CN107412617A - A kind of Chinese medicine composition for treating pregnant eczema of vulva and preparation method thereof - Google Patents

A kind of Chinese medicine composition for treating pregnant eczema of vulva and preparation method thereof Download PDF

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CN107412617A
CN107412617A CN201710664964.XA CN201710664964A CN107412617A CN 107412617 A CN107412617 A CN 107412617A CN 201710664964 A CN201710664964 A CN 201710664964A CN 107412617 A CN107412617 A CN 107412617A
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chinese medicine
eczema
vulva
pregnant
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于瑞霞
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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Abstract

The invention belongs to gynecological and obstetrical nursing treatment technology field, more particularly to a kind of Chinese medicine composition for treating pregnant eczema of vulva and preparation method thereof.Wherein endo-medicine is made up of the component of following mass fraction:57 parts of the coptis, 35 parts of Chinese lobelia, 46 parts of yncaria stem with hooks, 46 parts of coix seed, 35 parts of oriental wormwood, 46 parts of schizonepeta, windproof 46 parts, 35 parts of the root of Dahurain angelica, 57 parts of peppermint, 35 parts of cicada slough, 57 parts of golden cypress, 57 parts of radix glycyrrhizae, 35 parts of radix cynanchi bungei, 35 parts of Poria cocos, 35 parts of pollen pini.External used medicine is made up of the component of following mass fraction:35 parts of scutellaria, 57 parts of honeysuckle, 57 parts of the capsule of weeping forsythia, 35 parts of rhizoma typhonii, 35 parts of Chinese gall, 57 parts of calcined gypsum, 35 parts of the bark of the root or stem of the tree of heaven, 46 parts of radix rehmanniae recen, 12 parts of borneol, 46 parts of lalang grass rhizome.The present invention carries out the treatment of eczema of vulva and the improvement of allergic constitution using oral traditional Chinese medicine preparation, while is aided with external used medicine anti-inflammatory anti-itch, and have no side effect good effect.

Description

A kind of Chinese medicine composition for treating pregnant eczema of vulva and preparation method thereof
Technical field
The invention belongs to gynecological and obstetrical nursing treatment technology field, more particularly to a kind of Chinese medicine group for treating pregnant eczema of vulva Compound and preparation method thereof.
Background technology
Eczema of vulva is a kind of common non-infectious skin disease, and lesion is confined to perineum and clitoris more, also even to have sprawling To buttocks, erythema, erythema, erosion are locally may occur in which, oozes out, form a scab, furfur, course of disease length, perineum surrounding skin often thickens, color Greyish white or dark red, coarse, so that chap occurs, oozes out, itch, recurrent exerbation are main feature, and any age can fall ill.From From the point of view of in pathogenesis, eczema of vulva is mainly a kind of delayed allergy as caused by the inside and outside motivating factor of complexity.But Its cause of disease to the characteristics of property, the immune response of allergen and with IgE mediation delayed response it is whether related, not yet explain completely It is bright.
Gestational period hormone in vivo level produces great variety, and local nerve function sensitive improves therewith, and Weidner etc. is Confirm that local nerve function sensitive improves and occur with eczema of vulva clearly related, it is interior to be in approach:Nerve fibre and hypertrophy Cell occurs directly to contact by Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, can make mast cell degranulation releasing histamine, cause itch.So it is different from other Allergic dermatitis allergic eczema, even if gestational period eczema removes some sensitizing factors, eczema lesion will not disappear quickly, so existing eczema Treatment means are for gestational vulvareczema effect and unsatisfactory.
The content of the invention
Present invention solves the technical problem that it is even if that gestational period eczema removes some sensitizing factors, eczema lesion will not be quickly Disappear, so existing eczema treatment means are for gestational vulvareczema effect and unsatisfactory.
To solve the above problems, the present invention provides a kind of Chinese medicine composition for treating pregnant eczema of vulva, wherein medicine for oral administration Thing is made up of the component of following mass fraction:Coptis 5-7 parts, Chinese lobelia 3-5 parts, yncaria stem with hooks 4-6 parts, coix seed 4-6 parts, oriental wormwood 3- 5 parts, it is schizonepeta 4-6 parts, windproof 4-6 parts, root of Dahurain angelica 3-5 parts, peppermint 5-7 parts, cicada slough 3-5 parts, golden cypress 5-7 parts, radix glycyrrhizae 5-7 parts, white Tuber of multiflower knotweed 3-5 parts, Poria cocos 3-5 parts, pollen pini 3-5 parts.
Further optimization, is made up of the component of following mass fraction:6 parts of the coptis, 4 parts of Chinese lobelia, 5 parts of yncaria stem with hooks, coix seed 5 Part, 4 parts of oriental wormwood, 5 parts of schizonepeta, windproof 5 parts, 4 parts of the root of Dahurain angelica, 6 parts of peppermint, 4 parts of cicada slough, 6 parts of golden cypress, 6 parts of radix glycyrrhizae, 4 parts of radix cynanchi bungei, 4 parts of Poria cocos, 4 parts of pollen pini.
External used medicine is made up of the component of following mass fraction:It is scutellaria 3-5 parts, honeysuckle 5-7 parts, capsule of weeping forsythia 5-7 parts, white attached Sub- 3-5 parts, Chinese gall 3-5 parts, calcined gypsum 5-7 parts, the bark of the root or stem of the tree of heaven 3-5 parts, radix rehmanniae recen 4-6 parts, borneol 1-2 parts, lalang grass rhizome 4-6 parts.
Further optimization, is made up of the component of following mass fraction:4 parts of scutellaria, 6 parts of honeysuckle, 6 parts of the capsule of weeping forsythia, rhizoma typhonii 4 Part, 4 parts of Chinese gall, 6 parts of calcined gypsum, 4 parts of the bark of the root or stem of the tree of heaven, 5 parts of radix rehmanniae recen, 1 part of borneol, 5 parts of lalang grass rhizome.
The preparation method of endo-medicine comprises the steps of:
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4-10 DEG C under the conditions of refrigerate 12-24h, then at -10~-18 DEG C Lower freezing 10-20h is standby;After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, is carried High cellular damage rate, laid the first stone for the microwave bulking of next step.
(2) temperature in microwave storehouse is set as 110-130 DEG C, microwave storehouse is preheated, and then puts into 1-2kg steps (1) Chinese medicine material after freezing processing, regulation microwave power are 450-600w, and operation 120-180s carries out microwave bulking;Then by temperature Degree is adjusted to 40-80 DEG C, microwave power 90-120w, dries 6-9min;It is swollen that Chinese medicine after freezing is directly carried out to microwave To change, the strength for being directly changed into the distillation of gas moment from ice using hydrone completes puffing process, does not then have to take out Chinese medicine, Directly be dried using microwave, in dry process open stirring, Chinese medicine during stirring uniform drying and because Microwave bulking, which is dried, to become fragile, and disintegrating slag is broken into naturally in whipping process, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed;Further crush can cause medicinal material powder End is homogeneous, and various active ingredients further separate out, beneficial to importing.
(4) the addition protease of the Chinese medicine material after crushing is weighed in proportion to be digested.Bioprotein after enzymolysis divides greatly Son has been cut into small molecular protein and polypeptide, avoids allergic reaction caused by high molecular weight protein, at the same small molecular protein and Polypeptide is more easy to absorb, and works faster.
(5) according to 1:100~1:500 solid-liquid ratio soaks ultrafiltration after 12~24h in ethanol.Pole after ethanol extracts Property composition be readily dissolved in body fluid, be oriented to target location, it is quick;Macromolecular is further filtered in ultrafiltration, and what is left is that biology is small Molecule, work faster.
(6) liquid after ultrafiltration is sealed after microwave disinfection.Microwave disinfection avoid high temperature sterilization to effectively into The destruction divided, drug effect are more preferable.
Further, stage drying is used after step (2) microwave bulking, i.e., it is 70-80 DEG C to adjust temperature first, work( Rate 110-120w, dry 2-3min;Then it is 50-70 DEG C, power 100-110w to adjust temperature, dries 2-3min;Finally adjust Temperature is 40-50 DEG C, power 90-100w, dries 2-3min.
Further, the pulverization conditions of the step (3) are to shut down 3min, then anti-mill after 15min is just being ground using ball mill 3min is shut down after 15min, so repeatedly 2 times.
Further, the protease in the step (4) is alkali protease, neutral proteinase, papain or pancreas One or more in protease.It is demonstrated experimentally that taking the effect of drugs after several protease hydrolyzeds of the above optimal, and pass through egg Medicine after white enzyme enzymolysis eliminates high molecular weight protein, can prevent because of drug-induced allergy.
Further, the molecular weight that milipore filter retains in the step (5) is 15000-20000.It is demonstrated experimentally that molecular weight It is to retain the most molecular weight of active ingredient for 15000-20000, and it is rapid-action, effect is good.
Further, step (6) the microwave disinfection condition is 70 DEG C -105 DEG C, second time 90-180.It can kill Farthest retain active ingredient on the basis of microorganism not to be destroyed.
The preparation method of external used medicine comprises the steps of:
(1) raw mill is diluted after adding water with 60% ethanol as solvent into fine powder, using percolation, collects primary filtrate Enter a bottle A, continue to be percolated, until filtrate is visually observed as colourless stopping;
(2) filtrate is collected, paste is concentrated under reduced pressure at 40-60 DEG C, is mixed after the primary filtrate mixing added in bottle A Liquid;
(3) above-mentioned mixed liquor is diluted with 60% ethanol again, stands 30 hours, after filtering, obtain supernatant liquid as in this The liquid extract of medicine.
Further, the mass ratio of described material quality and water is 1:1.
Application method:Daily oral endo-medicine, a 10-30ml, take the circumstances into consideration to be reduced according to children age, three times a day exist External used medicine is smeared at dermexanthesis.
Toxicity Analysis:
The coptis:There are heat-clearing and damp-drying drug, purging intense heat and detonicating, cool blood bacteriostasis.Demonstrate,proved available for heat toxin sore carbuncle, eczema etc..
Chinese lobelia:There is clearing heat and detoxicating, sharp water clearing damp to act on.Available for treatment skin eczema, sore.
Yncaria stem with hooks:There are The flat liver of heat-clearing, Inflammation Zhijing effect.There is antihistamine effect.
Coix seed:Have that clearing heat and promoting diuresis, invigorating the spleen be antipruritic, diuresis apocenosis effect.Modern times are usually used in anaphylactia auxiliary treatment.
Oriental wormwood:There are clearing heat and promoting diuresis, normalizing gallbladder to cure jaundice, wind-dispelling effect.Also skin heat symptoms caused by an exopathgen can be dissipated and dispelling wind and arresting itching, for rheumatism Condense urticaria, pruitus of skin etc..Pruitus, eczema, pruigo etc. can be treated with lotus leaf compatibility.
Schizonepeta:There is inducing sweat and dispelling exogenous evils, declare malicious promoting eruption, and blood anastalsis, go out impermeable, sore etc. for rubella pruigo, rash.With Be the basis of dispelling wind and arresting itching prescription during windproof compatibility, available for rubella, pruitus etc. demonstrate,prove, often with frutus cnidii, smilax, cicada slough Etc. being used cooperatively.This product can promote skin blood circulation to strengthen, and have slight antipyretic effect.Skin infection disease can be promoted The healing of disease and the absorption of disease damage tissue.
It is windproof:There are cold dispelling solution mark, expel endogenous wind to relieve convulsion, expelling wind and relieving convulsion, itching-relieving action.For rubella of the ailment said due to cold or exposure gram in skin, addiction Rash, sore etc. are demonstrate,proved.Often with schizonepeta compatible use.
The root of Dahurain angelica:Expel pathogenic wind from the body surface, saturating hair key, clearing the nasal passage, eliminating cold to stop pain, eliminating dampness detoxication.The kind wind for controlling head skin, External application can treat cutaneous pruritus.This product can reduce bronchial secretion, coronary artery dilator;The suction of destroyed tissue can be promoted Receive, play the role of to promote to absorb to chronic ulcer, scytitis or promote it to suppurate.
Peppermint:There are dispersing wind, relieving exterior syndrome, promoting qi circulation and removing obstruction in the collateral, dispelling wind and arresting itching, the effect of saturating macula.Demonstrate,proved available for pruitus, rubella etc.. It is that one of clinical herbal pair is used for general rubella, postmeasles pruitus with cicada slough, can also improves geroderma itch And psoriasis pruritis.
Cicada slough:There are dispelling wind and heat from the body, inducing diaphoresis promoting eruption, wind-dispelling only frightened effect.Recent studies thinks that cicada slough can reduce reflex muscular Nervous reaction, the tonicity for reducing striated muscle, there is slight blocking effect to neuromere.
Golden cypress:There are heat-clearing and damp-drying drug, purging intense heat and detonicating, nourishing Yin and falling fire effect.It is used for sore swollen toxin, eczema with rhizoma atractylodis compatibility, itches The diseases such as rash.External application is ground with talcum, is treatment wet sore, eczema obstruction-removing prescription.
Radix glycyrrhizae:There are clearing heat and detoxicating, mediation property of medicine, expelling phlegm and arresting coughing effect, and can invigorating spleen, relieving spasm to stop pain.This product is to people Extensive, the contained glycyrrhizin enoxolone of body effect, there is the suppression inflammation of similar cortex hormone of aadrenaline and mineralocorticoid, resist Allergy acts on.
Radix cynanchi bungei:Bitter but sweet flavor is puckery, slightly warm in nature, nontoxic;Enter liver, kidney two warp.Effect is nourishing liver and kidney, strengthening body, and blood-nourishing is mended Blood, crow palpus dark hair, restrains vital essence, myogenic sore, relaxes bowel.Cure mainly prolonged illness weakness, chronic wandering arthritis, soreness and weakness of waist and knees, anaemia, intestines Bleeding, poliosis, neurasthenia, deficiency of Yin chronic malaria, ulcer do not close up long, old people constipation.
Poria cocos:With anti-oxidant, anti-aging, increase immunity, the effect of raising brain cell activity.Poria cocos has stronger Diuresis, ephritis, heart failure oedema can be treated.There is sedation in addition, it is effective to neurasthenia.It is lightly seasoned mild-natured, it is apt to QI invigorating Blood-nourishing, antitoxic heart-soothing and sedative, internal heat anticance;Mild in medicine property and, for dampness removing without hindering healthy tendency, contained pachymic acid has strengthen immunity, anti-swollen Knurl and the effect of calmness, hypoglycemic etc.;Can be relaxed gastrointestinal smooth muscle, gastric acid secretion inhibiting, prevent necrosis of liver cells, antibacterial And other effects.
Pollen pini:It is warm-natured, it is sweet.The effect of with nourishing qi and blood, soothing the liver wind-dispelling, hygroscopic, hemostasis;Head rotation dizziness is cured mainly, Middle void has a stomach-ache, protracted dysentery, and all sores are wet rotten, traumatic bleeding.
Scutellaria:There is the effect such as help spleen soil, strengthening exterior and reducing sweat, torr sore myogenic.The blood circulation of sore tissue can be improved, promoted The absorption or suppuration of pathological tissues.
Honeysuckle:Have clearing heat and detoxicating, antiinflammatory action, can control inflammation ooze out and inflammatory hyperplasia, leucocyte can be promoted Phagocytic function, there is inhibitory action to a variety of pyococcus, skin infection can be controlled.
The capsule of weeping forsythia:There are clearing heat and detoxicating, dispersing swelling and dissipating binds.This product has powerful antiinflammatory and bacteriostatic functions, to aseptic inflammation Have it is obvious it is impervious go out, reduce the effect of lesions position capillary fragility.
Rhizoma typhonii:There is the effect such as wind-dispelling slit phlegm, dredging collateral, Sweeling-eliminating medicine powder section.Fresh goods external application is smash deposited, can treat eczema.
Chinese gall:There are the puckery intestines of convergence, fall fire of astringing the lung, removing toxic substances sore.Available for eczema sore, the prolapse of uterus is wet itches Disease.
Calcined gypsum:There are clearing heat-fire, relieving restlessness of quenching the thirst effect, capillary permeability can be reduced after for oral administration.Rear external application is forged, can Expelling pus and promoting granulation stops blooding, for sore flowing water, eczema, burn and scald etc..
The bark of the root or stem of the tree of heaven:There are heat-clearing and damp-drying drug, hemostasis itching-relieving action.External application can treat the wet card such as itch of sore tinea.
Radix rehmanniae recen:There are clearing heat and cooling blood, the raw new role of silt of dispelling.Available for cards such as the nettle rash caused by treatment blood-head, scalls.
Borneol:Surgery makees liniment and is used for eczema, pruigo, sore prickly heat etc..
Lalang grass rhizome:There are cooling blood and hemostasis, reducing fever and causing diuresis effect.Capillary permeability can be reduced.
Constitution Theory in TCM is divided into human body the constitution of nine types.Modern Chinese medicine antiallergy laboratory current research hair It is existing:Why allergic phenomena can occur for human body, be because the functions such as lung, spleen, kidney are disorderly and body fluid (blood, mucous membrane, jaundice Juice, four big body fluid of black bile) it is unbalance, cause to tremble with fear, be wet, malicious savings it is internal, decline immunity of organism protection capability and cause allergy body Matter.When in environmental stimuli material (i.e. anaphylactogen) arbitrarily invasion contact respiratory mucosa, gastrointestinal tract mucosa, skin connective tissue Mast cell and basophil and reacting to form itch, oedema, hyperemia, a series of allergic reactions such as fester, absolutely not General inflammation.Because allergy proper energy stimulates body to start specific immune mechanisms, and produces allergic reaction.The allergy not being avoided that Former external cause stimulates, and allows people to feel very painful, and seeks medicine to improve symptom.Drug type mainly has:External application hormone is quick Improving skin symptom, injection or oral Loratadine makes allergic reaction be eased, but because can not fundamentally hinder Only abnormal allergic reaction, so can only stop just to violate, recurrent exerbation, and it can not really improve allergic constitution.Therefore want thoroughly Anaphylactic disease is cured, must just extract cold, wet, malicious in internal organs and body fluid, adjustment spleen, kidney, the function such as lung, body fluid is adjusted and puts down Weighing apparatus, function of immune system is recovered normal, body injury caused by repairing various allergy, thoroughly improve allergic constitution, improve people Resistance defence capability of the body to various anaphylactogens, fine and close protection network is established on mucous membrane tissue top layer, could fundamentally be blocked Anaphylactogen is invaded, even if running into anaphylactogen again, will not also be had an attack of one's old illness again.
The Chinese medical extract sheerly Chinese medicine preparation of the present invention, it is nontoxic and harmless to fetus and pregnant woman, pass through oral traditional Chinese medicine Preparation carries out the treatment of eczema of vulva and the improvement of allergic constitution, while is aided with external used medicine local action, anti-inflammatory anti-itch, nothing Side effect good effect.Wherein, the coptis, Chinese lobelia, yncaria stem with hooks, coix seed, oriental wormwood have the function that dampness removing heat-clearing;It is schizonepeta, windproof, white The root of Dahurian angelica, peppermint, cicada slough, which have, declares malicious promoting eruption effect;Golden cypress, radix glycyrrhizae, radix cynanchi bungei, Poria cocos, pollen pini have the function that nourishing yin and nourishing blood; Scutellaria, honeysuckle, the capsule of weeping forsythia, rhizoma typhonii, Chinese gall have the function that anti-inflammation and sterilization, and external application avoids the inflammatory reaction of allergy, forges stone Cream, the bark of the root or stem of the tree of heaven, radix rehmanniae recen, borneol, lalang grass rhizome have the function that antipyretic and itching-stopping, alleviate discomfort caused by eczema of vulva.With 200 trouble Exemplified by person, treated using medicine of the present invention, 198 patients are effective, and total effective rate is up to 99%;Compared to only with oral system 97 patients of agent effectively from the point of view of, effective percentage improves 50.5%;Compared to the name patient only with external used medicine 86 effectively from the point of view of, Effective percentage improves 56%.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention, Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is the present invention one Divide embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making The every other embodiment obtained under the premise of creative work, belongs to the scope of protection of the invention.
Embodiment 1:
A kind of Chinese medicine composition for treating pregnant eczema of vulva, it is for oral administration to be made up of the component of following mass fraction:The coptis 6 Part, 4 parts of Chinese lobelia, 5 parts of yncaria stem with hooks, 5 parts of coix seed, 4 parts of oriental wormwood, 5 parts of schizonepeta, windproof 5 parts, 4 parts of the root of Dahurain angelica, 6 parts of peppermint, cicada slough 4 Part, 6 parts of golden cypress, 6 parts of radix glycyrrhizae, 4 parts of radix cynanchi bungei, 4 parts of Poria cocos, 4 parts of pollen pini;External used medicine by following mass fraction component group Into:4 parts of scutellaria, 6 parts of honeysuckle, 6 parts of the capsule of weeping forsythia, 4 parts of rhizoma typhonii, 4 parts of Chinese gall, 6 parts of calcined gypsum, 4 parts of the bark of the root or stem of the tree of heaven, radix rehmanniae recen 5 Part, 1 part of borneol, 5 parts of lalang grass rhizome.
The preparation method of endo-medicine comprises the steps of:
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 6 DEG C under the conditions of refrigerate 20h, at -15 DEG C freeze 15h it is standby With;After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, cellular damage rate is improved, is The microwave bulking of next step lays the first stone.
(2) temperature in microwave storehouse is set as 120 DEG C, microwave storehouse is preheated, and is then put at 1kg steps (1) freezing Chinese medicine material after reason, regulation microwave power are 500w, and operation 160s carries out microwave bulking;Then it is 60 DEG C by temperature adjustment, Microwave power is 100w, dries 9min;Chinese medicine after freezing is directly subjected to microwave bulking, directly become from ice using hydrone Strength for the distillation of gas moment completes puffing process, does not then have to take out Chinese medicine, is directly dried using microwave, is done In dry process open stirring, Chinese medicine during stirring uniform drying and because microwave bulking dry become fragile, stirring During be broken into disintegrating slag naturally, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed;Further crush can cause medicinal material powder End is homogeneous, and various active ingredients further separate out, beneficial to importing.
(4) the addition protease of the Chinese medicine material after crushing is weighed in proportion to be digested.Bioprotein after enzymolysis divides greatly Son has been cut into small molecular protein and polypeptide, avoids allergic reaction caused by high molecular weight protein, at the same small molecular protein and Polypeptide is more easy to absorb, and works faster.
(5) according to 1:300 solid-liquid ratio soaks ultrafiltration after 12~24h in ethanol.Polar component after ethanol extracts It is readily dissolved in body fluid, is oriented to target location, it is quick;Macromolecular is further filtered in ultrafiltration, and what is left is biological micromolecule, rises Effect is faster.
(6) liquid after ultrafiltration is sealed after microwave disinfection.Microwave disinfection avoid high temperature sterilization to effectively into The destruction divided, drug effect are more preferable.
Stage drying is used after step (2) microwave bulking, i.e., it is 75 DEG C, power 115w to adjust temperature first, is dried 3min;Then it is 60 DEG C, power 105w to adjust temperature, dries 3min;It is 45 DEG C, power 95w finally to adjust temperature, is dried 3min。
The pulverization conditions of the step (3) are to shut down 3min after 15min is just being ground using ball mill, then are stopped after instead grinding 15min Machine 3min, so repeatedly 2 times.
Protease in the step (4) is in alkali protease, neutral proteinase, papain or trypsase It is one or more of.It is demonstrated experimentally that take the effect of drugs after several protease hydrolyzeds of the above optimal.
The molecular weight that milipore filter retains in the step (5) is 18000.
Step (6) the microwave disinfection condition is 85 DEG C, 160 seconds time.Can be maximum on the basis of microorganism is killed The reservation active ingredient of degree is not destroyed.
The preparation method of external used medicine comprises the steps of:
(1) raw mill is diluted after adding water with 60% ethanol as solvent into fine powder, using percolation, collects primary filtrate Enter a bottle A, continue to be percolated, until filtrate is visually observed as colourless stopping;
(2) filtrate is collected, paste is concentrated under reduced pressure at 50 DEG C, mixed liquor is obtained after the primary filtrate mixing added in bottle A;
(3) above-mentioned mixed liquor is diluted with 60% ethanol again, stands 30 hours, after filtering, obtain supernatant liquid as in this The liquid extract of medicine.
Described material quality and the mass ratio of water are 1:1.
Embodiment 2:
A kind of Chinese medicine composition for treating pregnant eczema of vulva, it is for oral administration to be made up of the component of following mass fraction:The coptis 5 Part, 5 parts of Chinese lobelia, 4 parts of yncaria stem with hooks, 6 parts of coix seed, 3 parts of oriental wormwood, 6 parts of schizonepeta, windproof 4 parts, 5 parts of the root of Dahurain angelica, 5 parts of peppermint, cicada slough 5 Part, 5 parts of golden cypress, 7 parts of radix glycyrrhizae, 3 parts of radix cynanchi bungei, 5 parts of Poria cocos, 3 parts of pollen pini;External used medicine by following mass fraction component group Into:5 parts of scutellaria, 5 parts of honeysuckle, 7 parts of the capsule of weeping forsythia, 3 parts of rhizoma typhonii, 5 parts of Chinese gall, 5 parts of calcined gypsum, 5 parts of the bark of the root or stem of the tree of heaven, radix rehmanniae recen 4 Part, 2 parts of borneol, 4 parts of lalang grass rhizome.
The preparation method of endo-medicine comprises the steps of:
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4 DEG C under the conditions of refrigerate 24h, at -10 DEG C freeze 20h it is standby With;After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, cellular damage rate is improved, is The microwave bulking of next step lays the first stone.
(2) temperature in microwave storehouse is set as 110 DEG C, microwave storehouse is preheated, and is then put at 2kg steps (1) freezing Chinese medicine material after reason, regulation microwave power are 450w, and operation 180s carries out microwave bulking;Then it is 40 DEG C by temperature adjustment, Microwave power is 120w, dries 8min;Chinese medicine after freezing is directly subjected to microwave bulking, directly become from ice using hydrone Strength for the distillation of gas moment completes puffing process, does not then have to take out Chinese medicine, is directly dried using microwave, is done In dry process open stirring, Chinese medicine during stirring uniform drying and because microwave bulking dry become fragile, stirring During be broken into disintegrating slag naturally, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed;Further crush can cause medicinal material powder End is homogeneous, and various active ingredients further separate out, beneficial to importing.
(4) the addition protease of the Chinese medicine material after crushing is weighed in proportion to be digested.Bioprotein after enzymolysis divides greatly Son has been cut into small molecular protein and polypeptide, avoids allergic reaction caused by high molecular weight protein, at the same small molecular protein and Polypeptide is more easy to absorb, and works faster.
(5) according to 1:100 solid-liquid ratio soaks ultrafiltration after 24h in ethanol.Polar component after ethanol extracts is easy to It is dissolved in body fluid, is oriented to target location, it is quick;Macromolecular is further filtered in ultrafiltration, and what is left is biological micromolecule, works more It hurry up.
(6) liquid after ultrafiltration is sealed after microwave disinfection.Microwave disinfection avoid high temperature sterilization to effectively into The destruction divided, drug effect are more preferable.
Further, stage drying is used after step (2) microwave bulking, i.e., it is 70 DEG C to adjust temperature first, power 110w, dry 3min;Then it is 50 DEG C, power 110w to adjust temperature, dries 2min;It is 50 DEG C finally to adjust temperature, power 90w, dry 3min.
Further, the pulverization conditions of the step (3) are to shut down 3min, then anti-mill after 15min is just being ground using ball mill 3min is shut down after 15min, so repeatedly 2 times.
Protease in the step (4) is in alkali protease, neutral proteinase, papain or trypsase It is one or more of.It is demonstrated experimentally that take the effect of drugs after several protease hydrolyzeds of the above optimal.
The molecular weight that milipore filter retains in the step (5) is 15000.
Step (6) the microwave disinfection condition is 105 DEG C, 90 seconds time.Can be maximum on the basis of microorganism is killed The reservation active ingredient of degree is not destroyed.
The preparation method of external used medicine comprises the steps of:
(1) raw mill is diluted after adding water with 60% ethanol as solvent into fine powder, using percolation, collects primary filtrate Enter a bottle A, continue to be percolated, until filtrate is visually observed as colourless stopping;
(2) filtrate is collected, paste is concentrated under reduced pressure at 40 DEG C, mixed liquor is obtained after the primary filtrate mixing added in bottle A;
(3) above-mentioned mixed liquor is diluted with 60% ethanol again, stands 30 hours, after filtering, obtain supernatant liquid as in this The liquid extract of medicine.
Described material quality and the mass ratio of water are 1:1.
Embodiment 3:
A kind of Chinese medicine composition for treating pregnant eczema of vulva, it is for oral administration to be made up of the component of following mass fraction:The coptis 7 Part, 3 parts of Chinese lobelia, 6 parts of yncaria stem with hooks, 4 parts of coix seed, 5 parts of oriental wormwood, 4 parts of schizonepeta, windproof 6 parts, 3 parts of the root of Dahurain angelica, 7 parts of peppermint, cicada slough 3 Part, 7 parts of golden cypress, 5 parts of radix glycyrrhizae, 5 parts of radix cynanchi bungei, 5 parts of Poria cocos, 5 parts of pollen pini;External used medicine by following mass fraction component group Into:5 parts of scutellaria, 7 parts of honeysuckle, 5 parts of the capsule of weeping forsythia, 5 parts of rhizoma typhonii, 3 parts of Chinese gall, 7 parts of calcined gypsum, 3 parts of the bark of the root or stem of the tree of heaven, radix rehmanniae recen 6 Part, 1 part of borneol, 6 parts of lalang grass rhizome.
The preparation method of endo-medicine comprises the steps of:
(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 10 DEG C under the conditions of refrigerate 12h, freeze 10h at -18 DEG C It is standby;After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, improves cellular damage rate, Laid the first stone for the microwave bulking of next step.
(2) temperature in microwave storehouse is set as 130 DEG C, microwave storehouse is preheated, and is then put at 1kg steps (1) freezing Chinese medicine material after reason, regulation microwave power are 600w, and operation 120s carries out microwave bulking;Then it is 80 DEG C by temperature adjustment, Microwave power is 90w, dries 7min;Chinese medicine after freezing is directly subjected to microwave bulking, directly become from ice using hydrone Strength for the distillation of gas moment completes puffing process, does not then have to take out Chinese medicine, is directly dried using microwave, is done In dry process open stirring, Chinese medicine during stirring uniform drying and because microwave bulking dry become fragile, stirring During be broken into disintegrating slag naturally, beneficial to the crushing in later stage.
(3) Chinese medicine after step (2) processing is put into ball mill and crushed;Further crush can cause medicinal material powder End is homogeneous, and various active ingredients further separate out, beneficial to importing.
(4) the addition protease of the Chinese medicine material after crushing is weighed in proportion to be digested.Bioprotein after enzymolysis divides greatly Son has been cut into small molecular protein and polypeptide, avoids allergic reaction caused by high molecular weight protein, at the same small molecular protein and Polypeptide is more easy to absorb, and works faster.
(5) according to 1:500 solid-liquid ratio soaks ultrafiltration after 12h in ethanol.Polar component after ethanol extracts is easy to It is dissolved in body fluid, is oriented to target location, it is quick;Macromolecular is further filtered in ultrafiltration, and what is left is biological micromolecule, works more It hurry up.
(6) liquid after ultrafiltration is sealed after microwave disinfection.Microwave disinfection avoid high temperature sterilization to effectively into The destruction divided, drug effect are more preferable.
Stage drying is used after step (2) microwave bulking, i.e., it is 80 DEG C, power 110w to adjust temperature first, is dried 2min;Then it is 70 DEG C, power 100w to adjust temperature, dries 3min;It is 50 DEG C, power 100w finally to adjust temperature, is dried 2min。
The pulverization conditions of the step (3) are to shut down 3min after 15min is just being ground using ball mill, then are stopped after instead grinding 15min Machine 3min, so repeatedly 2 times.
Protease in the step (4) is in alkali protease, neutral proteinase, papain or trypsase It is one or more of.It is demonstrated experimentally that take the effect of drugs after several protease hydrolyzeds of the above optimal.
The molecular weight that milipore filter retains in the step (5) is 20000.
Step (6) the microwave disinfection condition is 105 DEG C, 90 seconds time.Can be maximum on the basis of microorganism is killed The reservation active ingredient of degree is not destroyed.
The preparation method of external used medicine comprises the steps of:
(1) raw mill is diluted after adding water with 60% ethanol as solvent into fine powder, using percolation, collects primary filtrate Enter a bottle A, continue to be percolated, until filtrate is visually observed as colourless stopping;
(2) filtrate is collected, paste is concentrated under reduced pressure at 60 DEG C, mixed liquor is obtained after the primary filtrate mixing added in bottle A;
(3) above-mentioned mixed liquor is diluted with 60% ethanol again, stands 30 hours, after filtering, obtain supernatant liquid as in this The liquid extract of medicine.
Described material quality and the mass ratio of water are 1:1.

Claims (10)

  1. A kind of 1. Chinese medicine composition for treating pregnant eczema of vulva, it is characterised in that:It is made up of endo-medicine and external used medicine, its Middle endo-medicine is made up of the component of following mass fraction:Coptis 5-7 parts, Chinese lobelia 3-5 parts, yncaria stem with hooks 4-6 parts, coix seed 4-6 Part, oriental wormwood 3-5 parts, schizonepeta 4-6 parts, windproof 4-6 parts, root of Dahurain angelica 3-5 parts, peppermint 5-7 parts, cicada slough 3-5 parts, golden cypress 5-7 parts, radix glycyrrhizae 5-7 parts, radix cynanchi bungei 3-5 parts, Poria cocos 3-5 parts, pollen pini 3-5 parts.
  2. 2. the Chinese medicine composition of pregnant eczema of vulva is treated as claimed in claim 1, it is characterised in that by following mass fraction Component composition:6 parts of the coptis, 4 parts of Chinese lobelia, 5 parts of yncaria stem with hooks, 5 parts of coix seed, 4 parts of oriental wormwood, 5 parts of schizonepeta, the windproof 5 parts, root of Dahurain angelica 4 Part, 6 parts of peppermint, 4 parts of cicada slough, 6 parts of golden cypress, 6 parts of radix glycyrrhizae, 4 parts of radix cynanchi bungei, 4 parts of Poria cocos, 4 parts of pollen pini.
  3. 3. the Chinese medicine composition of pregnant eczema of vulva is treated as claimed in claim 1, it is characterised in that external used medicine is by following The component composition of mass fraction:Scutellaria 3-5 parts, honeysuckle 5-7 parts, capsule of weeping forsythia 5-7 parts, rhizoma typhonii 3-5 parts, Chinese gall 3-5 parts, forge Gypsum 5-7 parts, the bark of the root or stem of the tree of heaven 3-5 parts, radix rehmanniae recen 4-6 parts, borneol 1-2 parts, lalang grass rhizome 4-6 parts.
  4. 4. the Chinese medicine composition of pregnant eczema of vulva is treated as claimed in claim 3, it is characterised in that by following mass fraction Component composition:4 parts of scutellaria, 6 parts of honeysuckle, 6 parts of the capsule of weeping forsythia, 4 parts of rhizoma typhonii, 4 parts of Chinese gall, 6 parts of calcined gypsum, 4 parts of the bark of the root or stem of the tree of heaven, 5 parts of radix rehmanniae recen, 1 part of borneol, 5 parts of lalang grass rhizome.
  5. 5. a kind of preparation method for the Chinese medicine composition for treating pregnant eczema of vulva as claimed in claim 1, it is characterised in that interior Medication thing comprises the steps of:
    (1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4-10 DEG C under the conditions of refrigerate 12-24h, it is cold at -10~-18 DEG C It is standby to freeze 10-20h;
    (2) temperature in microwave storehouse is set as 110-130 DEG C, microwave storehouse is preheated, and then puts into 1-2kg steps (1) freezing Chinese medicine material after processing, regulation microwave power are 450-600w, and operation 120-180s carries out microwave bulking;Then temperature is adjusted Save as 40-80 DEG C, microwave power 90-120w, dry 6-9min;
    (3) Chinese medicine after step (2) processing is put into ball mill and crushed;
    (4) the addition protease of the Chinese medicine material after crushing is weighed in proportion to be digested;
    (5) according to 1:100~1:500 solid-liquid ratio soaks ultrafiltration after 12~24h in ethanol;
    (6) liquid after ultrafiltration is sealed after microwave disinfection.
  6. 6. a kind of preparation method for the Chinese medicine composition for treating pregnant eczema of vulva as claimed in claim 3, it is characterised in that outer Comprised the steps of with medicine:
    (1) raw mill is diluted after adding water with 60% ethanol as solvent into fine powder, using percolation, collects primary filtrate and enter bottle A, continue to be percolated, until filtrate is visually observed as colourless stopping;
    (2) filtrate is collected, paste is concentrated under reduced pressure at 40-60 DEG C, mixed liquor is obtained after the primary filtrate mixing added in bottle A;
    (3) above-mentioned mixed liquor is diluted with 60% ethanol again, stands 30 hours, after filtering, obtain supernatant liquid as the Chinese medicine Liquid extract.
  7. 7. the preparation method of the Chinese medicine composition of pregnant eczema of vulva is treated as claimed in claim 5, it is characterised in that:It is described Stage drying is used after step (2) microwave bulking, i.e., it is 70-80 DEG C, power 110-120w to adjust temperature first, dries 2- 3min;Then it is 50-70 DEG C, power 100-110w to adjust temperature, dries 2-3min;It is 40-50 DEG C finally to adjust temperature, power 90-100w, dry 2-3min.
  8. 8. the preparation method of the Chinese medicine composition of pregnant eczema of vulva is treated as claimed in claim 5, it is characterised in that:It is described The pulverization conditions of step (3) are to shut down 3min after 15Min is just being ground using ball mill, then shut down 3min after instead grinding 15min, so anti- It is multiple 2 times.
  9. 9. the preparation method of the Chinese medicine composition of pregnant eczema of vulva is treated as claimed in claim 5, it is characterised in that:It is described Protease in step (4) is the one or more in alkali protease, neutral proteinase, papain or trypsase.
  10. 10. the preparation method of the Chinese medicine composition of pregnant eczema of vulva is treated as claimed in claim 5, it is characterised in that:Institute It is 15000-20000 to state the molecular weight that milipore filter retains in step (5).
CN201710664964.XA 2017-08-07 2017-08-07 A kind of Chinese medicine composition for treating pregnant eczema of vulva and preparation method thereof Withdrawn CN107412617A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115414423A (en) * 2022-09-26 2022-12-02 中国人民解放军海军军医大学 Traditional Chinese medicine composition for treating eczema and application of traditional Chinese medicine composition in preparation of itching-relieving and healing-promoting cream

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