CN105232958A - Traditional Chinese medicine combination for preparing medicine for treating myasthenia gravis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine combination for preparing medicine for treating myasthenia gravis. The combination has an immune reconstitution function, can be used for preparing medicine for treating diseases of immune systems and is especially suitable for treating myasthenia gravis.

Description

A kind of Chinese medicine composition of the medicine for the preparation for the treatment of myasthenia gravis

Technical field

The present invention relates to Chinese medicine composition, is the Chinese medicine composition of immunity moderation systemic-function, specifically for the preparation of the Chinese medicine composition for the treatment of myasthenia gravis medicine, relates to tcm field.

Background technology

Immune system is the defensive structure of body protective self, primarily of compositions such as lymphatic organ (thymus, lymph node, spleen, tonsil), other intraorganic lymphoid tissue and whole body lymphocyte everywhere, antigen-presenting cells.Immune system has the discriminative power of height, accurately can identify oneself and non-own material, to maintain the relative stability of body; Can also accept simultaneously, transmit, expand, store and remember the information about immunity, for response also continuous its responsiveness of adjustment of immunologic information generation positive and negative.Immune system mainly plays a part physiological defense, homeostasis and immune surveillance in human body, is that human body is resisted pathogen and invaded most important safeguard system.Immunologic function just easily produces disease once disequilibrium.Weakened immune system, easily cause the infection of antibacterial, virus, fungus, immune system is hyperfunction, can bring out autoimmune disease.

Fast pace, high efficiency modern society, dog-eat-dog, mental pressure are large, in the tense situation of overload operation, this situation as do not dissolved in time, is then easy to the disease producing physiology and psychology usually to make people be in for a long time.When various factors bring out immune system normally can not play protective effect time, immunologic function will be caused unbalance.

Myasthenia gravis is that the one that neuro-muscular place acetylcholine conductive impairment causes is chronic, autoimmune disease, and main manifestations is that some striped muscle is abnormal easily tired, usually aggravates after activity, alleviates after rest.The cause of disease of myasthenia gravis still has multiple saying at present: one, is that on nerve synapse caudacoria, acetylcholinergic receptor (AchR) number obviously reduces (about reducing 70-80%), and has anti-receptor protein to exist, receptor is degenerated, decreased number.Its two, be, by with AchR, there is the viral infection of same or similar surface antigen, cause body immune system and excessively reply, involve AchR, cause ArchR to be destroyed.Its three, such as the environmental pollution of some environmental factors causes immunity disorderly; The extrinsic factor such as transition is tired, excited, long-term nutrition is bad can cause the generation of myasthenia gravis equally.

Modern medicine comprises for the Therapeutic Method of myasthenia gravis:

1, thymectomy, Patients With Myasthenia Gravis more than 90% has thymus abnormalities, thymusectomy is one of effective treatment means of myasthenia gravis, be applicable to the whole body type of intercurrent disease, the Patients With Myasthenia Gravis without surgical contraindication at 16 ~ 60 years old, Most patients obtains remarkable improvement thymusectomy is postoperative.

2, cholinesterase inhibitor, such medicine is the medicine of symptomatic treatment, cures the symptoms, not the disease, can not single medicine prolonged application, and administrated method should be cumulative from low dose.Conventional has neostigmine methylsulfate, pyridostigmine bromide.

3, immunosuppressant, conventional immunosuppressant is: 1. Corticosteroid: prednisone, methyl meticortelone etc.; 2. azathioprine; 3. cyclosporin A; 4. cycli phosphate amine; 5. tacrolimus.

4, plasmapheresis, by the mode removed by acetylcholine receptor antibodies in blood samples of patients, is usually used in the critical symptom that respite Patients With Myasthenia Gravis occurs, as not auxiliary other treatment mode, curative effect is no more than 2 months.

6, immunoglobulin'intravenous, containing Multiple Antibodies in human immunoglobulin, can in and autoantibody, immunity moderation function.Its effect is suitable with plasmapheresis.

Current, the Chinese traditional treatment of myasthenia gravis more and more comes into one's own.Myasthenia gravis belongs to " flaccidity " category.According to theory of Chinese medical science, treatment adds with Chinese medicine, the side effect that immunosuppressant is brought can be reduced, the treatment of myasthenia gravis plays a part to escort, and effect of autoimmune function can be rebuild.

The traditional Chinese medical science think disease generation, develop and lapse to the growth and decline depending on good and evil, closely related with the immunologic function of body, thus propose the principle of mainly curing the disease of strengthening vital QI to eliminate pathogenic factors.Point out the immunology thought of " healthy energy deposit in, heresy can not be done " in "Nei Jing" before bimillennium, " Plain Questions " is commented in calentura and is pointed out " gathering of heresy, its gas must be empty ".Human righteousness is prosperous and powerful, can control pathogen, make it not fall ill, even if morbidity also drives pathogen in body surface, and the state of an illness is lighter; On the contrary, its deficiency of vital QI, pathogen is then driven straight in, and invades internal organs, makes disease position dark and state of an illness weight.Healthy energy is prosperous and powerful, effectively disease-resistant, then good behind top; Deficiency of vital QI, without resisting heresy strenuously, then prognosis mala.Righting refers to helps body healthy energy, health invigorating, improves a kind of Therapeutic Principle of the anti-heresy of body, resistance against diseases, by strengthening the method for healthy energy, getting rid of evils and going out, situation of getting well.Therefore the healthy energy enhancing immunity of mediating a settlement in Immunology Today in the visible traditional Chinese medical science is consistent.

TCM is thought, the innate deficiency of myasthenia gravis, lacks of proper care after one's birth, or emotional stimulation, or exopathogen hindered, or wrong treatment is controlled in disease mistake, or loses foster after being ill, all can cause deficiency of spleen-QI and stomach-QI, gradually amasss empty one-tenth and damages.Therefore, the pathogenesis of myasthenia gravis is mainly taste disease damage.The spleen and stomach provide the material basis of the acquired, the source of QI and bloodization life, occupy middle Jiao, for ascending or descending movement of vital Qi goes out the important department of people.The main fortune of the main liter of spleen, sinking of QI due to deficiency of the spleen, then elevate a turnable ladder is unable, and upper eyelid belongs to spleen, therefore it is unable and sagging to carry eyelid; Spleen governing muscles extremity, insufficiency of the spleen biochemistry moisten support not enough, therefore extremity wither soft can not with; Main receiving falls in stomach master, and with spleen phase the exterior and the interior, insufficiency of the spleen stomach is also weak, then the dysfunction of acting as a pivot of lifting, is received and have no right, thus indigestion and loss of appetite diarrhea with loose stool, dysphagia; Splenic qi tending to ascend, above fills in lung, amasss in being pectoral qi (air) in the heart, and department breathes, and pass through hundred arteries and veins, sinking of QI of middle-JIAO, air is in the heart difficult to continue, and the include of lung is unable, therefore inability to breathe regularly due to shortness of breath, if air also sink in the heart, then breath will stop, and endanger in a moment.

But, though partial immunity systemic disease be treated or be cured to the medicine of modern medicine can, for stubborn disease to a certain extent, effect is poor, and this type of immunomodulator of long-term taking, more easily make originally fragile balance thoroughly be broken, so that take medicine throughout one's life.Current Chinese medicine myasthenia gravis is more using Chinese medicine as auxiliary treatment means, treats in order to reduce western modern medicine the side effect brought, and reduces patient suffering, improves the quality of living.At present, there is no the report of alone Chinese medicine myasthenia gravis.

Summary of the invention

For overcoming deficiency of the prior art, for treatment myasthenia gravis provides better medicine, applicant now discloses a kind of Chinese medicine composition.

Through for many years in the research of the amyasthenic pathogenesis of serious symptom, the cause of disease and symptom etc. and the process for the treatment of, applicant thinks that the pathogenesis of myasthenia gravis is: positive QI-insufficiency and exopathogen invasion, and positive QI-insufficiency, visceral-qi virtual loss to be it basic because of.Therefore empty many whole story through disease, but originally disease mostly is real, after exopathogen wound is dirty, and then develops into void.Applicant is through constantly summing up and repeatedly groping, propose brand-new myasthenia gravis Chinese traditional treatment theoretical, namely to consolidate righting for elder generation, improve body self to the ability of anti-disease, again pathogen is drawn from each internal organs, and guide descending, accelerate the flowing of healthy energy in body afterwards, supplement and make each dirty " deficiency of vital energy " because of leaving away of pathogen.

Chinese medicine composition of the present invention is as described below:

A kind of Chinese medicine composition, it is characterized in that, raw material comprises Rhizoma Polygonati 1-45 part, Rhizoma Acori Calami 1-25 part, Fructus Chebulae 1-37 part, Rhizoma Acori Graminei 1-45 part, Fructus Terminaliae Billericae 1-45 part, east Fructus Fragariae Ananssae 1-23 part, Stigma Croci 1-10 part, and is selected from least one in CATECHU 1-15 part, Sedumviviparum 1-29 part, Herba Gnaphalii Affinis 1-34 part.

Further, raw material comprises Rhizoma Polygonati 1-45 part, Rhizoma Acori Calami 1-25 part, Fructus Chebulae 1-37 part, Rhizoma Acori Graminei 1-45 part, Fructus Terminaliae Billericae 1-45 part, east Fructus Fragariae Ananssae 1-23 part, Stigma Croci 1-10 part, and is selected from least two kinds in CATECHU 1-15 part, Sedumviviparum 1-29 part, Herba Gnaphalii Affinis 1-34 part.

Further, raw material comprises Rhizoma Polygonati 1-45 part, Rhizoma Acori Calami 1-25 part, Fructus Chebulae 1-37 part, Rhizoma Acori Graminei 1-45 part, Fructus Terminaliae Billericae 1-45 part, east Fructus Fragariae Ananssae 1-23 part, Stigma Croci 1-10 part, CATECHU 1-15 part, Sedumviviparum 1-29 part, Herba Gnaphalii Affinis 1-34 part.

Further, each raw material weight consumption is Rhizoma Polygonati 3-38 part, Rhizoma Acori Calami 1-20 part, Fructus Chebulae 1-28 part, Rhizoma Acori Graminei 1-37 part, Fructus Terminaliae Billericae 1-40 part, east Fructus Fragariae Ananssae 1-18 part, Stigma Croci 1-8 part, CATECHU 1-10 part, Sedumviviparum 1-25 part, Herba Gnaphalii Affinis 1-30 part.

Further, each raw material weight consumption is Rhizoma Polygonati 8-30 part, Rhizoma Acori Calami 5-17 part, Fructus Chebulae 5-20 part, Rhizoma Acori Graminei 6-28 part, Fructus Terminaliae Billericae 15-31 part, east Fructus Fragariae Ananssae 3-15 part, Stigma Croci 2-6 part, CATECHU 2-8 part, Sedumviviparum 1-10 part, Herba Gnaphalii Affinis 1-25 part.

In this Chinese medicine composition, based on Rhizoma Polygonati, Rhizoma Acori Calami, Fructus Chebulae, Rhizoma Acori Graminei, Fructus Terminaliae Billericae, Stigma Croci, Herba Gnaphalii Affinis, the merit of Rhizoma Polygonati tool boosting qi and nourishing yin, spleen invigorating lung moistening kidney tonifying, consolidates body substrate, improves healthy energy, refreshes oneself; Rhizoma Acori Calami stomach warming, anti-inflammatory analgetic, in adjustment side, the medicine of cool property is unlikely to exceed the proper limits in righting a wrong and stomach is caught cold; Fructus Chebulae's astringing lung-QI and relieving cough, relieving diarrhea with astringents, pathogenic fire reducing sore-throat relieving, help Rhizoma Polygonati plays the merit that tonification consolidates; Rhizoma Acori Graminei removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, and in body aid, pathogen is discharged; Fructus Terminaliae Billericae heat-clearing and toxic substances removing, convergence nourish blood, and concoct all medicines; Stigma Croci blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization; East Fructus Fragariae Ananssae tool stops blooding, eliminate the phlegm, effect of dry pus; This few taste medicine synergism, jointly reach toxin expelling righting, nourish effect of internal organs,

According to the difference of individual patients body constitution and disease concrete manifestation, can select to increase the medical materials such as CATECHU, Herba Gnaphalii Affinis and Sedumviviparum.Effect of CATECHU tool promoting blood circulation and hemostasis, hemostasia and promoting granulation, removing dampness sore, removing heat from the lung and dissipating phlegm, coordinates with above-mentioned all medicines, can strengthen prescription effect to lung, increase the function of promoting blood circulation and hemostasis, promoting tissue regeneration and ulcer healing simultaneously, be applicable to patient occur together hematoma, skin infection, fester.Herba Gnaphalii Affinis relieving cough and expelling phlegm, has mitigation to lung symptoms.Sedumviviparum tool benefiting QI for activating blood circulation, effect of relievining asthma of promoting blood circulation, coordinate with above-mentioned all medicines, can strengthen effect of the lung qi dispersing of regulating the flow of vital energy of prescription, be applicable to the diseases such as asthma uncomfortable in chest.Three taste medicines herein all can according to circumstances add alone or combine and add.

For strengthening effect of one of them aspect of this Chinese medicine composition, compositions provided by the present invention can also comprise at least one and be selected from the Radix Astragali, Herba Ipomoeae Cairicae, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Herb Gynostemmae Pentaphylli.Above-mentioned all medicines are has one of effect such as QI invigorating, spleen invigorating, stomach invigorating, this type of medicine is inserted prescription, can specialization prescription to lung, the taking good care of of spleen, be applicable to the patient that the deficiency of vital energy, taste are impaired.

Same, for strengthening this prescription to the nourishing of spleen, stomach and conditioning, also can increase in prescription and comprising Rhizoma Pinelliae Preparatum, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae, Fructus Mume, Galla Chinensis, Halloysitum Rubrum, Semen Myristicae.The equal tool spleen invigorating of said medicine, whet the appetite, regulate the flow of vital energy or one of anti-diarrhea effect.In clinical practice, have the empty gas of some patients body weak, cause taste impaired, long-pending dyspepsia, inappetence, have impact on the picked-up of dietary changes, exacerbates the state of an illness.Add these medicines and can strengthen this Chinese medicine composition to the nourishing of spleen, stomach and conditioning, treatment taste pathological changes, can nurse one's health digestive tract function, appetite strengthening, improve nutrition intake, increase the ability of body self resist the disease.

Further, the tonification effect for strengthening this prescription, also can increase at least one in prescription is selected from Fructus Corni, Cordyceps, Radix Morindae Officinalis, Cornu Cervi Pantotrichum, the Cortex Eucommiae, Semen Cuscutae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Polygoni Multiflori Preparata, Radix Asparagi, Radix Adenophorae.Said medicine tool YANG invigorating, one of nourishing YIN and nourishing blood function.In clinical practice, because of the myasthenia gravis that malnutrition causes, adding these medicines for the treatment of this type of disease, but can need the pattern of syndrome distinguishing patient in practice, dialectically treats.

On the other hand, use Chinese medicine composition provided by the invention, add suitable pharmaceutically acceptable adjuvant alternatively, the Chinese medicine preparation can treating myasthenia gravis can be prepared, its method can be the Chinese medicine preparation production method of any conventional, produces the dosage form of any routine.Consider compliance and the drug effect of patient, described preparation is preferably peroral dosage form, is more preferably buccal tablet, powder, capsule or oral liquid, is more preferably buccal tablet, powder, oral liquid, most preferably is powder.

The method of preparation can be:

1) each raw material is after choosing and mixing, and takes, and grouping is put well for subsequent use;

2) each group raw material cutting, pulverizes respectively, crosses No. 2 standard screens;

3) powder is mixed, obtain described active constituents of medicine compositions;

4) by 3) active ingredient compositions that obtains, by standard preparation operation, the difference according to made dosage form adds pharmaceutic adjuvant, carries out being processed into preparation.

Such as, the method Chinese medicine composition provided being prepared into powder is: use the Chinese medicine composition provided, by each crude drug cutting, pulverize, mix and obtain powder.During use, described powder is got it filled by consumption standard, is placed in sublingual administration, swallow after about 5-10 minute, within 30 minutes after swallowing, can drink water.

Again such as, the Chinese medicine composition provided is prepared into the method for oral liquid: by the compositions that provides through soak by water, condensed water decocting liquid afterwards, add pharmaceutically acceptable correctives, odor mask, diluent again, as sucrose, refined honey etc. are arranged in pairs or groups with it, make oral liquid, after sterilizing, fill becomes bottle.How to decoct, follow general guide principle and the customary means of this area, such as, need in prescription add Semen Myristicae, then decoct time, Semen Myristicae should afterwards under.

Again such as, the Chinese medicine composition provided is prepared into the method for buccal tablet: by the Chinese medicine composition powder that provides and the additive of tablet be applicable to, as mannitol, magnesium stearate, dextrin etc., mixing, wet granulation, dry, granulate, tabletting and get final product.

In order to make each crude drug in compositions better play drug effect, preferably carry out water extraction or alcohol extraction to each crude drug, the solvent of how selective extraction, follows the usual way of this area.If selected Radix Salviae Miltiorrhizae, then water extraction is carried out to Radix Salviae Miltiorrhizae, got its Aqueous extracts concentrated spray dry that radix Salviae Miltiorrhizae water extract carries out preparation; If selection Semen Myristicae, then alcohol extraction is carried out to Semen Myristicae, get its alcohol extract and carry out preparation through concentrated.But these can not be used for limiting the scope of the invention.

When there is no Chinese medicine extraction condition, preferably the compositions provided is made buccal tablet or powder.

Chinese medicine preparation disclosed by the invention has heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, lung moistening are eliminated the phlegm, spleen benefiting and stimulating the appetite, tonification are calmed the nerves, effect of antidiarrheal sore, there is the ability regulating immunity of organisms, unbalance immune system is recovered normal, be applicable to the disease because immune imbalance causes, be especially suitable for treating myasthenia gravis.

Preferably, the each amounts of components of compositions used in the present invention is: Rhizoma Polygonati 5-20 part, Rhizoma Acori Calami 1-30 part, Fructus Chebulae 1-25 part, Rhizoma Acori Graminei 1-25 part, Fructus Terminaliae Billericae 1-25 part, Stigma Croci 1-10 part, Herba Gnaphalii Affinis 1-35 part, CATECHU 1-15 part, east Fructus Fragariae Ananssae 1-25 part, Sedumviviparum 1-12 part.

Preferred, the each amounts of components of compositions used in the present invention is: Rhizoma Polygonati 8-18 part, Rhizoma Acori Calami 3-27 part, Fructus Chebulae 3-22 part, Rhizoma Acori Graminei 4-21 part, Fructus Terminaliae Billericae 5-17 part, Stigma Croci 1-7 part, Herba Gnaphalii Affinis 1-30 part, CATECHU 2-12 part, east Fructus Fragariae Ananssae 1-22 part, Sedumviviparum 1-10 part.

the Chinese crude drug related in the present invention program is described as follows:

Rhizoma Polygonati, for Liliaceae HUANGJING ZANYU CAPSULE Rhizoma Polygonati Polygonatumsibiricum, P. kingianum PolygonatumkingianuColl.EtHemsl. or Polygonatum cyrtonema Hua PolygonatumcyrtonemaHua Rhizoma Polygonati cathcartii PolygonatumcathcartiiBaker. polygonatum cirrhifolium Royle P.cirrthifolium (Wall.) Royle and to cry Rhizoma Polygonati P.oppositifolium (Wall.) Royle in dry rhizome.Different according to shape, practise and claim " large Rhizoma Polygonati " " polygonatum sibiricum Redoute " " RHIZOMA POLYGONATI ZINGIBERIFORME ".Rhizoma Polygonati has boosting qi and nourishing yin, spleen invigorating, lung moistening, effect of kidney tonifying.When selecting Rhizoma Polygonati, tonification effect of we can be increased, be suitable for empty, weak, the lethargy person of body.Modern technologies can isolate steroid saponin from Rhizoma Polygonati rhizome, comprise 2 furan steroid enol form Saponins and 2 spirostene alcohol type Saponins.Belong to the former: 26-O-β-D-glucopyranosyl-22-O-methyl-(25) S-furan steroid-5-alkene-3 β, 26-glycol 3-O-β-lycotetraose glycoside (26-O-β-D-glucopyranosyl-22-O-methyl-25(S)-furost-5-ene-3 β, 26-diol3-O-β-lycotetraoside) namely herba Polygoni sibirici glycoside A(sibiricoside-A) with 26-O-β-D-glucopyranosyl-22-O-methyl-25(S)-furan steroid-5-alkene-3 β, 14 α, 26-triol 3-O-β-lycotetraose glycoside (26-O-β-D-glucopyranosyl-22-O-methyl-25(S)-fruost-5-ene-3 β, 14 α, 26-triol3-O-β-lycotetraoside) namely 14 Alpha-hydroxy Herba Polygoni sibirici glycoside A (14 α-hydroxysibiricosideA); Belong to the latter: ((23S, 25R) spiral shell steroid-5-alkene-3 β, 14 α, 23-triol 3-O-β-lycotetraoside) namely herba Polygoni sibirici glycoside B (sibiricosideB) and new bus draws time diosgenin-A3-O-β-lycotetraose glycoside (neoprazerigeninA3-O-β-lycotetraoside).Another containing polygonatum polysaccharide A, B, C, the relative molecular mass of three is all greater than 200,000, forms according to mol ratio 6:26:1 condensation by glucose (glucose), mannose (mannose) and galacturonic acid (galacturonicacid); Again containing polygonatum rhizome oligosaccharide A, B, C, relative molecular mass is respectively 1630,862 and 472, is to be formed by fructose (fructose) and glucose 8:1.4:1 and 2:1 condensation in molar ratio.Effect that Rhizoma Polygonati has is relevant with above-mentioned effective ingredient.

Herba Gnaphalii Affinis, is Compositae cottonweed Herba Gnaphalii Affinis (Gnaphaliumaffine), has another name called Gnaphalium affine D. Don..Be used as medicine with dry herb or inflorescence, effect of tool relieving cough and expelling phlegm.In Tibetan medicine classics " Jingzhubencao ", its name of Herba Gnaphalii Affinis is recited as " fragrant blue or green ", is divided into HUANGBAI(sic) two kinds." Chinese Tibetan medicine " the 3rd volume (institute for drug control, Qinghai Province, Qinghai Tibet Medical Institute chief editor, Shanghai science tech publishing house, 1996) record, " Gan Dabazha " Bai Zhewei Herba Anaphalidis Lacteae (AnaphalislactcaMaxim), Huang person is Herba Gnaphalii Affinis, the two all " control Baconic's disease, go painful abdominal mass tumor ".And fragrant green grass or young crops is Compositae anaphalis plant, anaphalis was once incorporated in Gnaphalium affine D. Don. and belonged to, and the two is mainly sterile for difference with hermaphrodite flower.It can thus be appreciated that, though Herba Gnaphalii Affinis and perfume (or spice) green grass or young crops belong to different plant species in Plant Taxonomy, there is extremely close sibship, and there is identical effect. therefore, Herba Gnaphalii Affinis and perfume (or spice) green grass or young crops can exchange use.

CATECHU, for pulse family sallee catechu ( acaciacatechu (L.f.) Willci.) peeling branch, dry dry soft extracts, there is promoting blood circulation and stopping pain, hemostasia and promoting granulation, removing dampness sore, effect of removing heat from the lung and dissipating phlegm.

Sedumviviparum, be Crassulaceae sengreen Sedumviviparum (Sedumbulbiferum, another name Herba Hydrocharitis dubiae), herb can be used as medicine, and is excellent with its dry root welding technology.There is benefiting QI for activating blood circulation, effect of relievining asthma of promoting blood circulation.

Fructus Chebulae is the mature fruit of Combretum Racemosum Fructus Chebulae platymiscium Fructus Chebulae (TerminaliachebulaRetz.), also known as chebule, and microtriche Fructus Chebulae.Effect of Fructus Chebulae's tool astringing lung-QI and relieving cough, relieving diarrhea with astringents, pathogenic fire reducing sore-throat relieving.In Tibetan medicine system, Fructus Chebulae is the most frequently used Tibetan medicine material, is regarded as " king of Tibetan medicine ".The fruit of Fructus Chebulae, containing tannin 23.60%-37.36%, includes: chebulinic acid, Chebulagic acid, corilagin, myrobalani-tannin, 2,3-O-connects two Galla Turcica (Galla Helepensis) acyl Tannin in Punica granatum Ls, Terminalia catappa flavin, terchebin, glucogallin, 1,3,6-trigalloylglucose, gallic acid, benzoaric acid etc.Again containing triterpenes components: the acid of Terminalia catappa terpene, scold king's alcohol.Also containing shikimic acid, dehydroshikimis acid, quininic acid, 30 carbonic acid, Palmic acid, gallic acid is ester, chebulic acid three ester, daucosterol, cupreol, arabinose, fructose, glucose, sucrose, rhamnose and aminoacid etc.Another containing Sennosides, terchebin and tannase, polyphenol oxidase, peroxidase, ascorbic acid oxidase etc.Modern study shows, Fructus Chebulae also has certain anticancer function.

Rhizoma Acori Graminei, belongs to the dry root of Acorus of Araceae graminoid herbaceos perennial Rhizoma Acori Graminei (Acorustatarinowii), has another name called Rhizoma Anemones Altaicae, mountain Rhizoma Acori Graminei, medicine Rhizoma Acori Graminei, money Pu, Folium Acori graminei, water Rhizoma Acori Graminei, white flag.Rhizoma Acori Graminei rhizome is done medicinal.Be grown on the area of height above sea level 20 meters to 2600 meters, there is removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, effect of refreshment Fructus Alpiniae Oxyphyllae.

Stigma Croci, for the dry stigma of Iridaceae crocus plant Stigma Croci (CrocussativusL.), the crocetin (Crocitin) contained, safranal (safranal), crocin (Crocin) and Picrocrocin (Protocrocin), have blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization.In addition, modern technologies research shows, Stigma Croci has suppression cancer, immunity moderation power, antioxidative function.

Rhizoma Acori Calami, is the dry rhizome of aroid Rhizoma Acori Calami (AcoruscalamusL.), has stomach warming, effect of anti-inflammatory analgetic.Rhizoma Acori Calami is also known as Rhizoma Acori Calami, calamus, smelly Pu, mud Rhizoma Acori Graminei, large Rhizoma Acori Graminei.Rhizoma Acori Calami Herb is containing plurality of active ingredients, and its rhizome is containing volatile oil, and in oil, main component is α-asaricin, beta-Asarone, and other positions of herb are also containing volatile oil.Another still containing vitamin, Palmic acid, acorin fatty acid mixed and sugar.Modern pharmacology result of the test shows, Rhizoma Acori Calami has the effects such as calmness of calming the nerves, convulsion and cooling.In addition, pharmacological actions such as separating smooth muscle spasm is still had.

Fructus Terminaliae Billericae, for Combretum Racemosum Terminalia plant adjoins the dry mature fruit of Li Lekong, have heat-clearing and toxic substances removing, convergence is nourished blood, effect of coordinating the actions of various ingredients in a prescription.In its ethanol extraction, containing cupreol, gallic acid, ellagic acid, progallin A, chebulinic acid (Chehulagicacid, C41H30O27) and glucide; Another also separation from Fructus Terminaliae Billericae obtains the-Steroidal Saponins of heart tonifying.The physiologically active of Fructus Terminaliae Billericae is relevant with above-mentioned effective ingredient.

East Fructus Fragariae Ananssae is the dry herb in Rosaceae strawberry plants east Fructus Fragariae Ananssae (FragariaorientalisLosinsk).There is hemostasis, eliminate the phlegm, the effect of dry pus.East Fructus Fragariae Ananssae herb contains flavone compound, and containing a large amount of tannins etc.Saccharide 5.0 ~ 7.0%, total acid content 1.175 ~ 326%, fruit juice accounts for 70 ~ 80% of fruit.In ethnic minority traditional medicine practice, Fructus Fragariae Ananssae (F.elatiorElark.), Fragaria filipendula Hemsl. (F.filipendulaHemsi.), sow-tit (F.vescaL.) can be used as succedaneum and uses.

Rhizoma Pinelliae Preparatum is the processed product of the Araeceae Pinellia Rhizoma Pinelliae (Pinelliaternata (Thunb.) Breit.).Concocting method is: get the clean Rhizoma Pinelliae, and size separately, is soaked 10 ~ 12 days, stirred gently every day and change water 2 times, extremely without the dry heart, then use Alumen water soaking 3 days, remove Alumen water, steep 2 days again with water, add Radix Glycyrrhizae, (extracting liquorice 20kg, decocts with water 2 times to lime liquor, collecting decoction, pours in the lime liquor made by suitable quantity of water) soak, stir 1 ~ 2 every day, and keep pH value to be more than 12.0, tasting to mouth micro-ly has numb feeling in the tongue, and tangent plane is homogeneous yellow is degree, take out, clean, dry in the shade or oven drying at low temperature.The clean Rhizoma Pinelliae of every 100kg, with Radix Glycyrrhizae 20kg, Alumen 2kg, quicklime 30kg.These product are that class is spherical or be broken into irregular particle shape.Surface yellowish white, yellow or brown color.Matter is more crisp or firmly crisp, and section is yellow or faint yellow, and granule person matter is slightly firmly crisp.Feeble QI, lightly seasoned slightly sweetly, micro-have numb feeling in the tongue.

Be separated in the Rhizoma Pinelliae and can obtain 15 compounds, be respectively chrysophanol, succinic acid; positive Palmitic acid-1-glyceride, 3-O-(6'-O-palmityl-β-D-glucopyranosyl) bean steroid-5-alkene, hydroquinol phenol; Hydroxymethylfurfural, o-dihydroxy phenol and cupreol, daucosterol.The pharmacologic action that the Rhizoma Pinelliae possesses is relevant with above-mentioned 15 compounds.

Fructus Schisandrae Chinensis is Magnoliaceae schisandra plant Fructus Schisandrae Chinensis (Schisandrachinensis(Turcz.) Baill) or the dry mature fruit of schisandra chinensis (SchisandrasphenantheraRehd.etWils.).The former is called Radix Schisandrae Bicoloris, and the latter is Fructus Schisandrae Sphenantherae, is excellent with Radix Schisandrae Bicoloris.Fructus Schisandrae Chinensis has nourishing kidney of astringing the lung, and promote the production of body fluid arresting sweating, arresting seminal emission antidiarrheal, effect of mind tranquilizing and the heart calming.Modern technologies, to the analysis of Fructus Schisandrae Chinensis mature fruit, can isolate plurality of active ingredients.Comprise volatile ingredient, lignanoids and organic acid.Also containing citral (Citrdal), chlorophyll, sterol, vitamin C, vitamin E, saccharide, resin and tannin.Volatile ingredient has: Sesquicarene. (Sesquicarene), β-chamigrene (β-Chamigrene), α-chamigrene (α-Chamigrene), retinispora alcohol (Chamigrenol), β-bisabolence (β-Bisabolene), australene (α-Pinene), camphene (Cam-phene), nopinene (β-Pinene), myrcene (Myrcene), α-terpinene (α-Terpinene), limonene (Limonene), γ-terpinene (γ-Terpinene), p-ymene (p-Cymene), thymol methyl ether (Thymolmethylether), borneol acetate (Bornylacetate), geraniol acetate (Citronellylacetate), linalool (Linalool), terpinen-4-ols (Terpinene-4-ol), α-terpinol (α-Terpi-neol), 2-baras camphor (Borneol), citronellol (Citronellol), benzoic acid (Benzoicacid), δ-cadinene (δ-Cadinene), beta-elemene (β-Elemene), ylangene (α-Ylangene) etc.Lignanoids has: schizandrin (Schizandrin), deoxyschisandrin (Deoxyschizandrin), wuweizisu B (γ-Schizandrin), puppet-wuweizisu B (Pseudo-γ-schizandrin), schisandrin B (WuweizisuB), schisandrin C (WuweizisuC), isoschizandrin (Isoschizandrin), pregomisin (Pregomisin), neoschisandrin (Neoschizandrin), schisandrol (Schizandrol), schisandrin (SchizandrolA), schisantherin B (SchizandrolB and GomisinA), schisantherin A, second, third, fourth, penta (SchisantherinA, B, C, D, E), rubschisantherin (Rubschisantherin), schisanhenol acetate (Schisanhenolacetdte), schisanhenol B (SchisanhenolB), SALLRSIPA SAL ADNF-9 schizronol schisanhenol (Schisanhenol).Still there are Ge meter Xin (Gomisin) A, B, C, D, E, F, G, H, J, N, O, R, S, T, U; Biao Ge meter Xin (Epigomisin) O; Radix Angelicae Sinensis acyl Ge meter Xin (Angeloylgomisin) H, O, Q; Cautious each acyl Ge meter Xin (Tigloylgomisin) H, P; The different Ge meter Xin of Radix Angelicae Sinensis acyl (Angeloyisogomisin) O; Benzoyl Ge meter Xin (Benzoyl-gomisin) H, O, P, Q; The different Ge meter Xin of benzoyl (Benzoyl-isogomisin) O etc.

Pericarpium Citri Reticulatae is the dry mature skin of Rutaceae citrus plant Fructus Citri tangerinae (CitrusreticulataBlanco) and variety thereof, selects to add Pericarpium Citri Reticulatae, prescription can be made to have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm in the present invention.In usual application, Pericarpium Citri Reticulatae also can with Rhizoma Atractylodis, the same use of Cortex Magnoliae Officinalis, for middle burnt cold-damp stagnation of QI in spleen and stomach person, abdominal distention, nausea and vomiting, to have loose bowels; Use is equal to Fructus Crataegi, Massa Medicata Fermentata, for stagnation of QI due to dyspepsia, abdominal distention person; Use is equal to, for the thoracic obstruction suffocation in the chest person of losing heart with Fructus Aurantii Immaturus, Rhizoma Zingiberis Recens.Those skilled in the art according to the medication requirement of reality, can carry out plus-minus, the change of prescription according to this type of combination principle.

Fructus Mume is the dry almost ripe fruit of Rosaceae Fructus Pruni platymiscium prunus mume (sieb.) sieb.et zucc. (Prunusmume (Sieb.) Sieb.etZuce).Have and astringe the lung, astringing intestine to stop diarrhea, promote the production of body fluid, effect of relieving colic caused by ascaris.

Galla Chinensis is the insect gall on Anacardiaceae Rhus plant Fructus rhois chinensis (RhuschinensisMill.), potanin sumac (RhuspotaniniiMaxim.) or Radix Rhois Sinicae (RhuspunjabensisStew.var.sinica (Diels) Rehd.etWils.) leaf, is formed primarily of melaphis chinensis Baker (Melaphischinensis (Bell) Baker) parasitism.Also known as Conch Meretricis seu Cyclinae, hundred worm storehouses, wooden Radix Aconiti Lateralis Preparata, Folium rhois chinensis, upper Balls.There is pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating, hemostasis, effect of removing dampness sore.Modern technologies sub-argument from Galla Chinensis goes out many kinds of substance, and certified main active substances comprises: Chinese tannin, gallic acid etc.Wherein Chinese tannin is proved to be and has antibacterial, dental caries, mutation inhibiting, scavenging free radicals and antioxidative effect.

Halloysitum Rubrum is silicates mineral halloysite race halloysite, calls red symbol, red Gao Ling, HALLOYSITUM RUBRUM, laterite.Main have astringing intestine to stop diarrhea containing four water aluminium silicate, hemostasis, effect of promoting tissue regeneration and ulcer healing.In practical application, Halloysitum Rubrum also through forging, can strengthen hemostasis, antidiarrheal, astriction.The usual preparation method of Halloysitum Rubrum(calcined) is: get Halloysitum Rubrum fine powder, mix well with vinegar, rubbing, cutting, dry, and according to method of direct calcination, (during medicine calcine, the method for not isolated air is called bright satin method.) be calcined to and be popular in.Used time smashs to pieces.

Semen Myristicae is the dry kernel of Myristicaceae Nutmeg Vegetable meat Fructus Amomi Rotundus (MyristicafragransHoutt.), has warming middle-JIAO to promote flow of QI, effect of relieving diarrhea with astringents.Raw meat Fructus Amomi Rotundus oils and fats is more, have the effect of part laxation, wrap up in through face, Testa Tritici wrap up in or Pulvis Talci wrap up in after simmer system, most of oils and fats can be removed, eliminate laxation effect, more strengthen effect of relieving diarrhea with astringents.Modern technologies can isolate methyleugenol and methylisoeugenol from Semen Myristicae extract, are the effective ingredient of Semen Myristicae antidiarrheal.

The Radix Astragali is the main root of pulse family Astragalus Radix Astragali subgenus Radix Astragali (Astragalusmembranaceus (Fisch.) Bunge.), another name Radix Astragali, Radix Astragali, only mulberry, another name for Sichuan Province fat, hundred, hundred absorbent cotton, Sphallerocarpus gracilis, Herba Wedeliae Wallichii, people's ranks etc., Radix Astragali sweet in the mouth, slightly warm in nature, returns lung, spleen, liver, kidney channel.Have tonifying Qi and lifting yang, benefit defends consolidating superficial resistance, inducing diuresis to remove edema, effect of holder skin ulcer granulation promoting

Herba Ipomoeae Cairicae, is the root of Moraceae ficus species ficus simplicissima (FicushirtaVahl), calls three dragon's paws, sub-fork, Herba Fici Simplicissimae, Ficus hirta.Acrid-sweet flavor, property are flat, tepor, effect of tool strengthening the spleen and tonifying the lung, circulation of qi promoting dampness removing, relaxing muscles and tendons and activating QI and blood in the collateral.The traditional Chinese medical science of Lingnan area or ethnic groups doctor among the people are usually used in treating that insufficiency of the spleen edema, lack of appetite are unable, pulmonary tuberculosis cough, night sweat, leukorrhagia, puerperal agalactia, menoxenia, rheumatic arthralgia, the disease such as edema.

Radix Pseudostellariae is the dried root of Caryophyllaceae Pseudostellaria Pax plant Radix Ginseng (Pseudostellariaheterophylla (Miq.) PaxexPaxetHoffm.), another name Radix Ginseng, Tong Can, two batches seven, Radix Codonopsis Lanceolatae, meter Can.Radix Pseudostellariae sweet in the mouth, micro-hardship, property is put down, and returns spleen lung meridian, effect of tool tonifying QI to produce body fluid.

The Rhizoma Atractylodis Macrocephalae is the Compositae [WTBX plant Rhizoma Atractylodis Macrocephalae (AtractylodesmacrocephalaKoidz.), another name small wooden raft Ji, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, mountain Ji, poplar Serrata Ji, yellor rocket.Bitter in the mouth, sweet, warm in nature, return taste warp, tool air making-up and spleen enlivening, dampness diuretic, strengthening superficial resistance to stop perspiration, antiabortive effect.

Rhizoma Dioscoreae is the root of Dioscoreaceae plant Rhizoma Dioscoreae (CommonYamRhizome), another name Rhizoma Dioscoreae, native potato, mountain Rhizoma Dioscoreae, RHIIZOMA DIOSCOREAE fr0m Henan of China, Rhizomadioscoreae, white Rhizoma Dioscoreae, water Rhizoma Dioscoreae, hair Rhizoma Dioscoreae, light yam.Sweet in the mouth, property is put down, and returns spleen lung kidney channel, has supplementing QI and nourishing YIN, spleen reinforcing lung kidney, effect that controlling nocturnal emission with astringent drugs is only lost.

Herb Gynostemmae Pentaphylli, Cucurbitaceae Gynostemma herbaceous stem Climbing Plant Herb Gynostemmae Pentaphylli (Gynostemmapentaphyllum (Thunb.) Makino) herb, also known as: paradise grass, Gospel are careless, Chao Rencan, Herb Gynostemmae Pentaphylli, Herba Gynostemmatis, Herba Gynostemmatis, Pentapanax and gynostemma pentaphyllum makino etc.Bitter in the mouth, micro-sweet, cool in nature, return lung, spleen, kidney channel.There is invigorating the spleen and benefiting QI, preventing phlegm from forming and stopping coughing, effect of heat-clearing and toxic substances removing.

Fructus Corni, for the drying and ripening sarcocarp of Cornaceae Macrocarpium plant Fructus Corni (CornusofficinalisSieb.etZucc.), another name Fructus Corni, meat Fructus Jujubae, chicken foot, Fructus Corni, medicine Fructus Jujubae, sky wood seed, real Fructus Jujubae, another name for Sichuan Province Zao, Qi reality, Mus arrow, Fructus Corni, Fructus Corni.Sour in the mouth, (puckery), slightly warm in nature, returns Liver and kidney warp.There is liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating effect.

Cordyceps is section ergot fungus cordyceps sinensis bacterium (Cordycepssinensis(Berk.) Sacc) colonize in Hepialus larva, after larva is ossified, polypide is connected with bacterium seat and forms.Also known as Cordyceps, Cordyceps, cordyceps sinensis is the famous and precious tonic herb of China's usual one among the people.Cordyceps sweet in the mouth, property is put down, and return lung kidney channel, have kidney-reinforcing Yang-strengthening, tonifying the lung is relievingd asthma, effect of hemostasis and phlegm.

Radix Morindae Officinalis is the dry root of Rubiaceae Morinda plant Radix Morindae Officinalis (MorindaofficinalisHow), another name Radix Morindae Officinalis, Herba Morindae Parvifoliae, Caulis Gneti brill, the young intestinal of rabbit, triangle vine, bran rattan.Radix Morindae Officinalis acrid in the mouth, sweet; Slightly warm in nature.Return kidney, Liver Channel, there is reinforcing the kidney and supporting YANG, expelling wind and removing dampness, effect of strengthening the tendons and bones.

Cornu Cervi Pantotrichum, refers to the unossified and young horn with fine hair of the stag of Cervus nippon Temminck or Cervus elaphus linnaeus.Sweet in the mouth, salty, warm in nature, return kidney Liver Channel, there is invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening, adjust punching to appoint, Gu dai channel, hold in the palm effect of sore

The Cortex Eucommiae is the dry bark of the Eucommiaceae Cortex Eucommiae platymiscium Cortex Eucommiae (EucommiaulmoidesOliver), another name silk neem bark, silk flosssilk wadding skin, cotton plant skin, gum.Sweet in the mouth, warm in nature, return liver, kidney channel, tool invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect.

Semen Cuscutae, is convolvulaceous plant Cuscuta australis (CuscutaaustralisR.Br). or the dry mature seed of Semen Cuscutae (CuscutachinensisLam.), and another name Herba cuscutae reality, SEMEN CUSCUTAE, sub without ma rattan rice rice, Caulis Fibraureae.Sweet in the mouth, warm in nature, return Liver and kidney spleen channel, there is tonifying the kidney to consolidate the essence, nourishing the liver to improve visual acuity, antidiarrheal, antiabortive effect.

Radix Rehmanniae Preparata, for Scrophulariaceae Radix Rehmanniae platymiscium Radix Rehmanniae (Rehmanniaglutinosa (Gaetn.) Libosch.exFisch.etMey.) root obtains, sweet in the mouth through fumigating to black profit; Warm in nature.Return liver; Kidney channel.There is effect that moist, beneficial essence of enriching blood fills out marrow.

Radix Angelicae Sinensis, for the dry root of Umbelliferae archangel Radix Angelicae Sinensis (Angelicasinensis (Oliv.) Diels), call dryly to return, the Qin which, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, Radix Angelicae Sinensis, Radix Angelicae Sinensis body, contain that Radix Angelicae Sinensis, Radix Angelicae Sinensis are bent, Radix Angelicae Gigatis, sweet in the mouth, pungent, warm in nature, return liver heart spleen channel, having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, moisturize effect of laxation.

Radix Polygoni Multiflori Preparata is the processed product of Polygonaceae Radix Polygoni Multiflori platymiscium Radix Polygoni Multiflori (Fallopiamultiflora (Thunb.) Harald) tuber, bitter in the mouth, sweet, puckery, warm in nature.Return liver, the heart, kidney channel.There is invigorating the liver and kidney, benefiting essence-blood, black beard and hair, effect of bone and muscle strengthening.

Radix Asparagi is Liliaceae asparagus plant Radix Asparagi (Asparaguscochinchinensis(Lour.) Merr.) tuber.Another name Radix Asparagi, Radix Asparagi is cold in nature, sweet in the mouth, micro-hardship.There is replenishing YIN and removing heat, effect of lung moistening nourishing kidney.

Radix Adenophorae, for the dry root of campanulaceae Lady bell plant adenophora tetraphylla (Adenophoratetraphylla (Thunb.) Fisch.) or Radix Adenophorae (Radix Glehniae) (AdenophorastrictaMiq.), adenophora tetraphylla originates in northeast, the Inner Mongol, Hebei, Shanxi, Shandong, East China, Guangdong, Guangxi, Yunnan, Sichuan, Guizhou; Radix Adenophorae (Radix Glehniae) originates in Jiangsu, Anhui, Zhejiang, Jiangxi, Hunan.Sweet in the mouth, cold nature, returns lung stomach warp, has nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, reduce phlegm, effect of QI invigorating.

Specific embodiment

The present invention is further illustrated below by way of several embodiment.Should be appreciated that cited all embodiments are help skilled in the art to understand and implement the present invention, not any type of any limitation of the invention.All simple modifications of carrying out on basis of the present invention and adjustment, and raw material is wherein carried out equivalent or equivalent replacement, and fail to produce new substantive distinguishing features and marked improvement, all should within protection scope of the present invention.

Embodiment 1 composition prescription example

Below provide several example prescription, and indicate each prescription scope of application and object.It is noted that listed prescription is not any restriction to prescription composition, be only the use of concrete example explanation.Those skilled in the art can be different according to the card shape of disease indicia, and the body constitution difference of patient adjusts prescription, and these adjustment should be included within protection scope of the present invention equally.

Prescription 1

Rhizoma Polygonati 45g Rhizoma Acori Calami 25g Fructus Chebulae 17g Rhizoma Acori Graminei 35g

Fructus Terminaliae Billericae 45g east Fructus Fragariae Ananssae 23g Stigma Croci 5g CATECHU 5g

Prescription 2

Rhizoma Polygonati 45g Rhizoma Acori Calami 25g Fructus Chebulae 17g Rhizoma Acori Graminei 35g

Fructus Terminaliae Billericae 45g east Fructus Fragariae Ananssae 23g Stigma Croci 5g CATECHU 5g

Sedumviviparum 29g

Prescription 3

Rhizoma Polygonati 45g Rhizoma Acori Calami 25g Fructus Chebulae 17g Rhizoma Acori Graminei 35g

Fructus Terminaliae Billericae 45g east Fructus Fragariae Ananssae 23g Stigma Croci 5g CATECHU 5g

Sedumviviparum 29g Herba Gnaphalii Affinis 34g

Prescription 4

Rhizoma Polygonati 37g Rhizoma Acori Calami 20g Fructus Chebulae 10g Rhizoma Acori Graminei 35g

Fructus Terminaliae Billericae 45g east Fructus Fragariae Ananssae 23g Stigma Croci 5g CATECHU 5g

Sedumviviparum 29g Herba Anaphalidis Lacteae 30g

Prescription 5

Rhizoma Polygonati 25g Rhizoma Acori Calami 22g Fructus Chebulae 12g Rhizoma Acori Graminei 32g

Fructus Terminaliae Billericae 41g east Fructus Fragariae Ananssae 20g Stigma Croci 3g CATECHU 6g

Sedumviviparum 24g Herba Gnaphalii Affinis 28g Radix Astragali 5g Herba Ipomoeae Cairicae 3g

Prescription 6

Rhizoma Polygonati 25g Rhizoma Acori Calami 22g Fructus Chebulae 12g Rhizoma Acori Graminei 32g

Fructus Terminaliae Billericae 41g east Fructus Fragariae Ananssae 20g Stigma Croci 3g CATECHU 6g

Sedumviviparum 24g Herba Gnaphalii Affinis 28g Rhizoma Pinelliae Preparatum 5g Fructus Schisandrae Chinensis 5g

Pericarpium Citri Reticulatae 7g

Prescription 7

Rhizoma Polygonati 25g Rhizoma Acori Calami 22g Fructus Chebulae 12g Rhizoma Acori Graminei 32g

Fructus Terminaliae Billericae 41g east Fructus Fragariae Ananssae 20g Stigma Croci 3g CATECHU 6g

Sedumviviparum 24g Herba Anaphalidis Lacteae 28g Cordyceps 10g

Prescription 8

Rhizoma Polygonati 25g Rhizoma Acori Calami 15g Fructus Chebulae 12g Rhizoma Acori Graminei 16g

Fructus Terminaliae Billericae 27g east Fructus Fragariae Ananssae 10g Stigma Croci 4g CATECHU 4g

Sedumviviparum 8g Herba Gnaphalii Affinis 18g Semen Cuscutae 4g Radix Polygoni Multiflori Preparata 2g

Embodiment 2 preparation example

Example 1 Powder preparation

1. compositions described in prescription 4 in embodiment 1 is provided.

2. mix and get final product after each component porphyrize.

Example 2 Powder preparation

1. compositions described in prescription 6 in embodiment 1 is provided.

2. mix and get final product after each component porphyrize.

Example 3 oral liquid formulations

1. compositions described in prescription 2 in embodiment 1 is provided.

2. after each component porphyrize, with water soaking after at least 2 hours, then 2 times are decocted, each 2 hours.Each decoction terminates equal collecting by filtration decoction liquor.

3. merge decoction liquor, concentrating under reduced pressure, cross leaching clear liquid.

4. get whitish honey 10g, add water and be dissolved into honey in right amount, 3. will dilute by middle clear liquid honey, and stir, to obtain final product.

Example 4 hard capsule preparation

1. compositions described in prescription 6 in embodiment 1 is provided.

2. after each component porphyrize, with 95% soak with ethanol at least 14h, so soak 3-4 time light to soak color, merge soak, filtration.

3. after filter, liquid concentrating under reduced pressure makes dry extract, adds appropriate fluidizer or lubricant, and as magnesium stearate, Pulvis Talci etc., mixing, sends in coating pan, sprayed into by wetting agent, make the moistening bonding granulating of powder as ethanol or water with vaporific, continues rolling to particle drying.

4. get medicinal hollow capsule, be placed on capsule filling plate, incite somebody to action the particles filled capsule that enters 3., sealed capsule.

Should be noted, above preparation example is all be based upon on a small amount of basis made.When needs are produced in enormous quantities, in prescription, each major amount answers equal proportion to expand, and adopts suitable suitability for industrialized production equipment simultaneously, comprises liquid-filling machine, powder compressing machine, capsule loader, seed-coating machine etc. as used.

Embodiment 3 animal effect experiment

1, immunity myasthenia gravis mouse model is set up

With California electric eel electric organ AChR(T.CalifornicaAChR) prepare antigen Emulsion with complete Freund's adjuvant (CFA) 1:2 ratio.Get C57BL/6 mice (about body weight 16g), by antigen emulsion in the two metapedes pad of mice, root of the tail portion, back multi-point injection, injection volume is 100 μ L.Add injection once after 1d, add 2 times altogether.Observe mice active situation, occurring the movable unable symptom of afterbody in 9d, there is two hind limb weakness symptom in 10d, thinks that modeling is successful.

Medicine shown in prescription 1,4,6,7 is used 0.5% sodium carboxymethyl cellulose suspendible respectively, makes the mass body volume concentrations of medicine be 71mg/mL;

2, grouping and experiment

Model mice is divided into 6 groups at random, point vehicle control group, positive controls, Chinese drug-treated group 1-4 group, often organizes 10.Separately getting healthy mice 10 is Normal group.Positive control medicine is dexamethasone, gavage (0.2mg/kg body weight), and once a day, Chinese medicine 1-4 group is the suspension of medicine shown in prescription 1,4,6,7, and gavage amount is 1ml/kg body weight, once a day; Negative control group is isopyknic 0.5% carboxymethylcellulose sodium solution gavage with medicine group, and once a day, adjuvant group is isopyknic complete Freund's adjuvant gavage with medicine group, once a day.After 28d, each group mice stops administration, continues to observe 28d.

3, result

(1) in the front 28d of successive administration, Mouse Weight situation of change

Weigh each group of mice 0d, 7d, 14d, 21d, 28d body weight, record average weight (unit: g).

* note: adjuvant group has a dead mouse in 15d, 26d has two dead mouses.

After (2) 28d complete last administration, stop administration, the body weight change situation of mice

Weigh each group of mice 35d, 42d, 49d, 56d body weight, record average weight (unit: g).

* note: positive group has a dead mouse with 37d, and 46d has three dead mouses, and 52d has two dead mouses.Amount to 6 dead mouses, mortality rate 60%.

* note: adjuvant group has a dead mouse in 33d, 34d has three dead mouses, and 42d has two dead mouses, last 1 dead mouse of 45d (body weight is 8.0g).Amount to 10 dead mouses, mortality rate 100%.

Conclusion:

1. the experimental mice of non-drug treatment passes aggravation in time, causes masticatory atonia gradually and is difficult to feed, causing weight loss; There is dead example in the state of an illness comparatively severe one.

2. positive group is given and dexamethasone in treatment; alleviate the condition of illness being difficult to take food that mice causes because of myasthenia; thus can partly recover normal activity diet; along with treatment continue carry out; body weight increases to some extent, when after stopping drug treatment, again occurs weight loss; and there is dead individuals, illustrate that the dexamethasone drug treatment continuing 1 month fails to treat mice myasthenia gravis at all.

3. Chinese drug-treated group is with Chinese medicine composition administration provided by the invention, onset is slower, but drug effect is comparatively lasting, whole structure is organized basically identical with the positive, substantially return to the weight levels of normal mouse in 28d, after stopping administration, do not occur dead individuals, body weight does not have obvious decline yet, kept stable.

This experimental result shows, Chinese medicine composition provided by the invention can improve the symptom of mice myasthenic model of CNS dysfunction, simultaneously compared with dexamethasone in treatment, has the advantage of lasting medicine.The reason of lasting medicine may be, Chinese medicine composition provided by the invention has rebuild the impaired immune system of mice.

Claims (9)

1. a Chinese medicine composition, it is characterized in that, raw material comprises Rhizoma Polygonati 1-45 part, Rhizoma Acori Calami 1-25 part, Fructus Chebulae 1-37 part, Rhizoma Acori Graminei 1-45 part, Fructus Terminaliae Billericae 1-45 part, east Fructus Fragariae Ananssae 1-23 part, Stigma Croci 1-10 part, and is selected from least one in CATECHU 1-15 part, Sedumviviparum 1-29 part, Herba Gnaphalii Affinis 1-34 part.

2. compositions according to claim 1, it is characterized in that, raw material comprises Rhizoma Polygonati 1-45 part, Rhizoma Acori Calami 1-25 part, Fructus Chebulae 1-37 part, Rhizoma Acori Graminei 1-45 part, Fructus Terminaliae Billericae 1-45 part, east Fructus Fragariae Ananssae 1-23 part, Stigma Croci 1-10 part, and is selected from least two kinds in CATECHU 1-15 part, Sedumviviparum 1-29 part, Herba Gnaphalii Affinis 1-34 part.

3. compositions according to claim 1, it is characterized in that, raw material comprises Rhizoma Polygonati 1-45 part, Rhizoma Acori Calami 1-25 part, Fructus Chebulae 1-37 part, Rhizoma Acori Graminei 1-45 part, Fructus Terminaliae Billericae 1-45 part, east Fructus Fragariae Ananssae 1-23 part, Stigma Croci 1-10 part, CATECHU 1-15 part, Sedumviviparum 1-29 part, Herba Gnaphalii Affinis 1-34 part.

4., according to one of any described compositions of claim 1-3, it is characterized in that, raw material also comprises at least one and is selected from the Radix Astragali, Herba Ipomoeae Cairicae, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Herb Gynostemmae Pentaphylli.

5., according to one of any described compositions of claim 1-3, it is characterized in that, raw material also comprises at least one and is selected from Rhizoma Pinelliae Preparatum, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae, Fructus Mume, Galla Chinensis, Halloysitum Rubrum, Semen Myristicae.

6., according to one of any described compositions of claim 1-3, it is characterized in that, raw material also comprises at least one and is selected from Fructus Corni, Cordyceps, Radix Morindae Officinalis, Cornu Cervi Pantotrichum, the Cortex Eucommiae, Semen Cuscutae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Polygoni Multiflori Preparata, Radix Asparagi, Radix Adenophorae.

7. compositions according to claim 3, is characterized in that each raw material weight consumption is Rhizoma Polygonati 3-38 part, Rhizoma Acori Calami 1-20 part, Fructus Chebulae 1-28 part, Rhizoma Acori Graminei 1-37 part, Fructus Terminaliae Billericae 1-40 part, east Fructus Fragariae Ananssae 1-18 part, Stigma Croci 1-8 part, CATECHU 1-10 part, Sedumviviparum 1-25 part, Herba Gnaphalii Affinis 1-30 part.

8. compositions according to claim 7, is characterized in that each raw material weight consumption is Rhizoma Polygonati 8-30 part, Rhizoma Acori Calami 5-17 part, Fructus Chebulae 5-20 part, Rhizoma Acori Graminei 6-28 part, Fructus Terminaliae Billericae 15-31 part, east Fructus Fragariae Ananssae 3-15 part, Stigma Croci 2-6 part, CATECHU 2-8 part, Sedumviviparum 1-10 part, Herba Gnaphalii Affinis 1-25 part.

9. a Chinese medicine preparation, is characterized in that, the compositions provided by claim 1-3 any one, and pharmaceutically acceptable adjuvant or carrier are made optionally to comprise at least one.