CN105770152A - Pharmaceutic preparation for treating acute eczema and application thereof - Google Patents
Pharmaceutic preparation for treating acute eczema and application thereof Download PDFInfo
- Publication number
- CN105770152A CN105770152A CN201610257383.XA CN201610257383A CN105770152A CN 105770152 A CN105770152 A CN 105770152A CN 201610257383 A CN201610257383 A CN 201610257383A CN 105770152 A CN105770152 A CN 105770152A
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Abstract
The invention relates to a pharmaceutic preparation for treating acute eczema and application thereof. The pharmaceutic preparation is prepared from the following components in parts by weight: 20 to 30 parts of folium mori, 8 to 15 parts of cortex phellodendri, 10 to 30 parts of cortex dictamni, 8 to 16 parts of selfheal, 4 to 12 parts of liquorice, 10 to 15 parts of dandelion, 20 to 30 parts of white atractylodes rhizome, 10 to 19 parts of cooked panax notoginseng, 5 to 11 parts of dalbergia odorifera, 11 to 17 parts of shepherd's purse, 5 to 11 parts of fermented soybeans, 7 to 12 parts of elsholtzia, 4 to 10 parts of lotus leaves and 7 to 12 parts of red lotuses. The pharmaceutic preparation is prepared from pure traditional Chinese medicines, has the effects of clearing away heat and toxin, relieving rheumatic pains, dissipating blood stasis, relieving itching and pain, diminishing inflammation, killing bacteria and eliminating swelling, can effectively treat acute eczema which is difficult to recur, and has no toxic or side effect. The product is for external application, so that the product permeates into the body through the skin, so as to enhance the treating effect and improve the curative effect, and is particularly suitable for babies or infants.
Description
Technical field
The invention belongs to field of medicaments, particularly relate to a kind of for pharmaceutical preparation treating acute eczema and application thereof.
Background technology
Along with environment inadaptable of the change of society environment, drinking water and contact skin, skin disease is continuously increased,
Eczema is a kind of scytitis reaction of the acute pruritus caused by multiple internal and external factor.Divide three phases acute, subacute, chronic.
Acute stage tool oozes out tendency, and chronic phase then infiltrates, plump.Some patient directly translates into acute eczema.Skin lesion has multiform
Property, symmetry, pruritus and the easy feature such as recurrent exerbation.Eczematosis, because of complexity, is often internal and external reasons interaction result.Endogenous cause of ill
Such as chronic digestive system disease, psychentonia, insomnia, fatigue, emotion changes, endocrine disturbance, infection, the oldest
Dysbolismus etc., exopathogenic factor such as living environment, climate change, food etc. all can affect the generation of eczema.Environmental stimuli such as daylight,
Cold, dry, hot, hot water is scalded and various animal skin, plant, cosmetics, soap, staple fibre etc.
Induction.It it is a kind of delayed allergy that causes of the complicated inside and outside factor.
Acute eczema is a kind of common epidermis caused by multiple internal and external factor and the inflammatory dermatoses of high dermis. its feature
For conscious violent pruritus, skin lesion pleomorphism, symmetrical, have and ooze out tendency, the chronic course of disease, easy recurrent exerbation.Mostly occur
Child within 5 years old, is also found in adult, after infecting herpes simplex virus, about through 5-9 days incubation periods, and the highest heat
(39-40 DEG C), general malaise, Nausea and vomiting and the poisoning symptom such as drowsiness.Erythra starts from face, neck, upper limb and trunk
Etc. original dermatosis position, it is also possible to occur on normal skin.Lower limb are rare.Erythra feature: original erythra increases the weight of, prominent
Many intensive vesicles so occur, rapidly goes to pustule, there is omphalos on bleb top, base substrate is the redst and the most swollen.Sometimes erythra is fused into
Lamellar, after 1-2 week, erythra is dried incrustation, leaves over pigmentation and shallow cicatrix.Neighbouring lymphadenectasis.Can be concurrent
Pharyngitis, tonsillitis, rhinitis, otitis media, conjunctivitis, keratitis or corneal ulcer, pneumonia and encephalitis etc..
Eczematosis, because of complexity, treats still easily recurrent exerbation, difficult radical cure after taking a turn for the better.Because clinical form and position are respectively arranged with feature, therefore
Medication varies with each individual.General control principle find exactly may inducement, as working environment, living habit, diet, hobby,
Thought mood etc., and with or without chronic lesion and internal organs disease；Interior therapy selects antihistaminic antipruritic, and if desired two
Plant and coordinate or be used alternatingly.Universal eczema is orally available or injects glucocorticoid, but should not life-time service；Relatively common
It is exactly that Topical therapy selects appropriate dosage forms and medicine according to skin lesion situation.Acute eczema local physiological saline, 3% boric acid or 1:
2000-1:10000 potassium permanganate solution rinses, soak, Calamine Lotion convergence, protection.Subacute, acute eczema application
Suitably glucocorticoid cream, burnt oil-like formulations or immunomodulator, such as Tacrolimus paste, pimecrolimus ointment.Continue
Send out the infected's added with antibiotic preparation.
Preparation currently, with respect to acute eczema has had a lot, great many of experiments and clinical research prove Chinese medicine urticaria,
The dermatosiss such as pruritus, eczema, neurodermatitis, drug eruption have that curative effect is reliable, effect comprehensively, side effect is little, low price,
There is the advantage that Western medicine is incomparable.
Summary of the invention
For the defect of prior art, the present invention be directed to the present situation treated at present, it is provided that a kind of for treating acute eczema
Pharmaceutical preparation, and have no side effect, effective.
Specifically, the concrete scheme of the present invention is achieved in that
First, inventor according to drug matching experience provide a kind of treat acute eczema pharmaceutical preparation, prescription contains
Chinese medicine ingredients be: Folium Mori, Cortex Phellodendri, Cortex Dictamni, XIAKUQIU, Radix Glycyrrhizae, Herba Taraxaci, the Rhizoma Atractylodis Macrocephalae, cooked Radix Notoginseng, Lignum Dalbergiae Odoriferae, shepherd's purse
Dish, tasteless preserved soybean, Herba Moslae, Folium Nelumbinis, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.).
Further, inventor according to drug matching experience provide a kind of treat acute eczema pharmaceutical preparation, prescription each
Raw material dosage all has preferable curative effect, described formula and weight portion in the weight portion scope of the present invention: Folium Mori 20-30
Part, Cortex Phellodendri 8-15 part, Cortex Dictamni 10-30 part, XIAKUQIU 8-16 part, Radix Glycyrrhizae 4-12 part, Herba Taraxaci 10-15 part, the Rhizoma Atractylodis Macrocephalae
20-30 part, cooked Radix Notoginseng 10-19 part, Lignum Dalbergiae Odoriferae 5-11 part, Herba Capsellae 11-17 part, tasteless preserved soybean 5-11 part, Herba Moslae 7-12 part,
Folium Nelumbinis 4-10 part, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 7-12 part.
Carrying out preferably, reaching superior technique effect to the formula of above-mentioned weight portion, preferred formula is: 25 parts of Folium Mori,
Cortex Phellodendri 12 parts, Cortex Dictamni 20 parts, XIAKUQIU 12 parts, 8 parts of Radix Glycyrrhizae, Herba Taraxaci 12.5 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, cooked Radix Notoginseng
14.5 parts, Lignum Dalbergiae Odoriferae 8 parts, 14 parts of Herba Capsellae, tasteless preserved soybean 8 parts, Herba Moslae 10.5 parts, 7 parts of Folium Nelumbinis, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 9.5 parts.
Or:
26 parts of Folium Mori, Cortex Phellodendri 13 parts, Cortex Dictamni 19 parts, XIAKUQIU 13 parts, 9 parts of Radix Glycyrrhizae, Herba Taraxaci 13.5 parts, white
Art 24 parts, cooked Radix Notoginseng 14.5 parts, Lignum Dalbergiae Odoriferae 9 parts, 14 parts of Herba Capsellae, tasteless preserved soybean 9 parts, Herba Moslae 11.5 parts, 8 parts of Folium Nelumbinis,
Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 10.5 parts.
The pharmacological action of pharmaceutical preparation of the present invention is as follows:
Folium Mori: sweet in the mouth, cold in nature.
Gui Jing: return lung, Liver Channel.
Function cures mainly: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, for anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion
Dim-sighted.
Cortex Phellodendri: bitter in the mouth, cold in nature.
Gui Jing: return kidney, bladder warp.
Function cures mainly: heat clearing and damp drying, and pathogenic fire purging is except steaming, and detoxification sore treatment, for damp-heat dysentery, sore swollen toxin, eczema pruritus.
Cortex Dictamni: bitter in the mouth, cold in nature.
Gui Jing: return spleen, stomach, bladder warp.
Function cures mainly: heat clearing and damp drying, removing toxic substances of dispeling the wind.For damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, wind
Damp-heat arthralgia, jaundice dark coloured urine.
XIAKUQIU: bitter in the mouth, cold in nature.
Gui Jing: return liver, gallbladder meridian.
Function cures mainly: purging liver-fire, improving eyesight, mass dissipating and swelling eliminating, for conjunctival congestion and swelling pain, mesh pearl nyctalgia, and dizziness of having a headache, scrofula, wart
Tumor, acute mastitis, nodules of the breast, distending pain of the breast.
Radix Glycyrrhizae: sweet in the mouth, property is put down.
Gui Jing: enter spleen, stomach, the heart, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain.
Herba Taraxaci: bitter in the mouth, cold in nature.
Gui Jing: return liver, stomach warp.
Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia,
Lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, warm in nature.
Gui Jing: return spleen, stomach warp.
Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, water
Swollen, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Cooked Radix Notoginseng: sweet in the mouth, warm in nature.
Gui Jing: return liver, stomach warp.
Function cures mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen
Twinge, tumbling and swelling.
Lignum Dalbergiae Odoriferae: acrid in the mouth, warm in nature.
Gui Jing: return liver, spleen channel.
Effect: removing stasis to stop bleeding, regulating QI to relieve pain.For spitting blood, epistaxis, traumatic hemorrhage, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, fall and flutter wound
Bitterly, vomiting stomachache.
Herba Capsellae: sweet in the mouth, property is put down.
Function cures mainly: cooling blood for hemostasis, clearing away heat and promoting diuresis.For renal tuberculosis hematuria, puerperal metrorrhagia, menorrhagia, pulmonary tuberculosis is coughed up
Blood, hypertension, cold, fever, oedema due to nephritis, urinary system calculus, chyluria, enteritis
Tasteless preserved soybean: bitter in the mouth, pungent is cool.
Gui Jing: attach to the lung and stomach meridians.
Function cures mainly: induce sweat, relieving restlessness, and a surname sends out hot and suffocating.For catching a cold, cold and heat headache, fidgety uncomfortable in chest, restlessness of asrhenia type and insomnia.
Folium Nelumbinis: bitter in the mouth is flat.
Gui Jing: return liver, spleen, stomach warp.
Function cures mainly: clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.For summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood
Tell nosebleed, metrorrhagia of having blood in stool.Burnt FOLIUM NELUMBINIS astringent therapy removing stasis to stop bleeding.For multiple hemorrhage and puerperal blood faints.
Herba Moslae: Gui Jing: enter lung, stomach warp.
Effect: relieving the exterior syndrome by diaphoresis, removing dampness for regulating stomach, inducing diuresis to remove edema.Anemofrigid cold, edema tinea pedis.
Lagotis clarkei Hook. F (Lagotis brevituba Maxim.): bitter in the mouth, sweet, cold in nature.
Gui Jing: return lung, the heart, Liver Channel.
Function cures mainly: can heat clearing away, removing toxic substances, dampness removing, suppressing the hyperactive liver, promoting the circulation of blood, regulating menstruation；For excessive thirst of generating heat, cough due to lung-heat, have a headache dizzy
Dizzy, jaundice due to damp-heat, menoxenia, the diseases such as poisoning eaten by medicine..
In pharmaceutical preparation described above, the Chinese medicine used all uses its conventional medicinal part to be used as medicine, the Chinese medicine used
Rationally, all medicines have preferable effect for treatment acute eczema after share to amount.
The described pharmaceutical preparation for the treatment of acute eczema of the present invention, external preparation is made in wherein said pharmaceutical preparation, described
External preparation can be water decoction, ointment, gel etc. clinically can exterior-applied formulation, preferably water decoction, breast
Unguentum.
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) crude drug of formula ratio is put in appropriate pure water, after fast fire is fried open, then decoct slowly 20 minutes, pour out decocting
Liquid.
After the preparation of this water decoction, repeatable utilization is once, and temperature during use is 27-40 DEG C, one day potion.
According to the difference of patient, present invention also offers the preparation method of a kind of ointment treating eczema, by described crude drug
It is crushed and screened into powder or extracted prepared concentrated solution；2) in first step gained, add adjuvant, make ointment, the method
Comprise the steps:
1) Radix Glycyrrhizae, cooked Radix Notoginseng and Cortex Phellodendri are broken into fine powder and cross 80-100 mesh sieve；
2) by Ai Sangye, Cortex Dictamni, XIAKUQIU, Herba Taraxaci, the Rhizoma Atractylodis Macrocephalae, Lignum Dalbergiae Odoriferae, Herba Capsellae, tasteless preserved soybean, Herba Moslae, Folium Nelumbinis and Lagotis clarkei Hook. F (Lagotis brevituba Maxim.)
Roguing is cleaned, and intense fire is boiled, slow fire boiling 1.5h, decocts twice, merges decoction liquor, filters, and heating concentrates, and obtains concentration
Liquid；
3) by 1) fine powder and the step 2 of step) concentrated solution mix homogeneously, obtain mixture；
4) to 3) mixture of step adds pharmaceutically acceptable adjuvant, make ointment.
Above-mentioned steps 4) described in mixture be 1: 4-8 with pharmaceutically acceptable adjuvant weight consumption ratio, more preferably
1:4.7-6.5。
Pharmaceutically acceptable adjuvant of the present invention is selected from semi-synthetic fatty acid glyceride, Macrogol 4000, Polyethylene Glycol
400, one or more in Tween-80, polyoxyethylene, poloxamer, glycerin gelatine, glyceryl monostearate；More
More preferably mixture (semi-synthetic fatty acid glyceride and the list of semi-synthetic fatty acid glyceride and glyceryl monostearate
Tristerin weight consumption is than for 1:0.5).
The pharmaceutical preparation of the present invention purposes in preparation treatment eczema medicine, especially at preparation treatment acute eczema medicine
Purposes in thing, the using method water decoction of the present invention and ointment be used in combination best results, and the present invention is in treatment eczema
Therapeutic process in, use water decoction to clean affected part 2-3 time every day, and be coated with the ointment of the present invention, eczema is had significantly
Effect, just can significantly play in 3 days antipruritic, sterilization effect, within 7 days, have positive effect, eczema area greatly reduces,
Within 15 days, being almost recovered, effective percentage 100%, relapse rate is below 1%.
Compared with prior art, the present invention achieves significant advantage:
The present invention uses pure Chinese traditional medicine dispensing, has the effects such as heat-clearing and toxic substances removing, the dissipating blood stasis that dispels the wind, antipruritic pain relieving, anti-inflammation and sterilization, detumescence,
Can effectively treat eczema, and be difficult to recurrence, have no side effect, it is internal that this product is that therefore external preparation penetrates through skin, and enhancing is controlled
Treatment effect, improves curative effect, is especially suitable for the use of children's or baby.
Specific embodiment
It is obvious to a person skilled in the art that the invention is not restricted to the details of exemplary embodiment of the present invention, and without departing substantially from
In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from which
From the point of view of Dian, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by claims
Rather than described above limits, it is intended that all changes fallen in the implication of equivalency and scope of claim are included
In the present invention.
Embodiment 1: a kind of water decoction for treating acute eczema, concrete preparation method is:
20 grams of Folium Mori, Cortex Phellodendri 8 grams, Cortex Dictamni 10 grams, XIAKUQIU 8 grams, 4 grams of Radix Glycyrrhizae, Herba Taraxaci 10 grams, the Rhizoma Atractylodis Macrocephalae 20
Gram, cooked Radix Notoginseng 10 grams, Lignum Dalbergiae Odoriferae 5 grams, 11 grams of Herba Capsellae, tasteless preserved soybean 5 grams, Herba Moslae 7 grams, 4 grams of Folium Nelumbinis, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 7 grams.
Concrete preparation method is:
2) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) crude drug of formula ratio is put in appropriate pure water, after fast fire is fried open, then decoct slowly 20 minutes, pour out decocting
Liquid.
After the preparation of this water decoction, repeatable utilization is once, and temperature during use is 27-40 DEG C, one day potion.
Embodiment 2: a kind of water decoction for treating acute eczema, concrete preparation method is:
30 grams of Folium Mori, Cortex Phellodendri 15 grams, Cortex Dictamni 30 grams, XIAKUQIU 16 grams, 12 grams of Radix Glycyrrhizae, Herba Taraxaci 15 grams, white
Art 30 grams, cooked Radix Notoginseng 19 grams, Lignum Dalbergiae Odoriferae 11 grams, 17 grams of Herba Capsellae, tasteless preserved soybean 11 grams, Herba Moslae 12 grams, 10 grams of Folium Nelumbinis,
Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 12 grams.
Concrete preparation method is:
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) crude drug of formula ratio is put in appropriate pure water, after fast fire is fried open, then decoct slowly 20 minutes, pour out decocting
Liquid.
After the preparation of this water decoction, repeatable utilization is once, and temperature during use is 35-42 DEG C, one day potion.
Embodiment 3: a kind of water decoction for treating acute eczema, concrete preparation method is:
25 grams of Folium Mori, Cortex Phellodendri 12 grams, Cortex Dictamni 20 grams, XIAKUQIU 12 grams, 8 grams of Radix Glycyrrhizae, Herba Taraxaci 12.5 grams, white
Art 25 grams, cooked Radix Notoginseng 14.5 grams, Lignum Dalbergiae Odoriferae 8 grams, 14 grams of Herba Capsellae, tasteless preserved soybean 8 grams, Herba Moslae 10.5 grams, 7 grams of Folium Nelumbinis,
Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 9.5 grams.
Concrete preparation method is:
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) crude drug of formula ratio is put in appropriate pure water, after fast fire is fried open, then decoct slowly 20 minutes, pour out decocting
Liquid.
After the preparation of this water decoction, repeatable utilization is once, and temperature during use is 27-40 DEG C, one day potion.
Embodiment 4: a kind of water decoction for treating acute eczema, concrete preparation method is:
26 grams of Folium Mori, Cortex Phellodendri 13 grams, Cortex Dictamni 19 grams, XIAKUQIU 13 grams, 9 grams of Radix Glycyrrhizae, Herba Taraxaci 13.5 grams, white
Art 24 grams, cooked Radix Notoginseng 14.5 grams, Lignum Dalbergiae Odoriferae 9 grams, 14 grams of Herba Capsellae, tasteless preserved soybean 9 grams, Herba Moslae 11.5 grams, 8 grams of Folium Nelumbinis,
Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 10.5 grams.
Concrete preparation method is:
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) crude drug of formula ratio is put in appropriate pure water, after fast fire is fried open, then decoct slowly 20 minutes, pour out decocting
Liquid.
After the preparation of this water decoction, repeatable utilization is once, and temperature during use is 27-40 DEG C, one day potion.
Embodiment 5: a kind of ointment for treating acute eczema, concrete preparation method is:
20 grams of Folium Mori, Cortex Phellodendri 8 grams, Cortex Dictamni 10 grams, XIAKUQIU 8 grams, 4 grams of Radix Glycyrrhizae, Herba Taraxaci 10 grams, the Rhizoma Atractylodis Macrocephalae 20
Gram, cooked Radix Notoginseng 10 grams, Lignum Dalbergiae Odoriferae 5 grams, 11 grams of Herba Capsellae, tasteless preserved soybean 5 grams, Herba Moslae 7 grams, 4 grams of Folium Nelumbinis, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 7 grams.
Concrete preparation method is:
1) Radix Glycyrrhizae, cooked Radix Notoginseng and Cortex Phellodendri are broken into fine powder and cross 80-100 mesh sieve；
2) by Ai Sangye, Cortex Dictamni, XIAKUQIU, Herba Taraxaci, the Rhizoma Atractylodis Macrocephalae, Lignum Dalbergiae Odoriferae, Herba Capsellae, tasteless preserved soybean, Herba Moslae, Folium Nelumbinis and Lagotis clarkei Hook. F (Lagotis brevituba Maxim.)
Roguing is cleaned, and intense fire is boiled, slow fire boiling 1.5h, decocts twice, merges decoction liquor, filters, and heating concentrates, and obtains concentration
Liquid；
3) by 1) fine powder and 2 of step) the concentrated solution mix homogeneously of step, obtain mixed liquor；
4) to 3) mixed liquor of step adds appropriate semi-synthetic fatty acid glyceride, make ointment.
Embodiment 6: a kind of ointment for treating acute eczema, concrete preparation method is:
30 grams of Folium Mori, Cortex Phellodendri 15 grams, Cortex Dictamni 30 grams, XIAKUQIU 16 grams, 12 grams of Radix Glycyrrhizae, Herba Taraxaci 15 grams, white
Art 30 grams, cooked Radix Notoginseng 19 grams, Lignum Dalbergiae Odoriferae 11 grams, 17 grams of Herba Capsellae, tasteless preserved soybean 11 grams, Herba Moslae 12 grams, 10 grams of Folium Nelumbinis,
Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 12 grams.
Concrete preparation method is:
1) Radix Glycyrrhizae, cooked Radix Notoginseng and Cortex Phellodendri are broken into fine powder and cross 80-100 mesh sieve；
2) by Ai Sangye, Cortex Dictamni, XIAKUQIU, Herba Taraxaci, the Rhizoma Atractylodis Macrocephalae, Lignum Dalbergiae Odoriferae, Herba Capsellae, tasteless preserved soybean, Herba Moslae, Folium Nelumbinis and Lagotis clarkei Hook. F (Lagotis brevituba Maxim.)
Roguing is cleaned, and intense fire is boiled, slow fire boiling 1.5h, decocts twice, merges decoction liquor, filters, and heating concentrates, and obtains concentration
Liquid；
3) by 1) fine powder and 2 of step) the concentrated solution mix homogeneously of step, obtain mixed liquor；
4) to 3) mixed liquor of step adds appropriate semi-synthetic fatty acid glyceride, make ointment.
Embodiment 7: a kind of ointment for treating acute eczema, concrete preparation method is:
25 grams of Folium Mori, Cortex Phellodendri 12 grams, Cortex Dictamni 20 grams, XIAKUQIU 12 grams, 8 grams of Radix Glycyrrhizae, Herba Taraxaci 12.5 grams, white
Art 25 grams, cooked Radix Notoginseng 14.5 grams, Lignum Dalbergiae Odoriferae 8 grams, 14 grams of Herba Capsellae, tasteless preserved soybean 8 grams, Herba Moslae 10.5 grams, 7 grams of Folium Nelumbinis,
Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 9.5 grams.
Concrete preparation method is:
1) Radix Glycyrrhizae, cooked Radix Notoginseng and Cortex Phellodendri are broken into fine powder and cross 80-100 mesh sieve；
2) by Ai Sangye, Cortex Dictamni, XIAKUQIU, Herba Taraxaci, the Rhizoma Atractylodis Macrocephalae, Lignum Dalbergiae Odoriferae, Herba Capsellae, tasteless preserved soybean, Herba Moslae, Folium Nelumbinis and Lagotis clarkei Hook. F (Lagotis brevituba Maxim.)
Roguing is cleaned, and intense fire is boiled, slow fire boiling 1.5h, decocts twice, merges decoction liquor, filters, and heating concentrates, and obtains concentration
Liquid；
3) by 1) fine powder and 2 of step) the concentrated solution mix homogeneously of step, obtain mixed liquor；
4) to 3) mixed liquor of step adds the mixture (half of appropriate semi-synthetic fatty acid glyceride and glyceryl monostearate
Synthctic fat acid glyceride and glyceryl monostearate weight consumption are than for 1:0.5), make ointment.
Embodiment 8: a kind of ointment for treating acute eczema, concrete preparation method is:
26 grams of Folium Mori, Cortex Phellodendri 13 grams, Cortex Dictamni 19 grams, XIAKUQIU 13 grams, 9 grams of Radix Glycyrrhizae, Herba Taraxaci 13.5 grams, white
Art 24 grams, cooked Radix Notoginseng 14.5 grams, Lignum Dalbergiae Odoriferae 9 grams, 14 grams of Herba Capsellae, tasteless preserved soybean 9 grams, Herba Moslae 11.5 grams, 8 grams of Folium Nelumbinis,
Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 10.5 grams.
Concrete preparation method is:
1) Radix Glycyrrhizae, cooked Radix Notoginseng and Cortex Phellodendri are broken into fine powder and cross 80-100 mesh sieve；
2) by Ai Sangye, Cortex Dictamni, XIAKUQIU, Herba Taraxaci, the Rhizoma Atractylodis Macrocephalae, Lignum Dalbergiae Odoriferae, Herba Capsellae, tasteless preserved soybean, Herba Moslae, Folium Nelumbinis and Lagotis clarkei Hook. F (Lagotis brevituba Maxim.)
Roguing is cleaned, and intense fire is boiled, slow fire boiling 1.5h, decocts twice, merges decoction liquor, filters, and heating concentrates, and obtains concentration
Liquid；
3) by 1) fine powder and 2 of step) the concentrated solution mix homogeneously of step, obtain mixed liquor；
4) to 3) mixed liquor of step adds appropriate semi-synthetic fatty acid glyceride, make ointment.
Embodiment 9: acute skin irritation test
9.1, physical data
Big ear white race rabbit, 16, female, body weight 2.1-2.3kg；The ointment of embodiment 5-8.
9.2, test method:
The healthy family selecting skin intact exempts from 16, often group 4, is divided into A, B, C, D group, uses the breast of embodiment 5-8 respectively
Its spinal column both sides, back are cut by unguentum in test for first 24 hours by hair, remove the left and right each about 3cm × 3cm of gross area.During test
Take tested material 0.2ml to be applied on two layers of gauze of 2.5cm × 2.5cm, apply
Being affixed on skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Close 4 hours
After, dismantling, and go to remain tested material with warm water cleaning, the observations in 1,24 and 48 hours after removing tested material are smeared
Area skin reacts,
9.3, experimental result
There is not any erythema in laboratory animal skin, red and swollen, inflammation phenomenon.
Judging according to skin wound repair standards of grading in " disinfection technology standard " (2012), ointment of the present invention is to animal skin
Stimulus intensity belongs to nonirritant.
Embodiment 10: toxicology test:
10.1, physical data
Kunming mouse, 40, female, male half and half, body weight 18-22 gram；The water decoction of embodiment 1-4.
10.2, test method:
Select healthy adult mice 40, body weight 18-22 gram, female, male half and half, often group 10, is divided into A, B, C, D group, point
Not Shi Yong the water decoction of embodiment 1-4, dose design is female for 10ml/kg, and per os gavage gives tested material.Before gavage, animal is prohibited
Eat 12 hours, freely drink water.Give normal diet after gavage, observe two weeks, record poisoning symptom and death condition.
10.3, result of the test:
Within 14 day observation period, animal subject reaction without exception, without dead, postmortem no abnormality seen.According to " disinfection technology is advised
Model " acute toxicity grading criteria judges in (2012), water decoction of the present invention belongs to nontoxic level.
Embodiment 11: clinical trial
11.1, physical data
Patient medical because suffering from acute eczema during accepting in December, 2012 in December, 2015 for medical treatment, 300 examples, male 160
Example, 3 months-5 years old age, 1.4 years old mean age；Women 140 example, 3 months-5 years old age, 1.3 years old mean age.
Be randomly divided into 3 groups, respectively treatment group A group, treatment group B group, matched group, between three groups the factor such as the state of an illness, age without
Significant difference, has comparability.
11.1, Therapeutic Method
Treatment A group: of the ointment of the one+embodiment 7 that the water decoction of embodiment 3 is opened, water decoction is cooled to
35-42 DEG C, washout affected part 10-20min, appropriate ointment then it is coated with in affected part.Water decoction and ointment are 2 every day
Secondary, 1 course for the treatment of is 7 days.
Treatment B group: of the ointment of the one+embodiment 8 that the water decoction of embodiment 4 is opened, water decoction is cooled to
35-42 DEG C, washout affected part 10-20min, appropriate ointment then it is coated with in affected part.Water decoction and ointment are 2 every day
Secondary, 1 course for the treatment of is 7 days.
Matched group: use the clear ointment of appropriate noxious dampness to smear affected part, is 2 every day, and 1 course for the treatment of is 7 days.
11.2, efficacy assessment standard
Recovery from illness: eczema erythema disappears, and affected skin transfers to normally, kermesinus disappears.
Effective: eczema erythema significantly reduces, attack times reduces, and pruritus alleviates, and affected skin does not spreads or diffusion velocity subtracts
Slow.
Invalid: symptom does not disappear or increases the weight of.
Bounce-back: cure latter 3 months and run into hygrothermal environment and still show effect.
Effective percentage: (recovery from illness+take a turn for the better)/patient populations.
Rebound rate: (recovery from illness+take a turn for the better) recurrence/(recovery from illness+take a turn for the better).
11.3, criterion:
1, acute onset, skin lesion is made up of erythema, pimple, vesicle.Cluster slabbing, often cause because scratching erosion, ooze out,
Incrustation and suppuration etc. change, and blur margin is often symmetric.
2, play is itched.
Meeting above standard to be, acute eczema patient also includes in the present invention.
11.4, disease overall therapeutic result
Through the treatment of 2 courses for the treatment of, therapeutic outcome is as follows:
Table 1 treatment group and treatment of control group and the situation of the recurrence after 3 months
Note: compare with matched group group, * p < 0.05, * * represents p < 0.01；
As can be seen from Table 1: through the treatment of 2 courses for the treatment of, treatment group compares with matched group total effective rate, has significantly statistics
Learning difference (P < 0.05), the effective percentage for the treatment of group is 100%, and the effective percentage of matched group is 88%；Treatment group rebounds with matched group
Rate is compared, and has significant significant difference (P < 0.01), the rebound rate high nearly 61.4% of matched group, and western medicine
Having obvious dependency, therapeutic effect is significantly lower than treatment group.
11.5 model case:
Case 1: poplar, man 1 month, people from Suqian, Jiangsu, in December, 2013 is to our hospital, and patients head, health are each
Part has substantial amounts of erythema, concentrates on head, trunk, especially the most serious with head, it is difficult to falling asleep, ear clip both sides are also
Having a large amount of erythema, night cry sits up, and introduces through others, uses the embodiment of the present invention 3 water decoction to wash affected part, and embodiment 7
Ointment smears affected part, and after using 3 days, patient sleeps's mass is preferable, and after 1 course for the treatment of, the erythema overwhelming majority disappears, disease
Shape is wholly absent, and is continuing with 1 course for the treatment of, cures completely.Within 3 months, call-on back by phone does not recur.
Case 2: grandson, 2 years old sky of man, people from Linyi, Shandong, in August, 2013, I treated at institute, and patient has the wettest
Rash symptom, face and skin involve whole body, and household uses the medicine such as erythromycin ointment, Aloe glue, poor effect, is situated between through people
Continue my institute's treatment, uses the embodiment of the present invention to use the embodiment of the present invention 4 water decoction to wash affected part, and embodiment 8 ointment
After 1 course for the treatment of of affected part is smeared in agent, the erythema overwhelming majority disappears, and symptom is wholly absent, and is continuing with 1 course for the treatment of, controls completely
More.Within 3 months, call-on back by phone does not recur.
Claims (10)
1. one kind for treating the pharmaceutical preparation of acute eczema, it is characterised in that described pharmaceutical preparation includes following Chinese crude drug: Folium Mori,
Cortex Phellodendri, Cortex Dictamni, XIAKUQIU, Radix Glycyrrhizae, Herba Taraxaci, the Rhizoma Atractylodis Macrocephalae, cooked Radix Notoginseng, Lignum Dalbergiae Odoriferae, Herba Capsellae, tasteless preserved soybean, Herba Moslae, Folium Nelumbinis,
Lagotis clarkei Hook. F (Lagotis brevituba Maxim.).
Pharmaceutical preparation the most according to claim 1, it is characterised in that described pharmaceutical preparation includes following weight portion Chinese crude drug:
Folium Mori 20-30 part, Cortex Phellodendri 8-15 part, Cortex Dictamni 10-30 part, XIAKUQIU 8-16 part, Radix Glycyrrhizae 4-12 part, Herba Taraxaci 10-15
Part, Rhizoma Atractylodis Macrocephalae 20-30 part, cooked Radix Notoginseng 10-19 part, Lignum Dalbergiae Odoriferae 5-11 part, Herba Capsellae 11-17 part, tasteless preserved soybean 5-11 part, Herba Moslae
7-12 part, Folium Nelumbinis 4-10 part, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.) 7-12 part.
Pharmaceutical preparation the most according to claim 1, it is characterised in that described pharmaceutical preparation includes following weight portion Chinese crude drug:
25 parts of Folium Mori, Cortex Phellodendri 12 parts, Cortex Dictamni 20 parts, XIAKUQIU 12 parts, 8 parts of Radix Glycyrrhizae, Herba Taraxaci 12.5 parts, the Rhizoma Atractylodis Macrocephalae 25
Part, cooked Radix Notoginseng 14.5 parts, Lignum Dalbergiae Odoriferae 8 parts, 14 parts of Herba Capsellae, tasteless preserved soybean 8 parts, Herba Moslae 10.5 parts, 7 parts of Folium Nelumbinis, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.)
9.5 part.
Pharmaceutical preparation the most according to claim 1, it is characterised in that described pharmaceutical preparation includes following weight portion Chinese crude drug:
26 parts of Folium Mori, Cortex Phellodendri 13 parts, Cortex Dictamni 19 parts, XIAKUQIU 13 parts, 9 parts of Radix Glycyrrhizae, Herba Taraxaci 13.5 parts, the Rhizoma Atractylodis Macrocephalae 24
Part, cooked Radix Notoginseng 14.5 parts, Lignum Dalbergiae Odoriferae 9 parts, 14 parts of Herba Capsellae, tasteless preserved soybean 9 parts, Herba Moslae 11.5 parts, 8 parts of Folium Nelumbinis, Lagotis clarkei Hook. F (Lagotis brevituba Maxim.)
10.5 parts.
Pharmaceutical preparation the most according to claim 1, it is characterised in that: described pharmaceutical composition is external preparation, preferably water
Decoct, ointment.
6. the pharmaceutical preparation prepared described in claim 1, it is characterised in that the concrete preparation process of described water decoction is:
1) each crude drug is filtered out according to each proportioning raw materials, standby after remove impurity；
2) crude drug of formula ratio is put in appropriate pure water, after fast fire is fried open, then decoct slowly 20 minutes, pour out decocting
Liquid.
7. the pharmaceutical preparation prepared described in claim 1, it is characterised in that the concrete preparation process of described ointment is:
1) Radix Glycyrrhizae, cooked Radix Notoginseng and Cortex Phellodendri are broken into fine powder and cross 80-100 mesh sieve；
2) by Ai Sangye, Cortex Dictamni, XIAKUQIU, Herba Taraxaci, the Rhizoma Atractylodis Macrocephalae, Lignum Dalbergiae Odoriferae, Herba Capsellae, tasteless preserved soybean, Herba Moslae, Folium Nelumbinis and Lagotis clarkei Hook. F (Lagotis brevituba Maxim.)
Roguing is cleaned, and intense fire is boiled, slow fire boiling 1.5h, decocts twice, merges decoction liquor, filters, and heating concentrates, and obtains concentration
Liquid；
3) by 1) fine powder and the step 2 of step) concentrated solution mix homogeneously, obtain mixture；
4) to 3) mixture of step adds pharmaceutically acceptable adjuvant, make ointment.
Ointment the most according to claim 7, it is characterised in that: step 4) described in mixture auxiliary with pharmaceutically acceptable
Material weight consumption ratio is 1: 4-8, more preferably 1:4.7-6.5.
Pharmaceutical preparation the most according to claim 1, it is characterised in that: described pharmaceutical preparation is in preparation treatment acute eczema medicine
Purposes.
Pharmaceutical preparation the most according to claim 1, it is characterised in that: described pharmaceutical preparation is in preparation treatment children's acute eczema
Purposes in medicine.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610257383.XA CN105770152A (en) | 2016-04-24 | 2016-04-24 | Pharmaceutic preparation for treating acute eczema and application thereof |
| CN201611057743.8A CN106421087A (en) | 2016-04-24 | 2016-11-27 | Pharmaceutical preparation for treating acute eczema, and use of pharmaceutical preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610257383.XA CN105770152A (en) | 2016-04-24 | 2016-04-24 | Pharmaceutic preparation for treating acute eczema and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105770152A true CN105770152A (en) | 2016-07-20 |
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ID=56398392
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610257383.XA Pending CN105770152A (en) | 2016-04-24 | 2016-04-24 | Pharmaceutic preparation for treating acute eczema and application thereof |
| CN201611057743.8A Withdrawn CN106421087A (en) | 2016-04-24 | 2016-11-27 | Pharmaceutical preparation for treating acute eczema, and use of pharmaceutical preparation |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611057743.8A Withdrawn CN106421087A (en) | 2016-04-24 | 2016-11-27 | Pharmaceutical preparation for treating acute eczema, and use of pharmaceutical preparation |
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| CN106963912B (en) * | 2017-03-31 | 2020-04-14 | 海南黎药堂生物科技开发有限公司 | Dalbergia wood compound composition for treating eczema and preparation method thereof |
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| CN104523944A (en) * | 2015-01-06 | 2015-04-22 | 中国人民解放军第二军医大学 | Traditional Chinese medicine for treating eczema and application thereof |
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2016
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Application publication date: 20160720 |