CN105169017A - Traditional Chinese medicine for treating kidney stone and preparation method of traditional Chinese medicine - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating kidney stone and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following raw medicinal materials: hedgehog hide, pomegranate root, lily, Chinese rose leaves, stinkgrass flowers, cowberry leaves, leaf of common aeschynomene, ephedra, rostellularia procumbens, herb of Indian pentanema, herb of chien briggsia, lycopodium clavatum, Indian damnacanthus herb, nightshade, veronicastrum herb, Commelina communis L., calystegia hederacea, splendid achnatherum, stem of moupin dutchmanspipe and medulla stachyuri. The traditional Chinese medicine for treating kidney stone is safe in use, causes no pain, and is free of toxic or side effect, and definite in curative effect, the cure rate and the total effective rate are obviously improved, and the preparation process is simple.

Description

A kind of Chinese medicine for the treatment of renal calculus and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine for the treatment of renal calculus and preparation method thereof.

Background technology

Renal calculus refers to the calculus betiding renal calices, renal pelvis and renal pelvis and ureter coupling part.Majority is positioned at renal pelvis renal calices, and excess of the kidney matter calculus is rare.There is the fine and close shadow of single or multiple circle, oval or obtuse triangle in plain film display kidney district, high and uniform density.How smooth edge is, but also rough in Fructus Mori shape again.Kidney is the lithogenous main portions of urinary system shape, and the calculus at other any positions can betide kidney, and ureteral calculus is almost all from kidney, and renal calculus coup injury kidney easier in other any position calculus.

Renal calculus is the one of urinary calculus, how to be formed in the summer of sweltering heat, because summer perspires in a large number, even dehydration in body, makes minimizing of urinating, the time be exposed to light summer is in addition long, ultraviolet radiation skin contributes to vitamin D and vitamin A synthesis in body to be increased, and vitamin D and vitamin A can promote intestinal absorption calcium ion, drain calcium and increase in urine, urinary stone material easily produces the nuclei of crystallization, thus forms calculus.Winter weather cold, the hydrouria of people, established microlith is washed away by urine, moves down, and now causes renal colic symptom.So, renal calculus be often " summer formed, winter morbidity ".Renal calculus may long-term existence and asymptomatic, particularly larger calculus.Large compared with little calculus range of activity, when microlith enters UPJ or ureter, cause the wriggling that ureter is violent, to promote that calculus is discharged, so there is angor and hematuria.The pain that renal calculus causes can be divided into dull pain and angor.The history of pain that the patient of 40%-50% has gap to show effect.Pain is often positioned at waist and abdominal part, most in Chen Faxing, also can be constant pain.Some pain only may show as the swollen discomfort of waist acid, and movable or work can impel panic attacks or increase the weight of.Renal colic is serious lancinating pain, often breaks out, and pain is often radiated to inside hypogastric region, groin or stock, and women is then radiated to labia.Renal colic often continues a few hours, also within denumerable minute, both alleviates.When renal colic is serious, pale complexion, whole body is in a cold sweat, thready pulse and fast, even blood pressure drops, in collapse, simultaneously with Nausea and vomiting, abdominal distention constipation.During angor outbreak, hypourocrinia, after angor is alleviated, can have polyuria phenomenon.The common complication of renal calculus is infraction and infects, and many cases are sought medical advice because of urinary tract infection symptom.Infraction then can cause hydronephrosis, occurs epigastrium or waist lump.The main cause that renal calculus is formed is diet, and it is mainly owing to can take in and too much cause by the lithogenous related component of shape in diet: oxalic acid accumulates too much; Purine metabolism is not normal; Fat regimen is too much; Sugar increases; Protein is excessive.

The symptomatic treatment of renal calculus: spasmolytic, pain relieving, fluid infusion, antiinflammatory, treatment by Chinese herbs.The external ripple lithotrity of shaking of main use, PCN gets stone, lithotrity, operative treatment, drug administration calculus etc.Treatment by Chinese herbs is safest in therapeutic modality, and traditional Chinese medical science toxin expelling therapy can change the internal environment of human body, discharges the noxious substance producing calculus in blood, removes the material base that it produces calculus.Comparatively maximum size can make it to dissolve, and fragmentation diminishes and excretes.After purged body endotoxin, owing to having purified organismic internal environment, effectively prevent generation again and the appearance of calculus.

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, Chinese medicine of the treatment renal calculus providing a kind of determined curative effect, toxic and side effects little and preparation method thereof.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of renal calculus, described Chinese medicine comprises following raw medicinal material: Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae, Herba Ephedrae, Herba Rostellulariae, Herba Pentanematis Indici, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba Solani Nigri, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA, Caulis Achnatheri Splendentis, Caulis aristolochiae moupinensis and Medulla Stachyuri (Medulla Helwingiae).

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Corium Erinacei Seu Hemiechianus 10 ~ 20 parts, Radix Granati 15 ~ 25 parts, Bulbus Lilii 5 ~ 20 parts, Folium Rosae Chinensis 10 ~ 25 parts, Flos Eragrostinis cilianensis 10 ~ 25 parts, Folium Vaccinii vitis-idaeae 10 ~ 25 parts, Folium Aeschynomense indicae 15 ~ 30 parts, 10 ~ 25 parts, Herba Ephedrae, Herba Rostellulariae 10 ~ 30 parts, Herba Pentanematis Indici 20 ~ 35 parts, Herba Briggsiae Chienii 15 ~ 25 parts, Herba Lycopodii 10 ~ 20 parts, Herba Damnacanthi 20 ~ 35 parts, Herba Solani Nigri 15 ~ 30 parts, Herba veronicastri villosuli 10 ~ 30 parts, Herba Commelinae 10 ~ 25 parts, DAWANHUA 10 ~ 25 parts, Caulis Achnatheri Splendentis 10 ~ 20 parts, Caulis aristolochiae moupinensis 10 ~ 30 parts and Medulla Stachyuri (Medulla Helwingiae) 10 ~ 30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably:

Corium Erinacei Seu Hemiechianus 10 ~ 15 parts, Radix Granati 20 ~ 25 parts, Bulbus Lilii 15 ~ 20 parts, Folium Rosae Chinensis 15 ~ 25 parts, Flos Eragrostinis cilianensis 15 ~ 25 parts, Folium Vaccinii vitis-idaeae 15 ~ 20 parts, Folium Aeschynomense indicae 20 ~ 25 parts, 15 ~ 20 parts, Herba Ephedrae, Herba Rostellulariae 20 ~ 30 parts, Herba Pentanematis Indici 25 ~ 35 parts, Herba Briggsiae Chienii 15 ~ 20 parts, Herba Lycopodii 10 ~ 15 parts, Herba Damnacanthi 25 ~ 35 parts, Herba Solani Nigri 20 ~ 30 parts, Herba veronicastri villosuli 15 ~ 25 parts, Herba Commelinae 10 ~ 15 parts, DAWANHUA 15 ~ 20 parts, Caulis Achnatheri Splendentis 15 ~ 20 parts, Caulis aristolochiae moupinensis 20 ~ 30 parts and Medulla Stachyuri (Medulla Helwingiae) 15 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Corium Erinacei Seu Hemiechianus 13 parts, Radix Granati 23 parts, Bulbus Lilii 18 parts, Folium Rosae Chinensis 20 parts, Flos Eragrostinis cilianensis 21 parts, Folium Vaccinii vitis-idaeae 18 parts, Folium Aeschynomense indicae 22 parts, 18 parts, Herba Ephedrae, Herba Rostellulariae 25 parts, Herba Pentanematis Indici 26 parts, Herba Briggsiae Chienii 18 parts, Herba Lycopodii 15 parts, Herba Damnacanthi 27 parts, Herba Solani Nigri 25 parts, Herba veronicastri villosuli 23 parts, Herba Commelinae 13 parts, DAWANHUA 18 parts, Caulis Achnatheri Splendentis 16 parts, Caulis aristolochiae moupinensis 25 parts and Medulla Stachyuri (Medulla Helwingiae) 20 parts.

When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae and Herba Ephedrae are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 70 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA and Caulis aristolochiae moupinensis are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 7 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, then adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate mix homogeneously, then load in gelatine capsule.

When the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:

The first step, by Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae and Herba Ephedrae mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,

Second step, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA and Caulis aristolochiae moupinensis are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;

3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.

Beneficial effect of the present invention: Chinese medicine use safety, no pain that renal calculus of the present invention uses, have no side effect, determined curative effect, significantly improve cure rate and total effective rate, and preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of renal calculus, Chinese medicine comprises following raw medicinal material: Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae, Herba Ephedrae, Herba Rostellulariae, Herba Pentanematis Indici, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba Solani Nigri, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA, Caulis Achnatheri Splendentis, Caulis aristolochiae moupinensis and Medulla Stachyuri (Medulla Helwingiae).

The pharmacology of various raw medicinal material is as follows:

Corium Erinacei Seu Hemiechianus: the dry crust of [source] Erinaceidae animal Rrinaceus earopaeus ErinaceuseuropaeusL. or short Rrinaceus earopaeus HemichianusdauricusSundevall.[nature and flavor] bitter, sweet, flat.The pain relieving of [function cures mainly] clots absorbing, hemostasis, controlling nocturnal emission with astringent drugs.For gastralgia, metrorrhagia, has blood in stool, hemorrhoid, seminal emission, the enuresis.[extracts] " national Chinese herbal medicine compilation "

Radix Granati: [source] medical material Ji Yuan: be the root bark of Punicaceae plant Punica granatum L..[nature and flavor] sour in the mouth; Puckery; Warm in nature.[function cures mainly] anthelmintic; Astringing intestine to stop diarrhea; Leukorrhagia stopping.Main ascarid; Cestode; Chronic diarrhea; Chronic dysentery; Leucorrhea with red and white discharge.[extracts] " China's book on Chinese herbal medicine "

Bulbus Lilii: [source] this product is the dry meat scale leaf of liliaceous plant tiger lily, Bulbus Lilii or Lilium tenuifolium.[nature and flavor] are sweet, cold.[return through] GUIXIN, lung meridian.[function cures mainly] nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.[extracts] " Chinese Pharmacopoeia "

Folium Rosae Chinensis: [another name] Chinese rose leaf.[source] medical material Ji Yuan: be the leaf of rosaceous plant Flos Rosae Chinensis.Latin plant animal mineral name: RosachinensisJacq. gathers and stores: the spring to autumn, picking leaves when branch and leaf are luxuriant, using fresh herb or dry.[nature and flavor] micro-hardship; Flat.[return through] Liver Channel.[function cures mainly] promoting blood circulation and detumescence, removing toxic substances, hemostasis.Main sore swollen toxin, scrofula, traumatic injury, waist swelling and pain in knee, traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Flos Eragrostinis cilianensis: [another name] Herba Eragrostidis pilosae, palmate meadowsweet.The herb of [source] grass family Eragrostis plant eragrostis cilianensisLink, Herba Eragrostidis pilosae and Herba Eragrostidis Poaeoidis, its inflorescence is also pharmaceutically acceptable.Autumn in herb summer gathers, and inflorescence was adopted at the florescence, cleans cutting, dries.[nature and flavor] herb: sweet, light, cool.Inflorescence: light is flat.[function cures mainly] herb: wind and heat dispersing, diuresis.For vesical calculus, renal calculus, nephritis, pyelonephritis, cystitis, conjunctivitis, keratitis.Inflorescence: removing toxic substances, antipruritic.For impetigo.[extracts] " national Chinese herbal medicine compilation "

Folium Vaccinii vitis-idaeae: [source] medical material Ji Yuan: be the leaf of ericad Pericarpium Citri tangerinae.[nature and flavor] are bitter; Warm in nature; Mild toxicity.[function cures mainly] detoxifies; Dampness removing.Main stranguria; Gout.[each discussion] 1. " pharmacologys of traditional Chinese medicines ": for drenching toxicity urethritis, cystitis.2. " Chinese Herbal Medicine in Xinjiang handbook ": can diuresis removing toxic substances.[extracts] " China's book on Chinese herbal medicine "

Folium Aeschynomense indicae: [another name] be logical, the wild Medulla Tetrapanacis of stalk, gas Medulla Tetrapanacis, water Medulla Tetrapanacis in vain.[source] is the xylem of leguminous plant Herba Aeschynonenes Indicae stem.Gather and store: the 9-10 month pulls up Herb, removing root, branch and leaf and stem tip portion, peel off peel of stem, get xylem, dry.[nature and flavor] light, micro-hardship; Cool; Flat.[return through] liver; Urinary bladder channel.[function cures mainly] heat clearing away, diuresis, lactogenesis, improving eyesight.Main pyretic stranguria, dysuria, edema, galactostasis, nyctalopia.[extracts] " China's book on Chinese herbal medicine "

Herba Ephedrae: [source] this product is the dry herb stem of Ephedraceae plant plait Herba Ephedrae, epheday intermedia or ephedra equisetina.[nature and flavor] pungent, micro-hardship, temperature.[return through] returns lung, urinary bladder channel.[function cures mainly] diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema; Bronchial asthma.Herba ephedrae nourishing the lung to arrest cough.Be used for table disease to separate, asthma and cough.[extracts] " Chinese Pharmacopoeia "

Herba Rostellulariae: [another name] rank of nobility minister in ancient times, fragrant Soviet Union, industrial occupancy eye one's old mother grass, acute conjunctivitis, little grass, fine dragonfly grass, fly wing, Mus tail are red, watt son grass, five tired grass, hexagonal are celestial, Premna microphylla Turez, Herba hedyotis costatae, fall flowers and plants, Ilex purpurea Hassk.[I.chinensis Sims, yesterday grasshopper lower limb, wild Rohdea japonica Roth, hair Herba Lycopi, bend that glue is young, the wheat head is red, the burnt prunus mume (sieb.) sieb.et zucc. art of mountain Perilla frutescens, false Fructus Capsici, Herba Setariae Viridis, carefully Herba Diclipterae Chinensis, Justicia procumbens linn., six side's infantile malnutrition grass, wheat head Huang, Serpentis eat grass, Phyllostachys congesta Radix Crotalariae szemoensis, cloudy herd-boy, Herba Rostellulariae are careless, Lai Zicao.[source] medical material Ji Yuan: be the herb of acanthaceous plant Herba Rostellulariae.Gather and store: 8-9 month full-bloom stage is gathered, and extracts aerial parts, dries.[nature and flavor] bitter in the mouth; Salty; Pungent; Cold in nature.[return through] returns lung; Liver; Urinary bladder channel.[function cures mainly] heat-clearing and toxic substances removing; Dampness removing removing food stagnancy; Promoting blood circulation and stopping pain.Main cold, fever; Cough; Laryngopharynx swelling and pain; Conjunctival congestion and swelling pain; Infantile malnutrition; Damp-heat dysentery; Malaria; Jaundice; Edema; Stranguria with turbid discharge; Muscle flesh pain; Traumatic injury; Carbuncle furuncle; Eczema.[extracts] " China's book on Chinese herbal medicine "

Herba Pentanematis Indici: [source] medical material Ji Yuan: for feverfew carries on the back the herb of reed millet straw in vain.[nature and flavor] are lightly seasoned; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Relieving stranguria by diuresis.Main Zha rib; Laryngopharynx swelling and pain; Stranguria caused by urinary stone.[each discussion] 1. " Red River Chinese herbal medicine ": heat-clearing and toxic substances removing, relieving stranguria by diuresis.2. " GUIHAIA register ": control infantile malnutrition.[extracts] " China's book on Chinese herbal medicine "

Herba Briggsiae Chienii: [source] medical material Ji Yuan: be root or the herb of Anhui, Gesneriaceae Zhejiang thick cylinder lettuce tongue.[nature and flavor] mildly bitter flavor; Property is put down.[function cures mainly] expelling pathogenic wind from the body surface; To invigorate blood circulation eliminating carbuncle.Main headache due to common cold; Impairment caused by overstrain; Muscles and bones is ached; Carbuncle skin ulcer; Innominate toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Herba Lycopodii: [source] this product is the dry herb of lycopsid Lycopodium clavatum.[nature and flavor] micro-hardship, pungent, temperature.[return through] returns liver,spleen,kidney warp.[function cures mainly] expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.[extracts] " Chinese Pharmacopoeia "

Herba Damnacanthi: [source] Rubiaceae Herba Damnacanthi platymiscium Herba Damnacanthi, is used as medicine with root or Herb.[nature and flavor] are sweet, bitter, flat.[function cures mainly] expelling wind and removing dampness, promoting blood circulation and stopping pain.For hepatitis, bones and muscles pain due to rheumatism, traumatic injury, caries pain.[extracts] " national Chinese herbal medicine compilation "

Herba Solani Nigri: [source] is Solanaceae nightshade Herba Solani Nigri, with all herbal medicine.[nature and flavor] are bitter, cold.Slightly poisonous.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema.For cat fever, toothache, chronic bronchitis, dysentery, urinary system infection, mastitis, leucorrhea, cancer; Carbuncle furuncle furuncle is controlled in external, pemphigus, venom.[extracts] " national Chinese herbal medicine compilation "

Herba veronicastri villosuli: [source] Scrophulariaceae Herba veronicastri villosuli platymiscium Herba veronicastri villosuli, with all herbal medicine.Xia Qiu gathers, and dries.[nature and flavor] are bitter, pungent, cool.Slightly poisonous.[function cures mainly] inducing diuresis to remove edema, dissipating blood stasis detoxifies.For ascites, edema, dysuria, menoxenia, amenorrhea, traumatic injury; Parotitis is controlled in external, furuncle, burn and scald, venom.[extracts] " national Chinese herbal medicine compilation "

Herba Commelinae: [source] this product is the dry aerial parts of Commelianaceae plant Herba Commelinae.[nature and flavor] are sweet, light, cold.[return through] returns lung, stomach, small intestine meridian.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema.For anemopyretic cold, hyperpyrexia, laryngopharynx swelling and pain, edema oliguria, the puckery pain of pyretic stranguria, carbuncle furunculosis.[extracts] " Chinese Pharmacopoeia "

DAWANHUA: [source] is Convolvulaceae calystegia plant DAWANHUA, is used as medicine with root stock and flower.[nature and flavor] are sweet, light, flat.[function cures mainly] root stock: invigorating the spleen and benefiting QI, diuresis, regulating menstruation, leukorrhagia stopping; For insufficiency of the spleen dyspepsia, menoxenia, leucorrhea, milk is rare.Flower: pain relieving; Toothache is controlled in external.[extracts] " national Chinese herbal medicine compilation ".

Caulis Achnatheri Splendentis: [source] medical material Ji Yuan: be the stem of grass Caulis Achnatheri Splendentis, root or seed.[nature and flavor] are sweet; Light; Flat.[function cures mainly] clearing away heat and promoting diuresis.Main urinary tract infection; Urine retention.[each discussion] 1. " Inner Mongol Chinese herbal medicine ": diuresis.Control urinary tract infection, urine retention.2. " soft science in China medicinal plants ": stem: diuresis heat clearing away.Flower: hemostasis.[extracts] " China's book on Chinese herbal medicine "

Caulis aristolochiae moupinensis: [source] Aristolochiaceae birthwort Baoxing horse pocket, is used as medicine with root and stem.[nature and flavor] are bitter, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, row is breast under water, evacuation of pus pain relieving.For dysuria, edema, urinary tract infection, trichomonas vaginitis, rheumatic arthritis, eczema, urticaria, carbuncle.[extracts] " national Chinese herbal medicine compilation "

Medulla Stachyuri (Medulla Helwingiae): [source] Stachyuraceae Stachyurus plant poker tree, Chinese ancient type of banner hoisted on a featherdecked mast joint flower, Yunnan ancient type of banner hoisted on a featherdecked mast joint flower, is used as medicine with stem pith.[nature and flavor] are light, flat.[function cures mainly] clearing away heat and promoting diuresis, lactogenesis.For urinary tract infection, urine retention or oliguria, calentura is thirsty, yellowish or reddish urine, galactostasis.[extracts] " national Chinese herbal medicine compilation "

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Corium Erinacei Seu Hemiechianus 10 ~ 20 parts, Radix Granati 15 ~ 25 parts, Bulbus Lilii 5 ~ 20 parts, Folium Rosae Chinensis 10 ~ 25 parts, Flos Eragrostinis cilianensis 10 ~ 25 parts, Folium Vaccinii vitis-idaeae 10 ~ 25 parts, Folium Aeschynomense indicae 15 ~ 30 parts, 10 ~ 25 parts, Herba Ephedrae, Herba Rostellulariae 10 ~ 30 parts, Herba Pentanematis Indici 20 ~ 35 parts, Herba Briggsiae Chienii 15 ~ 25 parts, Herba Lycopodii 10 ~ 20 parts, Herba Damnacanthi 20 ~ 35 parts, Herba Solani Nigri 15 ~ 30 parts, Herba veronicastri villosuli 10 ~ 30 parts, Herba Commelinae 10 ~ 25 parts, DAWANHUA 10 ~ 25 parts, Caulis Achnatheri Splendentis 10 ~ 20 parts, Caulis aristolochiae moupinensis 10 ~ 30 parts and Medulla Stachyuri (Medulla Helwingiae) 10 ~ 30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Corium Erinacei Seu Hemiechianus 10 ~ 15 parts, Radix Granati 20 ~ 25 parts, Bulbus Lilii 15 ~ 20 parts, Folium Rosae Chinensis 15 ~ 25 parts, Flos Eragrostinis cilianensis 15 ~ 25 parts, Folium Vaccinii vitis-idaeae 15 ~ 20 parts, Folium Aeschynomense indicae 20 ~ 25 parts, 15 ~ 20 parts, Herba Ephedrae, Herba Rostellulariae 20 ~ 30 parts, Herba Pentanematis Indici 25 ~ 35 parts, Herba Briggsiae Chienii 15 ~ 20 parts, Herba Lycopodii 10 ~ 15 parts, Herba Damnacanthi 25 ~ 35 parts, Herba Solani Nigri 20 ~ 30 parts, Herba veronicastri villosuli 15 ~ 25 parts, Herba Commelinae 10 ~ 15 parts, DAWANHUA 15 ~ 20 parts, Caulis Achnatheri Splendentis 15 ~ 20 parts, Caulis aristolochiae moupinensis 20 ~ 30 parts and Medulla Stachyuri (Medulla Helwingiae) 15 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Corium Erinacei Seu Hemiechianus 13 parts, Radix Granati 23 parts, Bulbus Lilii 18 parts, Folium Rosae Chinensis 20 parts, Flos Eragrostinis cilianensis 20 parts, Folium Vaccinii vitis-idaeae 18 parts, Folium Aeschynomense indicae 22 parts, 18 parts, Herba Ephedrae, Herba Rostellulariae 25 parts, Herba Pentanematis Indici 26 parts, Herba Briggsiae Chienii 18 parts, Herba Lycopodii 13 parts, Herba Damnacanthi 27 parts, Herba Solani Nigri 25 parts, Herba veronicastri villosuli 21 parts, Herba Commelinae 13 parts, DAWANHUA 18 parts, Caulis Achnatheri Splendentis 16 parts, Caulis aristolochiae moupinensis 25 parts and Medulla Stachyuri (Medulla Helwingiae) 20 parts.

The present invention further provides again a kind of preparation method of Chinese medicine of above-mentioned treatment renal calculus, and the dosage form of described Chinese medicine is granule, and it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae and Herba Ephedrae are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 70 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA and Caulis aristolochiae moupinensis are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 7 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, then adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate mix homogeneously, then load in gelatine capsule.

When the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:

The first step, by Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae and Herba Ephedrae mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,

Second step, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA and Caulis aristolochiae moupinensis are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;

3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: granule prepared by the present invention

Get Corium Erinacei Seu Hemiechianus 130g, Radix Granati 230g, Bulbus Lilii 180g, Folium Rosae Chinensis 200g, Flos Eragrostinis cilianensis 200g, Folium Vaccinii vitis-idaeae 180g, Folium Aeschynomense indicae 220g, Herba Ephedrae 180g, Herba Rostellulariae 250g, Herba Pentanematis Indici 260g, Herba Briggsiae Chienii 180g, Herba Lycopodii 130g, Herba Damnacanthi 270g, Herba Solani Nigri 250g, Herba veronicastri villosuli 210g, Herba Commelinae 130g, DAWANHUA 180g, Caulis Achnatheri Splendentis 160g, Caulis aristolochiae moupinensis 250g and Medulla Stachyuri (Medulla Helwingiae) 200g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.08, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 83 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.33 times and 0.15 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Embodiment 2: capsule prepared by the present invention

Corium Erinacei Seu Hemiechianus 125g, Radix Granati 225g, Bulbus Lilii 180g, Folium Rosae Chinensis 210g, Flos Eragrostinis cilianensis 210g, Folium Vaccinii vitis-idaeae 190g, Folium Aeschynomense indicae 230g, Herba Ephedrae 190g, Herba Rostellulariae 260g, Herba Pentanematis Indici 270g, Herba Briggsiae Chienii 185g, Herba Lycopodii 135g, Herba Damnacanthi 280g, Herba Solani Nigri 260g, Herba veronicastri villosuli 220g, Herba Commelinae 135g, DAWANHUA 185g, Caulis Achnatheri Splendentis 170g, Caulis aristolochiae moupinensis 260g and Medulla Stachyuri (Medulla Helwingiae) 220g.

Its preparation method comprises the following steps:

The first step, Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae and Herba Ephedrae are mixed in described ratio, add the water extraction volatile oil relative to 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 80 minutes, temperature 45 C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;

Second step, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA and Caulis aristolochiae moupinensis are mixed in described ratio, add relative to mixture 7 times amount determining alcohol be 90% alcohol reflux 4 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 times of water gagings, boil 7 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.29;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 70 DEG C of reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 6 weight portion carboxymethyl starch sodium, 36 weight starch mix homogeneously, then adding 170 weight portion determining alcohols is 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 4.2 weight portion magnesium stearate mix homogeneously, then load in gelatine capsule.

Embodiment 3: syrup prepared by the present invention

Corium Erinacei Seu Hemiechianus 125g, Radix Granati 230g, Bulbus Lilii 185g, Folium Rosae Chinensis 230g, Flos Eragrostinis cilianensis 215g, Folium Vaccinii vitis-idaeae 190g, Folium Aeschynomense indicae 235g, Herba Ephedrae 195g, Herba Rostellulariae 270g, Herba Pentanematis Indici 260g, Herba Briggsiae Chienii 185g, Herba Lycopodii 140g, Herba Damnacanthi 270g, Herba Solani Nigri 265g, Herba veronicastri villosuli 230g, Herba Commelinae 130g, DAWANHUA 190g, Caulis Achnatheri Splendentis 175g, Caulis aristolochiae moupinensis 260g and Medulla Stachyuri (Medulla Helwingiae) 230g.

Its preparation method comprises the following steps:

The first step, Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae and Herba Ephedrae are mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 85%, heating and refluxing extraction 3 times, each reflux, extract, 2 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the medicinal liquid of 1.07, by dry with spray dryer for the concentrated solution after concentrated, be ground into 200 orders subsequently, obtain dry powder;

Second step, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA and Caulis aristolochiae moupinensis being mixed in described ratio, be ground into powder, is that the ethanol of 95% is as solvent with determining alcohol, flood 60 hours, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.26, dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 5 times of second step mixture quality;

3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 6 times amount determining alcohol be 75% alcohol reflux 4 times, each 1.5 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.21, in 65 DEG C of reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 48%, potassium sorbate 0.26%.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20-36g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.62g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.1 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>43.1 crude drug/kg of the present invention, every day, maximum dosage-feeding was 86.2 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.23g crude drug/day/people, adult body weight in 60KG, average dosage is 0.137g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 28g) oral administration gavage Chinese medicine of the present invention is 629 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention presses 13.42,25.12 and 42.26g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: all cases all derive from this Out-patient Department and inpatient, totally 150 examples, be divided into treatment group (75 example) and matched group (75 example) at random.In treatment group 75 example, man 39 example, female 36 example; Age 30-50 year; The course of disease 8 weeks-3 months.In matched group 75 example, man 41 example, female 34 example; Age 30-52 year; The course of disease 6 weeks-3 months.All patients all meet the diagnostic criteria of renal calculus, and with Modern ultrasound technology successively testing result for foundation.Experimental group and matched group be no significant difference (P≤0.01) in age, sex and clinical symptoms.

Diagnostic criteria: with reference to " disease of tcm diagnoses and treatment standard ": waist angina abdominis during (1) outbreak, pain and external genitalia, pale complexion, cold sweat, nausea and vomiting.Can with fever with chills, difficulty and pain in micturition is frequently anxious, or has interruption of urinating.(2) the visible hematuria of naked eyes, or urine has sandstone to discharge.(3) routine urianlysis has erythrocyte.(4) do the ultrasound diagnosis of kidney system or x-ray plain abdominal radiograph, pyelography etc. and can specify stone location.Do cystoscope retrograde urography if desired.

Therapeutic Method:

Treatment group: oral Chinese medicine embodiment 1 granule of the present invention, each 15g, every day 3 times.30 days courses for the treatment of.

Matched group: take clean stone spirit sheet, each 1.5g, every day 3 times.30 days courses for the treatment of.

Meanwhile, two groups of every days keep amount of drinking water 3000-5000ml, rope skipping each 200 times sooner or later.All coordinate the cause of disease, diet and symptomatic treatment.Treat and within first 1 week, stop using that all may affect the relevant medicine of test effect, and in therapeutic process, do not use medicine or the health product of other treatment renal calculus.

Curative effect judging standard: cure: clinical symptom disappearance, B ultrasonic or x-ray abdominal part are taken the photograph sheet inspection display calculus and are disappeared.Effective: clinical symptoms disappears substantially, B ultrasonic or x-ray abdominal part are taken the photograph sheet inspection display calculus quantity and are obviously reduced, and volume obviously reduces, and calculus moves down.(3) effective: clinical symptoms makes moderate progress, B ultrasonic or x-ray abdominal part are taken the photograph sheet inspection display calculus quantity and are reduced, and volume reduces to some extent.(4) invalid: clinical symptoms unchanged or worsen, B ultrasonic or x-ray abdominal part take the photograph sheet inspection display calculus quantity or volume unchanged.

Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result see table 1-1 and table 1-2.As can be seen from table 1-1, adopt treatment by Chinese herbs renal calculus of the present invention, relative to matched group on therapeutic effect, there is significant improvement; As can be seen from table 1-2, adopt treatment by Chinese herbs renal calculus of the present invention, relative to matched group, treatment the course for the treatment of on significantly shorten.

Table 1-1 two groups treats Clinical efficacy comparison after 1 course for the treatment of (unit: example) respectively

Group	Number of cases	Cure	Effective	Effectively	Invalid	Total effective rate
							Treatment group	75	39	26	7	3	72(96％)
Matched group	75	21	23	19	12	63(84％)

After table 1-2 two groups treats 1 course for the treatment of respectively, healing number and time compare (unit: example)

Group	Number of cases	Medication 10 days	Medication 20 days	Medication 30 days
					Treatment group	39	10(13.3％)	25(33.3％)	39(52％)
Matched group	21	6(8％)	14(18.7％)	21(28)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, the advantage of safe without toxic side effect.

Concrete case: patient high certain, man, 29 years old, on January 6th, 2013 came to go to a doctor, on the left of private prosecution, waist abdomen aches more than the moon repeatedly, once violent angor 2 times, pale complexion during outbreak, is in a cold sweat; difficulty and pain in micturition is frequently anxious, and routine urianlysis has erythrocyte, diagnoses and be diagnosed as " two renal calculus through B ultrasonic "The granule of oral administration inventive embodiments 1, each 15g, every day 3 times, take and urinate normal in 4 days, after 10 days, left side waist abdomen pain obviously alleviates, other clinical symptoms disappear substantially, treat after 20 days, clinical symptoms hour, disappear through B ultrasonic image contrast display calculus, cure, follow up a case by regular visits to 3 months without recurrence.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (10)

1. treat the Chinese medicine of renal calculus for one kind, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae, Herba Ephedrae, Herba Rostellulariae, Herba Pentanematis Indici, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba Solani Nigri, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA, Caulis Achnatheri Splendentis, Caulis aristolochiae moupinensis and Medulla Stachyuri (Medulla Helwingiae).

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Corium Erinacei Seu Hemiechianus 10 ~ 20 parts, Radix Granati 15 ~ 25 parts, Bulbus Lilii 5 ~ 20 parts, Folium Rosae Chinensis 10 ~ 25 parts, Flos Eragrostinis cilianensis 10 ~ 25 parts, Folium Vaccinii vitis-idaeae 10 ~ 25 parts, Folium Aeschynomense indicae 15 ~ 30 parts, 10 ~ 25 parts, Herba Ephedrae, Herba Rostellulariae 10 ~ 30 parts, Herba Pentanematis Indici 20 ~ 35 parts, Herba Briggsiae Chienii 15 ~ 25 parts, Herba Lycopodii 10 ~ 20 parts, Herba Damnacanthi 20 ~ 35 parts, Herba Solani Nigri 15 ~ 30 parts, Herba veronicastri villosuli 10 ~ 30 parts, Herba Commelinae 10 ~ 25 parts, DAWANHUA 10 ~ 25 parts, Caulis Achnatheri Splendentis 10 ~ 20 parts, Caulis aristolochiae moupinensis 10 ~ 30 parts and Medulla Stachyuri (Medulla Helwingiae) 10 ~ 30 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Corium Erinacei Seu Hemiechianus 10 ~ 15 parts, Radix Granati 20 ~ 25 parts, Bulbus Lilii 15 ~ 20 parts, Folium Rosae Chinensis 15 ~ 25 parts, Flos Eragrostinis cilianensis 15 ~ 25 parts, Folium Vaccinii vitis-idaeae 15 ~ 20 parts, Folium Aeschynomense indicae 20 ~ 25 parts, 15 ~ 20 parts, Herba Ephedrae, Herba Rostellulariae 20 ~ 30 parts, Herba Pentanematis Indici 25 ~ 35 parts, Herba Briggsiae Chienii 15 ~ 20 parts, Herba Lycopodii 10 ~ 15 parts, Herba Damnacanthi 25 ~ 35 parts, Herba Solani Nigri 20 ~ 30 parts, Herba veronicastri villosuli 15 ~ 25 parts, Herba Commelinae 10 ~ 15 parts, DAWANHUA 15 ~ 20 parts, Caulis Achnatheri Splendentis 15 ~ 20 parts, Caulis aristolochiae moupinensis 20 ~ 30 parts and Medulla Stachyuri (Medulla Helwingiae) 15 ~ 25 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Corium Erinacei Seu Hemiechianus 13 parts, Radix Granati 23 parts, Bulbus Lilii 18 parts, Folium Rosae Chinensis 20 parts, Flos Eragrostinis cilianensis 20 parts, Folium Vaccinii vitis-idaeae 18 parts, Folium Aeschynomense indicae 22 parts, 18 parts, Herba Ephedrae, Herba Rostellulariae 25 parts, Herba Pentanematis Indici 26 parts, Herba Briggsiae Chienii 18 parts, Herba Lycopodii 13 parts, Herba Damnacanthi 27 parts, Herba Solani Nigri 25 parts, Herba veronicastri villosuli 21 parts, Herba Commelinae 13 parts, DAWANHUA 18 parts, Caulis Achnatheri Splendentis 16 parts, Caulis aristolochiae moupinensis 25 parts and Medulla Stachyuri (Medulla Helwingiae) 20 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae and Herba Ephedrae are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 70 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA and Caulis aristolochiae moupinensis are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 7 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, then adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate mix homogeneously, then load in gelatine capsule.

7. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:

The first step, by Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae and Herba Ephedrae mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,

Second step, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA and Caulis aristolochiae moupinensis are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;

3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.

8. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

9. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae and Herba Ephedrae are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 70 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA and Caulis aristolochiae moupinensis are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 7 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, then adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate mix homogeneously, then load in gelatine capsule.

10. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:

The first step, by Corium Erinacei Seu Hemiechianus, Radix Granati, Bulbus Lilii, Folium Rosae Chinensis, Flos Eragrostinis cilianensis, Folium Vaccinii vitis-idaeae, Folium Aeschynomense indicae and Herba Ephedrae mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,

Second step, Herba Briggsiae Chienii, Herba Lycopodii, Herba Damnacanthi, Herba veronicastri villosuli, Herba Commelinae, DAWANHUA and Caulis aristolochiae moupinensis are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;

3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.