CN103877356B - A kind of Chinese medicine preparation and preparation method for the treatment of myocardial infarction - Google Patents

A kind of Chinese medicine preparation and preparation method for the treatment of myocardial infarction Download PDF

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CN103877356B
CN103877356B CN201410136595.3A CN201410136595A CN103877356B CN 103877356 B CN103877356 B CN 103877356B CN 201410136595 A CN201410136595 A CN 201410136595A CN 103877356 B CN103877356 B CN 103877356B
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刘剑英
王志斌
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刘剑英
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Abstract

The invention discloses a kind of Chinese medicine preparation and preparation method for the treatment of myocardial infarction, belong to the field of Chinese medicines, the raw material of Chinese medicine preparation effective ingredient of the present invention consists of: Flos Hibisci Rosae-Sinensis, Bulbus Lilii, Caulis et Radix Tetrastigmatis Planicaulis, Radix Cudraniae, Herba sedi kamtschatici, Radix Clerodenri Cyrtophylli, Herba Violae, Clematis filamentosa Dunn, Rhizoma Paridis, Concha Meretricis seu Cyclinae, Herba Apii graveolentis, Bulbus Allii Macrostemonis, Flos Sophorae, Rhizoma alcasiae odorae, Caulis Spatholobi and Radix Sophorae Flavescentis, selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and it is suitable to have medical material compatibility selected by easypro Chinese medicine preparation of the present invention, meet Chinese medicine and pharmacy and modern medicine theory, and there is blood vessel of releiving, protection cardiac muscle, easing pain and diminishing inflammation, effect of benefiting QI and nourishing blood, to treatment myocardial infarction etc., there is significant curative effect, good absorbing effect, duration of efficacy is long, safe and reliable, advantage without any side effects, and taking convenience, with low cost, alleviate the financial burden of patient, can the clinical treatment of extensive use and myocardial infarction.

Description

A kind of Chinese medicine preparation and preparation method for the treatment of myocardial infarction
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation and preparation method for the treatment of myocardial infarction.
Background technology
Myocardial infarction is that coronary artery is acute, myocardial necrosis caused by persistence hypoxic-ischemic.Clinically have violent and lasting retrosternal pain more, has a rest and nitrate esters medicine can not complete incidence graph, increases and Progressive symmetric erythrokeratodermia ECG Change with serum enzyme activities, can complicated by arrhythmia, shock or heart failure, often can threat to life.Primary disease is the most common America and Europe, and the U.S. about has 1,500,000 people that myocardial infarction occurs every year.China, in recent years in obvious ascendant trend, newly sends to few 500,000 every year, existing trouble at least 200 ten thousand.
Patient is mostly occurred on coronary atherosclerosis basis, because some inducement causes Atherosclerotic Vessels: Changes Observed during Coronary to break, the platelet in blood is assembled in the plaque surface of breaking, and forms clot (thrombosis), unexpected blocked coronary arteries tube chamber, causes myocardial ischemia and necrosis; In addition, myocardial oxygen consumption acutely increases or coronary vasospasm also can bring out acute myocardial infarction, and common inducement is as follows:
1. overwork: overweight physical work, especially bear a heavy burden and step on building, excessive sports, continuous nervous fatigue etc., all can make heart burden, myocardium requirementing keto quantity increases suddenly, and the coronary artery of patients with coronary heart disease harden, narrow, can not fully expand and cause myocardial ischemia.Intense physical load also can bring out plaque rupture, causes acute myocardial infarction.
2. exciting: because the emotion changes of the fierceness such as exciting, nervous, angry brings out.
3. eating and drinking too much at one meal: after many myocardial infarction cases betide eating and drinking too much at one meal.Feed is a large amount of containing after the food of higher fatty acid high heat, and serum lipid concentrations raises suddenly, and cause blood stickiness to increase, Platelet increases.The basis of coronary stricture forms thrombosis, causes acute myocardial infarction.
4. cold stimulation: unexpected cold stimulation may bring out acute myocardial infarction.Therefore, patients with coronary heart disease will pay close attention to warming, and Winter-Spring cold season is one of reason that acute myocardial infarction is higher.
5. constipation: constipation is very common in the middle of old people.Clinically, cause the old people of myocardial infarction much because firmly holding one's breath during constipation.The attention that old people is enough must be caused, free movement of the bowels be kept.
6. smoking, heavy drinking: smoking and heavy drinking are by bringing out coronary vasospasm and myocardial oxygen consumption increases and brings out acute myocardial infarction.
At present, if the drug main for the treatment of myocardial infarction is based on western medicine, but Western medicine can only relief of symptoms, lacks means, easily recur pathology treatment.In nearly this year, although all attempt using Chinese medicine to treat myocardial infarction, all do not obtain larger development both at home and abroad, some Chinese medicine has certain curative effect to treatment myocardial infarction, but can not fully recover, and relapse rate is high; In order to work out a kind of medicine effectively treating myocardial infarction, various big hospital attracts great attention.
Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of myocardial infarction; Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable; meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of blood vessel of releiving, protection cardiac muscle, easing pain and diminishing inflammation, benefiting QI and nourishing blood, to treatment myocardial infarction etc., there is significant curative effect; good absorbing effect; duration of efficacy is long, safe and reliable, advantage without any side effects; and taking convenience; with low cost, alleviate the financial burden of patient, can the clinical treatment of extensive use and myocardial infarction.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for myocardial infarction, raw material composition and the parts by weight of making described Chinese medicine preparation are:
Flos Hibisci Rosae-Sinensis 35 ~ 58 portions of Bulbus Liliies 32 ~ 56 parts of Caulis et Radix Tetrastigmatis Planicaulis 31 ~ 55 parts of Radix Cudraniaes 28 ~ 52 parts
Herba sedi kamtschatici 28 ~ 52 parts of Radix Clerodenri Cyrtophyllis 26 ~ 48 portions of Herba Violaes 23 ~ 48 parts of Clematis filamentosa Dunn 21 ~ 45 parts
Rhizoma Paridis 20 ~ 44 parts of Concha Meretricis seu Cyclinaes 20 ~ 44 portions of Herba Apii graveolentis 19 ~ 43 parts of Bulbus Allii Macrostemonis 18 ~ 42 parts
Flos Sophorae 16 ~ 38 portions of Rhizoma alcasiae odoraes 16 ~ 34 portions of Caulis Spatholobis 14 ~ 32 parts of Radix Sophorae Flavescentiss 8 ~ 32 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation are:
Flos Hibisci Rosae-Sinensis 39 ~ 54 portions of Bulbus Liliies 36 ~ 52 parts of Caulis et Radix Tetrastigmatis Planicaulis 35 ~ 51 parts of Radix Cudraniaes 32 ~ 48 parts
Herba sedi kamtschatici 32 ~ 48 parts of Radix Clerodenri Cyrtophyllis 30 ~ 44 portions of Herba Violaes 27 ~ 43 parts of Clematis filamentosa Dunn 25 ~ 41 parts
Rhizoma Paridis 24 ~ 40 parts of Concha Meretricis seu Cyclinaes 24 ~ 40 portions of Herba Apii graveolentis 23 ~ 39 parts of Bulbus Allii Macrostemonis 22 ~ 38 parts
Flos Sophorae 20 ~ 34 portions of Rhizoma alcasiae odoraes 18 ~ 30 portions of Caulis Spatholobis 17 ~ 29 parts of Radix Sophorae Flavescentiss 12 ~ 28 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation are:
Flos Hibisci Rosae-Sinensis 43 ~ 50 portions of Bulbus Liliies 40 ~ 48 parts of Caulis et Radix Tetrastigmatis Planicaulis 39 ~ 47 parts of Radix Cudraniaes 36 ~ 44 parts
Herba sedi kamtschatici 36 ~ 44 parts of Radix Clerodenri Cyrtophyllis 34 ~ 41 portions of Herba Violaes 31 ~ 39 parts of Clematis filamentosa Dunn 29 ~ 37 parts
Rhizoma Paridis 28 ~ 36 parts of Concha Meretricis seu Cyclinaes 28 ~ 36 portions of Herba Apii graveolentis 27 ~ 35 parts of Bulbus Allii Macrostemonis 26 ~ 34 parts
Flos Sophorae 24 ~ 30 portions of Rhizoma alcasiae odoraes 21 ~ 27 portions of Caulis Spatholobis 20 ~ 26 parts of Radix Sophorae Flavescentiss 16 ~ 24 parts.
Raw material composition and the parts by weight of making described Chinese medicine preparation are:
Flos Hibisci Rosae-Sinensis 47 portions of Bulbus Liliies 44 parts of Caulis et Radix Tetrastigmatis Planicaulis 43 parts of Radix Cudraniaes 40 parts
Herba sedi kamtschatici 40 parts of Radix Clerodenri Cyrtophyllis 38 portions of Herba Violaes 35 parts of Clematis filamentosa Dunn 33 parts
Rhizoma Paridis 32 parts of Concha Meretricis seu Cyclinaes 32 portions of Herba Apii graveolentis 31 parts of Bulbus Allii Macrostemonis 30 parts
Flos Sophorae 27 portions of Rhizoma alcasiae odoraes 24 portions of Caulis Spatholobis 23 parts of Radix Sophorae Flavescentiss 20 parts.
Treat a preparation method for the Chinese medicine preparation of myocardial infarction, comprise following processing step:
(1) Flos Hibisci Rosae-Sinensis, Bulbus Lilii, Herba sedi kamtschatici, Radix Clerodenri Cyrtophylli, Clematis filamentosa Dunn, Rhizoma Paridis, Bulbus Allii Macrostemonis, Rhizoma alcasiae odorae and Radix Sophorae Flavescentis are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Caulis et Radix Tetrastigmatis Planicaulis, Radix Cudraniae and Caulis Spatholobi are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(3) Herba Violae and Herba Apii graveolentis are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) cleaned by Concha Meretricis seu Cyclinae, put and be popular in without pyrotechnics is calcined to, taking-up cools, and pulverizes, and it is for subsequent use that mistake 180 orders obtain fine powder;
(5) cleaned by Flos Sophorae, dry, put in pot, intense fire is fried to micro-Huang, and taking-up is ground into powder, crosses 160 orders and obtains fine powder, for subsequent use;
(6) by thick paste, juice and the fine powder mixing obtained by above-mentioned steps (1) ~ (5), make tablet, obtain the Chinese medicine preparation of described treatment myocardial infarction.
The property of medicine of the present invention's Chinese medicine used is as follows:
Flos Hibisci Rosae-Sinensis: sweet in the mouth, light, property is put down; GUIXIN, lung, liver, spleen channel.Removing heat from the lung and dissipating phlegm, removing pathogenic heat from blood and toxic substance from the body.Control phlegm-fire cough, epistaxis, dysentery, reddish and whitish turbid urine, carbuncle, skin infection." Luchuan book on Chinese herbal medicine " carries: " removing pathogenic heat from blood and toxic substance from the body.Control heat in blood, epistaxis, pruritus, skin infection.”
Bulbus Lilii: sweet in the mouth, micro-hardship, property is put down; Enter lung, the heart, gallbladder three warp.Nourishing the lung to arrest cough, clearing away heart-fire for tranquillization.Cure mainly lung expense chronic cough, cough and spit expectorant blood, after calentura, waste heat comes clear, and fidgets due to deficiency is palpitated with fear, staring spells, beriberi edema." property of medicine opinion " carries: " except spasm in the epigastrium, completely, bitterly, control beriberi, heat syndrome cough is inverse.”
Caulis et Radix Tetrastigmatis Planicaulis: sour in the mouth, puckery, warm in nature; GUIXIN, Liver Channel.To dispel the wind removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.Cure mainly rheumatic arthralgia, lumbar muscle strain, apoplectic hemiplegia, traumatic injury.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " dispeiling pathogenic wind and removing dampness.Treating rheumatic lumbago and skelalgia, hemiplegia, rheumatism of muscles pain.”
Radix Cudraniae: lightly seasoned, micro-hardship, cool in nature.Dispelling wind and removing obstruction in the collateral, removing damp-heat, removing toxic substances and promoting subsidence of swelling.Cure mainly rheumatic arthralgia, traumatic injury, yellow cellulitis, parotitis, pulmonary tuberculosis, gastric duodenal ulcer, stranguria with turbid discharge, distention of the abdomen caused by various parasites, amenorrhea, impairment caused by overstrain hemoptysis, treat carbuncle sore and swell.Modern medicine study confirms, Radix Cudraniae root ethanol extraction has good anti-tubercle bacillus effect.
Herba sedi kamtschatici: sour in the mouth, property is put down.Promoting blood circulation and hemostasis, mind calming dampness removing, subduing swelling and detoxicating.Control traumatic injury, hemoptysis, spit blood, have blood in stool, cardiopalmus, carbuncle." Fujian traditional herbal medicine " carries: " subduing the hyperfunction of the liver mind calming, clearing away heat from blood treat cardiopalmus.”
Radix Clerodenri Cyrtophylli: bitter in the mouth, cold in nature; GUIXIN, Liver Channel.Heat clearing away, removing toxic substances, removing heat from blood.Cure mainly encephalitis b, epidemic encephalitis, the high heat of flu, epidemic encephalitis, parotitis, heat in blood sends out class, measles pneumonia, and icteric tripe is scorching, diarrhea of heat type hematodiarrhoea, beriberoid pyretic arthralgia, headache, laryngopharynx swelling and pain, acute toothache, orchitis.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " dissipating blood stasis stops blooding for clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body.Control enteritis, bacillary dysentery, pharyngolaryngitis, tonsillitis, parotitis, cold, fever, gingiva bleeding gingival hemorrhage.”
Herba Violae: bitter in the mouth, cold in nature; GUIXIN, liver, spleen channel.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Cure mainly furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " removing blood stasis separates carbuncle mange, nine kinds of hemorrhoid, all sore diseases.”
Clematis filamentosa Dunn: bitter in the mouth, slightly cool in nature; GUIXIN, Liver Channel.Sedation and analgesia, clearing away liver-fire, mind calming god, blood pressure lowering, removing obstruction in the collateral to relieve pain.Cure mainly hypertension, insomnia, headache, numb limbs and tense tendons, wind-heat of liver channel, conjunctival congestion and swelling pain, acute toothache, rheumatic arthralgia.Modern medicine study confirms, Clematis filamentosa Dunn is to the symptom improved caused by hypertension, as headache, giddy, feeling of fullness in the head, numb limbs and tense tendons, insomnia etc. have good curative effect, preliminary observation all has therapeutical effect to the hemiplegic patient caused patients with coronary heart disease and cerebrovas-cularaccident simultaneously.
Rhizoma Paridis: bitter in the mouth, cool in nature, mild toxicity; GUIXIN, liver, lung, stomach, large intestine channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Cure mainly carbuncle sore tumefacting virus, pharyngeal swelling sore throat, acute mastitis, snake bite and insect sting, traumatic pain, liver-heat is twitched.Modern medicine study confirms, Rhizoma Paridis has good result to woman's galactostasis of managing property.
Concha Meretricis seu Cyclinae: salty in the mouth, property is put down; Enter the heart, kidney two warp.Clearing away heat and promoting diuresis, resolving phlegm and softening hard masses.Cure mainly heat-phlegm to breathe heavily and cough, edema, gonorrhea, wart, tumor are gathered, blood agglomeration chest pain, dysentery, hemorrhoid, metrorrhagia, leukorrhagia." herbal classic " carries: " main cough with dyspnea, pants, stuffy sensation with restlessness, chest pain cold and heat.”
Herba Apii graveolentis: taste is cool, sweet, property is pungent; Enter liver, gallbladder, pericardium channel.Clearing away heat-damp and promoting diuresis, suppressing the hyperactive liver stomach invigorating, removing heat from the liver, nourishes blood." health communication " carries: " heat is washed in clearing stomach, promoting blood circulation, and tasty and refreshing tooth wets one's whistle, improving eyesight stuffy nose relieving, refreshment stomach invigorating, nourishing the lung to arrest cough." modern medicine study confirmation, it is also many that Herba Apii graveolentis contains the content of mineral substances such as abundant vitamin A, vitamin B1, vitamin B2, vitamin C and Citrin, calcium, ferrum, phosphorus, also has the compositions such as protein, mannitol and dietary fiber in addition; In addition, Herba Apii graveolentis also has clearing away stomach-heat, promoting blood circulation, strong tooth wets one's whistle, improving eyesight refreshment, nourishing the lung to arrest cough effect.
Bulbus Allii Macrostemonis: acrid in the mouth, hardship, warm in nature; Return lung, the heart, stomach, large intestine channel.Activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.Cure mainly the thorough back of the body of obstruction of qi in the chest and cardialgia, breast gastral cavity painful abdominal mass is vexed, cough with asthma abundant expectoration, epigastric pain, heavy after letting out dysentery, leucorrhea, furuncle carbuncle." detailed outline " carries: " control SHAO YIN syndrome to faint and inverse let out dysentery, and thoracic obstruction twinge, the therapeutic method to keep the adverse QI flowing downwards is fallen apart blood, antiabortive.Temperature compensation is supporing yang road.”
Flos Sophorae: bitter in the mouth, cold nature; Enter liver, lung, the heart, large intestine channel.Cooling blood for hemostasis, liver heat removing and eyesight improving.Cure mainly discharging fresh blood stool, hemorrhoid hematochezia, dysentery, hematuria, stranguria with blood, metrorrhagia, spit blood, epistaxis, liver-heat is had a headache, conjunctival congestion and swelling pain, carbuncle skin infection." book on Chinese herbal medicine just " carries: " cool large intestine kills infantile malnutrition worm.Control skin sore, erosion of vulva pruritus due to damp pathogen, anal fistula, separate Fructus Myricae rubrae malignant boil, primary sore volt poison." modern medicine study confirms, the globulariacitrin contained by Flos Sophorae can strengthen capillary resistance, improves blood vessel wall fragility, reduces blood pressure, edema, hypertension is had to the effect preventing rupture of blood vessel in brain, also has antiinflammatory action in addition.
Rhizoma alcasiae odorae: taste is micro-pungent, puckery, cold in nature, poisonous; GUIXIN, liver, gallbladder, large intestine channel.Heat-clearing and toxic substances removing, promoting the circulation of QI to relieve pain, mass dissipating and swelling eliminating.Cure mainly influenza, flu, stomachache, pulmonary tuberculosis, rheumatic ostalgia, furuncle, swollen ulcer drug, scrofula, attached bone carbuncle, class is bald, scabies, worm venom.
Caulis Spatholobi: bitter in the mouth, micro-sweet, warm in nature; Return liver, the heart, kidney channel.Relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation.Cure mainly rheumatic arthralgia, numb hand and foot, quadriplegia, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature; Return liver, kidney, large intestine, small intestinal, the heart, urinary bladder channel.Heat clearing away is dry, parasite killing diuresis.Be widely used in multiple humidifier fever, as damp-heat dysentery; External can decoct soup washout, for hemorrhoid, and women gynecological.Modern medicine study confirms, Radix Sophorae Flavescentis ether extract and ethanol extract have stronger bacteriostasis to staphylococcus aureus, and Radix Sophorae Flavescentis water logging agent has inhibitory action to trichophyton, Trichophyton concentricunm, trichophyton, Du's big belly difficult to understand little spore tinea bacterium etc.
The present invention compared with prior art, has following beneficial effect:
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable; meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of blood vessel of releiving, protection cardiac muscle, easing pain and diminishing inflammation, benefiting QI and nourishing blood, to treatment myocardial infarction etc., there is significant curative effect; good absorbing effect; duration of efficacy is long, safe and reliable, advantage without any side effects; and taking convenience; with low cost, alleviate the financial burden of patient, can the clinical treatment of extensive use and myocardial infarction.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation of the present invention and weight are:
Flos Hibisci Rosae-Sinensis 54g Bulbus Lilii 52g Caulis et Radix Tetrastigmatis Planicaulis 51g Radix Cudraniae 48g
Herba sedi kamtschatici 48g Radix Clerodenri Cyrtophylli 44g Herba Violae 43g Clematis filamentosa Dunn 41g
Rhizoma Paridis 40g Concha Meretricis seu Cyclinae 40g Herba Apii graveolentis 39g Bulbus Allii Macrostemonis 38g
Flos Sophorae 34g Rhizoma alcasiae odorae 30g Caulis Spatholobi 29g Radix Sophorae Flavescentis 28g.
The preparation method of Chinese medicine preparation of the present invention, comprises following processing step:
(1) Flos Hibisci Rosae-Sinensis, Bulbus Lilii, Herba sedi kamtschatici, Radix Clerodenri Cyrtophylli, Clematis filamentosa Dunn, Rhizoma Paridis, Bulbus Allii Macrostemonis, Rhizoma alcasiae odorae and Radix Sophorae Flavescentis are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Caulis et Radix Tetrastigmatis Planicaulis, Radix Cudraniae and Caulis Spatholobi are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(3) Herba Violae and Herba Apii graveolentis are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) cleaned by Concha Meretricis seu Cyclinae, put and be popular in without pyrotechnics is calcined to, taking-up cools, and pulverizes, and it is for subsequent use that mistake 180 orders obtain fine powder;
(5) cleaned by Flos Sophorae, dry, put in pot, intense fire is fried to micro-Huang, and taking-up is ground into powder, crosses 160 orders and obtains fine powder, for subsequent use;
(6) by thick paste, juice and the fine powder mixing obtained by above-mentioned steps (1) ~ (5), make tablet, obtain the Chinese medicine preparation of described treatment myocardial infarction.
Usage and dosage: oral or buccal, every day 3 times, each 1 time of morning, noon and afternoon, each 1 (every sheet 0.5g), within 16 days, be 1 course for the treatment of, 2 ~ 4 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese medicine preparation of the present invention and weight are:
Flos Hibisci Rosae-Sinensis 50g Bulbus Lilii 48g Caulis et Radix Tetrastigmatis Planicaulis 47g Radix Cudraniae 44g
Herba sedi kamtschatici 44g Radix Clerodenri Cyrtophylli 41g Herba Violae 39g Clematis filamentosa Dunn 37g
Rhizoma Paridis 36g Concha Meretricis seu Cyclinae 36g Herba Apii graveolentis 35g Bulbus Allii Macrostemonis 34g
Flos Sophorae 30g Rhizoma alcasiae odorae 27g Caulis Spatholobi 26g Radix Sophorae Flavescentis 24g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicine preparation of the present invention and weight are:
Flos Hibisci Rosae-Sinensis 47g Bulbus Lilii 44g Caulis et Radix Tetrastigmatis Planicaulis 43g Radix Cudraniae 40g
Herba sedi kamtschatici 40g Radix Clerodenri Cyrtophylli 38g Herba Violae 35g Clematis filamentosa Dunn 33g
Rhizoma Paridis 32g Concha Meretricis seu Cyclinae 32g Herba Apii graveolentis 31g Bulbus Allii Macrostemonis 30g
Flos Sophorae 27g Rhizoma alcasiae odorae 24g Caulis Spatholobi 23g Radix Sophorae Flavescentis 20g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicine preparation of the present invention and weight are:
Flos Hibisci Rosae-Sinensis 43g Bulbus Lilii 40g Caulis et Radix Tetrastigmatis Planicaulis 39g Radix Cudraniae 36g
Herba sedi kamtschatici 36g Radix Clerodenri Cyrtophylli 34g Herba Violae 31g Clematis filamentosa Dunn 29g
Rhizoma Paridis 28g Concha Meretricis seu Cyclinae 28g Herba Apii graveolentis 27g Bulbus Allii Macrostemonis 26g
Flos Sophorae 24g Rhizoma alcasiae odorae 21g Caulis Spatholobi 20g Radix Sophorae Flavescentis 16g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of Chinese medicine preparation of the present invention and weight are:
Flos Hibisci Rosae-Sinensis 39g Bulbus Lilii 36g Caulis et Radix Tetrastigmatis Planicaulis 35g Radix Cudraniae 32g
Herba sedi kamtschatici 32g Radix Clerodenri Cyrtophylli 30g Herba Violae 27g Clematis filamentosa Dunn 25g
Rhizoma Paridis 24g Concha Meretricis seu Cyclinae 24g Herba Apii graveolentis 23g Bulbus Allii Macrostemonis 22g
Flos Sophorae 20g Rhizoma alcasiae odorae 18g Caulis Spatholobi 17g Radix Sophorae Flavescentis 12g.
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of myocardial infarction, select the routine clinical observation of myocardial infarction patient 182 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 91 example, wherein male 46 example, women 45 example, 40 ~ 79 years old age, 59.5 years old mean age, the course of disease 1 ~ 5 year; Matched group 91 example, wherein male 45 example, women 46 example, 41 ~ 78 years old age, 59.5 years old mean age, the course of disease 1 ~ 4 year.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes Chinese medicine preparation of the present invention, oral or buccal, every day 3 times, each 1 time of morning, noon and afternoon, each 1 (every sheet 0.5g), and within 16 days, be 1 course for the treatment of, 2 ~ 4 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes clopidogrel bisulfate tablet, oral, also can take separately with food with clothes, and once a day, each a slice, the course for the treatment of is depending on the state of an illness.
3, efficacy determination:
(1) cure: body constitution strengthens, and angor uncomfortable in chest obviously disappears, and Electrocardioscopy is without exception.
(2) effective: body constitution obviously strengthens, angor uncomfortable in chest is obviously alleviated.
(3) effective: body constitution strengthens to some extent, angor uncomfortable in chest is alleviated to some extent.
(4) invalid: unchanged by treating rear clinical symptoms.
4, result:
Select in the treatment group of medicine of the present invention, cure 41 examples, effective 21 examples, effective 17 examples, invalid 12 examples, cure rate 45.1%, total effective rate 86.8%.
11 examples are cured, effective 19 examples, effective 27 examples, invalid 34 examples, cure rate 12.1%, total effective rate 62.6% in matched group.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Zeng, man, 48 years old, Jinan, Shandong Province people.Patient suffers from diabetes, and with symptoms such as arrhythmia, dizziness headache, insomnia, asthma uncomfortable in chest, obvious deficiency myocardial blood supply, take Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom disappears substantially, after taking the 2nd course for the treatment of, symptom disappears completely, normal ECG, follows up a case by regular visits to and does not recur for 1 year.
2, Guo, female, 55 years old, people from Wuhan, Hubei.Patient suffers from hypertension, diabetes, cardiac blood supply deficiency disease for many years, though through multi-treatment, and poor effect.To our hospital afterwards, after taking 1 course for the treatment of of Chinese medicine preparation of the present invention, on inspection, the related index such as whole blood viscosity, plasma viscosity and myocardial infarction attack times have remarkable improvement, after taking 2 courses for the treatment of of Chinese medicine preparation of the present invention again, clinical symptoms disappears substantially on inspection, and indices reaches normal range substantially, follows up a case by regular visits to without recurrence after 2 years.
3, Peng, man, 62 years old, people from Changsha.Patient's readme one day excited burst precordialgia of cause, sometimes in vexed distending pain, speed comes my institute, and through looking into myocardial infarction, take Chinese medicine preparation of the present invention treatment, after taking 2 courses for the treatment of, symptom all disappears, and the no positive sign of whole body can be looked into, and follows up a case by regular visits to 1 year without recurrence.
4, Hao, female, 67 years old, Zhengzhou, henan people.Have palpitation after patient's fatigue, dyspnea, suffer from hypertension, hyperlipidemia is had a surplus for 5 years, through Electrocardioscopy display myocardial ischemia, coronarography display sclerosis, show that patient suffers from coronary heart disease according to clinical symptoms diagnosis, myocardial ischemia, after taking 1 course for the treatment of of Chinese medicine preparation of the present invention, blood pressure, blood fat are steady, nervous, dyspnea symptom is eliminated, after taking 1 course for the treatment of of Chinese medicine preparation of the present invention again, Electrocardioscopy display cardiac muscle no longer ischemia, coronarography display sclerosis is eliminated, pay a return visit, the state of an illness does not recur so far.
5, certain is gone into business, man, 69 years old, people from Suzhou, Anhui.Patient suffers from coronary disease, myocardial infarction, gas is not carried out often, dizzy insomnia, and suffer from prostatitis, hypertension, arrhythmia, after taking 1 course for the treatment of of Chinese medicine preparation of the present invention, dizzy insomnia, arrhythmia symptom are clearly better, dizzy insomnia, arrhythmia transference cure after taking 2 courses for the treatment of, physical recovery is normal on inspection, follows up a case by regular visits to and does not recur so far.
6, Ma, female, 71 years old, jiangsu wuxi people.Coronary artery disease for many years, feel oppressed by midnight, on do not carry out gas, arrhythmia, sensation of oppression over the chest with shortness of breath, frequent night sweat, numb limbs and tense tendons.To our hospital, Electrocardioscopy finds that there is transient myocardial infarction phenomenon, takes Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom is obviously improved, after taking the 2nd course for the treatment of, and recovery from illness, general malaise transference cure, Electrocardioscopy is normal, follows up a case by regular visits to and does not recur for 3 years.

Claims (5)

1. treat a Chinese medicine preparation for myocardial infarction, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are:
Flos Hibisci Rosae-Sinensis 35 ~ 58 portions of Bulbus Liliies 32 ~ 56 parts of Caulis et Radix Tetrastigmatis Planicaulis 31 ~ 55 parts of Radix Cudraniaes 28 ~ 52 parts
Herba sedi kamtschatici 28 ~ 52 parts of Radix Clerodenri Cyrtophyllis 26 ~ 48 portions of Herba Violaes 23 ~ 48 parts of Clematis filamentosa Dunn 21 ~ 45 parts
Rhizoma Paridis 20 ~ 44 parts of Concha Meretricis seu Cyclinaes 20 ~ 44 portions of Herba Apii graveolentis 19 ~ 43 parts of Bulbus Allii Macrostemonis 18 ~ 42 parts
Flos Sophorae 16 ~ 38 portions of Rhizoma alcasiae odoraes 16 ~ 34 portions of Caulis Spatholobis 14 ~ 32 parts of Radix Sophorae Flavescentiss 8 ~ 32 parts.
2. a kind of Chinese medicine preparation for the treatment of myocardial infarction according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are:
Flos Hibisci Rosae-Sinensis 39 ~ 54 portions of Bulbus Liliies 36 ~ 52 parts of Caulis et Radix Tetrastigmatis Planicaulis 35 ~ 51 parts of Radix Cudraniaes 32 ~ 48 parts
Herba sedi kamtschatici 32 ~ 48 parts of Radix Clerodenri Cyrtophyllis 30 ~ 44 portions of Herba Violaes 27 ~ 43 parts of Clematis filamentosa Dunn 25 ~ 41 parts
Rhizoma Paridis 24 ~ 40 parts of Concha Meretricis seu Cyclinaes 24 ~ 40 portions of Herba Apii graveolentis 23 ~ 39 parts of Bulbus Allii Macrostemonis 22 ~ 38 parts
Flos Sophorae 20 ~ 34 portions of Rhizoma alcasiae odoraes 18 ~ 30 portions of Caulis Spatholobis 17 ~ 29 parts of Radix Sophorae Flavescentiss 12 ~ 28 parts.
3. a kind of Chinese medicine preparation for the treatment of myocardial infarction according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are:
Flos Hibisci Rosae-Sinensis 43 ~ 50 portions of Bulbus Liliies 40 ~ 48 parts of Caulis et Radix Tetrastigmatis Planicaulis 39 ~ 47 parts of Radix Cudraniaes 36 ~ 44 parts
Herba sedi kamtschatici 36 ~ 44 parts of Radix Clerodenri Cyrtophyllis 34 ~ 41 portions of Herba Violaes 31 ~ 39 parts of Clematis filamentosa Dunn 29 ~ 37 parts
Rhizoma Paridis 28 ~ 36 parts of Concha Meretricis seu Cyclinaes 28 ~ 36 portions of Herba Apii graveolentis 27 ~ 35 parts of Bulbus Allii Macrostemonis 26 ~ 34 parts
Flos Sophorae 24 ~ 30 portions of Rhizoma alcasiae odoraes 21 ~ 27 portions of Caulis Spatholobis 20 ~ 26 parts of Radix Sophorae Flavescentiss 16 ~ 24 parts.
4. a kind of Chinese medicine preparation for the treatment of myocardial infarction according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation are:
Flos Hibisci Rosae-Sinensis 47 portions of Bulbus Liliies 44 parts of Caulis et Radix Tetrastigmatis Planicaulis 43 parts of Radix Cudraniaes 40 parts
Herba sedi kamtschatici 40 parts of Radix Clerodenri Cyrtophyllis 38 portions of Herba Violaes 35 parts of Clematis filamentosa Dunn 33 parts
Rhizoma Paridis 32 parts of Concha Meretricis seu Cyclinaes 32 portions of Herba Apii graveolentis 31 parts of Bulbus Allii Macrostemonis 30 parts
Flos Sophorae 27 portions of Rhizoma alcasiae odoraes 24 portions of Caulis Spatholobis 23 parts of Radix Sophorae Flavescentiss 20 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for the Chinese medicine preparation of myocardial infarction, it is characterized in that: comprise following processing step:
(1) Flos Hibisci Rosae-Sinensis, Bulbus Lilii, Herba sedi kamtschatici, Radix Clerodenri Cyrtophylli, Clematis filamentosa Dunn, Rhizoma Paridis, Bulbus Allii Macrostemonis, Rhizoma alcasiae odorae and Radix Sophorae Flavescentis are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Caulis et Radix Tetrastigmatis Planicaulis, Radix Cudraniae and Caulis Spatholobi are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(3) Herba Violae and Herba Apii graveolentis are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) cleaned by Concha Meretricis seu Cyclinae, put and be popular in without pyrotechnics is calcined to, taking-up cools, and pulverizes, and it is for subsequent use that mistake 180 orders obtain fine powder;
(5) cleaned by Flos Sophorae, dry, put in pot, intense fire is fried to micro-Huang, and taking-up is ground into powder, crosses 160 orders and obtains fine powder, for subsequent use;
(6) by thick paste, juice and the fine powder mixing obtained by above-mentioned steps (1) ~ (5), make tablet, obtain the Chinese medicine preparation of described treatment myocardial infarction.
CN201410136595.3A 2014-04-05 2014-04-05 A kind of Chinese medicine preparation and preparation method for the treatment of myocardial infarction Expired - Fee Related CN103877356B (en)

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Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
中医药治疗心系疾病汇讲;杨建宁等;《中国中医药现代远程教育》;20111231;第9卷(第24期);第66页第1.2.2节,第1.2.3节 *
小陷胸汤方证临床文献研究;王惠君等;《湖南中医杂志》;20080331;第24卷(第2期);83-86 *
当代名老中医治疗心肌梗死经验总结;郑丽等;《北京中医》;20070430;第26卷(第4期);221-223 *
温阳解毒活血法对急性心肌梗死患者的临床干预作用;洪永敦等;《广州中医药大学学报》;20120930;第29卷(第5期);519-522 *

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