CN102743550B - Medicine composition for accelerating healing after fracture surgery, preparation method and application - Google Patents
Medicine composition for accelerating healing after fracture surgery, preparation method and application Download PDFInfo
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Abstract
The invention provides a medicine composition for accelerating healing after a fracture surgery, a preparation method and application. The medicine composition comprises chaff flower root, epimedium herb, walnut kernels, common gendarussa herb, eucommia bark, cistanche, semen psoraleae, caulis spatholobi, pseudo-ginseng, native copper, rhizoma Chuanxiong, motherwort, caulis piperis futokadsurae, radix astragali, Chinese yam, dried orange peel, costus root and acorus gramineus. By the aid of the medicine composition, secretion of growth factors can be promoted, local blood circulation and metabolic level of fracture can be promoted, metabolism is accelerated, and the fracture rapidly heals.
Description
Technical field
The present invention relates to pharmaceutical technology, relate in particular to a kind of be used to accelerating the pharmaceutical composition of healing rate after fracture operation.
Background technology
Fracture is commonly encountered diseases frequently-occurring disease clinically, the local congestive edema of the body that causes after fracture, pain, deformity, moving obstacle etc., had a strong impact on daily life, and after implementing operation or manual reduction treating, in various degree soft tissue injury arranged, suffer from the limb congestive edema and increase the weight of, the pain increased, thereby make fracture healing process become slow.
Union of fracture is one and complicated osteanagenesis repair process, be subject to whole body and local permitted multifactorial impact and adjusting, approximately 5%～10% fracture is due to a variety of causes generation delayed union or disunion, have a strong impact on people's life quality, accelerating union of bone fracture how, improve healing quality is the common problem of paying close attention to of medical circle always.
The Western medicine such as normal abuse of antibiotics, cause the disunion of patient's local infection after fracture operation, new virus, and new pathogenic bacteria is emerged in an endless stream, and has had a strong impact on the treatment of fracture.
From the angle of modern medicine, the process of union of fracture, its essence are exactly that health is transferred all positive factors, participate in the complex process of bone and surrounding tissue injury repairing, show as the motion of damage and anti-damage.Orthopedics and traumatology of Chinese medicine has unique clinical advantage.
Traditional Chinese Medicine thinks that the process of union of fracture is the process of " addiction goes, newborn, bone close ", ancient medicine has discussion more, and the Liu Wansu as far back as Jin Dynasty just has: the novel viewpoint of " damaging a disease, single-minded blood opinion; the lid traumatic injury is flutterred the broken interior damage person of pendant skin, and addiction blood must be arranged ".Because the wound damage must injure muscles and bones, hemorrhage, be condensed into addiction blood, meridians are obstructed, QI and blood must not be declared logical, again because " impairment of QI resulting in pain, injury of configuration resulting in swelling " arranged, " blood addiction alive can not be dispelled; the tired bone of not dispelling can not connect ", " qi being the governor of blood, blood being the material foundation of QI ", " the kidney generating marrow and dominating bone ", " kidney storing essence ".
The treatment by Chinese herbs fracture can promote fracture site bone matrix calcium deposition, can promote the secretion of somatomedin, can promote the local blood circulation of fracturing.Promote the metaboilic level that fracture is local, accelerate metabolism.Make rapid healing of fracture.
Based on this, the invention provides a kind of pharmaceutical composition that can accelerate healing rate after fracture operation.
Summary of the invention
Technical problem to be solved by this invention is, a kind of pharmaceutical composition that can accelerate healing rate after fracture operation is provided, adopt this pharmaceutical composition can promote the secretion of somatomedin, can promote the local blood circulation of fracturing, promote the metaboilic level that fracture is local, accelerate metabolism, make rapid healing of fracture.
In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition that can accelerate healing rate after fracture operation, it comprises: Radix Achyranthis Bidentatae, Herba Epimedii, Semen Juglandis, Herba Gendarussae, the Cortex Eucommiae, Herba Cistanches, Fructus Psoraleae, Caulis Spatholobi, Radix Notoginseng, Pyritum, Rhizoma Chuanxiong, Herba Leonuri, Caulis Piperis Kadsurae, the Radix Astragali, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Rhizoma Acori Graminei.
Wherein, in described pharmaceutical composition, the ratio of weight and number of each component is:
Radix Achyranthis Bidentatae 42～52 weight portions, Herba Epimedii 27～37 weight portions, Semen Juglandis 20～30 weight portions, Herba Gendarussae 25～35 weight portions, the Cortex Eucommiae 19～29 weight portions, Herba Cistanches 37～47 weight portions, Fructus Psoraleae 46～56 weight portions, Caulis Spatholobi 23～33 weight portions, Radix Notoginseng 35～45 weight portions, Pyritum 12～22 weight portions, Rhizoma Chuanxiong 28～38 weight portions, Herba Leonuri 19～29 weight portions, Caulis Piperis Kadsurae 18～28 weight portions, the Radix Astragali 76～86 weight portions, Rhizoma Dioscoreae 62～72 weight portions, Pericarpium Citri Reticulatae 13～23 weight portions, the Radix Aucklandiae 8～18 weight portions, Rhizoma Acori Graminei 5～15 weight portions.
Wherein, in described pharmaceutical composition, the weight fraction ratio of each component is:
Radix Achyranthis Bidentatae 47～52 weight portions, Herba Epimedii 32～37 weight portions, Semen Juglandis 25～30 weight portions, Herba Gendarussae 30～35 weight portions, the Cortex Eucommiae 24～29 weight portions, Herba Cistanches 42～47 weight portions, Fructus Psoraleae 51～56 weight portions, Caulis Spatholobi 28～33 weight portions, Radix Notoginseng 40～45 weight portions, Pyritum 17～22 weight portions, Rhizoma Chuanxiong 33～38 weight portions, Herba Leonuri 24～29 weight portions, Caulis Piperis Kadsurae 23～28 weight portions, the Radix Astragali 81～86 weight portions, Rhizoma Dioscoreae 67～72 weight portions, Pericarpium Citri Reticulatae 18～23 weight portions, the Radix Aucklandiae 13～18 weight portions, Rhizoma Acori Graminei 10～15 weight portions.
Wherein, in described pharmaceutical composition, the weight fraction ratio of each component is:
Radix Achyranthis Bidentatae 47 weight portions, Herba Epimedii 32 weight portions, Semen Juglandis 25 weight portions, Herba Gendarussae 30 weight portions, the Cortex Eucommiae 24 weight portions, Herba Cistanches 42 weight portions, Fructus Psoraleae 51 weight portions, Caulis Spatholobi 28 weight portions, Radix Notoginseng 40 weight portions, Pyritum 17 weight portions, Rhizoma Chuanxiong 33 weight portions, Herba Leonuri 24 weight portions, Caulis Piperis Kadsurae 23 weight portions, the Radix Astragali 81 weight portions, Rhizoma Dioscoreae 67 weight portions, Pericarpium Citri Reticulatae 18 weight portions, the Radix Aucklandiae 13 weight portions, Rhizoma Acori Graminei 10 weight portions.
Wherein, in described Chinese medicine composition, can also further add the Radix Paeoniae Alba, the addition of the described Radix Paeoniae Alba is preferably 10～18 weight portions.
Wherein, in described Chinese medicine composition, can also further add Radix Paeoniae Rubra, the addition of the described Radix Paeoniae Alba is preferably 15～23 weight portions.
The invention provides the preparation method of aforementioned pharmaceutical compositions, it comprises:
The first step, Radix Achyranthis Bidentatae, Herba Epimedii, Semen Juglandis, Herba Gendarussae, the Cortex Eucommiae, Herba Cistanches, Fructus Psoraleae are mixed in proportion, with determining alcohol, be that 70%～80% methanol is as solvent, adopt percolation with the speed of 1～3ml per minute percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into 100 orders～200 purpose powder, the quality of the methanol that adds is 3～5 times of first step mixture quality;
second step, remaining ingredient is mixed in proportion, be ground into powder, add the distilled water with respect to 3～6 times of powder qualities, decocted 2～4 hours, filter, obtain the first filtrate, filtering residue is added to the distilled water with respect to 2～4 times of its quality, decocted 1～2 hour, filter, obtain the second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is 90～95% ethanol, make determining alcohol reach 70%～80%, standing 12～24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into 100 orders～200 purpose powder,
The 3rd step, mix the powder of the first step and second step acquisition, according to needed dosage form, adds conventional auxiliary element, prepares needed pharmaceutical composition.
When the dosage form of described pharmaceutical composition was oral liquid, described the 3rd step was specially:
The powder of the first step and second step acquisition is mixed, add the distilled water with respect to 3～5 times of amounts of powder quality, the sucrose of 0.1～0.3 times, the sodium benzoate of 0.01～0.02 times, stir, and boils, and is cooling, filters packing, the sterilizing oral liquid that namely obtains.
When the dosage form of described pharmaceutical composition was tablet, described the 3rd step was specially:
The powder of the first step and second step acquisition is mixed, with Pulvis Talci, magnesium stearate, mix successively processing, tabletting processing, Cotton seeds, obtain the tablet finished product; The weight ratio of described mixture of powders, Pulvis Talci, magnesium stearate is 100: 1～3: 0.15～0.3.
When the dosage form of described pharmaceutical composition was powder, described the 3rd step was specially:
The powder of the first step and second step acquisition is mixed, with the starch with respect to 1～3 times of mixture quality, mix homogeneously, be prepared into powder.
The present invention also provides a kind of health product that accelerate healing rate after fracture operation, and it comprises above-mentioned pharmaceutical composition.
The present invention also provides the medicine of above-mentioned pharmaceutical composition healing rate after fracture operation is accelerated in preparation or the application in health product.
Beneficial effect of the present invention:
Adopt this pharmaceutical composition can promote the secretion of somatomedin, can promote the local blood circulation of fracturing, promote the metaboilic level that fracture is local, accelerate metabolism, make rapid healing of fracture.
The specific embodiment
according to above-mentioned theory of Chinese medical science, the invention provides the pharmaceutical composition of healing rate after a kind of novel acceleration fracture operation, this pharmaceutical composition comprises Radix Achyranthis Bidentatae, Herba Epimedii, Semen Juglandis, Herba Gendarussae, the Cortex Eucommiae, Herba Cistanches, Fructus Psoraleae, Caulis Spatholobi, Radix Notoginseng, Pyritum, Rhizoma Chuanxiong, Herba Leonuri, Caulis Piperis Kadsurae, the Radix Astragali, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, the Radix Aucklandiae, Rhizoma Acori Graminei, in this pharmaceutical composition, pass through Caulis Spatholobi, Radix Notoginseng, Pyritum, Rhizoma Chuanxiong, Herba Leonuri, Caulis Piperis Kadsurae reaches promoting flow of QI and blood, removing blood stasis and dispelling stagnancy, the effect of righting collateral dredging, pass through Radix Achyranthis Bidentatae, Herba Epimedii, Semen Juglandis, Herba Gendarussae, the Cortex Eucommiae, Herba Cistanches, Fructus Psoraleae is realized nourishing the liver and kidney, to reach the essence and blood abundance, moisten the purpose of nourishing muscle and tendon bone, pass through the Radix Astragali, the Rhizoma Dioscoreae QI invigorating, reaching the gas promoting the circulation of blood also goes, the effect of QI and blood abundance, pass through Pericarpium Citri Reticulatae, the Radix Aucklandiae, Rhizoma Acori Graminei reaches inducing resuscitation and calms the nerves, the function of regulating qi-flowing for strengthening spleen, all medicines share, realize promoting blood circulation and detumescence, dissipating blood stasis, inducing resuscitation is calmed the nerves, pain relieving, circulation of qi promoting continues muscle, the function of symplectic bone.
Wherein, in described pharmaceutical composition, the ratio of weight and number of each component is:
Radix Achyranthis Bidentatae 42～52 weight portions, Herba Epimedii 27～37 weight portions, Semen Juglandis 20～30 weight portions, Herba Gendarussae 25～35 weight portions, the Cortex Eucommiae 19～29 weight portions, Herba Cistanches 37～47 weight portions, Fructus Psoraleae 46～56 weight portions, Caulis Spatholobi 23～33 weight portions, Radix Notoginseng 35～45 weight portions, Pyritum 12～22 weight portions, Rhizoma Chuanxiong 28～38 weight portions, Herba Leonuri 19～29 weight portions, Caulis Piperis Kadsurae 18～28 weight portions, the Radix Astragali 76～86 weight portions, Rhizoma Dioscoreae 62～72 weight portions, Pericarpium Citri Reticulatae 13～23 weight portions, the Radix Aucklandiae 8～18 weight portions, Rhizoma Acori Graminei 5～15 weight portions.
Wherein, in described pharmaceutical composition, the weight fraction ratio of each component is:
Radix Achyranthis Bidentatae 47～52 weight portions, Herba Epimedii 32～37 weight portions, Semen Juglandis 25～30 weight portions, Herba Gendarussae 30～35 weight portions, the Cortex Eucommiae 24～29 weight portions, Herba Cistanches 42～47 weight portions, Fructus Psoraleae 51～56 weight portions, Caulis Spatholobi 28～33 weight portions, Radix Notoginseng 40～45 weight portions, Pyritum 17～22 weight portions, Rhizoma Chuanxiong 33～38 weight portions, Herba Leonuri 24～29 weight portions, Caulis Piperis Kadsurae 23～28 weight portions, the Radix Astragali 81～86 weight portions, Rhizoma Dioscoreae 67～72 weight portions, Pericarpium Citri Reticulatae 18～23 weight portions, the Radix Aucklandiae 13～18 weight portions, Rhizoma Acori Graminei 10～15 weight portions.
Wherein, in described pharmaceutical composition, the weight fraction ratio of each component is:
Radix Achyranthis Bidentatae 47 weight portions, Herba Epimedii 32 weight portions, Semen Juglandis 25 weight portions, Herba Gendarussae 30 weight portions, the Cortex Eucommiae 24 weight portions, Herba Cistanches 42 weight portions, Fructus Psoraleae 51 weight portions, Caulis Spatholobi 28 weight portions, Radix Notoginseng 40 weight portions, Pyritum 17 weight portions, Rhizoma Chuanxiong 33 weight portions, Herba Leonuri 24 weight portions, Caulis Piperis Kadsurae 23 weight portions, the Radix Astragali 81 weight portions, Rhizoma Dioscoreae 67 weight portions, Pericarpium Citri Reticulatae 18 weight portions, the Radix Aucklandiae 13 weight portions, Rhizoma Acori Graminei 10 weight portions.
Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is flat, enters liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite that (blood) is descending, the effect of inducing diuresis for treating stranguria syndrome, treatment soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhea, puerperal abdominal pain due to blood stasis, lump in the abdomen, retention of placenta, pyretic stranguria, stranguria with blood, traumatic injury, carbuncle malignant boil, the cards such as laryngopharynx swelling and pain.
Herba Epimedii: acrid in the mouth, sweet, warm in nature, enter liver, kidney channel, have kidney-replenishing, bone and muscle strengthening, the effect of wind-damp dispelling,, cold extremities with aversion to cold soft for impotence due to deficiency of the kidney, seminal emission premature ejaculation, waist knee joint flaccidity; The cards such as arthralgia due to cold-dampnes or spasm of the limbs are numb, Herba Epimedii is traditional kidney invigorating and YANG supporting Chinese medicine, is rich in flavone compound, has gonadotropic Effect, directly suppresses bone resorption and promoting bone growing, makes organism metabolism be in the positive balance state of bone formation greater than bone resorption.
Semen Juglandis: sweet in the mouth, warm in nature, return kidney channel, lung, large intestine channel, have tonifying the kidney to consolidate the essence, the warming the lung Dingchuan, the effect of intestine moistening, curing mainly suffers from a deficiency of the kidney breathes heavily and coughs, lumbago flaccidity of the lower limbs, sexual impotence, seminal emission, frequent micturition, stranguria caused by urinary stone, the cards such as constipation due to dry stool.
Herba Gendarussae: latin name Gendarussae Herba, acrid in the mouth, hardship, property is flat, returns liver, kidney, lung meridian, has wind-damp dispelling; Dissipating blood stasis blood; The effect of reuniting the fractured tendons and bones, cure mainly rheumatic arthralgia; Menoxenia; Puerperal abdonimal pain; Treating swelling and pain by traumatic injury; The cards such as fracture.
The Cortex Eucommiae: sweet in the mouth, micro-suffering, warm in nature, return liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect, cure mainly deficiency of the liver and kindey, soreness of waist and knee joint, flaccidity and weakness of the lower limbs, the sexual impotence frequent micturition of withering, Liver and kidney weakness, gestation hemorrhage, frequent fetal movement, or habitual abortion, the cards such as hypertension.
Herba Cistanches: sweet in the mouth, one-tenth, warm in nature, enter kidney, large intestine channel, have kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation, for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, the cards such as constipation of deficiency of body fluid after being ill, can strengthen body fluid and cellular immune function, strengthen the mononuclear phagocyte phagocytic activity.
Fructus Psoraleae: latin name Psoraleae Fructus, acrid in the mouth, hardship, warm in nature, enter kidney, spleen channel, kidney invigorating and YANG supporting is arranged, warming spleen and stopping diarrha effect, be mainly used in decline of the fire from the gate of life, the chills and pain of the waist and kness of below element deficiency and cold, frequent urination and enuresis, sexual impotence lingering diarrhea; It is cold that insufficiency of kidney-YANG, spleen soil lose using warming therapy stomachache limb, the cards such as Diarrhoea.
Caulis Spatholobi: bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, blood vessel dilating is arranged, enrich blood and invigorate blood circulation, regulating menstruation, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, have obvious inhibitory action to platelet aggregation, promote animal kidney and the total phosphorus metabolism in uterus, be mainly used in treating the menoxenia that blood deficiency has silt, limbs pain is meciless, the symptoms such as soreness of the waist and knees, pain.
Radix Notoginseng: latin name Notoginseng Radix et Rhizoma, warm in nature, sweet in the mouth, micro-hardship, return liver, stomach warp, have hemostasis, dissipating blood stasis, detumescence, the effect of pain relieving, cure mainly haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, the cards such as carbuncle pain, modern pharmacology proves, Radix Notoginseng has the clotting time of shortening, reduces capillary permeability, improves capillary fragility, promotes bone marrow to manufacture the effects such as platelet, is conducive to hemostasis and shock.
Pyritum: acrid in the mouth, property is flat, has eliminating stasis to stop pain, and the effect of reunion of fractured tendons and bones, cure mainly traumatic injury, the tendon breaking fracture, blood stasis pain, gather, goiter, skin infection, the cards such as scald, " Japan hanako materia medica ": evacuation of pus, repercussive blood, reuniting the fractured tendons and bones, the rear blood heresy of managing property, feel at ease, and spasmolytic is throbbed with fear.With wine mill clothes.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel, have blood-activating and qi-promoting, the effect of wind-expelling pain-stopping, cure mainly menoxenia; The amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; The lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; The cards such as ulcer sores.
Herba Leonuri: latin name Leonuri Herba, bitter in the mouth, suffering, cold nature, enter liver, pericardium channel, has promoting blood flow to regulate menstruation, and the effect of inducing diuresis to remove edema, cure mainly menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria, the cards such as acute nephritis edema.
Caulis Piperis Kadsurae: acrid in the mouth, hardship, slightly warm in nature, return Liver Channel, has wind-damp dispelling, the meridian dredging, the effect of stopping numbness pain, cure mainly anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, the cards such as joint stuffiness.
The Radix Astragali: latin name Astragali Radix, sweet in the mouth, warm in nature, enter spleen, lung meridian, tonification spleen soil is arranged, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effect of holder skin ulcer granulation promoting, cure mainly the weak anorexia and loose stool due to deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.The Radix Astragali strengthens the heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, protect the liver and fall hypoglycemic effect, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had to inhibitory action, but Radix Astragali appreciable impact splenocyte Information Conduction be realized immunoregulation effect.
Rhizoma Dioscoreae: latin name Dioscoreae Rhizoma, sweet in the mouth, property is put down, enter lung, spleen, kidney channel, have strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.
Pericarpium Citri Reticulatae: acrid in the mouth, hardship, warm in nature, return spleen, lung meridian, have regulating qi-flowing for strengthening spleen, the effect of drying dampness to eliminate phlegm, cure mainly stagnation of QI in spleen and stomach, the distension and fullness in the abdomen due to turbid damp obstructing in middle-JIAO, nausea and vomiting, lack of appetite is indigestion and loss of appetite, and cold syndrome of the stomach QI rising in reverse order or stomach have the vomiting of deficiency-heat the card such as to eat less.
The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature, return spleen, stomach, liver, lung meridian, have promoting the circulation of QI to relieve pain, and the effect of strengthening the spleen to promote digestion cures mainly after abdominal distention and pain, dysentery are coerced, played to breast and weighs, and food stagnation does not disappear, the cards such as anorexia.
Rhizoma Acori Graminei: latin name Acori Tatarinowii Rhizoma, acrid in the mouth, hardship, warm in nature, GUIXIN, stomach warp, have the removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, the effect of refreshment Fructus Alpiniae Oxyphyllae, cure mainly the gastral cavity painful abdominal mass not hungry, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dry.Control epilepsy, syncope due to accumulation of phlegm, the calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, the cards such as traumatic injury.
For the heavier patient of pain, can in described Chinese medicine composition, add the Radix Paeoniae Alba, the addition of the described Radix Paeoniae Alba is preferably 10～18 weight portions.
The Radix Paeoniae Alba: bitter in the mouth, acid, cool in nature, return liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, be with inferior card.
For blood deficiency patient more very, can in described Chinese medicine composition, add Radix Paeoniae Rubra, the addition of the described Radix Paeoniae Alba is preferably 15～23 weight portions.
Radix Paeoniae Rubra: bitter in the mouth, cold nature, return Liver Channel, and removing fire from the liver is arranged, clearing away heat and cooling blood, the effect of stasis-dispelling and pain-killing, cure mainly the conjunctival congestion and swelling pain that liver-fire is vigorous, has a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, macule is hemorrhage, and the blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; The caused various pain of blood retardance; The cards such as furuncle carbuncle of heat in blood poison Sheng.
The invention provides the preparation method of aforementioned pharmaceutical compositions, it comprises:
The first step, Radix Achyranthis Bidentatae, Herba Epimedii, Semen Juglandis, Herba Gendarussae, the Cortex Eucommiae, Herba Cistanches, Fructus Psoraleae are mixed in proportion, with determining alcohol, be that 70%～80% methanol is as solvent, adopt percolation with the speed of 1～3ml per minute percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into 100 orders～200 purpose powder, the quality of the methanol that adds is 3～5 times of first step mixture quality;
second step, remaining ingredient is mixed in proportion, be ground into powder, add the distilled water with respect to 3～6 times of powder qualities, decocted 2～4 hours, filter, obtain the first filtrate, filtering residue is added to the distilled water with respect to 2～4 times of its quality, decocted 1～2 hour, filter, obtain the second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is 90～95% ethanol, make determining alcohol reach 70%～80%, standing 12～24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into 100 orders～200 purpose powder,
The 3rd step, mix the powder of the first step and second step acquisition, according to needed dosage form, adds conventional auxiliary element, prepares needed pharmaceutical composition.
Pharmaceutical composition of the present invention preferably is prepared into powder, oral liquid, tablet, capsule.
When the dosage form of described pharmaceutical composition was oral liquid, described the 3rd step was specially:
The powder of the first step and second step acquisition is mixed, add the distilled water with respect to 3～5 times of amounts of powder quality, the sucrose of 0.1～0.3 times, the sodium benzoate of 0.01～0.02 times, stir, and boils, and is cooling, filters packing, the sterilizing oral liquid that namely obtains.
When the dosage form of described pharmaceutical composition was tablet, described the 3rd step was specially:
The powder of the first step and second step acquisition is mixed, with Pulvis Talci, magnesium stearate, mix successively processing, tabletting processing, Cotton seeds, obtain the tablet finished product; The weight ratio of described mixture of powders, Pulvis Talci, magnesium stearate is 100: 1～3: 0.15～0.3.
When the dosage form of described pharmaceutical composition was powder, described the 3rd step was specially:
The powder of the first step and second step acquisition is mixed, with the starch with respect to 1～3 times of mixture quality, mix homogeneously, be prepared into powder.
The present invention also provides a kind of health product that accelerate healing rate after fracture operation, and it comprises above-mentioned pharmaceutical composition.
The present invention also provides the medicine of above-mentioned pharmaceutical composition healing rate after fracture operation is accelerated in preparation or the application in health product.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Powder 1 prepared by embodiment 1 the present invention
by Radix Achyranthis Bidentatae 47g, Herba Epimedii 32g, Semen Juglandis 25g, Herba Gendarussae 30g, Cortex Eucommiae 24g, Herba Cistanches 42g, Fructus Psoraleae 51g mixes, with determining alcohol be 80% methanol 1000g as solvent, adopt percolation with the speed of 2ml per minute percolation slowly, collect percolate, concentrating under reduced pressure drying, obtain and get dry extract, and is ground into 100 purpose powder, by Caulis Spatholobi 28g, Radix Notoginseng 40g, Pyritum 17g, Rhizoma Chuanxiong 33g, Herba Leonuri 24g, Caulis Piperis Kadsurae 23g, Radix Astragali 81g, Rhizoma Dioscoreae 67g, Pericarpium Citri Reticulatae 18g, Radix Aucklandiae 13g, Rhizoma Acori Graminei 10g mixes, and is ground into powder, adds the distilled water of 1500g, decocted 3 hours, and filtered, obtain the first filtrate, the distilled water that filtering residue is added to 300g, decocted 2 hours, filters, obtain the second filtrate, merge filtrate, concentrate away the water of 3/4 volume, adding determining alcohol is 95% ethanol, make determining alcohol reach 70%, standing 12 hours, filter concentrating under reduced pressure, dry, obtain and get dry extract, be ground into 100 purpose powder, the powder that obtains is previously mixed, with the starch of 1200g, mix homogeneously, be prepared into powder 1.
Acute toxicity test
Powder 1 with the present embodiment 1 preparation, be dissolved in distilled water, with 200 times of clinical consumption per day, gives white mice feeding dispensing, observed 5.All white mice are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.
Long term toxicity test
By 1 pair of mice of powder of embodiment 1 preparation by 7.81,18.34 and 40.11g crude drug/kg be dissolved in water, 12 weeks of continuous use, every day 2 times, and after 3 weeks of drug withdrawal, result shows: Chinese medicine of the present invention all has no significant effect indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, the internal organs naked eyes do not find that difference changes and the histological examination result shows, after 12 weeks of medication and 3 weeks of drug withdrawal, each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after Chinese medicine of the present invention is to the rat long-term prescription, after drug withdrawal, also there is no the difference reaction, application safety.
Powder 2 prepared by embodiment 2 the present invention
by Radix Achyranthis Bidentatae 50g, Herba Epimedii 34g, Semen Juglandis 28g, Herba Gendarussae 32g, Cortex Eucommiae 27g, Herba Cistanches 46g, Fructus Psoraleae 56g mixes, with determining alcohol be 80% methanol 1000g as solvent, adopt percolation with the speed of 2ml per minute percolation slowly, collect percolate, concentrating under reduced pressure drying, obtain and get dry extract, and is ground into 100 purpose powder, by Caulis Spatholobi 30g, Radix Notoginseng 41g, Pyritum 18g, Rhizoma Chuanxiong 36g, Herba Leonuri 25g, Caulis Piperis Kadsurae 26g, Radix Astragali 84g, Rhizoma Dioscoreae 69g, Pericarpium Citri Reticulatae 19g, Radix Aucklandiae 13g, Rhizoma Acori Graminei 12g mixes, and is ground into powder, adds the distilled water of 1500g, decocted 3 hours, and filtered, obtain the first filtrate, the distilled water that filtering residue is added to 300g, decocted 2 hours, filters, obtain the second filtrate, merge filtrate, concentrate away the water of 3/4 volume, adding determining alcohol is 95% ethanol, make determining alcohol reach 70%, standing 12 hours, filter concentrating under reduced pressure, dry, obtain and get dry extract, be ground into 100 purpose powder, the powder that obtains is previously mixed, with the starch of 1200g, mix homogeneously, be prepared into powder 2.
Oral liquid prepared by embodiment 3 the present invention
by Radix Achyranthis Bidentatae 47g, Herba Epimedii 32g, Semen Juglandis 25g, Herba Gendarussae 30g, Cortex Eucommiae 24g, Herba Cistanches 42g, Fructus Psoraleae 51g mixes, with determining alcohol be 80% methanol 1000g as solvent, adopt percolation with the speed of 2ml per minute percolation slowly, collect percolate, concentrating under reduced pressure drying, obtain and get dry extract, and is ground into 100 purpose powder, by Caulis Spatholobi 28g, Radix Notoginseng 40g, Pyritum 17g, Rhizoma Chuanxiong 33g, Herba Leonuri 24g, Caulis Piperis Kadsurae 23g, Radix Astragali 81g, Rhizoma Dioscoreae 67g, Pericarpium Citri Reticulatae 18g, Radix Aucklandiae 13g, Rhizoma Acori Graminei 10g mixes, and is ground into powder, adds the distilled water of 1500g, decocted 3 hours, and filtered, obtain the first filtrate, the distilled water that filtering residue is added to 300g, decocted 2 hours, filters, obtain the second filtrate, merge filtrate, concentrate away the water of 3/4 volume, adding determining alcohol is 95% ethanol, makes determining alcohol reach 70%, standing 12 hours, filter concentrating under reduced pressure, drying, obtain and get dry extract, be ground into 100 purpose powder, the powder that obtains is previously mixed, the distilled water that adds 2400g, the sucrose of 60g, the sodium benzoate of 7g, stir, boil, cooling, filter packing, the sterilizing oral liquid that namely obtains.
Tablet prepared by embodiment 4 the present invention
by Radix Achyranthis Bidentatae 48g, Herba Epimedii 36g, Semen Juglandis 29g, Herba Gendarussae 30g, Cortex Eucommiae 25g, Herba Cistanches 44g, Fructus Psoraleae 53g mixes, with determining alcohol be 80% methanol 1000g as solvent, adopt percolation with the speed of 2ml per minute percolation slowly, collect percolate, concentrating under reduced pressure drying, obtain and get dry extract, and is ground into 100 purpose powder, by Caulis Spatholobi 29g, Radix Notoginseng 42g, Pyritum 17g, Rhizoma Chuanxiong 34g, Herba Leonuri 27g, Caulis Piperis Kadsurae 24g, Radix Astragali 83g, Rhizoma Dioscoreae 70g, Pericarpium Citri Reticulatae 19g, Radix Aucklandiae 14g, Rhizoma Acori Graminei 11g mixes, and is ground into powder, adds the distilled water of 1500g, decocts 3 hours, filter, obtain the first filtrate, filtering residue is added to the distilled water of 300g, decocted 2 hours, filter, obtain the second filtrate, merge filtrate, concentrate away the water of 3/4 volume, adding determining alcohol is 95% ethanol, makes determining alcohol reach 70%, standing 12 hours, filters, concentrating under reduced pressure, drying, obtain and get dry extract, be ground into 100 purpose powder, the powder that obtains previously mixed, with the 70g Pulvis Talci, 1.3g magnesium stearate mixes processing successively, tabletting is processed, Cotton seeds, obtain tablet.
Embodiment 5 clinical experiments
Clinical data
Choose in February, 2008～2012 patient's 163 examples in year January, male's 92 examples, women's 71 examples; 27～55 years old age, average 39.2 years old; The course of disease 5～8 months, average 6 months; Traffic accident injury 57 examples, crush injury 41 examples, traumatic injury 65 examples; Tibial shaft 37 examples, femoral shaft 29 examples, lesion of lower segment of humerus 41 examples, ulna 19 examples, radius 37 examples.Before above-mentioned case received treatment of Chinese herbs, take the photograph sheet and show that the fracture end para-position is good to line, all have in steel plate screw or interlocking intramedullary nail fixing, the inside-fixture Non Apparent Abnormality, fracture line is clear, and without growth of spur, above-mentioned patient is divided into two groups immediately, treatment group 93 examples, matched group 70 examples, 2 groups of patients are all without other serious organic disease, and condition is basically identical.
Diagnosis and inclusive criteria
(1) surpass the general healing time of similar fracture, common healing time is with reference to " practical orthopaedics "; (2) meet the characteristics of above-mentioned fracture delayed union; (3) the voluntary received treatment of Chinese herbs of patient.
Therapeutic Method
Treatment group is taken the powder 1 of the embodiment of the present invention 1 preparation in the conventional therapies such as fixing, traction, every day 3 times, each 200g, with after water dissolution, taking, matched group is taken Western medicine in the conventional therapies such as fixing, traction: 5 piece/timess of compound recipe chrondroitin sheets, days 3 times.Equal 1 week is 1 course for the treatment of, is used in conjunction 9 courses for the treatment of, after 3 courses for the treatment of, adds up curative effect.Remove the unfavorable factor of union of fracture, as infected, the exercise of mistake, stress interference etc.Strengthen favourable union of fracture factor, suitable outer fixing under, carry out suitable functional exercise, to increase local blood circulation, and utilize the contractility of muscle on the limbs longitudinal axis, two fracture ends are combined closely etc.
Criterion of therapeutical effect
The bony union standard: local standard be local without extremely movable,
Without tenderness and vertical percussion pain.The iconography standard is that X-ray film shows moderate to a large amount of growth of spur, and fracture line is fuzzy, has the seriality callus to pass through fracture line.Profile is that lower limb are not held up and turned, the continuous walking 3min on level land, and be no less than 30 steps; The all fractures of Continuous Observation 2 are indeformable.Take a turn for the better: local tenderness and vertically to kowtow alleviation of pain light; X-ray is shown with moderate or a small amount of growth of spur, and the fuzzyyer and fracture end of fracture line is without hardening phenomenon.Invalid: clinical symptoms is without alleviating, and x-ray shows that fracture line is without improvement or to the disunion phase.
Result
Treatment group 93 examples, treat to clinical union of bone from accepting this group, 3 courses for the treatment of of shortest time, the longest 8 courses for the treatment of, average 5 courses for the treatment of, the whole bony unions for the treatment of group, total effective rate 100%, matched group 70 examples, 4 courses for the treatment of of shortest time, the longest 9 courses for the treatment of, bony union 47 examples wherein, 17 examples that take a turn for the better, invalid 6 examples, total effective rate 91.42%.
Model case
Lee, cause the multiple fracture to phalanges 32 places from scapula because getting into an accident, other comprises the regular and irregular fracture of humerus.By surperficial excoriation, dispose, sterilization, from the humerus to the clavicle and other fracture clamping plate that reset one by one fix, on the basis of the conventional therapies such as fixing, traction, take the powder 2 of the embodiment of the present invention 2 preparations, every day 3 times, each 300g, after 10 days, fall crust, all healed after January, do not stay cicatrix, with by X-ray, look into all positions still can, or pairs of bit line is good etc.Recovered normal on the 45th.
This intellectual property of primary enforcement that all are above-mentioned, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away from, to any simple modification, equivalent variations and remodeling that above embodiment does, still belong to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (5)
1. pharmaceutical composition that accelerates healing rate after fracture operation, it is characterized in that: in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is, Radix Achyranthis Bidentatae 42～52 weight portions, Herba Epimedii 27～37 weight portions, Semen Juglandis 20～30 weight portions, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 25～35 weight portions, the Cortex Eucommiae 19～29 weight portions, Herba Cistanches 37～47 weight portions, Fructus Psoraleae 46～56 weight portions, Caulis Spatholobi 23～33 weight portions, Radix Notoginseng 35～45 weight portions, Pyritum 12～22 weight portions, Rhizoma Chuanxiong 28～38 weight portions, Herba Leonuri 19～29 weight portions, Caulis Piperis Kadsurae 18～28 weight portions, the Radix Astragali 76～86 weight portions, Rhizoma Dioscoreae 62～72 weight portions, Pericarpium Citri Reticulatae 13～23 weight portions, the Radix Aucklandiae 8～18 weight portions, Rhizoma Acori Graminei 5～15 weight portions.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that: in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is, Radix Achyranthis Bidentatae 47～52 weight portions, Herba Epimedii 32～37 weight portions, Semen Juglandis 25～30 weight portions, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30～35 weight portions, the Cortex Eucommiae 24～29 weight portions, Herba Cistanches 42～47 weight portions, Fructus Psoraleae 51～56 weight portions, Caulis Spatholobi 28～33 weight portions, Radix Notoginseng 40～45 weight portions, Pyritum 17～22 weight portions, Rhizoma Chuanxiong 33～38 weight portions, Herba Leonuri 24～29 weight portions, Caulis Piperis Kadsurae 23～28 weight portions, the Radix Astragali 81～86 weight portions, Rhizoma Dioscoreae 67～72 weight portions, Pericarpium Citri Reticulatae 18～23 weight portions, the Radix Aucklandiae 13～18 weight portions, Rhizoma Acori Graminei 10～15 weight portions.
3. pharmaceutical composition as claimed in claim 1, it is characterized in that: in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is, Radix Achyranthis Bidentatae 47 weight portions, Herba Epimedii 32 weight portions, Semen Juglandis 25 weight portions, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30 weight portions, the Cortex Eucommiae 24 weight portions, Herba Cistanches 42 weight portions, Fructus Psoraleae 51 weight portions, Caulis Spatholobi 28 weight portions, Radix Notoginseng 40 weight portions, Pyritum 17 weight portions, Rhizoma Chuanxiong 33 weight portions, Herba Leonuri 24 weight portions, Caulis Piperis Kadsurae 23 weight portions, the Radix Astragali 81 weight portions, Rhizoma Dioscoreae 67 weight portions, Pericarpium Citri Reticulatae 18 weight portions, the Radix Aucklandiae 13 weight portions, Rhizoma Acori Graminei 10 weight portions.
4. as the preparation method of the described pharmaceutical composition of claims 1 to 3 any one, it is characterized in that, comprising:
The first step, Radix Achyranthis Bidentatae, Herba Epimedii, Semen Juglandis, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris), the Cortex Eucommiae, Herba Cistanches, Fructus Psoraleae are mixed in proportion, with determining alcohol, be that 70%～80% methanol is as solvent, adopt percolation with the speed of 1～3ml per minute percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into 100 orders～200 purpose powder, the quality of the methanol that adds is 3～5 times of first step mixture quality;
second step, the surplus stock medical material is mixed in proportion, be ground into powder, add the distilled water with respect to 3～6 times of powder qualities, decocted 2～4 hours, filter, obtain the first filtrate, filtering residue is added to the distilled water with respect to 2～4 times of its quality, decocted 1～2 hour, filter, obtain the second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is 90～95% ethanol, make determining alcohol reach 70%～80%, standing 12～24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into 100 orders～200 purpose powder,
The 3rd step, mix the powder of the first step and second step acquisition, according to needed dosage form, adds conventional auxiliary element, prepares needed pharmaceutical composition.
5. the preparation method of pharmaceutical composition as claimed in claim 4, is characterized in that, comprising:
When the dosage form of described pharmaceutical composition was oral liquid, described the 3rd step was specially:
The powder of the first step and second step acquisition is mixed, add the distilled water with respect to 3～5 times of amounts of powder quality, the sucrose of 0.1～0.3 times, the sodium benzoate of 0.01～0.02 times, stir, and boils, and is cooling, filters packing, the sterilizing oral liquid that namely obtains;
When the dosage form of described pharmaceutical composition was tablet, described the 3rd step was specially:
The powder of the first step and second step acquisition is mixed, with Pulvis Talci, magnesium stearate, mix successively processing, tabletting processing, Cotton seeds, obtain the tablet finished product; The weight ratio of described mixture of powders, Pulvis Talci, magnesium stearate is 100: 1～3: 0.15～0.3;
When the dosage form of described pharmaceutical composition was powder, described the 3rd step was specially:
The powder of the first step and second step acquisition is mixed, with the starch with respect to 1～3 times of mixture quality, mix homogeneously, be prepared into powder.
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| CN101361872A (en) * | 2008-09-28 | 2009-02-11 | 庄仲 | Traditional Chinese medicine for quickly treating bone fracture and postoperative nonunion and delayed healing |
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