CN105943863A - Traditional Chinese medicine for preventing and treating contrast-induced nephropathy and preparation method thereof - Google Patents
Traditional Chinese medicine for preventing and treating contrast-induced nephropathy and preparation method thereof Download PDFInfo
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- CN105943863A CN105943863A CN201610492249.8A CN201610492249A CN105943863A CN 105943863 A CN105943863 A CN 105943863A CN 201610492249 A CN201610492249 A CN 201610492249A CN 105943863 A CN105943863 A CN 105943863A
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Abstract
The invention discloses a traditional Chinese medicine for preventing and treating contrast-induced nephropathy and a preparation method thereof. The traditional Chinese medicine is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 20 to 30 parts of rheum officinale, 20 to 30 parts of rabdosia rubescens, 20 to 30 parts of dandelion, 15 to 25 parts of japan clover herb, 15 to 25 parts of dicliptera chinensis, 15 to 25 parts of acanthopanax, 10 to 20 parts of purple flower holly leaf, 10 to 20 parts of fruit of princesplume ladysthumb, 5 to 15 parts of cypripedium macranthum, 5 to 15 parts of polyporus umbellatus, 5 to 15 parts of aconitum napellus, 2 to 8 parts of cassia twig, 2 to 8 parts of verbena, 2 to 8 parts of euphorbia pekinensis and 1 to 5 parts of moleplant seed. The traditional Chinese medicine for preventing and treating contrast-induced nephropathy disclosed by the invention takes common traditional Chinese medicinal raw materials as raw materials, is scientific in formula, low in cost and exact in treatment effect, does not have side effects, has the effects of clearing heat, detoxifying, inducing diuresis for removing edema, promoting blood circulation to remove blood stasis and invigorating the spleen for eliminating dampness, and can effectively prevent and treat contrast-induced nephropathy.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preventing and treating contrast induced nephropathy and preparation thereof
Method.
Background technology
Contrast induced nephropathy is the important complication in iodine contrast medium application process, is also the important of iatrogenic renal failure
Ingredient, it is not only unfavorable to the clinical prognosis of patient, and increases the medical expense of patient.Along with shadowgraph technique is in clinic
On extensive application, particularly at advanced age, have the application in serious complication patient, make contrast induced nephropathy (CIN) become hospital
The third-largest main cause of acquired renal failure, accounts for the 11% of sickness rate.CIN refers to that patient is accepting contrast examination or Jie
During entering treatment, iodine contrast medium (2-3) d after getting rid of other kidney damage factors, is used to occur that serum creatinine level raises,
Renal function urgency gallop is caused to decline.It is embodied in: using 48-72h after contrast medium, serum creatinine level rises 44 μm ol/L,
Or rise 25% than basal serum creatinine level.The Pathophysiology research of CIN is the most relevant to 3 factors: 1. iodine preparation is straight
Connect Nephrotoxicity；2. kidney Microembolization；3. the contraction of blood vessel in the kidney that contrast medium and thrombosis cause.
CIN once there is no highly effective countermeasure at present, and therefore CIN preventing and treating more needs to provide for a rainy day.Modern medicine is main
Prevent from methods such as reducing the consumption of contrast medium, hydration treatment, renal replacement therapies (including hemodialysis, peritoneal dialysis etc.)
The generation of CIN.Although renal replacement therapies technology has greatly improved in recent years, but during due to renal failure, human body goes out
The most serious interior environment disturbance, and it often merges Multiple organ dysfunction, case fatality rate is the highest.
Western medical treatment mainly has the treatment of hydration treatment, anti-oxidation medicine, intravenous injection acetylcysteine, he is administered orally at present
Spit of fland class medicine and oral vitamin E etc..But effect is not notable, and there is certain side effect.The traditional Chinese medical science is thought, contrast induced nephropathy
Belonging to the category such as " difficulty in urination ", " obstruction and rejection ", Etiological is divided into more, and one is to invade in evil poison: the misuse of the nephrotoxic drugs such as contrast medium
Or with improper；Two is to stop in blood stasis: various diseases cause functional activity of QI being not smooth, blood-stasis internal-depression；Or poison evil impairing the spleen and stomach, taste gas
Weak, blood stasis due to qi deficiency；Three is battalion's the moon consume: Shi Re Bing Pian, and closing are in interior, and burn battalion's consumption the moon, nutrient QI and YIN-fluid being damaged, and feel frustrated de-, nephrons of Tianjin is subject to
Damage.The various causes of disease, make the dirty regulation to water liquid of lung, spleen, kidney three not normal, or make stagnation of QI due to depression of the liver, functioning of bladder be obstructed, the wet congestion of water
In interior and fall ill.Chinese medicine achieves preferable curative effect at contrast induced nephropathy, is improving salvage success rate, is improving life quality etc.
Aspect has certain advantage.
Summary of the invention
An object of the present invention is to provide one and prepares simply, determined curative effect, the preventing and treating contrast induced nephropathy having no side effect
Chinese medicine.
In order to solve above-mentioned technical problem, the technical solution adopted in the present invention is:
A kind of Chinese medicine preventing and treating contrast induced nephropathy, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from: Radix Et Rhizoma Rhei 20-30
Part, Rabdosia rubescens 20-30 part, Herba Taraxaci 20-30 part, Herba Kummerowiae Striatae 15-25 part, Herba Diclipterae Chinensis 15-25 part, Radix Et Caulis Acanthopanacis Senticosi 15-25 part, the four seasons
Blue or green 10-20 part, Fructus Polygoni Orientalis 10-20 part, Radix Cypripedii tibetici 5-15 part, Polyporus 5-15 part, Radix Aconiti Lateralis Preparata 5-15 part, Ramulus Cinnamomi 2-8 part, Herba Verbenae
2-8 part, Radix Euphorbiae Pekinensis 2-8 part, Semen Euphorbiae 1-5 part.
A kind of Chinese medicine preventing and treating contrast induced nephropathy, preferred scheme, take off and state the raw material of Chinese medicine of weight proportion and prepare
Form: Radix Et Rhizoma Rhei 23-27 part, Rabdosia rubescens 23-27 part, Herba Taraxaci 23-27 part, Herba Kummerowiae Striatae 18-22 part, Herba Diclipterae Chinensis 18-22 part, thorn five
Add 18-22 part, Ilex purpurea Hassk.[I.chinensis Sims 13-17 part, Fructus Polygoni Orientalis 13-17 part, Radix Cypripedii tibetici 8-12 part, Polyporus 8-12 part, Radix Aconiti Lateralis Preparata 8-12 part, osmanthus
Branch 4-6 part, Herba Verbenae 4-6 part, Radix Euphorbiae Pekinensis 4-6 part, Semen Euphorbiae 2-4 part.
A kind of Chinese medicine preventing and treating contrast induced nephropathy, scheme more preferably, take off the raw material of Chinese medicine stating weight proportion
It is prepared from: Radix Et Rhizoma Rhei 25 parts, Rabdosia rubescens 25 parts, Herba Taraxaci 25 parts, Herba Kummerowiae Striatae 20 parts, Herba Diclipterae Chinensis 20 parts, Radix Et Caulis Acanthopanacis Senticosi 20 parts, the four seasons
Blue or green 15 parts, Fructus Polygoni Orientalis 15 parts, Radix Cypripedii tibetici 10 parts, Polyporus 10 parts, Radix Aconiti Lateralis Preparata 10 parts, Ramulus Cinnamomi 5 parts, Herba Verbenae 5 parts, 5 parts, the Radix Euphorbiae Pekinensis, thousand
Gold 3 parts.
Preferably, the Chinese medicine of above-mentioned preventing and treating contrast induced nephropathy is Chinese medicine oral liquid.
It is a further object of the present invention to provide the preparation method of the Chinese medicine of above-mentioned preventing and treating contrast induced nephropathy.
A kind of preparation method of the Chinese medicine preventing and treating contrast induced nephropathy, step is as follows:
Step one: said herbal medicine remove impurity be placed in marmite, adds water soaking 50-70 minute of raw material weight 6-10 times, so
After with high heat decoct to boiling after, use instead slow fire continue decoct 35-45min, filter, leach medicinal residues, obtain decocting liquid first, then
Adding the water of raw material weight 3-7 times in filtering residue, intense fire decocts to boiling, and slow fire continues to decoct 15-25min, filters, obtains
Secondary decocting liquid, merges twice decocting liquid, obtains filtrate；
Step 2: filtrate step one obtained is condensed into and surveys relative density at 60 DEG C is the clear paste of 1.15-1.25, adds ethanol extremely
It is 60% containing amount of alcohol, then stirs evenly, stand, filter, take filtrate recycling ethanol, be condensed into the extractum containing solid weight 65-67%,
Add simple syrup 10%, refined honey 12%, preservative 2%, stock solution embedding, irradiation sterilization, packed products, obtain the present invention and prevent and treat contrast
The Chinese medicine of agent nephropathy.
The preparation method of the Chinese medicine of above-mentioned preventing and treating contrast induced nephropathy, adds the water soaking of raw material weight 8 times in step one
60 minutes, decoct to boiling the most with high heat, use slow fire instead and continue to decoct 40min, filter, leach medicinal residues, decocted first
Liquid, then adds the water of raw material weight 5 times in filtering residue, and intense fire decocts to boiling, and slow fire continues to decoct 20min, filters,
To secondary decocting liquid.
The preparation method of the Chinese medicine of above-mentioned preventing and treating contrast induced nephropathy, filtrate step one obtained in step 2 concentrates
Becoming 60 DEG C of survey relative densities is the clear paste of 1.2, and adding ethanol to making containing amount of alcohol is 60%, stirs evenly, and stands, and filters, takes filtrate and return
Receive ethanol, be condensed into the extractum containing solid weight 66%.
The preparation method of the Chinese medicine of above-mentioned preventing and treating contrast induced nephropathy, it is preferred that described preservative is sodium benzoate, mountain
One or both in pears acid.
Used by the present invention, the pharmacology of main raw material of Chinese medicine is as follows:
Radix Et Rhizoma Rhei: cold in nature, bitter in the mouth.Return spleen channel, stomach warp, large intestine channel, Liver Channel, pericardium channel.Effect and effect: purging heat to relax the bowels, removing heat from blood solution
Poison, eliminating blood stasis and inducing menstruation.With controlling, excess-heat constipation, stagnant stomachache, dysentery be not well, jaundice due to damp-heat, heat in blood tell nosebleed, conjunctival congestion, pharyngeal swelling, acute appendicitis furuncle
Skin ulcer, blood stasis amenorrhea, traumatic injury.
Rabdosia rubescens: cold nature, bitter in the mouth, sweet.Return lung meridian, stomach warp, Liver Channel.Effect and effect: heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.
With controlling laryngopharynx swelling and pain, addiction abdominal mass mass in the abdomen, snake bite and insect sting.
Herba Taraxaci: cold in nature, bitter in the mouth, sweet.Return Liver Channel, stomach warp.Effect and effect: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Treat acute
Mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis,
Gastritis, hepatitis, cholecystitis, urinary tract infection.
Herba Kummerowiae Striatae: cool in nature, bitter in the mouth.Return stomach warp, large intestine channel.Effect and effect: heat-clearing and toxic substances removing, invigorating spleen to remove dampness.With curing cold
Heating, heat-damp in summer vomiting and diarrhoea, dysentery, jaundice due to damp-heat, pyretic stranguria, nebulousurine.
Herba Diclipterae Chinensis: sweet in the mouth, micro-hardship, cool in nature.GUIXIN warp, Liver Channel, lung meridian.Effect and effect: clearing away heat and cooling blood, diuresis removing toxic substances.
By the heating that cures cold, cough due to lung-heat, laryngopharynx swelling and pain, wind heat conjunctival congestion and infantile hyperpyrexia infantile convulsion；Macule caused by heat in blood and haematemesis, nosebleed
The hemorrhage such as blood, hematuria；Hygropyretic dysentery, dysuria, women leucorrhea.
Radix Et Caulis Acanthopanacis Senticosi: hardship pungent, micro-, temperature.Return spleen, kidney, heart channel.Function cures mainly: replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For spleen kidney yang
Void, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Ilex purpurea Hassk.[I.chinensis Sims: cool in nature is bitter in the mouth, puckery.Return lung meridian, large intestine channel, bladder warp.Effect and effect: heat-clearing and toxic substances removing, detumescence is dispelled
The stasis of blood.With controlling cough due to lung-heat, laryngopharynx swelling and pain, dysentery, hypochondriac pain, pyretic stranguria；Externally treating burns and scalds, skin ulcer.
Fructus Polygoni Orientalis: be slightly cold, salty in the mouth.Return Liver Channel, stomach warp.Effect and effect: repercussive removing mass, invigorating spleen to remove dampness, whole body pain relieving.
Treatment flank levy long-pending, dropsy, have a stomach-ache, lack of appetite abdominal distention, acute catarrhal conjunctivitis, skin ulcer are swollen, scrofula.
Radix Cypripedii tibetici: bitter, tepor, slightly poisonous.Function cures mainly: diuresis, detumescence, and pain relieving is invigorated blood circulation.Dispelling the wind and dampness pathogens lumbago and skelalgia, lower limb
Edema, traumatic injury, gonorrhea, leucorrhea.
Polyporus: property is put down, sweet in the mouth is light.Return kidney channel, bladder warp.Effect and effect: diuresis eliminating dampness by diuresis.With controlling dysuria, water
Swell, have loose bowels, stranguria with turbid discharge, leukorrhagia.
Radix Aconiti Lateralis Preparata: property heat, acrid in the mouth, sweet, very toxic.GUIXIN warp, kidney channel, spleen channel.Effect and effect: recuperating depleted YANG and rescuing the patient from collapse, mend fire and help
Sun, dispersing cold for relieving pain.Collapse for YANG-depletion, cold extremities faint pulse, deficiency of heart-YANG, obstruction of qi in the chest and cardialgia, deficiency and coldness vomiting and diarrhoea, coldness and pain in the epigastrium, insufficiency of kidney-YANG
Decline, sexual impotence cold womb, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.Return bladder warp, heart channel, lung meridian.Effect and effect: relieving muscles diaphoresis, warming the meridian and promoting blood circulation, help
Yang transforming qi, the flat gas that spins, belong to pungent and warm medicine for relieving the exterior syndrome.Experiment shows, cinnamic aldehyde also have convulsion, antibacterial, antiviral, expansion blood vessel and
Antiinflammatory action.With controlling anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Herba Verbenae: cool in nature, bitter in the mouth.Return Liver Channel, spleen channel.Effect and effect: promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.
With controlling abdominal mass accumulation, amenorrhea dysmenorrhea, malaria, sore throat, edema, pyretic stranguria.
The Radix Euphorbiae Pekinensis: cold in nature, bitter in the mouth.Return lung meridian, spleen channel, kidney channel.Effect and effect: removing water retention by purgation drink, profit two are just.Application for the treatment of is chronic
Oedema due to nephritis, dropsy, phlegm retention, scrofula, swollen ulcer drug.
Semen Euphorbiae: warm in nature, acrid in the mouth.Return Liver Channel, kidney channel, large intestine channel.Effect and effect: detumescence of relieving oedema or abdominal distension through diuresis or purgation, removing blood stasis disappear.Treatment
Edema, phlegm retention, stagnant distension, constipation and anuresis, blood stasis amenorrhea；Suitable amount used externally, mashes deposited affected part, controls stubborn dermatitis, warty vegetation.
Compared with prior art, the invention have the benefit that
The present invention prevents and treats the Chinese medicine of contrast induced nephropathy, use Common Chinese Herbs as raw material, scientific formulation, with low cost,
Determined curative effect, has no side effect, and has effect of heat-clearing and toxic substances removing, inducing diuresis to remove edema, blood circulation promoting and blood stasis dispelling, invigorating spleen to remove dampness, and it is right effectively to prevent and treat
Ratio agent nephropathy.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited by this.
Embodiment 1 one kinds prevents and treats the Chinese medicine of contrast induced nephropathy, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from
(every part takes 1g): Radix Et Rhizoma Rhei 20 parts, Rabdosia rubescens 20 parts, Herba Taraxaci 20 parts, Herba Kummerowiae Striatae 15 parts, Herba Diclipterae Chinensis 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, four
Blue or green 10 parts of season, Fructus Polygoni Orientalis 10 parts, Radix Cypripedii tibetici 5 parts, Polyporus 5 parts, Radix Aconiti Lateralis Preparata 5 parts, Ramulus Cinnamomi 2 parts, Herba Verbenae 2 parts, 2 parts, the Radix Euphorbiae Pekinensis, thousand
Gold 1 part.
The preparation method of the Chinese medicine of above-mentioned preventing and treating contrast induced nephropathy, step is as follows:
Step one: said herbal medicine remove impurity be placed in marmite, adds the water soaking 50 minutes of raw material weight 6 times, then uses force
Fire decocts to boiling, uses slow fire instead and continues to decoct 35min, filters, leach medicinal residues, obtain decocting liquid first, then in filtering residue
Adding the water of raw material weight 3 times, intense fire decocts to boiling, and slow fire continues to decoct 15min, filters, obtains secondary decocting liquid, merges
Twice decocting liquid, obtains filtrate；
Step 2: filtrate step one obtained is condensed into and surveys relative density at 60 DEG C is the clear paste of 1.15, adds ethanol to containing second
Alcohol amount is 60%, then stirs evenly, and stands, and filters, takes filtrate recycling ethanol, is condensed into the extractum containing solid weight 65, adds monosaccharide
Slurry 10%, refined honey 12%, preservative 2%, stock solution embedding, irradiation sterilization, packed products, obtain the present invention and prevent and treat contrast induced nephropathy
Chinese medicine.
Model case one: week xx, female, 53 years old, people from Jinan.Patient occurs the symptom of oliguria after using contrast agent, goes doctor
Institute checks, is diagnosed as radiographic contrast nephropathy, takes the Chinese medicine treatment in the embodiment of the present invention 1, and after taking 5 days, symptom is obvious
Take a turn for the better, continue to take 5 days, transference cure, follow up a case by regular visits to so far without recurrence.
Embodiment 2 one kinds prevents and treats the Chinese medicine of contrast induced nephropathy, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from
(every part takes 1g): Radix Et Rhizoma Rhei 30 parts, Rabdosia rubescens 30 parts, Herba Taraxaci 30 parts, Herba Kummerowiae Striatae 25 parts, Herba Diclipterae Chinensis 25 parts, Radix Et Caulis Acanthopanacis Senticosi 25 parts, four
Blue or green 20 parts of season, Fructus Polygoni Orientalis 20 parts, Radix Cypripedii tibetici 15 parts, Polyporus 15 parts, Radix Aconiti Lateralis Preparata 15 parts, Ramulus Cinnamomi 8 parts, Herba Verbenae 8 parts, 8 parts, the Radix Euphorbiae Pekinensis,
Semen Euphorbiae 5 parts.
The preparation method of the Chinese medicine of above-mentioned preventing and treating contrast induced nephropathy, step is as follows:
Step one: said herbal medicine remove impurity be placed in marmite, adds the water soaking 70 minutes of raw material weight 10 times, then uses force
Fire decocts to boiling, uses slow fire instead and continues to decoct 45min, filters, leach medicinal residues, obtain decocting liquid first, then in filtering residue
Adding the water of raw material weight 7 times, intense fire decocts to boiling, and slow fire continues to decoct 25min, filters, obtains secondary decocting liquid, merges
Twice decocting liquid, obtains filtrate；
Step 2: filtrate step one obtained is condensed into and surveys relative density at 60 DEG C is the clear paste of 1.25, adds ethanol to containing second
Alcohol amount is 60%, then stirs evenly, and stands, and filters, takes filtrate recycling ethanol, is condensed into the extractum containing solid weight 67%, adds single
Syrup 10%, refined honey 12%, sorbic acid 2%, stock solution embedding, irradiation sterilization, packed products, obtain the present invention and prevent and treat contrast induced nephropathy
Chinese medicine.
Embodiment 3 one kinds prevents and treats the Chinese medicine of contrast induced nephropathy, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from
(every part takes 1g): Radix Et Rhizoma Rhei 23 parts, Rabdosia rubescens 23 parts, Herba Taraxaci 23 parts, Herba Kummerowiae Striatae 18 parts, Herba Diclipterae Chinensis 18 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, four
Blue or green 13 parts of season, Fructus Polygoni Orientalis 13 parts, Radix Cypripedii tibetici 8 parts, Polyporus 8 parts, Radix Aconiti Lateralis Preparata 8 parts, Ramulus Cinnamomi 4 parts, Herba Verbenae 4 parts, 4 parts, the Radix Euphorbiae Pekinensis, thousand
Gold 2 parts.
The preparation method of the Chinese medicine of above-mentioned preventing and treating contrast induced nephropathy, step is as follows:
Step one: said herbal medicine remove impurity be placed in marmite, adds the water soaking 50 minutes of raw material weight 6 times, then uses force
Fire decocts to boiling, uses slow fire instead and continues to decoct 35-45min, filters, leach medicinal residues, obtain decocting liquid first, then to filtering residue
The water of middle addition raw material weight 3 times, intense fire decocts to boiling, and slow fire continues to decoct 15min, filters, obtains secondary decocting liquid, closes
And twice decocting liquid, obtain filtrate；
Step 2: filtrate step one obtained is condensed into and surveys relative density at 60 DEG C is the clear paste of 1.2, adds ethanol to containing ethanol
Amount is 60%, then stirs evenly, and stands, and filters, takes filtrate recycling ethanol, is condensed into the extractum containing solid weight 66%, adds monosaccharide
Slurry 10%, refined honey 12%, sodium benzoate 2%, stock solution embedding, irradiation sterilization, packed products, obtain the present invention and prevent and treat contrast induced nephropathy
Chinese medicine.
Model case two: week xx, man, 48 years old.Patient checks because of Urinary tract anomalies row CTU, after the radiography same day and radiography
The continuous Chinese medicine giving the embodiment of the present invention 3 for two days, after radiography when the 3rd day, serum creatinine rises to the highest, rises than before radiography
High by 4%, after radiography the 6th day, serum creatinine recovered normal level to radiography, the clinical symptoms such as anuria, oliguria does not occurs in 7 days.
Embodiment 4 one kinds prevents and treats the Chinese medicine of contrast induced nephropathy, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from
(every part takes 1g): Radix Et Rhizoma Rhei 27 parts, Rabdosia rubescens 27 parts, Herba Taraxaci 27 parts, Herba Kummerowiae Striatae 22 parts, Herba Diclipterae Chinensis 22 parts, Radix Et Caulis Acanthopanacis Senticosi 22 parts, four
Blue or green 17 parts of season, Fructus Polygoni Orientalis 17 parts, Radix Cypripedii tibetici 12 parts, Polyporus 12 parts, Radix Aconiti Lateralis Preparata 12 parts, Ramulus Cinnamomi 6 parts, Herba Verbenae 6 parts, 6 parts, the Radix Euphorbiae Pekinensis,
Semen Euphorbiae 4 parts.
The preparation method of the Chinese medicine of above-mentioned preventing and treating contrast induced nephropathy, step is as follows:
Step one: said herbal medicine remove impurity be placed in marmite, adds the water soaking 60 minutes of raw material weight 8 times, then uses force
Fire decocts to boiling, uses slow fire instead and continues to decoct 40min, filters, leach medicinal residues, obtain decocting liquid first, then in filtering residue
Adding the water of raw material weight 5 times, intense fire decocts to boiling, and slow fire continues to decoct 20min, filters, obtains secondary decocting liquid, merges
Twice decocting liquid, obtains filtrate；
Step 2: filtrate step one obtained is condensed into and surveys relative density at 60 DEG C is the clear paste of 1.25, adds ethanol to containing second
Alcohol amount is 60%, then stirs evenly, and stands, and filters, takes filtrate recycling ethanol, is condensed into the extractum containing solid weight 67%, adds single
Syrup 10%, refined honey 12%, sorbic acid 2%, stock solution embedding, irradiation sterilization, packed products, obtain the present invention and prevent and treat contrast induced nephropathy
Chinese medicine.
Embodiment 5 one kinds prevents and treats the Chinese medicine of contrast induced nephropathy, takes off and states the raw material of Chinese medicine of weight proportion and be prepared from
(every part takes 1g): Radix Et Rhizoma Rhei 25 parts, Rabdosia rubescens 25 parts, Herba Taraxaci 25 parts, Herba Kummerowiae Striatae 20 parts, Herba Diclipterae Chinensis 20 parts, Radix Et Caulis Acanthopanacis Senticosi 20 parts, four
Blue or green 15 parts of season, Fructus Polygoni Orientalis 15 parts, Radix Cypripedii tibetici 10 parts, Polyporus 10 parts, Radix Aconiti Lateralis Preparata 10 parts, Ramulus Cinnamomi 5 parts, Herba Verbenae 5 parts, 5 parts, the Radix Euphorbiae Pekinensis,
Semen Euphorbiae 3 parts.
The preparation method of the Chinese medicine of above-mentioned preventing and treating contrast induced nephropathy, step is as follows:
Step one: said herbal medicine remove impurity be placed in marmite, adds the water soaking 60 minutes of raw material weight 8 times, then uses force
Fire decocts to boiling, uses slow fire instead and continues to decoct 40min, filters, leach medicinal residues, obtain decocting liquid first, then in filtering residue
Adding the water of raw material weight 5 times, intense fire decocts to boiling, and slow fire continues to decoct 20min, filters, obtains secondary decocting liquid, merges
Twice decocting liquid, obtains filtrate；
Step 2: filtrate step one obtained is condensed into and surveys relative density at 60 DEG C is the clear paste of 1.2, adds ethanol to containing ethanol
Amount is 60%, then stirs evenly, and stands, and filters, takes filtrate recycling ethanol, is condensed into the extractum containing solid weight 66%, adds monosaccharide
Slurry 10%, refined honey 12%, sodium benzoate and sorbic acid 2%, stock solution embedding, irradiation sterilization, packed products, obtain the present invention prevent and treat right
Chinese medicine than agent nephropathy.
Experimental example: 1, selection of clinical: in order to verify that the present invention prevents and treats the effect of the Chinese medicine of contrast induced nephropathy, we take out
Having taken 200 radiography patients and carried out controlling experiment, be equally divided into two groups, experimental group and matched group, two groups in age, clinical manifestation
Etc. aspect there was no significant difference through statistical analysis.
2, prevention and controls:
Matched group: after 5h and radiography, 5h gives 0.9% sodium chloride solution 1mL/kg.h intravenous injection aquation respectively and controls before radiography
Treat, and advise patient to drink more water.
Experimental group: the Chinese medicine of the embodiment of the present invention 5 be administered orally after the radiography same day and radiography for three days on end, every day 10mL,
And advise patient to drink more water.
3, curative effect situation criterion: 1 day, 2 days, 3 days, 5 days and 7 days before measuring respectively and recording radiography, after radiography
Serum creatinine numerical value, before and after radiography, serum creatinine situation of change is as standard.Effective: serum creatinine rises less than 10%, does not goes out
Existing oliguria, the clinical symptoms such as anuria；Effective: serum creatinine rises 10%-25%, oliguria, the clinical symptoms such as anuria does not has substantially；Nothing
Effect: serum creatinine rises more than or equal to 25%, with clinical symptoms such as oliguria, anurias.
Accurately the data of two groups of experiments are added up and mathematical analysis, obtain specific experiment result such as following table:
Clinical tests prove that, the total effective rate of Chinese medicine of the present invention preventing and treating contrast induced nephropathy is 95%, with intravenous injection aquation
Prevention effect compare, have with low cost, determined curative effect, the advantage having no side effect, can effectively prevent and treat contrast induced nephropathy.
Claims (8)
1. the Chinese medicine preventing and treating contrast induced nephropathy, it is characterised in that: take off state weight proportion raw material of Chinese medicine preparation and
Become: Radix Et Rhizoma Rhei 20-30 part, Rabdosia rubescens 20-30 part, Herba Taraxaci 20-30 part, Herba Kummerowiae Striatae 15-25 part, Herba Diclipterae Chinensis 15-25 part, Radix Et Caulis Acanthopanacis Senticosi
15-25 part, Ilex purpurea Hassk.[I.chinensis Sims 10-20 part, Fructus Polygoni Orientalis 10-20 part, Radix Cypripedii tibetici 5-15 part, Polyporus 5-15 part, Radix Aconiti Lateralis Preparata 5-15 part, Ramulus Cinnamomi
2-8 part, Herba Verbenae 2-8 part, Radix Euphorbiae Pekinensis 2-8 part, Semen Euphorbiae 1-5 part.
A kind of Chinese medicine preventing and treating contrast induced nephropathy the most according to claim 1, it is characterised in that: take following weight and join
The raw material of Chinese medicine of ratio is prepared from: Radix Et Rhizoma Rhei 23-27 part, Rabdosia rubescens 23-27 part, Herba Taraxaci 23-27 part, Herba Kummerowiae Striatae 18-22 part, Canis familiaris L.
Liver dish 18-22 part, Radix Et Caulis Acanthopanacis Senticosi 18-22 part, Ilex purpurea Hassk.[I.chinensis Sims 13-17 part, Fructus Polygoni Orientalis 13-17 part, Radix Cypripedii tibetici 8-12 part, Polyporus 8-12
Part, Radix Aconiti Lateralis Preparata 8-12 part, Ramulus Cinnamomi 4-6 part, Herba Verbenae 4-6 part, Radix Euphorbiae Pekinensis 4-6 part, Semen Euphorbiae 2-4 part.
A kind of Chinese medicine preventing and treating contrast induced nephropathy the most according to claim 1, it is characterised in that: take following weight and join
The raw material of Chinese medicine of ratio is prepared from: Radix Et Rhizoma Rhei 25 parts, Rabdosia rubescens 25 parts, Herba Taraxaci 25 parts, Herba Kummerowiae Striatae 20 parts, Herba Diclipterae Chinensis 20 parts, thorn
Slender acanthopanax 20 parts, Ilex purpurea Hassk.[I.chinensis Sims 15 parts, Fructus Polygoni Orientalis 15 parts, Radix Cypripedii tibetici 10 parts, Polyporus 10 parts, Radix Aconiti Lateralis Preparata 10 parts, Ramulus Cinnamomi 5 parts, Herba Verbenae 5
Part, 5 parts, the Radix Euphorbiae Pekinensis, Semen Euphorbiae 3 parts.
4. according to a kind of Chinese medicine preventing and treating contrast induced nephropathy described in any one of claim 1-3, it is characterised in that: described
The Chinese medicine of preventing and treating contrast induced nephropathy is Chinese medicine oral liquid.
5. the preparation method of the Chinese medicine of a preventing and treating contrast induced nephropathy according to claim 4, it is characterised in that: step
Rapid as follows:
Step one: said herbal medicine remove impurity be placed in marmite, adds water soaking 50-70 minute of raw material weight 6-10 times, so
After with high heat decoct to boiling after, use instead slow fire continue decoct 35-45min, filter, leach medicinal residues, obtain decocting liquid first, then
Adding the water of raw material weight 3-7 times in filtering residue, intense fire decocts to boiling, and slow fire continues to decoct 15-25min, filters, obtains
Secondary decocting liquid, merges twice decocting liquid, obtains filtrate；
Step 2: filtrate step one obtained is condensed into and surveys relative density at 60 DEG C is the clear paste of 1.15-1.25, adds ethanol extremely
It is 60% containing amount of alcohol, then stirs evenly, stand, filter, take filtrate recycling ethanol, be condensed into the extractum containing solid weight 65-67%,
Add simple syrup 10%, refined honey 12%, preservative 2%, stock solution embedding, irradiation sterilization, packed products, obtain the present invention and prevent and treat contrast
The Chinese medicine of agent nephropathy.
The preparation method of a kind of Chinese medicine preventing and treating contrast induced nephropathy the most according to claim 5, it is characterised in that: step
Add the water soaking 60 minutes of raw material weight 8 times in rapid one, decoct to boiling the most with high heat, use slow fire instead and continue to decoct
40min, filters, leaches medicinal residues, obtains decocting liquid first, then adds the water of raw material weight 5 times in filtering residue, and intense fire decocts to boiling
After rising, slow fire continues to decoct 20min, filters, obtains secondary decocting liquid.
The preparation method of a kind of Chinese medicine preventing and treating contrast induced nephropathy the most according to claim 5, it is characterised in that: step
The filtrate that step one obtains being condensed in rapid two and surveying relative density at 60 DEG C is the clear paste of 1.2, adds ethanol to containing amount of alcohol being
60%, then stir evenly, stand, filter, take filtrate recycling ethanol, be condensed into the extractum containing solid weight 66%.
The preparation method of a kind of Chinese medicine preventing and treating contrast induced nephropathy the most according to claim 5, it is characterised in that: institute
Stating preservative is one or both in sodium benzoate, sorbic acid.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108379391A (en) * | 2018-05-28 | 2018-08-10 | 暨南大学附属第医院（广州华侨医院） | A kind of pharmaceutical composition and preparation method and application for treating nausea and vomiting after radiography |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547536A (en) * | 2015-02-05 | 2015-04-29 | 潍坊医学院 | Traditional Chinese medicine preparation for treating contrast-induced nephropathy |
| CN104887968A (en) * | 2015-06-16 | 2015-09-09 | 牛灵芝 | Traditional Chinese medicine preparation for preventing contrast associated nephropathy as well as preparation method |
-
2016
- 2016-06-29 CN CN201610492249.8A patent/CN105943863A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547536A (en) * | 2015-02-05 | 2015-04-29 | 潍坊医学院 | Traditional Chinese medicine preparation for treating contrast-induced nephropathy |
| CN104887968A (en) * | 2015-06-16 | 2015-09-09 | 牛灵芝 | Traditional Chinese medicine preparation for preventing contrast associated nephropathy as well as preparation method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108379391A (en) * | 2018-05-28 | 2018-08-10 | 暨南大学附属第医院（广州华侨医院） | A kind of pharmaceutical composition and preparation method and application for treating nausea and vomiting after radiography |
| CN108379391B (en) * | 2018-05-28 | 2021-01-22 | 暨南大学附属第一医院（广州华侨医院） | Pharmaceutical composition for treating nausea and vomiting after radiography and preparation method and application thereof |
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