CN104436121B - It is a kind of to treat irregular menstruation, small distention and fullness in the abdomen, the medicine to fail to be impregnated for a long time - Google Patents

It is a kind of to treat irregular menstruation, small distention and fullness in the abdomen, the medicine to fail to be impregnated for a long time Download PDF

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CN104436121B
CN104436121B CN201410676861.1A CN201410676861A CN104436121B CN 104436121 B CN104436121 B CN 104436121B CN 201410676861 A CN201410676861 A CN 201410676861A CN 104436121 B CN104436121 B CN 104436121B
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radix
medicine
fullness
abdomen
impregnated
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CN104436121A (en
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夏静
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BEIJING INSTITUTE OF TRADITIONAL CHINESE MEDICINE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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Abstract

Irregular menstruation, small distention and fullness in the abdomen, the medicine to fail to be impregnated for a long time are treated the invention discloses a kind of, it is using Radix Angelicae Sinensis, the radix paeoniae rubrathe, cultivated land, Radix Codonopsis, sweet potato, the bighead atractylodes rhizome, Poria cocos, radix glycyrrhizae, rhizoma cyperi, Ligusticum wallichii, Chinese cassia tree, the red sage root, folium artemisiae argyi, safflower, fructus amomi, rhizoma zingiberis, jujube as raw material, through decocting, processing obtained medicament.The present invention drug matching from kidney tonifying, help spleen, soothing the liver, recuperating qi-blood is set about, and the qi and blood inside patient, passages through which vital energy circulates, actual situation, fever and chills etc. are nursed one's health, and improves the physical function of patient, increases its own immunocompetence, effected a radical cure the illness of patient.Through clinical observation for many years, total effective rate has good effect up to 98%, it is quick, pregnancy rate is high, without secondary infertility phenomenon occur, the advantages that having no side effect.

Description

It is a kind of to treat irregular menstruation, small distention and fullness in the abdomen, the medicine to fail to be impregnated for a long time
Technical field
The invention belongs to Gynecology, more particularly to a kind of Chinese traditional treatment irregular menstruation, small distention and fullness in the abdomen, fail to be impregnated for a long time Medicine.
Background technology
With society and economic fast development, environmental quality drastically deteriorates, and work and society bring increasingly to women Big stress, life, diet are irregular in addition, and it is in sub-health state to make increasing women, and wherein inferior health is brought Gynecological disease turn into and influence female life quality, or even concern family and deposit and be, and perplex the most menstruation nothing more than of women not Adjust, fail to be impregnated for a long time, and it is more with malaise symptoms such as small distention and fullness in the abdomen, dysmenorrhoea, restless heat on the palms.On the illness, have it is numerous in/west Medical service law is released, but many drawbacks be present, and more in Western medicine therapy to use hormone, the endocrine to women produces considerable influence, And easily recurrence, cure the symptoms, not the disease；Tcm therapy generally requires a very long conditioning process, Small side effects, by more and more High praise, but curative effect is uneven.
The traditional Chinese medical science thinks, irregular menstruation, small distention and fullness in the abdomen, fail to be impregnated for a long time should from kidney tonifying, help spleen, soothing the liver, recuperating qi-blood is set about.
The content of the invention
The invention discloses a kind of brand-new treatment irregular menstruation, small distention and fullness in the abdomen, the medicine to fail to be impregnated for a long time, Western medicine is avoided Side effect and repeatedly, there is short treating period compared with existing Chinese medicine, quick, cost is low, without recurrence.
The medicine of the present invention, it is the medicament made of the raw material of following weight proportioning：Radix Angelicae Sinensis 6 ~ 30, the radix paeoniae rubrathe 10 ~ 25, cultivated land 10 ~ 25, Radix Codonopsis 5 ~ 25, sweet potato 5 ~ 30, the bighead atractylodes rhizome 6 ~ 25, Poria cocos 6 ~ 25, radix glycyrrhizae 5 ~ 30, rhizoma cyperi 5 ~ 25, Ligusticum wallichii 5 ~ 20, Chinese cassia tree 5 ~ 20th, the red sage root 5 ~ 20, folium artemisiae argyi 5 ~ 20, safflower 5 ~ 15, fructus amomi 5 ~ 15, rhizoma zingiberis 3 ~ 25, jujube 10 ~ 50, wherein sweet potato are also referred to as taro.
As a kind of preferred embodiment, the weight proportion of each raw material is：Radix Angelicae Sinensis 10 ~ 25, the radix paeoniae rubrathe 12 ~ 20, cultivated land 10 ~ 22nd, Radix Codonopsis 8 ~ 20, sweet potato 8 ~ 25, the bighead atractylodes rhizome 8 ~ 20, Poria cocos 10 ~ 20, radix glycyrrhizae 8 ~ 25, rhizoma cyperi 8 ~ 22, Ligusticum wallichii 8 ~ 18, Chinese cassia tree 7 ~ 16, The red sage root 8 ~ 16, folium artemisiae argyi 8 ~ 15, safflower 5 ~ 12, fructus amomi 5 ~ 12, rhizoma zingiberis 5 ~ 20, jujube 12 ~ 40.
As a kind of preferred embodiment, the weight proportion of each raw material is：Radix Angelicae Sinensis 12 ~ 20, the radix paeoniae rubrathe 12 ~ 18, cultivated land 10 ~ 18th, Radix Codonopsis 10 ~ 16, sweet potato 10 ~ 20, the bighead atractylodes rhizome 12 ~ 18, Poria cocos 12 ~ 18, radix glycyrrhizae 10 ~ 20, rhizoma cyperi 12 ~ 18, Ligusticum wallichii 10 ~ 15, Chinese cassia tree 10 ~ 15, the red sage root 10 ~ 15, folium artemisiae argyi 9 ~ 12, safflower 8 ~ 10, fructus amomi 8 ~ 10, rhizoma zingiberis 8 ~ 15, jujube 15 ~ 30.
As a kind of preferred embodiment, the weight proportion of each raw material is：Radix Angelicae Sinensis 15, the radix paeoniae rubrathe 15, cultivated land 15, Radix Codonopsis 15, It is sweet potato 15, the bighead atractylodes rhizome 15, Poria cocos 15, radix glycyrrhizae 15, rhizoma cyperi 15, Ligusticum wallichii 12, Chinese cassia tree 12, the red sage root 12, folium artemisiae argyi 10, safflower 9, fructus amomi 9, dry Ginger 10 ~ 15, jujube 20 ~ 30.
Medicinal preparation for oral administration is made in above-mentioned Chinese medicine material according to a conventional method, i.e., described decoction in pharmacy, tablet, pill, Powder, capsule etc., currently preferred formulation are decoction or capsule.
The specific preparation method of medicine decoction and capsule of the present invention is as follows：
Each bulk drug of above-mentioned weight proportion is weighed, is rinsed well with water purification, is added water to cook 2 ~ 4 times, decocts add every time The water that 1.5 ~ 8 times of bulk drug gross weight, 15-30 minutes are decocted, merge each decocting liquid, the filtered dress bag that removes slag, that is, obtain soup Agent；Decocting liquid after filtering is concentrated into relative density 1.15 ~ 1.30（50℃）Thick paste, dry, be ground into fine powder, load glue Capsule is made in capsule；The customary adjuvant of addition pill agent obtains pill；The customary adjuvant of addition film-making agent obtains tablet；Addition Freeze-dried powder obtains injection.
The radix paeoniae rubrathe stimulates the menstrual flow analgesia in the present invention, and Radix Angelicae Sinensis is warm-natured, the thoughts of returning home, liver, spleen three pass through, and has menstruation regulating, enriches blood, the work(of promoting circulation of blood Effect, the radix paeoniae rubrathe on the one hand can be helped preferably to play the sluggish qi and blood that dissipates, unimpeded train of thought, on the other hand coordinated with Ligusticum wallichii, cultivated land As treatment irregular menstruation, small distention and fullness in the abdomen, the basic components to fail to be impregnated for a long time, wherein cultivated land is the medicine of extremely the moon, main kidney tonifying fire Decline, kidney water it is weary, then make it more preferably play tonifying spleen kidney to lose by the bighead atractylodes rhizome, Chinese cassia tree, jujube, assisting a ruler in governing a country for rhizoma zingiberis, but cultivated land can only Enriching yin is unable to clearing damp, and the Poria cocos with dehumidifying effect can help the effect of cultivated land kidney tonifying to play more preferably, and Radix Codonopsis has tonifying Qi, life Tianjin, with the bighead atractylodes rhizome, Poria cocos, the invigorating the spleen of radix glycyrrhizae compatibility, control deficiency of vital energy good effect, with Radix Angelicae Sinensis, the bighead atractylodes rhizome, cultivated land giving young employees remedial-courses in general knowledge and vocational skills qi and blood, tonifying spleen nourishing the stomach pair Spleen, liver, kidney carry out channels and collaterals and qi and blood conditioning, rhizoma cyperi Return liver, tri-jiao channel, have the function that menstruation regulating, analgesia, qi-regulating, Xie Yu, with working as Return, Ligusticum wallichii, fructus amomi, the bighead atractylodes rhizome, radix glycyrrhizae compatibility can be nursed one's health symptoms such as irregular menstruation, small distention and fullness in the abdomen well, folium artemisiae argyi temperature Through hemostasis, menstruation regulating it is antiabortive, the rhizome of nutgrass flatsedge regulation obstruction of the circulation of vital energy, qi-regulating, menstruation regulating is antiabortive, but Chinese cassia tree sheet be promoting circulation of blood aborticide, need to folium artemisiae argyi, Rhizoma cyperi and other selected each taste Chinese medicines are compatible, and actual situation temperature is cold suitable, reach the effect for the treatment of fails to be impregnated for a long time, and safflower promoting blood circulation is logical Through, compel stasis of blood promoting circulation of blood, specially enter blood system, there is kidney tonifying with Radix Angelicae Sinensis, Ligusticum wallichii, Chinese cassia tree, folium artemisiae argyi compatibility, help spleen, soothing the liver, rationale blood effect, Sweet potato is kind to control the deficiency of qi in middle-jiao, weak weak, the sweet pungent complementation of rhizoma zingiberis, jujube, promotes qi and blood circulation, can help sweet potato and other in Medicine preferably plays a role.Each taste Chinese medicine in this Chinese medicine, which cooperates, to be coordinated, and mutually promotes curative effect, and prescription is rigorous, and the division of labor is bright Really drug effect go directly focus, to irregular menstruation, small distention and fullness in the abdomen, fail to be impregnated for a long time and effect a radical cure, and curative effect is fast, pregnancy rate height, no hair Existing secondary infertility phenomenon.
Embodiment
Explanation is further introduced to the present invention in conjunction with embodiment.
Embodiment 1
Take Radix Angelicae Sinensis 6g, radix paeoniae rubrathe 10g, cultivated land 10g, Radix Codonopsis 5g, sweet potato 5g, bighead atractylodes rhizome 6g, Poria cocos 6g, radix glycyrrhizae 5g, rhizoma cyperi 5g, river Rhizome of chuanxiong 5g, Chinese cassia tree 5g, red sage root 5g, folium artemisiae argyi 5g, safflower 5g, fructus amomi 5g, rhizoma zingiberis 3g, jujube 10g, are rinsed well with water, add water to cook 2 It is secondary, the water for adding 8 times of bulk drug gross weight is decocted every time, is decocted 30 minutes, the decocting liquid that merging is 2 times, the filtered dress bag that removes slag, i.e., Obtain decoction.
Embodiment 2
Take Radix Angelicae Sinensis 30g, radix paeoniae rubrathe 25g, cultivated land 25g, Radix Codonopsis 25g, sweet potato 30g, bighead atractylodes rhizome 25g, Poria cocos 25g, radix glycyrrhizae 30g, perfume (or spice) Attached 25g, Ligusticum wallichii 20g, Chinese cassia tree 20g, red sage root 20g, folium artemisiae argyi 20g, safflower 15g, fructus amomi 15g, rhizoma zingiberis 25g, jujube 50g, are rushed with water Wash clean, add water to cook 4 times, decoct the water for adding 3 times of bulk drug gross weight every time, decoct 20 minutes, merge the decocting liquid of 4 times, The filtered dress bag that removes slag, that is, obtain decoction.
Embodiment 3
Take Radix Angelicae Sinensis 10g, radix paeoniae rubrathe 12g, cultivated land 10g, Radix Codonopsis 8g, sweet potato 8g, bighead atractylodes rhizome 8g, Poria cocos 10g, radix glycyrrhizae 8g, rhizoma cyperi 8g, Ligusticum wallichii 8g, Chinese cassia tree 7g, red sage root 8g, folium artemisiae argyi 8g, safflower 5g, fructus amomi 5g, rhizoma zingiberis 5g, jujube 12g, are rinsed well with water, add decocting Boil 3 times, decoct the water for adding 4 times of bulk drug gross weight every time, decoct 22 minutes, merge the decocting liquid of 3 times, the filtered dress that removes slag Bag, that is, obtain decoction.
Embodiment 4
Take Radix Angelicae Sinensis 25g, radix paeoniae rubrathe 20g, cultivated land 22g, Radix Codonopsis 20g, sweet potato 25g, bighead atractylodes rhizome 20g, Poria cocos 20g, radix glycyrrhizae 25g, perfume (or spice) Attached 22g, Ligusticum wallichii 18g, Chinese cassia tree 16g, red sage root 16g, folium artemisiae argyi 15g, safflower 12g, fructus amomi 12g, rhizoma zingiberis 20g, jujube 40g, are rushed with water Wash clean, add water to cook 4 times, decoct the water for adding 1.5 times of bulk drug gross weight every time, decoct 15 minutes, merge 4 times and decoct Liquid, it is filtered remove slag it is concentrated into relative density be 1.30（50℃）Thick paste, dry, be ground into fine powder, be fitted into capsule and make Into capsule.
Embodiment 5
Take Radix Angelicae Sinensis 12g, radix paeoniae rubrathe 12g, cultivated land 10g, Radix Codonopsis 10g, sweet potato 10g, bighead atractylodes rhizome 12g, Poria cocos 12g, radix glycyrrhizae 10g, perfume (or spice) Attached 12g, Ligusticum wallichii 10g, Chinese cassia tree 10g, red sage root 10g, folium artemisiae argyi 9g, safflower 8g, fructus amomi 8g, rhizoma zingiberis 8g, jujube 15g, rinsed with water dry Only, add water to cook 3 times, decoct the water for adding 5 times of bulk drug gross weight every time, decoct 30 minutes, merge the decocting liquid of 3 times, pass through Filter off slag it is concentrated into relative density be 1.25（50℃）Thick paste, dry, be ground into fine powder, add the customary adjuvant of pill agent Obtain pill.
Embodiment 6
Take Radix Angelicae Sinensis 20g, radix paeoniae rubrathe 18g, cultivated land 18g, Radix Codonopsis 16g, sweet potato 20g, bighead atractylodes rhizome 18g, Poria cocos 18g, radix glycyrrhizae 20g, perfume (or spice) Attached 18g, Ligusticum wallichii 15g, Chinese cassia tree 15g, red sage root 15g, folium artemisiae argyi 12g, safflower 10g, fructus amomi 10g, rhizoma zingiberis 15g, jujube 30g, are rushed with water Wash clean, add water to cook 3 times, decoct the water for adding 6 times of bulk drug gross weight every time, decoct 25 minutes, merge the decocting liquid of 3 times, It is filtered remove slag it is concentrated into relative density be 1.20（50℃）Thick paste, dry, be ground into fine powder, add the routine of film-making agent Auxiliary material obtains tablet.
Embodiment 7
Take Radix Angelicae Sinensis 15g, radix paeoniae rubrathe 15g, cultivated land 15g, Radix Codonopsis 15g, sweet potato 15g, bighead atractylodes rhizome 15g, Poria cocos 15g, radix glycyrrhizae 15g, perfume (or spice) Attached 15g, Ligusticum wallichii 12g, Chinese cassia tree 12g, red sage root 12g, folium artemisiae argyi 10g, safflower 9g, fructus amomi 9g, rhizoma zingiberis 10g, jujube 30g, are rinsed with water Totally, add water to cook 4 times, decoct the water for adding 2 times of bulk drug gross weight every time, decoct 18 minutes, merge the decocting liquid of 4 times, warp Filter and remove residue it is concentrated into relative density be 1.15（50℃）Thick paste, dry, be ground into fine powder, addition freeze-dried powder obtains pin Agent.
In order to further investigate drug therapy irregular menstruation of the present invention, small distention and fullness in the abdomen, the clinical efficacy to fail to be impregnated for a long time, selection 200 irregular menstruations, small distention and fullness in the abdomen, the Disease that fails to be impregnated for a long time have carried out clinical observation on the therapeutic effect.
1. case-data
Case totally 200, outpatient service and admissions office patient of the patient for certain academy of traditional Chinese medicine are observed, and has excluded reproductive system Congenital physiological defect and deformity, its single-blind randomized is divided into 2 groups for the treatment of group and control group, every group each 100.In treatment group Age 21-38 year, average age are 28.9 years old；Age 20-38 year in control group, average age are 28.5 years old.Two groups the age, The course of disease, coincident with severity degree of condition and adjoint disease etc. compare, and have comparativity.
2. treatment method.
2.1 treatment group：Take the decoction or capsule of the present invention, decoction：Every dose of 100mL, early daily, late 2 times orally, often Secondary 100 mL；Capsules/tablets/pill：Every capsules/tablets/ball contains traditional Chinese medicine powder 0.12g of the present invention, daily early, evening 2 times, and every time 2 ~ 8 Grain；Injection：Every contains traditional Chinese medicine powder 0.8g of the present invention, daily sooner or later each one；Avoid eating pungent, peppery, sour, cold, greasy, wine tea etc.；10 It is a course for the treatment of, and the general 3-10 course for the treatment of will significantly improve, and dosage can be according to patient age, body weight, symptom and serious Degree etc. makes the appropriate adjustments.
2.2 control group：Take clomiphene（Clomiphene citrate）, fine jade it is peaceful（Progesterone capsule and pill）, Da Futong（Bend pregnant in ground Ketone）, one hundred not booth (bromocriptine methanesulfonate piece), parlodel tablet etc., avoid eating pungent, peppery, sour, cold, greasy, wine tea etc..
3. criterion of therapeutical effect and treatment results.
3.1 standard references《Clinical disease diagnosis is according to healing improvement standard》It is defined below standard：Criterion of cure is 2 years Inside do not become pregnant person and relevant laboratory examination returns to normal；Though effective standard is not become pregnant, the symptom relevant with this disease, body Sign and laboratory examination have improvement；Null criterion is symptom, sign and laboratory examination without improvement.
3.2 two groups of patient's curative effects compare, and are shown in Table 1
From table 1, in 100 patients for the treatment of group, 80 are cured, effective 18, invalid 2, total effective rate 98%； In 100 patients of control group, healing 24, effective 23, invalid 53, total effective rate 47%.
1 two groups of patient's curative effects of table compare.
Group Cure Effectively It is invalid Total effective rate
Treatment group（100） 80 18 2 98%
Control group（100） 24 23 53 47%
3.3 safety indexes are observed
The general physical examination project of two groups of patients, the inspection of blood urine stool routine, cardiac inspection etc. are equal before and after this clinical observation treatment Without significant change.During observation, two groups do not occur serious adverse events during this clinical observation, pretherapy and post-treatment hepatic and renal function and Blood routine index of correlation is without significant difference.
It can be seen that medicine of the invention can more significantly improve irregular menstruation, small distention and fullness in the abdomen, controlling of failing to be impregnated for a long time than traditional remedies More effect, pregnancy rate is high, occurs without secondary phenomenon, and has no side effect, and patient compliance is good, has actual clinical meaning.

Claims (4)

1. a kind of treat irregular menstruation, small distention and fullness in the abdomen, the medicine to fail to be impregnated for a long time, it is characterised in that it is matched by following weight Medicament made of raw material：Radix Angelicae Sinensis 6 ~ 30, the radix paeoniae rubrathe 10 ~ 25, cultivated land 10 ~ 25, Radix Codonopsis 5 ~ 25, sweet potato 5 ~ 30, the bighead atractylodes rhizome 6 ~ 25, Poria cocos 6 ~ 25th, radix glycyrrhizae 5 ~ 30, rhizoma cyperi 5 ~ 25, Ligusticum wallichii 5 ~ 20, Chinese cassia tree 5 ~ 20, the red sage root 5 ~ 20, folium artemisiae argyi 5 ~ 20, safflower 5 ~ 15, fructus amomi 5 ~ 15, dry Ginger 3 ~ 25, jujube 10 ~ 50.
2. treatment irregular menstruation, small distention and fullness in the abdomen, the medicine to fail to be impregnated for a long time as claimed in claim 1, it is characterised in that each raw material Weight proportion be：Radix Angelicae Sinensis 10 ~ 25, the radix paeoniae rubrathe 12 ~ 20, cultivated land 10 ~ 22, Radix Codonopsis 8 ~ 20, sweet potato 8 ~ 25, the bighead atractylodes rhizome 8 ~ 20, Poria cocos 10 ~ 20th, radix glycyrrhizae 8 ~ 25, rhizoma cyperi 8 ~ 22, Ligusticum wallichii 8 ~ 18, Chinese cassia tree 7 ~ 16, the red sage root 8 ~ 16, folium artemisiae argyi 8 ~ 15, safflower 5 ~ 12, fructus amomi 5 ~ 12, dry Ginger 5 ~ 20, jujube 12 ~ 40.
3. treatment irregular menstruation, small distention and fullness in the abdomen, the medicine to fail to be impregnated for a long time as claimed in claim 1, it is characterised in that each raw material Weight proportion be：Radix Angelicae Sinensis 12 ~ 20, the radix paeoniae rubrathe 12 ~ 18, cultivated land 10 ~ 18, Radix Codonopsis 10 ~ 16, sweet potato 10 ~ 20, the bighead atractylodes rhizome 12 ~ 18, Poria cocos 12 ~ 18, radix glycyrrhizae 10 ~ 20, rhizoma cyperi 12 ~ 18, Ligusticum wallichii 10 ~ 15, Chinese cassia tree 10 ~ 15, the red sage root 10 ~ 15, folium artemisiae argyi 9 ~ 12, safflower 8 ~ 10, sand Benevolence 8 ~ 10, rhizoma zingiberis 8 ~ 15, jujube 15 ~ 30.
4. treatment irregular menstruation, small distention and fullness in the abdomen, the medicine to fail to be impregnated for a long time as claimed in claim 1, it is characterised in that each raw material Weight proportion be：Radix Angelicae Sinensis 15, the radix paeoniae rubrathe 15, cultivated land 15, Radix Codonopsis 15, sweet potato 15, the bighead atractylodes rhizome 15, Poria cocos 15, radix glycyrrhizae 15, rhizoma cyperi 15, Ligusticum wallichii 12, Chinese cassia tree 12, the red sage root 12, folium artemisiae argyi 10, safflower 9, fructus amomi 9, rhizoma zingiberis 10 ~ 15, jujube 20 ~ 30.
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CN1628840A (en) * 2004-08-17 2005-06-22 石春荣 Medicine for promoting ovulation and aiding pregnancy
CN103341004A (en) * 2013-06-27 2013-10-09 柳晖 Chinese medicine composition for treating delayed menstrual cycle

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CN1628840A (en) * 2004-08-17 2005-06-22 石春荣 Medicine for promoting ovulation and aiding pregnancy
CN103341004A (en) * 2013-06-27 2013-10-09 柳晖 Chinese medicine composition for treating delayed menstrual cycle

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