CN103690800A - Pregnancy vulvareczema nursing powder and preparation method thereof - Google Patents
Pregnancy vulvareczema nursing powder and preparation method thereof Download PDFInfo
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Abstract
The invention discloses pregnancy vulvareczema nursing powder and a preparation method thereof, and aims to realize nursing of pregnancy vulvareczema. The preparation method is characterized by comprising the following steps: (1) extracting volatile oil from tall gastrodia fruit, shiny-leaved birch bark coarse powder, stir-fried green bean coarse powder, poncirus bark coarse powder and fistular onion stalk for later use; (2) smashing oxhide gelatin into fine powder for later use; (3) performing water extraction and alcohol precipitation on Yunnan bulbophyllum herb, unpleasant swallowwort herb, towel gourd vegetable sponge, Chinese mosla herb, sea grass, wild buckwheat rhizome stem and leaf and decoction dregs obtained in the step 1, extracting centrifugate, concentrating and performing spray drying to obtain a primary material; (4) spraying the volatile oil obtained in the step (1) into the primary material obtained in the step (3), adding oxhide gelatin fine powder obtained in the step (2), mixing uniformly, sieving with a 100-mesh sieve, sterilizing and performing split charging. As proved by clinical experiments, the powder is suitable for treating pregnancy vulvareczema, has the characteristics of good curative effect and high safety, and is worth of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to pregnancy period vulval eczema nursing and fall apart and preparation method thereof.
Background technology
Vulval eczema is a kind of common non-infectious dermatosis; pathological changes is confined to perineum and clitoris more, also even have spread to buttocks, can there is erythema, erythema, erosion in part; ooze out, incrustation, desquamation; the course of disease is long, and perineum surrounding skin often thickens, and color is greyish white or dark red; coarse; so that chap, ooze out, pruritus, repeatedly to show effect be main feature, any age all can fall ill.Pathogenesis, vulval eczema is mainly a kind of delayed allergy that the inside and outside motivating factor by complexity causes.But its cause of disease and allergenic character, immunoreactive feature and whether relevant with the late response of IgE mediation, illustrate not yet completely.
Pregnancy period hormone in vivo level produces great variety, local nerve function sensitive improves thereupon, it is clearly relevant to vulval eczema generation that Weidner etc. have confirmed that local nerve function sensitive improves, its inherent approach is: nerve fiber and mastocyte are contacted directly by Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, can make mast cell degranulation releasing histamine, cause pruritus.So be different from other allergic eczemas, even if pregnancy period eczema is removed some sensitizing factor, eczema pathological changes can not disappear very soon, so existing eczema treatment means are for pregnancy period vulval eczema effect unsatisfactory.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides the nursing sure and the meeting vaginal eczema that side effect is little of a kind of curative effect to fall apart and preparation method thereof.
The technical scheme that the present invention solves its technical problem is: a kind of nursing for pregnancy period vulval eczema is loose, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Herba Bulbophylli inconspicui, 6 ~ 12 parts of Radix Tylophorae arenicolaes, 3 ~ 10 parts of Retinervus Luffae Fructuss, alizarin 6 ~ 12 parts of sea, 3 ~ 10 parts of Herba Moslaes, 6 ~ 12 parts of gelatinum oxhide, go back 6 ~ 12 parts, bobbin, 6 ~ 12 parts of Cortex Ponciri trifoliatae, 6 ~ 12 parts of stir-fried kidney beans, 1 ~ 5 part of Cortex Betulae Luminiferae, 3 ~ 10 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 10 ~ 25 parts of Bulbus Allii Fistulosi.
Chinese medicine of the present invention can be prepared from by following method:
(1) will go back bobbin, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Cortex Ponciri trifoliatae coarse powder, Bulbus Allii Fistulosi and with vapor distillation, extract volatile oil respectively, and mixing for standby use after collecting, the medicinal residues after extraction are standby after mixing;
(2) gelatinum oxhide, stir-fried kidney beans were pulverized respectively to 150 mesh sieves, became fine powder mixing for standby use;
(3) gained medicinal residues in Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae, Retinervus Luffae Fructus, Hai Qian, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray was dry, obtains just material;
(4) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, add gained mixing fine powders in step 2 to mix, cross 100 mesh sieves, sterilizing subpackage forms.
Wherein said: Herba Bulbophylli inconspicui, for the orchid family Bulbophyllum platymiscium Herba Bulbophylli inconspicui Bulbophyllum inconspicuum Maxim., with all herbal medicine.Nature and flavor are sweet; Pungent; Cool; Nontoxic.Return lung; Stomach warp.Merit can heat clearing away YIN nourishing; Nourishing the lung to arrest cough.
Radix Tylophorae arenicolae is the spirit of asclepiadaceae plant bamboo disappear root or the aerial parts of Cynanchum inamoenum (Maxim.) Loes..Nature and flavor are bitter; Micro-pungent; Property is put down.Return lung meridian.Merit can the kidney invigorating, spleen invigorating, removing toxic substances.
Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.Merit can dredging collateral, invigorates blood circulation, and dispels the wind.
Hai Qian is Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Heng Shi Alga Sgrgassi Enerves Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri(Turn.) frond of C. Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Merit can hard masses softening and resolving; Removing heat-phlegm.
Herba Moslae is the dry aerial parts of labiate Mosla chinensis Maxim..Nature and flavor are pungent, tepor.Attach to the lung and stomach meridians.Merit can relieving the exterior syndrome by diaphoresis, and middle dampness removing.
Gelatinum oxhide, the glue of making for the gelatinum oxhide skin that is bovid cattle Bos taurus domesticus Gmelin.Sweet in the mouth; Property is put down.Return lung; Large intestine channel.Merit can be nourshing Yin and drynsessmoistening prescription; Nourishing blood and hemoslasis; Promoting blood circulation and detumescence; Removing toxic substances.
Also bobbin, is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.Main dizzy; Pupil; Wind syndrome of head headache; Weak breath consumption of essence; Early whitening of beard and hair.
Cortex Ponciri trifoliatae is bark bits or the peel bits of rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus tuifoliata (L.) Raf..Nature and flavor are pungent; Temperature.Return liver; Kidney channel.Merit can endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.
Stir-fried kidney beans, is the dry mature seed of pulse family Dolichos plant Seem Lablab Album, fries to micro-yellow, and the used time smashs to pieces.Nature and flavor are sweet, tepor.Return spleen, stomach warp.Merit can invigorating the spleen for eliminating dampness, and in relieve summer heat.
Cortex Betulae Luminiferae is Betulaceae betula luminifera Betula luminifera H. Win Flos jasmini. bark.Nature and flavor are sweet; Pungent; Slightly warm in nature.Merit can damp eliminating cold expelling; Disappear stagnant and in, removing toxic substances.
Rhizoma Fagopyri Dibotryis stem and leaf is the stem and leaf of polygonaceae plant Rhizoma Fagopyri Dibotryis Fagopyrum dibotrys (D.Don) Hara.Nature and flavor are bitter, pungent, cool in nature.Return lung, spleen, Liver Channel.Merit can heat-clearing and toxic substances removing, invigorating spleen to remove dampness, dispelling wind and removing obstruction in the collateral.
Bulbus Allii Fistulosi, is the cauloid of Liliaceae allium Herba Alii fistulosi, and merit can be delivered and activate yang, removing toxic substances parasite killing.
Composition principle: vulval eczema, the traditional Chinese medical science thinks that its cause of disease is wind, wet, the pathogenic heat skin of being detained, or wind syndrome due to blood-deficiency dryness-transformation, due to failure of skin and muscle to be nourished.Mostly choose " removing dampness removing toxic substances " medicines such as Rhizoma Smilacis Glabrae, Rhizoma Coptidis, Cortex Phellodendri, Herba Taraxaci, Alumen, Radix Sophorae Flavescentis, Cortex Dictamni, or Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra " blood enriching and dryness moistening " Drug therapy.But pregnancy period vulval eczema is that local nerve function sensitive improves thereupon because pregnancy period hormone in vivo level produces great variety, and then mediation mastocyte forms.And the pregnancy period use dispelling the damp pathogen with drugs of bitter in taste and cold in nature medicine also easily to cause local skin to lose to support atrophy, blood circulation promoting medicine too much can cause the untoward reaction such as local telangiectasis again.Inventor's clinical research finds that pregnancy period local nerve function hypersensitivity is also relevant with the latent network of cold-evil, both can illustrate, Pregnant Women, under cold stimulation, can bring out vulval eczema recurrence.
Compared with prior art, the present invention has following characteristics:
1, prescription is unique: in side, get Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae is monarch, described Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae coordinate, and the two is lung meridian medication, and the main skin of lung, so the two can enter skin network; The feature of Herba Bulbophylli inconspicui is heat clearing away, but nature and flavor are sweet cool; The vulval eczema of outbreak does not also lie in " dampness " repeatedly, so the result of clinical dampness often causes protracted course of disease, and local skin lichenization, dryization, Herba Bulbophylli inconspicui has the merit of sweet profit, simultaneously can YIN nourishing, be suitable for the pregnancy period to use; In rat inflammatory pain model, the Herba Bulbophylli inconspicui water extraction liquid of 1mg/kg can reduce localized heat shock protein (HSP) expresses; Radix Tylophorae arenicolae toil, for rat eczema skin lesion model, the glycoside extract of 1mg/kg is local to be used, and can make local mast cell activity reduce, and then resists local nerve hypersensitive state excitation;
2, in side, getting Herba Moslae is minister, the outer dampness of Herba Moslae solution Intradermal film, and Herba Moslae volatile oil can weaken rabbit local inflammation response strength;
3, getting Retinervus Luffae Fructus promoting blood circulation to remove obstruction in the collateral, Cortex Ponciri trifoliatae eleminating phlegm and freeing channels, extra large alizarin dissipating phlegm and resolving masses is minister, and inventor for many years Clinical and experimental study show, Cortex Ponciri trifoliatae, extra large madder can be alleviated rapidly the high quick pruritus sense of discomfort of bringing of local nerve; Get and go back bobbin tonify deficiency subduing the wind syndrome, gelatinum oxhide is nourshing Yin and drynsessmoistening prescription to nourish blood, auxiliary Radix Tylophorae arenicolae kidney and spleen invigorating;
4, make medication pair: Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, the two heat one is cold, forms medicine pair, jointly reaching the effect of drying and unbiased, and has the effect of removing toxic substances;
5, gelatinum oxhide is rich in colloidality, stir-fried kidney beans rich in starch, and the two local use contributes to alleviate local mucous membrane stimulation;
6, Bulbus Allii Fistulosi merit can be delivered and activate yang, and the effect in we is to increase the whole transdermal absorption factor of medicine;
7, medicine material survival dose of the present invention is groped in a large number to sum up through inventor and is drawn, each crude drug consumption is for all to have good curative effect in following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: 20 parts of Herba Bulbophylli inconspicui, 10 parts of Radix Tylophorae arenicolaes, 6 parts of Retinervus Luffae Fructuss, alizarin 10 parts of sea, 6 parts of Herba Moslaes, 10 parts of gelatinum oxhide, go back 10 parts, bobbin, 10 parts of Cortex Ponciri trifoliatae, 10 parts of stir-fried kidney beans, 2 parts of Cortex Betulae Luminiferaes, 6 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 20 parts of Bulbus Allii Fistulosi.
The preparation method of embodiment 1 is: by Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae, Retinervus Luffae Fructus, Hai Qian, Herba Moslae, gelatinum oxhide, go back bobbin, Cortex Ponciri trifoliatae, stir-fried kidney beans, Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, Bulbus Allii Fistulosi mixing and water adding and decoct, after 30 minutes, get filtrate, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and gets appropriate morning and evening perineum local wet dressing around every day.
Embodiment 2, crude drug weight proportion: 10 parts of Herba Bulbophylli inconspicui, 6 parts of Radix Tylophorae arenicolaes, 3 parts of Retinervus Luffae Fructuss, alizarin 6 parts of sea, 3 parts of Herba Moslaes, 6 parts of gelatinum oxhide, go back 6 parts, bobbin, 6 parts of Cortex Ponciri trifoliatae, 6 parts of stir-fried kidney beans, 1 part of Cortex Betulae Luminiferae, 3 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 10 parts of Bulbus Allii Fistulosi.
Embodiment 3, crude drug weight proportion: 20 parts of Herba Bulbophylli inconspicui, 10 parts of Radix Tylophorae arenicolaes, 6 parts of Retinervus Luffae Fructuss, alizarin 10 parts of sea, 6 parts of Herba Moslaes, 10 parts of gelatinum oxhide, go back 10 parts, bobbin, 10 parts of Cortex Ponciri trifoliatae, 10 parts of stir-fried kidney beans, 2 parts of Cortex Betulae Luminiferaes, 6 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 20 parts of Bulbus Allii Fistulosi.
Embodiment 4, crude drug weight proportion: 30 parts of Herba Bulbophylli inconspicui, 12 parts of Radix Tylophorae arenicolaes, 10 parts of Retinervus Luffae Fructuss, alizarin 12 parts of sea, 10 parts of Herba Moslaes, 12 parts of gelatinum oxhide, go back 12 parts, bobbin, 12 parts of Cortex Ponciri trifoliatae, 12 parts of stir-fried kidney beans, 5 parts of Cortex Betulae Luminiferaes, 10 parts of Rhizoma Fagopyri Dibotryis stem and leaf, 25 parts of Bulbus Allii Fistulosi.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) will go back bobbin, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Cortex Ponciri trifoliatae coarse powder, Bulbus Allii Fistulosi and with vapor distillation, extract volatile oil respectively, and mixing for standby use after collecting, the medicinal residues after extraction are standby after mixing;
(2) gelatinum oxhide, stir-fried kidney beans were pulverized respectively to 150 mesh sieves, became fine powder mixing for standby use;
(3) gained medicinal residues in Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae, Retinervus Luffae Fructus, Hai Qian, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray was dry, obtains just material;
(4) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, add gained mixing fine powders in step 2 to mix, cross 100 mesh sieves, sterilizing subpackage forms.
During use, the hot water of 50 ℃ of left and right tunes to open, and gets every day and spreads in right amount perineum part around.
Effective combination of said medicine, coordinates mutually, effectively reach the object that is applicable to pregnancy period vulval eczema use, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: in June, 2012 ~ 2013 are diagnosed as vulval eczema 133 examples year June, are outpatient, and at 20 ~ 42 years old age, pregnant week is 5 ~ 38 weeks.
1.1.2 diagnostic criteria: the < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > that vulval eczema diagnostic criteria is promulgated by State Administration of Traditional Chinese Medicine carries out.Symptom: perineum humidity, pruritus, twinge discomfort, night more so.Training checks: pimple, erythema, erosion, sepage appear in acute person's perineum place; Chronic person's perineum place skin is canescence, thickens chap, is lichenification and the shallow breach of radial table.
1.1.3 grouping: be divided at random matched group 40 examples, soak group 48 examples, dress group 45 examples.Three groups of cases difference not statistically significant (P>0.05) on age, pregnant week distribute, has comparability.
1.2 method.
1.2.1 Therapeutic Method: 1:1000 potassium permanganate soak for matched group, 2 times/d; Soak group is with local wet dressing around gained decoction perineum in the embodiment of the present invention 1,2 times/d; Dress group and dress after melting with gained medicated powder hot water in the embodiment of the present invention 2,2 times/d.Above case all be take 2 weeks as 1 course for the treatment of, and the course for the treatment of, interval 2d, judged curative effect after 2 courses for the treatment of.
1.2.2 criterion of therapeutical effect: recovery from illness: clinical symptoms, sign disappear; Effective: clinical symptoms, sign turn for the better by and large, vulval eczema scope is dwindled more than 1/2; Effective: clinical symptoms, sign alleviate, vulval eczema scope is dwindled less than 1/2 before treating; Invalid: clinical symptoms, sign, vulval eczema scope are unchanged.
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ
2check.
2 results.
2.1 3 groups of Comprehensive Clinical curative effects comparison: soak group is organized cure rate and extremely obvious (the soak group χ of matched group difference with dressing
2=16.97, P<0.05; Dress group χ
2=14.42, P<0.05), soak group is organized total effective rate apparently higher than matched group (soak group χ with dressing
2=12.46, P<0.001; Dress group χ
2=16.03, P<0.001), see the following form.
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate |
| Matched group | 40 | 2（5.00%） | 13（32.50%） | 9（22.50%） | 16（40.00%） | 60.00% |
| Soak group | 48 | 21（43.75%） | 15（31.25%） | 8（16.67%） | 4（8.33%） | 91.67% |
| Dress group | 45 | 18（40.00%） | 17（37.78%） | 8（17.78%） | 2（4.44%） | 95.56% |
2.2 3 groups of adverse reactions of patients incidence rates comparison: three groups have been obvious adverse reaction report.
3. conclusion.
This result of study shows, soak group of the present invention is organized cure rate, total effective rate apparently higher than matched group with dressing, and the incidence rate of untoward reaction is low, and can reduce relapse rate, illustrate that the present invention has in treatment that untoward reaction is light, the higher advantage of safety aspect pregnancy period vulval eczema.
Claims (1)
1. pregnancy period vulval eczema nursing is loose and preparation method thereof, it is characterized in that, crude drug is: Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae, Retinervus Luffae Fructus, Hai Qian, Herba Moslae, gelatinum oxhide, to go back bobbin, Cortex Ponciri trifoliatae, stir-fried kidney beans, Cortex Betulae Luminiferae, Rhizoma Fagopyri Dibotryis stem and leaf, Herba Alii fistulosi white; By following steps, formed:
(1) will go back bobbin, Cortex Betulae Luminiferae coarse powder, Herba Moslae, Cortex Ponciri trifoliatae coarse powder, Bulbus Allii Fistulosi and with vapor distillation, extract volatile oil respectively, and mixing for standby use after collecting, the medicinal residues after extraction are standby after mixing;
(2) gelatinum oxhide, stir-fried kidney beans were pulverized respectively to 150 mesh sieves, became fine powder mixing for standby use;
(3) gained medicinal residues in Herba Bulbophylli inconspicui, Radix Tylophorae arenicolae, Retinervus Luffae Fructus, Hai Qian, Rhizoma Fagopyri Dibotryis stem and leaf and step 1 are mixed and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, extracting centrifugal liquid concentrated spray was dry, obtains just material;
(4) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, add gained mixing fine powders in step 2 to mix, cross 100 mesh sieves, sterilizing subpackage forms.
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| CN201410013822.3A CN103690800B (en) | 2014-01-13 | 2014-01-13 | Pregnancy period vulval eczema nursing is loose and preparation method thereof |
| CN201510604650.1A CN105106672A (en) | 2014-01-13 | 2014-01-13 | Preparation method for poultice for vulva care |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412617A (en) * | 2017-08-07 | 2017-12-01 | 于瑞霞 | A kind of Chinese medicine composition for treating pregnant eczema of vulva and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101637585A (en) * | 2009-08-20 | 2010-02-03 | 卢速江 | Chinese herbal preparation for treating posirasis and preparation method thereof |
| CN101664488A (en) * | 2009-09-16 | 2010-03-10 | 刘陶钧 | Traditional Chinese medicine for treating infant eczema |
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| CN1325071C (en) * | 2005-12-22 | 2007-07-11 | 潘正国 | Antiphlogistic medicine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101637585A (en) * | 2009-08-20 | 2010-02-03 | 卢速江 | Chinese herbal preparation for treating posirasis and preparation method thereof |
| CN101664488A (en) * | 2009-09-16 | 2010-03-10 | 刘陶钧 | Traditional Chinese medicine for treating infant eczema |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412617A (en) * | 2017-08-07 | 2017-12-01 | 于瑞霞 | A kind of Chinese medicine composition for treating pregnant eczema of vulva and preparation method thereof |
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