CN103977162A - Traditional Chinese medicament for treating gestational vulvareczema and preparation method thereof - Google Patents
Traditional Chinese medicament for treating gestational vulvareczema and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicament for treating gestational vulvareczema and a preparation method thereof. The traditional Chinese medicament is prepared from the following raw medicinal materials in parts by weight: 6-14 parts of dysosma versipellis, 6-14 parts of backleaf mallotus root, 20-28 parts of chushan lip-fern herb, 6-14 parts of Japanese banana root, 6-14 parts of silkworm larva, 26-34 parts of serissa serissoides, 4-8 parts of alum, 6-14 parts of goat-ear elecampane, 26-34 parts of angelica root, 4-8 parts of schizonepeta and 11-19 parts of suberect spatholobus stem. The traditional Chinese medicament has the characteristics of good effect, light adverse response and high safety when being used for treating gestational vulvareczema.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine for the treatment of trimester of pregnancy vulval eczema and preparation method thereof.
background technology
Vulval eczema is a kind of common non-infectious dermatosis; pathological changes is confined to perineum and clitoris more, also even have spread to buttocks, can there is erythema, erythema, erosion in part; ooze out, incrustation, desquamation; the course of disease is long, and perineum surrounding skin often thickens, and color is greyish white or dark red; coarse; so that chap, ooze out, pruritus, repeatedly to show effect be main feature, any age all can fall ill.Pathogenesis, vulval eczema is mainly a kind of delayed allergy being caused by the inside and outside motivating factor of complexity.But its cause of disease and allergenic character, immunoreactive feature and whether relevant with the late response of IgE mediation, illustrate not yet completely.
Pregnancy period hormone in vivo level produces great variety, local nerve function sensitive improves thereupon, oneself confirms that the raising of local nerve function sensitive occurs clearly relevant to vulval eczema Weidner etc., its inherent approach is: nerve fiber and mastocyte are contacted directly by Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, can make mast cell degranulation releasing histamine, cause pruritus.So be different from other allergic eczemas, even if pregnancy period eczema is removed some sensitizing factor, eczema pathological changes can not disappear very soon, so existing eczema treatment means are for pregnancy period vulval eczema effect unsatisfactory.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, and a kind of Chinese medicine for the treatment of trimester of pregnancy vulval eczema that a kind of curative effect is affirmed and side effect is little and preparation method thereof is provided.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine for trimester of pregnancy vulval eczema, made by the crude drug of following weight portion:
Radix et Rhizoma Dysosmatis 6-14 part, notopodium root 6-14 part, Herba Cheilanthes chusane 20-28 part, Radix Musae 6-14 part, Bombyx Batryticatus 6-14 part, Radix Serissae 26-34 part, Alumen 4-8 part, Herba Inulae cappae 6-14 part, Radix Angelicae Dahuricae 26-34 part, Herba Schizonepetae 4-8 part, Caulis Spatholobi 11-19 part.
Preferably, the Chinese medicine of above-mentioned treatment trimester of pregnancy vulval eczema, made by the crude drug of following weight portion:
Radix et Rhizoma Dysosmatis 8-12 part, notopodium root 8-12 part, Herba Cheilanthes chusane 22-26 part, Radix Musae 8-12 part, Bombyx Batryticatus 8-12 part, Radix Serissae 28-32 part, Alumen 5-7 part, Herba Inulae cappae 8-12 part, Radix Angelicae Dahuricae 28-32 part, Herba Schizonepetae 5-7 part, Caulis Spatholobi 13-17 part.
Preferred, the Chinese medicine of above-mentioned treatment trimester of pregnancy vulval eczema, made by the crude drug of following weight portion:
10 parts of Radix et Rhizoma Dysosmatiss, 10 parts of notopodium roots, 24 parts of Herba Cheilanthes chusanes, 10 parts of Radix Musae, 10 parts of Bombyx Batryticatus, 30 parts of Radix Serissae, 6 parts of Alumens, 10 parts of Herba Inulae cappaes, 30 parts of the Radixs Angelicae Dahuricae, 6 parts of Herba Schizonepetae, 15 parts of Caulis Spatholobis.
The Chinese medicine of above-mentioned treatment trimester of pregnancy vulval eczema, the dosage form of described Chinese medicine is external preparation.Be preferably external-use lotion.
The preparation method of the Chinese medicine of above-mentioned treatment trimester of pregnancy vulval eczema, comprises the steps:
(1) take various raw materials according to required weight portion;
(2) Herba Cheilanthes chusane, Radix Serissae, Herba Inulae cappae, the Radix Angelicae Dahuricae, Herba Schizonepetae are ground into coarse powder, vapor distillation extracts volatile oil, and for subsequent use after collecting, and the medicinal residues after extraction are for subsequent use after mixing;
(3) by the medicinal residues after Radix et Rhizoma Dysosmatis, notopodium root, Radix Musae, Bombyx Batryticatus, Caulis Spatholobi and above-mentioned distillating extracting oil, decoct with water extraction secondary, adding for the first time injection volume 4-6 times of water gaging decocts 2 hours, adding for the second time injection volume 3-5 times of water gaging decocts 1.0 hours, collecting decoction, add again the aqueous solution after above-mentioned distillation, filter; It is 1.09～1.13 concentrated solution that 60 DEG C of filtrates are concentrated into relative density, lets cool, and adds ethanol to reaching 65-75% containing alcohol amount, stirs evenly, and 0～5 DEG C of standing cold preservation 24 hours, filters; It is 1.07～1.12 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, adds the water dilution of equivalent, stir evenly, then 2～5 DEG C of standing cold preservation 24 hours, filter;
(4) filtrate adds above-mentioned Alumen fine powder, with adding with stirring; And regulate pH value to 4.5～6.0, and add water and be adjusted to 1000 weight portions, filter, sterilizing, to obtain final product.
Preferably, in the preparation method of the Chinese medicine of above-mentioned treatment trimester of pregnancy vulval eczema, in described step (3), add for the first time 5 times of water gagings of injection volume and decoct 2 hours, add for the second time 4 times of water gagings of injection volume and decoct 1.0 hours.
Preferably, in the preparation method of the Chinese medicine of above-mentioned treatment trimester of pregnancy vulval eczema, in described step (3), add ethanol to reaching 70% containing alcohol amount.
The usage and dosage of lotion of medication of the present invention is: with lotion of medication of the present invention (get this product 20ml and add warm water to 200ml, mix) the scouring pudendum of 10% concentration; Or the lotion of medication of the present invention of 10% concentration is delivered to vagina deep washing vagina with irrigator.2-3 time on the one 7 days is a course for the treatment of.
The present invention treats in the prescription of Chinese medicine of trimester of pregnancy vulval eczema,
Radix et Rhizoma Dysosmatis is Berberidaceae Dysosma plant Radix et Rhizoma Dysosmatis Dysosma pleiantha (Hance) Woods.[Podophyllum pleiantha Hance] or Rhizoma et Radix Dysosmae Veitchii D. versipellis (Hance) M. Cheng, be used as medicine with root stock.Sweet, bitter in the mouth are cool.Enter lung; Liver Channel.Heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.Cure mainly: venom, traumatic injury; Worm venom is controlled in external, and carbuncle furuncle is swollen, lymphadenitis, parotitis, breast carcinoma.
Notopodium root is the root of Euphorbiaceae Cortex Alchorneae Davidii platymiscium red back of the body Cortex Alchorneae Davidii Alchornea trewioides (Benth.) Muell.-Arg..Sweet, cool.Return bladder; Large intestine; Lung meridian.Clearing away heat-damp and promoting diuresis, dissipating blood stasis hemostasis.For dysentery, dysuria, hematuria, lithangiuria, red collapsing, leucorrhea, lumbago and skelalgia, treating swelling and pain by traumatic injury; Traumatic hemorrhage is controlled in external, urticaria, eczema.
Herba Cheilanthes chusane is Sinopteridaceae vegetable hair axle Herba pteridii latiusculi Cheilosoria chusana (Hook.) the Ching et Shing [herb of Cheilanthes chusana Hook. of cracking rice.Micro-hardship, cold, nontoxic.Return kidney; Bladder; Large intestine channel." Hunan medicine will ": " antidiarrheal profit dung; Heat-clearing and toxic substances removing, styptic powder blood.Control dysentery, urine pain, foot is soft unable, fever with pantalgia, laryngalgia, venom, carbuncle furuncle and phyma scrofula."
Radix Musae is the rhizome of Musaceae plant Musa basjoo Sieb. Et Zucc. Musa basjoo Sieb. Et Zucc..Sweet in the mouth; Cold in nature, return through stomach; Spleen; Liver Channel.Thermal detoxification; Quench the thirst; Diuresis.Main calentura; Unhappiness is quenched one's thirst; Carbuncle furunculosis; Erysipelas; Metrorrhagia; Stranguria with turbid discharge; Edema; Beriberi.
Larva Beauveria bassiana (Bals.) Vaillant. that Bombyx Batryticatus is Bombycidae animal bombyx mori infects the ossified Scorpio of muscardine.Acrid in the mouth; Salty; Property is put down, and returns liver; Lung; Stomach warp.Expelling wind and relieving convulsion; Dissipating phlegm and resolving masses; Resolving toxin and disinhibiting the throat.Main infantile convulsion is twitched; Middle air port eye is oblique; Migraine and general headache; Laryngopharynx swelling and pain; Scrofula; Mumps; Rubella; Sore.
Radix Serissae is the herb strain of dicotyledon medicine Maguireothamnus speciosus Radix Serissae or Serissa foetida.Latin plant is by name: 1.Serissa serissoides (DC.) Druce2.Serissa japonica (Thunb.) Thunb. [Lycium japonicum Thunb.; Serissa foetida (L.F.) Comn].Toil, cool.Liver; Spleen channel.Dispel the wind; Dampness removing; Heat clearing away; Removing toxic substances.Main flu; Icterohepatitis; Oedema due to nephritis; Cough; Laryngalgia; Keratitis; Intestinal inflammation; Dysentery; Lumbago and skelalgia; Hemoptysis; Hematuria; Women's amenorrhea; Leucorrhea; Infantile malnutrition; Infantile convulsion; Acute toothache; Swollen ulcer drug; Traumatic injury.
Alumen claims again Alumen, Alumen, for Sulfates mineral alunite refines and makes through processing.Dried Alumen: get clean Alumen, be calcined to crisp according to method of direct calcination (appendix II D).Sour, puckery, cold.Return lung, spleen, liver, large intestine channel.External removing toxic substances parasite killing, dampness removing to stop itchin; Hemostasis antidiarrheal for oral administration, dispels wind-phlegm.External treatment is for eczema, scabies, Ting discharging ear; Take orally for incessant chronic diarrhea, have blood in stool, metrorrhagia, epilepsy is gone mad.
Herba Inulae cappae is the herb of feverfew Herba Inulae cappae.Latin plant animal mineral name: Inula cappa (Buch.-Ham.) DC. acrid in the mouth; Sweet; Micro-hardship; Warm in nature.Enter liver, lung, spleen, all warps of stomach, expelling wind and cold; Circulation of qi promoting dampness removing; Removing toxic substances and promoting subsidence of swelling.Main anemofrigid cold; Cough; Rheumatic arthralgia; Let out dysentery; Hepatitis; Mastitis; Hemorrhoid; Eczema; Scabies
The Radix Angelicae Dahuricae is plant Radix Angelicae Dahuricae Angelica dahurica (Fisch.ex Hoffm.) the Benth. et Hook.f. of umbellate form section or Radix angelicae dahuricae Angelica dahurica(Fisch.ex Hoffm.) Benth.et Hook.f. var.formosana(Boiss.) dry root of Shan et Yuan.Pungent, temperature.Return stomach, large intestine, lung meridian.Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.
Herba Schizonepetae (Nepeta cataria L.), acrid in the mouth, warm in nature, enter liver lung, warp, nontoxic, faint scent is dense.Herba Schizonepetae is diaphoresis, and antipyretic is one of conventional medical herbs of China, can town expectorant, dispel the wind, removing heat from blood.Control influenza, the diaphoresis of headache cold and heat, vomiting.
Caulis Spatholobi, this product is the dry rattan of leguminous plant spatholobus suberectus (Radix seu Caulis Verntilaginis Leiocarpae, SANYE Caulis Spatholobi, nine layers of wind) Spatholobus suberectus Dunn.Autumn, two seasons of winter gather, and remove branch and leaf, and section, dries.The promoting the circulation of blood of enriching blood, nourishes blood and blood, the meridian dredging.
Composition principle: vulval eczema, the traditional Chinese medical science thinks that its cause of disease is wind, wet, the pathogenic heat skin of being detained, or wind syndrome due to blood-deficiency dryness-transformation, due to failure of skin and muscle to be nourished.Mostly choose " removing dampness removing toxic substances " medicines such as Rhizoma Smilacis Glabrae, Rhizoma Coptidis, Cortex Phellodendri, Herba Taraxaci, Alumen, Radix Sophorae Flavescentis, Cortex Dictamni, or Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra " blood enriching and dryness moistening " Drug therapy.But pregnancy period vulval eczema is because pregnancy period hormone in vivo level produces great variety, the raising of local nerve function sensitive and pregnancy period are used dispelling the damp pathogen with drugs of bitter in taste and cold in nature medicine also easily to cause local skin to lose and support atrophy thereupon, and blood circulation promoting medicine too much can cause again rustic of local blood capillary to wait untoward reaction.Inventor's clinical research finds that pregnancy period local nerve function hypersensitivity is also relevant with the latent network of cold-evil, both can illustrate, Pregnant Women, under cold stimulation, can bring out vulval eczema recurrence.
Compared with prior art, the present invention has following characteristics:
In prescriptions of Chinese medicine of the present invention, getting Radix Serissae, Herba Cheilanthes chusane, Radix Angelicae Dahuricae three is monarch, and pudendum is the place of liver channel of foot-Jueyin, kidney meridian and stomach channel of foot-Yang-ming process, vulval eczema is many to be caused by stagnated heat of liver channel, thus in the present invention, get Radix Serissae toil, cool, return liver, spleen channel, dispel the wind; Dampness removing; Heat clearing away; Removing toxic substances.Herba Cheilanthes chusane is returned kidney; Bladder; Large intestine channel, heat-clearing and toxic substances removing.The Radix Angelicae Dahuricae is pungent, and temperature enters lung meridian, loose wind dehumidifying.Three share, clearing away heat and expelling wind dampness removing.Radix et Rhizoma Dysosmatis, notopodium root, Radix Musae, Herba Inulae cappae heat-clearing and toxic substances removing removing heat from blood, Bombyx Batryticatus, Herba Schizonepetae are dispeled the wind; Alumen dampness, Caulis Spatholobi is supported and blood dredging collateral, makes blood wind from going out.All medicines share, and play altogether heat-clearing and toxic substances removing, and effect of expelling wind and removing dampness, for pregnancy women vulval eczema.
Radix et Rhizoma Dysosmatis in prescription of the present invention, notopodium root, Herba Cheilanthes chusane, Radix Musae, Radix Serissae are partially cold, and Herba Inulae cappae, the Radix Angelicae Dahuricae, Herba Schizonepetae, Caulis Spatholobi are warm in nature, and full side is in harmonious proportion together, and cold and heat offset, and it is gentle that the property of medicine becomes, and do not hinder anemia of pregnant woman's skin.
Clinical research result shows, the present invention treats the treatment cure rate, total effective rate of the Chinese medicine of trimester of pregnancy vulval eczema apparently higher than matched group, and the incidence rate of untoward reaction is low, illustrate that treatment by Chinese herbs pregnancy period vulval eczema of the present invention has effective, untoward reaction is light, the higher feature of safety.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Prescription:
Radix et Rhizoma Dysosmatis 10g, notopodium root 10g, Herba Cheilanthes chusane 24g, Radix Musae 10g, Bombyx Batryticatus 10g, Radix Serissae 30g, Alumen 6g, Herba Inulae cappae 10g, Radix Angelicae Dahuricae 30g, Herba Schizonepetae 6g, Caulis Spatholobi 15g.
Preparation method:
(1) take various raw materials according to required weight portion;
(2) Herba Cheilanthes chusane, Radix Serissae, Herba Inulae cappae, the Radix Angelicae Dahuricae, Herba Schizonepetae are ground into coarse powder, vapor distillation extracts volatile oil, and for subsequent use after collecting, and the medicinal residues after extraction are for subsequent use after mixing;
(3) by the medicinal residues after Radix et Rhizoma Dysosmatis, notopodium root, Radix Musae, Bombyx Batryticatus, Caulis Spatholobi and above-mentioned distillating extracting oil, decoct with water extraction secondary, adding for the first time 5 times of water gagings of injection volume decocts 2 hours, adding for the second time 4 times of water gagings of injection volume decocts 1.0 hours, collecting decoction, add again the aqueous solution after above-mentioned distillation, filter; It is 1.09～1.13 concentrated solution that 60 DEG C of filtrates are concentrated into relative density, lets cool, and adds ethanol to reaching 70% containing alcohol amount, stirs evenly, and 0～5 DEG C of standing cold preservation 24 hours, filters; It is 1.07～1.12 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, adds the water dilution of equivalent, stir evenly, then 2～5 DEG C of standing cold preservation 24 hours, filter;
(4) filtrate adds above-mentioned Alumen fine powder, with adding with stirring; And regulate pH value to 4.5～6.0, and add water and be adjusted to 1000ml, filter, sterilizing, to obtain final product.
Embodiment 2
Radix et Rhizoma Dysosmatis 8g, notopodium root 12g, Herba Cheilanthes chusane 22g, Radix Musae 12g, Bombyx Batryticatus 8g, Radix Serissae 32g, Alumen 5g, Herba Inulae cappae 8g, Radix Angelicae Dahuricae 32g, Herba Schizonepetae 5g, Caulis Spatholobi 17g.
Preparation method:
(1) take various raw materials according to required weight portion;
(2) Herba Cheilanthes chusane, Radix Serissae, Herba Inulae cappae, the Radix Angelicae Dahuricae, Herba Schizonepetae are ground into coarse powder, vapor distillation extracts volatile oil, and for subsequent use after collecting, and the medicinal residues after extraction are for subsequent use after mixing;
(3) by the medicinal residues after Radix et Rhizoma Dysosmatis, notopodium root, Radix Musae, Bombyx Batryticatus, Caulis Spatholobi and above-mentioned distillating extracting oil, decoct with water extraction secondary, adding for the first time 6 times of water gagings of injection volume decocts 2 hours, adding for the second time 3 times of water gagings of injection volume decocts 1.0 hours, collecting decoction, add again the aqueous solution after above-mentioned distillation, filter; It is 1.09～1.13 concentrated solution that 60 DEG C of filtrates are concentrated into relative density, lets cool, and adds ethanol to reaching 65% containing alcohol amount, stirs evenly, and 0～5 DEG C of standing cold preservation 24 hours, filters; It is 1.07～1.12 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, adds the water dilution of equivalent, stir evenly, then 2～5 DEG C of standing cold preservation 24 hours, filter;
(4) filtrate adds above-mentioned Alumen fine powder, with adding with stirring; And regulate pH value to 4.5～6.0, and add water and be adjusted to 1000ml, filter, sterilizing, to obtain final product.
Embodiment 3
Radix et Rhizoma Dysosmatis 12g, notopodium root 8g, Herba Cheilanthes chusane 26g, Radix Musae 8g, Bombyx Batryticatus 12g, Radix Serissae 28g, Alumen 7g, Herba Inulae cappae 12g, Radix Angelicae Dahuricae 28g, Herba Schizonepetae 7g, Caulis Spatholobi 17g.
Preparation method:
(1) take various raw materials according to required weight portion;
(2) Herba Cheilanthes chusane, Radix Serissae, Herba Inulae cappae, the Radix Angelicae Dahuricae, Herba Schizonepetae are ground into coarse powder, vapor distillation extracts volatile oil, and for subsequent use after collecting, and the medicinal residues after extraction are for subsequent use after mixing;
(3) by the medicinal residues after Radix et Rhizoma Dysosmatis, notopodium root, Radix Musae, Bombyx Batryticatus, Caulis Spatholobi and above-mentioned distillating extracting oil, decoct with water extraction secondary, adding for the first time 4 times of water gagings of injection volume decocts 2 hours, adding for the second time 5 times of water gagings of injection volume decocts 1.0 hours, collecting decoction, add again the aqueous solution after above-mentioned distillation, filter; It is 1.09～1.13 concentrated solution that 60 DEG C of filtrates are concentrated into relative density, lets cool, and adds ethanol to reaching 75% containing alcohol amount, stirs evenly, and 0～5 DEG C of standing cold preservation 24 hours, filters; It is 1.07～1.12 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, adds the water dilution of equivalent, stir evenly, then 2～5 DEG C of standing cold preservation 24 hours, filter;
(4) filtrate adds above-mentioned Alumen fine powder, with adding with stirring; And regulate pH value to 4.5～6.0, and add water and be adjusted to 1000ml, filter, sterilizing, to obtain final product.
Embodiment 4
Radix et Rhizoma Dysosmatis 6g, notopodium root 14g, Herba Cheilanthes chusane 20g, Radix Musae 14g, Bombyx Batryticatus 6g, Radix Serissae 34g, Alumen 4g, Herba Inulae cappae 14g, Radix Angelicae Dahuricae 26g, Herba Schizonepetae 8g, Caulis Spatholobi 11g.
Preparation method is with embodiment 1.
Embodiment 5
Radix et Rhizoma Dysosmatis 14g, notopodium root 6g, Herba Cheilanthes chusane 28g, Radix Musae 6g, Bombyx Batryticatus 14g, Radix Serissae 26g, Alumen 8g, Herba Inulae cappae 6g, Radix Angelicae Dahuricae 34g, Herba Schizonepetae 4g, Caulis Spatholobi 19g.
Preparation method is with embodiment 1.
The preparation of embodiments of the invention l has been carried out to clinical pharmacodynamics test, and result is as follows:
1, physical data
Case selection: 160 exception vaginal eczema patients are all from this Out-patient Department, age 21-44 year, pregnant all 4-38 weeks, be divided at random matched group and treatment group, wherein matched group 80 examples, 27.84 ± 10.52 years old mean age, pregnant Zhou Pingjun 12.34 ± 12.91, treatment group 80 examples, 28.13 ± 11.23 years old mean age, pregnant Zhou Pingjun 13.17 ± 11.48.Two groups of cases difference not statistically significant (P>0.05) on age, pregnant week distribute, has comparability.
2, diagnostic criteria
Diagnostic criteria: " traditional Chinese medical science disease Standardization of diagnosis and curative effect " that vulval eczema diagnostic criteria is promulgated by State Administration of Traditional Chinese Medicine carried out.Symptom: perineum humidity, pruritus, twinge discomfort, night more so.Training checks: pimple, erythema, erosion, sepage appear in acute person's perineum place; Chronic person's perineum place skin is canescence, thickens chap, is lichenification and the shallow breach of radial table.
3, Therapeutic Method
Matched group rinses with 1:1000 potassium permanganate, and each 5 minutes, every day 3 times, every day 3 times.It within 7 days, was 1 course for the treatment of.
Treatment group is cleaned pudendum with the lotion of medication of the present invention (get this product 20ml and add warm water to 200ml, mix) of 10% concentration; Each 5 minutes, 3 times on the one 7 days was a course for the treatment of.
4, criterion of therapeutical effect:
Recovery from illness: clinical symptoms, sign disappear; Effective: clinical symptoms, sign turn for the better by and large, vulval eczema scope is dwindled more than 1/2; Effective: clinical symptoms, sign alleviate, vulval eczema scope is dwindled less than 1/2 before treating; Invalid: clinical symptoms, sign, vulval eczema scope are unchanged.
Statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t.
5, result.
The results are shown in Table 1.
Note: compared with matched group, * * P < O.01.
Two groups of Comprehensive Clinical curative effects comparison: treatment group cure rate and aggregate efficiency rate and matched group difference are extremely obviously shown (P<O. 01).
6, untoward reaction
Two groups of patients all do not have obvious adverse reaction report.
Claims (8)
1. a Chinese medicine for the treatment of trimester of pregnancy vulval eczema, is characterized in that, is made up of the crude drug of following weight portion:
Radix et Rhizoma Dysosmatis 6-14 part, notopodium root 6-14 part, Herba Cheilanthes chusane 20-28 part, Radix Musae 6-14 part, Bombyx Batryticatus 6-14 part, Radix Serissae 26-34 part, Alumen 4-8 part, Herba Inulae cappae 6-14 part, Radix Angelicae Dahuricae 26-34 part, Herba Schizonepetae 4-8 part, Caulis Spatholobi 11-19 part.
2. the Chinese medicine for the treatment of trimester of pregnancy vulval eczema according to claim 1, is characterized in that, is made up of the crude drug of following weight portion:
Radix et Rhizoma Dysosmatis 8-12 part, notopodium root 8-12 part, Herba Cheilanthes chusane 22-26 part, Radix Musae 8-12 part, Bombyx Batryticatus 8-12 part, Radix Serissae 28-32 part, Alumen 5-7 part, Herba Inulae cappae 8-12 part, Radix Angelicae Dahuricae 28-32 part, Herba Schizonepetae 5-7 part, Caulis Spatholobi 13-17 part.
3. the Chinese medicine for the treatment of trimester of pregnancy vulval eczema according to claim 2, is characterized in that, is made up of the crude drug of following weight portion:
10 parts of Radix et Rhizoma Dysosmatiss, 10 parts of notopodium roots, 24 parts of Herba Cheilanthes chusanes, 10 parts of Radix Musae, 10 parts of Bombyx Batryticatus, 30 parts of Radix Serissae, 6 parts of Alumens, 10 parts of Herba Inulae cappaes, 30 parts of the Radixs Angelicae Dahuricae, 6 parts of Herba Schizonepetae, 15 parts of Caulis Spatholobis.
4. according to the Chinese medicine of the treatment trimester of pregnancy vulval eczema described in claim 1 or 2 or 3, it is characterized in that, the dosage form of described Chinese medicine is external preparation.
5. the Chinese medicine for the treatment of trimester of pregnancy vulval eczema according to claim 4, is characterized in that, the dosage form of described Chinese medicine is external-use lotion.
6. the preparation method of the Chinese medicine of the treatment trimester of pregnancy vulval eczema described in claim 1 or 2 or 3, comprises the steps:
(1) take various raw materials according to required weight portion;
(2) Herba Cheilanthes chusane, Radix Serissae, Herba Inulae cappae, the Radix Angelicae Dahuricae, Herba Schizonepetae are ground into coarse powder, vapor distillation extracts volatile oil, and for subsequent use after collecting, and the medicinal residues after extraction are for subsequent use after mixing;
(3) by the medicinal residues after Radix et Rhizoma Dysosmatis, notopodium root, Radix Musae, Bombyx Batryticatus, Caulis Spatholobi and above-mentioned distillating extracting oil, decoct with water extraction secondary, adding for the first time injection volume 4-6 times of water gaging decocts 2 hours, adding for the second time injection volume 3-5 times of water gaging decocts 1.0 hours, collecting decoction, add again the aqueous solution after above-mentioned distillation, filter; It is 1.09～1.13 concentrated solution that 60 DEG C of filtrates are concentrated into relative density, lets cool, and adds ethanol to reaching 65-75% containing alcohol amount, stirs evenly, and 0～5 DEG C of standing cold preservation 24 hours, filters; It is 1.07～1.12 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, adds the water dilution of equivalent, stir evenly, then 2～5 DEG C of standing cold preservation 24 hours, filter;
(4) filtrate adds above-mentioned Alumen fine powder, with adding with stirring; And regulate pH value to 4.5～6.0, and add water and be adjusted to 1000 weight portions, filter, sterilizing, to obtain final product.
7. the preparation method of the Chinese medicine for the treatment of trimester of pregnancy vulval eczema according to claim 6, is characterized in that, adds for the first time 5 times of water gagings of injection volume and decoct 2 hours in described step (3), adds for the second time 4 times of water gagings of injection volume and decocts 1.0 hours.
8. the preparation method of the Chinese medicine for the treatment of trimester of pregnancy vulval eczema according to claim 6, is characterized in that, adds ethanol to reaching 70% containing alcohol amount in described step (3).
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| CN107412617A (en) * | 2017-08-07 | 2017-12-01 | 于瑞霞 | A kind of Chinese medicine composition for treating pregnant eczema of vulva and preparation method thereof |
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| Title |
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| 葛湄菲，朱庆文主编: "《常见病中药熏洗实效方》", 30 September 2008, 化学工业出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107412617A (en) * | 2017-08-07 | 2017-12-01 | 于瑞霞 | A kind of Chinese medicine composition for treating pregnant eczema of vulva and preparation method thereof |
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Application publication date: 20140813 |