CN104971315A - Antibacterial gel for treating injury wound infection and preparation method of antibacterial gel - Google Patents
Antibacterial gel for treating injury wound infection and preparation method of antibacterial gel Download PDFInfo
- Publication number
- CN104971315A CN104971315A CN201510425600.7A CN201510425600A CN104971315A CN 104971315 A CN104971315 A CN 104971315A CN 201510425600 A CN201510425600 A CN 201510425600A CN 104971315 A CN104971315 A CN 104971315A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- rhizoma
- radix
- herba
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Abstract
The invention provides antibacterial gel for treating injury wound infection and a preparation method of the antibacterial gel. The gel is prepared from the following crude medicinal materials: rhizoma cimicifugae, radix bupleuri, puffball, astragalus, bistort rhizome, rhizoma bletillae, olibanum, myrrh, dragon blood, acacia catechu, rhizoma sparganii, curcuma zedoary, cinnamon, semen brassicae, Chinese yams, honey, white atractylodes rhizome, copperleaf herbs, herba pteridis multifidae, ilex nitidissima, crucian carp galls, apluda mutica, sunset abelmoschus seeds, pendulous monkshood roots, wilson passionflower herbs, radix ranunculi ternati, four-leaf clovers and guaijiaoqi. The antibacterial gel is based on the therapeutic principles of clearing away heat and toxic materials as well as relieving swelling and expelling pus and also has the effects of dispelling putrefactions, promoting blood circulation to remove meridian obstruction as well as removing blood stasis and promoting tissue regeneration. Meanwhile, the immunity of a human body can be enhanced, the antibacterial gel has the characteristics of pure natural property, no hazards, safety, convenience, comprehensive function, simple and convenient manufacturing process and low toxic or side effects on the aspect of treating wound infection and is convenient to dose, relatively good in curative effect, relatively good in tolerance, easy to accept and manufacture and low in cost.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind ofly treating antibacterial gel that traumatic surface infects and preparation method thereof.
Background technology
Wound is classified: 1. clean wound 2. cleans contaminated wound 3. contaminated wound 4. infected wound.
Various wound, usually causes the damage of skin and soft tissue, even severed limb time serious.Treatment of wounds is correct, and it can be made to heal rapidly; Otherwise possible suppurative infection, does not prolongedly heal, even because of threat to life such as concurrent systemic infection, gas gangrene, tetanus.Therefore, for the wound of wound, strictly conscientious process must be carried out.Human body, once suffer wound, if process wound not in time, just easily makes wound infection.
The principle of process wound is: 1, hemostasis 2, wrapping.
Treatment step: 1, clean wound 2, hemostasis 3, anthemorrhagic difficulty, uses binder 4, process blood crusts.
Wound healing divides three classes: primary healing, secondary healing and the healing of three phases.The concept of primary healing is that edge of wound does not have not stay dead space in cavity or wound close to closing.Such as surgical incision inorganization defect, clean lacerated wound; The concept of secondary healing is that wound is open, sees tissue and goes to pot or organize loss; The healing of three phases is the first secondary closure be delayed by.
(1) the inflammatory reaction stage of inflammatory stage wound healing, its sign is that local temperature increases, rubescent, swelling, and the function in this stage removes dead antibacterial and cell, Promotive union process.This reaction at first starts a series of interaction, the triggering center of response stimulus health.
(2) proliferative phase proliferative phase is also called proliferative phase, and 48 hours after wound start.This phase with fibroblastic activity for feature.Macrophage and platelet stimulate fibroblast to produce.5 ~ 6 days after wound, during application Vitamin C, fibroblast started to synthesize collagen protein and supports cambium substrate.Within 2 ~ 3 weeks, produce quick collagen protein synthesis.
(3) the variation stage variation stage is named again the plastotype phase again, and after wound about 21 days start.Interim at this, fibroblast number reduces, and collagen protein continues adhesion, changes model, forms cicatrix, and show ripe sign obvious, cicatrix becomes scarlet about 4 months, redness of then decorporating gradually, finally becomes silvery white.
Influence factor: wound healing is very complicated under physiological conditions, and affect by multiple internal and external factor, it includes infection simultaneously, steroid therapy, malnutrition, the internal disease occurred together is as diabetes, and the factor that local blood supply is reduced.At different conditions, wound healing may be accelerated the time that is very poor or healing greatly.
Wound is in agglutination in sum, and paranormal time span just can not accelerate healing, and some factor such as malnutrition, infection, wound and diagnostic get the healing time that tissue etc. can weaken wound.When having the wound healing process that infects and merge or usually decide surgical repair wound by surgeon nursing care plan, requirement is nursed.Correct malnutrition situation, control diabetes, improve anemia, fluid infusion makes tissue keep good perfusion then, is contribute to the optimum state that healing occurs wound.
Points for attention
1. when bathing a wound, patient should keep relaxed state as far as possible, disperses its attention;
2. wound has pain person, can take analgesic or spray pain-relieving powder for treating before clean wound;
3. the wound person that has pus, with two cotton balls as far as possible by clean for it extruding;
4. wound has bleeder, slightly can exert pressure, to help hemostasis at hemorrhage place;
5. festering property wound foul smelling, indicates slough, and such as tissue has slough, can first use tap water high pressure rinse, at clean wound, is removed by slough as far as possible, then covers active carbon dressing, to help absorption stink;
If 6. have tunnel or fistula in wound, should clog with gauze kerchief, to help extraction sepage;
7. when wound gradually heals, the crust hypertrophy of visible dermis, now applies Lipido-colloid dressing, in case during removing dressing, hinder skin healing
Treatment: remove slough, cicatrix, outmoded granulation tissue, foreign body etc., until the tissue that relative healths, blood fortune is abundant.Need row Vessel Skin Flap person for the chronic ulcer exposed with bone, joint etc., the quality of Wound treatment is skin flap transplantation successfully one of key.Soak with hydrogen peroxide, benzalkonium bromide, normal saline, povidone iodine and rinse 5min respectively.Povidone-Iodine Solution gauze covers, local edema severe patient, with 3% hypertonic saline soak, or root Ju antibacterial, fungal culture and check result, add with antibiotic and antifungal agent.Western medicine: on the one hand, toxic and side effects is larger, may cause other side effect, on the other hand, is also unfavorable for the good recovery of patient's wound.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of gel and preparation method thereof for the treatment of traumatic surface and infecting, the present invention dispels pus for Therapeutic Principle with heat-clearing and toxic substances removing, detumescence, holds concurrently with putrefaction removing, promoting blood circulation to remove obstruction in the collateral, blood stasis dispelling granulation promoting.Meanwhile, the immunity of people can be improved, there is pure natural property in treatment traumatic infection, nonhazardous, safe ready, complete function, processing technology are easy, the feature that toxic and side effects is little, good effect, instant effect, and convenient drug administration, curative effect is better, and toleration is better, is easy to accept; Medicament is easy to manufacture, with low cost.
The invention provides a kind of gel for the treatment of traumatic surface and infecting, wherein, described gel is obtained by following raw medicinal material: Rhizoma Cimicifugae, Radix Bupleuri, Lasiosphaera Seu Calvatia, the Radix Astragali, Rhizoma Bistortae, Pseudobulbus Bletillae (Rhizoma Bletillae), Olibanum, Myrrha, Sanguis Draxonis, catechu, Rhizoma Sparganii, Rhizoma Curcumae, Cortex Cinnamomi, Semen Sinapis Albae, Rhizoma Dioscoreae, Mel, the Rhizoma Atractylodis Macrocephalae, Herba Acalyphae, Herba Pteridis Multifidae, Ilex viridis Champ., Fel Carassius auratus, Radix Apludate Muticae, Semen abelmoschi manihot, Radix aconiti szechenyiani, Herba Passiflorae Wilsonii, Radix Ranunculi Ternati, Herba Galii Bungei and turning seven.
Wherein, described gel is obtained by the raw medicinal material of following weight portion: Rhizoma Cimicifugae 10-20 weight portion, Radix Bupleuri 8-12 weight portion, Lasiosphaera Seu Calvatia 3-5 weight portion, Radix Astragali 15-20 weight portion, Rhizoma Bistortae 12-25 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-14 weight portion, Olibanum 8-12 weight portion, Myrrha 4-8 weight portion, Sanguis Draxonis 3-7 weight portion, catechu 5-9 weight portion, Rhizoma Sparganii 10-14 weight portion, Rhizoma Curcumae 3-6 weight portion, Cortex Cinnamomi 10-20 weight portion, Semen Sinapis Albae 15-20 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Mel 3-7 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Herba Acalyphae 4-9 weight portion, Herba Pteridis Multifidae 10-20 weight portion, Ilex viridis Champ. 15-25 weight portion, Fel Carassius auratus 4-8 weight portion, Radix Apludate Muticae 10-20 weight portion, Semen abelmoschi manihot 14-22 weight portion, Radix aconiti szechenyiani 2-4 weight portion, Herba Passiflorae Wilsonii 10-20 weight portion, Radix Ranunculi Ternati 10-20 weight portion, Herba Galii Bungei 15-20 weight portion and turning seven 2-5 weight portion.
Wherein, described gel is obtained by the raw medicinal material of following weight portion: Rhizoma Cimicifugae 15-20 weight portion, Radix Bupleuri 8-12 weight portion, Lasiosphaera Seu Calvatia 3-5 weight portion, Radix Astragali 15-20 weight portion, Rhizoma Bistortae 12-20 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-14 weight portion, Olibanum 8-12 weight portion, Myrrha 4-8 weight portion, Sanguis Draxonis 3-7 weight portion, catechu 5-9 weight portion, Rhizoma Sparganii 10-14 weight portion, Rhizoma Curcumae 3-6 weight portion, Cortex Cinnamomi 15-20 weight portion, Semen Sinapis Albae 15-20 weight portion, Rhizoma Dioscoreae 15-20 weight portion, Mel 3-7 weight portion, Rhizoma Atractylodis Macrocephalae 10-15 weight portion, Herba Acalyphae 4-9 weight portion, Herba Pteridis Multifidae 15-20 weight portion, Ilex viridis Champ. 15-20 weight portion, Fel Carassius auratus 4-8 weight portion, Radix Apludate Muticae 15-20 weight portion, Semen abelmoschi manihot 14-22 weight portion, Radix aconiti szechenyiani 2-4 weight portion, Herba Passiflorae Wilsonii 15-20 weight portion, Radix Ranunculi Ternati 10-15 weight portion, Herba Galii Bungei 15-20 weight portion and turning seven 2-5 weight portion.
Wherein, described gel is obtained by the raw medicinal material of following weight portion: Rhizoma Cimicifugae 16 weight portion, Radix Bupleuri 9 weight portion, Lasiosphaera Seu Calvatia 4 weight portion, the Radix Astragali 18 weight portion, Rhizoma Bistortae 22 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 weight portion, Olibanum 10 weight portion, Myrrha 5 weight portion, Sanguis Draxonis 6 weight portion, catechu 6 weight portion, Rhizoma Sparganii 12 weight portion, Rhizoma Curcumae 5 weight portion, Cortex Cinnamomi 12 weight portion, Semen Sinapis Albae 16 weight portion, Rhizoma Dioscoreae 18 weight portion, Mel 4 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Herba Acalyphae 5 weight portion, Herba Pteridis Multifidae 12 weight portion, Ilex viridis Champ. 18 weight portion, Fel Carassius auratus 5 weight portion, Radix Apludate Muticae 16 weight portion, Semen abelmoschi manihot 16 weight portion, Radix aconiti szechenyiani 3 weight portion, Herba Passiflorae Wilsonii 16 weight portion, Radix Ranunculi Ternati 16 weight portion, Herba Galii Bungei 17 weight portion and turning 73 weight portion.
Wherein, described gel is obtained by the raw medicinal material of following weight portion: Rhizoma Cimicifugae 16 weight portion, Radix Bupleuri 9 weight portion, Lasiosphaera Seu Calvatia 4 weight portion, the Radix Astragali 16 weight portion, Rhizoma Bistortae 15 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 weight portion, Olibanum 10 weight portion, Myrrha 6 weight portion, Sanguis Draxonis 5 weight portion, catechu 6 weight portion, Rhizoma Sparganii 12 weight portion, Rhizoma Curcumae 5 weight portion, Cortex Cinnamomi 16 weight portion, Semen Sinapis Albae 16 weight portion, Rhizoma Dioscoreae 16 weight portion, Mel 5 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Herba Acalyphae 5 weight portion, Herba Pteridis Multifidae 18 weight portion, Ilex viridis Champ. 15 weight portion, Fel Carassius auratus 5 weight portion, Radix Apludate Muticae 16 weight portion, Semen abelmoschi manihot 16 weight portion, Radix aconiti szechenyiani 3 weight portion, Herba Passiflorae Wilsonii 16 weight portion, Radix Ranunculi Ternati 12 weight portion, Herba Galii Bungei 16 weight portion and turning 73 weight portion.
In order to solve the problem, present invention also offers the preparation method of described gel, wherein, its preparation method comprises the following steps:
The first step: get described raw medicinal material and add water extraction 1-2 time, extracting solution is condensed into extractum shape, be component 1, medicinal residues are for subsequent use;
Second step: the medicinal residues first step obtained add 82-90% soak with ethanol 1.0-1.5 hour, extract twice, each 1 hour, merge extractive liquid, filter, concentrated, 135-170 order filter, 6200-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5300-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 96 DEG C 1.30 extractum, heating and refluxing extraction 2 times, each 45-50 minute, extracts active ingredient, 2 extracting solution are merged and is settled into extractum shape, as component 2;
3rd step: component 1 and component 2 are mixed, adds mixing by the sodium carboxymethyl cellulose of mixture 0.1-0.5 times amount and the water of 1-2 times amount, under the high-speed stirred of agitator, concentrates and obtains gel.
For solving the problems of the technologies described above, the present invention also provides a kind of medicine for the treatment of traumatic surface and infecting, wherein, pharmaceutical dosage form can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, hard gel agent, syrup, powder, enema and patch.
The invention has the beneficial effects as follows: the present invention dispels pus for Therapeutic Principle with heat-clearing and toxic substances removing, detumescence, holds concurrently with putrefaction removing, promoting blood circulation to remove obstruction in the collateral, blood stasis dispelling granulation promoting.Meanwhile, the immunity of people can be improved, there is pure natural property in treatment traumatic infection, nonhazardous, safe ready, complete function, processing technology are easy, the feature that toxic and side effects is little, good effect, instant effect, and convenient drug administration, curative effect is better, and toleration is better, is easy to accept; Medicament is easy to manufacture, with low cost.
Detailed description of the invention
In order to solve the problem, the invention provides a kind of antibacterial gel for the treatment of traumatic surface and infecting, the present invention dispels pus for Therapeutic Principle with heat-clearing and toxic substances removing, detumescence, hold concurrently with putrefaction removing, promoting blood circulation to remove obstruction in the collateral, blood stasis dispelling granulation promoting, obtained by following raw medicinal material: Rhizoma Cimicifugae, Radix Bupleuri, Lasiosphaera Seu Calvatia, the Radix Astragali, Rhizoma Bistortae, Pseudobulbus Bletillae (Rhizoma Bletillae), Olibanum, Myrrha, Sanguis Draxonis, catechu, Rhizoma Sparganii, Rhizoma Curcumae, Cortex Cinnamomi, Semen Sinapis Albae, Rhizoma Dioscoreae, Mel, the Rhizoma Atractylodis Macrocephalae, Herba Acalyphae, Herba Pteridis Multifidae, Ilex viridis Champ., Fel Carassius auratus, Radix Apludate Muticae, Semen abelmoschi manihot, Radix aconiti szechenyiani, Herba Passiflorae Wilsonii, Radix Ranunculi Ternati, Herba Galii Bungei and turning seven.
Wherein, Lasiosphaera Seu Calvatia, Herba Acalyphae, Herba Pteridis Multifidae, Ilex viridis Champ., Fel Carassius auratus, Radix Apludate Muticae heat-clearing and toxic substances removing, disappear pus putrefaction removing; Pseudobulbus Bletillae (Rhizoma Bletillae), Olibanum, Myrrha, Sanguis Draxonis, catechu, Rhizoma Sparganii, Rhizoma Curcumae, Semen abelmoschi manihot, Radix aconiti szechenyiani, Herba Passiflorae Wilsonii blood circulation promoting and blood stasis dispelling granulation promoting, eliminate blood stasis band thrombosis, fresh blood gone directly flesh table, promotes wound healing; Rhizoma Dioscoreae is nourished blood yin nourishing, holds concurrently to invigorate blood circulation; Rhizoma Cimicifugae, Radix Bupleuri vital energy regualting and blood circulation-promoting; Cortex Cinnamomi, Semen Sinapis Albae, Rhizoma Atractylodis Macrocephalae warming YANG, prevent the stasis of blood of each medicine stagnant; Radix Ranunculi Ternati, Herba Galii Bungei and turning seven reducing swelling and alleviating pain; Pseudobulbus Bletillae (Rhizoma Bletillae), Mel cuticula, prevent the scorching factor of extraneous system from invading further.Various medical material scientific matching, realize Scientific Treatment traumatic infection, curative effect is better.
The pharmacological property of each raw medicinal material is as follows:
Rhizoma Cimicifugae: acrid in the mouth, sweet, cold nature; Return lung meridian, spleen channel, large intestine channel, stomach warp.Heat-clearing and toxic substances removing, rash, ascending up spleen-Qi and Yang." property of medicine opinion ": " control little eclampsia, infantile convulsion, the hot disease of seasonal epidemic pathogens.Can control the swollen pain of ability to speak wind NI, root of the tooth floats rotten stench, pyretic toxicity pus and blood.Except cardiopulmonary pathogenic wind toxic heat is obstructed and constipated, aphtha, unhappy.Treat carbuncle, smallpox; Decocting silk floss is stained with and is wiped in skin ulcer." Compendium of Material Medica: " speckle removing rash, clots absorbing blood are controlled sun and are fallen into dizzy fortune, the empty pain of the breast side of body, heavy after chronic diarrhea dysentery, lose turbid, leukorrhagia, metrorrhagia, stranguria with blood, hematochezia, impotence cold foot." function heat-clearing and toxic substances removing, rash.Not smooth, maculopapulae due to toxic heat, diseases caused by exogenous pathogenic factor exterior syndrome is thoroughly sent out, weight, women's leukorrhagia, metrorrhagia under epidemic disease fire-toxin, aphtha, pharyngalgia, headache cold and heat, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, chronic dysentery for measles.
Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire.Function: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly: the heating that cures cold, cold and heat deficient fever.Children's's varioliform exanthema waste heat, emaciation and sallow complexion abdominal part expands, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, and uterus comes off, menoxenia.
The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Air making-up and spleen enlivening, benefit defends real table, ascending up spleen-Qi and Yang, poison holding sore, inducing diuresis to remove edema.Essentials of Matea Medica: " Radix Astragali, life consolidating superficial resistance losslessly can be sent out, and have antiperspirant to stop; Process with invigorating middle warmer, beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person.”
Rhizoma Bistortae: bitter, cool; Return lung, liver, large intestine channel.Heat clearing away is relieving convulsion, the wet detumescence of reason.Control that calentura is frightened jerks, tetanus, bloody dysentery, carbuncle, scrofula." modern Practical Chinese medicinal ": " take orally and control bloody dysentery; Rinsing the mouth makes the astringent of stomatitis; Hemorrhoid and abscess are controlled in external." " Chinese medicinal herbal ": " heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Control calentura infantile convulsion, tetany, tetanus, carbuncle scrofula, snake bite and insect sting." heat clearing away is relieving convulsion, the wet detumescence of reason.
Pseudobulbus Bletillae (Rhizoma Bletillae): property is bitter, sweet, puckery, cold nature, enters lung, stomach, Liver Channel, astringing to arrest bleeding, detumescence and promoting granulation." Japan hanako materia medica ": " spasmolytic is evil, blood is evil, and dysentery, acute conjunctivitis, crux, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid wart, cutter arrow skin ulcer flutters damage, warm malaria, dysentery, sore due to scald and burn, granulation promoting pain relieving, migratory arthralgia." " Bencao Tujing ": " is controlled incised wound and is not recovered, in carbuncle side multiplex it." there is the effect of astringing to arrest bleeding, detumescence and promoting granulation, be mainly used in the deficiency of the lung, pulmonary tuberculosis, the hemoptysis of yin asthenia generating intrinsic heat, the haematemesis of thermal burn stomach network; The cards such as traumatic hemorrhage, Pseudobulbus Bletillae (Rhizoma Bletillae) has and promotes erythrocyte aggregation and local hemostaticly to rent have anastalsis to gastric duodenal ulcer is hemorrhage.
Olibanum: pungent, bitter, temperature.Enter the heart, liver, spleen channel.Removing stasis to stop bleeding, promoting blood circulation and stopping pain granulation promoting.Supplement to the Herbal: " treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooled, and only large intestine lets out Bleach, treats all skin ulcers and makes internal diabetes." Compendium of Material Medica: " all poison of eliminating carbuncle cellulitis, the heart is protected in Tuoli, and analgesic therapy of invigorating blood circulation, stretches muscle, controls married woman's difficult labour, injured." regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Myrrha: acrid in the mouth, hardship, property is put down, and GUIXIN, liver, spleen channel, have dissipating blood stasis analgesic therapy, and effect of detumescence and promoting granulation, cures mainly obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, rheumatic arthralgia, traumatic injury, the cards such as carbuncle skin infection.
Sanguis Draxonis: sweet in the mouth, salty, property are flat, mild toxicity.GUIXIN warp, Liver Channel.The analgesic therapy of function dissipating blood stasis, hemostasis, promoting tissue regeneration and ulcer healing.Cure mainly traumatic injury, ecchymoma due to internal injury, dysmenorrhea, postpartum stagnation is suffered from abdominal pain, continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time and hemorrhoid.
Catechu: bitter in the mouth, puckery, cold nature, returns lung meridian, has effect of removing dampness promoting tissue regeneration and ulcer healing, and for ulcer being unable to heal, eczema, aphtha, falls and flutter the pain of injury, the cards such as traumatic hemorrhage.Contained by these product, d-cachou extract and epicatechin all have remarkable hepatoprotective effect.
Rhizoma Sparganii: acrid, bitter, warm, returns liver, spleen two warp, removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Compendium of Material Medica: " Rhizoma Sparganii energy relieving stagnant and resolving masses, therefore all diseases can be controlled, its merit can be bordering on Rhizoma Cyperi and power is high, therefore difficult clothes for a long time." be applicable to kinds of tumors, as ovarian cancer, cervical cancer, hepatocarcinoma etc.
Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.This product effect is similar to Rhizoma Sparganii, removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.But warm concerted effort is comparatively large, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.Can the pain relieving of circulation of qi promoting removing food stagnancy, for eating accumulation, breast abdominal distention is vexed has a pain.
Cortex Cinnamomi: also known as Cortex cinnamomi japonici (Ramulus Cinnamomi).Extremely hot in nature, acrid in the mouth, sweet, return kidney, spleen, the heart, Liver Channel, have that to mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, effect of promoting blood circulation to restore menstrual flow, for warming the spleen and stomach, removing accumulated cold, promoting blood circulation." property of medicine opinion ": " cure mainly nine types of precordial pain, kill three worms, main removing blood stasis, the tonneau moon closes, and controls weak foot, numbness, meciless, retention of placenta, and except cough with dyspnea, stagnation of QI, gather around numbness, only cold air in abdomen, unbearably painful, main dysentery, nasal polyp.Herbicide wood poison." " Japan hanako materia medica ": " control all pathogenic wind, mend five kinds of strain and seven kinds of impairment, logical nine orifices, sharp joint, benefit essence, improving eyesight, warm waist knee joint, broken mass beside the umbilicus lump in the abdomen, repercussive blood, controls migratory arthralgia joint contracture, reuniting the fractured tendons and bones, granulation promoting meat." have mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, effect of promoting blood circulation to restore menstrual flow, for warming the spleen and stomach, removing accumulated cold, promoting blood circulation.
Semen Sinapis Albae: acrid in the mouth, temperature, nontoxic.Enter the warp of liver, spleen, lung, stomach, the heart and collaterals of the uterus.Can remove cold air, settling five organs, by the expectorant of film diaphragm, ward off stealthy gas, the addiction that disappears malaria, drop interests Dingchuan, sharp key improving eyesight, and removing blood stasis relieves the pain, and all can prove effective.Can energy dissipating fall, energy complementary energy liter, helps all tonics, outstanding kind receipts merit." Japan hanako materia medica ": " control the swollen and paralysis of pathogenic wind toxic, vinegar grind Fu it.Flutter damage blood stasis, lumbago kidney cold-peace Rhizoma Zingiberis Recens grinds, micro-warm, is coated with and pastes.Pained, wine vinegar takes it." Compendium of Material Medica: " Semen Sinapis Albae is pungent can enter lung, and temperature can be dispersed, therefore has the merit of the appetizing of promoting the circulation of QI eliminating phlegm, warming middle-JIAO, loose evil of bitterly subsiding a swelling, ward off." cold air can be removed, settling five organs, by the expectorant of film diaphragm, ward off stealthy gas, the addiction that disappears malaria, drop interests Dingchuan, sharp key improving eyesight, and removing blood stasis relieves the pain, and all can prove effective.Can energy dissipating fall, energy complementary energy liter, helps all tonics, outstanding kind receipts merit.
Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red card such as swollen, fat of frequent micturition of quenching one's thirst, premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Mel: sweet in the mouth, property are flat.Spleen, stomach, lung, large intestine channel.Loosening bowel to relieve constipation, removing toxic substances.Mel also has certain curative effect to some chronic disease.Informal dress Mel has good medical assistance effect for heart disease, hypertension, pneumonopathy, oculopathy, hepatopathy, dysentery, constipation, anemia, nervous system disease, gastric duodenal ulcer disease etc.The several years at room temperature placed by high-quality Mel can not be corrupt, shows that its antisepsis is extremely strong.Experiment confirms, Mel has stronger inhibitory action to gram positive bacterias such as streptococcus, staphylococcus, diphtheria.Research proves, Mel has regulating action to gastrointestinal function, and gastric acid secretion can be made normal.Zoopery confirms, Mel has the effect strengthening enterokinesia, significantly can shorten defecation time.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, has regulating action to gastrointestinal function.
Herba Acalyphae: bitter, puckery, cool.Return lung, liver, large intestine channel, heat-clearing and toxic substances removing, dampness removing, astringing to arrest bleeding." Heilungkiang Chinese medicine ": " for menoxenia, women's disorders of blood." for enteritis, dysentery, haematemesis, epistaxis, have blood in stool, hematuria, metrorrhagia, carbuncle furuncle infections, skin eczema.Rich in proteins, fat in Herba Acalyphae.Saccharide and multivitamin and mineral, the protein contained by it more can fully be absorbed by the body than milk, and contained carotene is higher than solanaceous vegetables more than 2 times, can be the nutrient substance that human body provides abundant, be conducive to building body, improve the immunity of body, have the title of " longevity greens/mustard green ".Herba Acalyphae can promote the growth promoter of children's, has certain food therapy value to the healing of fracture.
Herba Pteridis Multifidae: light, micro-hardship is cool.Return lung, large intestine channel.Clearing away heat-damp and promoting diuresis, removing toxic substances dysentery relieving, cooling blood for hemostasis.For dysentery, gastroenteritis, hepatitis, urinary system infection, cat fever, laryngopharynx swelling and pain, leucorrhea, metrorrhagia, pesticide intoxication; Traumatic hemorrhage is controlled in external, burn and scald." the SHENGCAO property of medicine is standby to be wanted ": " wash infantile malnutrition, furuncle, hemorrhoid, loose poison, applies skin ulcer.Control Serpentis and sting all poison, knife injury, energy hemostasia and promoting granulation, spring juice rectification clothes, slag applies affected part.Grinding into powder harvests and store controls pain due to disorder of QI." " conventional Chinese herbal medicine handbook ": " heat clearing away, dampness removing, removing heat from blood.Control bacillary dysentery, enteritis, fever caused by exogenous pathogens, urinary tract infection, leucorrhea, parotitis, furuncle, eczema.”
Ilex viridis Champ.: habitats distribution East China, Guangdong.[nature and flavor] are sweet, micro-pungent, cool.[function cures mainly] removing pathogenic heat from blood and toxic substance from the body, putrefaction removing and tissue regeneration promoting.
Fel Carassius auratus: [nature and flavor] are bitter, flat.[function cures mainly] synthetism is subsided a swelling, granulation promoting putrefaction removing.Control traumatic injury knife injury, furuncle.
Radix Apludate Muticae: [habitats distribution] ecological environment: be grown on woods limit, hedge limit, open spacious meadow or riverbank.Resource distribution: be distributed in south China, southwestern various places.[function cures mainly] putrefaction removing detoxifies; Tonifying YANG.Main lower limb fester; Snake bite and insect sting.
Semen abelmoschi manihot: [nature and flavor] are sweet, cold, sliding.1. " detailed outline ": " sweet, cold, sliding, nontoxic." 2. " Shaanxi Chinese herbal medicine ": " is sweet, flat." [function cures mainly] diuretic, detumescence, lactogenesis.Control gonorrhea, edema, galactostasis, carbuncle, injury from falling down, fracture.1. " Bencao Tujing ": " main pouring is puckery, makes again married woman easily produce." 2. " detailed outline ": " controls carbuncle, diuresis, five types of stranguria edema, dystocia, promoting lactation." 3. " Shaanxi Chinese herbal medicine ": " spleen reinforcing stomach invigorating, granulation promoting.Control dyspepsia, anorexia, traumatic injury, fracture."
Radix aconiti szechenyiani: [nature and flavor] are bitter, pungent, temperature.[function cures mainly] wind-expelling pain-stopping, dissipating blood stasis stops blooding, detumescence and drawing out poison.For rheumatic arthritis, lumbago and skelalgia, traumatic injury; Tuberculous lymphadenitis (not breaking) is controlled in external, carbuncle pyogenic infections from tumour or sore.
Herba Passiflorae Wilsonii: [nature and flavor] micro-hardship, temperature.1. " choosing of Yunnan Chinese herbal medicine ": " micro-hardship, temperature." 2. " choosing of Simao, Yunnan Chinese herbal medicine ": " is lightly seasoned, warm in nature." [function cures mainly] relaxing muscles and tendons to promote blood circulation, removing dampness and killing parasites.Treating rheumatic arthritis, injury and bone fracture, hepatitis.Malaria, ascariasis.
Radix Ranunculi Ternati: nature and flavor sweet, acrid, warm.[return through] returns liver, lung meridian.[function cures mainly] eliminating stagnation, detumescence., tuberculous lymphadenitis not routed for scrofula.
Herba Galii Bungei: [nature and flavor] " Jiangxi medical herbs ": " sweet, flat." [function cures mainly] heat clearing away, diuresis, removing toxic substances, detumescence.Control urinary tract infection, leucorrhea with red and white discharge, dysentery, carbuncle, traumatic injury.1. " Jiangxi medical herbs ": " heat-clearing and toxic substances removing; Reducing swelling and alleviating pain, tonneau urine." doctor that 2. revives " Chinese herbal medicine handbook ": " inducing diuresis to remove edema, anticancer.Control urinary tract infection, leucorrhea with red and white discharge, cervical erosion, suppurative inflammation, and control cerebrospinal meningitis, septic septicemia, carbuncle, venom, skin sore edema, cancerous protuberance."
Turning seven: [nature and flavor] toil, cool.1. " Shaanxi Chinese herbal medicine ": " bitter, cool." 2. " Chinese herbal medicine is commonly used in Sichuan ": " toil, temperature." [return through] " Chinese herbal medicine is commonly used in Sichuan ": " enters lung, spleen two warp." [function cures mainly] parasite killing, eliminate indigestion, detumescence, dissipating blood stasis.Control stubborn dermatitis, tinea alba, malaria, infantile malnutrition, dysentery, carbuncle furuncle swells, scrofula, traumatic injury.
Described antibacterial gel is only obtained by above-mentioned raw materials medical material.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 gel 1
Formula is: Rhizoma Cimicifugae 16 parts, Radix Bupleuri 9 parts, Lasiosphaera Seu Calvatia 4 parts, the Radix Astragali 18 parts, Rhizoma Bistortae 22 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 parts, Olibanum 10 parts, Myrrha 5 parts, Sanguis Draxonis 6 parts, 6 parts, catechu, Rhizoma Sparganii 12 parts, Rhizoma Curcumae 5 parts, Cortex Cinnamomi 12 parts, Semen Sinapis Albae 16 parts, Rhizoma Dioscoreae 18 parts, Mel 4 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Acalyphae 5 parts, Herba Pteridis Multifidae 12 parts, Ilex viridis Champ. 18 parts, Fel Carassius auratus 5 parts, Radix Apludate Muticae 16 parts, Semen abelmoschi manihot 16 parts, Radix aconiti szechenyiani 3 parts, Herba Passiflorae Wilsonii 16 parts, Radix Ranunculi Ternati 16 parts, Herba Galii Bungei 17 parts and 73 parts, turning.
Its preparation method is:
The first step: get described raw medicinal material and add water extraction 2 times, extracting solution is condensed into extractum shape, be component 1, medicinal residues are for subsequent use;
Second step: the medicinal residues first step obtained add 90% soak with ethanol 1.0 hours, extracts twice, each 1 hour, merge extractive liquid, filters, concentrated, 150 orders filter, 6200 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5300 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 96 DEG C 1.30 extractum, heating and refluxing extraction 2 times, each 45 minutes, extracts active ingredient, 2 extracting solution are merged and is settled into extractum shape, as component 2;
3rd step: component 1 and component 2 are mixed, adds mixing by the sodium carboxymethyl cellulose of mixture 0.1 times amount and the water of 1 times amount, under the high-speed stirred of agitator, concentrates and obtains gel.
Embodiment 2 gel 2
Formula is: Rhizoma Cimicifugae 16 parts, Radix Bupleuri 9 parts, Lasiosphaera Seu Calvatia 4 parts, the Radix Astragali 16 parts, Rhizoma Bistortae 15 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Olibanum 10 parts, Myrrha 6 parts, Sanguis Draxonis 5 parts, 6 parts, catechu, Rhizoma Sparganii 12 parts, Rhizoma Curcumae 5 parts, Cortex Cinnamomi 16 parts, Semen Sinapis Albae 16 parts, Rhizoma Dioscoreae 16 parts, Mel 5 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Herba Acalyphae 5 parts, Herba Pteridis Multifidae 18 parts, Ilex viridis Champ. 15 parts, Fel Carassius auratus 5 parts, Radix Apludate Muticae 16 parts, Semen abelmoschi manihot 16 parts, Radix aconiti szechenyiani 3 parts, Herba Passiflorae Wilsonii 16 parts, Radix Ranunculi Ternati 12 parts, Herba Galii Bungei 16 parts and 73 parts, turning.
Its preparation method is:
The first step: get described raw medicinal material and add water extraction 2 times, extracting solution is condensed into extractum shape, be component 1, medicinal residues are for subsequent use;
Second step: the medicinal residues first step obtained add 90% soak with ethanol 1.5 hours, extracts twice, each 1 hour, merge extractive liquid, filters, concentrated, 170 orders filter, 10000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 96 DEG C 1.30 extractum, heating and refluxing extraction 2 times, each 50 minutes, extracts active ingredient, 2 extracting solution are merged and is settled into extractum shape, as component 2;
3rd step: component 1 and component 2 are mixed, adds mixing by the sodium carboxymethyl cellulose of mixture 0.5 times amount and the water of 2 times amount, under the high-speed stirred of agitator, concentrates and obtains gel.
The agent of embodiment 3 paster
Formula is: Rhizoma Cimicifugae 10-20 part, Radix Bupleuri 8-12 part, Lasiosphaera Seu Calvatia 3-5 part, Radix Astragali 15-20 part, Rhizoma Bistortae 12-25 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-14 part, Olibanum 8-12 part, Myrrha 4-8 part, Sanguis Draxonis 3-7 part, catechu 5-9 part, Rhizoma Sparganii 10-14 part, Rhizoma Curcumae 3-6 part, Cortex Cinnamomi 10-20 part, Semen Sinapis Albae 15-20 part, Rhizoma Dioscoreae 15-25 part, Mel 3-7 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Herba Acalyphae 4-9 part, Herba Pteridis Multifidae 10-20 part, Ilex viridis Champ. 15-25 part, Fel Carassius auratus 4-8 part, Radix Apludate Muticae 10-20 part, Semen abelmoschi manihot 14-22 part, Radix aconiti szechenyiani 2-4 part, Herba Passiflorae Wilsonii 10-20 part, Radix Ranunculi Ternati 10-20 part, Herba Galii Bungei 15-20 part and turning seven 2-5 part.
Its preparation method is:
The first step, by Rhizoma Cimicifugae, Radix Bupleuri, Lasiosphaera Seu Calvatia, Radix Astragali mixing, with the dissolve with ethanol of the determining alcohol 85% of 4 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filtered, obtained the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% of 2 times relative to the mixture quality obtained, reflux was extracted after 1 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, by Rhizoma Curcumae, Cortex Cinnamomi, Semen Sinapis Albae, Rhizoma Dioscoreae mixing, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% of 3 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C 60 DEG C, relative density is the mastic of 1.20, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 times relative to the mixture quality obtained, and heating decoction 2 hours, filters; By filtering residue again with the water dissolution of 1 times relative to the mixture quality obtained, heating decoction 2 hours, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, adds relative to the rubber of 1 times of described Chinese medicine each raw medicinal material quality sum, the Colophonium of 1 times, mixing, make coating, carry out painting cream, cut off, lid lining, section, namely obtains described paster agent.
Toxicity test
1. acute percutaneous test: SD rat 20, male and female half and half, body weight 90g ~ 180g, the gel embodiment of the present invention 1 obtained 1 percutaneous smear 5000mg/kg body weight dose, observe 15 days, do not find obvious poisoning symptom, without dead, animal gross anatomy no abnormality seen, judges that medicine of the present invention is to the nontoxic level in the true border of rat acute percutaneous toxicity.
2. Skin Irritation Test: male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, the gel 2 embodiment 2 obtained directly to spread upon on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, after removing tested material, 1h, 24h, 48h and 72h observe the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judges that medicine of the present invention is to animal skin nonirritant.
3. hypersensitive test: get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The paster agent of getting the embodiment of the present invention 3 is affixed on unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, this lotion of the same area rinsed, after at once observe, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.It can thus be appreciated that medicine of the present invention can not be irritated.
Clinical trial
Treatment target: select certain hospital's traumatic surface infected patient 200 example.Man patient 148 example, female patient 152 example.Be divided into four groups at random, embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group.Age, the course of disease, wound area are without very large gap.
Diagnostic criteria
1, the wound experience such as operation, burn or skin injury are had;
2, wound surface is had.
Therapeutic Method:
Embodiment 1 group: this is organized 50 people and uses the gel 1 of embodiments of the invention 1 to treat.Every day 2 times, each 10g that uses smears wound face, and within 5 days, be a course for the treatment of, 2 courses for the treatment of are carried out in treatment.
Embodiment 2 groups: this is organized 50 people and uses the gel 2 of embodiments of the invention 2 to treat.Every day 2 times, each 10g that uses smears wound face, and within 5 days, be a course for the treatment of, 2 courses for the treatment of are carried out in treatment.
Embodiment 3 groups: this is organized 50 people and uses the paster agent of embodiments of the invention 3 to treat.Every day 2 times, paster agent (every agent 10g crude drug) is affixed on traumatic infection, 5 days be a course for the treatment of at every turn, and 2 courses for the treatment of are carried out in treatment.
Matched group: this is organized 50 people and uses erythromycin ointment to treat.Be applied to affected part, 2 times on the one.Within 5 days, be a course for the treatment of, 2 courses for the treatment of are carried out in treatment.
Criterion of therapeutical effect
Healing: traumatic infection disappears, and wound surface cambium bears; Effective: traumatic infection disappears substantially, wound surface cambium starts to bear; Invalid: traumatic infection without improvement or more serious.
Therapeutic outcome
Table 1 is the treatment situation contrast of each group
| Group | Healing | Effectively | Invalid |
| Embodiment 1 group | 49（98%） | 1（2%） | 0（0%） |
| Embodiment 2 groups | 49（98%） | 1（2%） | 0（0%） |
| Embodiment 3 groups | 50（100%） | 0（0%） | 0（0%） |
| Matched group | 40（80%） | 5（10%） | 5（10%） |
As can be seen from Table 1, the treatment situation of three treatment groups is better than matched group.It can thus be appreciated that medicine of the present invention, treatment traumatic surface infects, good effect, determined curative effect.
The side effect that table 2 is each group occurs that situation contrasts
| Group | There is number in side effect | Side effect occurrence rate |
| Embodiment 1 group | 0 | 0 |
| Embodiment 2 groups | 0 | 0 |
| Embodiment 3 groups | 0 | 0 |
| Matched group | 8 | 16% |
As can be seen from Table 2, in the therapeutic process of four treatment groups, there is not any side effect, it can thus be appreciated that medicine of the present invention, treatment traumatic infection, safety has no side effect.
In sum, medicine of the present invention, treatment traumatic infection, good effect, determined curative effect, and have no side effect, safe and effective.
Model case: Yucheng institute of traditional Chinese medicine patient in 2005,34 years old, male, peasant, during because of dry farm work, cut upper arm because of carelessness, rear discovery local temperature increase, rubescent, swelling medical, the dark 0.5CM of the long 6CM of wound.Be diagnosed as traumatic infection, use the gel 1 of embodiments of the invention 1 to treat.Every day 2 times, each 10g that uses smears wound face, and within 5 days, be a course for the treatment of, 2 courses for the treatment of are carried out in treatment.Through treatment, disease disappears, and cures completely, and without any discomfort in therapeutic process.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. the antibacterial gel for the treatment of traumatic surface and infecting, it is characterized in that, described gel is obtained by following raw medicinal material: Rhizoma Cimicifugae, Radix Bupleuri, Lasiosphaera Seu Calvatia, the Radix Astragali, Rhizoma Bistortae, Pseudobulbus Bletillae (Rhizoma Bletillae), Olibanum, Myrrha, Sanguis Draxonis, catechu, Rhizoma Sparganii, Rhizoma Curcumae, Cortex Cinnamomi, Semen Sinapis Albae, Rhizoma Dioscoreae, Mel, the Rhizoma Atractylodis Macrocephalae, Herba Acalyphae, Herba Pteridis Multifidae, Ilex viridis Champ., Fel Carassius auratus, Radix Apludate Muticae, Semen abelmoschi manihot, Radix aconiti szechenyiani, Herba Passiflorae Wilsonii, Radix Ranunculi Ternati, Herba Galii Bungei and turning seven.
2. gel according to claim 1, it is characterized in that, described gel is obtained by the raw medicinal material of following weight portion: Rhizoma Cimicifugae 10-20 weight portion, Radix Bupleuri 8-12 weight portion, Lasiosphaera Seu Calvatia 3-5 weight portion, Radix Astragali 15-20 weight portion, Rhizoma Bistortae 12-25 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-14 weight portion, Olibanum 8-12 weight portion, Myrrha 4-8 weight portion, Sanguis Draxonis 3-7 weight portion, catechu 5-9 weight portion, Rhizoma Sparganii 10-14 weight portion, Rhizoma Curcumae 3-6 weight portion, Cortex Cinnamomi 10-20 weight portion, Semen Sinapis Albae 15-20 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Mel 3-7 weight portion, Rhizoma Atractylodis Macrocephalae 10-20 weight portion, Herba Acalyphae 4-9 weight portion, Herba Pteridis Multifidae 10-20 weight portion, Ilex viridis Champ. 15-25 weight portion, Fel Carassius auratus 4-8 weight portion, Radix Apludate Muticae 10-20 weight portion, Semen abelmoschi manihot 14-22 weight portion, Radix aconiti szechenyiani 2-4 weight portion, Herba Passiflorae Wilsonii 10-20 weight portion, Radix Ranunculi Ternati 10-20 weight portion, Herba Galii Bungei 15-20 weight portion and turning seven 2-5 weight portion.
3. gel according to claim 1 and 2, it is characterized in that, described gel is obtained by the raw medicinal material of following weight portion: Rhizoma Cimicifugae 15-20 weight portion, Radix Bupleuri 8-12 weight portion, Lasiosphaera Seu Calvatia 3-5 weight portion, Radix Astragali 15-20 weight portion, Rhizoma Bistortae 12-20 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-14 weight portion, Olibanum 8-12 weight portion, Myrrha 4-8 weight portion, Sanguis Draxonis 3-7 weight portion, catechu 5-9 weight portion, Rhizoma Sparganii 10-14 weight portion, Rhizoma Curcumae 3-6 weight portion, Cortex Cinnamomi 15-20 weight portion, Semen Sinapis Albae 15-20 weight portion, Rhizoma Dioscoreae 15-20 weight portion, Mel 3-7 weight portion, Rhizoma Atractylodis Macrocephalae 10-15 weight portion, Herba Acalyphae 4-9 weight portion, Herba Pteridis Multifidae 15-20 weight portion, Ilex viridis Champ. 15-20 weight portion, Fel Carassius auratus 4-8 weight portion, Radix Apludate Muticae 15-20 weight portion, Semen abelmoschi manihot 14-22 weight portion, Radix aconiti szechenyiani 2-4 weight portion, Herba Passiflorae Wilsonii 15-20 weight portion, Radix Ranunculi Ternati 10-15 weight portion, Herba Galii Bungei 15-20 weight portion and turning seven 2-5 weight portion.
4. the gel according to any one of claims 1 to 3, it is characterized in that, described gel is obtained by the raw medicinal material of following weight portion: Rhizoma Cimicifugae 16 weight portion, Radix Bupleuri 9 weight portion, Lasiosphaera Seu Calvatia 4 weight portion, the Radix Astragali 18 weight portion, Rhizoma Bistortae 22 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 weight portion, Olibanum 10 weight portion, Myrrha 5 weight portion, Sanguis Draxonis 6 weight portion, catechu 6 weight portion, Rhizoma Sparganii 12 weight portion, Rhizoma Curcumae 5 weight portion, Cortex Cinnamomi 12 weight portion, Semen Sinapis Albae 16 weight portion, Rhizoma Dioscoreae 18 weight portion, Mel 4 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Herba Acalyphae 5 weight portion, Herba Pteridis Multifidae 12 weight portion, Ilex viridis Champ. 18 weight portion, Fel Carassius auratus 5 weight portion, Radix Apludate Muticae 16 weight portion, Semen abelmoschi manihot 16 weight portion, Radix aconiti szechenyiani 3 weight portion, Herba Passiflorae Wilsonii 16 weight portion, Radix Ranunculi Ternati 16 weight portion, Herba Galii Bungei 17 weight portion and turning 73 weight portion.
5. the gel according to claim 1 or 3, it is characterized in that, described gel is obtained by the raw medicinal material of following weight portion: Rhizoma Cimicifugae 16 weight portion, Radix Bupleuri 9 weight portion, Lasiosphaera Seu Calvatia 4 weight portion, the Radix Astragali 16 weight portion, Rhizoma Bistortae 15 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 weight portion, Olibanum 10 weight portion, Myrrha 6 weight portion, Sanguis Draxonis 5 weight portion, catechu 6 weight portion, Rhizoma Sparganii 12 weight portion, Rhizoma Curcumae 5 weight portion, Cortex Cinnamomi 16 weight portion, Semen Sinapis Albae 16 weight portion, Rhizoma Dioscoreae 16 weight portion, Mel 5 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Herba Acalyphae 5 weight portion, Herba Pteridis Multifidae 18 weight portion, Ilex viridis Champ. 15 weight portion, Fel Carassius auratus 5 weight portion, Radix Apludate Muticae 16 weight portion, Semen abelmoschi manihot 16 weight portion, Radix aconiti szechenyiani 3 weight portion, Herba Passiflorae Wilsonii 16 weight portion, Radix Ranunculi Ternati 12 weight portion, Herba Galii Bungei 16 weight portion and turning 73 weight portion.
6. the gel according to any one of claim 1 to 5, is characterized in that, its preparation method comprises the following steps:
The first step: get described raw medicinal material and add water extraction 1-2 time, extracting solution is condensed into extractum shape, be component 1, medicinal residues are for subsequent use;
Second step: the medicinal residues first step obtained add 82-90% soak with ethanol 1.0-1.5 hour, extract twice, each 1 hour, merge extractive liquid, filter, concentrated, 135-170 order filter, 6200-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5300-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 96 DEG C 1.30 extractum, heating and refluxing extraction 2 times, each 45-50 minute, extracts active ingredient, 2 extracting solution are merged and is settled into extractum shape, as component 2;
3rd step: component 1 and component 2 are mixed, adds mixing by the sodium carboxymethyl cellulose of mixture 0.1-0.5 times amount and the water of 1-2 times amount, under the high-speed stirred of agitator, concentrates and obtains gel.
7. a preparation method for the gel according to any one of claim 1 to 5, is characterized in that, its preparation method comprises:
The first step: get described raw medicinal material and add water extraction 1-2 time, extracting solution is condensed into extractum shape, be component 1, medicinal residues are for subsequent use;
Second step: the medicinal residues first step obtained add 82-90% soak with ethanol 1.0-1.5 hour, extract twice, each 1 hour, merge extractive liquid, filter, concentrated, 135-170 order filter, 6200-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5300-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 96 DEG C 1.30 extractum, heating and refluxing extraction 2 times, each 45-50 minute, extracts active ingredient, 2 extracting solution are merged and is settled into extractum shape, as component 2;
3rd step: component 1 and component 2 are mixed, adds mixing by the sodium carboxymethyl cellulose of mixture 0.1-0.5 times amount and the water of 1-2 times amount, under the high-speed stirred of agitator, concentrates and obtains gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510425600.7A CN104971315A (en) | 2015-07-20 | 2015-07-20 | Antibacterial gel for treating injury wound infection and preparation method of antibacterial gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510425600.7A CN104971315A (en) | 2015-07-20 | 2015-07-20 | Antibacterial gel for treating injury wound infection and preparation method of antibacterial gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104971315A true CN104971315A (en) | 2015-10-14 |
Family
ID=54268635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510425600.7A Withdrawn CN104971315A (en) | 2015-07-20 | 2015-07-20 | Antibacterial gel for treating injury wound infection and preparation method of antibacterial gel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104971315A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617273A (en) * | 2016-02-19 | 2016-06-01 | 季新玲 | Pharmaceutic preparation for promoting wound healing and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131018A (en) * | 1995-03-15 | 1996-09-18 | 吕建军 | Anti-inflammation debridement drug composition |
| CN101264196A (en) * | 2008-04-30 | 2008-09-17 | 吴振林 | Externally-applied medicinal composition for treating surgical wound and preparation of ointment thereof |
-
2015
- 2015-07-20 CN CN201510425600.7A patent/CN104971315A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131018A (en) * | 1995-03-15 | 1996-09-18 | 吕建军 | Anti-inflammation debridement drug composition |
| CN101264196A (en) * | 2008-04-30 | 2008-09-17 | 吴振林 | Externally-applied medicinal composition for treating surgical wound and preparation of ointment thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617273A (en) * | 2016-02-19 | 2016-06-01 | 季新玲 | Pharmaceutic preparation for promoting wound healing and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102091203B (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| CN102847063B (en) | Traditional Chinese medicinal composition for treating qi and blood deficiency blood stasis type diabetic feet, and its preparation method | |
| CN102772712B (en) | Traditional Chinese medicine composition for treating heat-toxicity, flourishing and blood stasis type diabetic foot | |
| CN102861287A (en) | Chinese medicinal composition for treating damp-heat invasion blood stasis diabetic foot and preparation method thereof | |
| CN104906465A (en) | Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof | |
| CN103933405A (en) | Pharmaceutical composition for treating qi-blood deficiency burn, and preparation method thereof | |
| CN102178781B (en) | Chinese medicine composition for treating scrotum eczema and preparation method thereof | |
| CN103933393A (en) | Traditional Chinese medicine for treating suppurative arthritis and preparation method thereof | |
| CN105456644A (en) | External lotion for perineal laceration postoperative nursing and preparation method thereof | |
| CN105362839A (en) | Traditional Chinese medicine composition for treating gynecologic inflammation | |
| CN104645122A (en) | Medicine for treating toxic heat immersion type bedsore and preparation method thereof | |
| CN104147516A (en) | Traditional Chinese medicine formula for treating osteomyelitis | |
| CN103977367A (en) | Traditional Chinese medicament for treating qi-stagnation blood-aggregation type bedsore and preparation method thereof | |
| CN106620402A (en) | Traditional Chinese medicine composition taken after operation of liver cancer and preparation method thereof | |
| CN107412557A (en) | A kind of Chinese medicine composition and preparation method for being used to treat kidney deficiency and soreness and weakness of waist and knees | |
| CN104971315A (en) | Antibacterial gel for treating injury wound infection and preparation method of antibacterial gel | |
| CN104623304A (en) | Lotion for treating chronic skin ulcer caused by damp-heat and toxicity accumulation and preparation method of lotion | |
| CN104758754A (en) | Medicine for treating kidney qi deficiency benign prostate hyperplasia and preparation method thereof | |
| CN104225256A (en) | Chinese medicine for treating fire toxin invagination type burning and preparation method | |
| CN105362944A (en) | Traditional Chinese medicine ointment for treating orthopedics sprain and contusion | |
| CN105456933A (en) | Traditional Chinese medicine capable of activating blood to remove stasis and clearing and activating channels and collaterals and preparation method of traditional Chinese medicine | |
| CN105311485A (en) | Preparation method of oral liquid for treating and treating toxic and side effect reactions of radiotherapy and chemotherapy | |
| CN104815246A (en) | Medicine used for nursing and treating burn due to invasion of interior by toxic fire and preparation method of medicine | |
| CN103566117A (en) | Ointment for external use for bone-injury hemorrhagic disease and preparation method thereof | |
| CN105168354A (en) | Traditional Chinese medicine composition for promoting postoperative wound healing and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20151014 |