CN110882346A

CN110882346A - Tibetan medicine medicament and preparation method thereof

Info

Publication number: CN110882346A
Application number: CN201911421181.4A
Authority: CN
Inventors: 西洛次仁; 洛吉
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-12-31
Filing date: 2019-12-31
Publication date: 2020-03-17

Abstract

A Tibetan medicament and a preparation method thereof, belonging to the technical field of traditional Chinese medicine medicaments. The feed comprises the following raw materials in parts by weight: 8-12 parts of lilium caput-jobi, 21-29 parts of drynaria fortunei, 26-34 parts of filifolium filiformis, 21-29 parts of rhododendron, 26-34 parts of sinopodophyllum hexandrum and 1-15 parts of honey. The preparation method of the Tibetan medicine medicament comprises the following steps: 1) respectively drying the lilium brownii, the drynaria sinense, the filifolium filiformis, the rhododendron and the sinopodium hexandrum, and then weighing according to the parts by weight; 2) pulverizing the dried lily bulb, drynaria chinensis, chrysanthemum tenuifolium, azalea and sinopodophyllum hexandrum, adding 65-95% ethanol solution by volume percent for reflux extraction, filtering to obtain filtrate, concentrating and drying the filtrate to obtain extract, adding honey, and stirring uniformly to obtain the traditional Chinese medicine composition. The Tibetan medicine medicament can effectively treat sunburn, chloasma and acne.

Description

Tibetan medicine medicament and preparation method thereof

Technical Field

A Tibetan medicament and a preparation method thereof, belonging to the technical field of traditional Chinese medicine medicaments.

Background

The pigmented spots are spots of different colors from the surrounding spots and are pigmentary disorder dermatosis. A common skin disease with brown or melanotic and damaged face due to the increase of skin melanin is frequently generated at cheek and forehead parts and aggravates after being exposed to the sun; sunburn and chloasma belong to the colored patches. Acne is a chronic inflammatory skin disease of a pilosebaceous unit, mainly occurs to teenagers, has great influence on the psychology and the social interaction of the teenagers, but can be naturally relieved or healed after adolescence; the clinical manifestations are marked by the polymorphic skin lesions of face, such as acne, papule, pustule, and nodule.

The existing medicament for treating sunburn, chloasma and acne usually takes effect slowly, has undesirable curative effect, and has low cure rate and low effective rate on sunburn and chloasma.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: overcomes the defects of the prior art, and provides a Tibetan medicine medicament and a preparation method thereof, and the Tibetan medicine medicament can effectively treat sunburn, chloasma and acne.

The technical scheme adopted by the invention for solving the technical problems is as follows: the Tibetan medicine medicament comprises the following raw materials in parts by weight: 8-12 parts of lilium caput-jobi, 21-29 parts of drynaria fortunei, 26-34 parts of filifolium filiformis, 21-29 parts of rhododendron, 26-34 parts of sinopodophyllum hexandrum and 1-15 parts of honey.

Preferably, the Tibetan medicine medicament comprises the following raw materials in parts by weight: 9-11 parts of lilium caput-medusae, 23-27 parts of drynaria fortunei, 28-32 parts of filifolium filiformis, 23-27 parts of rhododendron, 28-32 parts of sinopodophyllum hexandrum and 2-10 parts of honey.

Preferably, the Tibetan medicine medicament comprises the following raw materials in parts by weight: 10 parts of lily, 25 parts of drynaria fortunei, 30 parts of chrysanthemum tenuifolium, 25 parts of azalea, 30 parts of podophyllum hexandrum and 3-6 parts of honey.

Preferably, the Tibetan medicine medicament also comprises the following raw materials in parts by weight: 300-400 parts of groundsel. Preferably, the groundsel is 310-350 parts.

The extraction method of the groundsel comprises the following steps: extracting volatile oil of herba Senecionis Scandentis by water distillation.

The groundsel is at least one of groundsel, groundsel and groundsel.

Preferably, the groundsel is prepared by mixing the groundsel with a mass ratio of 2-3: 1 and mixing to obtain the product.

The honey is China native honey or discharged honey.

The preparation method of the Tibetan medicine medicament comprises the following steps:

1) respectively drying the lilium brownii, the drynaria sinense, the filifolium filiformis, the rhododendron and the sinopodium hexandrum, and then weighing according to the parts by weight;

2) pulverizing the dried lily bulb, drynaria chinensis, chrysanthemum tenuifolium, azalea and sinopodophyllum hexandrum, adding 65-95% ethanol solution by volume percent for reflux extraction, filtering to obtain filtrate, concentrating and drying the filtrate to obtain extract, adding honey, and stirring uniformly to obtain the traditional Chinese medicine composition.

Groundsel, a kind of Compositae, belongs to the genus groundsel, and originates from grass slopes, forest edges and creeks with elevation of 2600-3500 m. The pharmacological action is as follows: has antibacterial, hepatoprotective, anticancer, antioxidant, and free radical scavenging effects. The property and taste effects are as follows: climbing groundsel herb: bitter taste and cool nature. Clearing away heat and toxic material, setting bone and healing wound. It can be used for treating sore, liver heat, gallbladder heat, toxic heat, fracture, wound, and pyocutaneous disease. It is used externally to treat skin ulcer, furuncle, neurodermatitis, infantile eczema, fracture, and traumatic injury; it can be used for treating rheumatic arthritis, chronic lumbago, leg pain, sprain, blood stasis, edema, and puerperal hemorrhage.

Climbing groundsel herb is perennial herb of groundsel of Compositae. Baibei Qianlui, bitter in taste and cool in nature. Clearing away heat and toxic material, setting bone and healing wound. Has antibacterial, hepatoprotective, anticancer, antioxidant, antiulcer, and free radical scavenging effects. It can be used for treating sore, liver heat, gallbladder heat, toxic heat, fracture, wound, and pyocutaneous disease. Or decocting the aerial parts to obtain a paste. It can be used for treating skin ulcer, furuncle, neurodermatitis, infantile eczema, fracture, and traumatic injury. Pharmacological research in recent years shows that groundsel has the effects of diuresis, tumor resistance, virus resistance, bacteria resistance, oxidation resistance and the like.

Lilium Brownii is flower of Lilium Brownii of Lilium. Growing in the stone gaps of the miscellaneous tree forest land at the altitude of 2100-4000 m. The property and taste effects are as follows: sweet taste and cool nature. Moistening lung for arresting cough, clearing heat away, tranquilizing mind, promoting urination, setting bone, and healing wound. Can be used for treating tuberculosis, hemoptysis, vexation, palpitation, mental uneasiness, edema, difficulty in micturition, fracture, and wound. Has the effects of treating cough due to lung diseases and nourishing body. Has tranquilizing, antiallergic, antifatigue, and anoxia resisting effects.

Rhizome of Chinese drynaria rhizome, drynaria fortunei, drynaria of family drynariaceae. It is grown on stone or tree in mountain area. Distributed in Qinghai, Gansu, Shaanxi, Sichuan, Yunnan, etc. Mainly treats toxic heat, botulism, trauma and kidney heat.

Filifolium sibiricum is a whole plant of Asteraceae subfamily. Gansu middle, Sichuan northwest, Tibet east and Qinghai. The plant grows on hilly grassland and has an altitude of 2000-4580 meters. Distribution is also found in northwest india. The Tibetan medicine has the efficacy of treating carbuncle and furuncle, nephropathy and lung disease. Treating laryngopharyngeal diseases, anthrax, diseases, ulcer, furuncle, pulmonary diseases, and nephropathy. The pharmacological action is as follows: 1. dispel phlegm and relieve dyspnea. 2, antibacterial and anti-inflammatory effects. 3, it has the functions of improving anoxia endurance and preventing pulmonary edema. The property and taste effects are as follows: bitter taste, warm and mild nature. Stop bleeding, resolve swelling of limbs. It can be used for treating swelling and cold type tumor, especially sore and nephropathy.

Rhododendron, also called rhododendron molle and rhododendron simsii, is a flower of Rhododendron in Ericaceae. The azalea is red flower, white flower is not selected, because the white flower has poison. The pharmacological action is as follows: has antitussive, expectorant, and antitumor effects. The property and taste effects are as follows: bitter taste and mild nature. Promoting pus discharge, stopping bleeding, regulating menstruation, relieving cough, and relieving asthma. Treating syphilitic inflammation, lung abscess, visceral abscess, tracheitis, etc.; it is used externally to treat skin itching.

Podophyllum hexandrum, the whole dry fruit of Podophyllum hexandrum of Podophyllum. And (4) fruit: sweet taste, mild nature and no toxicity. Regulate menstruation and blood, and lead dead fetus. It can be used for treating female blood stasis, placenta hominis, amenorrhea, and lumbago, and can prevent miscarriage. Root and rhizome: bitter and slightly pungent in flavor, mild in nature and slightly toxic. Regulating blood, stopping bleeding, removing toxic substance, and relieving swelling. It can be used for treating lumbago, skelalgia, cough, asthma, edema, dermatoses, cardialgia, gastralgia, and traumatic injury.

Honey, sweet and neutral. Meridian tropism enters lung, spleen and large intestine meridians. The functions are mainly tonifying middle-jiao, moistening dryness, relieving pain and detoxifying. Can be used for treating abdominal pain, dry cough due to lung dryness, and constipation due to intestinal dryness; it is indicated for sores and ulcers, scald due to hot water or fire. The Mel is all flowers Mel or single flower Mel. The uniflower honey is any one of shrub honey, date honey, linden honey, longan honey and litchi honey. The Chinese native honey is produced by Chinese bee. The discharged honey is honey produced by the discharged bees. Preferably, the honey is all-flower honey produced by wild ganoderma bees, is collected from flowers of various wild plants in the local ganoderma, is collected once a year, has high content of active ingredients, has good detoxifying and pain relieving effects, and has a good treatment effect on acne.

The application of the Tibetan medicine medicament of the invention is as follows: the application in preparing medicine for treating sunburn, chloasma and acne is provided. The Tibetan medicine preparation is an external preparation and can be prepared into tinctures, creams and wet dressings.

Compared with the prior art, the Tibetan medicament and the preparation method thereof have the beneficial effects that:

1. the Tibetan medicine medicament can effectively treat sunburn and chloasma. The Tibetan medicine preparation prepared from 8-12 parts of lilium caput-brownii, 21-29 parts of drynaria chinensis, 26-34 parts of filifolium filiformis, 21-29 parts of rhododendron, 26-34 parts of sinopodophyllum hexandrum and 1-15 parts of honey has a good freckle removing effect and can effectively treat sunburn and chloasma. The combination of the lilium brownii, the drynaria fortunei, the filifolium floridii, the rhododendron and the sinopodophyllum hexandrum has high antioxidant effect and can effectively lighten formed color spots. The groundsel herb volatile oil has the effect of reducing glutamic-pyruvic transaminase of the liver, can effectively fade chloasma, and has obviously improved effect of treating sunburn and chloasma after the groundsel herb volatile oil is added.

2. The Tibetan medicine medicament can effectively treat acne. The lilium caput-medusae, the drynaria sinense and the filifolium floridii have high antibacterial effect and can effectively inhibit the proliferation of acne bacillus. The groundsel herb volatile oil has antibacterial and antiviral effects and can effectively treat acne. The volatile oil has stronger antibacterial activity and better treatment effect on acne by combining senecio scandens and senecio baibei.

Detailed Description

Examples 1 to 6 are specific examples of a Tibetan medicine and a method for producing the same according to the present invention, and examples 1 and 6 are the best modes of practice. The honey is Baihua brand Baihua honey.

Example 1

The feed is prepared from the following raw materials in parts by weight: 10 parts of lilium brownii, 25 parts of drynaria fortunei, 30 parts of chrysanthemum tenuifolium, 25 parts of azalea, 30 parts of podophyllum hexandrum and 5 parts of honey;

the preparation method comprises the following steps:

1) respectively drying the lilium caput-medusae, the drynaria sinense, the filifolium filiformis, the rhododendron simsii and the sinopodium hexandrum at 50 ℃, and then weighing in parts by weight;

2) pulverizing dried Bulbus Lilii, rhizoma Drynariae, flos Matricariae Chamomillae, flos Rhododendri Simsii and radix Podophylli, adding 70 vol% ethanol solution, heating and reflux extracting, filtering to obtain filtrate, concentrating the filtrate, drying to obtain extract, adding Mel, and stirring.

Example 2

The feed is prepared from the following raw materials in parts by weight: 11 parts of lilium brownie, 23 parts of drynaria fortunei, 32 parts of chrysanthemum tenuifolium, 23 parts of azalea, 32 parts of sinopodophyllum hexandrum and 2 parts of honey;

the preparation method comprises the following steps:

2) pulverizing dried Bulbus Lilii, herba Dendrobii, flos Matricariae Chamomillae, flos Rhododendri Simsii and radix Podophylli, adding 80 vol% ethanol solution, heating and reflux-extracting, filtering to obtain filtrate, concentrating the filtrate, drying to obtain extract, adding Mel, and stirring.

Example 3

The feed is prepared from the following raw materials in parts by weight: 9 parts of lilium caput-medusae, 27 parts of drynaria fortunei, 28 parts of chrysanthemum tenuifolius, 27 parts of azalea, 28 parts of sinopodium hexandrum and 10 parts of honey;

the preparation method comprises the following steps:

2) pulverizing dried Bulbus Lilii, herba Dendrobii, flos Matricariae Chamomillae, flos Rhododendri Simsii and radix Podophylli, adding 95 vol% ethanol solution, heating and reflux-extracting, filtering to obtain filtrate, concentrating the filtrate, drying to obtain extract, adding Mel, and stirring.

Example 4

The feed is prepared from the following raw materials in parts by weight: 12 parts of lilium brownie, 21 parts of drynaria fortunei, 34 parts of chrysanthemum tenuifolium, 21 parts of azalea, 34 parts of podophyllum hexandrum and 1 part of honey;

the preparation method comprises the following steps:

Example 5

The feed is prepared from the following raw materials in parts by weight: 8 parts of lilium brownii, 29 parts of drynaria fortunei, 26 parts of chrysanthemum tenuifolium, 29 parts of azalea, 26 parts of podophyllum hexandrum and 15 parts of honey;

the preparation method comprises the following steps:

2) pulverizing dried Bulbus Lilii, herba Dendrobii, flos Matricariae Chamomillae, flos Rhododendri Simsii and radix Podophylli, adding 65 vol% ethanol solution, heating and reflux-extracting, filtering to obtain filtrate, concentrating the filtrate, drying to obtain extract, adding Mel, and stirring.

Example 6

The feed is prepared from the following raw materials in parts by weight: 10 parts of lilium brownie, 25 parts of drynaria fortunei, 30 parts of chrysanthemum tenuifolius, 25 parts of azalea, 30 parts of podophyllum hexandrum, 3-6 parts of honey and 350 parts of groundsel (groundsel of honeysuckle and groundsel of white back according to the mass ratio of 2: 1);

the preparation method comprises the following steps:

2) distilling herba Senecionis Scandentis with water, condensing vapor, and collecting volatile oil of herba Senecionis Scandentis;

3) pulverizing dried Bulbus Lilii, herba Dendrobii, flos Chrysanthemi Indici, flos Rhododendri Simsii and radix Podophylli, adding 70 vol% ethanol solution, heating and reflux extracting, filtering to obtain filtrate, concentrating the filtrate, drying to obtain extract, adding herba Senecionis Scandentis volatile oil, adding Mel, and stirring.

The use method of the invention comprises the following steps:

uniformly mixing the ointment and an alcohol water solution according to the proportion of 1:30 to prepare a liquid medicine, soaking the liquid medicine by using a pure cotton non-woven fabric to apply the liquid medicine onto the skin of an affected part, wherein the alcohol water solution accounts for 95-97% of the volume percentage, applying the liquid medicine to the non-woven fabric thoroughly, applying the liquid medicine for 1 time every day, and taking 15 days as 1 treatment course; the chloasma and sunburn are effective after 2 courses of treatment, and are cured after 5-6 courses of treatment. The acne is effective after 15 days and cured in 3 courses.

During the application period, spicy food and tobacco and wine are prohibited to be eaten, and the sleep is ensured to be more than 8 hours every day.

The main symptoms are as follows:

main symptoms of chloasma: is better for women, especially women in gestation period, after delivery and oral contraceptive. The rash is symmetrically distributed on the skin of face, forehead, cheeks, two sides of back of nose, around lips and chin, and appears as light brown or dark brown dark spot with irregular finger cover to coin size or palm size and shape, and can be fused into large tablets with obvious or unclear border. No subjective symptoms, chronic course, and aggravation after sun exposure. Some of which may slowly resolve after delivery or after withdrawal of the contraceptive.

The main symptoms of sunburn: the color of the product is mainly dark brown color spot or light brown color spot. It is easy to appear on the lateral side of forearm, back of hand, anterior side of calf and face, about the size of rice to pentagonal coin. The early stage of symptoms is pain, itching, desquamation and later stage is mottle. Sunburn is generally characterized by edematous erythema on the skin of the exposed area within hours after exposure to the sun, which can form blisters, often accompanied by burning, itching or stinging.

The main symptoms of acne are: referred to as acne vulgaris, the lesions begin as conical papules conforming to the follicular orifice, with a yellowish white tip consisting of sebum within the follicle and keratinocytes sloughed off from the follicular wall, and a blackhead deposit of melanin, such as a black head squeezed with a finger and a white translucent plug of fat in the body, characteristic of acne and of an earlier-onset lesion. The mild is only the folliculo-oral comedones, and has no pimples. The inflammatory papules are formed around the blackheads when the blackheads are more serious. If the inflammation is exacerbated, large pimples from rice to pea may appear on the apex, which may break or be absorbed leaving temporary pigmentation or small crater-like scars. If the inflammation continues to enlarge and deepen, there are pale red or dark red nodules of different sizes or slightly raised above the surface of the skin. Such lesions may be present for a longer period of time, or may be absorbed gradually, or may form scars after suppuration and rupture. Some lesions are oval cysts from soybeans to the tips of fingers, are dark red or normal skin color, have wave motion during extrusion, often have no serious inflammatory reaction, are not healed for a long time, can suppurate to form abscess, and form polymerized acne when a plurality of nearby abscesses are converged.

Clinical trial

According to the improvement condition of the symptoms, the treatment is divided into recovery, effect and ineffectiveness; the recovery is that all symptoms of the patient are completely relieved within the course of treatment; the effect is that the symptoms suffered by the patient are partially relieved within the course of treatment. The ineffectiveness means that the symptoms of the patients do not improve within the course of treatment. According to the above, the total effective rate is the sum of the total cure rate and the partial effective rate.

Clinical experiment for chloasma

In each example, 40 cases are randomly selected, and the age of the case is 40-55 years. The Tibetan medicines of examples 1-6 are applied to patients respectively, and one Tibetan medicine of example is applied to each case until the treatment course is finished. The treatment effect is counted after 6 treatment courses, and is shown in table 1.

TABLE 1 statistics of the treatment effect on chloasma in patients

。

As can be seen from the table 1, the effective rate of the chloasma of the patient is 85-98%. Compared with the example 1, the cure rate and the effective rate of the example 6 are obviously improved.

Second, clinical experiments on sunburn

In each example, 40 cases are randomly selected, and the age of the case is 40-55 years. The Tibetan medicines of the embodiments 1 to 6 are respectively used for patients, and the Tibetan medicine of one embodiment is attached to each case until the treatment course is finished. The treatment effect is counted after 6 treatment courses, and is shown in table 1.

TABLE 2 patient Sulzer treatment statistics

。

As can be seen from the table 2, the cure rate of the sunburn reaches 70-81%, and the effective rate is 88-99%. Compared with example 1, the efficiency of example 6 is obviously improved.

Third, acne clinical experiment

In each example, 80 cases were randomly selected, and the age of the cases ranged from 14 to 25 years. The Tibetan medicines of the embodiments 1 to 6 are respectively used for patients, and the Tibetan medicine of one embodiment is attached to each case until the treatment course is finished. The treatment effect was counted after 3 treatment courses, and is shown in table 1.

TABLE 3 statistics of acne efficacy in patients

。

As can be seen from Table 3, the acne cure rate reaches 80-93%, and the effective rate is 100%. The recovery rate was significantly improved in example 6 compared to example 1.

The foregoing is directed to preferred embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow. However, any simple modification, equivalent change and modification of the above embodiments according to the technical spirit of the present invention may be made without departing from the technical spirit of the present invention.

Claims

1. The Tibetan medicine medicament is characterized by comprising the following raw materials in parts by weight: 8-12 parts of lilium caput-jobi, 21-29 parts of drynaria fortunei, 26-34 parts of filifolium filiformis, 21-29 parts of rhododendron, 26-34 parts of sinopodophyllum hexandrum and 1-15 parts of honey.

2. The Tibetan medicament of claim 1, comprising the following raw materials in parts by weight: 9-11 parts of lilium caput-medusae, 23-27 parts of drynaria fortunei, 28-32 parts of filifolium filiformis, 23-27 parts of rhododendron, 28-32 parts of sinopodophyllum hexandrum and 2-10 parts of honey.

3. The Tibetan medicament of claim 1, comprising the following raw materials in parts by weight: 10 parts of lily, 25 parts of drynaria fortunei, 30 parts of chrysanthemum tenuifolium, 25 parts of azalea, 30 parts of podophyllum hexandrum and 3-6 parts of honey.

4. The Tibetan medicament of claim 1, further comprising the following raw materials in parts by weight: 300-400 parts of groundsel.

5. The Tibetan medicament of claim 4, wherein: the extraction method of the groundsel comprises the following steps: extracting volatile oil of herba Senecionis Scandentis by water distillation.

6. The Tibetan medicament of claim 4, wherein: the groundsel is at least one of groundsel, groundsel and groundsel.

7. The Tibetan medicament of claim 4, wherein: the groundsel is prepared by mixing senecio scandens and senecio albbacking according to a mass ratio of 2-3: 1 and mixing to obtain the product.

8. A Tibetan medicament according to claim 1, wherein: the honey is China native honey or discharged honey.

9. The preparation method of the Tibetan medicine preparation as claimed in any one of claims 1 to 3, which is characterized by comprising the following steps: