CN105456644A

CN105456644A - External lotion for perineal laceration postoperative nursing and preparation method thereof

Info

Publication number: CN105456644A
Application number: CN201511002407.9A
Authority: CN
Inventors: 焦福艳
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-26
Filing date: 2015-12-26
Publication date: 2016-04-06

Abstract

The invention discloses an external lotion for perineal laceration postoperative nursing and a preparation method thereof. The external lotion mainly comprises the following raw materials: Yunnan rhubarb, root of soulie barberry, root of Chinese peashrub, root of watter milkwort, leaf of Yunnan machilus, lycogala epidendrum, root of fragile blueberry, saxifrage, rhizome of fourleaf paris, artemisia sieversiana, Japanese ampelopsis, herb of christina loosestrife, root of dunn antictrema, Asiatic pennywort herb extract and giant knotweed rhizome extract. A reasonable medicine proportion scheme and an extraction method are adopted, the prepared lotion has the effects of diminishing inflammation to relieve pain, promoting tissue regeneration and expelling pus, clearing away heat and toxic materials, and nourishing yin and eliminating dampness, has a very good curative effect on mild perineal laceration and perineal laceration postoperative complications, does not have any toxic or side effects, and is safe and reliable.

Description

A kind of external-use lotion for perineal laceration postoperative care and preparation method thereof

Technical field

The present invention relates to medicaments nursing field, specifically relate to a kind of external-use lotion for perineal laceration postoperative care and preparation method thereof.

Background technology

Perineal laceration is much in puerpera produces, due to the multiformity of modern diet structure, puerpera's overnutrition, fetus is excessive, difficult labour, comprises individual physique, each grade Hospital medical level and medical personnel's level difference, birth process such as to deal with improperly at the problem, makes perineal laceration phenomenon have a strong impact on the orthobiosis in puerpera's puerperal.Perineal laceration is generally divided into three degree, I degree, II degree of perineal laceration symptom are lighter, hemorrhage less, after correct stitching, can heal well greatly, III Degree perineum laceration, also known as the complete laceration of perineum, comprises the laceration of vaginal orifice laceration, perineal laceration and anal sphincter, severe patient breaks and is extensible to rectal wall, causes fecal incontinence.Perineal laceration to put prevention first, should carry out parturient prenatal examination, comprises a series of situations of fetus size, the fetus position etc., notes protecting perineum when delivering a child in addition, makes the laceration of perineum drop to minimum degree.When generation III degree of perineal laceration, should adopt repair, generally after Placenta Hominis is given birth to, patient profiles carries out under allowing immediately, also can postpone and carrying out for 12-24 hour, should note avoiding infecting in art, postoperatively carries out nursing, avoids causing complication.The complication of perineal laceration appears at three to seven days puerperal usually, mostly be perineal position, sacrococcygeal region scytitis and pressure ulcer, due to the stimulation of stool, perineal skin is made often to be in erosion state that is moist and metabolite, easy generation red swelling of the skin, fester, skin ulceration infect can deeply and muscle layer or ulceration extend to scrotum, labia, groin place, thus pollution urethral orifice, vaginal orifice causes retrograde infection, not only increase the weight of the misery of patient, bring difficulty to clinical nursing activity simultaneously, existing clinical nursing activity many employings medicine demibain and antibiotic therapy, but due to the particularity of puerpera, antibiotic use can bring impact to puerpera's health, by the transmission of milk, thus affect the growth promoter of baby.The traditional Chinese medical science has the advantage of oneself uniqueness in treatment particularity human diseases with its distinctive safety, due to the physical and mental health of puerpera and baby closely bound up, so development is a kind of safe and effective, the medicine for perineal laceration postoperative care had no side effect is exactly the problem to be solved in the present invention.

Summary of the invention

The technical problem that the present invention solves is to provide a kind of external-use lotion for perineal laceration postoperative care and preparation method thereof.

For solving the problems of the technologies described above, the technical solution adopted in the present invention is:

For an external-use lotion for perineal laceration postoperative care, be mainly made up of the raw material of following weight portion: husky seven 56-78 parts, Radix Berberidis soulieanae 53-75 part, shortleaf peashrub 50-70 part, Radix Polygalae Wattersii 46-68 part, Folium Machili yunnanensis 41-63 part, sebaceous cyst bacterium 34-59 part, Folium Vaccinii Fragilis 30-52 part, tiger ear 27-49 part, Rhizoma Paridis tetraphyllae 24-41 part, Artemisia sieversiana Willd. 20-34 part, Bletilla striata (Thunb.ex A.Murray)Rchb.f. 15-32 part, Lysimachia christinae Hance 11-27 part, Radix Antiotrematis dunniani 10-22 part, Herba Centellae extract 4-9 part, Rhizoma Polygoni Cuspidati extract 2-8 part.

Further, for an external-use lotion for perineal laceration postoperative care, be mainly made up of the raw material of following weight portion: 7 67 parts, sand, Radix Berberidis soulieanae 64 parts, shortleaf peashrub 60 parts, Radix Polygalae Wattersii 57 parts, Folium Machili yunnanensis 52 parts, sebaceous cyst bacterium 46.5 parts, Folium Vaccinii Fragilis 41 parts, 38 parts, tiger ear, Rhizoma Paridis tetraphyllae 32.5 parts, Artemisia sieversiana Willd. 27 parts, Bletilla striata (Thunb.ex A.Murray)Rchb.f. 23.5 parts, Lysimachia christinae Hance 19 parts, Radix Antiotrematis dunniani 16 parts, Herba Centellae extract 6.5 parts, Rhizoma Polygoni Cuspidati extract 5 parts.

Further, the extracting method of described Herba Centellae extract is: get the Herba Centellae of drying, be placed in dehydrator to dry, arranging bake out temperature is 60-68 DEG C, drying time is 8-10min, again it is ground into 40-60 object coarse powder with disintegrating machine, coarse powder is added in Chinese medicine flash extracter, adding 15 times amount mass concentrations is the alcoholic solution of 82%, extract three times, each 2min, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.012-0.018 μm, re-use high performance liquid chromatography and carry out purification, the form of sample introduction is adopted repeatedly to improve purity, the liquid pressure-reducing collecting asiaticoside place is concentrated into crystal and separates out, pulverize with crystal pulverizer after dry, cross 170 mesh sieves, obtain asiaticoside.Asiaticoside has antibacterial, antioxidation, removing toxic substances and promoting subsidence of swelling, promotes effect of wound healing, in the treatment of dermatosis, has good effect.

Further, the extracting method of described Rhizoma Polygoni Cuspidati extract is: the rhizome getting Rhizoma Polygoni Cuspidati drying, 30-40 object coarse powder is ground into pulverizer after section, put into enzymatic vessel, add the pure water of 6 times amount, add the cellulase of 0.25-0.43 part composition by weight again, arranging hydrolysis temperature is 28-40 DEG C, enzymolysis time is 3-5 days, then rapid temperature increases to 85 DEG C enzyme denaturing is lived and is incubated lixiviate 40min, the mass concentration adding 7-9 times amount in gained enzymolysis solution is the alcoholic solution of 63%, heating and refluxing extraction twice, each 2.5h, merge extractive liquid, use macroporous resin column separating-purifying, gained eluent is evaporated to moisture lower than 3%, be ground into fine powder again, cross 150 mesh sieves, obtain Rhizoma Polygoni Cuspidati extract.Rhizoma Polygoni Cuspidati extract has clearing heat and expelling damp, antioxidation, antibacterial, pain relieving, has good effect for prevention of postoperative wound infection.

For a preparation method for the external-use lotion of perineal laceration postoperative care, comprise the following steps:

(1) Herba Centellae of drying is got, be placed in dehydrator to dry, arranging bake out temperature is 60-68 DEG C, drying time is 8-10min, again it is ground into 40-60 object coarse powder with disintegrating machine, coarse powder is added in Chinese medicine flash extracter, adding 15 times amount mass concentrations is the alcoholic solution of 82%, extract three times, each 2min, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.012-0.018 μm, re-use high performance liquid chromatography and carry out purification, the form of sample introduction is adopted repeatedly to improve purity, the liquid pressure-reducing collecting asiaticoside place is concentrated into crystal and separates out, pulverize with crystal pulverizer after dry, cross 170 mesh sieves, obtain asiaticoside, for subsequent use, asiaticoside has antibacterial, antioxidation, removing toxic substances and promoting subsidence of swelling, promote effect of wound healing, good effect is had in the treatment of dermatosis,

(2) rhizome of Rhizoma Polygoni Cuspidati drying is got, 30-40 object coarse powder is ground into pulverizer after section, put into enzymatic vessel, add the pure water of 6 times amount, add the cellulase of 0.25-0.43 part composition by weight again, arranging hydrolysis temperature is 28-40 DEG C, enzymolysis time is 3-5 days, then rapid temperature increases to 85 DEG C enzyme denaturing is lived and is incubated lixiviate 40min, the mass concentration adding 7-9 times amount in gained enzymolysis solution is the alcoholic solution of 63%, heating and refluxing extraction twice, each 2.5h, merge extractive liquid, use macroporous resin column separating-purifying, gained eluent is evaporated to moisture lower than 3%, be ground into fine powder again, cross 150 mesh sieves, obtain Rhizoma Polygoni Cuspidati extract, for subsequent use, Rhizoma Polygoni Cuspidati extract has clearing heat and expelling damp, antioxidation, antibacterial, pain relieving, good effect is had for prevention of postoperative wound infection,

(3) husky seven are taken according to described weight proportion, Radix Berberidis soulieanae, shortleaf peashrub, Folium Vaccinii Fragilis, Rhizoma Paridis tetraphyllae, Bletilla striata (Thunb.ex A.Murray)Rchb.f., Lysimachia christinae Hance dry product, 20-40 object coarse powder is ground into after section, mix homogeneously, the mass concentration being placed in 3 times amount be 60% alcoholic solution soak 7h, the mass concentration adding 7-11 times amount is again the alcoholic solution of 76%, heating and refluxing extraction 3.5h, filter, the mass concentration adding 6-8 times amount again in filtering residue is the alcoholic solution of 73%, reflux, extract, 2.3h, microwave radiation exaraction is adopted while alcohol reflux, arranging microwave frequency is 370-450MHz, filter, merge twice gained filtrate, decompression recycling ethanol, concentrate and obtain the thick paste that proportion is d=1.13-1.27, for subsequent use, adopt microwave radiation exaraction that extracts active ingredients ground can be made more thorough while alcohol reflux,

(4) Radix Polygalae Wattersii is taken according to described weight proportion, Folium Machili yunnanensis, sebaceous cyst bacterium, tiger ear, Artemisia sieversiana Willd., Radix Antiotrematis dunniani, remove impurity cleans up, be placed in dehydrator to dry, arranging bake out temperature is 59-71 DEG C, drying time is 5-11min, again it is ground into coarse powder with disintegrating machine, cross 40-50 mesh sieve, then use microwave at 115-125 DEG C of sterilizing 3min, be that the alcoholic solution of 62%-70% mixes by the solid-liquid ratio of 1:9 by coarse powder and mass concentration, obtain mixed liquor to add in ultrasonic extractor and carry out supersound extraction 1-1.4h, the extracting solution centrifuge obtained is with the centrifugal 15min of the rotating speed of 200r/min, get supernatant, concentrating under reduced pressure reclaims ethanol, sterilizing, obtain the thick paste that proportion is d=1.08-1.23, for subsequent use,

(5) thick paste mixing step (3) and (4) obtained, add the pure water of 7-9 times amount, component meter by weight, add PEG400 4-6 part that mass concentration is 15% again, chlorhexidine acetate 3-5 part, glycerol 2-4 part, press the rotating speed stirring 30min of 450-510r/min with blender after mixing, be placed in homogenizing process 30min in homogenizer again, filter, the obtained Herba Centellae extract in step (1) and (2) and Rhizoma Polygoni Cuspidati extract is added again by described composition by weight, mixing and stirring, sterilizing, packaging is sealed up for safekeeping, obtain described external-use lotion, Polyethylene Glycol series of products are conventional pharmaceutic adjuvants, PEG400 can make emulsifying agent and the cosolvent of lotion, medicine can be made to mix better, improve drug effect, glycerol has antibacterial effect, also can play moisturizing to skin and extend the effect of drug effect, chlorhexidine acetate is the antiseptic of external-use lotion, also has antibacterial effect simultaneously.

The pharmacologically active of medical material selected by the present invention is:

Husky seven: [nature and flavor] are bitter, cool.[function cures mainly] heat clearing and inflammation relieving, hemostasia and promoting granulation; Cure mainly cough due to lung-heat, have sore throat, stool hematochezia, traumatic hemorrhage, fracture, osteopatia sprain, rheumatic arthralgia etc.

Radix Berberidis soulieanae: [nature and flavor] are bitter, cold.[function cures mainly] heat clearing and inflammation relieving, reducing swelling and alleviating pain; Treating the liver is scorching, aphtha of the mouth and tongue, and urine leaching pain, scalds.

Shortleaf peashrub: [nature and flavor] are pungent, bitter, cold.[function cures mainly] heat clearing away is loose swollen, granulation promoting pain relieving; Cure mainly carbuncle, furuncle, swell and ache.

Radix Polygalae Wattersii: [nature and flavor] are sweet, bitter is flat.[function cures mainly] heat clearing and inflammation relieving, hemostasia and promoting granulation; Chronic tracheitis, fracture is controlled in external, traumatic hemorrhage, sprains pain.

Folium Machili yunnanensis: [nature and flavor] are bitter, puckery, cool.[function cures mainly] heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Main mumps, sore, burn due to hot liquid or fire, rheumatic arthralgia, injury and bone fracture.

Sebaceous cyst bacterium: [nature and flavor] are light; Be slightly cold.[function cures mainly] heat clearing and inflammation relieving.

Folium Vaccinii Fragilis: [nature and flavor] are puckery, cold.[function cures mainly] relaxing muscles and tendons to promote blood circulation, anti-inflammatory analgetic; For rheumatic arthritis, traumatic injury, parotitis, acute conjunctivitis, dysentery, stomachache.

Tiger ear: [function cures mainly] replenishing QI and blood, wind-damp dispelling, the meridian dredging, detumescence poison; Main gas loses blood deficiency, rheumatic arthralgia, and contracture is numb, and knife injury is hemorrhage, aphtha.

Rhizoma Paridis tetraphyllae: [nature and flavor] are bitter, pungent, temperature.[function cures mainly] expelling cold and dampness, removing obstruction in the collateral to relieve pain, hemostasia and promoting granulation; Main chronic arthralgia caused by cold-damp, waist cold type of pain, traumatic hemorrhage.

Artemisia sieversiana Willd.: [nature and flavor] are bitter, cool.[function cures mainly] anti-inflammatory analgetic.

Bletilla striata (Thunb.ex A.Murray)Rchb.f.: [nature and flavor] are bitter, sweet, puckery, cold.[function cures mainly] astringing to arrest bleeding, detumescence and promoting granulation; Main spitting of blood, spit blood, epistaxis, has blood in stool, traumatic hemorrhage, carbuncle pyogenic infections from tumour or sore, scalds and burns, rhagadia manus et pedis, anal fissure.

Lysimachia christinae Hance: [nature and flavor] are light, cool in nature.[function cures mainly] dissipating blood stasis for subsidence of swelling, granulation promoting pain relieving; Main traumatic injury, fracture, wound.

Radix Antiotrematis dunniani: [nature and flavor] are bitter, micro-sweet, are slightly cold.[function cures mainly] replenishing YIN and removing heat, eliminating damp, detoxifying, dissipating blood stasis for subsidence of swelling; Main empty tumor heating, urine leaching is puckery, carbuncle sore tumefacting virus, acute gangrenous stomatitis, traumatic injury.

Herba Centellae extract: have antibacterial, antioxidation, clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling, has good effect in the treatment of dermatosis.

Rhizoma Polygoni Cuspidati extract: have clearing heat and expelling damp, antioxidation, antibacterial, pain relieving, has good effect for prevention of postoperative wound infection.

Compared with prior art, the invention has the beneficial effects as follows: for the postoperative postoperative infection that may occur of perineal laceration and complication, selected multiple Chinese herbal medicine and Chinese herbal medicine extract, there is anti-inflammatory analgetic, granulation promoting evacuation of pus, heat-clearing and toxic substances removing, effect of yin nourishing dehumidifying, good curative effect is had to slight perineal laceration and perineal laceration post-operative complication, without any side effects, extend to the clinical treatment of perineal laceration.

Detailed description of the invention

Below in conjunction with concrete embodiment, further restriction is done to technical scheme of the present invention, but claimed scope is not only confined to done description.

Embodiment 1:

For an external-use lotion for perineal laceration postoperative care, component meter is made up of following raw material by weight: 7 56 parts, sand, Radix Berberidis soulieanae 53 parts, shortleaf peashrub 50 parts, Radix Polygalae Wattersii 46 parts, Folium Machili yunnanensis 41 parts, sebaceous cyst bacterium 34 parts, Folium Vaccinii Fragilis 30 parts, 27 parts, tiger ear, Rhizoma Paridis tetraphyllae 24 parts, Artemisia sieversiana Willd. 20 parts, Bletilla striata (Thunb.ex A.Murray)Rchb.f. 15 parts, Lysimachia christinae Hance 11 parts, Radix Antiotrematis dunniani 10 parts, Herba Centellae extract 4 parts, Rhizoma Polygoni Cuspidati extract 2 parts.

(1) Herba Centellae of drying is got, be placed in dehydrator to dry, arranging bake out temperature is 60 DEG C, drying time is 8min, again it is ground into 40 object coarse powder with disintegrating machine, coarse powder is added in Chinese medicine flash extracter, adding 15 times amount mass concentrations is the alcoholic solution of 82%, extract three times, each 2min, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.012 μm, re-use high performance liquid chromatography and carry out purification, the form of sample introduction is adopted repeatedly to improve purity, the liquid pressure-reducing collecting asiaticoside place is concentrated into crystal and separates out, pulverize with crystal pulverizer after dry, cross 170 mesh sieves, obtain asiaticoside, for subsequent use, asiaticoside has antibacterial, antioxidation, removing toxic substances and promoting subsidence of swelling, promote effect of wound healing, good effect is had in the treatment of dermatosis,

(2) rhizome of Rhizoma Polygoni Cuspidati drying is got, 30 object coarse powder are ground into pulverizer after section, put into enzymatic vessel, add the pure water of 6 times amount, add the cellulase of 0.25 part of composition by weight again, arranging hydrolysis temperature is 28 DEG C, enzymolysis time is 3 days, then rapid temperature increases to 85 DEG C enzyme denaturing is lived and is incubated lixiviate 40min, the mass concentration adding 7 times amount in gained enzymolysis solution is the alcoholic solution of 63%, heating and refluxing extraction twice, each 2.5h, merge extractive liquid, use macroporous resin column separating-purifying, gained eluent is evaporated to moisture lower than 3%, be ground into fine powder again, cross 150 mesh sieves, obtain Rhizoma Polygoni Cuspidati extract, for subsequent use, Rhizoma Polygoni Cuspidati extract has clearing heat and expelling damp, antioxidation, antibacterial, pain relieving, good effect is had for prevention of postoperative wound infection,

(3) husky seven are taken according to described weight proportion, Radix Berberidis soulieanae, shortleaf peashrub, Folium Vaccinii Fragilis, Rhizoma Paridis tetraphyllae, Bletilla striata (Thunb.ex A.Murray)Rchb.f., Lysimachia christinae Hance dry product, 20 object coarse powder are ground into after section, mix homogeneously, the mass concentration being placed in 3 times amount be 60% alcoholic solution soak 7h, the mass concentration adding 7 times amount is again the alcoholic solution of 76%, heating and refluxing extraction 3.5h, filter, the mass concentration adding 6 times amount again in filtering residue is the alcoholic solution of 73%, reflux, extract, 2.3h, microwave radiation exaraction is adopted while alcohol reflux, arranging microwave frequency is 370MHz, filter, merge twice gained filtrate, decompression recycling ethanol, concentrate and obtain the thick paste that proportion is d=1.13, for subsequent use, adopt microwave radiation exaraction that extracts active ingredients ground can be made more thorough while alcohol reflux,

(4) Radix Polygalae Wattersii is taken according to described weight proportion, Folium Machili yunnanensis, sebaceous cyst bacterium, tiger ear, Artemisia sieversiana Willd., Radix Antiotrematis dunniani, remove impurity cleans up, be placed in dehydrator to dry, arranging bake out temperature is 59 DEG C, drying time is 5min, again it is ground into coarse powder with disintegrating machine, cross 40 mesh sieves, then use microwave at 115 DEG C of sterilizing 3min, by coarse powder and mass concentration be 62% alcoholic solution mix by the solid-liquid ratio of 1:9, obtain mixed liquor to add in ultrasonic extractor and carry out supersound extraction 1h, the extracting solution centrifuge obtained is with the centrifugal 15min of the rotating speed of 200r/min, get supernatant, concentrating under reduced pressure reclaims ethanol, sterilizing, obtain the thick paste that proportion is d=1.08, for subsequent use,

(5) thick paste mixing step (3) and (4) obtained, add the pure water of 7 times amount, component meter by weight, add the PEG400 4 parts that mass concentration is 15% again, chlorhexidine acetate 3 parts, glycerol 2 parts, press the rotating speed stirring 30min of 450r/min with blender after mixing, be placed in homogenizing process 30min in homogenizer again, filter, the obtained Herba Centellae extract in step (1) and (2) and Rhizoma Polygoni Cuspidati extract is added again by described composition by weight, mixing and stirring, sterilizing, packaging is sealed up for safekeeping, obtain described external-use lotion, Polyethylene Glycol series of products are conventional pharmaceutic adjuvants, PEG400 can make emulsifying agent and the cosolvent of lotion, medicine can be made to mix better, improve drug effect, glycerol has antibacterial effect, also can play moisturizing to skin and extend the effect of drug effect, chlorhexidine acetate is the antiseptic of external-use lotion, also has antibacterial effect simultaneously.

Embodiment 2:

For an external-use lotion for perineal laceration postoperative care, be mainly made up of the raw material of following weight portion: 7 67 parts, sand, Radix Berberidis soulieanae 64 parts, shortleaf peashrub 60 parts, Radix Polygalae Wattersii 57 parts, Folium Machili yunnanensis 52 parts, sebaceous cyst bacterium 46.5 parts, Folium Vaccinii Fragilis 41 parts, 38 parts, tiger ear, Rhizoma Paridis tetraphyllae 32.5 parts, Artemisia sieversiana Willd. 27 parts, Bletilla striata (Thunb.ex A.Murray)Rchb.f. 23.5 parts, Lysimachia christinae Hance 19 parts, Radix Antiotrematis dunniani 16 parts, Herba Centellae extract 6.5 parts, Rhizoma Polygoni Cuspidati extract 5 parts.

(1) Herba Centellae of drying is got, be placed in dehydrator to dry, arranging bake out temperature is 64 DEG C, drying time is 9min, again it is ground into 50 object coarse powder with disintegrating machine, coarse powder is added in Chinese medicine flash extracter, adding 15 times amount mass concentrations is the alcoholic solution of 82%, extract three times, each 2min, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.015 μm, re-use high performance liquid chromatography and carry out purification, the form of sample introduction is adopted repeatedly to improve purity, the liquid pressure-reducing collecting asiaticoside place is concentrated into crystal and separates out, pulverize with crystal pulverizer after dry, cross 170 mesh sieves, obtain asiaticoside, for subsequent use, asiaticoside has antibacterial, antioxidation, removing toxic substances and promoting subsidence of swelling, promote effect of wound healing, good effect is had in the treatment of dermatosis,

(2) rhizome of Rhizoma Polygoni Cuspidati drying is got, 35 object coarse powder are ground into pulverizer after section, put into enzymatic vessel, add the pure water of 6 times amount, add the cellulase of 0.34 part of composition by weight again, arranging hydrolysis temperature is 34 DEG C, enzymolysis time is 4 days, then rapid temperature increases to 85 DEG C enzyme denaturing is lived and is incubated lixiviate 40min, the mass concentration adding 8 times amount in gained enzymolysis solution is the alcoholic solution of 63%, heating and refluxing extraction twice, each 2.5h, merge extractive liquid, use macroporous resin column separating-purifying, gained eluent is evaporated to moisture lower than 3%, be ground into fine powder again, cross 150 mesh sieves, obtain Rhizoma Polygoni Cuspidati extract, for subsequent use, Rhizoma Polygoni Cuspidati extract has clearing heat and expelling damp, antioxidation, antibacterial, pain relieving, good effect is had for prevention of postoperative wound infection,

(3) husky seven are taken according to described weight proportion, Radix Berberidis soulieanae, shortleaf peashrub, Folium Vaccinii Fragilis, Rhizoma Paridis tetraphyllae, Bletilla striata (Thunb.ex A.Murray)Rchb.f., Lysimachia christinae Hance dry product, 30 object coarse powder are ground into after section, mix homogeneously, the mass concentration being placed in 3 times amount be 60% alcoholic solution soak 7h, the mass concentration adding 9 times amount is again the alcoholic solution of 76%, heating and refluxing extraction 3.5h, filter, the mass concentration adding 7 times amount again in filtering residue is the alcoholic solution of 73%, reflux, extract, 2.3h, microwave radiation exaraction is adopted while alcohol reflux, arranging microwave frequency is 410MHz, filter, merge twice gained filtrate, decompression recycling ethanol, concentrate and obtain the thick paste that proportion is d=1.20, for subsequent use, adopt microwave radiation exaraction that extracts active ingredients ground can be made more thorough while alcohol reflux,

(4) Radix Polygalae Wattersii is taken according to described weight proportion, Folium Machili yunnanensis, sebaceous cyst bacterium, tiger ear, Artemisia sieversiana Willd., Radix Antiotrematis dunniani, remove impurity cleans up, be placed in dehydrator to dry, arranging bake out temperature is 65 DEG C, drying time is 8min, again it is ground into coarse powder with disintegrating machine, cross 45 mesh sieves, then use microwave at 120 DEG C of sterilizing 3min, by coarse powder and mass concentration be 66% alcoholic solution mix by the solid-liquid ratio of 1:9, obtain mixed liquor to add in ultrasonic extractor and carry out supersound extraction 1.2h, the extracting solution centrifuge obtained is with the centrifugal 15min of the rotating speed of 200r/min, get supernatant, concentrating under reduced pressure reclaims ethanol, sterilizing, obtain the thick paste that proportion is d=1.15, for subsequent use,

(5) thick paste mixing step (3) and (4) obtained, add the pure water of 8 times amount, component meter by weight, add the PEG400 5 parts that mass concentration is 15% again, chlorhexidine acetate 4 parts, glycerol 3 parts, press the rotating speed stirring 30min of 480r/min with blender after mixing, be placed in homogenizing process 30min in homogenizer again, filter, the obtained Herba Centellae extract in step (1) and (2) and Rhizoma Polygoni Cuspidati extract is added again by described composition by weight, mixing and stirring, sterilizing, packaging is sealed up for safekeeping, obtain described external-use lotion, Polyethylene Glycol series of products are conventional pharmaceutic adjuvants, PEG400 can make emulsifying agent and the cosolvent of lotion, medicine can be made to mix better, improve drug effect, glycerol has antibacterial effect, also can play moisturizing to skin and extend the effect of drug effect, chlorhexidine acetate is the antiseptic of external-use lotion, also has antibacterial effect simultaneously.

Embodiment 3:

For an external-use lotion for perineal laceration postoperative care, component meter is made up of following raw material by weight: 7 78 parts, sand, Radix Berberidis soulieanae 75 parts, shortleaf peashrub 70 parts, Radix Polygalae Wattersii 68 parts, Folium Machili yunnanensis 63 parts, sebaceous cyst bacterium 59 parts, Folium Vaccinii Fragilis 52 parts, 49 parts, tiger ear, Rhizoma Paridis tetraphyllae 41 parts, Artemisia sieversiana Willd. 34 parts, Bletilla striata (Thunb.ex A.Murray)Rchb.f. 32 parts, Lysimachia christinae Hance 27 parts, Radix Antiotrematis dunniani 22 parts, Herba Centellae extract 9 parts, Rhizoma Polygoni Cuspidati extract 8 parts.

(1) Herba Centellae of drying is got, be placed in dehydrator to dry, arranging bake out temperature is 68 DEG C, drying time is 10min, again it is ground into 60 object coarse powder with disintegrating machine, coarse powder is added in Chinese medicine flash extracter, adding 15 times amount mass concentrations is the alcoholic solution of 82%, extract three times, each 2min, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.018 μm, re-use high performance liquid chromatography and carry out purification, the form of sample introduction is adopted repeatedly to improve purity, the liquid pressure-reducing collecting asiaticoside place is concentrated into crystal and separates out, pulverize with crystal pulverizer after dry, cross 170 mesh sieves, obtain asiaticoside, for subsequent use, asiaticoside has antibacterial, antioxidation, removing toxic substances and promoting subsidence of swelling, promote effect of wound healing, good effect is had in the treatment of dermatosis,

(2) rhizome of Rhizoma Polygoni Cuspidati drying is got, 40 object coarse powder are ground into pulverizer after section, put into enzymatic vessel, add the pure water of 6 times amount, add the cellulase of 0.43 part of composition by weight again, arranging hydrolysis temperature is 40 DEG C, enzymolysis time is 5 days, then rapid temperature increases to 85 DEG C enzyme denaturing is lived and is incubated lixiviate 40min, the mass concentration adding 9 times amount in gained enzymolysis solution is the alcoholic solution of 63%, heating and refluxing extraction twice, each 2.5h, merge extractive liquid, use macroporous resin column separating-purifying, gained eluent is evaporated to moisture lower than 3%, be ground into fine powder again, cross 150 mesh sieves, obtain Rhizoma Polygoni Cuspidati extract, for subsequent use, Rhizoma Polygoni Cuspidati extract has clearing heat and expelling damp, antioxidation, antibacterial, pain relieving, good effect is had for prevention of postoperative wound infection,

(3) husky seven are taken according to described weight proportion, Radix Berberidis soulieanae, shortleaf peashrub, Folium Vaccinii Fragilis, Rhizoma Paridis tetraphyllae, Bletilla striata (Thunb.ex A.Murray)Rchb.f., Lysimachia christinae Hance dry product, 40 object coarse powder are ground into after section, mix homogeneously, the mass concentration being placed in 3 times amount be 60% alcoholic solution soak 7h, the mass concentration adding 11 times amount is again the alcoholic solution of 76%, heating and refluxing extraction 3.5h, filter, the mass concentration adding 8 times amount again in filtering residue is the alcoholic solution of 73%, reflux, extract, 2.3h, microwave radiation exaraction is adopted while alcohol reflux, arranging microwave frequency is 450MHz, filter, merge twice gained filtrate, decompression recycling ethanol, concentrate and obtain the thick paste that proportion is d=1.27, for subsequent use, adopt microwave radiation exaraction that extracts active ingredients ground can be made more thorough while alcohol reflux,

(4) Radix Polygalae Wattersii is taken according to described weight proportion, Folium Machili yunnanensis, sebaceous cyst bacterium, tiger ear, Artemisia sieversiana Willd., Radix Antiotrematis dunniani, remove impurity cleans up, be placed in dehydrator to dry, arranging bake out temperature is 71 DEG C, drying time is 11min, again it is ground into coarse powder with disintegrating machine, cross 50 mesh sieves, then use microwave at 125 DEG C of sterilizing 3min, by coarse powder and mass concentration be 70% alcoholic solution mix by the solid-liquid ratio of 1:9, obtain mixed liquor to add in ultrasonic extractor and carry out supersound extraction 1.4h, the extracting solution centrifuge obtained is with the centrifugal 15min of the rotating speed of 200r/min, get supernatant, concentrating under reduced pressure reclaims ethanol, sterilizing, obtain the thick paste that proportion is d=1.23, for subsequent use,

(the thick paste mixing that step (3) and (4) obtain by (5), add the pure water of 7-9 times amount, component meter by weight, add the PEG400 6 parts that mass concentration is 15% again, chlorhexidine acetate 5 parts, glycerol 4 parts, press the rotating speed stirring 30min of 450-510r/min with blender after mixing, be placed in homogenizing process 30min in homogenizer again, filter, the obtained Herba Centellae extract in step (1) and (2) and Rhizoma Polygoni Cuspidati extract is added again by described composition by weight, mixing and stirring, sterilizing, packaging is sealed up for safekeeping, obtain described external-use lotion, Polyethylene Glycol series of products are conventional pharmaceutic adjuvants, PEG400 can make emulsifying agent and the cosolvent of lotion, medicine can be made to mix better, improve drug effect, glycerol has antibacterial effect, also can play moisturizing to skin and extend the effect of drug effect, chlorhexidine acetate is the antiseptic of external-use lotion, also has antibacterial effect simultaneously.

Clinical trial:

1. clinical case is selected

1.1 choice criteria: choose the clinical patient finishing perineal laceration operation, be mainly and postoperatively occur that perineal skin is red and swollen, fester, infect to cause festering and spread to labia, the places such as groin, and the symptom of some scytitiss perineum place skin being caused due to the stimulation of defecation owing to being in dampness.

1.2 select and divide into groups: inventor collects 180 routine perineal laceration postoperative patients altogether, is divided into four groups at random, often organizes 45 people, three groups for the treatment of groups, one group of matched group.

2. test method:

2.1 matched groups: by specification usage and consumption, use the common lotion for perineum postoperative care.

2.2 treatment groups: give the treatment group patient external-use lotion using the embodiment of the present invention 1, embodiment 2 and embodiment 3 to prepare respectively, every day sooner or later respectively once.6 days courses for the treatment of, be used in conjunction 3 courses for the treatment of.

3. criterion of therapeutical effect and therapeutic outcome

3.1 criterion of therapeutical effect

(1) fully recover: the transference cure occurred clinically, ulcer place skin healing, other scytitiss are also disappeared;

(2) effective: clinical symptoms is obviously improved, or transfers to slightly by severe;

(3) invalid: symptom without improvement, or has and increases the weight of trend.

3.2 treatment statistical results

Table 1-tetra-group comparitive study

Group	Case number	Recovery from illness	Effective	Invalid	Untoward reaction	Total effective rate %
							Embodiment 1 treatment group	45	30	13	2	0	95.6
Embodiment 2 treatment group	45	38	7	0	0	100
							Embodiment 3 treatment group	45	35	9	1	0	96.7
Matched group	45	19	11	15	6	66.7

4. conclusion: in clinical trial process, the patient accepting Drug therapy of the present invention finds no any untoward reaction, as seen from the data in Table 1, the total effective rate of medicine of the present invention to perineal laceration postoperative care reaches more than 95.6%, it is the safe and effective medicine of perineal laceration postoperative care, and instant effect, without any side effects, there is good clinical meaning.

5. clinical individual case:

Case 1: Zhao, female, 25 years old, for primipara, because fetus is larger, perineum side cutting is made a slip of the tongue little, in production process, practise midwifery is dealt with improperly and is caused III degree of laceration, timely stitching process, every day in puerperal uses drug irrigation perineal wound, 5 days after operation defecation, after occur that wound healing is slow, secondary infection ulcer, use a course for the treatment of of external-use lotion prepared by the embodiment of the present invention 1, wound heals gradually, ulcer level alleviates, after three courses for the treatment of, wound heals completely, ulcer disappears, and notice that diet is light, follow up a case by regular visits to after two months, stool is normal, without any sequela.

Case 2: Wang, female, 31 years old, puerpera was elderly primipara, perineal laceration when causing childbirth because puerpera's birth canal in addition of having difficult labour is narrow, puerperal processes in time, every day is with private parts nursing and apply antibiotic therapy, but still occurs redness after an action of the bowels, ulcer greatly, secondary colpitis, use a course for the treatment of of external-use lotion prepared by the embodiment of the present invention 2, redness disappears, and ulcer spot symptom alleviates, after three courses for the treatment of, colpitis disappears, and ulcerous skin heals completely, follows up a case by regular visits to after two months, stool is normal, no sequel.

Case 3: thank certain, female, 29 years old, second time childbirth, causes outmoded perineal laceration, after sewing up process, poor wound healing, with the phenomenon having incontinence when defecating rare, brings the inconvenience of the torment of health and normal life to puerpera, use a course for the treatment of of external-use lotion prepared by the embodiment of the present invention 3, wound slowly heals, and symptom is eased, use three courses for the treatment of, wound heals completely, and stool recovers normal, follow up a case by regular visits to after two months, stool is normal, has no other sequela.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.

Claims

1. for an external-use lotion for perineal laceration postoperative care, it is characterized in that component meter is made up of following raw material by weight: husky seven 56-78 parts, Radix Berberidis soulieanae 53-75 part, shortleaf peashrub 50-70 part, Radix Polygalae Wattersii 46-68 part, Folium Machili yunnanensis 41-63 part, sebaceous cyst bacterium 34-59 part, Folium Vaccinii Fragilis 30-52 part, tiger ear 27-49 part, Rhizoma Paridis tetraphyllae 24-41 part, Artemisia sieversiana Willd. 20-34 part, Bletilla striata (Thunb.ex A.Murray)Rchb.f. 15-32 part, Lysimachia christinae Hance 11-27 part, Radix Antiotrematis dunniani 10-22 part, Herba Centellae extract 4-9 part, Rhizoma Polygoni Cuspidati extract 2-8 part.

2. a kind of external-use lotion for perineal laceration postoperative care according to claim 1, is characterized in that component meter is made up of following raw material by weight: 7 67 parts, sand, Radix Berberidis soulieanae 64 parts, shortleaf peashrub 60 parts, Radix Polygalae Wattersii 57 parts, Folium Machili yunnanensis 52 parts, sebaceous cyst bacterium 46.5 parts, Folium Vaccinii Fragilis 41 parts, 38 parts, tiger ear, Rhizoma Paridis tetraphyllae 32.5 parts, Artemisia sieversiana Willd. 27 parts, Bletilla striata (Thunb.ex A.Murray)Rchb.f. 23.5 parts, Lysimachia christinae Hance 19 parts, Radix Antiotrematis dunniani 16 parts, Herba Centellae extract 6.5 parts, Rhizoma Polygoni Cuspidati extract 5 parts.

3. a kind of external-use lotion for perineal laceration postoperative care according to claim 1 or 2 any one, it is characterized in that, described Herba Centellae extract is asiaticoside, its extracting method is: get the Herba Centellae of drying, be placed in dehydrator to dry, arranging bake out temperature is 60-68 DEG C, drying time is 8-10min, again it is ground into 40-60 object coarse powder with disintegrating machine, coarse powder is added in Chinese medicine flash extracter, adding 15 times amount mass concentrations is the alcoholic solution of 82%, extract three times, each 2min, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.012-0.018 μm, re-use high performance liquid chromatography and carry out purification, the form of sample introduction is adopted repeatedly to improve purity, the liquid pressure-reducing collecting asiaticoside place is concentrated into crystal and separates out, pulverize with crystal pulverizer after dry, cross 170 mesh sieves, obtain asiaticoside.

4. a kind of external-use lotion for perineal laceration postoperative care according to claim 1 or 2 any one, its feature in, the extracting method of described Rhizoma Polygoni Cuspidati extract is: the rhizome getting Rhizoma Polygoni Cuspidati drying, 30-40 object coarse powder is ground into pulverizer after section, put into enzymatic vessel, add the pure water of 6 times amount, add the cellulase of 0.25-0.43 part composition by weight again, arranging hydrolysis temperature is 28-40 DEG C, enzymolysis time is 3-5 days, then rapid temperature increases to 85 DEG C enzyme denaturing is lived and is incubated lixiviate 40min, the mass concentration adding 7-9 times amount in gained enzymolysis solution is the alcoholic solution of 63%, heating and refluxing extraction twice, each 2.5h, merge extractive liquid, use macroporous resin column separating-purifying, gained eluent is evaporated to moisture lower than 3%, be ground into fine powder again, cross 150 mesh sieves, obtain Rhizoma Polygoni Cuspidati extract.

5. the preparation method of a kind of external-use lotion for perineal laceration postoperative care according to Claims 1-4 any one, comprises the following steps:

(1) Herba Centellae of drying is got, be placed in dehydrator to dry, arranging bake out temperature is 60-68 DEG C, drying time is 8-10min, again it is ground into 40-60 object coarse powder with disintegrating machine, coarse powder is added in Chinese medicine flash extracter, adding 15 times amount mass concentrations is the alcoholic solution of 82%, extract three times, each 2min, merge extractive liquid, with the ultrafiltration through membranes that aperture is 0.012-0.018 μm, re-use high performance liquid chromatography and carry out purification, the form of sample introduction is adopted repeatedly to improve purity, the liquid pressure-reducing collecting asiaticoside place is concentrated into crystal and separates out, pulverize with crystal pulverizer after dry, cross 170 mesh sieves, obtain asiaticoside, for subsequent use,

(2) rhizome of Rhizoma Polygoni Cuspidati drying is got, 30-40 object coarse powder is ground into pulverizer after section, put into enzymatic vessel, add the pure water of 6 times amount, add the cellulase of 0.25-0.43 part composition by weight again, arranging hydrolysis temperature is 28-40 DEG C, enzymolysis time is 3-5 days, then rapid temperature increases to 85 DEG C enzyme denaturing is lived and is incubated lixiviate 40min, the mass concentration adding 7-9 times amount in gained enzymolysis solution is the alcoholic solution of 63%, heating and refluxing extraction twice, each 2.5h, merge extractive liquid, use macroporous resin column separating-purifying, gained eluent is evaporated to moisture lower than 3%, be ground into fine powder again, cross 150 mesh sieves, obtain Rhizoma Polygoni Cuspidati extract, for subsequent use,

(3) husky seven are taken according to described weight proportion, Radix Berberidis soulieanae, shortleaf peashrub, Folium Vaccinii Fragilis, Rhizoma Paridis tetraphyllae, Bletilla striata (Thunb.ex A.Murray)Rchb.f., Lysimachia christinae Hance dry product, coarse powder is ground into after section, mix homogeneously, the mass concentration being placed in 3 times amount be 60% alcoholic solution soak 7h, the mass concentration adding 7-11 times amount is again the alcoholic solution of 76%, heating and refluxing extraction 3.5h, filter, the mass concentration adding 6-8 times amount again in filtering residue is the alcoholic solution of 73%, reflux, extract, 2.3h, microwave radiation exaraction is adopted while alcohol reflux, arranging microwave frequency is 370-450MHz, filter, merge twice gained filtrate, decompression recycling ethanol, concentrate and obtain the thick paste that proportion is d=1.13-1.27, for subsequent use,

(5) thick paste mixing step (3) and (4) obtained, add the pure water of 7-9 times amount, component meter by weight, add PEG400 4-6 part that mass concentration is 15% again, chlorhexidine acetate 3-5 part, glycerol 2-4 part, press the rotating speed stirring 30min of 450-510r/min with blender after mixing, be placed in homogenizing process 30min in homogenizer again, filter, then add by described composition by weight the Herba Centellae extract and Rhizoma Polygoni Cuspidati extract that step (1) and (2) obtain, mixing and stirring, sterilizing, packaging is sealed up for safekeeping, obtains described external-use lotion.