CN104383349A - Drug for postoperative recovery of bladder cancer and preparation method of drug for postoperative recovery of bladder cancer - Google Patents

Drug for postoperative recovery of bladder cancer and preparation method of drug for postoperative recovery of bladder cancer Download PDF

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CN104383349A
CN104383349A CN201410749008.8A CN201410749008A CN104383349A CN 104383349 A CN104383349 A CN 104383349A CN 201410749008 A CN201410749008 A CN 201410749008A CN 104383349 A CN104383349 A CN 104383349A
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bladder cancer
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吴翠霞
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Abstract

The invention provides a drug for postoperative recovery of the bladder cancer and a preparation method of the drug for postoperative recovery of the bladder cancer. The drug for postoperative recovery of the bladder cancer consists of an orally taken capsule and externally used infusion decoction, wherein the active ingredients of the orally taken capsule are prepared from the following raw materials in parts by weight: 4-8 parts of donkey-hide gelatin, 10-30 parts of ginseng, 15-25 parts of ganoderma lucidum, 3-6 parts of resina liquidamberis, 10-15 parts of lalang grass rhizome, 8-15 parts of tuber fleeceflower stems, 10-20 parts of longan pulp and 12-24 parts of polyporus umbellatus; the active ingredients of the externally-used infusion decoction are prepared from the following raw materials in parts by weight: 6-18 parts of common camptotheca fruits, 30-60 parts of jasminum elongatum, 9-18 parts of radix sophorae flavescentis, 30-60 parts of hedyotis diffusa, 16-30 parts of pseudo-ginseng and 6-12 parts of bufonis venenum. The drug for postoperative recovery of the bladder cancer disclosed by the invention has the functions of warm-reinforcing and conditioning a body by being orally taken, dissipating stasis and treating the cancer by being externally used and infused, can be internally and externally used to dissipate stasis and reinforce warm, and can be internally and externally used to strengthen vital qi to eliminate pathogenic factor. The drug for postoperative recovery of the bladder cancer disclosed by the invention can be used for effectively solving the problem that the postoperative recovery of the bladder cancer is difficult and the bladder cancer easily relapses.

Description

A kind of medicine for bladder cancer post-operative recovery and preparation method thereof
Invention field
The present invention relates to the field of Chinese medicines, particularly relating to a kind of medicine for treating recovery after Urothelial Carcinoma of Bladder resection operation.
Background technology
In bladder cancer, more than 80% is Urothelial Carcinoma of Bladder, refers to the malignant tumor in bladder mucosa, account for first of China's Genitourinary system sickness rate, and its sickness rate is only second to carcinoma of prostate in west, occupies second.Urothelial Carcinoma of Bladder bladder cancer is divided into non-Myometrial involvement bladder transitional cell carcinoma and Myometrial involvement bladder transitional cell carcinoma, can betide any age, even child, and male bladder cancer morbidity is 3 ~ 4 times of women.
Non-Myometrial involvement bladder transitional cell carcinoma patient many employings underwent transurethral resection of bladder tumor, but patient's postoperative recurrence of about 70%.Namely Myometrial involvement bladder transitional cell carcinoma patient many employings radial cystectomy art is performed the operation and is removed whole bladder treatment, and five year survival rate is 65%.But a lot of conditions of patients and health are difficult to implement radial cystectomy art or refuse this selection, adopt chemotherapy or partial cystectomy.Western medicine perfusion or chemotherapeutic efficacy and side effect equally can not be fully up to expectations, such as, in the patient 5 years using bacillus calmette-guerin vaccine (Bacillus Calmette-Gu é rin) to treat non-muscle invasive bladder cancer, relapse rate reaches more than 50%, more than 80% is reached to the crash rate of patients with recurrent repetitive therapy again, and cause greatly patient can not adhere to treating due to side effect, affect the treatment.Partial cystectomy has equally and has a big risk, and the obvious shortcoming of side effect, its effective percentage is only 45%.And the long-time interior weak anemia of postoperative patients, pain difficulty peace, lassitude, many secondary hematuria, inflammation even infect, and physical recovery is difficult or be difficult to recover.
Summary of the invention
For solveing the technical problem, reached the postoperative object suppressing recurrence, treatment recovery of bladder cancer by Comprehensive Treatment, the following technical scheme of the invention process:
For a medicine for bladder cancer post-operative recovery, pour into decoction two parts by oral capsule and external and form; The raw material composition of oral capsule drug containing effective ingredient and parts by weight are: 4 ~ 8 parts, Colla Corii Asini, Radix Ginseng 10 ~ 30 parts, Ganoderma lucidum (Leyss. Ex Fr.) Karst. 15 ~ 25 parts, Resina Liquidambaris 3 ~ 6 parts, Rhizoma Imperatae 10 ~ 15 parts, Caulis Polygoni Multiflori 8 ~ 15 parts, Polyporus 12 ~ 24 parts, Arillus Longan 10 ~ 20 parts; Raw material composition and the parts by weight of external perfusion decoction drug containing effective ingredient are: Fructus Camptothecae Acuminatae 6 ~ 18 parts, Herba Oxalidis strictae 30 ~ 60 parts, Radix Sophorae Flavescentis 9 ~ 18 parts, Hedyotidis Diffusae 30 ~ 60 parts, Hirudo 6 ~ 18 parts, Radix Notoginseng 16 ~ 30 parts, Venenum Bufonis 6 ~ 12 parts.
Preferably, oral capsule drug containing effective ingredient raw material composition and parts by weight be: 6 parts, Colla Corii Asini, Radix Ginseng 20 parts, Ganoderma lucidum (Leyss. Ex Fr.) Karst. 20 parts, Resina Liquidambaris 5 parts, Rhizoma Imperatae 12 parts, Caulis Polygoni Multiflori 10 parts, Polyporus 20 parts, Arillus Longan 18 parts; Raw material composition and the parts by weight of external perfusion decoction drug containing effective ingredient are: Fructus Camptothecae Acuminatae 15 parts, Herba Oxalidis strictae 45 parts, Radix Sophorae Flavescentis 13 parts, Hedyotidis Diffusae 45 parts, Radix Notoginseng 25 parts, Venenum Bufonis 8 parts.
Described bladder cancer is postoperative to be referred to: after carrying out underwent transurethral resection of bladder tumor or bladder cancer partial cystectomy week age; Bladder cancer is Urothelial Carcinoma of Bladder.
For a preparation method for the medicine of bladder cancer post-operative recovery, prepare two parts by oral capsule preparation and external perfusion decoction and form.
Oral capsule preparation comprises following processing step:
Baking of being useed force by Colla Corii Asini is sallow to surface, and cool, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
Ganoderma lucidum (Leyss. Ex Fr.) Karst., Resina Liquidambaris are picked clean impurity, and sieve shakeout soil, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
Entered by longan fruit in boiling water and boil 5 ~ 10 minutes, pull out and spread, make moisture loss, slow fire bakes diel, then strips aril: dry, and pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
Radix Ginseng, Rhizoma Imperatae, Caulis Polygoni Multiflori are picked clean impurity, and clean, micro-profit, cutting, adds the yellow wine of four times of weight, boils rear continuation immersion 2 ~ 4 hours, gets and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 1 ~ 2 hour, get and boil liquid; Merge twice gained and boil liquid, heating evaporation concentrates the thick paste being cooled to relative density 1.25 ~ 1.30 under 30 DEG C of environment, for subsequent use;
By the fine powder of step (1) ~ (3) gained, mix with the thick paste obtained by step (4), add after supplementary product starch stirs, rapid freeze-drying makes microgranule, loads in No. 0 capsule, is prepared as capsule product.
The preparation of external perfusion decoction comprises following processing step:
Fructus Camptothecae Acuminatae, Herba Oxalidis strictae, Radix Sophorae Flavescentis, Hedyotidis Diffusae, Radix Notoginseng, Venenum Bufonis are pulverized together, adds the yellow wine of four times of weight, boil rear continuation immersion 1 ~ 3 hour, get and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 1 ~ 2 hour, get and boil liquid; Merge twice gained and boil liquid, filter, heating distillation and concentration, to 3 ~ 4 times of crude drug weight, again filters and get final product.
Usage and consumption are: oral capsule, sooner or later service once, warm water delivery service after meal, adult, each 200mg ~ 450mg, children's, each 3 ~ 8mg of per kilogram of body weight; External perfusion decoction, before perfusion, 2h prohibits drinking-water, drained of urine, per urethra irrigation bladder, retention bladder time 0.5 ~ 2h; Adult, weekly twice, each 200 ~ 400ml, children's, once in a week, each by per kilogram of body weight 6 ~ 10ml administration; Be used in conjunction 6 months; Later external perfusion decoction monthly pours into once, and oral capsule still sooner or later services once each dosage and reduces by half, and is used in conjunction 1 year, the total a year and a half course for the treatment of.
The property of medicine of the present invention's Chinese medicine used is: Colla Corii Asini: sweet in the mouth; Property is put down.Return liver; Lung; Kidney channel.Enrich blood, hemostasis, YIN nourishing, moisturizes.Cure mainly syndrome of deficiency of blood; Asthenia is spat blood; Spit blood; Hematuria; Have blood in stool; Dysentery; Gestation hemorrhage; Metrorrhagia; The vexed insomnia of the deficiency of YIN; Deficiency of the lung bath is coughed; The convulsion of stirring-up of pathogenic wind in the interior resulting from deficiency is fainted tic." detailed outline " carries: " Colla Corii Asini, will just enrich blood and liquid greatly, therefore can lung heat clearing tonifying YIN and control all cards." modern medicine study confirms, Colla Corii Asini nourishing blood effect is strong, and curative effect is better than chalybeate, can shock, has positive calcium balance effect, and is beneficial to vitamin E absorption.Radix Ginseng: bitter in the mouth; Slightly warm in nature.Return lung; The spleen heart; Kidney channel.Strongly invigorating primordial QI; Invigorating the spleen to benefit the lung; Promoting the production of body fluid to quench thirst; Benefit of calming the nerves is short.Cure mainly impairment caused by overstrain deficient; Lack of appetite; Asthenia; Food is told in regurgitation; Stool lingering diarrhea; Empty cough with asthma is urged; Spontaneous perspiration sudden collapse; Palpitation with fear; Forgetful; Dizziness and headache; Sexual impotence; Frequent micturition; Quench one's thirst; Woman uterine bleeding; Children's's intermittent infantile convulsion; Prolonged deficiency is not multiple; The card of qi-blood-body fluid deficiency.Modern medicine study confirms, Radix Ginseng energy endocrine regulation, strengthens body to the resistance of harmful factor, increases the synthesis rate of DNA excision repair, impel cancerous cell to break up again, presses down cancer and takes off cancer." herbal classic " carries: " spasmolytic is throbbed with fear for main tonifying five ZANG-organs, peace spirit, except pathogen, and improving eyesight, happy Fructus Alpiniae Oxyphyllae." Ganoderma lucidum (Leyss. Ex Fr.) Karst.: bitter in the mouth; Property is put down; Nontoxic.Return lung; The heart; Spleen; Kidney channel.Replenishing QI and blood; Tranquilizing mind; Strengthening the spleen and stomach.Cure mainly asthenia; Cardiopalmus; Insomnia; Dizzy; Spiritlessness and weakness; Chronic cough is panted; Coronary heart disease; Pneumosilicosis; Tumor.Modern medicine study confirms, Ganoderma lucidum (Leyss. Ex Fr.) Karst. can obviously ease pain, and promotes the protein of serum, liver and bone marrow and the synthesis of nucleic acid, can strengthen host immune function, have antitumor action by tumor host mediation.Resina Liquidambaris: acrid in the mouth is bitter; Property is put down.Return spleen; Lung; Liver Channel.Expelling wind and activating blood circulation; Removing toxic substances pain relieving; Hemostasis; Granulation promoting.Cure mainly carbuncle; Skin ulcer rash; Scrofula; Toothache; Arthralgia pain; Paralysis; Spit blood; Epistaxis; Traumatic hemorrhage; Chapped skin." herbal classic is met former " carries: " " a thousand pieces of gold " controls spitting bloody pus, gets its exploitation lung qi also." modern medicine study confirmation, Resina Liquidambaris can significantly improve plasmin activity, significantly improves adenosine monophosphate content in platelet internal ring.Rhizoma Imperatae: sweet in the mouth, cold in nature.Return lung, stomach, the heart, urinary bladder channel.Cooling blood for hemostasis; Clearing away heat and promoting production of body fluid; Inducing diuresis for treating stranguria syndrome.Cure mainly heat in blood hemorrhage; Calentura excessive thirst; Gastric heat vomiting; Dyspnea and cough due to lung-heat; The puckery pain of dribbling urination; Edema; Jaundice." herbal classic " carries: " impairment caused by overstrain void is won, invigorating the spleen and replenishing QI, except blood stasis, blood close cold and heat, and diuresis." modern medicine study confirmation, Rhizoma Imperatae has obvious diuresis anastalsis to normal rabbits, has obvious inhibitory action to Fu Shi and sonne bacillus.Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is put down.GUIXIN, Liver Channel.Tranquilizing by nourishing the heart, dispel the wind, dredging collateral.Insomnia, dreaminess, blood deficiency, general pain; Numbness of the skin; Rheumatic arthralgia; Rubella pruritus." detailed outline " carries: " wind skin ulcer scabies is had an itch, and decocts soup bathing." Arillus Longan: sweet in the mouth is warm in nature.GUIXIN, kidney, liver, spleen channel.Cure mainly the palpitation with fear caused by deficiency of both the heart and spleen, insufficiency of vital energy and blood; Palpitation with a distress feeling; Insomnia; Forgetful; Blood deficiency and yellow complexion; Have through uncomfortable; Metrorrhagia." herbal classic " carries: " main the five internal organs pathogen, An Zhi, anorexia, take strong soul for a long time, clever." modern medicine study confirmation, Arillus Longan has inhibitory action to Microsporon audouini, and has calmness and digestion promoting function.Polyporus: slightly sweet flavor, property is put down.Return spleen, kidney, urinary bladder channel.Diuresis eliminating dampness by diuresis.Cure mainly dysuria; Edema distension; Foot gas; Have loose bowels; Stranguria with turbid discharge; Leukorrhagia." detailed outline " carries: " Polyporus is light oozes, gas lift and falling, therefore can open meals reason, diuresis." modern medicine study confirms, the diuresis of Polyporus energy, enhancing immunity, anticancerly presses down cancer, N-butyl-N-(4-hydroxyl butyl) nitrosamine is caused to rat bladder cancer and has obvious inhibitory action, and without obvious toxic-side effects.Fructus Camptothecae Acuminatae: bitter in the mouth, pungent; Cold in nature, poisonous.Return spleen, stomach Liver Channel.Heat-clearing and toxic substances removing; Dispersing accumulated pathogens to resolve the mass.Cure mainly esophageal carcinoma; Carcinoma of gastric cardia; Gastric cancer; Intestinal cancer; Hepatocarcinoma; Leukemia; Psoriasis; Skin ulcer swells.Modern medicine study confirms, the bad oncocyte DNA structure of camptothecine energy limb contained by Fructus Camptothecae Acuminatae, suppresses archaeal dna polymerase again and affects copying of DNA, all can suppress, have immunosuppressive action to various implanted solid tumor growth.Herba Oxalidis strictae: mildly bitter flavor, cool in nature.Heat clearing away; Dampness removing; Removing toxic substances.Cure mainly damp-heat dysentery; Stomachache tenesmus; Beriberoid pyretic arthralgia; Extremity swell and ache; Pestilence scrofula; Skin ulcer scabies." south of the Five Ridges gather medicinal herbs record " carries: " control abdominal pain due to damp-heat, stool is smooth, decoction.Decoct soup and wash skin ulcer scabies." Radix Sophorae Flavescentis: bitter in the mouth, cold in nature.Return liver; Kidney; Large intestine; Small intestine meridian; Bladder; Heart channel.Heat clearing and damp drying; Wind dispelling insecticide.Cure mainly damp-heat dysentery; Discharging fresh blood stool; Jaundice; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; Scabies; Leprosy; Skin pruritus; Noxious dampness skin infection." herbal classic " carries: " jaundice, drowns and has the heeltap, relieve oedema or abdominal distension through diuresis or purgation for main stagnation of QI in chest and abdomen, lumps in the chest and abdomen, except carbuncle, and invigorating middle warmer, improving eyesight arresting lacrimation." modern medicine study confirmation, contained by Radix Sophorae Flavescentis, matrine has active anticancer, and Radix Sophorae Flavescentis energy leukocyte increasing content, calm emotions.Hedyotidis Diffusae: bitter but sweet flavor; Cold in nature, nontoxic.GUIXIN; Liver; Spleen; Large intestine channel.Heat-clearing and toxic substances removing; Dampness removing.Cure mainly dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; Cancerous protuberance." Quanzhou book on Chinese herbal medicine " carries: " heat clearing away dissipating blood stasis, eliminating carbuncle detoxifies.Control ulcer sores, scrofula.Again can lung heat clearing fire, eliminating the pathogens from the lung heat.Control lung-heat dyspnea with rapid and short breath, cough against uncomfortable in chest." modern medicine study confirmation, Hedyotidis Diffusae has antibacterial and anti-inflammation functions, and in vitro, when being equivalent to crude drug 6g/ml, has comparatively high inhibition effect to the tumor cell of acute lymphoblastic type, granulocyte type, monocyte type and chronic granulocyte type.Radix Notoginseng: sweet and slightly bitter taste, warm in nature.Enter liver, stomach, large intestine channel.Hemostasis dissipating blood stasis, subduing swelling and relieving pain.Cure mainly haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain." detailed outline " carries: " hemostasis, loose blood, analgesic therapy.Gold sword arrow wound, fall and flutter flogging injury, blood goes out more than person, chews rotten painting, or for mixing it in end, namely its blood stop.Also main haematemesis, epistaxis, hematochezia, dysentery, metrorrhagia, incessant menorrhea, puerperal stagnant blood not under, blood transport, blood pain, Akamu, carbuncle, tiger stings, all diseases of snakebite." modern medicine study confirmation; Radix Notoginseng contains the active component of multiple dammarane type four-ring triterpenoid Saponin as ginsenoside, arasaponin, Herb Gynostemmae Pentaphylli glycoside etc.; and the active ingredients such as effective ingredient dencichine, anticancer polyacetylene composition panaxytiol of stopping blooding; coronary artery blood flow can be increased, decreased heart rate, reduce myocardial oxygen consumption; resist because of the blood pressure rising caused by pituitrin, coronary artery contraction; stop blooding, anticancer, the accumulation of promotion white mice liver glycogen.Venenum Bufonis: acrid in the mouth; Warm in nature, poisonous.GUIXIN warp.Cure mainly carbuncle furuncle; Laryngopharynx swelling and pain; Wind carious pain; Gingiva swells rotten; Acute filthy disease is suffered from abdominal pain." detailed outline " carries: control carbuncle on the back and treat skin ulcer, all dislike swollen.Modern medicine study confirms, Venenum Bufonis has obvious diuresis and good pain relieving surface anesthetic effect.
The present invention adopts temperature compensation for oral administration to nurse one's health, external perfusion dissipating blood stasis go cancer, inside and outside be harmonious, the aim of strengthening vital QI to eliminate pathogenic factors.In side, Polyporus, Fructus Camptothecae Acuminatae, Radix Sophorae Flavescentis, Hedyotidis Diffusae is compatible, can effective anticancer, reduce tumor cell viability, even kill cancerous cell; Polyporus, Radix Ginseng, Ganoderma lucidum (Leyss. Ex Fr.) Karst., Radix Notoginseng are compatible, can endocrine regulation, strengthen body immunity, anticancer de-cancer; Two sides group mutually, inside and outsidely doublely to execute, and can play the effect effectively reducing relapse rate.External prescription Fructus Camptothecae Acuminatae, Herba Oxalidis strictae, Radix Sophorae Flavescentis, Hedyotidis Diffusae and prescription Rhizoma Imperatae for oral administration, Caulis Polygoni Multiflori are compatible, can clearing away heat-damp and promoting diuresis, anti-inflammation; Help mutually with Radix Ginseng, Ganoderma lucidum (Leyss. Ex Fr.) Karst., Arillus Longan, Venenum Bufonis, can subside a swelling and relieve the pain, centering is calmed the nerves, and diuresis eliminating dampness by diuresis, play bladder inwall oneself cleaning action, alleviate external side effect.Radix Notoginseng, Resina Liquidambaris, Rhizoma Imperatae removing blood stasis and activating blood flow, hemostasia and promoting granulation; Colla Corii Asini, Radix Ginseng, Arillus Longan are compatible, righting can train unit, benefiting qi and nourishing blood; Two sides group mutually, loose benefit combines, and unlikely excessively raw.And external perfusion done by Fructus Camptothecae Acuminatae, Radix Sophorae Flavescentis, Hedyotidis Diffusae anti-inflammatory agent, topical, greatly reduces the antagonism to enhancing immunity medicine.Oral administration and externally, all medicine compatibilities, energy endocrine regulation, improves immunity, suppresses and even eliminates residual cancer cells, effectively preventing cancer return; Removing blood stasis and activating blood flow, benefiting qi and nourishing blood, anti-inflammation, analgesic therapy is calmed the nerves, and accelerates patient's post-operative recovery, reduces the risk of recurrence further, remarkable through clinical efficacy, is suitable for postoperative the resuming treatment of bladder cancer.
The preparation method provided is simple, reasonable in design.Go cancer by anticancer, and anti-inflammatory drug is made as external perfusion medicament, alleviates the impact of drug side effect on patient and endo-medicine drug effect.Endo-medicine taking convenience, is convenient to patient's long-term taking simultaneously.The combination of inner and outside, avoids the shortcoming of single drug and inconvenience.
Detailed description of the invention
Below in conjunction with embodiment and case, further explaination is done to the present invention.
Embodiment 1
The raw material composition of oral capsule drug containing effective ingredient of the present invention and parts by weight are: 6 grams, Colla Corii Asini, Radix Ginseng 20 grams, Ganoderma lucidum (Leyss. Ex Fr.) Karst. 20 grams, Resina Liquidambaris 5 grams, Rhizoma Imperatae 12 grams, Caulis Polygoni Multiflori 10 grams, Arillus Longan 18 grams, Polyporus 20 grams; Raw material composition and the parts by weight of external perfusion decoction drug containing effective ingredient are: Fructus Camptothecae Acuminatae 15 grams, Herba Oxalidis strictae 45 grams, Radix Sophorae Flavescentis 13 grams, Hedyotidis Diffusae 45 grams, Radix Notoginseng 25 grams, Venenum Bufonis 8 grams.
The preparation method step of medicine of the present invention is:
Oral capsule preparation comprises following processing step:
(1) baking of being useed force by Colla Corii Asini is sallow to surface, and cool, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(2) Ganoderma lucidum (Leyss. Ex Fr.) Karst., Resina Liquidambaris are picked clean impurity, sieve shakeout soil, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(3) entered in boiling water by longan fruit to boil 8 minutes, pull out and spread, make moisture loss, slow fire bakes diel, then strips aril: dry, and pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(4) Radix Ginseng, Rhizoma Imperatae, Caulis Polygoni Multiflori are picked clean impurity, clean, micro-profit, cutting, adds the yellow wine of four times of weight, boils rear continuation immersion 3 hours, gets and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 1.5 hours, get and boil liquid; Merge twice gained and boil liquid, heating evaporation concentrates the thick paste being cooled to relative density 1.27 under 30 DEG C of environment, for subsequent use;
(5) by the fine powder of step (1) ~ (3) gained, mix with the thick paste obtained by step (4), add after supplementary product starch stirs, rapid freeze-drying makes microgranule, loads in No. 0 capsule, is prepared as capsule product.
The preparation of external perfusion decoction comprises following processing step:
Fructus Camptothecae Acuminatae, Herba Oxalidis strictae, Radix Sophorae Flavescentis, Hedyotidis Diffusae, Radix Notoginseng, Venenum Bufonis are pulverized together, adds the yellow wine of four times of weight, boil rear continuation immersion 2 hours, get and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 1.5 hours, get and boil liquid; Merge twice gained and boil liquid, filter, heating distillation and concentration, to 3.5 times of crude drug weight, again filters and get final product.
Usage and consumption are: oral capsule, sooner or later service once, warm water delivery service after meal, adult, each 300mg, children's, each 6mg of per kilogram of body weight; External perfusion decoction, before perfusion, 2h prohibits drinking-water, drained of urine, per urethra irrigation bladder, retention bladder time 1h; Adult, weekly twice, each 300ml, children's, once in a week, each by per kilogram of body weight 8ml administration; Be used in conjunction 6 months, later external perfusion decoction monthly pours into once, and each dosage of oral capsule reduces by half, and is used in conjunction 1 year, the total a year and a half course for the treatment of.
Embodiment 2
The raw material composition of oral capsule drug containing effective ingredient of the present invention and parts by weight are: 4 grams, Colla Corii Asini, Radix Ginseng 15 grams, Ganoderma lucidum (Leyss. Ex Fr.) Karst. 25 grams, Resina Liquidambaris 6 grams, Rhizoma Imperatae 12 grams, Caulis Polygoni Multiflori 8 grams, Arillus Longan 10 grams, Polyporus 12 grams; Raw material composition and the parts by weight of external perfusion decoction drug containing effective ingredient are: Fructus Camptothecae Acuminatae 10 grams, Herba Oxalidis strictae 30 grams, Radix Sophorae Flavescentis 9 grams, Hedyotidis Diffusae 40 grams, Radix Notoginseng 16 grams, Venenum Bufonis 6 grams.
The preparation method step of medicine of the present invention is:
Oral capsule preparation comprises following processing step:
(1) baking of being useed force by Colla Corii Asini is sallow to surface, and cool, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(2) Ganoderma lucidum (Leyss. Ex Fr.) Karst., Resina Liquidambaris are picked clean impurity, sieve shakeout soil, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(3) entered in boiling water by longan fruit to boil 10 minutes, pull out and spread, make moisture loss, slow fire bakes diel, then strips aril: dry, and pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(4) Radix Ginseng, Rhizoma Imperatae, Caulis Polygoni Multiflori are picked clean impurity, clean, micro-profit, cutting, adds the yellow wine of four times of weight, boils rear continuation immersion 2 hours, gets and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 1 hour, get and boil liquid; Merge twice gained and boil liquid, heating evaporation concentrates the thick paste being cooled to relative density 1.25 under 30 DEG C of environment, for subsequent use;
(5) by the fine powder of step (1) ~ (3) gained, mix with the thick paste obtained by step (4), add after supplementary product starch stirs, rapid freeze-drying makes microgranule, loads in No. 0 capsule, is prepared as capsule product.
The preparation of external perfusion decoction comprises following processing step:
Fructus Camptothecae Acuminatae, Herba Oxalidis strictae, Radix Sophorae Flavescentis, Hedyotidis Diffusae, Radix Notoginseng, Venenum Bufonis are pulverized together, adds the yellow wine of four times of weight, boil rear continuation immersion 1 hour, get and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 2 hours, get and boil liquid; Merge twice gained and boil liquid, filter, heating distillation and concentration, to 3 times of crude drug weight, again filters and get final product.
Usage and consumption are: oral capsule, sooner or later service once, warm water delivery service after meal, adult, each 200mg, children's, each 5mg of per kilogram of body weight; External perfusion decoction, before perfusion, 2h prohibits drinking-water, drained of urine, per urethra irrigation bladder, retention bladder time 2h; Adult, weekly twice, each 350ml, children's, once in a week, each by per kilogram of body weight 6ml administration; Be used in conjunction 6 months, later external perfusion decoction monthly pours into once, and each dosage of oral capsule reduces by half, and is used in conjunction 1 year, the total a year and a half course for the treatment of.
Embodiment 3
The raw material composition of oral capsule drug containing effective ingredient of the present invention and parts by weight are: 8 grams, Colla Corii Asini, Radix Ginseng 10 grams, Ganoderma lucidum (Leyss. Ex Fr.) Karst. 15 grams, Resina Liquidambaris 3 grams, Rhizoma Imperatae 10 grams, Caulis Polygoni Multiflori 12 grams, Arillus Longan 20 grams, Polyporus 24 grams; Raw material composition and the parts by weight of external perfusion decoction drug containing effective ingredient are: Fructus Camptothecae Acuminatae 6 grams, Herba Oxalidis strictae 60 grams, Radix Sophorae Flavescentis 10 grams, Hedyotidis Diffusae 30 grams, Radix Notoginseng 30 grams, Venenum Bufonis 10 grams.
The preparation method step of medicine of the present invention is:
Oral capsule preparation comprises following processing step:
(1) baking of being useed force by Colla Corii Asini is sallow to surface, and cool, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(2) Ganoderma lucidum (Leyss. Ex Fr.) Karst., Resina Liquidambaris are picked clean impurity, sieve shakeout soil, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(3) entered in boiling water by longan fruit to boil 7 minutes, pull out and spread, make moisture loss, slow fire bakes diel, then strips aril: dry, and pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(4) Radix Ginseng, Rhizoma Imperatae, Caulis Polygoni Multiflori are picked clean impurity, clean, micro-profit, cutting, adds the yellow wine of four times of weight, boils rear continuation immersion 3.5 hours, gets and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 2 hours, get and boil liquid; Merge twice gained and boil liquid, heating evaporation concentrates the thick paste being cooled to relative density 1.30 under 30 DEG C of environment, for subsequent use;
(5) by the fine powder of step (1) ~ (3) gained, mix with the thick paste obtained by step (4), add after supplementary product starch stirs, rapid freeze-drying makes microgranule, loads in No. 0 capsule, is prepared as capsule product.
The preparation of external perfusion decoction comprises following processing step:
Fructus Camptothecae Acuminatae, Herba Oxalidis strictae, Radix Sophorae Flavescentis, Hedyotidis Diffusae, Radix Notoginseng, Venenum Bufonis are pulverized together, adds the yellow wine of four times of weight, boil rear continuation immersion 3 hours, get and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 1.6 hours, get and boil liquid; Merge twice gained and boil liquid, filter, heating distillation and concentration, to 3.7 times of crude drug weight, again filters and get final product.
Usage and consumption are: oral capsule, sooner or later service once, warm water delivery service after meal, adult, each 350mg, children's, each 3mg of per kilogram of body weight; External perfusion decoction, before perfusion, 2h prohibits drinking-water, drained of urine, per urethra irrigation bladder, retention bladder time 0.5h; Adult, weekly twice, each 400ml, children's, once in a week, each by per kilogram of body weight 10ml administration; Be used in conjunction 6 months, later external perfusion decoction monthly pours into once, and each dosage of oral capsule reduces by half, and is used in conjunction 1 year, the total a year and a half course for the treatment of.
Embodiment 4
The raw material composition of oral capsule drug containing effective ingredient of the present invention and parts by weight are: 7 grams, Colla Corii Asini, Radix Ginseng 30 grams, Ganoderma lucidum (Leyss. Ex Fr.) Karst. 18 grams, Resina Liquidambaris 4 grams, Rhizoma Imperatae 15 grams, Caulis Polygoni Multiflori 15 grams, Arillus Longan 15 grams, Polyporus 20 grams; Raw material composition and the parts by weight of external perfusion decoction drug containing effective ingredient are: Fructus Camptothecae Acuminatae 18 grams, Herba Oxalidis strictae 40 grams, Radix Sophorae Flavescentis 18 grams, Hedyotidis Diffusae 60 grams, Radix Notoginseng 22 grams, Venenum Bufonis 12 grams.
The preparation method step of medicine of the present invention is:
Oral capsule preparation comprises following processing step:
(1) baking of being useed force by Colla Corii Asini is sallow to surface, and cool, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(2) Ganoderma lucidum (Leyss. Ex Fr.) Karst., Resina Liquidambaris are picked clean impurity, sieve shakeout soil, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(3) entered in boiling water by longan fruit to boil 5 minutes, pull out and spread, make moisture loss, slow fire bakes diel, then strips aril: dry, and pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use.
(4) Radix Ginseng, Rhizoma Imperatae, Caulis Polygoni Multiflori are picked clean impurity, clean, micro-profit, cutting, adds the yellow wine of four times of weight, boils rear continuation immersion 4 hours, gets and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 1.6 hours, get and boil liquid; Merge twice gained and boil liquid, heating evaporation concentrates the thick paste being cooled to relative density 1.28 under 30 DEG C of environment, for subsequent use;
(5) by the fine powder of step (1) ~ (3) gained, mix with the thick paste obtained by step (4), add after supplementary product starch stirs, rapid freeze-drying makes microgranule, loads in No. 0 capsule, is prepared as capsule product.
The preparation of external perfusion decoction comprises following processing step:
Fructus Camptothecae Acuminatae, Herba Oxalidis strictae, Radix Sophorae Flavescentis, Hedyotidis Diffusae, Radix Notoginseng, Venenum Bufonis are pulverized together, adds the yellow wine of four times of weight, boil rear continuation immersion 2.5, get and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 1 hour, get and boil liquid; Merge twice gained and boil liquid, filter, heating distillation and concentration, to 4 times of crude drug weight, again filters and get final product.
Usage and consumption are: oral capsule, sooner or later service once, warm water delivery service after meal, adult, each 450mg, children's, each 8mg of per kilogram of body weight; External perfusion decoction, before perfusion, 2h prohibits drinking-water, drained of urine, per urethra irrigation bladder, retention bladder time 1.8h; Adult, weekly twice, each 200ml, children's, once in a week, each by per kilogram of body weight 7ml administration; Be used in conjunction 6 months, later external perfusion decoction monthly pours into once, and each dosage of oral capsule reduces by half, and is used in conjunction 1 year, the total a year and a half course for the treatment of.
For inspection curative effect of the present invention, choose 300 examples and carry out bladder cancer postoperative patient, wherein patient 180 example after underwent transurethral resection of bladder tumor, patient 120 example after bladder cancer partial cystectomy.Wherein male 39 example, women 11 example, at 12 ~ 77 years old age, 62 years old mean age, within 50 ~ 70 years old, patient accounts for 82% of sum.
Choice criteria: legs and feet are weak, soreness of the waist and knees; Face is sallow; Lassitude; Bladder pain; Hematuria dysuria.Urinary cytology inspection is abnormal, and carcinoembryonic antigen is abnormal, and it is negative that nuclear matrix protein detects (NMP22 detection) index.
Efficacy determination:
Remarkable: weak alleviation; Spirit is good, bladder pain is alleviated, and lower abdomen is comfortable; Of pink and healthy-looking; Urinate normal; Urinary cytology inspection is normal, and nuclear matrix protein Testing index is negative.
Suppress: weakly to alleviate; Bladder, urodynamic alleviate; The cancer state of an illness obtains part and controls; The part index numbers such as carcinoembryonic antigen make moderate progress.
Invalid: clinical symptoms is without to be clearly better or cancer return increases the weight of.
300 examples follow up a case by regular visits to 14 ~ 35 months, recurrence 46 example, relapse rate 15.3%.
Patient takes oral medicinal herb capsule of the present invention continuously and coordinates external perfusion decoction to treat, and after a year and a half, observe the change of conditions of patients, therapeutic outcome is as follows:
Sum Significantly Alleviate Invalid Total effective rate
Data 300 70(23.3％) 204(68％) 26(8.7％) 91.3％
Below by concrete case, further checking is done to curative effect of medication provided by the invention.
Zhang, female, 16 years old, suffer from superficial bladder cancer, 1 grade, single-shot papilloma, had the base of a fruit, 2cm.Within 2010, to pass through bladder electrotomy, within postoperative one week, start to pour into external of the present invention perfusion decoction, coordinate oral oral capsule medication of the present invention, this month and symptom alleviate, pain relief, after adhere to that medication is more than 2 years, once, all do not find Indexes Abnormality, tumor does not recur so far in check in every 3 months, general with normal person, existing 4 years.
Pan, man, 68 years old, suffers from bladder cancer in 2005, for the first time excision.During check in 2008, urine examination Indexes Abnormality, recurrence in 2010, finds tumor.To pass through bladder electrotomy, and take conventional Chinese medicine and alleviate, curative effect is poor.In January, 2012, tumor reaches 3.5cm, and in cauliflower form, the short base of a fruit, bladder electrotomy of passing through, operation uses Drug therapy of the present invention, medication 16 months after January, and check meeting color is normal, and hematuria, urgent micturition and dysuria are alleviated, and tumor does not recur, drug withdrawal.
High mountain, man, 43 years old, within 2011, seek medical advice because finding hematuria, examine as low level Urothelium carcinoma, bladder electrotomy of passing through at the end of 2011, postoperative perfusion note pirarubicin, pour into the 3rd time and occur frequent micturition, urgent micturition, adhere to again once, occur hematuria, chemical cystitis occurs, so stop filling with first quarter moon, take oral capsule of the present invention.After change perfusion external decoction of the present invention, simultaneously continue cooperation take oral capsule of the present invention.After one month, hematuria disappearance, pain relief.After adhering to a course for the treatment of of treatment, inflammation disappears, and cancer has no recurrence.

Claims (4)

1. for a medicine for bladder cancer post-operative recovery, it is characterized in that: pour into decoction two parts by oral capsule and external and form; The raw material composition of oral capsule drug containing effective ingredient and parts by weight are: 4 ~ 8 parts, Colla Corii Asini, Radix Ginseng 10 ~ 30 parts, Ganoderma lucidum (Leyss. Ex Fr.) Karst. 15 ~ 25 parts, Resina Liquidambaris 3 ~ 6 parts, Rhizoma Imperatae 10 ~ 15 parts, Caulis Polygoni Multiflori 8 ~ 15 parts, Arillus Longan 10 ~ 20 parts, Polyporus 12 ~ 24 parts; Raw material composition and the parts by weight of external perfusion decoction drug containing effective ingredient are: Fructus Camptothecae Acuminatae 6 ~ 18 parts, Herba Oxalidis strictae 30 ~ 60 parts, Radix Sophorae Flavescentis 9 ~ 18 parts, Hedyotidis Diffusae 30 ~ 60 parts, Radix Notoginseng 16 ~ 30 parts, Venenum Bufonis 6 ~ 12 parts.
2. a kind of medicine for bladder cancer post-operative recovery according to claim 1, is characterized in that: pour into decoction two parts by oral capsule and external and form; The raw material composition of oral capsule drug containing effective ingredient and parts by weight are: 6 parts, Colla Corii Asini, Radix Ginseng 20 parts, Ganoderma lucidum (Leyss. Ex Fr.) Karst. 20 parts, Resina Liquidambaris 5 parts, Rhizoma Imperatae 12 parts, Caulis Polygoni Multiflori 10 parts, Polyporus 20 parts, Arillus Longan 18 parts; Raw material composition and the parts by weight of external perfusion decoction drug containing effective ingredient are: Fructus Camptothecae Acuminatae 15 parts, Herba Oxalidis strictae 45 parts, Radix Sophorae Flavescentis 13 parts, Hedyotidis Diffusae 45 parts, Radix Notoginseng 25 parts, Venenum Bufonis 8 parts.
3. a kind of medicine for bladder cancer post-operative recovery according to claim 1 and 2, is characterized in that: described bladder cancer is Urothelial Carcinoma of Bladder.
4. for a preparation method for the medicine of bladder cancer post-operative recovery, it is characterized in that: prepare two parts by oral capsule preparation and external perfusion decoction and form;
Described oral capsule preparation comprises following processing step:
(1) baking of being useed force by Colla Corii Asini is sallow to surface, and cool, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use;
(2) Polyporus, Ganoderma lucidum (Leyss. Ex Fr.) Karst., Resina Liquidambaris are picked clean impurity, sieve shakeout soil, pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use;
(3) entered in boiling water by longan fruit to boil 5 ~ 10 minutes, pull out and spread, make moisture loss, slow fire bakes diel, then strips aril: dry, and pulverizing is ground into powder, crosses 200 order fine powders, for subsequent use;
(4) Radix Ginseng, Rhizoma Imperatae, Caulis Polygoni Multiflori are picked clean impurity, clean, micro-profit, cutting, adds the yellow wine of four times of weight, boils rear continuation immersion 2 ~ 4 hours, gets and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 1 ~ 2 hour, get and boil liquid; Merge twice gained and boil liquid, heating evaporation concentrates the thick paste being cooled to relative density 1.25 ~ 1.30 under 30 DEG C of environment, for subsequent use;
(5) by the fine powder of step (1) ~ (3) gained, mix with the thick paste obtained by step (4), add after supplementary product starch stirs, rapid freeze-drying makes microgranule, loads in No. 0 capsule, is prepared as capsule product;
Described external perfusion decoction preparation comprises following processing step:
Fructus Camptothecae Acuminatae, Herba Oxalidis strictae, Radix Sophorae Flavescentis, Hedyotidis Diffusae, Radix Notoginseng, Venenum Bufonis are pulverized together, adds the yellow wine of four times of weight, boil rear continuation immersion 1 ~ 3 hour, get and boil liquid; In remaining medicinal residues, add the yellow wine of double weight again, boil rear continuation immersion 1 ~ 2 hour, get and boil liquid; Merge twice gained and boil liquid, filter, heating distillation and concentration is to 3 ~ 4 times of crude drug weight.
CN201410749008.8A 2014-12-09 2014-12-09 Drug for postoperative recovery of bladder cancer and preparation method of drug for postoperative recovery of bladder cancer Pending CN104383349A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
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CN106620402A (en) * 2017-03-14 2017-05-10 江志杰 Traditional Chinese medicine composition taken after operation of liver cancer and preparation method thereof
CN106880753A (en) * 2017-03-14 2017-06-23 江志杰 A kind of postoperative use Chinese medicine composition of carcinoma of gallbladder and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101708285A (en) * 2009-07-12 2010-05-19 王人杰 Chinese medicinal composition for treating cancers and preparation method thereof
CN104042926A (en) * 2014-07-10 2014-09-17 崇州市地龙海龙生物制品开发研究所 Method for preparing preparation for treating bladder cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101708285A (en) * 2009-07-12 2010-05-19 王人杰 Chinese medicinal composition for treating cancers and preparation method thereof
CN104042926A (en) * 2014-07-10 2014-09-17 崇州市地龙海龙生物制品开发研究所 Method for preparing preparation for treating bladder cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李雁: "膀胱癌术后发热从湿温论治", 《上海中医药杂志》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106620402A (en) * 2017-03-14 2017-05-10 江志杰 Traditional Chinese medicine composition taken after operation of liver cancer and preparation method thereof
CN106880753A (en) * 2017-03-14 2017-06-23 江志杰 A kind of postoperative use Chinese medicine composition of carcinoma of gallbladder and preparation method thereof

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Application publication date: 20150304