CN104491641A - Fuming and washing medicine for promoting healing of pulled muscles - Google Patents

Fuming and washing medicine for promoting healing of pulled muscles Download PDF

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CN104491641A
CN104491641A CN201410827702.7A CN201410827702A CN104491641A CN 104491641 A CN104491641 A CN 104491641A CN 201410827702 A CN201410827702 A CN 201410827702A CN 104491641 A CN104491641 A CN 104491641A
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parts
radix
fumigation
washing medicine
medicine
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张彦秋
曹江
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Xian Shiyou University
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Xian Shiyou University
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Abstract

The invention discloses a fuming and washing medicine for promoting healing of pulled muscles. The fuming and washing medicine comprises a main material and auxiliary materials, wherein the main material comprises the following raw materials in parts by weight: star-flower lysimachia, asplenium prolongatum hook, Tibetan barberries, stellaria media, pseudo-ginseng processed with gingers, rhizoma acori graminei, armillarialuteo viren, ChloranthuselatiorLink, cocculus orbiculatus, lumbricus, osmanthus roots, common achyranthes herb, lamiophlomis rotate, renanthera, pyrolusite, basket osier roots, acanthus ilicifolius, lycopodium obscurum, fiddleleaf fig root leaves, loose knots and Chinese tallowtree leaves; the auxiliary materials comprise the following raw materials: menthol, bromelain, hyaluronic acid, borneol powder, a skin penetration enhancer, an antioxidant and a suspending agent. The fuming and washing medicine disclosed by the invention is prepared from selected Chinese herbal medicines which have the functions of dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis, relieving swelling and pain, clearing and activating the channels and collaterals and expelling wind and removing cold and are strictly combined according to pharmacological activities of the medicines, so that the fuming and washing medicine is exact in curative effect. The auxiliary materials are matched, so that the medicine is quick to take effect, the treatment course is further shortened and healing is accelerated. The medicine is prepared into a fuming and washing agent which is convenient to use.

Description

A kind of fumigation-washing medicine promoting muscle sprain to heal
Technical field
The present invention relates to technical field of Chinese medicines, specifically relate to a kind of fumigation-washing medicine promoting muscle sprain to heal.
Background technology
The fine damage of muscle that the passive strong contraction of muscle or passive elongation excessively cause, muscle parts are torn or rupture completely, are called muscle sprain.This is one of modal athletic injury.
Muscle sprain early treatment principle is braking, hemostasis, anti-swollen, analgesia, cold compress process, can make affected part vasoconstriction like this and reduce hemorrhage, edema and pain; After 24 to 48 hours, the Chinese medicine such as activating blood circulation to dissipate blood stasis, reducing swelling and alleviating pain can be applied treat, Promotive union.
At present, the medicine of the treatment muscle sprain that market is sold is many, but existing agents alleviate pain is slow, and the cycle of curing is long.And be superficial phenomenon mostly, namely sufferer is by self-recovery, and medicine does not act on substantially.So develop a kind of determined curative effect, short treating period, simple and effective muscle sprain medicine necessary.
Summary of the invention
The technical problem that the present invention solves is to provide the fumigation-washing medicine of a kind of determined curative effect, short treating period, the healing of simple and effective promotion muscle sprain.
Technical scheme of the present invention is as follows:
A kind of fumigation-washing medicine promoting muscle sprain to heal, comprise major ingredient and adjuvant, the raw material composition of wherein said major ingredient and weight portion thereof are: Lysimachia trientaloides Hemsl. 20 ~ 50 parts, determine grass roots 15 ~ 35 parts, Radix Berberidis soulieanae 10 ~ 30 parts, Herba malachii aquatici 12 ~ 40 parts, Radix Camptandrae Yunnanensis 8 ~ 20 parts, Rhizoma Acori Graminei 30 ~ 60 parts, yellow mushroom 12 ~ 18 parts, joint joint tea 30 ~ 60 parts, Radix cocculi laurifolii 14 ~ 30 parts, Pheretima 10 ~ 20 parts, Flos Osmanthi Fragrantis root 6 ~ 18 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 12 ~ 34 parts, Radix Lamiophlomidis Rotatae 21 ~ 35 parts, Herba Renantherae coccineae 10 ~ 28 parts, pyrolusitum 5 ~ 25 parts, Radix Salicis Purpureae 4 ~ 10 parts, Radix seu Caulis Acanthi Ilicifolii 8 ~ 30 parts, Herba Lycopodii Obscuri 16 ~ 40 parts, Radix fici panduratae 2 ~ 10 parts, Lignum Pini Nodi 3 ~ 8 parts, Folium Sapii 3 ~ 15 parts, the constitutive material of described adjuvant and weight portion thereof are: menthol 0.2 ~ 0.5 part, bromelain 0.01 ~ 0.02 part, hyaluronic acid 0.1 ~ 0.3 part, Borneolum Syntheticum 0.4 ~ 0.6 part, Percutaneous absorption enhancer 0.008 ~ 0.012 part, antioxidant 0.005 ~ 0.01 part, suspending agent 0.006 ~ 0.014 part.
Further, described Percutaneous absorption enhancer is selected from one or more the combination in any in Oleum menthae, Oleum Terebinthinae, propylene glycol (PG), Polyethylene Glycol or dimethyl sulfoxide (DMSO).Add Percutaneous absorption enhancer and effectively can promote that medicine infiltrates skin, accelerate drug effect.
Further, described antioxidant is eucalyptus oil.Eucalyptus oil can effectively prevent oxidation of drug, inefficacy.
Further, described suspending agent is one or more the combination in any in sodium carboxymethyl cellulose, sodium alginate or Cera Flava.Owing to having bromelain and hyaluronic acid in adjuvant, so other adjuvants can not select lipid and acids, in order to avoid interact between medicine, reduce drug effect.
Further, described a kind of fumigation-washing medicine promoting muscle sprain to heal, is prepared from by following steps:
(1) get the Lysimachia trientaloides Hemsl. of formula ratio, Herba malachii aquatici, Radix Camptandrae Yunnanensis, Flos Osmanthi Fragrantis root, Radix achyranthis asperae (Herba Achyranthis Asperae), Radix Lamiophlomidis Rotatae, Herba Lycopodii Obscuri, be chopped into fritter, add 6 ~ 8 times of water gagings, reflux, extract, 1 ~ 3 time, each 1 ~ 2 hour, collect aqueous extract; Medicinal residues 65% ~ 75% alcoholic solution reflux, extract, 1 ~ 3 time, add 8 ~ 10 times amount ethanol at every turn, extraction time is 1.5 ~ 2.5 hours, merge extractive liquid, reclaim ethanol, obtain alcohol extract, mix with above-mentioned aqueous extract, filter with inorganic ceramic film, the rate of filtration is 9 ~ 13L/h, collects filtrate, stand-by;
(2) that gets formula ratio determines grass roots, Radix Berberidis soulieanae, Rhizoma Acori Graminei, yellow mushroom, Pheretima, Herba Renantherae coccineae, Radix Salicis Purpureae, Radix fici panduratae, Folium Sapii, cleans up respectively, dries, repeatedly grinds 200 ~ 220 mesh sieves into powder, merges, obtains mixing fine powders, stand-by;
(3) get the fresh joint joint tea of formula ratio, Radix cocculi laurifolii, pyrolusitum, Radix seu Caulis Acanthi Ilicifolii, the clean chopping of Lignum Pini Nodi, with the alcohol in high concentration dipping 12 ~ 24h of 15 ~ 18 times amount, reclaim ethanol, obtain ethanol lixiviating solution, stand-by;
(4) merged by the extract liquid that above-mentioned steps (1) and (3) obtain, the ratio in 1: 1 adds pure water mixing, precipitates with lime cream, removes impurity, obtains pure medicinal liquid, stand-by; Bromelain is a kind of bioactive substance, be subject to suppression and the destruction of heavy metal ion (Fe2+, Cu2+, Hg+, Pb+ etc.) and oxidant, and calcium ion can be combined into calcium chelate, calcium precipitation with the effective ingredient in medicinal liquid and impurity in lime cream, effective heavy-metal ion removal;
(5) medicinal liquid of mixing fine powders obtained for step (2) and step (4) is merged, be heated to 80 ~ 100 DEG C, add proper amount of active carbon, adjust pH to 6.8 ~ 7.2, be cooled to 25 ~ 35 DEG C, filter, adjuvant menthol, Borneolum Syntheticum, Percutaneous absorption enhancer, antioxidant, suspending agent is added successively by formula ratio, limit edged stirs in the same direction, then adds deionized water and reach 20 ~ 25% to active constituent content, sterilizing, add hyaluronic acid, bromelain again, cold preservation, pressurization subpackage, obtains the fumigation-washing medicine of promotion muscle sprain of the present invention healing.
Further, in described preparation process (2), high temperature heat pump seasoning is used in the oven dry of medical material, and temperature controls at 40 ~ 70 DEG C, and relative humidity controls 20 ~ 40%, dries to water content described medical material lower than 15%.The dry energy savings of high temperature heat pump, efficiency is high, and cost is low.
Further, in described preparation process (3), its concentration of described alcohol in high concentration is 85 ~ 90%.Polar organic matter is soluble in polar solvent, and Organic substance is generally more soluble in organic solvent, and the effective ingredient in Chinese herbal medicine is generally polar organic matter, is comparatively soluble in ethanol, so be easy to the effective ingredient of said herbal medicine to extract with alcohol in high concentration.
Further, in described preparation process (5), described sterilizing methods is instantaneous ultrahigh-temperature sterilization, and device therefor is UHT high-temperature short-time sterilization machine.Instantaneous ultrahigh-temperature sterilization method sterilization effect is good, can effectively avoid the activity of the bromelain added to receive impact below.
Further, in described preparation process (5), pressure during described pressurization subpackage is 1.2 ~ 1.25Mpa.
The medical material property of medicine selected by the present invention and effect are:
1. Lysimachia trientaloides Hemsl.: [nature and flavor] are bitter, pungent, temperature.[function cures mainly] expelling wind and removing dampness, promoting blood circulation to remove blood stasis.For rheumatalgia, traumatic injury, fracture.
2. determine grass roots: [nature and flavor] are pungent, sweet, flat.[function cures mainly] removing damp-heat, blood circulation promoting and blood stasis dispelling, relieving cough and resolving phlegm, diuresis lactogenesis.For rheumatalgia, enteritis, dysentery, urinary tract infection, cough with copious phlegm, traumatic injury, spits blood, metrorrhagia, galactostasis; Fracture is controlled in external, traumatic hemorrhage.
3. Radix Berberidis soulieanae: [nature and flavor] are bitter, cold.[function cures mainly] heat clearing and inflammation relieving, reducing swelling and alleviating pain.
4. Herba malachii aquatici: [nature and flavor] acid is flat.[function cures mainly] clearing away heat and cooling blood, reducing swelling and alleviating pain, removing food stagnancy lactogenesis." Shaanxi Chinese herbal medicine ": heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.
5. Radix Camptandrae Yunnanensis: [nature and flavor] are pungent, temperature.[function cures mainly] promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.For traumatic injury, rheumatic ostalgia, hematemesis and epistaxis, menorrhagia; Worm venom is controlled in external, traumatic hemorrhage.
6. Rhizoma Acori Graminei: [nature and flavor] are pungent, bitter, temperature.[return through] GUIXIN, stomach warp.[function cures mainly] has one's ideas straightened out, and eliminating phlegm is regulated the flow of vital energy, and invigorates blood circulation, and loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.
7. yellow mushroom: [nature and flavor] are micro-salty; Warm in nature.[function cures mainly] chases after wind, cold expelling, and relaxing muscles and tendons is active.Can control lumbago and skelalgia, numb hand and foot, muscles and bones is not relaxed, tic of the limbs.
8. joint joint tea: [nature and flavor] are pungent; Micro-hardship; Temperature.[function cures mainly] expelling wind and cold; Dredge the meridian passage; Hemostasis.Main anemofrigid cold; Headache; Rheumatic arthralgia; Numb limbs and tense tendons; Damaged bone is analysed; Puerperal hemorrhage.
9. Radix cocculi laurifolii: [nature and flavor] are bitter; Pungent; Cold.[return through] bladder; Kidney; Spleen; Lung meridian.[function cures mainly] expelling wind and removing dampness; Dredge the meridian passage; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Edema; Urine leaching pain; Amenorrhea; Traumatic injury; Laryngopharynx swelling and pain; Sore swollen toxin; Eczema; Venom.
10. Pheretima: [nature and flavor] salty in the mouth; Cold in nature.[return through] returns liver; Spleen; Urinary bladder channel.[function cures mainly] clear gesture relieving convulsion; Suppressing the hyperactive liver to relieve the wind syndrome; Dredge the meridian passage; To relieving asthma diuresis.Main calentura heating is mad dry; Infantile convulsion is twitched; Headache due to hyperactivity of liver-YANG; Apoplectic hemiplegia; Rheumatic arthralgia; Dyspnea and cough due to lung-heat; Urinary obstruction
11. Flos Osmanthi Fragrantis roots: [function cures mainly] wind-damp dispelling, cold expelling, repercussive blood, for rheumatism bones and muscles pain, lumbago, toothache of suffering from a deficiency of the kidney.
12. Radix achyranthis asperae (Herba Achyranthis Asperae)s: [function cures mainly] diuresis, purifies the blood, sterilization.Control red-white dysentery, larynx disease, traumatic injury, strengthening bone and muscle, loose blood, pain relieving.
13. Radix Lamiophlomidis Rotataes: [function cures mainly] blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.For traumatic injury, fracture, lumbar strain.
14. Herba Renantherae coccineaes: [nature and flavor] are bitter; Pungent; Flat [function cures mainly] expelling wind and removing dampness; Blood circulation promoting and blood stasis dispelling.Main air pain of dampness syndrome; Fracture.
15. pyrolusitums: [nature and flavor] become, sweet, flat.[function cures mainly] promoting blood circulation and hemostasis, subduing swelling and relieving pain.For traumatic injury, swollen ulcer drug, wound hemorrhage.
16. Radix Salicis Purpureaes: [nature and flavor] are bitter; Property flat [function cures mainly] removing toxic substances; Subduing swelling and relieving pain.Main acute mastitis; Incised wound.
17. Radix seu Caulis Acanthi Ilicifoliis: [nature and flavor] are lightly seasoned, [function cures mainly] cold in nature detumescence dissipating blood stasis, expectorant pain relieving.Treating acute and chronic hepatitis, hepatosplenomegaly, beautiful jade fawns on enlargement, stomachache, asthma.
18. Herba Lycopodii Obscuris: [nature and flavor] are pungent, tepor.[function cures mainly] dispelling wind and removing obstruction in the collateral.Cure mainly rheumatalgia, numb limbs and tense tendons, the disease such as osteopatia sprain and curled paralysis.
19. Radix fici pandurataies: [nature and flavor] are sweet, temperature.[function cures mainly] promoting flow of QI and blood, relaxing muscles and tendons and activating QI and blood in the collateral.For menoxenia, galactostasis, traumatic injury, lumbago pain; Mastitis are controlled in external.
20. Lignum Pini Nodis: [nature and flavor] are bitter; [function cures mainly] warm in nature dispels the wind, dampness, relaxing muscles and tendons, dredging collateral.Control severe and migratory arthralgia pain, convulsion contraction is anxious, and beriberi flaccidity is soft, the arthroncus of knee, falls damage blood stasis.
21. Folium Sapii: [nature and flavor] are bitter, tepor [function cures mainly] removing water retention by purgation; Detumescence dissipating blood stasis; Removing toxic substances parasite killing.Control carbuncle furuncle.
The invention has the beneficial effects as follows:
First, the present invention is selected have expelling wind and removing dampness, blood circulation invigorating efficacies Lysimachia trientaloides Hemsl., determine grass roots, Rhizoma Acori Graminei, there is the Radix Berberidis soulieanae of reducing swelling and alleviating pain effect, Herba malachii aquatici, Radix Camptandrae Yunnanensis, there is dredge the meridian passage, the yellow mushroom of wind-expelling and cold-expelling efficacy, joint joint tea, Radix cocculi laurifolii, Pheretima, Flos Osmanthi Fragrantis root, these are all form according to the strict compatibility of the pharmacologically active of each herbal medicine, determined curative effect;
Second, the present invention selects menthol, bromelain, hyaluronic acid as adjuvant, wherein menthol can chafe teleneuron sensor, slowly can penetrate Intradermal, cause long hyperemia, and reflexive causes deep vessels to change, adjustment vascular function, promote drug effect, menthol also has antiinflammatory, analgesic effect; Bromelain has the potentiality activating inflammatory reaction, and promote drug absorption, bromelain effectively can also treat inflammation in various tissue, comprises thrombophlebitis, Skeletal muscle injury, hematoma, stomatitis, diabetes patient's ulcer and athletic injury etc.; Hyaluronic acid can treatment of arthritis and accelerating wound healing; So these adjuvants can make medicine of the present invention a lot, further Shorten the Treatment Process more rapid-action than other drug, healing acceleration.
3rd, medicine of the present invention is prepared into fumigation and washing agent, impels local organization vasodilation by the thermodynamic activity of fumigation and wash method, blood flow accelerate, make local circulation be able to effective improvement, also can promote drug effect, and compare other plaster etc. be easy to cleaning, use convenient.
Detailed description of the invention
Embodiment 1:
A kind of fumigation-washing medicine promoting muscle sprain to heal, comprise major ingredient and adjuvant, the raw material composition of wherein said major ingredient and weight portion thereof are: Lysimachia trientaloides Hemsl. 20 parts, determine grass roots 15 parts, Radix Berberidis soulieanae 10 parts, Herba malachii aquatici 12 parts, Radix Camptandrae Yunnanensis 8 parts, Rhizoma Acori Graminei 30 parts, yellow mushroom 12 parts, joint joint tea 30 parts, Radix cocculi laurifolii 14 parts, Pheretima 10 parts, Flos Osmanthi Fragrantis root 6 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 12 parts, Radix Lamiophlomidis Rotatae 21 parts, Herba Renantherae coccineae 10 parts, pyrolusitum 5 parts, Radix Salicis Purpureae 4 parts, Radix seu Caulis Acanthi Ilicifolii 8 parts, Herba Lycopodii Obscuri 16 parts, Radix fici panduratae 2 parts, Lignum Pini Nodi 3 parts, Folium Sapii 3 parts, the constitutive material of described adjuvant and weight portion thereof are: menthol 0.2 part, bromelain 0.01 part, hyaluronic acid 0.1 part, Borneolum Syntheticum 0.4 part, Percutaneous absorption enhancer 0.008 part, antioxidant 0.005 part, suspending agent 0.006 part.
Wherein, described Percutaneous absorption enhancer is selected from one or more the combination in any in Oleum menthae, Oleum Terebinthinae, propylene glycol (PG), Polyethylene Glycol or dimethyl sulfoxide (DMSO).Add Percutaneous absorption enhancer and effectively can promote that medicine infiltrates skin, accelerate drug effect.
Wherein, described antioxidant is eucalyptus oil.Eucalyptus oil can effectively prevent oxidation of drug, inefficacy.
Wherein, described suspending agent is one or more the combination in any in sodium carboxymethyl cellulose, sodium alginate or Cera Flava.Owing to having bromelain and hyaluronic acid in adjuvant, so other adjuvants can not select lipid and acids, in order to avoid interact between medicine, reduce drug effect.
Described a kind of fumigation-washing medicine promoting muscle sprain to heal, is prepared from by following steps:
(1) get the Lysimachia trientaloides Hemsl. of formula ratio, Herba malachii aquatici, Radix Camptandrae Yunnanensis, Flos Osmanthi Fragrantis root, Radix achyranthis asperae (Herba Achyranthis Asperae), Radix Lamiophlomidis Rotatae, Herba Lycopodii Obscuri, be chopped into fritter, add 6 times of water gagings, reflux, extract, 1 time, each 1 hour, collect aqueous extract; Medicinal residues 65% alcoholic solution reflux, extract, 1 time, add 8 times amount ethanol at every turn, extraction time is 1.5 hours, merge extractive liquid, reclaims ethanol, obtain alcohol extract, mix with above-mentioned aqueous extract, filter with inorganic ceramic film, the rate of filtration is 9 ~ 13L/h, collects filtrate, stand-by;
(2) that gets formula ratio determines grass roots, Radix Berberidis soulieanae, Rhizoma Acori Graminei, yellow mushroom, Pheretima, Herba Renantherae coccineae, Radix Salicis Purpureae, Radix fici panduratae, Folium Sapii, clean up respectively, use high temperature heat pump seasoning, temperature controls at 40 DEG C, and relative humidity controls 20%, dries to water content lower than 15%, repeatedly ground 200 mesh sieves into powder, merge, obtain mixing fine powders, stand-by;
(3) get the fresh joint joint tea of formula ratio, Radix cocculi laurifolii, pyrolusitum, Radix seu Caulis Acanthi Ilicifolii, the clean chopping of Lignum Pini Nodi, with the alcohol in high concentration dipping 12h of 15 times amount, reclaim ethanol, obtain ethanol lixiviating solution, stand-by; Its concentration of described alcohol in high concentration is 85%, polar organic matter is soluble in polar solvent, Organic substance is generally more soluble in organic solvent, effective ingredient in Chinese herbal medicine is generally polar organic matter, comparatively be soluble in ethanol, so be easy to the effective ingredient of said herbal medicine to extract with alcohol in high concentration;
(4) merged by the extract liquid that above-mentioned steps (1) and (3) obtain, the ratio in 1: 1 adds pure water mixing, precipitates with lime cream, removes impurity, obtains pure medicinal liquid, stand-by; Bromelain is a kind of bioactive substance, be subject to suppression and the destruction of heavy metal ion (Fe2+, Cu2+, Hg+, Pb+ etc.) and oxidant, and calcium ion can be combined into calcium chelate, calcium precipitation with the effective ingredient in medicinal liquid and impurity in lime cream, effective heavy-metal ion removal;
(5) medicinal liquid of mixing fine powders obtained for step (2) and step (4) is merged, be heated to 80 ~ 100 DEG C, add proper amount of active carbon, adjust pH to 6.8, be cooled to 25 DEG C, filter, adjuvant menthol is added successively by formula ratio, Borneolum Syntheticum, Percutaneous absorption enhancer, antioxidant, suspending agent, limit edged stirs in the same direction, add deionized water again and reach 20% to active constituent content, instantaneous ultrahigh-temperature sterilization is carried out with UHT high-temperature short-time sterilization machine, instantaneous ultrahigh-temperature sterilization method sterilization effect is good, the activity of the bromelain added can be effectively avoided to be affected below, add hyaluronic acid again, bromelain, cold preservation, pressurize subpackage under the pressure of 1.2Mpa, obtain the fumigation-washing medicine of promotion muscle sprain of the present invention healing.
Embodiment 2:
A kind of fumigation-washing medicine promoting muscle sprain to heal, comprise major ingredient and adjuvant, the raw material composition of wherein said major ingredient and weight portion thereof are: Lysimachia trientaloides Hemsl. 35 parts, determine grass roots 25 parts, Radix Berberidis soulieanae 20 parts, Herba malachii aquatici 26 parts, Radix Camptandrae Yunnanensis 14 parts, Rhizoma Acori Graminei 45 parts, yellow mushroom 15 parts, joint joint tea 45 parts, Radix cocculi laurifolii 22 parts, Pheretima 15 parts, Flos Osmanthi Fragrantis root 12 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 23 parts, Radix Lamiophlomidis Rotatae 28 parts, Herba Renantherae coccineae 19 parts, pyrolusitum 15 parts, Radix Salicis Purpureae 7 parts, Radix seu Caulis Acanthi Ilicifolii 19 parts, Herba Lycopodii Obscuri 28 parts, Radix fici panduratae 6 parts, Lignum Pini Nodi 5.5 parts, Folium Sapii 9 parts, the constitutive material of described adjuvant and weight portion thereof are: menthol 0.35 part, bromelain 0.015 part, hyaluronic acid 0.2 part, Borneolum Syntheticum 0.5 part, Percutaneous absorption enhancer 0.01 part, antioxidant 0.0075 part, suspending agent 0.01 part.
Wherein, described Percutaneous absorption enhancer is selected from one or more the combination in any in Oleum menthae, Oleum Terebinthinae, propylene glycol (PG), Polyethylene Glycol or dimethyl sulfoxide (DMSO).Add Percutaneous absorption enhancer and effectively can promote that medicine infiltrates skin, accelerate drug effect.
Wherein, described antioxidant is eucalyptus oil.Eucalyptus oil can effectively prevent oxidation of drug, inefficacy.
Wherein, described suspending agent is one or more the combination in any in sodium carboxymethyl cellulose, sodium alginate or Cera Flava.Owing to having bromelain and hyaluronic acid in adjuvant, so other adjuvants can not select lipid and acids, in order to avoid interact between medicine, reduce drug effect.
Described a kind of fumigation-washing medicine promoting muscle sprain to heal, is prepared from by following steps:
(1) get the Lysimachia trientaloides Hemsl. of formula ratio, Herba malachii aquatici, Radix Camptandrae Yunnanensis, Flos Osmanthi Fragrantis root, Radix achyranthis asperae (Herba Achyranthis Asperae), Radix Lamiophlomidis Rotatae, Herba Lycopodii Obscuri, be chopped into fritter, add 7 times of water gagings, reflux, extract, 2 times, each 1.5 hours, collect aqueous extract; Medicinal residues 70% alcoholic solution reflux, extract, 2 times, add 9 times amount ethanol at every turn, extraction time is 2 hours, merge extractive liquid, reclaims ethanol, obtain alcohol extract, mix with above-mentioned aqueous extract, filter with inorganic ceramic film, the rate of filtration is 11L/h, collects filtrate, stand-by;
(2) that gets formula ratio determines grass roots, Radix Berberidis soulieanae, Rhizoma Acori Graminei, yellow mushroom, Pheretima, Herba Renantherae coccineae, Radix Salicis Purpureae, Radix fici panduratae, Folium Sapii, clean up respectively, use high temperature heat pump seasoning, temperature controls at 55 DEG C, and relative humidity controls 30%, dries to water content lower than 15%, repeatedly ground 210 mesh sieves into powder, merge, obtain mixing fine powders, stand-by;
(3) get the fresh joint joint tea of formula ratio, Radix cocculi laurifolii, pyrolusitum, Radix seu Caulis Acanthi Ilicifolii, the clean chopping of Lignum Pini Nodi, with the alcohol in high concentration dipping 18h of 16.5 times amount, reclaim ethanol, obtain ethanol lixiviating solution, stand-by; Its concentration of described alcohol in high concentration is 87.5%, polar organic matter is soluble in polar solvent, Organic substance is generally more soluble in organic solvent, effective ingredient in Chinese herbal medicine is generally polar organic matter, comparatively be soluble in ethanol, so be easy to the effective ingredient of said herbal medicine to extract with alcohol in high concentration;
(4) merged by the extract liquid that above-mentioned steps (1) and (3) obtain, the ratio in 1: 1 adds pure water mixing, precipitates with lime cream, removes impurity, obtains pure medicinal liquid, stand-by; Bromelain is a kind of bioactive substance, be subject to suppression and the destruction of heavy metal ion (Fe2+, Cu2+, Hg+, Pb+ etc.) and oxidant, and calcium ion can be combined into calcium chelate, calcium precipitation with the effective ingredient in medicinal liquid and impurity in lime cream, effective heavy-metal ion removal;
(5) medicinal liquid of mixing fine powders obtained for step (2) and step (4) is merged, be heated to 90 DEG C, add proper amount of active carbon, adjust pH to 7.0, be cooled to 30 DEG C, filter, adjuvant menthol is added successively by formula ratio, Borneolum Syntheticum, Percutaneous absorption enhancer, antioxidant, suspending agent, limit edged stirs in the same direction, add deionized water again and reach 22.5% to active constituent content, instantaneous ultrahigh-temperature sterilization is carried out with UHT high-temperature short-time sterilization machine, instantaneous ultrahigh-temperature sterilization method sterilization effect is good, the activity of the bromelain added can be effectively avoided to be affected below, add hyaluronic acid again, bromelain, cold preservation, pressurize subpackage under the pressure of 1.225Mpa, obtain the fumigation-washing medicine of promotion muscle sprain of the present invention healing.
Embodiment 3:
A kind of fumigation-washing medicine promoting muscle sprain to heal, comprise major ingredient and adjuvant, the raw material composition of wherein said major ingredient and weight portion thereof are: Lysimachia trientaloides Hemsl. 50 parts, determine grass roots 35 parts, Radix Berberidis soulieanae 30 parts, Herba malachii aquatici 40 parts, Radix Camptandrae Yunnanensis 20 parts, Rhizoma Acori Graminei 60 parts, yellow mushroom 18 parts, joint joint tea 60 parts, Radix cocculi laurifolii 30 parts, Pheretima 20 parts, Flos Osmanthi Fragrantis root 18 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 34 parts, Radix Lamiophlomidis Rotatae 35 parts, Herba Renantherae coccineae 28 parts, pyrolusitum 25 parts, Radix Salicis Purpureae 10 parts, Radix seu Caulis Acanthi Ilicifolii 30 parts, Herba Lycopodii Obscuri 40 parts, Radix fici panduratae 10 parts, Lignum Pini Nodi 8 parts, Folium Sapii 15 parts, the constitutive material of described adjuvant and weight portion thereof are: menthol 0.5 part, bromelain 0.02 part, hyaluronic acid 0.3 part, Borneolum Syntheticum 0.6 part, Percutaneous absorption enhancer 0.012 part, antioxidant 0.01 part, suspending agent 0.014 part.
Wherein, described Percutaneous absorption enhancer is selected from one or more the combination in any in Oleum menthae, Oleum Terebinthinae, propylene glycol (PG), Polyethylene Glycol or dimethyl sulfoxide (DMS0).Add Percutaneous absorption enhancer and effectively can promote that medicine infiltrates skin, accelerate drug effect.
Wherein, described antioxidant is eucalyptus oil.Eucalyptus oil can effectively prevent oxidation of drug, inefficacy.
Wherein, described suspending agent is one or more the combination in any in sodium carboxymethyl cellulose, sodium alginate or Cera Flava.Owing to having bromelain and hyaluronic acid in adjuvant, so other adjuvants can not select lipid and acids, in order to avoid interact between medicine, reduce drug effect.
Described a kind of fumigation-washing medicine promoting muscle sprain to heal, is prepared from by following steps:
(1) get the Lysimachia trientaloides Hemsl. of formula ratio, Herba malachii aquatici, Radix Camptandrae Yunnanensis, Flos Osmanthi Fragrantis root, Radix achyranthis asperae (Herba Achyranthis Asperae), Radix Lamiophlomidis Rotatae, Herba Lycopodii Obscuri, be chopped into fritter, add 8 times of water gagings, reflux, extract, 3 times, each 2 hours, collect aqueous extract; Medicinal residues 75% alcoholic solution reflux, extract, 3 times, add 10 times amount ethanol at every turn, extraction time is 2.5 hours, merge extractive liquid, reclaims ethanol, obtain alcohol extract, mix with above-mentioned aqueous extract, filter with inorganic ceramic film, the rate of filtration is 13L/h, collects filtrate, stand-by;
(2) that gets formula ratio determines grass roots, Radix Berberidis soulieanae, Rhizoma Acori Graminei, yellow mushroom, Pheretima, Herba Renantherae coccineae, Radix Salicis Purpureae, Radix fici panduratae, Folium Sapii, clean up respectively, use high temperature heat pump seasoning, temperature controls at 70 DEG C, and relative humidity controls 40%, dries to water content lower than 15%, repeatedly ground 220 mesh sieves into powder, merge, obtain mixing fine powders, stand-by;
(3) get the fresh joint joint tea of formula ratio, Radix cocculi laurifolii, pyrolusitum, Radix seu Caulis Acanthi Ilicifolii, the clean chopping of Lignum Pini Nodi, with the alcohol in high concentration dipping 24h of 18 times amount, reclaim ethanol, obtain ethanol lixiviating solution, stand-by; Its concentration of described alcohol in high concentration is 90%, polar organic matter is soluble in polar solvent, Organic substance is generally more soluble in organic solvent, effective ingredient in Chinese herbal medicine is generally polar organic matter, comparatively be soluble in ethanol, so be easy to the effective ingredient of said herbal medicine to extract with alcohol in high concentration;
(4) merged by the extract liquid that above-mentioned steps (1) and (3) obtain, the ratio in 1: 1 adds pure water mixing, precipitates with lime cream, removes impurity, obtains pure medicinal liquid, stand-by; Bromelain is a kind of bioactive substance, be subject to suppression and the destruction of heavy metal ion (Fe2+, Cu2+, Hg+, Pb+ etc.) and oxidant, and calcium ion can be combined into calcium chelate, calcium precipitation with the effective ingredient in medicinal liquid and impurity in lime cream, effective heavy-metal ion removal;
(5) medicinal liquid of mixing fine powders obtained for step (2) and step (4) is merged, be heated to 100 DEG C, add proper amount of active carbon, adjust pH to 7.2, be cooled to 35 DEG C, filter, adjuvant menthol is added successively by formula ratio, Borneolum Syntheticum, Percutaneous absorption enhancer, antioxidant, suspending agent, limit edged stirs in the same direction, add deionized water again and reach 25% to active constituent content, instantaneous ultrahigh-temperature sterilization is carried out with UHT high-temperature short-time sterilization machine, instantaneous ultrahigh-temperature sterilization method sterilization effect is good, the activity of the bromelain added can be effectively avoided to be affected below, add hyaluronic acid again, bromelain, cold preservation, pressurize subpackage under the pressure of 1.25Mpa, obtain the fumigation-washing medicine of promotion muscle sprain of the present invention healing.
Clinical experiment and treatment data:
One, the long term toxicity test of a kind of fumigation-washing medicine promoting muscle sprain to heal of the present invention.
Be toxicity test object with healthy calf, get healthy calf 20 points of experimental grouies and matched group, often organize each 10, matched group compares with vaseline.Test group uses medicine of the present invention.
Test method: hair is shaved the position of light area 5cm2 size as test portion in its strand of inside skin by 20 healthy calf, removes clean.
Matched group: be coated with once with vaseline every day in 10 healthy calf test portions, be coated with 30 days continuously, observation calf situation is normal.
Test group: by 10 healthy calf test portion every days with medicine fumigation and wash method secondary of the present invention, sooner or later each once, continuous 30 days, observe rabbit without exception, illustrate that medicine of the present invention has no side effect to healthy calf.
Two, a kind of fumigation-washing medicine test of pesticide effectiveness promoting muscle sprain to heal of the present invention.
The fumigation-washing medicine using real the present invention to execute promotion muscle sprain healing prepared by example 1 ~ 3 carries out clinical treatment and observe the curative effect.
1, clinical data: clinical muscle sprain patient 860 example of accepting for medical treatment of random selecting in March, 2012 to 2014 year JIUYUE, be divided into two groups at random, often organize 430 people, a group as a control group, and another group is as laboratory observation group.
2, Therapeutic Method: the peaceful cream of the pain of injury that the every order of experimental group uses Beijing Ling Rui hygienic material company limited of hospital to produce, by specification method uses, experimental group every day twice, divide fumigation and wash method muscle sprain position sooner or later, each consumption 3 grams, within 5 days, be a course for the treatment of, a general course for the treatment of can cure, and then continues a course for the treatment of of use if cure.
3, criterion of therapeutical effect:
Recovery from illness: pain symptom, sign disappear completely; Effective: pain symptom, sign disappear substantially; Take a turn for the better: pain symptom obviously alleviates, but still has mild pain after fatigue; Invalid: pain symptom, sign are without alleviation.
4. therapeutic outcome statistics:
Table one: one the course for the treatment of Cure statistical table
One the course for the treatment of data Case load Recovery from illness Effective Take a turn for the better Invalid Total effective rate/%
Matched group 430 165 154 60 51 88.139
Experimental group 430 298 102 19 11 97.442
Table two: two the course for the treatment of Cure statistical table
One the course for the treatment of data Case load Recovery from illness Effective Take a turn for the better Invalid Total effective rate/%
Matched group 430 201 128 56 45 89.535
Experimental group 430 379 28 16 7 98.372
From above toxicity test and clinical treatment data, a kind of fumigation-washing medicine promoting muscle sprain to heal of the present invention has no side effect, the clinical treatment effective percentage of a course for the treatment of reaches 97.442%, and the clinical treatment effective percentage of two courses for the treatment of reaches 98.372%, evident in efficacy and healing period is short.
Three, clinical model case:
Patient one: beam so-and-so, man, 21 years old, certain school student, when playing basketball, leg muscle is pulled, and has an intense pain, treat in Hospital, within two weeks, do not feel any better, then use medicine of the present invention to carry out fumigation in treating, every day, sooner or later respectively once each 5 grams 5 days was 1 course for the treatment of, through 1 course of therapy, the pain symptom of patient disappears completely, and walk normal, activity freely.
Patient two: pay so-and-so, female, student, 13 years old, when having physical education, arm was seriously sprained, and can touch the rope strip lump of muscular tone formation with hands, touch pain obviously, local swelling.Cleaned by injury ethanol, then use medicine of the present invention to carry out fumigation in treating, every day is sooner or later each, and once each 5 grams, within 5 days, be 1 course for the treatment of, through 1 course of therapy, the pain symptom of patient disappears completely, and walk normal, activity freely.
Patient three: grandson so-and-so, man, 52 years old, rural migrant worker, overexert during working and cause psoas muscle to be pulled, buy medicine in pharmacy voluntarily and treat, a wheat harvesting period has no improvement, year removes hospital therapy, and through using medicine of the present invention to carry out fumigation in treating, every day sooner or later respectively once, each 5 grams 5 days is 1 course for the treatment of, after the course for the treatment of, symptom is clearly better, and pain disappears, after two courses for the treatment of, basic healing, the later stage does not recur again, on work without any impact.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.

Claims (9)

1. promote the fumigation-washing medicine that muscle sprain heals, it is characterized in that comprising major ingredient and adjuvant, the raw material composition of wherein said major ingredient and weight portion thereof are: Lysimachia trientaloides Hemsl. 20 ~ 50 parts, determine grass roots 15 ~ 35 parts, Radix Berberidis soulieanae 10 ~ 30 parts, Herba malachii aquatici 12 ~ 40 parts, Radix Camptandrae Yunnanensis 8 ~ 20 parts, Rhizoma Acori Graminei 30 ~ 60 parts, yellow mushroom 12 ~ 18 parts, joint joint tea 30 ~ 60 parts, Radix cocculi laurifolii 14 ~ 30 parts, Pheretima 10 ~ 20 parts, Flos Osmanthi Fragrantis root 6 ~ 18 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 12 ~ 34 parts, Radix Lamiophlomidis Rotatae 21 ~ 35 parts, Herba Renantherae coccineae 10 ~ 28 parts, pyrolusitum 5 ~ 25 parts, Radix Salicis Purpureae 4 ~ 10 parts, Radix seu Caulis Acanthi Ilicifolii 8 ~ 30 parts, Herba Lycopodii Obscuri 16 ~ 40 parts, Radix fici panduratae 2 ~ 10 parts, Lignum Pini Nodi 3 ~ 8 parts, Folium Sapii 3 ~ 15 parts, the constitutive material of described adjuvant and weight portion thereof are: menthol 0.2 ~ 0.5 part, bromelain 0.01 ~ 0.02 part, hyaluronic acid 0.1 ~ 0.3 part, Borneolum Syntheticum 0.4 ~ 0.6 part, Percutaneous absorption enhancer 0.008 ~ 0.012 part, antioxidant 0.005 ~ 0.01 part, suspending agent 0.006 ~ 0.014 part.
2. a kind of fumigation-washing medicine promoting muscle sprain to heal as claimed in claim 1, is characterized in that described Percutaneous absorption enhancer is selected from one or more the combination in any in Oleum menthae, Oleum Terebinthinae, propylene glycol (PG), Polyethylene Glycol or dimethyl sulfoxide (DMSO).
3. a kind of fumigation-washing medicine promoting muscle sprain to heal as claimed in claim 1, is characterized in that described antioxidant is eucalyptus oil.
4. a kind of fumigation-washing medicine promoting muscle sprain to heal as claimed in claim 1, is characterized in that described suspending agent is one or more the combination in any in sodium carboxymethyl cellulose, sodium alginate or Cera Flava.
5. a kind of fumigation-washing medicine promoting muscle sprain to heal as described in Claims 1 to 4, it is characterized in that being prepared from by following steps:
(1) get the Lysimachia trientaloides Hemsl. of formula ratio, Herba malachii aquatici, Radix Camptandrae Yunnanensis, Flos Osmanthi Fragrantis root, Radix achyranthis asperae (Herba Achyranthis Asperae), Radix Lamiophlomidis Rotatae, Herba Lycopodii Obscuri, be chopped into fritter, add 6 ~ 8 times of water gagings, reflux, extract, 1 ~ 3 time, each 1 ~ 2 hour, collect aqueous extract; Medicinal residues 65% ~ 75% alcoholic solution reflux, extract, 1 ~ 3 time, add 8 ~ 10 times amount ethanol at every turn, extraction time is 1.5 ~ 2.5 hours, merge extractive liquid, reclaims ethanol, obtains alcohol extract, mix with above-mentioned aqueous extract, filters, and collects filtrate, stand-by;
(2) that gets formula ratio determines grass roots, Radix Berberidis soulieanae, Rhizoma Acori Graminei, yellow mushroom, Pheretima, Herba Renantherae coccineae, Radix Salicis Purpureae, Radix fici panduratae, Folium Sapii, cleans up respectively, dries, repeatedly grinds 200 ~ 220 mesh sieves into powder, merges, obtains mixing fine powders, stand-by;
(3) get the fresh joint joint tea of formula ratio, Radix cocculi laurifolii, pyrolusitum, Radix seu Caulis Acanthi Ilicifolii, the clean chopping of Lignum Pini Nodi, with the alcohol in high concentration dipping 12 ~ 24h of 15 ~ 18 times amount, reclaim ethanol, obtain ethanol lixiviating solution, stand-by;
(4) merged by the extract liquid that above-mentioned steps (1) and (3) obtain, the ratio in 1: 1 adds pure water mixing, precipitates with lime cream, removes impurity, obtains pure medicinal liquid, stand-by;
(5) medicinal liquid of mixing fine powders obtained for step (2) and step (4) is merged, be heated to 80 ~ 100 DEG C, add proper amount of active carbon, adjust pH to 6.8 ~ 7.2, be cooled to 25 ~ 35 DEG C, filter, adjuvant menthol, Borneolum Syntheticum, Percutaneous absorption enhancer, antioxidant, suspending agent is added successively by formula ratio, limit edged stirs in the same direction, then adds deionized water and reach 20 ~ 25% to active constituent content, sterilizing, add hyaluronic acid, bromelain again, cold preservation, pressurization subpackage, obtains the fumigation-washing medicine of promotion muscle sprain of the present invention healing.
6. a kind of fumigation-washing medicine promoting muscle sprain to heal as claimed in claim 5, it is characterized in that in described preparation process (2), high temperature heat pump seasoning is used in the oven dry of medical material, temperature controls at 40 ~ 70 DEG C, relative humidity controls 20 ~ 40%, dries to water content described medical material lower than 15%.
7. a kind of fumigation-washing medicine promoting muscle sprain to heal as claimed in claim 5, is characterized in that, in described preparation process (3), its concentration of described alcohol in high concentration is 85 ~ 90%.
8. a kind of fumigation-washing medicine promoting muscle sprain to heal as claimed in claim 5, it is characterized in that, in described preparation process (5), described sterilizing methods is high-temperature short-time sterilization, device therefor is UHT high-temperature short-time sterilization machine.
9. a kind of fumigation-washing medicine promoting muscle sprain to heal as claimed in claim 5, is characterized in that, in described preparation process (5), pressure during described pressurization subpackage is 1.2 ~ 1.25Mpa.
CN201410827702.7A 2014-12-29 2014-12-29 Fuming and washing medicine for promoting healing of pulled muscles Pending CN104491641A (en)

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