CN104815246A - Medicine used for nursing and treating burn due to invasion of interior by toxic fire and preparation method of medicine - Google Patents

Abstract

The invention discloses a medicine used for nursing and treating a burn due to invasion of interior by toxic fire and a preparation method of the medicine. Various raw materials of the medicine comprise houttuynia cordata, tartary buckwheat, chinaroot greenbrier, basil, rhizoma bolbostemmae, calamint, shrub althea flower, japanese violet herb or root, willow branch, centella, air-plant herb, veined liparis, hypericum ascyron, folium agaves america nae, tree beautyberry root and leaf, cacumen biotae, lalang grass rhizome, involucrate balanophora, cactus, chinese elm bark, capitate knotweed herb, cynanchum thesioides, menispennaceae, madder, siberian walking fern, umbrellaleaf, peach laurel root, pseudostellaria maximowicziana, dwarf lilyturf root, changium smyrnioides, bighead atractylodes rhizome, ficus formosana root and liquorice. The medicine used for nursing and treating the burn due to invasion of interior by toxic fire has the beneficial effects that detoxication, inflammation diminishing, cool blooding and hemostasis are taken as main treatment principles, blood activation for stopping pain is realized, and the burn due to invasion of interior by toxic fire is nursed and treated; and the medicine used for nursing and treating the burn due to invasion of interior by toxic fire realizes treatment based on syndrome differentiation, has strong targeting and obvious curative effect, can resist to infection, prevent the surface of a wound from diffusing and improve cytothesis and skin healing capability, is low in cost and simple in production process and can be easily accepted by a patient.

Description

A kind of medicine for swaged burn in nursing for treating fire-toxin and preparation method

Technical field

The present invention relates to pharmaceutical technology, particularly a kind of medicine for swaged burn in nursing for treating fire-toxin and preparation method.

Background technology

Burn refers to the damage caused by flame, high-temp solid and intense radiation heat.Burn is the tissue injury caused by high temperature, chemical substance or electricity.The degree of burn is by the height of temperature, the length of action time and different.The change of local can be divided into four degree.Lactic acid production during burn in visible blood increases, and the pH value of arteriovenous blood reduces, and along with organizing, blood capillary is handicapped to be increased the weight of, and anoxemia also increases weight.If burn surface area may be in peril of one's life when reaching more than 1/3rd of total body surface area.

The cause of disease:

Burn majority is because directly contacting high temp objects or being subject to caused by strong heat radiation, as heating power, chemical substance, electric energy, lonizing radiation etc.

Clinical manifestation:

The degree of burn is by the height of temperature, the length of action time and different.The order of severity of burn depends on scope and the degree of depth of wounded tissue, and depth of burn can be divided into I degree, II degree and III degree.Be specially:

I degree of burn injury is the lightest.Burned skin is rubescent, pain, obviously touch a tender spot, have and ooze out or edema.During light pressure injury, local bleaches, but does not have vesicle.

II degree of burn injury is darker.Skin blister.Take on a red color bottom vesicle or white, be filled with limpid, sticky liquid.Touch a tender spot responsive, bleach during compressing.

III degree of burn injury is the darkest.Burn surfaces can turn white, deliquescing or in black, carbonization hide-like.Owing to being become pale by burning skin, in pale skin people, be often mistaken as normal skin, but no longer variable color during compressing.The erythrocyte destroyed can make burn local skin be cerise, has vesicle once in a while, and the hair in burn district is easy to extract, and feels to go down.III degree of burn area does not generally have the pain sensation.Because the teleneuron of skin is destroyed.Burnt degree usually through in a few days, will could be distinguished dark II degree and burn with III degree.

At present, western medical treatment burn need apply a large amount of antibiotic to prevent traumatic infection, diffusion, therefore easily produces drug resistance, and toxic and side effects is larger; But when the quality of human immunoglobulin and lazy weight, cellular immune function are low, effects of antibiotics is also not satisfactory.Therefore, clinical market needs a kind ofly to treat burn new drug evident in efficacy, not only can infection, promotes that skin recovers, wound healing, and has no side effect.

Modern Chinese medicine thinks that burn is that pyretic toxicity people invade because heat-flash acts on human body, stagnation of QI-blood, and the lighter's skin and flesh rots, and severe one excessive noxious heat, injures cloudy liquid in body, or pyretic toxicity inside fire attack internal organs, so that internal organs are become estranged, imbalance of YIN and YANG.Therefore burn is divided into following several types by the traditional Chinese medical science:

1, burning hot impairment of body fluid: heating, xerostomia wish drink, constipation, oliguria with reddish urine; Red tongue, yellow fur, rapid pulse.

2, cloudy impairment of YANG takes off: pale complexion, spiritlessness and weakness, and breath is low short, spontaneous perspiration and cold extremities, and body temperature is anti-low, drowsiness, very then staring spells; Deep red tongue or purple dark, no fur, thready pulse being about to disappear.

3, fire-toxin caves in: high fever excessive thirst or unconsciousness due to high fever, restlessness, xerocheilia, constipation, oliguria with reddish urine; Deep red tongue, thready and rapid pulse.

4, QI and blood deficiency: low grade fever or do not generate heat, spiritlessness and weakness, inappetence, emaciated physique, lustreless complexion, wound granulation color is light, is difficult to healing; Light red tongue, white and thin fur, thready and weak pulse.

5, weakness of the spleen and stomach: with the passing of time, wound surface is difficult to healing to the course of disease, fatigue and weak, inappetence, waist distention and fullness in the abdomen, or vomiting and diarrhoea, lustreless complexion, emaciated physique; Light red tongue, tongue is greasy in vain, weak pulse.

Chinese traditional treatment burn, based on organic conception, carries out interim determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs for burn in various degree, treating both the principal and secondary aspects of a disease, targeting is comparatively strong, evident in efficacy, can infection, prevent wound surface from spreading, improve cytothesis, skin healing ability, animal economy immunity can be improved, promote Water-Electrolyte dynamic equilibrium, and not easily produce drug resistance, have no side effect, cost price is cheap, and patient is easy to accept.

Summary of the invention

Technical problem to be solved by this invention is, provides one and has with detoxicating, relieving inflammation, cooling blood for hemostasis for primary treatment principle, holds concurrently with the medicine of promoting blood circulation and stopping pain effect, swaged burn in nursing for treating fire-toxin.The present invention is based on organic conception, interim determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is carried out for burn in various degree, treating both the principal and secondary aspects of a disease, targeting is comparatively strong, evident in efficacy, can infection, prevent wound surface from spreading, improve cytothesis, skin healing ability, animal economy immunity can be improved, promote Water-Electrolyte dynamic equilibrium.

In order to realize foregoing invention object, the invention provides a kind of medicine for swaged burn in nursing for treating fire-toxin, described medicine comprises following raw medicinal material: Herba Houttuyniae, Radix Et Rhizoma Fagopyri Tatarici, Rhizoma Smilacis Chinensis, Herba Ocimi (Herba Ocimi Pilosi), Rhizoma Bolbostematis, Herba Clinopodii Polycephali, Flos Hibisci, Herba pimpinellae diversifoliae, Ramulus Salicis Babylonicae, Herba Centellae, Herba Bryophylli Pinnati, Herba Liparidis nervosae, Herba Hyperici, Folium Agaves variegatae, Radix seu Folium callicarpae arboreae, Cacumen Platycladi, Rhizoma Imperatae, Herba balanophorae involucratae, Radix et Caulis Opuntiae Dillenii, Cortex Ulmi Parvifoliae, Herba Polygoni Capitati, Herba Cynanchi Thesioidis, Radix Stephaniae Tetrandrae, Radix Rubiae, Herba Camptosori Sibirici, unmrellaleaf, Folium Aucubae chinensis root, rod rod grass, Radix Ophiopogonis, Radix Changii, the Rhizoma Atractylodis Macrocephalae, Radix Fici beecheyanae and Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 10-16 part, Radix Et Rhizoma Fagopyri Tatarici 5-10 part, Rhizoma Smilacis Chinensis 16-22 part, Herba Ocimi (Herba Ocimi Pilosi) 11-16 part, Rhizoma Bolbostematis 10-16 part, Herba Clinopodii Polycephali 12-17 part, Flos Hibisci 18-25 part, Herba pimpinellae diversifoliae 8-15 part, Ramulus Salicis Babylonicae 12-18 part, Herba Centellae 13-19 part, Herba Bryophylli Pinnati 15-24 part, Herba Liparidis nervosae 10-16 part, Herba Hyperici 17-26 part, Folium Agaves variegatae 15-25 part, Radix seu Folium callicarpae arboreae 10-18 part, Cacumen Platycladi 15-21 part, Rhizoma Imperatae 10-16 part, Herba balanophorae involucratae 8-17 part, Radix et Caulis Opuntiae Dillenii 13-20 part, Cortex Ulmi Parvifoliae 15-26 part, Herba Polygoni Capitati 11-18 part, Herba Cynanchi Thesioidis 10-19 part, Radix Stephaniae Tetrandrae 8-15 part, Radix Rubiae 10-18 part, Herba Camptosori Sibirici 13-19 part, unmrellaleaf 6-10 part, Folium Aucubae chinensis root 11-17 part, excellent careless 13-20 part, Radix Ophiopogonis 15-19 part, Radix Changii 16-21 part, Rhizoma Atractylodis Macrocephalae 13-19 part, Radix Fici beecheyanae 15-20 part and Radix Glycyrrhizae 16-23 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 11-15 part, Radix Et Rhizoma Fagopyri Tatarici 6-9 part, Rhizoma Smilacis Chinensis 17-21 part, Herba Ocimi (Herba Ocimi Pilosi) 12-15 part, Rhizoma Bolbostematis 11-14 part, Herba Clinopodii Polycephali 13-16 part, Flos Hibisci 19-23 part, Herba pimpinellae diversifoliae 9-13 part, Ramulus Salicis Babylonicae 13-17 part, Herba Centellae 14-18 part, Herba Bryophylli Pinnati 16-23 part, Herba Liparidis nervosae 11-15 part, Herba Hyperici 18-25 part, Folium Agaves variegatae 16-23 part, Radix seu Folium callicarpae arboreae 11-17 part, Cacumen Platycladi 16-20 part, Rhizoma Imperatae 11-15 part, Herba balanophorae involucratae 9-15 part, Radix et Caulis Opuntiae Dillenii 15-19 part, Cortex Ulmi Parvifoliae 16-23 part, Herba Polygoni Capitati 12-16 part, Herba Cynanchi Thesioidis 11-17 part, Radix Stephaniae Tetrandrae 9-13 part, Radix Rubiae 11-17 part, Herba Camptosori Sibirici 15-18 part, unmrellaleaf 6-9 part, Folium Aucubae chinensis root 12-16 part, excellent careless 14-19 part, Radix Ophiopogonis 16-18 part, Radix Changii 17-20 part, Rhizoma Atractylodis Macrocephalae 14-18 part, Radix Fici beecheyanae 16-19 part and Radix Glycyrrhizae 17-21 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 11 parts, Radix Et Rhizoma Fagopyri Tatarici 9 parts, Rhizoma Smilacis Chinensis 19 parts, Herba Ocimi (Herba Ocimi Pilosi) 12 parts, Rhizoma Bolbostematis 14 parts, Herba Clinopodii Polycephali 16 parts, Flos Hibisci 21 parts, Herba pimpinellae diversifoliae 9 parts, Ramulus Salicis Babylonicae 17 parts, Herba Centellae 15 parts, Herba Bryophylli Pinnati 16 parts, Herba Liparidis nervosae 15 parts, Herba Hyperici 25 parts, Folium Agaves variegatae 18 parts, Radix seu Folium callicarpae arboreae 11 parts, Cacumen Platycladi 20 parts, Rhizoma Imperatae 11 parts, Herba balanophorae involucratae 13 parts, Radix et Caulis Opuntiae Dillenii 15 parts, Cortex Ulmi Parvifoliae 23 parts, Herba Polygoni Capitati 13 parts, Herba Cynanchi Thesioidis 11 parts, Radix Stephaniae Tetrandrae 13 parts, 14 parts, Radix Rubiae, Herba Camptosori Sibirici 15 parts, unmrellaleaf 6 parts, Folium Aucubae chinensis root 16 parts, rod rod grass 16 parts, Radix Ophiopogonis 17 parts, Radix Changii 20 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Fici beecheyanae 19 parts and 17 parts, Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 12 parts, Radix Et Rhizoma Fagopyri Tatarici 8 parts, Rhizoma Smilacis Chinensis 17 parts, Herba Ocimi (Herba Ocimi Pilosi) 15 parts, Rhizoma Bolbostematis 11 parts, Herba Clinopodii Polycephali 15 parts, Flos Hibisci 23 parts, Herba pimpinellae diversifoliae 12 parts, Ramulus Salicis Babylonicae 15 parts, Herba Centellae 18 parts, Herba Bryophylli Pinnati 16 parts, Herba Liparidis nervosae 13 parts, Herba Hyperici 18 parts, Folium Agaves variegatae 16 parts, Radix seu Folium callicarpae arboreae 17 parts, Cacumen Platycladi 19 parts, Rhizoma Imperatae 13 parts, Herba balanophorae involucratae 15 parts, Radix et Caulis Opuntiae Dillenii 17 parts, Cortex Ulmi Parvifoliae 18 parts, Herba Polygoni Capitati 12 parts, Herba Cynanchi Thesioidis 15 parts, Radix Stephaniae Tetrandrae 11 parts, 11 parts, Radix Rubiae, Herba Camptosori Sibirici 18 parts, unmrellaleaf 7 parts, Folium Aucubae chinensis root 13 parts, rod rod grass 14 parts, Radix Ophiopogonis 16 parts, Radix Changii 17 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Radix Fici beecheyanae 18 parts and 19 parts, Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 15 parts, Radix Et Rhizoma Fagopyri Tatarici 6 parts, Rhizoma Smilacis Chinensis 21 parts, Herba Ocimi (Herba Ocimi Pilosi) 13 parts, Rhizoma Bolbostematis 13 parts, Herba Clinopodii Polycephali 13 parts, Flos Hibisci 19 parts, Herba pimpinellae diversifoliae 13 parts, Ramulus Salicis Babylonicae 13 parts, Herba Centellae 14 parts, Herba Bryophylli Pinnati 21 parts, Herba Liparidis nervosae 11 parts, Herba Hyperici 23 parts, Folium Agaves variegatae 23 parts, Radix seu Folium callicarpae arboreae 15 parts, Cacumen Platycladi 20 parts, Rhizoma Imperatae 11 parts, Herba balanophorae involucratae 9 parts, Radix et Caulis Opuntiae Dillenii 19 parts, Cortex Ulmi Parvifoliae 16 parts, Herba Polygoni Capitati 16 parts, Herba Cynanchi Thesioidis 17 parts, Radix Stephaniae Tetrandrae 9 parts, 17 parts, Radix Rubiae, Herba Camptosori Sibirici 16 parts, unmrellaleaf 9 parts, Folium Aucubae chinensis root 12 parts, rod rod grass 19 parts, Radix Ophiopogonis 18 parts, Radix Changii 19 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Radix Fici beecheyanae 16 parts and 21 parts, Radix Glycyrrhizae.

When the dosage form of described medicine is ointment, its preparation method comprises the following steps:

Described raw medicinal material is soaked 1-2 hour in described ratio mixing, is then placed in multi-function extractor, first time decocts 5-10 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, cooling, tinning after ultraviolet radiation sterilizing.

When the dosage form of described medicine is liniment, its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds coarse powder 8-10 times amount soak by water 1-3 hour, and second time adds coarse powder 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in the glycerol accounting for a and b mixture gross mass 10% after being mixed with fine powder b by fine powder a and make liniment.

When the dosage form of described medicine is spray, its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, 80-160 order filters, get 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

When the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

For solving the problems of the technologies described above, the present invention also provides a kind of medicine for the treatment of the burn of swaged in fire-toxin, and pharmaceutical dosage form is: decoction, tablet, film coated tablet, enteric coated tablet, sugar coated tablet, capsule, soft capsule, oral liquid, hard capsule, suck agent, electuary, honey refining pill, granule, powder, sublimed preparation, syrup; External drug dosage forms is liniment, drop, ointment, fumigant, patch, suppository, tincture, plaster, gel and spray.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention, holds concurrently for primary treatment principle with promoting blood circulation and stopping pain with detoxicating, relieving inflammation, cooling blood for hemostasis, swaged burn in nursing for treating fire-toxin; Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of the present invention, treating both the principal and secondary aspects of a disease, targeting is stronger, evident in efficacy, can infection, prevent wound surface from spreading, improve cytothesis, skin healing ability, improve animal economy immunity, promote Water-Electrolyte dynamic equilibrium, and not easily produce drug resistance, cost price is cheap, processing technology is simple, convenient drug administration, and patient is easy to accept.

Detailed description of the invention

The present invention is with detoxicating, relieving inflammation, cooling blood for hemostasis is primary treatment principle, hold concurrently with promoting blood circulation and stopping pain, swaged burn in nursing for treating fire-toxin, therefore select following raw medicinal material: Herba Houttuyniae, Radix Et Rhizoma Fagopyri Tatarici, Rhizoma Smilacis Chinensis, Herba Ocimi (Herba Ocimi Pilosi), Rhizoma Bolbostematis, Herba Clinopodii Polycephali, Flos Hibisci, Herba pimpinellae diversifoliae, Ramulus Salicis Babylonicae, Herba Centellae, Herba Bryophylli Pinnati, Herba Liparidis nervosae, Herba Hyperici, Folium Agaves variegatae, Radix seu Folium callicarpae arboreae, Cacumen Platycladi, Rhizoma Imperatae, Herba balanophorae involucratae, Radix et Caulis Opuntiae Dillenii, Cortex Ulmi Parvifoliae, Herba Polygoni Capitati, Herba Cynanchi Thesioidis, Radix Stephaniae Tetrandrae, Radix Rubiae, Herba Camptosori Sibirici, unmrellaleaf, Folium Aucubae chinensis root, rod rod grass, Radix Ophiopogonis, Radix Changii, the Rhizoma Atractylodis Macrocephalae, Radix Fici beecheyanae and Radix Glycyrrhizae.In its side, Herba Houttuyniae, Radix Et Rhizoma Fagopyri Tatarici, Rhizoma Smilacis Chinensis, Herba Ocimi (Herba Ocimi Pilosi), Rhizoma Bolbostematis, Herba Clinopodii Polycephali, Flos Hibisci, Herba pimpinellae diversifoliae, Ramulus Salicis Babylonicae, Herba Centellae detoxicating, relieving inflammation; Herba Bryophylli Pinnati, Herba Liparidis nervosae, Herba Hyperici, Folium Agaves variegatae, Radix seu Folium callicarpae arboreae, Cacumen Platycladi, Rhizoma Imperatae, Herba balanophorae involucratae, Radix et Caulis Opuntiae Dillenii, Cortex Ulmi Parvifoliae cooling blood for hemostasis; Herba Polygoni Capitati, Herba Cynanchi Thesioidis, Radix Stephaniae Tetrandrae anti-inflammatory analgetic; Radix Rubiae, Herba Camptosori Sibirici, unmrellaleaf, Folium Aucubae chinensis root blood circulation promoting and blood stasis dispelling; Rod rod grass, Radix Ophiopogonis, Radix Changii YIN nourishing and the production of body fluid promoting; The Rhizoma Atractylodis Macrocephalae, Radix Fici beecheyanae invigorating the spleen and benefiting QI; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Make a general survey of full side, compatibility scientific and precise.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Herba Houttuyniae: pungent, is slightly cold.Return lung meridian.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.For lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.

Radix Et Rhizoma Fagopyri Tatarici: be the root and rhizome of polygonaceae plant Radix Et Rhizoma Fagopyri Tatarici.Sweet; Property is put down.Return spleen; Stomach; Large intestine channel.Spleen invigorating row is stagnant; Regulating QI to relieve pain; Removing toxic substances and promoting subsidence of swelling.Main epigastric distending pain; Dyspepsia; Dysentery; Lumbago and skelalgia; Traumatic injury; Carbuncle malignant boil; Lyssodexis.

Rhizoma Smilacis Chinensis: be the rhizome of liliaceous plant Rhizoma Smilacis Chinensis.Sweet; Acid; Property is put down.Return liver; Kidney channel.Expelling wind and removing dampness; Removing toxicity for eliminating carbuncles.Main air pain of dampness syndrome; Stranguria with turbid discharge; Leukorrhagia; Have loose bowels; Dysentery; Carbuncle sore tumefacting virus; Stubborn dermatitis; Burn and scald.

Herba Ocimi (Herba Ocimi Pilosi): be the herb of labiate Herba Ocimi (Herba Ocimi Pilosi).Acrid in the mouth; Sweet; Warm in nature.Return lung; Spleen; Stomach; Large intestine channel.Dispelling wind to relieve the exterior syndrome; Removing dampness for regulating stomach; Promoting flow of QI and blood; Removing toxic substances and promoting subsidence of swelling.Main headache due to common cold; Fever and cough; Heatstroke; Accumulation of food in the stomach and intes tine due to indigestion; Anorexia; Distension and fullness in the abdomen pain; Vomiting and diarrhoea dysentery; Rheumatic arthralgia; Seminal emission; Menoxenia; Toothache halitosis; Bulbar conjunctiva polyp hides eyeball; Skin eczema; Urticaria pruritus; Traumatic injury; Snake bite and insect sting.

Rhizoma Bolbostematis: be the bulb of cucurbitaceous plant Bolbostemma paniculatum.Bitter in the mouth; Cool in nature.Return lung; Spleen channel.Removing heat-phlegm; Eliminating stagnation is drawn out pus by applying a plaster to the affected part.Main acute mastitis; Scrofula sucutaneous nodule; Sore swollen toxin; Snakeworm crows wound.

Herba Clinopodii Polycephali: be the herb of labiate Herba Clinopodii Polycephali.Acrid in the mouth; Bitter; Cool in nature.Wind and heat dispersing; Removing toxic substances and promoting subsidence of swelling; Hemostasis.Main cold, fever; Heatstroke; Laryngopharynx swelling and pain; Diphtheria; Acute cholecystitis; Hepatitis; Intestinal is scorching; Dysentery is scorching; Dysentery; Rib adenitis; Mastitis; Furuncle swelling toxin; Allergic dermatitis; Acute conjunctivitis; Hematuria; Metrorrhagia; Gingival hemorrhage; Traumatic hemorrhage.

Flos Hibisci: be the flower of Malvaceae plant Hibiscus syriacus L..Sweet; Bitter; Cool.Return spleen; Lung; Liver Channel.Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.Main hemorrhoidal hamorrhage rushes down blood; Red white dysentery; Bleeding hemorrhoids; Cough due to lung-heat; Hemoptysis; Leucorrhea; Furuncle carbuncle; Scald.

Herba pimpinellae diversifoliae: be the herb of the different leaf Pimpinella anisum Linn. of samphire.Acrid in the mouth; Bitter; Micro-sweet; Slightly warm in nature.Return lung; Stomach; Liver Channel.Loose wind lung qi dispersing; Regulating QI to relieve pain; Removing food stagnancy spleen invigorating; Promoting blood circulation to restore menstrual flow; Removing dampness and detoxicating.Main flu; Cough; Pertussis; Pulmonary tuberculosis; Lung abscess; Headache; Headache; Bud pain; Crisp hypochondriac pain; Peratodynia; Abdominal distention and pain; Koro cold type of pain; Rheumatic arthritis; Impairment caused by overstrain; Bone labor; Dyspepsia; Food stagnation; Infantile malnutrition; Acute filthy disease; Dysentery; Jaundice; Malaria; Menoxenia; Dysmenorrhea; Amenorrhea; Swelling of the breast; Corneal nebula; Pharyngeal swelling; Mumps; Traumatic injury; Eczema; Skin pruritus; Snakeworm hinders.

Ramulus Salicis Babylonicae: be the branch of Salicaceous Plants Salix babylonica L..Bitter; Cold in nature.Return stomach; Liver Channel.Expelling wind and removing dampness; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Stranguria with turbid discharge; Jaundice; Rubella pruritus; Furuncle; Erysipelas, dental caries; Swelling of the gum.

Herba Centellae: be the herb of samphire Herba Centellae.Bitter in the mouth; Pungent; Cold in nature.Return lung; Spleen kidney; Urinary bladder channel.Clearing away heat-damp and promoting diuresis; Promoting blood circulation and hemostasis; Removing toxic substances and promoting subsidence of swelling.Main heating; Cough with asthma; Laryngopharynx swelling and pain; Intestinal is scorching; Dysentery; Jaundice due to damp-heat; Edema; Stranguria; Hematuria; Epistaxis; Dysmenorrhea; Metrorrhagia; Erysipelas; Scrofula; Parent's pyogenic infections from tumour or sore; Herpes zoster; Treating swelling and pain by traumatic injury; Traumatic hemorrhage; Snake bite and insect sting.

Herba Bryophylli Pinnati: be root and the herb of crassulaceae plants Herba Bryophylli Pinnati.Bitter; Acid; Cold.Return lung; Kidney channel.Cooling blood for hemostasis; Heat-clearing and toxic substances removing.Main lobe blood; Traumatic hemorrhage; Traumatic injury; Furuncle carbuncle; Acute mastitis; Acute mastitis; Breast carcinoma; Erysipelas; Ulcer; Scald; Stomachache; Arthralgia; Laryngopharynx swelling and pain; Cough due to lung-heat.

For the herb of orchid arteries and veins fen orchid.

Herba Liparidis nervosae: another name is shown in that scarlet bloodlily, short and stout youngster, meat Eriocheir sinensis, ferrum are climbed tree.For the orchid family Liparis plant fen orchid, with all herbal medicine.Bitter; Puckery; Cool.Return lung; Kidney channel.Cooling blood for hemostasis; Heat-clearing and toxic substances removing.Main gastric heat is spitted blood; Lung-heat is spat blood; Discharging fresh blood stool; Metrorrhagia; Operative hemorrhage; Wound hemorrhage; Sore swollen toxin; Venom; Traumatic injury.

Herba Hyperici: be the herb of Garcinia maingayii hypericum ascyron.Bitter; Cold.Return Liver Channel.Cooling blood for hemostasis; Promoting blood flow to regulate menstruation; Heat-clearing and toxic substances removing.Main heat in blood is caused spits blood; Spitting of blood; Hematuria; Have blood in stool; Metrorrhagia; Traumatic injury; Traumatic hemorrhage; Menoxenia; Dysmenorrhea; Agalactia; Anemopyretic cold; Malaria; Hepatitis; Dysentery; Diarrhoea; Venom; Scald; Eczema; Impetigo.

Folium Agaves variegatae: be the leaf of Agavaceae plant Folium Agaves variegatae.Sweet; Micro-pungent; Cool.Nourishing the lung to arrest cough; Cooling blood for hemostasis; Heat-clearing and toxic substances removing.Main xeropulmonary cough; Spitting of blood; Dyspnea due to deficiency; Measles without adequate eruption; Carbuncle sore tumefacting virus; Burn and scald.

Radix seu Folium callicarpae arboreae: be root, the leaf of dicotyledon medicine Verbenaceae Nan Yang Folium Callicarpae Formosanae.Micro-bitterness; Flat.Return Liver Channel.Astringing to arrest bleeding; Heat-clearing and toxic substances removing.Main epistaxis; Spitting of blood; Gastrointestinal hemorrhage; Woman uterine bleeding; Laryngopharynx swelling and pain; Traumatic hemorrhage; Burn.

Cacumen Platycladi: be branch top and the leaf of Cupressaceae plant Cacumen Platycladi.Bitter; Puckery; Cold nature.Return lung; Liver; Large intestine channel.Cooling blood for hemostasis; Eliminating phlegm and stopping cough; Wind-damp dispelling; Loose toxic swelling.Cure mainly spitting of blood; Spit blood; Epistaxis; Hematuria; Dysentery; Discharging fresh blood stool; Metrorrhagia is more than; Cough with copious phlegm; Rheumatic arthralgia; Erysipelas; Mumps, scalds.

Rhizoma Imperatae: this product is the dry rhizome of grass Herba Imperatae.Sweet, cold.Return lung, stomach, urinary bladder channel.Cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.

Herba balanophorae involucratae: be the herb of Balanophoraceae plant Balanophora involicrata Hook.f..Bitter; Puckery; Cold in nature.Return lung; Stomach; Liver Channel.Nourishing the lung to arrest cough; Circulation of qi promoting stomach invigorating; Clearing away heat-damp and promoting diuresis; Cooling blood for hemostasis; The kidney invigorating arresting seminal emission.Main cough due to lung-heat; Epigastric pain, jaundice; Swelling and pain of hemorrhoid; Traumatic injury; Spitting of blood; Menoxenia; Metrorrhagia; Traumatic hemorrhage; Dizzy; Seminal emission.

Radix et Caulis Opuntiae Dillenii: be root and the stem of Cactaeous plants Radix et Caulis Opuntiae Dillenii and green Radix et Caulis Opuntiae Dillenii.Bitter; Cold in nature.GUIXIN; Lung; Stomach warp.Promoting flow of QI and blood; Heat-clearing and toxic substances removing; Cooling blood for hemostasis; Clearing away lung-heat to relieve cough.Main stomachache; Mass in the abdomen; Dysentery; Laryngalgia; Cough due to lung-heat; Pulmonary tuberculosis is spat blood; Spit blood; Hemorrhoidal bleeding; Skin infection furuncle furuncle; Acute mastitis; To itch the cheek; Tinea disease; Snake bite and insect sting; Scald; Cold injury.

Herba Polygoni Capitati: be the herb of polygonaceae plant Herba Polygoni Capitati.Bitter; Pungent; Cool in nature.Clearing away heat-damp and promoting diuresis; Promoting blood circulation and stopping pain.Main dysentery; Pyelonephritis; Cystitis; Lithangiuria; Rheumatalgia; Traumatic injury; Mumps; Skin infection; Eczema.

Herba Cynanchi Thesioidis: be the herb of dicotyledon medicine asclepiadaceae plant spire Rhizoma Cynanchi Stauntonii.Sweet in the mouth; Cool in nature.Return lung meridian.Tonifying the lung gas; Resolving heat and reducing pathogenic fire; Promoting the production of body fluid to quench thirst; Anti-inflammatory analgetic.Main hyperactivity of deficient fire; Have sore throat; Deficiency of both vital energy and Yin; Mental fatigue is forgetful; Fidgets due to deficiency is thirsty; Dizzy insomnia; Puerperal asthenia.

radix Stephaniae Tetrandrae: this product is the dry root of menispermaceous plants Radix stephaniae tetrandrae.Hardship, cold.Return bladder, lung meridian.Inducing diuresis to remove edema, wind-expelling pain-stopping.For edema beriberi, dysuria, eczema sore, rheumatic arthralgia; Hypertension.

Cortex Ulmi Parvifoliae: be bark, the root bark of Ulmaceae Cortex Ulmi Parvifoliae.Sweet; Micro-hardship; Cold in nature.Clearing away heat and promoting diuresis; Removing toxic substances and promoting subsidence of swelling; Cooling blood for hemostasis.Main pyretic stranguria; Dysuria; Sore swollen toxin; Acute mastitis; Burn due to hot liquid or fire; Dysentery; Gastrointestinal hemorrhage; Hematuria; Hemorrhoidal bleeding; Aching pain in waist and back; Traumatic hemorrhage.

Radix Rubiae: bitter; Tremble with fear and return liver; Heart channel.Return liver; The heart; Kidney; Spleen; Stomach; Pericardium channel.Cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling.Main heat in blood spitting of blood; Spit blood; Epistaxis; Hematuria; Have blood in stool; Metrorrhagia; Amenorrhea; Postpartum stagnation is suffered from abdominal pain; Traumatic injury; Rheumatic arthralgia; Jaundice; Carbuncle sore; Hemorrhoid swell.

Herba Camptosori Sibirici: be the herb of Aspleniaceae plant walking fern.Light; Flat.GUIXIN warp.Blood circulation promoting and blood stasis dispelling; Hemostasis; Removing toxic substances.Main thromboangiitis obliterans; Hemiplegia; Metrorrhagia; Traumatic hemorrhage; Neurodermatitis; Ulcer of the lower limb.

Unmrellaleaf: be Berberidaceae Diphylleia plant unmrellaleaf, be used as medicine with root stock.Bitter, pungent, temperature.Blood circulation promoting and blood stasis dispelling, removing toxic substances and promoting subsidence of swelling.For traumatic injury, bones and muscles pain due to rheumatism, menoxenia, lower abdomen pain; Venom is controlled in external, carbuncle furuncle and phyma poison.

Folium Aucubae chinensis root: be the root of Cornaceae plant moth eyebrows peach jaurel or peach jaurel.Bitter in the mouth; Pungent; Warm in nature.Expelling wind and removing dampness; Blood circulation promoting and blood stasis dispelling.Main air pain of dampness syndrome; Traumatic injury congestive edema.

Rod rod grass: another name Radix Ginseng.For the dried root of the short and small Radix Ginseng of pinkwort.Sweet; Bitter; Tepor.Tonifying the lung; Spleen invigorating; YIN nourishing and the production of body fluid promoting.Main cough due to deficiency of the lung; Insufficiency of the spleen lack of appetite; Cardiopalmus spontaneous perspiration; Tired out weak; Xerostomia.

Radix Ophiopogonis: be the tuber of liliaceous plant Radix Ophiopogonis or dwarf lilyturf.Sweet; Micro-hardship; Cold.Return lung; Stomach; Heart channel.Nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Clear away heart-fire relieving restlessness.Main dryness of the lung dry cough; Lung abscess; Deficiency of YIN chronic cough; Tianjin wound is thirsty; Quench one's thirst; Vexed insomnia; Have sore throat; Dryness of the intestine constipation; Heat in blood tells nosebleed.

Radix Changii: be the root of samphire Radix Changii.Sweet, micro-hardship, is slightly cold.Return lung, spleen, Liver Channel.Moistening the lung and resolving phlegm, yin nourishing stomach function regulating, suppressing the hyperactive liver, removing toxic substances.For cough due to lung-heat, vomiting regurgitation, lack of appetite xerostomia, conjunctival congestion is dizzy, furunculosis skin infection.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Return spleen; Stomach warp.Invigorating the spleen and benefiting QI; Dampness diuretic; Hidroschesis; Antiabortive.Main deficiency-weakness of spleen-QI; Spiritlessness and weakness; The few abdominal distention of lack of appetite; Large loose stool is thin; Fluid-retention stagnating in the interior; Dysuria; Edema; Dizziness due to fluid-retention; Temperature numbness is ached; Spontaneous sweating due to deficiency of QI; Frequent fetal movement.

Radix Fici beecheyanae: be the root of moraceae plants Fructus Fici Beecheyanae.Sweet; Pungent; Warm in nature.Return lung; Spleen; Kidney channel.Replenishing QI to invigorate the spleen; Promoting blood circulation to remove obstruction in the collateral; Expelling wind and removing dampness.Main overstrain is weak; Lack of appetite; Agalactia; Insufficiency of the spleen leucorrhea; Proctoptosis; Menoxenia; Wind syndrome of head pain; Traumatic injury; Rheumatic arthralgia.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 ointment of the present invention

Get Herba Houttuyniae 11g, Radix Et Rhizoma Fagopyri Tatarici 9g, Rhizoma Smilacis Chinensis 19g, Herba Ocimi (Herba Ocimi Pilosi) 12g, Rhizoma Bolbostematis 14g, Herba Clinopodii Polycephali 16g, Flos Hibisci 21g, Herba pimpinellae diversifoliae 9g, Ramulus Salicis Babylonicae 17g, Herba Centellae 15g, Herba Bryophylli Pinnati 16g, Herba Liparidis nervosae 15g, Herba Hyperici 25g, Folium Agaves variegatae 18g, Radix seu Folium callicarpae arboreae 11g, Cacumen Platycladi 20g, Rhizoma Imperatae 11g, Herba balanophorae involucratae 13g, Radix et Caulis Opuntiae Dillenii 15g, Cortex Ulmi Parvifoliae 23g, Herba Polygoni Capitati 13g, Herba Cynanchi Thesioidis 11g, Radix Stephaniae Tetrandrae 13g, Radix Rubiae 14g, Herba Camptosori Sibirici 15g, unmrellaleaf 6g, Folium Aucubae chinensis root 16g, excellent careless 16g, Radix Ophiopogonis 17g, Radix Changii 20g, Rhizoma Atractylodis Macrocephalae 14g, Radix Fici beecheyanae 19g and Radix Glycyrrhizae 17g.

Its preparation method comprises the following steps:

By described raw medicinal material in described ratio mixing immersion 2 hours, be then placed in multi-function extractor, first time decocts 8 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 9 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.08MPa, temperature remains on 70 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C, cooling, tinning after ultraviolet radiation sterilizing.

Embodiment 2 liniment of the present invention

Get Herba Houttuyniae 12g, Radix Et Rhizoma Fagopyri Tatarici 8g, Rhizoma Smilacis Chinensis 17g, Herba Ocimi (Herba Ocimi Pilosi) 15g, Rhizoma Bolbostematis 11g, Herba Clinopodii Polycephali 15g, Flos Hibisci 23g, Herba pimpinellae diversifoliae 12g, Ramulus Salicis Babylonicae 15g, Herba Centellae 18g, Herba Bryophylli Pinnati 16g, Herba Liparidis nervosae 13g, Herba Hyperici 18g, Folium Agaves variegatae 16g, Radix seu Folium callicarpae arboreae 17g, Cacumen Platycladi 19g, Rhizoma Imperatae 13g, Herba balanophorae involucratae 15g, Radix et Caulis Opuntiae Dillenii 17g, Cortex Ulmi Parvifoliae 18g, Herba Polygoni Capitati 12g, Herba Cynanchi Thesioidis 15g, Radix Stephaniae Tetrandrae 11g, Radix Rubiae 11g, Herba Camptosori Sibirici 18g, unmrellaleaf 7g, Folium Aucubae chinensis root 13g, excellent careless 14g, Radix Ophiopogonis 16g, Radix Changii 17g, Rhizoma Atractylodis Macrocephalae 18g, Radix Fici beecheyanae 18g and Radix Glycyrrhizae 19g.

Its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds coarse powder 8 times amount soak by water 2 hours, and second time adds coarse powder 6 times amount soak by water 1 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in the glycerol accounting for a and b mixture gross mass 10% after being mixed with fine powder b by fine powder a and make liniment.

Embodiment 3 spray of the present invention

Get Herba Houttuyniae 15g, Radix Et Rhizoma Fagopyri Tatarici 6g, Rhizoma Smilacis Chinensis 21g, Herba Ocimi (Herba Ocimi Pilosi) 13g, Rhizoma Bolbostematis 13g, Herba Clinopodii Polycephali 13g, Flos Hibisci 19g, Herba pimpinellae diversifoliae 13g, Ramulus Salicis Babylonicae 13g, Herba Centellae 14g, Herba Bryophylli Pinnati 21g, Herba Liparidis nervosae 11g, Herba Hyperici 23g, Folium Agaves variegatae 23g, Radix seu Folium callicarpae arboreae 15g, Cacumen Platycladi 20g, Rhizoma Imperatae 11g, Herba balanophorae involucratae 9g, Radix et Caulis Opuntiae Dillenii 19g, Cortex Ulmi Parvifoliae 16g, Herba Polygoni Capitati 16g, Herba Cynanchi Thesioidis 17g, Radix Stephaniae Tetrandrae 9g, Radix Rubiae 17g, Herba Camptosori Sibirici 16g, unmrellaleaf 9g, Folium Aucubae chinensis root 12g, excellent careless 19g, Radix Ophiopogonis 18g, Radix Changii 19g, Rhizoma Atractylodis Macrocephalae 16g, Radix Fici beecheyanae 16g and Radix Glycyrrhizae 21g.

Its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add the water soaking 6 hours relative to the mixture quality 4 times obtained, after intense fire boils, using slow fire instead, to decoct the 50 minutes dosage to medicinal liquid be slowly 300ml, decocts 3 times, merges decoction liquor and filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 90% soak with ethanol 1 hour, extract twice, each 2 hours, merge extractive liquid, 140 orders filter, get 8000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

Embodiment 4 granule of the present invention

Get Herba Houttuyniae 15g, Radix Et Rhizoma Fagopyri Tatarici 6g, Rhizoma Smilacis Chinensis 21g, Herba Ocimi (Herba Ocimi Pilosi) 13g, Rhizoma Bolbostematis 13g, Herba Clinopodii Polycephali 13g, Flos Hibisci 19g, Herba pimpinellae diversifoliae 13g, Ramulus Salicis Babylonicae 13g, Herba Centellae 14g, Herba Bryophylli Pinnati 21g, Herba Liparidis nervosae 11g, Herba Hyperici 23g, Folium Agaves variegatae 23g, Radix seu Folium callicarpae arboreae 15g, Cacumen Platycladi 20g, Rhizoma Imperatae 11g, Herba balanophorae involucratae 9g, Radix et Caulis Opuntiae Dillenii 19g, Cortex Ulmi Parvifoliae 16g, Herba Polygoni Capitati 16g, Herba Cynanchi Thesioidis 17g, Radix Stephaniae Tetrandrae 9g, Radix Rubiae 17g, Herba Camptosori Sibirici 16g, unmrellaleaf 9g, Folium Aucubae chinensis root 12g, excellent careless 19g, Radix Ophiopogonis 18g, Radix Changii 19g, Rhizoma Atractylodis Macrocephalae 16g, Radix Fici beecheyanae 16g and Radix Glycyrrhizae 21g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.10, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.4 times and 0.2 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.

Toxicity test:

Hypersensitive test:

Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration; The test group ointment of the embodiment of the present invention 1.The ointment 0.1g getting the embodiment of the present invention 1 is applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, the same area smeared this product 0.1g, at once observes after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Hypersensitive test:

Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration; The test group spray of the embodiment of the present invention 3.Get the spray of the embodiment of the present invention 3 in unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, spray this product 1 time at back the same area, at once observe after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Acute skin irritation test:

These product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, the liniment prepared by embodiments of the invention 2 to be directly coated on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.

Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 4 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the granule acute toxicity of the embodiment of the present invention 4 is low, clinical drug safety.

Clinical data:

Case selection: choose standard compliant patient 352 example, be II °-eschar burn, the vesicle do not waited sized by the performance of wound surface situation, takes on a red color bottom vesicle or white, is filled with limpid, sticky liquid; It is obvious that contaminated wound surface creates all congestion and swelling pains, has purulent secretion.Wherein, man 253 example, female 99 example; Age 3-71 year, 44 years old mean age; Flame burn (firewood, electric spark, fireworks and firecrackers etc.) 98 example, hot liquid scald (boiled water, hot medicated porridge, the oil that boils, containing alkalescence paper pulp etc.) 254 example; Based on extremity trunk, throughout head, face, extremity, trunk; Patient's restlessness, xerocheilia, constipation, oliguria with reddish urine; Deep red tongue, thready and rapid pulse, dialectically to belong in fire-toxin swaged burn.

352 routine patients are divided into four groups at random, four groups in age, sex and the course of disease without significant difference, there is comparability.

Ointment+Granules in Treating group: 88 people, male 64 people, female 24 people.

Liniment+Granules in Treating group: 88 people, male 63 people, female 25 people.

Spray+Granules in Treating group: 88 people, male 63 people, female 25 people.

MEIBAO SHIRUN SHAOSHANG GAO matched group: 88 people, male 63 people, female 25 people.

Diagnostic criteria:

Burn degree: the degree of depth adopting three degree of international quarterings to judge burn more:

I °: pathological changes is the lightest.Generally injure horny layer of epidermis, clear layer, granular layer, regeneration capacity is strong.Scorch degree of depth erythema shape, pain, hyperesthesia.The normal recovery from illness of (3-5 days) desquamation in a short time, does not leave over cicatrix.Sometimes pigmentation is had.

Light Ⅱ°: injure the stratum germinativum of epidermis, papillary layer of corium.The regeneration of epithelium depends on remaining stratum germinativum and the adnexa of skin.Local is obviously red and swollen, and vesicle is comparatively large, and after removing epidermal area, wound surface is moistening, wound end bright red, and has red granules or venation shape vasoganglion.As without infecting, generally healing after one or two week, also not staying cicatrix.Sometimes the pigment alteration of long period is had.

DepthⅡ°: the skin corium injuring below dermal papilla layer, but still remain some dermis.Long-pending thin liquid under epidermis, or vesicle is less, and after removing epidermis, wound surface is micro-wet or red and white, and visible many dots in red or minute blood vessel sometimes, edema is obvious.Insensitive.More leave over cicatrix after, the chance that scar tissue hypertrophy occurs is also more more.As nothing infects, healing time generally needs three surroundings.As infected, not only healing time extends, and the appendages of skin or epithelium island can be destroyed time serious, wound surface must can heal in skin-grafting.

III °: full thickness bums even reaches subcutaneous, muscle or skeleton.Wound surface analgesis, in eschar shape, the blood vessel of visible dendroid thromboembolism under crust.Pain disappears.Because skin and adnexa thereof are all ruined, wound surface is without the source of epithelium regeneration, and reparation must depend on skin-grafting and skin flap transplantation reparation, and severe patient needs row amputation.

Therapeutic Method:

First adopt cold water external application or use tap water wound surface, to reduce heating power to the damage of integumentary musculature as far as possible; Around simple removing wound surface and wound surface after foreign body, rinse with 0.9% sodium chloride solution, then with 1 ‰ bromogeramine solutions sterilizations, sterile gauze wipes dry wound surface water liquid, and the bleb skin of pollution is stripped off in cleaning, large vesicle gives tapping and subtracts and open.

Ointment+Granules in Treating group: directly smear affected part with the wound surface of ointment to women's head-ornaments, perineal position prepared by the embodiment of the present invention 1, every 4h once, and the secretions around cleaning in time, to the wound surface of trunk, extremity, all adopt multilamellar to scribble the gauze external application of ointment, aseptic dressing is wrapped up, every day changes dressings once, until wound healing, for the wound surface polluted, scribble ointment yarn external application wrapping with monolayer after debridement, change dressings every day 2 times; The granule of the oral embodiment of the present invention 4 simultaneously, every day 3 times, one time 1 bag; It within every 14 days, is 1 course for the treatment of.

Liniment+Granules in Treating group: smear affected part with liniment prepared by the embodiment of the present invention 2, directly be coated with affected part to the wound surface of women's head-ornaments, perineal position, every 4h once, and clears up secretions around in time, to the wound surface of trunk, extremity, all adopt multilamellar to scribble the gauze external application of liniment, aseptic dressing is wrapped up, and changes dressings every day 1 time, until wound healing, for the wound surface polluted, scribble liniment yarn external application wrapping with monolayer after debridement, change dressings every day 2 times; The granule of the oral embodiment of the present invention 4 simultaneously, every day 3 times, one time 1 bag; It within every 14 days, is 1 course for the treatment of.

Spray+Granules in Treating group: the spray spraying affected part of preparing by the embodiment of the present invention 3, to the wound surface direct spraying affected part of women's head-ornaments, perineal position, every 4h once, and clears up secretions around in time, to the wound surface of trunk, extremity, all adopt multilamellar to be sprayed with the gauze external application of spray, aseptic dressing is wrapped up, and changes dressings every day once, until wound healing, for the wound surface polluted, be sprayed with spray yarn external application wrapping with monolayer after debridement, change dressings every day 2 times; The granule of the oral embodiment of the present invention 4 simultaneously, every day 3 times, one time 1 bag; It within every 14 days, is 1 course for the treatment of.

MEIBAO SHIRUN SHAOSHANG GAO matched group: be coated with MEIBAO SHIRUN SHAOSHANG GAO to the wound surface of women's head-ornaments, perineal position is directly outer, every 4h once, and the secretions around cleaning in time, to the wound surface of trunk, extremity, all adopt multilamellar to scribble the gauze external application of MEIBAO SHIRUN SHAOSHANG GAO, aseptic dressing is wrapped up, every day changes dressings once, until wound healing, for the wound surface polluted, scribble MEIBAO SHIRUN SHAOSHANG GAO yarn external application wrapping with monolayer after debridement, change dressings every day 2 times; Take Amoxicillin Capsules simultaneously, one time 2,2 times on the one; It within 14 days, is a course for the treatment of.

Criterion of therapeutical effect:

Be diagnosis basis according to international and China's general it " three degree of quarterings ".

Cure: after the treatment, infect various deep burn and the patient of different area, in 1 course for the treatment of, skin ulcer face occurs that first phase physiological heals, and does not stay dysfunction, cicatrix, contracture, vitreous degeneration etc.;

Effective: after the treatment, in 10 ~ 60min, pain is alleviated, and swelling fades, or in 1 week, skin ulcer face occurs that physiological reverse is effective;

Invalid: after the treatment, do not occur in 1 course for the treatment of that physiological reverses as invalid.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt swaged burn in Drug therapy fire-toxin of the present invention, relative to matched group on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt swaged burn in Drug therapy fire-toxin of the present invention, relative to matched group, treatment time significantly shortens.

After table 1 Four composition does not treat two courses for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Cure	Effectively	Invalid	Total effective rate
						Ointment+Granules in Treating group	88	39	49	0	100%
Liniment+Granules in Treating group	88	37	51	0	100%
						Spray+Granules in Treating group	88	38	50	0	100%
MEIBAO SHIRUN SHAOSHANG GAO matched group	88	23	60	5	94.3%

The wound healing time that four groups, table 2 is cured and the average healing compare

Group	Number of cases	Wound healing time (my god)	The average healing (my god)
				Ointment+Granules in Treating group	39	15-22	18.5±1.3
Liniment+Granules in Treating group	37	16-24	18.7±1.6
				Spray+Granules in Treating group	38	15-22	17.8±1.4
MEIBAO SHIRUN SHAOSHANG GAO matched group	23	21-33	25.7±1.6

According to the clinical statistics in above table, medicine provided by the invention has determined curative effect in swaged burn in treatment fire-toxin, rapid-action, effective percentage is high, safety is high, the advantage that has no side effect.

Model case:

Single certain, female, 39 years old, plant operations workman.In November, 2012 is burnt because of workshop breaking out of fire, proceeds to my institute in other hospitalizes after 10 days.Patient's unconsciousness due to high fever, xerocheilia, constipation, oliguria with reddish urine, deep red tongue, thready and rapid pulse.Wound surface is infected, and wound week is red and swollen, and have purulent secretion to ooze out, unbearably, be II °-eschar burn after diagnosing, Chinese medical discrimination is swaged in fire-toxin to patient pain.The spray of the embodiment of the present invention 3 and the capsule of embodiment 4 is used to treat.After debridement, with the spray gauze external application wrapping being sprayed with the embodiment of the present invention 3, change dressings every day 2 times, simultaneously the granule of the oral embodiment of the present invention 4, every day 3 times, one time 1 bag.After 7d, patient mental's amelioration, after 15d, most of wound surface starts healing, and 21d patient's recovery from illness of being in hospital is left hospital.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. the medicine for swaged burn in nursing for treating fire-toxin, it is characterized in that, described medicine comprises following raw medicinal material: Herba Houttuyniae, Radix Et Rhizoma Fagopyri Tatarici, Rhizoma Smilacis Chinensis, Herba Ocimi (Herba Ocimi Pilosi), Rhizoma Bolbostematis, Herba Clinopodii Polycephali, Flos Hibisci, Herba pimpinellae diversifoliae, Ramulus Salicis Babylonicae, Herba Centellae, Herba Bryophylli Pinnati, Herba Liparidis nervosae, Herba Hyperici, Folium Agaves variegatae, Radix seu Folium callicarpae arboreae, Cacumen Platycladi, Rhizoma Imperatae, Herba balanophorae involucratae, Radix et Caulis Opuntiae Dillenii, Cortex Ulmi Parvifoliae, Herba Polygoni Capitati, Herba Cynanchi Thesioidis, Radix Stephaniae Tetrandrae, Radix Rubiae, Herba Camptosori Sibirici, unmrellaleaf, Folium Aucubae chinensis root, rod rod grass, Radix Ophiopogonis, Radix Changii, the Rhizoma Atractylodis Macrocephalae, Radix Fici beecheyanae and Radix Glycyrrhizae.

2. medicine according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 10-16 part, Radix Et Rhizoma Fagopyri Tatarici 5-10 part, Rhizoma Smilacis Chinensis 16-22 part, Herba Ocimi (Herba Ocimi Pilosi) 11-16 part, Rhizoma Bolbostematis 10-16 part, Herba Clinopodii Polycephali 12-17 part, Flos Hibisci 18-25 part, Herba pimpinellae diversifoliae 8-15 part, Ramulus Salicis Babylonicae 12-18 part, Herba Centellae 13-19 part, Herba Bryophylli Pinnati 15-24 part, Herba Liparidis nervosae 10-16 part, Herba Hyperici 17-26 part, Folium Agaves variegatae 15-25 part, Radix seu Folium callicarpae arboreae 10-18 part, Cacumen Platycladi 15-21 part, Rhizoma Imperatae 10-16 part, Herba balanophorae involucratae 8-17 part, Radix et Caulis Opuntiae Dillenii 13-20 part, Cortex Ulmi Parvifoliae 15-26 part, Herba Polygoni Capitati 11-18 part, Herba Cynanchi Thesioidis 10-19 part, Radix Stephaniae Tetrandrae 8-15 part, Radix Rubiae 10-18 part, Herba Camptosori Sibirici 13-19 part, unmrellaleaf 6-10 part, Folium Aucubae chinensis root 11-17 part, excellent careless 13-20 part, Radix Ophiopogonis 15-19 part, Radix Changii 16-21 part, Rhizoma Atractylodis Macrocephalae 13-19 part, Radix Fici beecheyanae 15-20 part and Radix Glycyrrhizae 16-23 part.

3. medicine according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 11-15 part, Radix Et Rhizoma Fagopyri Tatarici 6-9 part, Rhizoma Smilacis Chinensis 17-21 part, Herba Ocimi (Herba Ocimi Pilosi) 12-15 part, Rhizoma Bolbostematis 11-14 part, Herba Clinopodii Polycephali 13-16 part, Flos Hibisci 19-23 part, Herba pimpinellae diversifoliae 9-13 part, Ramulus Salicis Babylonicae 13-17 part, Herba Centellae 14-18 part, Herba Bryophylli Pinnati 16-23 part, Herba Liparidis nervosae 11-15 part, Herba Hyperici 18-25 part, Folium Agaves variegatae 16-23 part, Radix seu Folium callicarpae arboreae 11-17 part, Cacumen Platycladi 16-20 part, Rhizoma Imperatae 11-15 part, Herba balanophorae involucratae 9-15 part, Radix et Caulis Opuntiae Dillenii 15-19 part, Cortex Ulmi Parvifoliae 16-23 part, Herba Polygoni Capitati 12-16 part, Herba Cynanchi Thesioidis 11-17 part, Radix Stephaniae Tetrandrae 9-13 part, Radix Rubiae 11-17 part, Herba Camptosori Sibirici 15-18 part, unmrellaleaf 6-9 part, Folium Aucubae chinensis root 12-16 part, excellent careless 14-19 part, Radix Ophiopogonis 16-18 part, Radix Changii 17-20 part, Rhizoma Atractylodis Macrocephalae 14-18 part, Radix Fici beecheyanae 16-19 part and Radix Glycyrrhizae 17-21 part.

4. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 11 parts, Radix Et Rhizoma Fagopyri Tatarici 9 parts, Rhizoma Smilacis Chinensis 19 parts, Herba Ocimi (Herba Ocimi Pilosi) 12 parts, Rhizoma Bolbostematis 14 parts, Herba Clinopodii Polycephali 16 parts, Flos Hibisci 21 parts, Herba pimpinellae diversifoliae 9 parts, Ramulus Salicis Babylonicae 17 parts, Herba Centellae 15 parts, Herba Bryophylli Pinnati 16 parts, Herba Liparidis nervosae 15 parts, Herba Hyperici 25 parts, Folium Agaves variegatae 18 parts, Radix seu Folium callicarpae arboreae 11 parts, Cacumen Platycladi 20 parts, Rhizoma Imperatae 11 parts, Herba balanophorae involucratae 13 parts, Radix et Caulis Opuntiae Dillenii 15 parts, Cortex Ulmi Parvifoliae 23 parts, Herba Polygoni Capitati 13 parts, Herba Cynanchi Thesioidis 11 parts, Radix Stephaniae Tetrandrae 13 parts, 14 parts, Radix Rubiae, Herba Camptosori Sibirici 15 parts, unmrellaleaf 6 parts, Folium Aucubae chinensis root 16 parts, rod rod grass 16 parts, Radix Ophiopogonis 17 parts, Radix Changii 20 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Radix Fici beecheyanae 19 parts and 17 parts, Radix Glycyrrhizae.

5. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 12 parts, Radix Et Rhizoma Fagopyri Tatarici 8 parts, Rhizoma Smilacis Chinensis 17 parts, Herba Ocimi (Herba Ocimi Pilosi) 15 parts, Rhizoma Bolbostematis 11 parts, Herba Clinopodii Polycephali 15 parts, Flos Hibisci 23 parts, Herba pimpinellae diversifoliae 12 parts, Ramulus Salicis Babylonicae 15 parts, Herba Centellae 18 parts, Herba Bryophylli Pinnati 16 parts, Herba Liparidis nervosae 13 parts, Herba Hyperici 18 parts, Folium Agaves variegatae 16 parts, Radix seu Folium callicarpae arboreae 17 parts, Cacumen Platycladi 19 parts, Rhizoma Imperatae 13 parts, Herba balanophorae involucratae 15 parts, Radix et Caulis Opuntiae Dillenii 17 parts, Cortex Ulmi Parvifoliae 18 parts, Herba Polygoni Capitati 12 parts, Herba Cynanchi Thesioidis 15 parts, Radix Stephaniae Tetrandrae 11 parts, 11 parts, Radix Rubiae, Herba Camptosori Sibirici 18 parts, unmrellaleaf 7 parts, Folium Aucubae chinensis root 13 parts, rod rod grass 14 parts, Radix Ophiopogonis 16 parts, Radix Changii 17 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Radix Fici beecheyanae 18 parts and 19 parts, Radix Glycyrrhizae.

6. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described endo-medicine, the ratio of weight and number of each raw medicinal material is: Herba Houttuyniae 15 parts, Radix Et Rhizoma Fagopyri Tatarici 6 parts, Rhizoma Smilacis Chinensis 21 parts, Herba Ocimi (Herba Ocimi Pilosi) 13 parts, Rhizoma Bolbostematis 13 parts, Herba Clinopodii Polycephali 13 parts, Flos Hibisci 19 parts, Herba pimpinellae diversifoliae 13 parts, Ramulus Salicis Babylonicae 13 parts, Herba Centellae 14 parts, Herba Bryophylli Pinnati 21 parts, Herba Liparidis nervosae 11 parts, Herba Hyperici 23 parts, Folium Agaves variegatae 23 parts, Radix seu Folium callicarpae arboreae 15 parts, Cacumen Platycladi 20 parts, Rhizoma Imperatae 11 parts, Herba balanophorae involucratae 9 parts, Radix et Caulis Opuntiae Dillenii 19 parts, Cortex Ulmi Parvifoliae 16 parts, Herba Polygoni Capitati 16 parts, Herba Cynanchi Thesioidis 17 parts, Radix Stephaniae Tetrandrae 9 parts, 17 parts, Radix Rubiae, Herba Camptosori Sibirici 16 parts, unmrellaleaf 9 parts, Folium Aucubae chinensis root 12 parts, rod rod grass 19 parts, Radix Ophiopogonis 18 parts, Radix Changii 19 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Radix Fici beecheyanae 16 parts and 21 parts, Radix Glycyrrhizae.

7., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is ointment, its preparation method comprises the following steps:

Described raw medicinal material is soaked 1-2 hour in described ratio mixing, is then placed in multi-function extractor, first time decocts 5-10 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, cooling, tinning after ultraviolet radiation sterilizing.

8., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is liniment, its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds coarse powder 8-10 times amount soak by water 1-3 hour, and second time adds coarse powder 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in the glycerol accounting for a and b mixture gross mass 10% after being mixed with fine powder b by fine powder a and make liniment.

9., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is spray, its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, 80-160 order filters, get 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

10., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.