1 or more of 3 items of thickening, roughness and sound transmission of the gallbladder wall in B ultrasonic examination, reducing the calculus volume by more than 0.2cm or reducing the calculus number by less than 1/3;
and (4) invalidation: no relief of symptoms, no improvement of gallbladder wall thickening, roughness and sound transmission in B ultrasonic examination, no change of calculus volume, or increase of calculus.
And (III) 120 patients 50-70 years old who participate in statistics are divided into a tablet treatment group, a decoction treatment group and a control group, wherein each group comprises 40 persons:
tablet treatment group: taken orally after morning meal and after lunch, 3 tablets (about 0.2 g/tablet) at a time, twice a day, and two months consecutively;
the decoction treatment group comprises: orally taking 200ml once and twice a day after morning meal and continuously taking for two months;
control group: the oral antiphlogistic cholagogic tablet is 6 tablets once and three times a day, and is taken for two months continuously.
Group of Cure of disease Show effect Is effective Invalidation Total effective rate
Tablet set 24 12 3 1 97.5%
Decoction set 20 15 2 3 92.5%
Control group 14 11 8 7 82.5%
Therefore, the total effective rate of the groups treated by using the traditional Chinese medicine composition is slightly different, which shows that the adjustment of the components of the costustoot and the liquorice has influence on the drug effect, and no obvious hepatorenal toxicity or other toxic and side effects are found during the treatment period.

Claims (7)

1. A traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis is characterized by comprising fructus aurantii, honeysuckle, radix bupleuri, fructus forsythiae, great burdock achene, elecampane, liquorice and ricepaperplant pith.
2. The traditional Chinese medicine composition according to claim 1, wherein the weight parts of the components are 25-30 parts of fructus aurantii, 25-30 parts of honeysuckle, 15-20 parts of radix bupleuri, 15-20 parts of fructus forsythiae, 5-10 parts of burdock, 5-10 parts of elecampane, 1-5 parts of liquorice and 1-5 parts of ricepaperplant pith.
3. The traditional Chinese medicine composition according to claim 2, wherein the weight parts of the components are 27-30 parts of fructus aurantii, 27-30 parts of honeysuckle, 16-18 parts of radix bupleuri, 16-18 parts of fructus forsythiae, 8-10 parts of burdock, 5-7 parts of elecampane, 2-4 parts of liquorice and 2-4 parts of ricepaperplant pith.
4. The traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis according to any one of claims 1 to 3, wherein a dosage form of the traditional Chinese medicine composition is selected from the group consisting of: decoction, capsule, tablet or powder.
5. The traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis as claimed in claim 4, wherein the dosage form of the traditional Chinese medicine composition is selected from tablets or decoction.
6. A preparation method of the traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis as claimed in any one of claims 1 to 5, which is characterized in that: when the dosage form of the traditional Chinese medicine composition is a tablet, the traditional Chinese medicine composition comprises the following components:
grinding the raw materials, sieving, mixing, adding water 20-40 times the weight of the mixture, soaking for 1-2 hr, decocting for 1-2 hr, filtering the decoction, decocting with strong fire until the decoction becomes eight dry, adding excipient into the thick liquid, and tabletting.
7. A preparation method of the traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis as claimed in any one of claims 1 to 5, which is characterized in that: when the dosage form of the traditional Chinese medicine composition is decoction, the traditional Chinese medicine composition comprises the following components:
grinding the raw materials, sieving, mixing, adding water 20-40 times the weight of the mixture, soaking for 1-2 hr, decocting for 1-2 hr, filtering, and decocting with strong fire until the decoction is thick.
CN201911143459.6A 2019-11-20 2019-11-20 Traditional Chinese medicine composition for treating cholecystitis complicated with cholelithiasis and preparation method thereof Withdrawn CN110960592A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111346143A (en) * 2020-03-27 2020-06-30 王菲菲 Traditional Chinese medicine composition for regulating liver depression and qi stagnation type obesity and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111346143A (en) * 2020-03-27 2020-06-30 王菲菲 Traditional Chinese medicine composition for regulating liver depression and qi stagnation type obesity and preparation method thereof

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