CN103656323A - Traditional Chinese medicine for treating erythroderma-type psoriasis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating erythroderma-type psoriasis, which is characterized by being prepared from the following medicinal materials in the same parts by weight: carapax eretmochelyos, crude gardenia jasminoides, coptis chinensis, honeysuckle, fructus forsythiae, dandelion, dried rehmannia root, lalang grass rhizome, moutan bark, dendrobium nobile, radix polygonati officinalis and radix ophiopogonis. According to the invention, through scientific medicinal material screening and reasonable proportion, the prepared liquid has effects of clearing away heat, detoxifying, cooling blood, nourishing yin, relieving itching and the like and can effectively treat erythroderma-type psoriasis. For the past eight years, application to 30 patients shows that the effective rate of the traditional Chinese medicine reaches 96.7 percent and erythroderma-type psoriasis does not relapse after the patients are cured.

Description

A kind of psoriasic Chinese medicine of erythroderma type for the treatment of

Technical field

The present invention relates to a kind of Chinese medicine, particularly a kind of psoriasic Chinese medicine of erythroderma type that is used for the treatment of.

Background technology

It is many because malpractice or other reasons make original homeliness type psoriasis or pustular psoriasis change erythroderma into that erythrodermic psoriasis (Erythrodermicpsiasis) has another name called psoriasis erythroderma (Erythrodemapsiaticum) primary disease.Common reason is to carry out in psoriasis the medicine for external use that phase application of stimulus is violent, or stops using suddenly and occur sharply to spread and become primary disease because of some immunosuppressive drug for oral administration.Common as corticosteroid hormone for oral administration, subtract in medicine process and occur.In addition in pustule process of extinction, also can there is erythroderma in pustular psoriasis.Primary disease accounts for psoriasic 1%.Erythrodermic psoriasis is psoriasic a kind of special inflammation type, often involves body surface and reaches more than 75%.Erythrodermic psoriasis is a kind of specific type psoriasis of involving whole body most skin, but sickness rate is minimum in psoriasis.In psoriasic Four types, the influence of this disease is the most serious a kind of compared with other.Current Therapeutic Method has many kinds, as interior, use 17-hydroxy-11-dehydrocorticosterone, whole body supporting treatment, medicine for external use is processed as Calamine Lotion or non-irritating antipruritic cream, emulsifiable paste, Chinese traditional treatment etc., western medicine is respite, can not effect a radical cure, and also there is no at present a kind of psoriasic Chinese medicine for the treatment of erythroderma type that is exclusively used in.

Summary of the invention

The object of this invention is to provide a kind of psoriasic Chinese medicine of erythroderma type for the treatment of, by selecting suitable medical material and proportioning thereof to reach, treat safely and effectively the psoriasic object of erythroderma type.

For realizing the technical scheme that above-mentioned purpose of the present invention adopts, be: a kind of psoriasic Chinese medicine of erythroderma type for the treatment of, is characterized in that being made by the medical material of following weight proportion:

Carapax Eretmochelydis, Fructus Gardeniae, Rhizoma Coptidis, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Radix Rehmanniae, Rhizoma Imperatae, Cortex Moutan, Herba Dendrobii, Rhizoma Polygonati Odorati, Radix Ophiopogonis equal portions.

In the present invention's formula, source and the function of related medical material cure mainly as follows:

The first sheet at Carapax Eretmochelydis [source] Testudinidae animal Carapax Eretmochelydis Eretmochelys imbricata L. back.[nature and flavor] are sweet, cold.[function cures mainly] heat-clearing and toxic substances removing, relieving palpitation suppressing the hyperactive liver.For calentura, go mad, delirium, infantile convulsion, carbuncle sore tumefacting virus.

Fructus Gardeniae [source] this product is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis.[nature and flavor] hardship, cold.[return through] GUIXIN, lung, tri-jiao channel.

[function cures mainly] fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.

Rhizoma Coptidis [source] this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C. Y. Cheng et Hsiao or Coptis Teeta Wall Coptis teeta Wall..[nature and flavor] hardship, cold.[return through] GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.

Flos Lonicerae [source] this product is the dry flower of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb., Flos Lonicerae Lonicera hypoglauca Miq., Flos Lonicerae (hair calyx Radix Ophiopogonis) Lonicera confusa DC. or hair style Radix Ophiopogonis Lonicera dasystyla Rehd. or the flower that band is just opened.[nature and flavor] are sweet, cold.[return through] returns lung, the heart, stomach warp.[function cures mainly] heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.

Fructus Forsythiae [source] this product is the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.[nature and flavor] hardship, is slightly cold.[return through] returns lung, the heart, small intestine meridian.

[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, pyretic stranguria urine retention.

Herba Taraxaci [source] this product is feverfew Herba Taraxaci Taraxacum mongolicum Hand.-Mazz., alkali ground Herba Taraxaci Taraxacum sinicum Kitag. or the dry herb that belongs to several plants together.[nature and flavor] are bitter, sweet, cold.[return through] returns liver, stomach warp.[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Radix Rehmanniae [source] this product is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Radix Rehmanniae is slowly cured to approximately most probably dry.Be " Radix Rehmanniae ".[nature and flavor] Radix Rehmanniae: sweet, cold.[return through] GUIXIN, liver, kidney channel.

[function cures mainly] clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, sends out speckle dermexanthesis.

Rhizoma Imperatae [source] this product is the dry rhizome of grass Herba Imperatae Imperata cylindrica Beauv. var. major (Nees) C. E. Hubb..[nature and flavor] are sweet, cold.[return through] returns lung, stomach, urinary bladder channel.[function cures mainly] cooling blood for hemostasis, clearing away heat and promoting diuresis.For heat in blood, spit blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.

Cortex Moutan [source] this product is the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..[nature and flavor] are bitter, pungent, are slightly cold.[return through] GUIXIN, liver, kidney channel.[function cures mainly] clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.

Fresh or the dry stem of the cultivation product of Herba Dendrobii [source] orchid Dendrobium nobile Dendrobium nobile Lindl, orchid Dendrobium chrysotoxum Dendrobium chrysotoxum Lindl, orchid Dendrobium fimbriatum Hook. Dendrobium fimbriatum Hook.var.oculatum Hook and congener allied species thereof.[nature and flavor] sweet in the mouth, cold nature.[return through] enters stomach, kidney channel.Nourishing YIN and clearing away heat, lung moistening nourishing the stomach, strengthening the tendons and bones.[function cures mainly] nourishing Tianjin, health invigorating, strengthen the spleen and stomach, hepatoprotective function of gallbladder promoting, suppress tumor, nourish skin.Cure mainly the diseases such as consumption of body fluid caused by febrile disease, xerostomia excessive thirst, stomachache retch, the few expectorant of cough.

Rhizoma Polygonati Odorati [source] this product is the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati Polygonatum odoratum (Mill.) Druce.[nature and flavor] are sweet, are slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.

Radix Ophiopogonis, [source] this product was the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..[nature and flavor] are sweet, and micro-hardship, is slightly cold.[return through] GUIXIN, lung, stomach warp.[function cures mainly] YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.

During the outbreak of erythrodermic psoriasis, clinical manifestation is: at original psoriasis skin lesion position, occur diffusivity flushing, dark red or purplish red in early days, swelling, infiltration, outward appearance is adhered to a large amount of squamas, and inexhaustible coming off, then expand gradually, and have Mild edema or infiltration, skin is mostly dry, minority can be moistening incrustation, accompanies serious pruritus simultaneously.Now, the psoriasic feature such as silvery white squama and petechial hemorrhage often disappears.Heat, fear of cold, headache, general malaise etc. often occur together.Before outbreak or while showing effect, there is fever more, can, up to 40 degree, be directly proportional to the order of severity of skin lesion.In addition can be with lymphadenectasis, arthralgia, myalgia, the visible Staphylococcus aureus bacteremia of severe patient, multiple bone marrow inflammation, endocarditis, pneumonia, with in peripheral blood from cytosis, albumin level reduce, dielectric disorder, occasionally have liver, renal dysfunction.Due to the defensive skin damage of large area, the moisture running off by epidermis increases, and causes dehydration. and Chinese medicine thinks that erythroderma type psoriasis has blood deficiency scorching in being, is subject to ailment said due to cold or exposure outward, due to the profit of skin flatus blood.Aspect endogenous cause of ill, focus on the transformation of blood system, wherein dry, the blood deficiency of heat in blood, blood, blood stasis are the common pathogenic factor of erythroderma type psoriasis; Aspect exopathogenic factor, take ailment said due to cold or exposure as main, and hold concurrently and cause a disease mutually with cold, wet, dry, malicious etc.The medical material screening of the present invention by science and reasonably proportioning, prepared medicinal liquid has heat clearing away, removing toxic substances, removing heat from blood, YIN nourishing, the effect such as antipruritic, can effectively treat erythroderma type psoriasis, over 8 years, by 30 routine patients' use is shown, effective percentage reaches 96.7%, more after no longer recurrence.

Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:

1, physical data

Inventor has collected 50 routine out-patients in January, 2006-2013 altogether between year April, wherein, and male 33 examples, female's 27 examples, age 28-54 year, the state of an illness 2 days-8 days.Be divided at random: treatment group 30 examples, matched group 20 examples.The data there was no significant differences such as two groups of ages, have comparability.

2, test method

2.1 matched groups are treated with 17-hydroxy-11-dehydrocorticosterone, medicinal external emulsifiable paste by interior, take to specifications.50 days courses for the treatment of.

The capsule that the oral the present invention of 2.2 treatment group makes according to specific embodiment 1, early, middle and late each once.50 days courses for the treatment of.

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterions of therapeutical effect:

Recovery from illness: the psoriasic clinical symptoms of erythroderma type all disappears.Take a turn for the better: the psoriasic clinical symptom relief of erythroderma type, the state of an illness is controlled.Invalid: clinical symptoms is without being clearly better or increasing the weight of.

3.2 treatment statistical results are in Table 1.

Table 1 liang group curative effect comparison

Group	n	Recovery from illness	Cure rate	Take a turn for the better	Invalid	Total effective rate (%)
							Treatment group	30	20	66.7%	9	1	96.7%
Matched group	20	5	25%	10	5	75%

As can be seen here, adopt the medicine that prescription of the present invention makes can safe and effective treatment erythroderma type psoriasis.

The specific embodiment

For Comprehension and Implementation the present invention better, below in conjunction with specific embodiment, further illustrate the present invention.

Specific embodiment 1

Take 10 grams of Carapax Eretmochelydiss, 10 grams of Fructus Gardeniae, 10 grams of Rhizoma Coptidis, 10 grams of Flos Loniceraes, 10 grams of Fructus Forsythiaes, 10 grams of Herba Taraxacis, 10 grams of Radix Rehmanniae, 10 grams of Rhizoma Imperataes, 10 grams of Cortex Moutans, 10 grams of Herba Dendrobiis, 10 grams of Rhizoma Polygonati Odorati, 10 grams of Radix Ophiopogonis, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, incapsulate shell, must meet the capsule of 1 day consumption of normal adult.

Be used for the treatment of erythroderma type psoriasis.Oral, every bu is taken for early, middle and late three times.

Specific embodiment 2

Take 10 grams of Carapax Eretmochelydiss, 10 grams of Fructus Gardeniae, 10 grams of Rhizoma Coptidis, 10 grams of Flos Loniceraes, 10 grams of Fructus Forsythiaes, 10 grams of Herba Taraxacis, 10 grams of Radix Rehmanniae, 10 grams of Rhizoma Imperataes, 10 grams of Cortex Moutans, 10 grams of Herba Dendrobiis, 10 grams of Rhizoma Polygonati Odorati, 10 grams of Radix Ophiopogonis, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, pack, must meet the powder of 1 day consumption of normal adult.

Be used for the treatment of erythroderma type psoriasis.Oral, every bu is taken for early, middle and late three times.

Specific embodiment 3

Take 10 grams of Carapax Eretmochelydiss, 10 grams of Fructus Gardeniae, 10 grams of Rhizoma Coptidis, 10 grams of Flos Loniceraes, 10 grams of Fructus Forsythiaes, 10 grams of Herba Taraxacis, 10 grams of Radix Rehmanniae, 10 grams of Rhizoma Imperataes, 10 grams of Cortex Moutans, 10 grams of Herba Dendrobiis, 10 grams of Rhizoma Polygonati Odorati, 10 grams of Radix Ophiopogonis, add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, according to this area common process, granulate, pack, must meet the granule of 1 day consumption of normal adult.

Be used for the treatment of erythroderma type psoriasis.Oral, every bu is taken for early, middle and late three times.

  

Claims (1)

1. a treatment erythroderma type psoriasic Chinese medicine, is characterized in that being made by the medical material of following weight proportion: Carapax Eretmochelydis, Fructus Gardeniae, Rhizoma Coptidis, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Radix Rehmanniae, Rhizoma Imperatae, Cortex Moutan, Herba Dendrobii, Rhizoma Polygonati Odorati, Radix Ophiopogonis equal portions.