CN104208533B - A kind of medicine for treating psoriasis pustulosa - Google Patents

Abstract

The invention discloses a kind of medicine for treating psoriasis pustulosa, by the 32g of the Radix Astragali 28, the 32g of Semen Coicis 28, the 14g of golden cypress 10, the 32g of the red sage root 28, the 32g of radix scrophulariae 28, the 12g of the root bark of tree peony 8, the 32g of smilax 28, the 12g of cassia twig 8, the 10g of frankincense 6, the 10g of myrrh 6, after the 12g of radix bupleuri 8 is well mixed, extract the active component of Chinese medicine, add water to cook 3 times, 0.5~1 hour every time, merge 3 decocting liquids, filtering, it is condensed into the thick paste that 60 DEG C of relative densities are 1.25~1.3, after 50~60 DEG C are dried, it is crushed to the medicinal powder of 100 mesh, it is fitted into capsule, capsule product is made in sterilization.1.5 grams of every weight of this product.Medicine clearing heat and promoting diuresis of the present invention, eliminating toxic removes purulence, drops the work(of turbid ecchymose removing, treatment psoriasis pustulosa curative effect is fast, short treating period, have no side effect, 80 patients course for the treatment of of drug therapy 3 of the present invention by oral administration, cures 66, improvement 10, invalid 4, effective percentage 95%, cure rate 83%.During medication, have no adverse reaction.

Description

A kind of medicine for treating psoriasis pustulosa

Technical field

It is a kind of medicine for treating psoriasis pustulosa specifically the present invention relates to a kind of medicine for treating psoriasis.

Background technology

Pustular type psoriasis is divided into two types, and a kind of is the general hair style of whole body, and more rare, etiology unknown is fallen ill hurried, Sustainable a few days tension and relaxation hyperpyrexia, with general malaise, weak and arthroncus, occur suddenly in erythema it is general send out shallow yellow-white Sterile pimple, syringe needle, to grain grain size, is just small pieces, and being fused into later in " purulence lake ", several weeks can diffusivity distribution whole body, wrinkle Often there is intertrigo, incrustation in folds in a garment portion, is often extended around the erythema of warts and is fused into the change of erythroderma sample, the visible pimple of mucous membrane, tongue Often there is deeper line in face, claims fluted tongue;A kind of is that the fash of limit office type is limited to palm and vola pedis, symmetrical.At the beginning of metacarpus skin damaged Send out in big hypothenar, later skin damaged gradually expands to the centre of the palm, the back of the hand and finger, foot plantar is apt to occur in the middle part of plantar and inner side, and fash is Faint yellow syringe needle, to the big pimple of grain grain, is not easily broken in groups in symmetry erythema.

Psoriasis pustulosa is also more rare than red integumentary pattern psoriasis, and its state of an illness is more serious, and treatment difficulty is also bigger.At present, have Many is reported to the sick clinical experience, therapeutic effect although closing, really is able to reach that the scheme of special efficacy is not too much more, should The sick most thorny issue is exactly that can still be recurred again after treating, and there is presently no make a breakthrough for this problem.

The content of the invention

The present invention solves the deficiencies in the prior art, and there is provided a kind of short treating period, treatment pustule type silver bits evident in efficacy The medicine of disease.

The medicine of the present invention is prepared by the bulk drug of following ratio of weight and number：

Radix Astragali 28-32 Semen Coicis 28-32 golden cypress 10-14 reds sage root 28-32

Radix scrophulariae 28-32 root bark of tree peony 8-12 smilax 28-32 cassia twig 8-12

Frankincense 6-10 myrrh 6-10 radix bupleuri 8-12.

The preferred weight fraction of the bulk drug is：

The red sage root 30 of 30 Semen Coicis of the Radix Astragali, 30 golden cypress 12

The cassia twig 10 of 30 root bark of tree peony of radix scrophulariae, 10 smilax 30

The radix bupleuri 10 of 8 myrrh of frankincense 8.

After above-mentioned various Chinese medicines are well mixed according to described ratio of weight and number, add water to cook 3 times, 0.5~1 is small every time When, merge 3 decocting liquids, filtering is condensed into the thick paste that 60 DEG C of relative densities are 1.25~1.3, after 50~60 DEG C are dried, crushed To the medicinal powder of 100 mesh, it is fitted into capsule, capsule product is made in sterilization.

It is the enriching the blood to restore normal menstruation of Chinese traditional treatment psoriasis pustulosa mechanism, clearing heat and detoxicating, promoting blood circulation and removing blood stasis.The Radix Astragali in prescription of the present invention, Semen Coicis, smilax tonifying Qi dampness removing eliminating toxic, it is monarch that turbid purulence drops in heat-clearing；Golden cypress, the root bark of tree peony, radix scrophulariae, the red sage root cooling and activating blood row stasis of blood are Minister；Frankincense, myrrh benefiting qi for promoting granulation, detoxification are assistant except purulence；Cassia twig, radix bupleuri qi-regulating establishing-Yang are to make.All medicines share gathers clearing heat and promoting diuresis altogether, Eliminating toxic removes purulence, drops the work(of turbid ecchymose removing.Prescription of the present invention be the mechanism for Chinese traditional treatment psoriasis pustulosa come compatibility, to treatment Psoriasis pustulosa has unique curative effect.

Further to investigate the clinical efficacy of drug therapy psoriasis pustulosa of the present invention, 80 psoriasis pustulosas are selected Patient has carried out clinical observation on the therapeutic effect.

Clinical data：

Outpatient 80 is selected, wherein male 50, female 30, the course of disease 1 year~3 years, 16~65 years old age.

Diagnostic criteria

Diagnosis can be made according to morbidity history, clinical symptoms, medication treatment history and laboratory examination：

Limitation psoriasis pustulosa characteristics of incidence：

1st, it is limited to slap plantar, most faint yellow syringe needles occur in batch for Chang great hypothenars or foot plantar to grain grain size purulence more Blister, substrate flush；

2nd, about ruptured through 1~2 week warts, incrustation, furfur.Occur pimple under the scales of skin that peel off again later, when it is light when weight；

3rd, feel and itch or pain.Sometimes can also there are low-heat or general malaise, nail is often involved, in muddy plump, there is ridge Shape swells；

4th, other positions of patient body Chang Kejian has psoriatic lesion；

5th, some patients are first sent out in palm plantar, are changed into general hair property person after multiple recurrent exerbation.

The characteristics of incidence of generalized pustular psoriasis：

1st, be generally acute onset, can within a few days to several weeks the general hair whole body of warts, first have the potential of intensive needle point size Pimple, purulence lake is fused into quickly；

2nd, whole body everywhere can dermexanthesis, but bend side to be common using pleated portions and four limbs.Sometimes nail matrix may occur in which pimple, Deck is plump muddy；

3rd, hyperpyrexia, painful swelling of joints and general malaise are often accompanied by, blood routine is chemically examined visible leukocyte count and increased；

4th, after warts is dry, decortication immediately is considered to be worth doing, and scurf immediately plays new pimple again after coming off;The course of disease again and again may be used Up to the several months or more long.

In diagnosis, the two mainly general hair property person of difference is with constitutional symptoms such as heating, general malaises, easy secondary red skin Disease etc., and limitation person is typically no.

Treatment method

Oral medicine of the present invention, one time 5, twice a day, once in the morning and once at night.

Criterion of therapeutical effect

Clinical recovery：Warts skin damaged all disappears or regression area>90%；

It is effective：Warts skin damaged regression area 61%~90%；

It is progressive：Warts skin damaged regression area 21%~60%；

It is invalid：Warts skin damaged regression area≤20%.

Treatment results

80 patients course for the treatment of of drug therapy 3 of the present invention by oral administration, cures 66, takes a turn for the better 10, invalid 4, efficient 95%, cure rate 83%.During medication, have no adverse reaction.

Model case

Case one：Bai, female, 56 years old, cluster, grain on the basis of main cause both hands palm and left side sole and several erythema Grain size, superficial milky warts, covers dirty grey scales of skin that peel off scab, remaining medical on January 25th, 2013 June with itch.Patient 1 There is the erythema of nail cover size at left foot before year, cover the grey scales of skin that peel off, with itch.It is medical in community clinic, give compound acetic acid Twice a day, twice a day, external application, interruption is used altogether more than half a year FA tincture, bad when good during the state of an illness for external application " Beijing opera gold ", Effect is not good, otherwise foot's skin damaged scope expands, and coin size is increased to by nail cover size.Both hands palm newly plays portion's egg size Erythema, warts.Several pieces erythema of finger section nail cover size, warts.Pruritis is aggravated, modern to our hospital.Have a medical check-up：Body temperature 37.2 DEG C, normal face.The no positive sign of cardiopulmonary abdomen.Skin training is checked：At the big skin damaged flush swelling of left foot portion coin, erythema The superficial milky warts of cluster, covers grey scurf；Both hands palm coin great red spot, and intensive milky warts, finger section nail Lid size erythema warts.Cover dirty grey scales of skin that peel off scab.Both arms and lower limb color and luster are normal, and skin elasticity is good, no oedema, without subcutaneous knot Section, no subcutaneous hemorrhage point, no scar, no lump, no spider angioma and liver palms.It is diagnosed as palmar and plantar pustula psoriasis.Give warts Deflorescence, clinical recovery after psoriasis pustulosa medicine, treatment August.

Case two：Mr. Li, female, 23 years old, main cause right hand metacarpus erythema warts, scales of skin that peel off scab was examined with pain more than 2 months.Suffer from Person is because mop is frayed after palm before 2 months, and the erythema of nail cover size is played with the scales of skin that peel off in the centre of the palm, feels mild pain.Originally reason is not given Meeting, PINGYANPING RUANGAO of using by oneself, effect does not show.Otherwise skin damaged expands, and is increased to by nail cover size in coin size, erythema and plays purulence Blister, pain, pruritis are aggravated.It is modern to our hospital.Have a medical check-up：37.2 DEG C of body temperature, normal face.The no positive sign of cardiopulmonary abdomen. Skin training is checked：Right centre of the palm coin great red spot.Several superficial milky warts are dispersed at skin damaged flush swelling, erythema, ash is covered Color scurf.Arm color and luster is normal, and skin elasticity is good, no oedema, no subcutaneous nodule, no subcutaneous hemorrhage point.It is diagnosed as slapping plantar purulence Blister psoriasis pustulosa.Take psoriasis pustulosa medicine March, Schultz-Charlton, clinical recovery.

Case three：Mr. Li, male, 70 years old, the main cause both hands foot warts scales of skin that peel off was chapped 20 years, aggravates May to examine.Patient is in 20 Year half sole plantar erythema warts takes traditional Chinese medicine healing in Xinzhou City institute of traditional Chinese medicine.Recurred before 10 years in Taiyuan and the treatment of Xinzhou Army Hospital, Effect does not show, skin damaged recurrent exerbation.It is to our hospital in August in 2011 20 days.Have a medical check-up：37.2 DEG C of body temperature, face dolorosa.Cardiopulmonary abdomen No positive sign.Skin training is checked：Risen on the basis of both hands palm, the erythema of the large stretch of flush swelling in toes portion, erythema intensive shallow The big pimple of table milky grain grain and dirty taupe scales of skin that peel off scab are with chap, pain.The crisp thickness of finger and toe nail color grey matter is covered firmly, is abound with Thimble sample pitting.Pus point under double thumb first.Both hands underarm and both legs swelling.It is diagnosed as palmar and plantar pustula psoriasis. Take psoriasis pustulosa medicine 13 months.Deflorescence, clinical recovery.

Case four：Xing so-and-so, man, 32 years old, sole erythema warts on the left of main cause, scales of skin that peel off scab, with itch more than 2 months in 2013 January 25 went to a doctor.Patient, without there is the erythema of nail cover size at obvious inducement left foot, covered the grey scales of skin that peel off before 2 months, with itch. It is medical in community clinic, compound fluocinonide tincture external application is given, effect is not good, otherwise foot's skin damaged scope expands, by nail Lid size is increased to and warts is played in coin size, erythema, and pruritis is aggravated.It is modern to our hospital.Have a medical check-up：37.2 DEG C of body temperature, Normal face.The no positive sign of cardiopulmonary abdomen.Skin training is checked：Left foot portion coin great red spot.Group at skin damaged flush swelling, erythema The superficial milky warts of collection, covers grey scurf.Lower limb color and luster is normal, and skin elasticity is good, no oedema, no subcutaneous nodule, nothing Subcutaneous hemorrhage point, no scar, no lump, no spider angioma and liver palms.It is diagnosed as vola pedis psoriasis pustulosa.Give pustule type silver bits Medicine, treats deflorescence, clinical recovery after March.

Case five：Zhang, female is 29 years old, visible several erythema at sole and double lower limb on the left of main cause, warts, erosion, de- Bits, feel that itch is remaining medical on January 25th, 2013 January.There is the dry hide of coin size, color hair in patient at left foot before 1 year It is black, with itch.It is medical in community clinic, give compound fluocinonide tincture twice a day, external application " Beijing opera gold " one day two Secondary, external application is shared more than first quarter moon, bad when good during the state of an illness, effect is not good, otherwise foot's skin damaged scope expands, and erythema is by coin size Increase to palm size and play the big pimple of grain grain, pruritis is aggravated, modern to our hospital.Have a medical check-up：37.2 DEG C of body temperature, normally Face.The no positive sign of cardiopulmonary abdomen.Skin training is checked：At left side sole and double lower limb on the basis of visible several erythema, erythema Play the faint yellow warts of grain grain size, part warts and do and grey scurf is heaved after scab, double lower limb color and luster is normal, and skin elasticity is good, Without oedema, no subcutaneous nodule, no subcutaneous hemorrhage point, no scar, no lump, no spider angioma and liver palms.It is diagnosed as palm plantar warts silver Bits disease.Give deflorescence, clinical recovery after psoriasis pustulosa medicine, treatment August.

Embodiment

Embodiment 1

Removing impurity is weighed, Radix Astragali 28g, Semen Coicis 28g, golden cypress 10g, red sage root 28g, radix scrophulariae 28g, the root bark of tree peony cleaned up After 8g, smilax 28g, cassia twig 8g, frankincense 6g, myrrh 6g, radix bupleuri 8g are well mixed, the active component of Chinese medicine is extracted, is added water pan-fried Boil 3 times, 0.5~1 hour every time, merge 3 decocting liquids, filtering is condensed into the thick paste that 60 DEG C of relative densities are 1.25~1.3, in After 50~60 DEG C of dryings, the medicinal powder of 100 mesh is crushed to, is fitted into capsule, capsule product is made in sterilization.Every weight of this product 1.5 gram.

Application method：Oral medicine of the present invention, one time 3, twice a day, once in the morning and once at night.

Embodiment 2

Removing impurity is weighed, Radix Astragali 30g, Semen Coicis 30g, golden cypress 12g, red sage root 30g, radix scrophulariae 30g, the root bark of tree peony cleaned up After 10g, smilax 30g, cassia twig 10g, frankincense 8g, myrrh 8g, radix bupleuri 10g are well mixed, the active component of Chinese medicine is extracted, is added water Decoct 3 times, 0.5~1 hour every time, merge 3 decocting liquids, filtering is condensed into the thick paste that 60 DEG C of relative densities are 1.25~1.3, After 50~60 DEG C are dried, the medicinal powder of 100 mesh is crushed to, is fitted into capsule, capsule product is made in sterilization.This product every Weigh 1.5 grams.

Application method：Oral medicine of the present invention, one time 3, twice a day, once in the morning and once at night.

Embodiment 3

Removing impurity is weighed, Radix Astragali 32g, Semen Coicis 32g, golden cypress 14g, red sage root 32g, radix scrophulariae 32g, the root bark of tree peony cleaned up After 12g, smilax 32g, cassia twig 12g, frankincense 10g, myrrh 10g, radix bupleuri 12g are well mixed, the active component of Chinese medicine is extracted, plus Decocting boils 3 times, 0.5~1 hour every time, merges 3 decocting liquids, filtering, be condensed into 60 DEG C of relative densities for 1.25~1.3 it is thick Cream, after 50~60 DEG C are dried, is crushed to the medicinal powder of 100 mesh, is fitted into capsule, capsule product is made in sterilization.This product Every 1.5 grams of weight.

Application method：Oral medicine of the present invention, one time 3, twice a day, once in the morning and once at night.

Claims (2)

1. a kind of medicine for treating psoriasis pustulosa, is prepared by the bulk drug of following ratio of weight and number：

Radix Astragali 28-32 Semen Coicis 28-32 golden cypress 10-14 reds sage root 28-32

Radix scrophulariae 28-32 root bark of tree peony 8-12 smilax 28-32 cassia twig 8-12

Frankincense 6-10 myrrh 6-10 radix bupleuri 8-12.

2. treating the medicine of psoriasis pustulosa according to claim 1, the parts by weight of wherein bulk drug are：

The red sage root 30 of 30 Semen Coicis of the Radix Astragali, 30 golden cypress 12

The cassia twig 10 of 30 root bark of tree peony of radix scrophulariae, 10 smilax 30

The radix bupleuri 10 of 8 myrrh of frankincense 8.