CN105194296A - Medicine composition for treating heart diseases - Google Patents
Medicine composition for treating heart diseases Download PDFInfo
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- CN105194296A CN105194296A CN201510749066.5A CN201510749066A CN105194296A CN 105194296 A CN105194296 A CN 105194296A CN 201510749066 A CN201510749066 A CN 201510749066A CN 105194296 A CN105194296 A CN 105194296A
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Abstract
The invention provides a medicine composition for treating heart diseases. The medicine composition is characterized in that a prescription of the medicine composition comprises 10-40 parts of radix astragali, 10-20 parts of radix codonopsis, 15-45 parts of plantain seed, 10-25 parts of red paeony root, 10-15 parts of dwarf lilyturf tuber, 1-25 parts of grass leaf sweetflag rhizome, 1-10 parts of thinleaf milkwort root-bark and 1-20 parts of liquorice root by weight. The medicine preparation has the functions of benefiting qi and promoting urination and nourishing yin and activating pulse, is simple in components and scientific and reasonable in formula and has obvious curative effects on heart diseases.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of pharmaceutical composition for the treatment of heart disease.
Background technology
Heart disease is the general name of heart disease, comprises the various heart diseases such as rheumatic heart disease, congenital heart disease, hypertensive heart disease, coronary heart disease, myocarditis.The number one killer of the mankind is sudden cardiac arrest (being called for short SCA).At present according to the numeral that World Health Organization (WHO) issues, the whole world, often in dead 3 people, just has 1 people to die from cardiovascular disease, China, has hundreds of thousands people to die from heart disease every year.Heart disease has very large puzzlement and threat to patient, although have in some now, western medicine mode, curative effect is all comparatively general, can not effectively alleviate heart disease preferably and treat.Therefore, develop a kind ofly to have no side effect, scientific formulation, taking convenience, treatment heart disease evident in efficacy medicine be desirable.
Summary of the invention
The present invention aims to provide a kind of scientific formula, stable curative effect, the cardiopathic Chinese medicine composition for the treatment of that has no side effect.
For achieving the above object, a kind of pharmaceutical composition for the treatment of heart disease of the present invention, its specific embodiments is:
A kind of pharmaceutical composition for the treatment of heart disease of the present invention, is characterized in that this pharmaceutical composition prescription number is counted: Radix Astragali 10-40 part, Radix Codonopsis 10-20 part, Semen Plantaginis 15-45 part, Radix Paeoniae Rubra 10-25 part, Radix Ophiopogonis 10-15 part, Rhizoma Acori Graminei 1-25 part, Radix Polygalae 1-10 part, Radix Glycyrrhizae 1-20 part.
Further, a kind of pharmaceutical composition for the treatment of heart disease of the present invention, it is characterized in that this pharmaceutical composition prescription number is counted: Radix Astragali 15-35 part, Radix Codonopsis 12-18 part, Semen Plantaginis 18-32 part, Radix Paeoniae Rubra 12-18 part, Radix Ophiopogonis 12-15 part, Rhizoma Acori Graminei 5-15 part, Radix Polygalae 5-10 part, Radix Glycyrrhizae 5-15 part.
Further, a kind of pharmaceutical composition for the treatment of heart disease of the present invention, is characterized in that this pharmaceutical composition prescription number is counted: the Radix Astragali 20 parts, Radix Codonopsis 15 parts, Semen Plantaginis 20 parts, Radix Paeoniae Rubra 15 parts, Radix Ophiopogonis 12 parts, Rhizoma Acori Graminei 10 parts, Radix Polygalae 5,10 parts, Radix Glycyrrhizae.
Pharmaceutical composition described in any one of the present invention, is characterized in that, described preparation is oral formulations.
Further, preparation of the present invention, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, capsule, granule, electuary and oral liquid.
Further, preparation of the present invention, is characterized in that, described preparation is capsule.
Further, preparation of the present invention, is characterized in that, the preparation method of this capsule is: 1) by the recipe quantity Radix Astragali, Radix Codonopsis, Semen Plantaginis, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Polygalae, Radix Glycyrrhizae wears into coarse powder, and mixing, according to the percolation under fluid extract and extractum item, with 6-8 times amount 60% ethanol as solvent, dipping 15-20 hour, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 4-8 times amount soak by water 0.5-2 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granulates, filled capsules and get final product.
The each component pharmacology analysis of prescription of the present invention:
The Radix Astragali: sweet, tepor.Return lung, spleen, liver, kidney channel.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Semen Plantaginis: sweet, cold.Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.
Radix Paeoniae Rubra: bitter, is slightly cold.Return Liver Channel.There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling.
Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.Return lung, the heart, stomach warp.Radix Ophiopogonis effect: nourishing YIN and moistening the lung, reinforcing stomach reg fluid, clear away heart-fire relieving restlessness.
Rhizoma Acori Graminei: pungent, temperature.GUIXIN, stomach warp.Rhizoma Acori Graminei effect: eliminate the phlegm and have one's ideas straightened out, removing dampness is whetted the appetite, the mind calming and mentality promoting.
Radix Polygalae: bitter, pungent, tepor.Enter the heart, lung, kidney channel.Radix Polygalae effect: Fructus Alpiniae Oxyphyllae of calming the nerves, eliminates the phlegm and has one's ideas straightened out, subduing inflammation.
Radix Glycyrrhizae: another name: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet root, feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.
Wherein Radix Astragali QI invigorating is our monarch drug, Semen Plantaginis, Radix Paeoniae Rubra, Radix Ophiopogonis Rhizoma Acori Graminei regulating qi-flowing for strengthening spleen, phlegm reduction of blood circulation promoting is our ministerial drug, Radix Polygalae, mind tranquilizing and the heart calming, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.The main clinical severe palpitation of we, sensation of oppression over the chest with shortness of breath patient take effect significantly.
Beneficial effect of the present invention is:
1. prescription scientific formulation, evident in efficacy.
2. prescription crude drug source is wide, and technique is simple, is applicable to large-scale production, has industrialization prospect.
Detailed description of the invention
The present invention is further illustrated below for embodiment.
Embodiment 1
Prescription:
The Radix Astragali 20 parts, Radix Codonopsis 15 parts, Semen Plantaginis 20 parts, Radix Paeoniae Rubra 15 parts, Radix Ophiopogonis 12 parts, Rhizoma Acori Graminei 10 parts, Radix Polygalae 5,10 parts, Radix Glycyrrhizae.
Preparation technology:
1) by the recipe quantity Radix Astragali, Radix Codonopsis, Semen Plantaginis, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Polygalae, Radix Glycyrrhizae wears into coarse powder, mixing, according to the percolation under fluid extract and extractum item, with 7 times amount 60% ethanol as solvent, flood 18 hours, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 7 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granulates, filled capsules and get final product.
Embodiment 2
Prescription:
The Radix Astragali 20 parts, Radix Codonopsis 15 parts, Semen Plantaginis 20 parts, Radix Paeoniae Rubra 15 parts, Radix Ophiopogonis 12 parts, Rhizoma Acori Graminei 10 parts, Radix Polygalae 5,10 parts, Radix Glycyrrhizae.
Preparation technology:
1) by the recipe quantity Radix Astragali, Radix Codonopsis, Semen Plantaginis, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Polygalae, Radix Glycyrrhizae wears into coarse powder, mixing, according to the percolation under fluid extract and extractum item, with 8 times amount 60% ethanol as solvent, flood 16 hours, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 6 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granulates, filled capsules and get final product.
Embodiment 3
Prescription:
The Radix Astragali 20 parts, Radix Codonopsis 15 parts, Semen Plantaginis 20 parts, Radix Paeoniae Rubra 15 parts, Radix Ophiopogonis 12 parts, Rhizoma Acori Graminei 10 parts, Radix Polygalae 5,10 parts, Radix Glycyrrhizae.
Decoction preparation technology:
First, by the recipe quantity Radix Astragali, Radix Codonopsis, Semen Plantaginis, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Polygalae, licorice medicinal materials warm water is soaked 20 minutes (water yield of immersion is advisable to flood powder 2 ~ 3cm); Secondly, be placed on by medicine on fire, endure out with big fire, timing after boiling, decocts 60 minutes; Finally, first time fried medicinal liquid is poured out, add appropriate hot water (being advisable just to flood medical material) and carry out second time and decoct, about the about 30 minutes time of second time decoction.To mix with second time medicinal liquid by medicinal liquid for the first time, obtain decoction of the present invention.
Embodiment 4
Prescription:
The Radix Astragali 20 parts, Radix Codonopsis 15 parts, Semen Plantaginis 20 parts, Radix Paeoniae Rubra 15 parts, Radix Ophiopogonis 12 parts, Rhizoma Acori Graminei 10 parts, Radix Polygalae 5,10 parts, Radix Glycyrrhizae.
Preparation Technology of Granules:
1) by the recipe quantity Radix Astragali, Radix Codonopsis, Semen Plantaginis, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Polygalae, Radix Glycyrrhizae wears into coarse powder, mixing, according to the percolation under fluid extract and extractum item, with 7 times amount 60% ethanol as solvent, flood 18 hours, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 7 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granule processed, to obtain final product.
Embodiment 5
Prescription:
The Radix Astragali 20 parts, Radix Codonopsis 15 parts, Semen Plantaginis 20 parts, Radix Paeoniae Rubra 15 parts, Radix Ophiopogonis 12 parts, Rhizoma Acori Graminei 10 parts, Radix Polygalae 5,10 parts, Radix Glycyrrhizae.
Tablet producing technology:
1) by the recipe quantity Radix Astragali, Radix Codonopsis, Semen Plantaginis, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Polygalae, Radix Glycyrrhizae wears into coarse powder, mixing, according to the percolation under fluid extract and extractum item, with 7 times amount 60% ethanol as solvent, flood 18 hours, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 7 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, tabletting and get final product.
Clinical application effect of the present invention:
One, physical data accepts patient's totally 200 examples for medical treatment, 45 years old mean age.
Two, Therapeutic Method is according to Medications Example one of the present invention, and capsule prepared by preferred preparation method, one day three times, each three, decoction being taken warmly.It within 30th, is a course for the treatment of.Three, therapeutic outcome statistics
Treat after 30 days, fully recover 121 people, effective 53 people, invalid 26 people, total effective rate 87%.Wherein: total effective rate=cure rate+effective percentage.It should be noted that; above-described embodiment is only preferred embodiment of the present invention; be not used for limiting protection scope of the present invention; protection scope of the present invention is as the criterion with claims; equivalent replacement done on the basis of technique scheme or substitute, all belongs to protection scope of the present invention.
Claims (7)
1. treat a pharmaceutical composition for heart disease, it is characterized in that this pharmaceutical composition prescription number is counted: Radix Astragali 10-40 part, Radix Codonopsis 10-20 part, Semen Plantaginis 15-45 part, Radix Paeoniae Rubra 10-25 part, Radix Ophiopogonis 10-15 part, Rhizoma Acori Graminei 1-25 part, Radix Polygalae 1-10 part, Radix Glycyrrhizae 1-20 part.
2. a kind of pharmaceutical composition for the treatment of heart disease according to claim 1, it is characterized in that this pharmaceutical composition prescription number is counted: Radix Astragali 15-35 part, Radix Codonopsis 12-18 part, Semen Plantaginis 18-32 part, Radix Paeoniae Rubra 12-18 part, Radix Ophiopogonis 12-15 part, Rhizoma Acori Graminei 5-15 part, Radix Polygalae 5-10 part, Radix Glycyrrhizae 5-15 part.
3. a kind of pharmaceutical composition for the treatment of heart disease according to claim 1, is characterized in that this pharmaceutical composition prescription number is counted: the Radix Astragali 20 parts, Radix Codonopsis 15 parts, Semen Plantaginis 20 parts, Radix Paeoniae Rubra 15 parts, Radix Ophiopogonis 12 parts, Rhizoma Acori Graminei 10 parts, Radix Polygalae 5,10 parts, Radix Glycyrrhizae.
4. the pharmaceutical composition according to any one of claim 1-3, is characterized in that, described preparation is oral formulations.
5. preparation according to claim 4, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, capsule, granule, electuary and oral liquid.
6. preparation according to claim 5, is characterized in that, described preparation is capsule.
7. preparation according to claim 6, is characterized in that, the preparation method of this capsule is: 1) by the recipe quantity Radix Astragali, Radix Codonopsis, Semen Plantaginis, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Polygalae, Radix Glycyrrhizae wears into coarse powder, and mixing, according to the percolation under fluid extract and extractum item, with 6-8 times amount 60% ethanol as solvent, dipping 15-20 hour, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 4-8 times amount soak by water 0.5-2 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granulates, filled capsules and get final product.
Priority Applications (1)
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| CN201510749066.5A CN105194296A (en) | 2015-11-08 | 2015-11-08 | Medicine composition for treating heart diseases |
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| CN201510749066.5A CN105194296A (en) | 2015-11-08 | 2015-11-08 | Medicine composition for treating heart diseases |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115177691A (en) * | 2022-07-18 | 2022-10-14 | 河南中医药大学第一附属医院 | Traditional Chinese medicine composition for treating ventricular premature beat and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007182415A (en) * | 2006-01-06 | 2007-07-19 | Kunio Suetsuna | New wakame seaweed peptide, l-tyrosyl-l-proline and antihypertensive agent |
| CN102657828A (en) * | 2012-03-21 | 2012-09-12 | 李秀环 | Pharmaceutical composition for treating chronic heart failure |
-
2015
- 2015-11-08 CN CN201510749066.5A patent/CN105194296A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007182415A (en) * | 2006-01-06 | 2007-07-19 | Kunio Suetsuna | New wakame seaweed peptide, l-tyrosyl-l-proline and antihypertensive agent |
| CN102657828A (en) * | 2012-03-21 | 2012-09-12 | 李秀环 | Pharmaceutical composition for treating chronic heart failure |
Non-Patent Citations (1)
| Title |
|---|
| 杨思澍: "《中国现代名医验方荟海》", 29 February 1996, 湖北科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115177691A (en) * | 2022-07-18 | 2022-10-14 | 河南中医药大学第一附属医院 | Traditional Chinese medicine composition for treating ventricular premature beat and application thereof |
| CN115177691B (en) * | 2022-07-18 | 2023-06-06 | 河南中医药大学第一附属医院 | Traditional Chinese medicine composition for treating ventricular premature beat and application thereof |
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Application publication date: 20151230 |