CN103933393A

CN103933393A - Traditional Chinese medicine for treating suppurative arthritis and preparation method thereof

Info

Publication number: CN103933393A
Application number: CN201410144543.0A
Authority: CN
Inventors: 胡海波
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-04-11
Filing date: 2014-04-11
Publication date: 2014-07-23

Abstract

The invention provides a traditional Chinese medicine for treating suppurative arthritis and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicinal materials: cicada slough, radix puerariae, notopterygium root, rhizome phragmitis, cape jasmine fruit, coptis, radix scrophulariae, moutan bark, honeysuckle, buffalo horn, indigo naturalis, Artemisia ordosica, uniflower swisscentaury root, sargentgloryvine stem, bear gall, gentian macrophylla, ramulus mori, erythrina indica lam, erodium stephanianum wild, parasitic loranthus, Szechwan chinaberry fruit, dutchmanspipe root, long stephania herb, whitebackleaf mallotus root, trachelioides, mysorethorn and filifolium sibiricum. The traditional Chinese medicine has the beneficial effects of stopping pain, clearing heat and removing toxicity, can reach focus directly and is short in treatment course, the suppurative arthritis is unlikely to recur after healing, and the immunity of the organism can be improved. Besides, the traditional Chinese medicine has the characteristics of simple and convenient preparation process, low toxic and side effects and low cost, and is unlikely to generate drug resistance, and the suppurative arthritis is unlikely to recur after healing.

Description

A kind of Chinese medicine and preparation method for the treatment of suppurative arthritis

Technical field

The present invention relates to pharmaceutical technology, relate in particular to a kind of Chinese medicine and preparation method for the treatment of suppurative arthritis.

Background technology

Suppurative arthritis is a kind of by suppurative bacterium direct infection, and causes the arthritis of destruction of joint and afunction, claims again bacterial arthritis or septicemia arthritis.Any age all can fall ill, but is apt to occur in child, oldaged physically weak and chronic joint disease patient, and male is in the majority, ratio 2～3:1 of men and women.That gets involved mostly is the single large joint of limbs, as hip joint, and knee joint and elbow joint etc.As being firearm damage, determine according to injury, generally knee joint, elbow joint incidence rate are higher.

More than 50% pathogenic bacterium are gold-coloured staphylococci, are secondly streptococcus, Diplococcus pneumoniae, escherichia coli, hemophilus influenza etc.Infection is infected the most common with haematogenous, antibacterial can directly enter joint by the infection of joint puncture, operation, damage or joint adjacent tissue in addition.Haematogenous infects the complication that also can be febris acuta, as measles, scarlet fever, pneumonia etc., is more common in child.Traumatic causer, belongs to open injury more, and especially wound does not obtain in the situation of suitable processing and easily occurs.Contiguous infection focus is as Acute osteomyelitis, can direct extension to joint.

Suppurative arthritis acute stage cardinal symptom is poisoning performance: patient is prominent has shiver with cold high hot, and General Symptoms is serious, and pediatric patient Yin Gaore can cause tic.There is the performance of the acute inflammation such as congestion and swelling pain and obvious tenderness part.Joint fluid increases, and has fluctuation, and this as knee joint is more obvious, has that patella is floating to be levied in the shallow joint of table.Patient is often placed in knee joint half bending position, makes loosening of articular capsule, to alleviate tension force.As long-term flexing, will there is joint flexion contracture, joint is slightly moving pain, has protectiveness muscle spasm.

The method for the treatment of suppurative arthritis mainly contains at present:

1. general treatment

(1) fluid infusion is to correct water, electrolyte disturbance.

(2) adopt skin traction or Gypsum Fibrosum supporting plate by immobilization of the wounded limb in functional position.

(3) actively take exercise.

(4) arthrocentesiS drain, uses normal saline flushing.

2. Drug therapy

(1) use effective antibiotics acute stage, need intravenously administrable, after infection control, change into oral.

(2) arthrocentesiS drawing liquid, rush Xian, inject effective antibiotics, to joint without sepage till.

3. operative treatment

(1) should carry out the primary surgical management prevention infection of joint.

(2) topical therapeutic comprises arthrocentesiS, immobilization of the wounded limb and surgical incision and drainage etc.As be closure person, should extract joint fluid out as far as possible, the antibiotic that reinjects, carry out once every day.As being pus or hinder postoperative infection, incision and drainage early, wound also can be with antibacterials instil drainage processing or local wet dressing, as early as possible infection control.Suffering limb should suitably be fixed or draw, the diffusion of avoiding infection, and keep POF.Prevent contracture deformity, or correct existing deformity, once acute inflammation subsides or wound healing start the automatic and slight passive activity in joint, to recover the mobility in joint.But also not movable too early or too much, in order to avoid symptomatic recurrence.

But western modern medicine treatment suppurative arthritis is longer the course for the treatment of, curative effect is not satisfactory, easily produces drug resistance, and even delay treatment produces deformity.The traditional Chinese medical science not only has the treatment feature of doctor trained in Western medicine, from entirety, carries out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the focus of going directly, and treatment short treating period, is not easy recurrence after healing, can improve immunity of organisms simultaneously; And processing technology is easy, there is toxic and side effects little, the feature that cost price is cheap, is difficult for producing drug resistance, is difficult for more afterwards the advantage of recurrence.

Summary of the invention

Technical problem to be solved by this invention is, a kind of effect with relieving spasm to stop pain, heat-clearing and toxic substances removing is provided, and cures mainly suppurative arthritis, the focus of going directly, and treatment short treating period, is not easy recurrence after healing, can improve the new drug of immunity of organisms simultaneously; And processing technology is easy, there is toxic and side effects little, the feature that cost price is cheap, is difficult for producing drug resistance, is difficult for more afterwards the advantage of recurrence.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of suppurative arthritis, wherein, Chinese medicine comprises following raw medicinal material: Periostracum Cicadae, Radix Puerariae, Rhizoma Et Radix Notopterygii, Rhizoma Phragmitis, Fructus Gardeniae, Rhizoma Coptidis, Radix Scrophulariae, Cortex Moutan, Flos Lonicerae, Cornu Bubali, Indigo Naturalis, Herba artemisiae ordosicae, Radix Rhapontici, Caulis Sargentodoxae, Fel Ursi, Radix Gentianae Macrophyllae, Ramulus Mori, Cortex erythrinae, geranium, Herba Taxilli, Fructus Toosendan, Radix Aristolochiae, Herba Stephaniae Longae, Folium Malloti Apeltae, Radix Adenophorae Trachelioidis, Semen Caesalpiniae and rabbit hair Artemisia.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Periostracum Cicadae 12-26 part, Radix Puerariae 21-35 part, Rhizoma Et Radix Notopterygii 9-19 part, Rhizoma Phragmitis 10-20 part, Fructus Gardeniae 12-23 part, Rhizoma Coptidis 11-22 part, Radix Scrophulariae 13-25 part, Cortex Moutan 9-22 part, Flos Lonicerae 16-35 part, Cornu Bubali 14-28 part, Indigo Naturalis 15-24 part, Herba artemisiae ordosicae 18-31 part, Radix Rhapontici 23-36 part, Caulis Sargentodoxae 16-29 part, Fel Ursi 21-32 part, Radix Gentianae Macrophyllae 24-36 part, Ramulus Mori 23-34 part, Cortex erythrinae 13-22 part, geranium 26-34 part, Herba Taxilli 7-17 part, Fructus Toosendan 29-39 part, Radix Aristolochiae 32-39 part, Herba Stephaniae Longae 12-25 part, Folium Malloti Apeltae 17-36 part, Radix Adenophorae Trachelioidis 23-35 part, Semen Caesalpiniae 24-36 part and rabbit hair Artemisia 19-30 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Periostracum Cicadae 14-22 part, Radix Puerariae 23-31 part, Rhizoma Et Radix Notopterygii 11-17 part, Rhizoma Phragmitis 12-18 part, Fructus Gardeniae 14-21 part, Rhizoma Coptidis 14-19 part, Radix Scrophulariae 15-22 part, Cortex Moutan 12-20 part, Flos Lonicerae 19-28 part, Cornu Bubali 18-24 part, Indigo Naturalis 18-21 part, Herba artemisiae ordosicae 21-28 part, Radix Rhapontici 25-32 part, Caulis Sargentodoxae 18-25 part, Fel Ursi 25-30 part, Radix Gentianae Macrophyllae 26-32 part, Ramulus Mori 27-33 part, Cortex erythrinae 15-20 part, geranium 28-33 part, Herba Taxilli 10-16 part, Fructus Toosendan 33-38 part, Radix Aristolochiae 34-37 part, Herba Stephaniae Longae 15-22 part, Folium Malloti Apeltae 19-33 part, Radix Adenophorae Trachelioidis 25-32 part, Semen Caesalpiniae 26-33 part and rabbit hair Artemisia 21-28 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: 25 parts of 18 parts of Periostracum Cicadaes, 26 parts of Radix Puerariaes, 14 parts of Rhizoma Et Radix Notopterygiis, 15 parts of Rhizoma Phragmitiss, 18 parts of Fructus Gardeniaes, 16 parts of Rhizoma Coptidis, 19 parts of Radix Scrophulariaes, 18 parts of Cortex Moutans, 24 parts of Flos Loniceraes, 20 parts of Cornu Bubalis, 19 parts of Indigo Naturaliss, 25 parts of Herba artemisiae ordosicae, 28 parts of Radix Rhapontici, 22 parts of Caulis Sargentodoxae, 27 parts of Fel Ursis, 29 parts of Radix Gentianae Macrophyllae, 30 parts of Ramulus Moris, 17 parts of Cortex erythrinaes, 30 parts of geranium, 13 parts of Herba Taxillis, 35 parts of Fructus Toosendans, 36 parts of Radix Aristolochiaes, 18 parts of Herba Stephaniae Longaes, 28 parts of 26 parts of, Radix Adenophorae Trachelioidis of Folium Malloti Apeltae, 29 parts of Semen Caesalpiniae and rabbit hair Artemisias.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: 26 parts of 20 parts of Periostracum Cicadaes, 28 parts of Radix Puerariaes, 13 parts of Rhizoma Et Radix Notopterygiis, 14 parts of Rhizoma Phragmitiss, 17 parts of Fructus Gardeniaes, 18 parts of Rhizoma Coptidis, 16 parts of Radix Scrophulariaes, 14 parts of Cortex Moutans, 22 parts of Flos Loniceraes, 21 parts of Cornu Bubalis, 20 parts of Indigo Naturaliss, 23 parts of Herba artemisiae ordosicae, 30 parts of Radix Rhapontici, 20 parts of Caulis Sargentodoxae, 28 parts of Fel Ursis, 27 parts of Radix Gentianae Macrophyllae, 29 parts of Ramulus Moris, 18 parts of Cortex erythrinaes, 31 parts of geranium, 14 parts of Herba Taxillis, 36 parts of Fructus Toosendans, 35 parts of Radix Aristolochiaes, 20 parts of Herba Stephaniae Longaes, 30 parts of 22 parts of, Radix Adenophorae Trachelioidis of Folium Malloti Apeltae, 31 parts of Semen Caesalpiniae and rabbit hair Artemisias.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: 22 parts of 16 parts of Periostracum Cicadaes, 24 parts of Radix Puerariaes, 15 parts of Rhizoma Et Radix Notopterygiis, 16 parts of Rhizoma Phragmitiss, 19 parts of Fructus Gardeniaes, 17 parts of Rhizoma Coptidis, 20 parts of Radix Scrophulariaes, 15 parts of Cortex Moutans, 27 parts of Flos Loniceraes, 22 parts of Cornu Bubalis, 21 parts of Indigo Naturaliss, 26 parts of Herba artemisiae ordosicae, 27 parts of Radix Rhapontici, 24 parts of Caulis Sargentodoxae, 25 parts of Fel Ursis, 30 parts of Radix Gentianae Macrophyllae, 32 parts of Ramulus Moris, 15 parts of Cortex erythrinaes, 32 parts of geranium, 11 parts of Herba Taxillis, 37 parts of Fructus Toosendans, 34 parts of Radix Aristolochiaes, 15 parts of Herba Stephaniae Longaes, 29 parts of 30 parts of, Radix Adenophorae Trachelioidis of Folium Malloti Apeltae, 27 parts of Semen Caesalpiniae and rabbit hair Artemisias.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine for the treatment of suppurative arthritis, and wherein, in the time that the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, Periostracum Cicadae, Radix Puerariae, Rhizoma Et Radix Notopterygii, Rhizoma Phragmitis, Fructus Gardeniae, Rhizoma Coptidis, Radix Scrophulariae and Cortex Moutan are mixed in described ratio, add the water extraction volatile oil with respect to 4～6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtaining, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 30 DEG C～50 DEG C of temperature 60 minutes～90 minutes, obtain volatile oil clathrate compound, for subsequent use; The clear paste that while separately aqueous extract being concentrated into 60 DEG C, relative density is 1.15～1.17;

Second step, Flos Lonicerae, Cornu Bubali, Indigo Naturalis, Herba artemisiae ordosicae, Radix Rhapontici, Caulis Sargentodoxae, Fel Ursi, Radix Gentianae Macrophyllae and Ramulus Mori are mixed in described ratio, the alcohol reflux that to add with respect to 5～8 times, mixture amount determining alcohols be 75%～90% 3～5 times, each 2～3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, the clear paste that while being concentrated into 60 DEG C, relative density is 1.20～1.22, for subsequent use;

The 3rd step, will remain described raw medicinal material and mix in described ratio, add with respect to 8～10 times of water gagings of mixture, boil 6～8 hours, filter the clear paste that while being concentrated into 60 DEG C, relative density is 1.28～1.30;

The 4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum are dry, and powder gets dry extract;

The 5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～7 weight portion carboxymethyl starch sodium, 5～50 weight portion starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, then pack in gelatine capsule.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine for the treatment of suppurative arthritis, and wherein, in the time that the dosage form of described Chinese medicine is patch, its preparation method comprises the following steps:

The first step, Periostracum Cicadae, Radix Puerariae, Rhizoma Et Radix Notopterygii, Rhizoma Phragmitis, Fructus Gardeniae, Rhizoma Coptidis, Radix Scrophulariae, Cortex Moutan, Flos Lonicerae, Cornu Bubali and Indigo Naturalis are mixed in described ratio, use the soak with ethanol with respect to the determining alcohol 85%～95% of 3～5 times of the mixture quality obtaining, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the soak with ethanol with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Herba artemisiae ordosicae, Radix Rhapontici, Caulis Sargentodoxae, Fel Ursi, Radix Gentianae Macrophyllae, Ramulus Mori, Cortex erythrinae, geranium and Herba Taxilli are mixed in described ratio, add with respect to obtain mixture quality the determining alcohol 85%～95% of 2～4 times alcohol heating reflux extract 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 60 DEG C～70 DEG C, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water soaking of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water soaking of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and adds with respect to the rubber of 1～2 times of described mixture of powders sum, the Colophonium of 1～2 times, mixes, and makes coating, is coated with cream, cut off, lid lining, section, obtains described patch.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine for the treatment of suppurative arthritis, and wherein, in the time that the dosage form of described Chinese medicine is liniment, its preparation method comprises the following steps:

Step 1: first described raw medicinal material is ground into coarse powder, more further pulverizes, cross 100 mesh sieves, the fine powder amount that enable pass is crossed 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: can not drop into multi-function extractor by the coarse powder of 100 mesh sieves and extract twice, and add for the first time weight portion 8-10 times of water gaging and decoct 1-3 hour, and add for the second time weight portion 6-10 times of water gaging and decoct 1-3 hour, and merge twice decocting liquid, and filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, puts into after 80 DEG C of oven dry of baking oven, room temperature is cooling, grinds to form fine powder b;

Step 3: call in the glycerol that accounts for a and b mixture gross mass 10% after fine powder a is mixed with fine powder b and make liniment.

For solving the problems of the technologies described above, the present invention also provides a kind of dosage form for the treatment of suppurative arthritis Chinese medicine composition, and endo-medicine dosage form is preferably: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup; External used medicine dosage form is preferably: fumigant, ointment, liniment, tincture, ointment, powder, patch, gel and spray.

Described Chinese medicine composition, medicine is decocted in use decoction and is taken, and 1 dose of every day, decocting takes at twice, within every 7 days, is a course for the treatment of; When this Chinese medicine composition be pill, when sucking agent, capsule or tablet and using, 2 times on the one every 9 days is a course for the treatment of; After drug decocting, make spray, ointment, liniment, tincture, patch, ointment, 2-3 time on the one every 7 days is 1 course for the treatment of.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: utilize the traditional theory of Chinese medical science of China, taking relieving spasm to stop pain, heat-clearing and toxic substances removing as main, a kind of Chinese medicine for the treatment of purulent arthritis is provided, the through focus of energy, treatment short treating period, after healing, be not easy recurrence, can improve the advantage of immunity of organisms simultaneously; And processing technology is easy, there is toxic and side effects little, the feature that cost price is cheap, is difficult for producing drug resistance, is difficult for more afterwards the advantage of recurrence.

Detailed description of the invention

Motherland's medical science is thought, bone, general reference human skeleton.Bone has storage bone marrow, supports the function of body and protection internal organs.The property that bone tool is hard firm, is the support of the person, can support body, and protection internal organs, therefore cloud: " bone is for dry " (" Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates ").Human body is taking skeleton as trunk, and bone supports figure, and make human body maintain certain form, and defend the damage of external force to internal organs, thus performance protective effect.So bone can be supported body, rely in fact the nutrition in bone marrow, bone to obtain marrow and support, just can maintain its tough and tensile firm property.If marrow loss, bone is become homeless foster, and there will be can not standing for a long time, the time of tottering while walking.Bone is the important component part of human motion system.The contraction tension and relaxation of muscle and muscle, impels joint bend and stretch or rotate, thereby shows as the motion of body.In motor process, bone and the joint being made up of bone have been played fulcrum and have been supported and the concrete important function such as action of implementing.So all motions all be unable to do without the effect of skeleton.: " bone person, fu-viscera of marrow " (" Plain Questions arteries and veins is wanted precise and tiny opinion ").Bone is marrow mansion, and marrow is hidden in bone, and bone has the effect of storage bone marrow thus.The bone marrow skeleton of supplementing nutrition.It is all relevant with the profit and loss of marrow that the heavily fortified point of growth, growth and the sclerotin of bone is crisp etc.Bone marrow is full, and skeleton must be supported, and skeleton is energetic.Otherwise, there will be the ANOMALOUS VARIATIONS of growth promoter and the sclerotin of bone.

The invention provides a kind of Chinese medicine for the treatment of suppurative arthritis, wherein, comprise following raw medicinal material: Periostracum Cicadae, Radix Puerariae, Rhizoma Et Radix Notopterygii, Rhizoma Phragmitis, Fructus Gardeniae, Rhizoma Coptidis, Radix Scrophulariae, Cortex Moutan, Flos Lonicerae, Cornu Bubali, Indigo Naturalis, Herba artemisiae ordosicae, Radix Rhapontici, Caulis Sargentodoxae, Fel Ursi, Radix Gentianae Macrophyllae, Ramulus Mori, Cortex erythrinae, geranium, Herba Taxilli, Fructus Toosendan, Radix Aristolochiae, Herba Stephaniae Longae, Folium Malloti Apeltae, Radix Adenophorae Trachelioidis, Semen Caesalpiniae and rabbit hair Artemisia.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Periostracum Cicadae: sweet, cold; Return lung, Liver Channel.Control blurred vision nebula.Controlling children's, to go out skin ulcer rash unhappy.Control phlegm-accumulating vertigo, skin wind heat, varioliform exanthema is had an itch, tetanus and treatment toxic swelling skin ulcer, adult's aphonia, children's's lockjaw sky hangs, the frightened night cry of crying, swelling of the vulva.Loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms, tetanus.

Radix Puerariae: cool in nature, sweet in the mouth, pungent, enters spleen, stomach warp.Cure mainly: quench one's thirst, high fever of the body, vomiting, all frauds, play cloudy gas, separate all poison.Can yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cold, the warm headache stiffness of the nape that cures the wound, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.

Rhizoma Et Radix Notopterygii: acrid in the mouth, hardship, warm in nature; Enter bladder, kidney channel.Control harmful wind, aphonia in silence, the blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, insensitive impediment all over more.Main all joints being painful all over, flesh table eight winds coming from eight orientations harmful climatic factors, except new and old rheumatism, row's slough cellulitis skin ulcer.The function exterior cold of faling apart, wind-damp dispelling, sharp joint, pain relieving.Main affection of exogenous wind-cold, has a headache lossless, edema due to wind pathogen edema, sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.The cold expelling that induces sweat, expelling wind and dampness, pain relieving.

Rhizoma Phragmitis: sweet, cold; Return lung meridian, stomach warp.Can separate large heat, appetizing.Control the sound of vomiting of choking more than.Disease unhappiness while controlling cold and heat, good pregnant people's heat in the heart, and dysentery people is thirsty.Clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.

Fructus Gardeniae: bitter, cold, nontoxic; Enter heart channel, Liver Channel, lung meridian, stomach warp, tri-jiao channel.Main five interior pathogens, pathogenic heat in the stomach gas, flushed complexion wine acne vulgaris nose, the red impetigo infections of tuberculoid leprosy.Cure mainly the hot swelling pain of order, the large heat of breast heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, and headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprains and swells and ache.

Rhizoma Coptidis: hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing pathogen in the heart stomach, has the disappear merit of painful abdominal mass of preventing or arresting vomiting concurrently, can be used for treating the dysphoria and insomnia of heart-fire due to prosperous, and heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.

Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel.Control wind syndrome of head pyretic toxicity urticaria, tonify deficiency strain, the heart is frightened irritated, and bad weary hectic fever due to YIN-deficiency passes corpse pathogen, only forgetful, detumescence poison.There is clearing away heat and cooling blood, eliminating fire and detoxication, effect of YIN nourishing, cures mainly warm febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, the cards such as constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore are not hindered in awake, Tianjin to send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency.

Cortex Moutan: bitter in the mouth, pungent, cold nature, enters the heart, liver, kidney channel.Have the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in treating the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, hot Fu Yin of calentura later stage divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, rheumatism pyretic arthralgia.

Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency and treats effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.

Cornu Bubali: bitter salty, cold.Enter the heart, liver, spleen, stomach four warps.Removing pathogenic heat from blood and toxic substance from the body, only nosebleed.Control calentura stupor, numb pox macule, spits blood, epistaxis, heat in blood, dark coloured urine.Heat clearing away, removing heat from blood, removing toxic substances.Control calentura headache, high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.

Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel, there is effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, send out the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms for epidemic febrile disease, Indigo Naturalis, containing indigo, indirubin, has heat-clearing and toxic substances removing, the antiviral effect of sore, inhibited to cholera bacilli, Bacillus typhi, dysentery bacterium and part virus.

Herba artemisiae ordosicae: acrid in the mouth; Bitter; Slightly warm in nature.Expelling wind and removing dampness; Removing toxic substances and promoting subsidence of swelling.Main air wet arthritis; Headache due to common cold; Laryngopharynx swelling and pain; Carbuncle furuncle.

Radix Rhapontici: bitter in the mouth is salty, cold; Enter stomach, large intestine channel.Hardship can be let out down, salty can softening the hard mass, cold can heat extraction, the medicine of cold and tonneau is also.Therefore main skin heat, malignant boil cellulitis hemorrhoid, arthralgia chiefly caused by damp pathogen, lower milk.Heat-clearing and toxic substances removing, evacuation of pus detumescence, eliminating carbuncle, stimulating milk secretion, relaxing muscles and tendons is promoted blood circulation.Swell and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture, arthralgia, toxic-heat and blood stasis, bleeding hemorrhoids.

Caulis Sargentodoxae: bitter in the mouth, property is flat, returns liver, large intestine channel, stimulates the menstrual flow and enriches blood, bone and muscle strengthening, anthelmintic.Control traumatic injury, rheumatalgia, bruise, stranguria with blood, bones and muscles pain, furuncle, filaricide.Control bones and muscles pain, chase after wind, strong waist knee joint, tonifying YANG thing.There is the eliminating carbuncle of relieving internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.

Fel Ursi: bitter, cold; Heat-clearing and toxic substances removing, improving eyesight, relieving convulsion.Heat-clearing and toxic substances removing, improving eyesight, relieving convulsion.For excessive heat of infant infantile convulsion, epilepsy, twitch.

Radix Gentianae Macrophyllae: pungent, bitter, be slightly cold.Return stomach warp, Liver Channel, gallbladder meridian.Can treat wind, new for a long time without asking, the whole body contraction is anxious.Eradicates rheumatism, relaxing muscles and tendons network, clearind deficient heat.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, infantile malnutrition heating.Rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, newly for a long time all can compatibility application without inquiring about chills and fever.

Ramulus Mori: sweet, flat, nontoxic.Tonify deficiency QI invigorating, gas anhydrates.Folium Mori blood pressure lowering, liver heat removing and eyesight improving.RAMULUS MORI curing rheumatism, controls brachialgia.

Cortex erythrinae: toil, flat.Enter liver, spleen channel.Main cholera attacked by pestiferous factors, red white chronic dysentery, except sweetly hideing, scabies.Tooth worm pain, and boil clothes and contain it, order is washed in water logging, removes skin red.Main waist foot is unsuccessful, insensitive impediment lower limb knee joint pain, cholera, red white dysentery, dysentery, scabies.Wind-damp dispelling, the meridian dredging, parasite killing.

Geranium: bitter in the mouth, puckery, property is flat, GUIXIN, Liver Channel, control married woman's menstruation or before or after, leucorrhea with red and white discharge, the cold stomachache of face, with the passing of time red white dysentery.The therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness; Traumatic injury is spitted blood, metrorrhagia, dysentery, discharging fresh blood stool.Astringing to arrest bleeding, dysentery relieving, parasite killing.

Herba Taxilli: hardship; Sweet; Property is put down.Enter liver, kidney channel.Main incised wound, goes numbness, woman's metrorrhagia, internal injury deficiency, puerperal remaining disease, lower milk.The heat that disappears, nourishing, chases after wind.The heat radiation of nourishing blood, makes tea-drinking, relaxing muscles and tendons and activating QI and blood in the collateral.Can invigorating the liver and kidney; Bone and muscle strengthening; Wind-damp dispelling; Antiabortive.Main soreness of waist and knee joint; A little less than muscles and bones flaccidity; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and metrorrhagia warp is many, blood leaking in gestation, frequent fetal movement; Hypertension.

Fructus Toosendan: cold in nature, bitter in the mouth, slightly poisonous.Return liver, small intestinal, urinary bladder channel.In owner, large heat, mad, loses the heart hot-tempered vexed, makes soup and bathe.Eliminating heart-fire, hard kidney water, lung heat clearing gold, clearing away liver-fire.Core: happy hernia, remove syndrome of aversion to cold lasting day and night with cold limbs.Function soothing liver-QI, promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.

Radix Aristolochiae: arduous, cold.Enter lung, stomach warp.Main gathering.All scorchingly hot swollen, snake venom, water rub into mudding it, days three, four; Treat furuncle enlargement effect.Deliver, except wind.The paralysis of (controlling) rheumatism, waist foot pain, traumatic injury.Circulation of qi promoting, removing toxic substances, detumescence.Control chest and abdomen swelling and pain, acute filthy disease, enteritis dysentery, hypertension, hernia, Serpentis stings poison, carbuncle, furuncle, skin pruritus or wet rotten.

Herba Stephaniae Longae: micro-hardship, puckery, flat.Return liver, gallbladder, large intestine channel.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.For pyelonephritis, cystitis, chronic nephritis, enteritis, dysentery, venom; Carbuncle furuncle infections, suppurative otitis media are controlled in external.

Folium Malloti Apeltae: micro-hardship, puckery, flat.Return liver, spleen channel.Anti-inflammation hemostasia, heat clearing away, dampness removing, pain relieving, removing toxic substances, hemostasis, controls stranguria with turbid discharge, stomachache, aphtha, hemorrhoid, ulcer, traumatic injury, venom, traumatic hemorrhage.

Radix Adenophorae Trachelioidis: sweet, cold.Return lung, spleen channel.Heat clearing away, removing toxic substances, reduces phlegm.Control cough caused by dryness, laryngalgia, quenches one's thirst, furuncle swelling toxin.

Semen Caesalpiniae: pungent; Bitter; Temperature.Return lung; Large intestine channel.Removing toxic substances dehumidifying, relieving cough and resolving phlegm, parasite killing.Main dysentery, malaria chronic tracheitis, infantile malnutrition, malnutrition due to parasitic infestation, rheumatalgia, traumatic injury.

Rabbit hair Artemisia: hardship, cold.Heat-clearing and toxic substances removing, anti-inflammation, calms the nerves relieving convulsion, regulating menstruation, hemostasis.Cure mainly the high heat of infectious disease, take orally heart beating, insomnia, neurasthenia's effect are being shown, to menorrhagia, menoxenia also has certain curative effect.Swollen carbuncle is controlled in external, ecthyma (chronic ulcer of lower extremity), otitis media and other surgery pyogenic infection disease.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine for the treatment of suppurative arthritis, and when the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine for the treatment of suppurative arthritis, and when the dosage form of described external used medicine is patch, its preparation method comprises the following steps:

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine for the treatment of suppurative arthritis, and when the dosage form of described Chinese medicine preparation is liniment, its preparation method comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 capsule of the present invention

The embodiment of the present invention provides a kind of Chinese medicine for the treatment of suppurative arthritis, is made by the raw medicinal material of following weight: Periostracum Cicadae 20g, Radix Puerariae 28g, Rhizoma Et Radix Notopterygii 13g, Rhizoma Phragmitis 14g, Fructus Gardeniae 17g, Rhizoma Coptidis 18g, Radix Scrophulariae 16g, Cortex Moutan 14g, Flos Lonicerae 22g, Cornu Bubali 21g, Indigo Naturalis 20g, Herba artemisiae ordosicae 23g, Radix Rhapontici 30g, Caulis Sargentodoxae 20g, Fel Ursi 28g, Radix Gentianae Macrophyllae 27g, Ramulus Mori 29g, Cortex erythrinae 18g, geranium 31g, Herba Taxilli 14g, Fructus Toosendan 36g, Radix Aristolochiae 35g, Herba Stephaniae Longae 20g, Folium Malloti Apeltae 22g, Radix Adenophorae Trachelioidis 30g, Semen Caesalpiniae 31g and rabbit hair Artemisia 26g.

Its preparation method comprises the following steps:

The first step, Periostracum Cicadae, Radix Puerariae, Rhizoma Et Radix Notopterygii, Rhizoma Phragmitis, Fructus Gardeniae, Rhizoma Coptidis, Radix Scrophulariae and Cortex Moutan are mixed in described ratio, add the water extraction volatile oil with respect to 4 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtaining, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 40 DEG C of temperature 80 minutes, obtain volatile oil clathrate compound, for subsequent use; The clear paste that while separately aqueous extract being concentrated into 60 DEG C, relative density is 1.17;

Second step, Flos Lonicerae, Cornu Bubali, Indigo Naturalis, Herba artemisiae ordosicae, Radix Rhapontici, Caulis Sargentodoxae, Fel Ursi, Radix Gentianae Macrophyllae and Ramulus Mori are mixed in described ratio, the alcohol reflux that to add with respect to 5～8 times, mixture amount determining alcohols be 80% 3 times, each 2 hours, filter respectively, each time filtrate merges, and reclaims ethanol, the clear paste that while being concentrated into 60 DEG C, relative density is 1.20, for subsequent use;

The 3rd step, will remain described raw medicinal material and mix in described ratio, add with respect to 8 times of water gagings of mixture, boil 6 hours, filter the clear paste that while being concentrated into 60 DEG C, relative density is 1.30;

The 4th step, mixes the clear paste of the first step, second step, the 3rd step, and 70 DEG C of reduced vacuum are dry, and powder gets dry extract;

The 5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 7 weight portion carboxymethyl starch sodium, 35 weight portion starch mix homogeneously, adding 150 weight portion determining alcohols is 90% alcohol granulation, dry, granulate, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 4 weight portion magnesium stearate, then pack in gelatine capsule.

Embodiment 2 patch of the present invention

The embodiment of the present invention provides a kind of Chinese medicine for the treatment of suppurative arthritis, is made by the raw medicinal material of following weight: Periostracum Cicadae 18g, Radix Puerariae 26g, Rhizoma Et Radix Notopterygii 14g, Rhizoma Phragmitis 15g, Fructus Gardeniae 18g, Rhizoma Coptidis 16g, Radix Scrophulariae 19g, Cortex Moutan 18g, Flos Lonicerae 24g, Cornu Bubali 20g, Indigo Naturalis 19g, Herba artemisiae ordosicae 25g, Radix Rhapontici 28g, Caulis Sargentodoxae 22g, Fel Ursi 27g, Radix Gentianae Macrophyllae 29g, Ramulus Mori 30g, Cortex erythrinae 17g, geranium 30g, Herba Taxilli 13g, Fructus Toosendan 35g, Radix Aristolochiae 36g, Herba Stephaniae Longae 18g, Folium Malloti Apeltae 26g, Radix Adenophorae Trachelioidis 28g, Semen Caesalpiniae 29g and rabbit hair Artemisia 25g.

Its preparation method comprises the following steps:

The first step, Periostracum Cicadae, Radix Puerariae, Rhizoma Et Radix Notopterygii, Rhizoma Phragmitis, Fructus Gardeniae, Rhizoma Coptidis, Radix Scrophulariae, Cortex Moutan, Flos Lonicerae, Cornu Bubali and Indigo Naturalis are mixed in described ratio, use the soak with ethanol with respect to the determining alcohol 895% of 3～5 times of the mixture quality obtaining, reflux was extracted after 4 hours, filter, obtain the first filtrate; Filtering residue is used to the soak with ethanol with respect to the determining alcohol 95% of 1 times of the mixture quality obtaining again, and reflux was extracted after 1 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Herba artemisiae ordosicae, Radix Rhapontici, Caulis Sargentodoxae, Fel Ursi, Radix Gentianae Macrophyllae, Ramulus Mori, Cortex erythrinae, geranium and Herba Taxilli are mixed in described ratio, add with respect to obtain mixture quality the determining alcohol 85% of 2 times alcohol heating reflux extract 1 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 70 DEG C, relative density is 1.20, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water soaking of 2 times with respect to the mixture quality obtaining, and heating decocts 3 hours, filters; Filtering residue is used to the water soaking of 2 times with respect to the mixture quality obtaining again, and heating decocts 2 hours, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and adds with respect to the rubber of 1 times of described mixture of powders sum, the Colophonium of 2 times, mixes, and makes coating, is coated with cream, cut off, lid lining, section, obtains described patch.

Embodiment 3 liniment of the present invention

The embodiment of the present invention provides a kind of Chinese medicine for the treatment of suppurative arthritis, is made by the raw medicinal material of following weight: Periostracum Cicadae 16g, Radix Puerariae 24g, Rhizoma Et Radix Notopterygii 15g, Rhizoma Phragmitis 16g, Fructus Gardeniae 19g, Rhizoma Coptidis 17g, Radix Scrophulariae 20g, Cortex Moutan 15g, Flos Lonicerae 27g, Cornu Bubali 22g, Indigo Naturalis 21g, Herba artemisiae ordosicae 26g, Radix Rhapontici 27g, Caulis Sargentodoxae 24g, Fel Ursi 25g, Radix Gentianae Macrophyllae 30g, Ramulus Mori 32g, Cortex erythrinae 15g, geranium 32g, Herba Taxilli 11g, Fructus Toosendan 37g, Radix Aristolochiae 34g, Herba Stephaniae Longae 15g, Folium Malloti Apeltae 30g, Radix Adenophorae Trachelioidis 29g, Semen Caesalpiniae 27g and rabbit hair Artemisia 22g.

Its preparation method comprises the following steps:

Step 2: can not drop into multi-function extractor by the coarse powder of 100 mesh sieves and extract twice, and add for the first time 8 times of water gagings of weight portion and decoct 3 hours, and add for the second time 10 times of water gagings of weight portion and decoct 2 hours, and merge twice decocting liquid, and filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, puts into after 80 DEG C of oven dry of baking oven, room temperature is cooling, grinds to form fine powder b;

Acute skin irritation test:

These product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg～3kg, patch prepared by embodiments of the invention 2 is directly attached on the skin of animal left side (opposite side in contrast), adopt blocking test, 4 hours application time, after off-test, use the residual tested material of warm water washing, 1h after removing tested material, 24h, 48h and 72h observe respectively the dermoreaction of the tested district of animal and check plot, top average is " 0 ", judge that these product are to animal skin nonirritant.

Hypersensitive test:

Get 18 of healthy albino guinea-pigs, body weight 250-300g, male and female dual-purpose, rejects both sides dorsal body setae before test, and every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration; The liniment of the embodiment of the present invention 3 for test group.The liniment 0.1g that gets the embodiment of the present invention 3 is applied to unhairing district, back, the next day 1 time, totally 3 times.Contact latter 14 days in last, smear this product 0.1g at back the same area, after 6h, remove after medicine and at once observe, and in 24,48,72h observes and has or not anaphylaxis.Blank group is used same method to excite with positive controls and is contacted and observe.Result of the test: localized erythema and slight edema appear in positive controls animal skin after 1 hour in sensitization, within 24 hours, symptoms of allergic increases the weight of, and there is scleroma to form, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Acute toxicity test:

40 of application NIH mices, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; Capsule prepared by embodiments of the invention 1 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage capsule LD50>32.9 of the present invention crude drug/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.4g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is taking 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity.Therefore the capsule acute toxicity of the embodiment of the present invention 2 is low, clinical drug safety.

Long term toxicity test:

The capsule of the embodiment of the present invention 1 to mice by 10.78,20.35 and 16 weeks (1.0ml/100g body weight of 33.48g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.The capsule that the embodiment of the present invention 2 is described to mice long-term prescription after toxicity little, after drug withdrawal, there is no difference reaction, application safety yet.

Clinical data:

This group of physical data is totally 117 people, and wherein child's 39 examples, are male, 3.5～14 years old age, average 10 years old; 78 examples of being grown up, male 33 examples, female's 45 examples, 17～60 years old age, average 42.3 years old.The course of disease is 3 days～5 years.The joint ratio of getting involved: knee joint is 43. 6 %, hip joint is 30.8 %, and ankle joint is 17.8 %, and elbow, breast lock and metatarsophalangeal joints are 2.6%.92.3% patient shows as simple joint and gets involved, and all the other patients are two joint involvement, and position is double knee joint.

Capsule treatment group: 26 people, male 16 people, female 10 people.

Patch treatment group: 30 people, male 18 people, female 12 people.

Liniment treatment group: 32 people, male 19 people, female 13 people.

Western medicine group: 29 people, male 19 people, female 10 people.

Diagnostic criteria:

(1) General Symptoms: high heat, shiver and vomit; After neonate morbidity, can not generate heat, but performance has dysphoria, refusing to eat and body weight not to increase.(2) local symptom: red, swollen, hot, bitterly; Local puncture can be extracted pus or purulent exudate out.(3) lab testing: blood leukocytes increases and reaches 1. 5 ten thousand～20,000, and neutrophilic granulocyte obviously increases, shift to left, and C reactive protein increases, hemoculture can be positive, and pus is cultivated can be positive.(4) X line is taken the photograph sheet inspection: the early stage rarely seen local soft tissue swelling of X line sheet, the turbid sample of the visible periosteal reaction of 10～14 d and worm destroys, and can have late period sequestrum to form.(5) isotope bone scanning inspection: after morbidity 24～48 h, the visible diseased region isotope enrichment of isotope bone scanning.(6) pathologic finding: show that inflammation changes.

Therapeutic Method:

Treatment by Chinese herbs group:

Capsule treatment group: use the capsule prepared of the embodiment of the present invention 1,2 times on the one, one time 4, within every 9 days, be a course for the treatment of;

Patch treatment group: the patch that uses the embodiment of the present invention 2 to prepare, 3 times on the one every 7 days is 1 course for the treatment of;

Liniment treatment group: the liniment that uses the embodiment of the present invention 3 to prepare, 3 times on the one every 7 days is 1 course for the treatment of;

Western medicine group:

Oral flucloxacillin sodium and amoxicillin capsule, 3 times on the one, one time 2, every 7 days is a course for the treatment of;

Child 3 times on the one, one time 1, every 7 days is a course for the treatment of.

The standard of curative effect evaluation:

Excellent: activity is bent and stretched freely in joint, and gait is normal, pain without;

Good: joint flexing is limited in 20 °, and gait is normal, pain once in a while;

Shang Ke: joint flexing is limited in more than 20 °, gait normal, pain is frequent;

Poor: joint stiffness, gait is walked lamely, and pain is obvious.

Therapeutic outcome:

Referring to table 1, as can be seen from Table 1, adopt treatment by Chinese herbs suppurative arthritis of the present invention patient, on adjuvant treatment effect, there is significant improvement with respect to Western medicine.

Four groups, table 1 is treated respectively Clinical efficacy comparison example (%) after 3 courses for the treatment of

Group	Number of cases	Excellent	Good	Shang Ke	Poor	Acceptance rate
							Capsule treatment group	26	23	2	1	0	96.2%
Patch treatment group	30	24	3	3	0	90.0 %
							Liniment treatment group	32	26	4	2	0	93.8%
Western medicine group	29	18	5	5	1	79.3%

Four groups, table 2 is treated respectively excellent and good number and time comparative example (%) after 3 courses for the treatment of

Group	Number of cases	The 1st course for the treatment of	The 2nd course for the treatment of	The 3rd course for the treatment of
					Capsule treatment group	25	3(12%)	10(40%)	12(48%)
Patch treatment group	27	4(14.8%)	12(44.4%)	11(40.7%)
					Liniment treatment group	30	6(20%)	17(56.7%)	7(23.3%)
Western medicine group	23	1(4.3%)	10(43.5%)	12(52.2%)

Known according to the clinical statistics in above table, Chinese medicine provided by the invention has that effective percentage is high, determined curative effect, safe, the advantage that has no side effect; 25 examples excellent and good to capsule treatment group simultaneously, patch treatment group excellent and good excellent and good 30 examples and the 23 excellent and good routine patients of western medicine group of 27 examples, liniment treatment group follow up a case by regular visits to 8 months, result statistics:

25 examples that capsule treatment group is excellent and good, 23 excellent example nothing recurrences, 1 case relapsed in 2 good routine patients, relapse rate is 4%;

27 examples that patch treatment group is excellent and good, 24 excellent example nothing recurrences, 1 case relapsed in 3 good routine patients, relapse rate is 3.7%;

30 examples that liniment agent treatment group is excellent and good, 26 excellent examples, without recurrence, recur 2 examples in 4 good routine patients, and relapse rate is 6.7%;

The 23 routine patients that western medicine group is excellent and good, recur 2 examples in 18 excellent examples, in 5 good routine patients, recur 2 examples, and relapse rate is 17.4%.

model case:infant, female, in 1 years old February, the right hip joint limitation of activity of main cause hot 7 d that occur together are admitted to hospital.Infant is admitted to hospital first 7 days without obviously inducement appearance heating, body temperature fluctuates at 38 DEG C-39 DEG C, there is the movable minimizing of right lower extremity thereupon, refusal is walked, give febrifuge symptomatic treatment, the rear head of a family finds the right hip joint flexing of infant shape, limitation of activity, human health screening: infant spirit appetite is poor, 38.2 DEG C of body temperature, right lower extremity tripping, right hip joint flexing, right hip joint skin is obviously rubescent, local skin temperature is higher than offside, touch a tender spot (+), when the right hip joint of passive activity, infant is cry and screamed obviously, and when abduction, inward turning and outward turning, pain is obvious.Blood test routine: WBC 22.45 × 109/ L, neutrophilic granulocyte ratio is 68.5%, percentage of lymphocyte is 3 0. 2%, HGB 88 g/L, albumin 38.6 g/L, CR P 50 mg/L, ESR 30 mm/h, right hip joint color ultrasound examination result: right hip joint hypodermis layer thickens.Right hip joint MRI result: a small amount of hydrops of right hip joint, pathological changes is involved femoral head and surrounding soft tissue.2 courses for the treatment of of capsule of oral Chinese medicine of the present invention, check in 3 months, right hip joint is movable normal; Two hip MRI show: right hip joint is without hydrops, and femoral head and metaphysis signal lower.Treat check in latter 1 year, two lower limb are isometric, and right hip joint mobility is normal.

The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. treat the Chinese medicine of suppurative arthritis for one kind, it is characterized in that, comprise following raw medicinal material: Periostracum Cicadae, Radix Puerariae, Rhizoma Et Radix Notopterygii, Rhizoma Phragmitis, Fructus Gardeniae, Rhizoma Coptidis, Radix Scrophulariae, Cortex Moutan, Flos Lonicerae, Cornu Bubali, Indigo Naturalis, Herba artemisiae ordosicae, Radix Rhapontici, Caulis Sargentodoxae, Fel Ursi, Radix Gentianae Macrophyllae, Ramulus Mori, Cortex erythrinae, geranium, Herba Taxilli, Fructus Toosendan, Radix Aristolochiae, Herba Stephaniae Longae, Folium Malloti Apeltae, Radix Adenophorae Trachelioidis, Semen Caesalpiniae and rabbit hair Artemisia.

2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Periostracum Cicadae 12-26 part, Radix Puerariae 21-35 part, Rhizoma Et Radix Notopterygii 9-19 part, Rhizoma Phragmitis 10-20 part, Fructus Gardeniae 12-23 part, Rhizoma Coptidis 11-22 part, Radix Scrophulariae 13-25 part, Cortex Moutan 9-22 part, Flos Lonicerae 16-35 part, Cornu Bubali 14-28 part, Indigo Naturalis 15-24 part, Herba artemisiae ordosicae 18-31 part, Radix Rhapontici 23-36 part, Caulis Sargentodoxae 16-29 part, Fel Ursi 21-32 part, Radix Gentianae Macrophyllae 24-36 part, Ramulus Mori 23-34 part, Cortex erythrinae 13-22 part, geranium 26-34 part, Herba Taxilli 7-17 part, Fructus Toosendan 29-39 part, Radix Aristolochiae 32-39 part, Herba Stephaniae Longae 12-25 part, Folium Malloti Apeltae 17-36 part, Radix Adenophorae Trachelioidis 23-35 part, Semen Caesalpiniae 24-36 part and rabbit hair Artemisia 19-30 part.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Periostracum Cicadae 14-22 part, Radix Puerariae 23-31 part, Rhizoma Et Radix Notopterygii 11-17 part, Rhizoma Phragmitis 12-18 part, Fructus Gardeniae 14-21 part, Rhizoma Coptidis 14-19 part, Radix Scrophulariae 15-22 part, Cortex Moutan 12-20 part, Flos Lonicerae 19-28 part, Cornu Bubali 18-24 part, Indigo Naturalis 18-21 part, Herba artemisiae ordosicae 21-28 part, Radix Rhapontici 25-32 part, Caulis Sargentodoxae 18-25 part, Fel Ursi 25-30 part, Radix Gentianae Macrophyllae 26-32 part, Ramulus Mori 27-33 part, Cortex erythrinae 15-20 part, geranium 28-33 part, Herba Taxilli 10-16 part, Fructus Toosendan 33-38 part, Radix Aristolochiae 34-37 part, Herba Stephaniae Longae 15-22 part, Folium Malloti Apeltae 19-33 part, Radix Adenophorae Trachelioidis 25-32 part, Semen Caesalpiniae 26-33 part and rabbit hair Artemisia 21-28 part.

4. the Chinese medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 18 parts of Periostracum Cicadaes, 26 parts of Radix Puerariaes, 14 parts of Rhizoma Et Radix Notopterygiis, 15 parts of Rhizoma Phragmitiss, 18 parts of Fructus Gardeniaes, 16 parts of Rhizoma Coptidis, 19 parts of Radix Scrophulariaes, 18 parts of Cortex Moutans, 24 parts of Flos Loniceraes, 20 parts of Cornu Bubalis, 19 parts of Indigo Naturaliss, 25 parts of Herba artemisiae ordosicae, 28 parts of Radix Rhapontici, 22 parts of Caulis Sargentodoxae, 27 parts of Fel Ursis, 29 parts of Radix Gentianae Macrophyllae, 30 parts of Ramulus Moris, 17 parts of Cortex erythrinaes, 30 parts of geranium, 13 parts of Herba Taxillis, 35 parts of Fructus Toosendans, 36 parts of Radix Aristolochiaes, 18 parts of Herba Stephaniae Longaes, 26 parts of Folium Malloti Apeltaes, 28 parts of Radix Adenophorae Trachelioidis, 25 parts of 29 parts of Semen Caesalpiniae and rabbit hair Artemisias.

5. the Chinese medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 20 parts of Periostracum Cicadaes, 28 parts of Radix Puerariaes, 13 parts of Rhizoma Et Radix Notopterygiis, 14 parts of Rhizoma Phragmitiss, 17 parts of Fructus Gardeniaes, 18 parts of Rhizoma Coptidis, 16 parts of Radix Scrophulariaes, 14 parts of Cortex Moutans, 22 parts of Flos Loniceraes, 21 parts of Cornu Bubalis, 20 parts of Indigo Naturaliss, 23 parts of Herba artemisiae ordosicae, 30 parts of Radix Rhapontici, 20 parts of Caulis Sargentodoxae, 28 parts of Fel Ursis, 27 parts of Radix Gentianae Macrophyllae, 29 parts of Ramulus Moris, 18 parts of Cortex erythrinaes, 31 parts of geranium, 14 parts of Herba Taxillis, 36 parts of Fructus Toosendans, 35 parts of Radix Aristolochiaes, 20 parts of Herba Stephaniae Longaes, 22 parts of Folium Malloti Apeltaes, 30 parts of Radix Adenophorae Trachelioidis, 26 parts of 31 parts of Semen Caesalpiniae and rabbit hair Artemisias.

6. the Chinese medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 16 parts of Periostracum Cicadaes, 24 parts of Radix Puerariaes, 15 parts of Rhizoma Et Radix Notopterygiis, 16 parts of Rhizoma Phragmitiss, 19 parts of Fructus Gardeniaes, 17 parts of Rhizoma Coptidis, 20 parts of Radix Scrophulariaes, 15 parts of Cortex Moutans, 27 parts of Flos Loniceraes, 22 parts of Cornu Bubalis, 21 parts of Indigo Naturaliss, 26 parts of Herba artemisiae ordosicae, 27 parts of Radix Rhapontici, 24 parts of Caulis Sargentodoxae, 25 parts of Fel Ursis, 30 parts of Radix Gentianae Macrophyllae, 32 parts of Ramulus Moris, 15 parts of Cortex erythrinaes, 32 parts of geranium, 11 parts of Herba Taxillis, 37 parts of Fructus Toosendans, 34 parts of Radix Aristolochiaes, 15 parts of Herba Stephaniae Longaes, 30 parts of Folium Malloti Apeltaes, 29 parts of Radix Adenophorae Trachelioidis, 22 parts of 27 parts of Semen Caesalpiniae and rabbit hair Artemisias.

7. the Chinese medicine as described in as arbitrary in claim 1 to 6, is characterized in that, in the time that the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

8. the Chinese medicine as described in as arbitrary in claim 1 to 6, is characterized in that, in the time that the dosage form of described Chinese medicine is patch, its preparation method comprises the following steps:

9. the Chinese medicine as described in as arbitrary in claim 1 to 6, is characterized in that, in the time that the dosage form of described Chinese medicine is liniment, its preparation method comprises the following steps: