CN104208532B - A kind of medicine for treating erythrodermic psoriasis - Google Patents
A kind of medicine for treating erythrodermic psoriasis Download PDFInfo
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- CN104208532B CN104208532B CN201410471579.XA CN201410471579A CN104208532B CN 104208532 B CN104208532 B CN 104208532B CN 201410471579 A CN201410471579 A CN 201410471579A CN 104208532 B CN104208532 B CN 104208532B
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Abstract
The invention discloses a kind of medicine for treating erythrodermic psoriasis, by the 25g of cornu bubali 15, the 35g of the dried rhizome of rehmannia 25, the 14g of the radix paeoniae rubrathe 10, the 14g of the root bark of tree peony 10, the 20g of the red sage root 10, the 20g of radix scrophulariae 10, the 14g of golden cypress 10, the 35g of smilax 25, peach kernel 8 12, the 20g of Radix Angelicae Sinensis 10, after well mixed, extract the active component of Chinese medicine, add water to cook 3 times, 0.5~1 hour every time, merge 3 decocting liquids, filtering, it is condensed into the thick paste that 60 DEG C of relative densities are 1.25~1.3, after 50~60 DEG C are dried, it is crushed to the medicinal powder of 100 mesh, it is fitted into capsule, capsule product is made in sterilization.1.5 grams of every weight of this product.Medicine of the present invention is clearing heat and detoxicating, cool blood benefit blood, promoting blood circulation and removing blood stasis, clear spot moves back rash, and treatment erythrodermic psoriasis curative effect is fast, short treating period, have no side effect, through 120 patients course for the treatment of of drug therapy 5 of the present invention by oral administration, cure 96, take a turn for the better 12, invalid 12, effective percentage 90%, cure rate 80%.During medication, have no adverse reaction.
Description
Technical field
It is a kind of medicine for treating erythrodermic psoriasis specifically the present invention relates to a kind of medicine for treating psoriasis
Thing.
Background technology
Erythrodermic psoriasis is a kind of special types of psoriasis for involving whole body most skin, but the incidence of disease is in silver bits
It is minimum in disease.Erythrodermic psoriasis is often secondary to some unmanageable psoriasis in plaques.There is the cycle in patient
Property rubefaction in extensive range, and sick illing skin is often accompanied by serious furfur and disturbs pain of itching.It is well known that red skin
Sick psoriasis pustulosa is very intractable disease, and patient's medicine injection spends a lot of money all to cure completely, makes patient feel bad very much
Pain.There is the medicine of many treatment erythrodermic psoriasis at present, but curative effect is undesirable, price is also high, is caused to patient
Financial burden.
The content of the invention
The present invention solves the deficiencies in the prior art, and there is provided a kind of short treating period, treatment erythrodermic silver evident in efficacy
Consider the medicine of disease to be worth doing.
The medicine of the present invention is prepared by the bulk drug of following ratio of weight and number：
Cornu bubali 15-25 dried rhizome of rehmannia 25-35 radix paeoniae rubrathe 10-14 root barks of tree peony 10-14
Red sage root 10-20g radix scrophulariae 10-20 golden cypress 10-14 smilaxs 25-35
Peach kernel 8-12 safflower 8-12 Radix Angelicae Sinensis 10-20.
The preferred weight fraction of the bulk drug is：
Cornu bubali 20g dried rhizome of rehmannia 30g radix paeoniae rubrathe 12g root barks of tree peony 12g
Red sage root 15g radix scrophulariae 15g golden cypress 12g smilaxs 30g
Peach kernel 10g safflower 10g Radix Angelicae Sinensis 15g.
After above-mentioned various Chinese medicines are well mixed according to described ratio of weight and number, add water to cook 3 times, 0.5~1 is small every time
When, merge 3 decocting liquids, filtering is condensed into the thick paste that 60 DEG C of relative densities are 1.25~1.3, after 50~60 DEG C are dried, crushed
To the medicinal powder of 100 mesh, it is fitted into capsule, capsule product is made in sterilization.
According to tcm treatment according to syndrome differentiation, erythroderma can be divided into it is scorchingly hot pent up, heat toxin holds wet and excess heat impairment of yin card, of the present invention group under the arm
The clearing heat and detoxicating blood cooling and ecchymoses removing of cornu bubali, smilax is monarch in side；The dried rhizome of rehmannia, the radix paeoniae rubrathe, the root bark of tree peony, the blood-nourishing of Radix Angelicae Sinensis cool blood are minister；Golden cypress, member
It is assistant to join replenishing the vital essence and removing heat；The red sage root, peach kernel, safflower promoting blood circulation and removing blood stasis are to make.Each medicine share gather altogether it is clearing heat and detoxicating, cool blood benefit blood, promoting blood circulation
Stagnation resolvation, clear spot moves back the work(of rash.Prescription of the present invention be the mechanism for Chinese traditional treatment erythrodermic psoriasis come compatibility, to treatment
Erythrodermic psoriasis has significant curative effect.
Further to investigate the clinical efficacy of drug therapy erythrodermic psoriasis of the present invention, 120 erythrodermics are selected
Psoriatic has carried out clinical observation on the therapeutic effect.
Clinical data：
Outpatient 120 is selected, wherein male 80, female 40, course of disease May~3 year, 15~75 years old age.
Diagnostic criteria
Diagnosis can be made according to morbidity history, clinical symptoms, medication treatment history and laboratory examination：
（1）It can be sent out in any age, but be many using person in middle and old age, male is more than women, accounts for 1% of psoriatic or so.
Flush and substantial amounts of furfur occur for the whole body of patient or most skins, and the typical skin damaged of original homeliness type all disappears, or
Person is only capable of on the small pieces normal skin that is carried at some, it is seen that a small number of typical skin damageds；
（2）Hand and pin may occur in which the decortication of bulk.Just as the gloves being torn are as socks.Refer to（Toe）It is mixed that first becomes
It is turbid, thicken, or even be badly deformed and come off.Whole body itch substantially, and is often accompanied by having a fever, have a headache and the symptom such as general malaise；
（3）It is before acute onset person's dermexanthesis to have heating more, shiver with cold, the early stage reaction such as burnout.Fash is initial often to bend body in four limbs
Side or joint bend face and occur a small amount of erythema, and whole body is spread to rapidly, in extensive flush, then a large amount of furfurs.Head And Face is because of skin
Fat is more or infection causes the scales of skin that peel off thicker, can be connected together with hair, can typically cause trichomadesis；
（4）Pachyonychia, uneven, sallow comes off eventually.Pharynx, schneiderian membrane can also be involved.It is often accompanied by enlargement of lymph nodes.Chemical examination
Room is checked：It can find that acidophic cell is raised in leukocytosis, blood, blood ammonia is higher 3 to 7 times than normal, and total serum protein amount subtracts
Small, albumin reduction and gamma globulin increase, and dysfunction of liver occurs in patient with severe symptoms.
Treatment method
Oral medicine of the present invention, one time 5, twice a day, once in the morning and once at night.
Criterion of therapeutical effect
Clinical recovery：Erythema skin damaged all disappears or regression area>90%；
It is effective：Erythema skin damaged regression area 61%~90%；
It is progressive：Erythema skin damaged regression area 21%~60%；
It is invalid：Erythema skin damaged regression area≤20%.
Treatment results
120 patients course for the treatment of of drug therapy 5 of the present invention by oral administration, cures 96, takes a turn for the better 12, invalid 12, efficient
90%, cure rate 80%.During medication, have no adverse reaction.
Model case
Case one：Korea Spro so-and-so, male, 45 years old.The scaling fash recurrent exerbation of main cause whole body 1 year half, aggravates January in 2010
On April 23, in goes to a doctor.There is the squamous papule being dispersed in without obvious inducement bilateral ancon in patient before 1 year half, and clear border is struck off
Scales of skin that peel off red color visible film and petechial hemorrhage, partly can voluntarily disappear.But recurrent exerbation, the weight summer in winter is light, and skin damaged gradually increases, and expands
Greatly.There is similar skin damaged, no rotten to the corn, sepage in succession in scalp and four limbs.Once many places treat-and-release, there is certain curative effect.Patient before January
There is new skin damaged and gone to a doctor again in double lower limb and the both hands back of the body.Patient mental's appetite is good, and stool and urine and sleep are normal.Have a medical check-up：Body temperature
36.4 DEG C, face dolorosa.The no positive sign of cardiopulmonary abdomen.Training is checked：Scalp and the visible squamous papule being dispersed in of four limbs, especially with
Double lower limb is many, clear border, symmetrical, and there is the silvery white scales of skin that peel off on substrate flush, surface, strike off scales of skin that peel off red color visible film and
Petechial hemorrhage.Feel that itch is obvious.It is diagnosed as erythrodermic psoriasis.Erythrodermic psoriasis medicine is given, skin after May is treated
Rash all disappears, clinical recovery.
Case two：Lv, male, 30 years old.The scaling fash recurrent exerbation of main cause whole body 15 years, aggravates July in 2011
Year August 15 is gone to a doctor., because of the big cause insomnia of pressure, there is the squamous papule that double lower limb is dispersed in therewith before 15 years in patient, with
Itch, gradually increases, expands, be partially integrated into the film later, and similar skin damaged occur in succession in trunk and four limbs, no rotten to the corn, sepage, once
Repeatedly to ground diagnosis and treatment such as Taiyuan, Yunchengs, oral methoxy dish purine has certain curative effect, but recurrent exerbation, and the weight summer in winter is light.Skin damaged before July
Aggravate, double forearm and bilateral shank skin damaged fusions are in blocks, substrate flush, inflammatory infiltration substantially, significantly go to a doctor by itch.Patient mental
Still, stool and urine and sleep are normal for appetite.Have a medical check-up：36.7 DEG C of body temperature, face dolorosa.The no positive sign of cardiopulmonary abdomen.Skin training
Check：Squamous papule that trunk and four limbs are dispersed in, patch, clear border are symmetrical, substrate flush, inflammatory infiltration substantially,
There is a small amount of silvery white scales of skin that peel off on surface, strikes off the scales of skin that peel off without obvious red pigment and petechial hemorrhage；The fusion of bilateral shank skin damaged is in blocks, from
Feel that itch is notable.It is diagnosed as psoriasis.The medicine of erythrodermic psoriasis is given, fash after June is treated and all disappears, clinic is fullyed recover from an illness
More.
Case three：Shen so-and-so, man, 30 years old.The general hair sheet scales of skin that peel off spot of main cause whole body 5 years, aggravates July in September in 2013 1 day
It is medical.Patient caught a cold before 15 years finds that papule, the scales of skin that peel off spot of kermesinus sorghum size occurs in the whole body after transfusion, feels slight hair
Itch, do not draw attention, skin damaged progressive is aggravated after a few days, once took traditional Chinese medicine and Western medicine methotrexate Tripterygium wilfordii Polyglycosidium Tablets etc. are controlled
Treat, recurrent exerbation, skin damaged is gradually extended to coin shape.The weight summer in winter is light.After cause cat fever in July above-mentioned symptom aggravate go to a doctor in
Our hospital.Have a medical check-up：37.4 DEG C of body temperature, normal face.The no positive sign of cardiopulmonary abdomen.Skin training is checked：Skin damaged is big in palm.Under double
There is a little normal skin island between limb skin damaged map shape, double flush below knee, with infiltration, surface is smooth shinny and with bran sample
The canescence scales of skin that peel off comes off.Both legs swelling." erythrodermic psoriasis " is diagnosed as, ox erythrodermic psoriasis medicine is taken, after July
Skin rash whole regression clinical recovery.
Case four：Sun, women, 26 years old.The scaling fash recurrent exerbation of main cause whole body 3 years, aggravated 2 months in 2012
November 12 went to a doctor.There is the squamous papule that double lower limb is dispersed in patient after being suffered from cold before 3 years, with itch, gradually increase later,
Expand, be partially integrated into the film, similar skin damaged occur in succession in trunk and four limbs, and Taiyuan, Yuncheng etc. are once repeatedly arrived in no rotten to the corn, sepage
Ground diagnosis and treatment, oral methoxy dish purine has certain curative effect, but recurrent exerbation, and the weight summer in winter is light.Skin damaged is aggravated before 2 months, double forearms and bilateral
The fusion of shank skin damaged is in blocks, substrate flush, and inflammatory infiltration substantially, significantly go to a doctor by itch.Patient mental's appetite still, stool and urine and
Sleep is normal.Have a medical check-up：36.7 DEG C of body temperature, face dolorosa.The no positive sign of cardiopulmonary abdomen.Training is checked：What trunk and four limbs were dispersed in
Squamous papule, patch, clear border are symmetrical, substrate flush, and substantially, there is a small amount of silvery white scales of skin that peel off on surface to inflammatory infiltration,
The scales of skin that peel off is struck off without obvious red pigment and petechial hemorrhage；Double forearm and bilateral shank skin damaged fusions are in blocks, feel that itch is notable.Examine
Break as erythrodermic psoriasis.Erythrodermic psoriasis medicine is given, fash after April is treated and all disappears, clinical recovery.
Case five：Yan so-and-so, female, 27 years old, workman.The ictal whole body papule of main cause, scales of skin that peel off spot 5 years, aggravate January in 2012
On June 10, in goes to a doctor.Patient had found that papule, the scales of skin that peel off spot of kermesinus sorghum size occurred in the whole body before 5 years because mood is not freely rear, from
Feel is slightly itched, and is not drawn attention, and skin damaged progressive is aggravated after a few days, is taken a turn for the better after our hospital's outpatient service oral traditional Chinese medicine treatment, afterwards
Recurred after mood is not smooth.Above-mentioned symptom aggravates to go to a doctor in our hospital again before January.Have a medical check-up：37.4 DEG C of body temperature, normal face.Cardiopulmonary
The no positive sign of abdomen.Skin training is checked：The papule of whole body skin kermesinus sorghum or bigger, scales of skin that peel off spot, substrate peony.Grab
Visible silvery white micaceous scales come off, whole body dry skin, coarse, four limbs are more so, it is seen that the filbert fish scale-shaped scales of skin that peel off.Examine
Break as erythrodermic psoriasis.Erythrodermic psoriasis medicine is given, skin rash after April is treated and all disappears, clinical recovery.
Case six：In so-and-so, female, 12 years old.The scaling fash recurrent exerbation of main cause whole body 2 years, aggravates 15 days in 2012 1
The moon 17 goes to a doctor.There is the squamous papule that double lower limb is dispersed in before 2 years without obvious inducement in patient, with itch, gradually increased later
Many, expansion, is partially integrated into the film, and similar skin damaged occur in succession in trunk and four limbs, and Taiyuan, Yuncheng are once repeatedly arrived in no rotten to the corn, sepage
Etc. ground diagnosis and treatment, oral methoxy dish purine has certain curative effect, but a recurrent exerbation, and the weight summer in winter is light.Skin damaged is aggravated before 15 days, double forearms and double
Side shank skin damaged fusion is in blocks, substrate flush, and inflammatory infiltration substantially, significantly go to a doctor by itch.Patient mental's appetite is fine, stool and urine
And sleep is normal.Have a medical check-up：36.7 DEG C of body temperature, the no positive sign of cardiopulmonary abdomen.Training is checked：The scaling mound that trunk and four limbs are dispersed in
Rash, patch, clear border are symmetrical, substrate flush, and substantially, there is a small amount of silvery white scales of skin that peel off on surface to inflammatory infiltration, strikes off the scales of skin that peel off
Without obvious red pigment and petechial hemorrhage；Double forearm and bilateral shank skin damaged fusions are in blocks, feel that itch is notable.It is diagnosed as red skin
Sick psoriasis pustulosa.Erythrodermic psoriasis medicine is given, fash all disappears after treating 2 months, clinical recovery.
Embodiment
Embodiment 1
Removing impurity is weighed, the cornu bubali 15g that cleans up, dried rhizome of rehmannia 25g, radix paeoniae rubrathe 10g, root bark of tree peony 10g, red sage root 10g, radix scrophulariae
After 10g, golden cypress 10g, smilax 25g, peach kernel 8g, safflower 8g, Radix Angelicae Sinensis 10g are well mixed, the active component of Chinese medicine is extracted, is added water
Decoct 3 times, 0.5~1 hour every time, merge 3 decocting liquids, filtering is condensed into the thick paste that 60 DEG C of relative densities are 1.25~1.3,
After 50~60 DEG C are dried, the medicinal powder of 100 mesh is crushed to, is fitted into capsule, capsule product is made in sterilization.This product every
Weigh 1.5 grams.
Application method：Oral medicine of the present invention, one time 5, twice a day, once in the morning and once at night.
Embodiment 2
Removing impurity is weighed, the cornu bubali 20g that cleans up, dried rhizome of rehmannia 30g, radix paeoniae rubrathe 12g, root bark of tree peony 12g, red sage root 15g, radix scrophulariae
After 15g, golden cypress 12g, smilax 30g, peach kernel 10g, safflower 10g, Radix Angelicae Sinensis 15g are well mixed, the active component of Chinese medicine is extracted, plus
Decocting boils 3 times, 0.5~1 hour every time, merges 3 decocting liquids, filtering, be condensed into 60 DEG C of relative densities for 1.25~1.3 it is thick
Cream, after 50~60 DEG C are dried, is crushed to the medicinal powder of 100 mesh, is fitted into capsule, capsule product is made in sterilization.This product
Every 1.5 grams of weight.
Application method：Oral medicine of the present invention, one time 5, twice a day, once in the morning and once at night.
Embodiment 3
Removing impurity is weighed, the cornu bubali 25g that cleans up, dried rhizome of rehmannia 35g, radix paeoniae rubrathe 14g, root bark of tree peony 14g, red sage root 20g, radix scrophulariae
After 20g, golden cypress 14g, smilax 35g, peach kernel 12g, safflower 12g, Radix Angelicae Sinensis 20g are well mixed, the active component of Chinese medicine is extracted, plus
Decocting boils 3 times, 0.5~1 hour every time, merges 3 decocting liquids, filtering, be condensed into 60 DEG C of relative densities for 1.25~1.3 it is thick
Cream, after 50~60 DEG C are dried, is crushed to the medicinal powder of 100 mesh, is fitted into capsule, capsule product is made in sterilization.This product
Every 1.5 grams of weight.
Application method：Oral medicine of the present invention, one time 5, twice a day, once in the morning and once at night.
Claims (2)
1. a kind of medicine for treating erythrodermic psoriasis, is prepared by the bulk drug of following ratio of weight and number：
Cornu bubali 15-25 dried rhizome of rehmannia 25-35 radix paeoniae rubrathe 10-14 root barks of tree peony 10-14
Red sage root 10-20g radix scrophulariae 10-20 golden cypress 10-14 smilaxs 25-35
Peach kernel 8-12 safflower 8-12 Radix Angelicae Sinensis 10-20.
2. treating the medicine of erythrodermic psoriasis according to claim 1, the parts by weight of wherein bulk drug are：
Cornu bubali 20g dried rhizome of rehmannia 30g radix paeoniae rubrathe 12g root barks of tree peony 12g
Red sage root 15g radix scrophulariae 15g golden cypress 12g smilaxs 30g
Peach kernel 10g safflower 10g Radix Angelicae Sinensis 15g.
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| CN201410471579.XA CN104208532B (en) | 2014-09-17 | 2014-09-17 | A kind of medicine for treating erythrodermic psoriasis |
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| CN104208532B true CN104208532B (en) | 2017-11-07 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105343707A (en) * | 2015-11-23 | 2016-02-24 | 济南科纳信息科技有限公司 | Traditional Chinese medicine used for treating erythema annulare centrifugum |
| CN106266832A (en) * | 2016-09-12 | 2017-01-04 | 防城港思创信息技术有限公司 | A kind of erythroderma shape psoriasis treatment medicine |
| CN113952413A (en) * | 2021-11-24 | 2022-01-21 | 南宁市中医医院 | Rhubarb and liquorice lotion for treating skin diseases |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653562A (en) * | 2009-09-15 | 2010-02-24 | 周大红 | Traditional Chinese medicine for treating erythrodermic psoriasis |
| CN103405718A (en) * | 2013-08-08 | 2013-11-27 | 李盛民 | TCM pill for treating psoriasis |
| CN103505667A (en) * | 2013-08-10 | 2014-01-15 | 马艳春 | Oral traditional Chinese medicine composition for treating psoriasis |
| CN103656323A (en) * | 2013-12-27 | 2014-03-26 | 孙斌 | Traditional Chinese medicine for treating erythroderma-type psoriasis |
-
2014
- 2014-09-17 CN CN201410471579.XA patent/CN104208532B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653562A (en) * | 2009-09-15 | 2010-02-24 | 周大红 | Traditional Chinese medicine for treating erythrodermic psoriasis |
| CN103405718A (en) * | 2013-08-08 | 2013-11-27 | 李盛民 | TCM pill for treating psoriasis |
| CN103505667A (en) * | 2013-08-10 | 2014-01-15 | 马艳春 | Oral traditional Chinese medicine composition for treating psoriasis |
| CN103656323A (en) * | 2013-12-27 | 2014-03-26 | 孙斌 | Traditional Chinese medicine for treating erythroderma-type psoriasis |
Non-Patent Citations (1)
| Title |
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| 红皮病性银屑病致病因素及治疗方法探讨;张倩等;《中国中西医结合皮肤性病学杂志》;20031230(第04期);232-233 * |
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