CN104001057A

CN104001057A - Medicine for treating heart and kidney imbalanced schizophrenia and preparing method thereof

Info

Publication number: CN104001057A
Application number: CN201410258697.2A
Authority: CN
Inventors: 刘广义
Original assignee: Affiliated Hospital of University of Qingdao
Current assignee: Qiingdao University hospital; Affiliated Hospital of University of Qingdao
Priority date: 2014-06-12
Filing date: 2014-06-12
Publication date: 2014-08-27
Anticipated expiration: 2034-06-12
Also published as: CN104001057B

Abstract

The invention discloses a medicine for treating the heart and kidney imbalanced schizophrenia and a preparing method thereof. The medicine comprises an oral medicine and an external medicine. The oral medicine comprises raw medical materials including gypsum rubrum, cape jasmine, bamboo leaves, coptis chinensis, bistort rhizome, dried radix rehmanniae, radix scrophulariae, cornu bubali, chlorite schist, lumbricus, radix polygoni multiflori preparata, flos rosae rugosae, prunus mume, apiary, radix ranunculi ternate, stiff silkworm, bamboo juice, tabasheer, platycodon grandiflorum, lily, asparagus cochinchinensis, radix polygonati officinalis, sealwort, fructus lycii, glossy privet fruit, mulberry, tortoise shell, folium artemisiae argyi, root of Chinese trichosanthes, spina date seed, platycladi seed, valerian, polygala tenuifolia and acorus gramineus. The external medicine comprises the raw medical materials including angelica sinensis, Chinese prickly ash, polygala tenuifolia, cinnamon, lotus root starch, bighead atractylodes rhizome, aloe and costustoot. The medicine for treating the heart and kidney imbalanced schizophrenia has the advantages that the theory of traditional Chinese medicine is utilized, nourishing yin, suppressing the excessive yang and restoring normal coordination between the heart and the kidney are primary, the medicine has the effects of being quick in effect, definite in therapeutic effect and high in safety performance in treating the heart and kidney imbalanced schizophrenia, no toxic and side effect is produced, and the heart and kidney imbalanced schizophrenia is not prone to relapse.

Description

Be used for the treatment of schizoid medicine of heart kidney disorder type and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, relate in particular to a kind of schizoid medicine of heart kidney disorder type and preparation method thereof that is used for the treatment of.

Background technology

Schizophrenia is one group of major psychosis that the cause of disease is not bright, slow or the subacute onset person between twenty and fifty how, often show as clinically the different syndrome of symptom, relate to the inharmonious of many-sided obstacles such as sensory perception, thinking, emotion and behavior and ergasia.The general Clear consciousness of patient, intelligent normal, but some patients were there will be the infringement of cognitive function in lysis.The course of disease is generally delayed, and is repeatedly and shows effect, increases the weight of or worsen, and decline and mental handicap finally appear in some patients were, but some patients can keep recovery from illness or the state that is almost recovered after treatment.

The clinical syndrome that schizophrenia is comprised of one group of syndrome, it is multifactorial disease.Although at present still not bery clear and definite to the understanding of its cause of disease, the susceptible quality of individual mind and the undesirable element of outside social environment are known together by everybody to the effect of the generation development of disease.Be that susceptible quality or outside undesirable element all may cause by inherent biological factor combined effect the generation of disease, the factor of different its morbidities of patient may be with outbalance in a certain respect.

Schizoid clinical symptoms complexity is various, can relate to the aspects such as sensory perception, thinking, emotion, volitional behavior and cognitive function, and between individuality, symptom is widely different, even if same patient also may show different symptoms in different phase or stadium.(1) sensory perception obstacle, can there is multiple sensory perception obstacle in schizophrenia, the most outstanding sensory perception obstacle is hallucination, comprise auditory hallucination, photis, olfactory hallucination, gustatory hallucination and tactile hallucination etc., and auditory hallucination is the most common.(2) thought disturbance, thought disturbance is schizoid core symptom, mainly comprises form of thinking obstacle and content of thought obstacle.It is main manifestations that form of thinking obstacle be take thinking associative process obstacle, comprises the obstacle of the aspects such as thinking association active procedure (amount, speed and form), thinking association's continuity and logicality.Vain hope is the most common, most important content of thought obstacle.The vain hope the most often occurring has delusion of persecution, delusion of relation, delusion of influence, delusion of jealousy, the delusion of grandeur, non-descent delusion etc.According to estimates, there is delusion of persecution in the schizophrenic up to 80%, delusion of persecution can show as insecurity in various degree, as be monitored, be ostracised, worry to be offerd medicine or murdered etc., under vain hope impact, patient can make defence or aggression, in addition, passive experience is also comparatively outstanding with it at some patients were, on patient's thinking, emotion and behavior generation impact.(3) affective disorder, apathy and emotional responses is inharmonious is the modal emotion symptom of schizophrenic, in addition, the emotion symptoms such as incoordination excitement, irritability, depression and anxiety are also more common.(4) will and behavior disorder, the hypobulia of most of patients even lacks, show as movable minimizing, peel off and stay alone, behavior is passive, lacks due enthusiasm and initiative, and working and learning interest is gone down, be indifferent to future, to clearly not intending in the future, some patient may have some plans and plan, but seldom carries out.(5) cognitive dysfunction, in schizophrenic, the incidence rate of cognitive defect is high, and there is cognitive dysfunction in approximately 85% patient, as cognitive defects such as information processing and selective attention, working memory, short term memory and study, execution functions.Between cognitive defect symptom and other psychotic symptoms, there is certain dependency, as more obvious in the obvious patient's of form of thinking obstacle cognitive defect symptom, the obvious patient's of negative symptoms cognitive defect symptom is more obvious, and cognitive defect may be relevant with the generation of some positive symptom etc.Cognitive defect may betide psychotic symptoms clear before (as prodromal period), or sharply decline along with the appearance of psychotic symptoms, or along with the course of disease extends and progressively decline, tentatively think that Patients with Chronic Schizophrenia is more obvious than the cognitive defect of first episode schizophrenia.

At present, western medical treatment schizophrenia common drug has the long-acting injections such as risperidone, 9-hydroxy-risperidone, western medical treatment schizophrenia is longer the course for the treatment of, and bad should be more, easily produces drug resistance, medicament categories is less, selection limitation, and expensive, patient economy burden is heavier, patient faces society for a long time and psychological problems also can bring stress, even increase the weight of the state of an illness, to patient, bring very big misery.Urgent clinical needs are a kind of can effectively alleviate schizoid medicine, to meet patient's demand.

China's Schizophrenia Treated by TCM is with a long history, has unique advantage, can make up the deficiency of doctor trained in Western medicine; Utilize Traditional Chinese medical theory, great attention to whole idea, be particular about determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs simultaneously, when nursing one's health whole system, recovering refreshing machine, " treating different diseases with the same therapeutic principle ", " treating the same disease with different methods ", under total Therapeutic Principle, for same class disease individualized treatment, targeting is stronger, evident in efficacy, the course for the treatment of is shorter, is difficult for producing drug resistance; Selected natural Chinese medicines material, safety, effective, toxic and side effects is lower, and cost price is low, can carry out market development to meet clinical demand, improves patient's quality of life etc.

The traditional Chinese medical science thinks that schizophrenia belongs to the categories such as motherland's medical science " mad disease ".Mad disease is many because of overaction of the five emotions, or due to congenital heredity, with phlegm-fire blood stasis, inaccessible thinking, the entanglement of god's machine is basic pathogenesis, clinical excited with spirit, manic uneasiness, scolding is scolded and is ruined thing, moving and many anger, even kill a person with a knife as a kind of common multiple psychosis of feature, therefore distinguish that its clinical syndrome is divided into: phlegm-fire is disturbed god, expectorant knot blood stasis, obstruction of the orifices by blood stasis, fire is contained impairment of YIN, the types such as heart kidney imbalance, heart kidney disorder type wherein: mad disease is prolonged for a long time, when time is done, stop, gesture is lighter, talk tactlessly to act recklessly, that exhales can make by oneself, bedroom uneasiness is slept, the tired impatience of sighing, xerostomia dyschezia, red tip of the tongue no fur has breakaway, thready and rapid pulse.

Summary of the invention

Technical problem to be solved by this invention is, a kind of schizoid medicine of heart kidney disorder type and preparation method of being used for the treatment of is provided, the present invention utilizes Traditional Chinese medical theory, great attention to whole idea, be particular about determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs simultaneously, in the whole system of conditioning, when recovering refreshing machine, " treating different diseases with the same therapeutic principle ", " treating the same disease with different methods ", under total Therapeutic Principle, for heart kidney disorder type schizophrenia individualized treatment, with nourishing YIN for attracting YANG, restoring normal coordination between the heart and kidney is main, treatment heart kidney disorder type schizophrenia has rapid-action, determined curative effect, safe, the advantage that has no side effect and be difficult for recurring.

In order to solve the problems of the technologies described above, the invention provides a kind of schizoid medicine of heart kidney disorder type that is used for the treatment of, described medicine comprises endo-medicine and external used medicine, described endo-medicine comprises following raw medicinal material: Mirabilitum crystallina, Fructus Gardeniae, Folium Bambusae, Rhizoma Coptidis, Rhizoma Bistortae, the Radix Rehmanniae, Radix Scrophulariae, Cornu Bubali, Lapis Micae Aureus, Pheretima, Radix Polygoni Multiflori Preparata, Flos Rosae Rugosae, FLOS MUME, Nidus Vespae, Radix Ranunculi Ternati, Bombyx Batryticatus, Succus Bambusae, Concretio Silicea Bambusae, Radix Platycodonis, Bulbus Lilii, Radix Asparagi, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Mori, Carapax Et Plastrum Testudinis, Folium Artemisiae Argyi, Radix Trichosanthis, Semen Ziziphi Spinosae, Semen Platycladi, Rhizoma et radix valerianae, Radix Polygalae and Rhizoma Acori Graminei,

Described external used medicine comprises following raw medicinal material: Radix Angelicae Sinensis, Pericarpium Zanthoxyli, Radix Polygalae, Cortex Cinnamomi, Amylum Nelumbinis Rhizomatis, the Rhizoma Atractylodis Macrocephalae, Aloe and the Radix Aucklandiae.

In described endo-medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 5-9 weight portion, Fructus Gardeniae 10-15 weight portion, Folium Bambusae 10-20 weight portion, Rhizoma Coptidis 15-25 weight portion, Rhizoma Bistortae 10-15 weight portion, Radix Rehmanniae 5-15 weight portion, Radix Scrophulariae 10-15 weight portion, Cornu Bubali 3-9 weight portion, Lapis Micae Aureus 3-10 weight portion, Pheretima 10-15 weight portion, Radix Polygoni Multiflori Preparata 10-20 weight portion, Flos Rosae Rugosae 15-25 weight portion, FLOS MUME 10-15 weight portion, Nidus Vespae 10-25 weight portion, Radix Ranunculi Ternati 5-10 weight portion, Bombyx Batryticatus 15-25 weight portion, Succus Bambusae 10-15 weight portion, Concretio Silicea Bambusae 5-15 weight portion, Radix Platycodonis 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Asparagi 10-20 weight portion, Rhizoma Polygonati Odorati 5-15 weight portion, Rhizoma Polygonati 10-15 weight portion, Fructus Lycii 15-25 weight portion, Fructus Ligustri Lucidi 10-17 weight portion, Fructus Mori 15-25 weight portion, Carapax Et Plastrum Testudinis 3-8 weight portion, Folium Artemisiae Argyi 10-15 weight portion, Radix Trichosanthis 5-10 weight portion, Semen Ziziphi Spinosae 10-25 weight portion, Semen Platycladi 15-25 weight portion, Rhizoma et radix valerianae 9-16 weight portion, Radix Polygalae 10-15 weight portion and Rhizoma Acori Graminei 5-12 weight portion,

In described medicine for external use thing, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 10-20 weight portion, Pericarpium Zanthoxyli 5-10 weight portion, Radix Polygalae 5-12 weight portion, Cortex Cinnamomi 5-8 weight portion, Amylum Nelumbinis Rhizomatis 5-20 weight portion, Rhizoma Atractylodis Macrocephalae 5-9 weight portion, Aloe 10-20 weight portion and Radix Aucklandiae 5-12 weight portion.

In described endo-medicine, the parts by weight of each raw medicinal material are preferably: Mirabilitum crystallina 7 weight portions, Fructus Gardeniae 12 weight portions, Folium Bambusae 15 weight portions, Rhizoma Coptidis 21 weight portions, Rhizoma Bistortae 12 weight portions, the Radix Rehmanniae 7 weight portions, Radix Scrophulariae 12 weight portions, Cornu Bubali 5 weight portions, Lapis Micae Aureus 7 weight portions, Pheretima 12 weight portions, Radix Polygoni Multiflori Preparata 15 weight portions, Flos Rosae Rugosae 22 weight portions, FLOS MUME 12 weight portions, Nidus Vespae 17 weight portions, Radix Ranunculi Ternati 7 weight portions, Bombyx Batryticatus 19 weight portions, Succus Bambusae 12 weight portions, Concretio Silicea Bambusae 11 weight portions, Radix Platycodonis 15 weight portions, Bulbus Lilii 21 weight portions, Radix Asparagi 15 weight portions, Rhizoma Polygonati Odorati 11 weight portions, Rhizoma Polygonati 12 weight portions, Fructus Lycii 21 weight portions, Fructus Ligustri Lucidi 14 weight portions, Fructus Mori 21 weight portions, Carapax Et Plastrum Testudinis 6 weight portions, Folium Artemisiae Argyi 13 weight portions, Radix Trichosanthis 6 weight portions, Semen Ziziphi Spinosae 22 weight portions, Semen Platycladi 21 weight portions, Rhizoma et radix valerianae 12 weight portions, Radix Polygalae 12 weight portions and Rhizoma Acori Graminei 7 weight portions,

In described medicine for external use thing, the parts by weight of each raw medicinal material are preferably: Radix Angelicae Sinensis 15 weight portions, Pericarpium Zanthoxyli 7 weight portions, Radix Polygalae 8 weight portions, Cortex Cinnamomi 6 weight portions, Amylum Nelumbinis Rhizomatis 12 weight portions, the Rhizoma Atractylodis Macrocephalae 7 weight portions, Aloe 15 weight portions and the Radix Aucklandiae 7 weight portions.

In described endo-medicine, the parts by weight of each raw medicinal material can also be preferably: Mirabilitum crystallina 5 weight portions, Fructus Gardeniae 15 weight portions, Folium Bambusae 20 weight portions, Rhizoma Coptidis 25 weight portions, Rhizoma Bistortae 10 weight portions, the Radix Rehmanniae 5 weight portions, Radix Scrophulariae 10 weight portions, Cornu Bubali 3 weight portions, Lapis Micae Aureus 10 weight portions, Pheretima 10 weight portions, Radix Polygoni Multiflori Preparata 10 weight portions, Flos Rosae Rugosae 25 weight portions, FLOS MUME 15 weight portions, Nidus Vespae 25 weight portions, Radix Ranunculi Ternati 5 weight portions, Bombyx Batryticatus 25 weight portions, Succus Bambusae 10 weight portions, Concretio Silicea Bambusae 5 weight portions, Radix Platycodonis 10 weight portions, Bulbus Lilii 25 weight portions, Radix Asparagi 10 weight portions, Rhizoma Polygonati Odorati 15 weight portions, Rhizoma Polygonati 10 weight portions, Fructus Lycii 15 weight portions, Fructus Ligustri Lucidi 10 weight portions, Fructus Mori 15 weight portions, Carapax Et Plastrum Testudinis 3 weight portions, Folium Artemisiae Argyi 15 weight portions, Radix Trichosanthis 10 weight portions, Semen Ziziphi Spinosae 25 weight portions, Semen Platycladi 25 weight portions, Rhizoma et radix valerianae 16 weight portions, Radix Polygalae 10 weight portions and Rhizoma Acori Graminei 5 weight portions,

In described medicine for external use thing, the parts by weight of each raw medicinal material can also be preferably: Radix Angelicae Sinensis 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Radix Polygalae 5 weight portions, Cortex Cinnamomi 8 weight portions, Amylum Nelumbinis Rhizomatis 15 weight portions, the Rhizoma Atractylodis Macrocephalae 9 weight portions, Aloe 20 weight portions and the Radix Aucklandiae 12 weight portions.

In order better to realize foregoing invention object, the invention provides a kind of preparation method that is used for the treatment of the schizoid medicine of heart kidney disorder type, the dosage form of described endo-medicine is oral solutions, its preparation method comprises the following steps:

The first step, Fructus Gardeniae, Folium Bambusae, Pheretima, Radix Polygoni Multiflori Preparata and Flos Rosae Rugosae are mixed, add with respect to 3 times～5 times, mixture and measure the ethanol that determining alcohols are 55%～65%, reflux, extract, 2～4 times, each 2 hours～3 hours, filters, filtrate merges, reclaim ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.30～1.32, standby;

Second step, is mixed in proportion surplus stock medical material, adds with respect to 3～5 times of water gagings of mixture, boils 2～4 hours, filters, and is concentrated into the mastic that 70 ℃ of relative densities are 1.27～1.29;

The 3rd step, the described mastic that the first step, second step are obtained mixes, and 55 ℃～65 ℃ reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, obtain containing alcohol mastic, and described is 65%～70% containing alcohol mastic containing alcohol amount; By described, containing alcohol mastic, carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis mastic, carries out successively heat treated, filtration treatment, dilution process, obtains semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1～0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001～0.002; The time of described heat treated is 20～40 minutes, and temperature is 100 ℃～110 ℃;

The 6th step, the more described semi-finished product of the 5th step acquisition are carried out to filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

The dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 85%～95%, and reflux 1～3 hour is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～2 times of described medicinal residues quality is 85%～95% again, and reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

The dosage form of described external used medicine is navel patch, and its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, is ground into 40 order～60 object powder, adds the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 85～95%, and reflux 1～3 hour is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～2 times of described medicinal residues quality is 85～95% again, and reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract, and is ground into 100 order～200 object powder;

Second step, dissolves stearic acid heating, and remaining on temperature is 70 ℃～80 ℃, obtains stearic acid liquid; In addition, the part by weight of potassium hydroxide, glycerol, ethyl hydroxybenzoate and distilled water being pressed to 5:500:1:600 mixes, and heating, maintains the temperature at 70 ℃～80 ℃, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor according to the part by weight of 1:100, stir coolingly simultaneously, obtain substrate;

The 3rd step, the Chinese medicinal powder that the substrate obtaining to second step adds the first step of equivalent to obtain, and being constantly ground to evenly, heating obtains sticky paste, granulates, dry after, obtain pill, coordinate medical proof fabric or special-purpose navel paster that pill is attached to umbilicus place.

The invention has the beneficial effects as follows: the present invention utilizes Traditional Chinese medical theory, great attention to whole idea, be particular about determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs simultaneously, when nursing one's health whole system, recovering refreshing machine, " treating different diseases with the same therapeutic principle ", " treating the same disease with different methods ", under total Therapeutic Principle, for heart kidney disorder type schizophrenia individualized treatment, take nourishing YIN for attracting YANG, restoring normal coordination between the heart and kidney as main, and that treatment heart kidney disorder type schizophrenia has is rapid-action, determined curative effect, safe, the advantage that has no side effect and be difficult for recurring.

The specific embodiment

Umbilicus, Chinese medicine acupoint claims again " Shenque ".It is connected with the human body twelve regular channels, the vital organs of the human body communicate, and the traditional Chinese medical science thinks, umbilicus is heart kidney traffic " door ".So-called umbilicus is treated (Hilum therapy), exactly medicine is directly applied ointment or plaster or treats the umbilical part in patient by methods such as moxa-moxibustion, hot compresses, excites QI of channels and collaterals, promoting flow of QI and blood, and conditioning viscera, in order to a kind of external therapy of prevention and treatment disease.Umbilicus (being SHENQUE acupoint) is in abdominal part central authorities, be of human body important through cave, have very close relationship with meridians, the traditional Chinese medical science be referred to as twelve channels and collaterals root, breathings; The Shenque acromphalus of living in caves, it is (the sea that conception vessel is warp, an important acupuncture point of conception vessel, therefore stimulate this cave to there is regulating action to the vital organs of the human body), again because the skin of umbilical part is thinner, nerve and blood vessel are abundanter, the internal organs that it is supported and blood vessel comprise mould barrier film, liver, spleen, stomach, adrenal gland, ureter, bladder, so umbilical part sees through and the contacting of the vital organs of the human body, the twelve regular channels, eight extra-channel, and have more intense absorption and conducting power.Moxibustion umbilicus can be controlled and faint, goes into a coma, suffers a shock clinically, therefore have excited brain, heart tonifying, the microcirculatory effect of improvement; Medicine applies umbilicus can control sweating due to debility, and nervous vomiting, therefore there is the effect of adjusting autonomic nervous dysfunction; Moxibustion Shenque can be controlled sexual impotence, infertile, therefore there is the function of endocrine regulation disorder; Cupping in SHENQUE acupoint, can control urticaria and allergic asthma, can act on immune system, suppress anaphylaxis.Chinese medicine thinks, internal injury caused by excess of seven emotions, eating and drinking without temperance and congenital heredity are primary disease main pathogenics, and the inaccessible heart and brain of phlegm-fire blood stasis, imbalance of YIN and YANG, body and the spirit is out of control is its pathogenesis place., at heart and brain, there is substantial connection its sick position with liver and gall spleen.Its characteristic of disease is from the beginning of being main mainly with excess syndrome, as the heart disturbed by phlegm-fire; The blood that intimately burns of continuing is the stasis of blood, and refining liquid is expectorant and common expectorant knot blood stasis, obstruction of the orifices by blood stasis; With the passing of time and many deficiency in origin and excess in superficiality, as fire is contained yin-damaging and Qi consuming, disarmony between the heart and kidney etc.Treatment is to fall (letting out) fire, eliminating phlegm, to invigorate blood circulation, have one's ideas straightened out to take stopgap measures, and regulating YIN and YANG, recovers refreshing machine to effect a permanent cure, and is its basic principle, and meanwhile, intensive care, prevents that unexpected is also very important principle.Medicine provided by the invention comprises endo-medicine and external used medicine navel patch, and the oral administration and externally treatment heart kidney disorder type schizophrenia effect that combines is remarkable.

The invention provides a kind of schizoid medicine of heart kidney disorder type that is used for the treatment of, described medicine comprises endo-medicine and external used medicine, and described endo-medicine comprises following raw medicinal material: Mirabilitum crystallina, Fructus Gardeniae, Folium Bambusae, Rhizoma Coptidis, Rhizoma Bistortae, the Radix Rehmanniae, Radix Scrophulariae, Cornu Bubali, Lapis Micae Aureus, Pheretima, Radix Polygoni Multiflori Preparata, Flos Rosae Rugosae, FLOS MUME, Nidus Vespae, Radix Ranunculi Ternati, Bombyx Batryticatus, Succus Bambusae, Concretio Silicea Bambusae, Radix Platycodonis, Bulbus Lilii, Radix Asparagi, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Mori, Carapax Et Plastrum Testudinis, Folium Artemisiae Argyi, Radix Trichosanthis, Semen Ziziphi Spinosae, Semen Platycladi, Rhizoma et radix valerianae, Radix Polygalae and Rhizoma Acori Graminei; Described external used medicine comprises following raw medicinal material: Radix Angelicae Sinensis, Pericarpium Zanthoxyli, Radix Polygalae, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Aloe and the Radix Aucklandiae.Wherein, Mirabilitum crystallina, Fructus Gardeniae, Folium Bambusae, Rhizoma Coptidis, Rhizoma Bistortae clearing away heat-fire; The Radix Rehmanniae, Radix Scrophulariae, Cornu Bubali nourishing YIN and clearing away heat; Lapis Micae Aureus, Pheretima, Radix Polygoni Multiflori Preparata, Flos Rosae Rugosae, FLOS MUME, the Rhizoma Atractylodis Macrocephalae, Nidus Vespae, Pericarpium Zanthoxyli, Radix Ranunculi Ternati, Bombyx Batryticatus, Succus Bambusae, Concretio Silicea Bambusae, Radix Platycodonis inducing resuscitation and resolving phlegm, heat clearing away arresting convulsion; Radix Angelicae Sinensis, Aloe, Radix Aucklandiae Bulbus Lilii, Radix Asparagi, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Mori, Amylum Nelumbinis Rhizomatis, Carapax Et Plastrum Testudinis tonifying kidney and nourishing yin, nourishing YIN and benefiting blood; Radix Trichosanthis, Folium Artemisiae Argyi, Semen Ziziphi Spinosae, Semen Platycladi, Rhizoma et radix valerianae, Radix Polygalae, Rhizoma Acori Graminei is relieving convulsion, tranquilizing by nourishing the heart.

Wherein, in above-mentioned endo-medicine, the pharmacology of each raw medicinal material is as follows:

Mirabilitum crystallina: pungent, salty, cold; GUIXIN, stomach, kidney channel.< < Mingyi Bielu > >: " Mirabilitum crystallina, color is as Muscovitum, and removable person is good, and salt essence is also.You Zhongshui county, raw Radix Dichroae mountain valley and Handan." < < Compendium of Materia Medica > >: " and control white urine, interior numbness, removing heat from blood pathogenic fire reducing, only has a toothache, and hard tooth is bright." row calentura while curing mainly, high fever excessive thirst, laryngopharynx swelling and pain, edema, urine retention, aphtha of the mouth and tongue, carbuncle, erysipelas, scalds.Mirabilitum crystallina treating disorders in five ZANG-organs six internal organs are long-pending ripe, day row seasonal epidemic pathogens plague fever, so that stuffy sensation with restlessness quenches one's thirst, curing the wound cold going mad, or abandon clothing and run.Control the wind heat heart hot-tempered, xerostomia raving, from head to foot high fever and in all poison.

Fructus Gardeniae: bitter, cold, nontoxic; Enter heart channel, Liver Channel, lung meridian, stomach warp, tri-jiao channel.< < Sheng Nong's herbal classic > >: " main five interior pathogens, pathogenic heat in the stomach gas, flushed complexion wine acne vulgaris nose, the red impetigo infections of tuberculoid leprosy." < < Mingyi Bielu > >: " Great Cold, nontoxic.Cure mainly the hot swelling pain of order, the large heat of breast heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, and headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprains and swells and ache.This product bitter cold is fallen clearly, can rush down clearly three warmers pathogenic fire, eliminating heart-fire and relieving restlessness, for controlling the key medicine that calentura is vexed, restlessness is not peaceful.The effect that has sharp clearly part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels dampness-heat in the liver and gallbladder, the jaundice of available treating the liver gallbladder retention and fumigation of damp-heat inside the body, oliguria with reddish urine person.The hypotensive activity position of Fructus Gardeniae, at maincenter, is mainly to have strengthened due to medulla oblongata parasympathetic maincenter tensity.

Folium Bambusae: nature and flavor, sweet, be slightly cold.< < Compendium of Materia Medica > >: " go dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, children's's pox poison, outer disease is vicious." effect clearing heat and relieving fidgetness, inducing diuresis for treating stranguria syndrome.< < vegetation is square > > just: " expectorant is quenched the thirst.Control dysphoria with smothery sensation, cough with asthma, spits blood, the sound of vomiting of vomitting, pediatric epilepsy scared." for calentura excessive thirst, heart stomach-fire is contained.Folium Bambosae extract is a kind of bioflavonoid health care nutrient newly developed, has good antiradical activities and conclusive quasi-SOD activity; To the blocking ability of nitrosation reaction, can compare favourably with VC; Effect and the pollen of defying age, anti-stress and resisting fatigue are suitable; Blood fat reducing and cholesterolemia, antioxidative effect are identical with Folium Ginkgo extract; Antibacterial, antiinflammatory is similar to tea polyphenols with antivirus action; The effect victory Succus Bambusae one of relieving cough and expelling phlegm, heat-clearing and toxic substances removing is raised; And there is significant immunological enhancement, can improve the resistance of human body to poor environment and disease: also there is good hydrothermal stability, antioxidative stabilizer and unique Folium Bambusae delicate fragrance., containing any harmful components and antinutritional factor, without toxicity, side effect, not a kind of very good pure natural health-care.

Rhizoma Coptidis: hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.< < Yaoxing Fu > >: " bitter in the mouth, flat, gas is cold, nontoxic.Sink also, the moon also.It is with having four: eliminating heart-fire, the shape of the epigastric fullness that disappears; Main intestinal Bleach is red except what mix in intestinal; Control order disease and break out suitable use, treat skin infection head and the tail all same." function heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing pathogen in the heart stomach, has the disappear merit of painful abdominal mass of preventing or arresting vomiting concurrently, can be used for treating the dysphoria and insomnia of heart-fire due to prosperous, and heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.For cold and heat, tie mutually damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Rhizoma Bistortae: hardship, cool; Return lung, liver, large intestine channel.The modern Practical Chinese medicinal > of < < the >: " bloody dysentery of controlling for oral administration; Rinsing the mouth is made the astringent of stomatitis; Hemorrhoid and abscess are controlled in external." < < Chinese medicinal herbal > >: " heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Control calentura infantile convulsion, tetany, tetanus, carbuncle scrofula, snake bite and insect sting." heat clearing away is relieving convulsion, the wet detumescence of reason.Control that calentura is frightened jerks, tetanus, bloody dysentery, carbuncle, scrofula.Rhizoma Bistortae is oozed Rhizoma Bistortae clean No. 1 of the hemostasis that liquid and gelatin etc. make of filtering, and for dog and the various hemostasis experiments of sheep (femoral artery cuts off, liver clip, splenectomy etc. are hemorrhage), all has certain haemostatic effect.In vitro staphylococcus aureus, bacillus pyocyaneus, bacillus subtilis, escherichia coli etc. are all had to antibacterial action.

The Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel.< < Sheng Nong's herbal classic > >: " sweet in the mouth, cold.Cure mainly folding and fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fills out bone marrow, longue meat.Make soup and gather except cold and heat, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in treating the diseases such as hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.By the Radix Rehmanniae being take to Fructus Amomi, wine, Pericarpium Citri Reticulatae, it is adjuvant, repeatedly steam and shine to color blackening, quality softness is for Radix Rehmanniae Preparata, and the LIUWEI DIHUANG WAN that has Radix Rehmanniae Preparata to make, be exactly famous the kidney invigorating good medicine, the clinical treatment that is also usually used in the diseases such as chronic nephritis, hypertension, neurasthenia, pulmonary tuberculosis.

Radix Scrophulariae: sweet, cold; GUIXIN, liver, kidney channel.< < Sheng Nong's herbal classic > >: " sweet in the mouth, cold.Cure mainly folding and fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fills out bone marrow, longue meat.Make soup and gather except cold and heat, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in treating the diseases such as hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.By the Radix Rehmanniae being take to Fructus Amomi, wine, Pericarpium Citri Reticulatae, it is adjuvant, repeatedly steam and shine to color blackening, quality softness is for Radix Rehmanniae Preparata, and the LIUWEI DIHUANG WAN that has Radix Rehmanniae Preparata to make, be exactly famous the kidney invigorating good medicine, the clinical treatment that is also usually used in the diseases such as chronic nephritis, hypertension, neurasthenia, pulmonary tuberculosis.

Cornu Bubali: bitter salty, cold.Enter the heart, liver, spleen, stomach four warps.< < Luchuan book on Chinese herbal medicine > >: " removing pathogenic heat from blood and toxic substance from the body, only nosebleed.Control calentura stupor, numb pox macule, spits blood, epistaxis, heat in blood, dark coloured urine." heat clearing away, removing heat from blood, removing toxic substances.Control calentura headache, high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.The aqueous solution of Cornu Bovis seu Bubali decoct or ether extract (hereinafter to be referred as extract) all has potentiation to Isolated Toad Heart and extrasomatic rabbit heart, and can make it to stop at systole, this kind of cardiotonic is not due to the contained inorganic salt of Cornu Bovis seu Bubali, because cardiotonic appears in extract too.Cornu Bubali has the effect in obvious shortening bleeding time, and has the effect of blood pressure lowering.Its LVFS is 14.5%.Cornu Bubali ether or 95% ethanol extract, all have obvious sedation to rat.

Lapis Micae Aureus: salty, flat; Enter liver, lung, stomach warp.< < book on Chinese herbal medicine question and answer > >: " Lapis Micae Aureus, must forge with Sal Nitri, and property begins to send out, and is to fall expectorant, does not forge stone matter and does not change, and the property of medicine is not sent out, and poison is not loose again, therefore must be with forging." Miao Xiyong: " Lapis Micae Aureus is reported in stone just violent property, and body weight and falling can disappear that all gather expectorant knot, and removing food stagnancy is stagnant, and pendant sputum is really key medicine." pendant expectorant, help digestion, the therapeutic method to keep the adverse QI flowing downwards, suppressing the hyperactive liver.Control the pertinacious phlegm hypochondriac lump, dyspepsia lump in the abdomen, demented infantile convulsion, cough dyspnea with rapid respiration, stops up on sputum.Lapis Micae Aureus matter heavily falls and falls, and salty in the mouth softening the hard mass kind is controlled the solid disease of pertinacious phlegm glue, often joins Lignum Aquilariae Resinatum, Radix Scutellariae, Radix Et Rhizoma Rhei and is equal to use.Control the convulsion with spasms that heat-phlegm is jammed and causes, take and forge Lapis Micae Aureus as end, with Herba Menthae juice and whitish honey, be taken after mixing with liquid.If accumulation of phlegm Jing Epilepsy, constipation person, available Mengshi Guntan Wan is to calm the frightened by expectorant pathogenic fire reducing; Clinical in Zhi epilepsy and schizophrenia, effective to controlling outbreak and slowing down mania shape.

Pheretima: heat clearing away, spasmolytic, diuresis, removing toxic substances.For calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia Pheretima dish.External is coated with the diseases such as erysipelas, dermatitis rhus.Lumbar injection earthworm injection 10g/kg, surveys the pre-always cerebral infarction that artery ligation causes to mongolian gerbils one and has certain preventive effect in advance, can alleviate the symptom of cerebral infarction; Mice only gavages Pheretima extract l1mg/ every day, and continuous 58d, to the sarcoma S180 transplanting.Have obvious inhibitory action, not only tumor body obviously reduces, and can extend the life cycle of mice.

Radix Polygoni Multiflori Preparata: bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Function cures mainly: removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.

Flos Rosae Rugosae: warm in nature, sweet and slightly bitter taste, returns liver spleen channel.< < A Supplement to the Compendium of Materia Medica > >: " and blood, promoting the circulation of blood, regulates the flow of vital energy.Control migratory arthralgia." < < book on Chinese herbal medicine new > > again: " the strongly fragrant gas of soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing.Control cold type of pain in abdomen, gastral cavilty is long-pending cold, and holding concurrently can removing blood stasis." promoting the circulation of QI, promoting the circulation of blood, control migratory arthralgia, loose tired pain relieving.Flos Rosae Rugosae and Herb have convergence, can be used for woman in menstrual period too much, and leucorrhea with red and white discharge and enteritis, dysentery, the red half of intestinal are hemorrhage etc.Regulate the flow of vital energy resolving depression and blood dissipating blood stasis.Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, new lingering pathogenic wind numbness, the spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.In Flos Rosae Rugosae, contain 300 various chemical components, as fragrant alcohol, aldehyde, fatty acid, phenol with containing oil and the fat of essence, often eat in Flos Rosae Rugosae goods with the easing the affected liver stomach of waking up, have a respite and invigorate blood circulation, looks improving and the skin nourishing, makes us refreshing refreshing.

FLOS MUME: sour and astringent, flat.Return liver, stomach, lung meridian.< < A Supplement to the Compendium of Materia Medica > >: " < < all sorts of flowers mirror > >: powder for improving appetite is evil; the food of cooking congee; help the gas of sun clearly to rise; distillation point tea; promoting the production of body fluid to quench thirst, expelling summer-heat is washed tired." soothing liver-QI, stomach function regulating, reduces phlegm.Control globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizziness, scrofula.Stomachache due to hyperactive liver-QI attacking the stomach.The circulation of qi promoting of this product fragrance enters liver stomach, and energy dispersing the stagnated live-QI to relieve the stagnation of QI, is amusing, regulating the flow of Qi and the middle Jiao.

Nidus Vespae: sweet, flat.Return stomach warp.Function cures mainly: dispels the wind, and merit poison, parasite killing, pain relieving.For toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot.

Radix Ranunculi Ternati: sweet, pungent, tepor.Return liver, lung meridian.Dissipating phlegm and resolving masses, removing toxic substances and promoting subsidence of swelling.Cure mainly scrofula sucutaneous nodule, furuncle, worm venom, migraine, malaria, toothache.Pulmonary tuberculosis, tuberculous lymphadenitis, lymphadenitis, pharyngolaryngitis.For the mechanism of Radix Ranunculi Ternati anti-tubercle bacillus, Zhan Li etc. adopt reverse transcriptional PCR sxemiquantitative (QC-RT-PCR) method and PCR method, the little Herba Ranunculi Japonici lactone of Radix Ranunculi Ternati effective ingredient (Tern) have been carried out to the research of anti-tubercle bacillus molecular immunology mechanism.

Bombyx Batryticatus: salty, pungent, flat; Return liver, lung, stomach warp.< < Sheng Nong's herbal classic > >: " main pediatric epilepsy scared, night cry, go three worms, goes out black, makes us complexion good, and the cloudy infections of man is sick." < < Compendium of Materia Medica > >: " erysipelas is had an itch for loose wind-phlegm tuberculosis, scrofula, wind syndrome of head, wind worm toothache, skin wind skin ulcer ... all incised wounds, the furuncle wind hemorrhoid that swell." Bombyx Batryticatus alcohol water-leach liquor all has hypnosis, anticonvulsant action to mice, rabbit; Its extracting solution in vivo, all have a stronger anticoagulation outward; Bombyx Batryticatus powder has good hypoglycemic activity; In vitro tests, has slight bacteriostasis to staphylococcus aureus, bacillus pyocyaneus, and the external breathing that suppresses human hepatoma cell of its alcohol extract, can be used for the treatment of rectum tumor type polyp.

Succus Bambusae: sweetness and bitterness, cold; Enter the heart, stomach warp.< < Bencao Beiyao > >: " pathogenic wind expelling pathogenic fire reducing, moisturizes row expectorant, the tonifying YIN that nourishes blood, sharp key tomorrow.Control apoplexy locked mouth, the large heat of expectorant fan, puerperal tetanus is demented, and unhappiness is quenched one's thirst, spontaneous sweating due to deficientcy of blood.Liver-fire, falls in " < < book on Chinese herbal medicine is new > > again: " clearing away heart-fire, reduces phlegm and quenches the thirst, and antipyretic relieving restlessness, controls toothache, bright eyes." fire of the lung stomach that clears away heart-fire has that eliminating phlegm is moisturized, the effect of arresting convulsion.Be mainly used in controlling middle wind-phlegm fan, lung-heat expectorant is stopped up, infantile convulsion, epilepsy, high fever excessive thirst, restlessness during pregnancy, tetanus.

Concretio Silicea Bambusae: sweet, cold; Enter the heart, liver, lung meridian.< < Japan hanako materia medica > >: " control middle wind-phlegm and stop up, acute aphasia in silence, convulsive seizure induced by terror in children and epilepsy expectorant." < < Kaibao Bencao > >: " main infantile convulsion sky hangs, and relieving palpitation improving eyesight, goes all wind heat, treats incised wound hemostasis, nourishes the five internal organs." function clear heat and eliminate phlegm, cool heart arresting convulsion.Cure mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.Phlegm-heat cough.Fungus Zhuhuang water decoction extract 2-3.1g/kg subcutaneous injection, has good analgesic activity to mice acetic acid zest pain.Fungus Zhuhuang polysaccharide SB1 and SB2, through pharmacology preliminary test, have certain curative effect to hepatitis, can show prolongation blood plasma recalcification time, and in blood coagulation tests, this medicine can extend clotting time, may extend relevant with recalcification time.

Radix Platycodonis: bitter in the mouth, pungent, property is flat.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, the effect that fills blood, mend five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.< < herbal classic > > says: " main chest and hypochondrium is as lancination, abdominal distention, borborygmus are faint, the gas of throbbing with fear in terror ".< < Japan hanako materia medica > > says: " lower all gas, stop cramp caused by acute vomiting and diarrhea, and trusted subordinate's distending pain is mended five kinds of over strain; foster the spirit of nobility, evil removing is warded off temperature, tonify deficiency expectorant; broken lump in the abdomen, and the evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat ".Modern pharmacological research shows, Radix Platycodonis has and eliminates the phlegm and antitussive effect; Hypoglycemic activity; Suppress gastric secretion and antiulcer action; Antiinflammatory action; Calmness, analgesia and refrigeration function.

Bulbus Lilii: Bulbus Lilii is except containing protein 21.29%, fat 12.43%, reducing sugar 11.47%, starch 1.61%, and calcium, phosphorus, ferrum, every hectogram are containing outside the nutrients such as 1.443 milligrams of vitamin Bs, 21.2 milligrams of vitamin Cs, also contain some special nutritional labelings, as multiple alkaloids such as colchicine.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also multiple Seasonal diseases dry in autumn and that cause is had to certain preventive and therapeutic effect.In the traditional Chinese medical science, say that fresh Bulbus Lilii has tranquilizing by nourishing the heart, the effect of nourishing the lung to arrest cough, is highly profitable to weakling after being ill.

Radix Asparagi: cold in nature, sweet and slightly bitter taste; Enter liver, lung, kidney channel.< < property of medicine opinion > >: " main lung qi cough with dyspnea, pants short anxious, heat extraction, and logical kidney qi, treats the raw carbuncle vomiting pus of consumptive lung disease, controls scabies humida, only quench one's thirst, the apoplexy of reducing phlegm and internal heat, for a long time clothes." < < Japan hanako materia medica > >: " relieving palpitation, moistening five ZANG-organs, beneficial skin, improving healthy complexion, mend five kinds of strain and seven kinds of impairment, control lung qi and cough, expectorant, migratory arthralgia pyretic toxicity, urticaria, unhappy haematemesis." to general optimum mammary neoplasms, especially breast lobule hyperplasia, no matter lump is big or small, prove effective rapidly, great majority can obtain healing.Have and calm the nerves, nourish heart, lung moistening, tonification, nourishing kidney, the curative effects such as blood pressure lowering and loosening bowel to relieve constipation.Decoct in vitro tests all has bacteriostasis in various degree to anthrax bacillus, A type and beta hemolytic streptococcus, diphtheria corynebacterium, diphtheroid, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, Staphylococcus albus and bacillus subtilis.

Rhizoma Polygonati Odorati: sweet in the mouth, property is flat; Attach to the lung and stomach meridians.< < property of medicine opinion > >: " disease cold and heat when main, interior tonifying for the deficiency, removes asthenia exopathogenic heat, and headache is uneasy, adds and good with it." < < Japan hanako materia medica > >: " and except unhappy, quench the thirst, profit cardiopulmonary, mend five kinds of strain and seven kinds of impairment, deficient, waist foot pain, and it row is fanatical." < < Compendium of Materia Medica > >: " and main air temperature spontaneous perspiration is scorching hot, and malaria with general debility cold and heat, and taste void is weary, man's frequent micturition, and consumption of essence, all are deficient." Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moisten, and is the good medicine of YIN nourishing and the production of body fluid promoting simply.. the steroid glycoside that Rhizoma Polygonati Odorati contains, similar to myocardium effect and Herba Convallariae preparation.Rhizoma Polygonati Odorati glycocide has cardiotonic to isolated frog heart, and the effect of Rhizoma Polygonati Odorati decoct and Rhizoma Polygonati Odorati glycocide are similar.Rhizoma Polygonati Odorati extractum lumbar injection, can strengthen burned mice Peritoneal macrophages Phagocytosis, improves Hemolysin level, improves the breeder reaction of splenocyte to ConA.These product have the laboratory animal of promotion antibody and generate, improve phagocytic percentage and the phagocytic index of macrophage, promote interferon synthetic, suppress growth of bacillus tubercle, blood sugar lowering, blood fat reducing, alleviates atherosclerotic plaque and forms, and makes peripheral blood vessel and coronary dilation, extend hypoxia endurance time, heart tonifying, antioxidation, the anti-ageing effect of waiting for a long time.Also has the effect of similar adrenocortical hormone sample.

Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, there is the yin nourishing of fostering the spirit of nobility, spleen invigorating lung moistening, the effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, dry cough expectorant is few, the polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, the quenching one's thirst of yin asthenia generating intrinsic heat, the cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.In vitro tests shows, Rhizoma Polygonati water extraction fluid (1: 320) has inhibitory action to Bacillus typhi, staphylococcus aureus, acid-fast bacilli, and 2% Rhizoma Polygonati has inhibitory action in various degree to common pathomycete in sabouraud culture medium.Rabbit gavage Rhizoma Polygonati extractum, its blood sugar content increases gradually, then reduces.Blood glucose that Rhizoma Polygonati extractum causes epinephrine is too high is remarkable inhibitory action.

Fructus Lycii: sweet, flat.Enter liver, kidney, lung meridian.< < Treatise on Dietetic Therapy > >: " hard muscle is resistance to old, and except wind, tonification muscles and bones, the beneficial people of energy, removes asthenia." control hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.The effects such as lycium barbarum polysaccharide has Promote immunity, defying age, antitumor, removing free radical, resisting fatigue, radioprotective, protects the liver, reproductive function protection and improvement.Carotene is the main active of wolfberry pigment, has antioxidation and as the important physiological functions such as synthetic precursor of vitamin A.Mouse gavaging Fructus Lycii water extract or intramuscular injection alcohol extract and lycium barbarum polysaccharide, the phagocytic function of the macrophage that is improved, strengthens the effect of serum lysozyme, and in raising serum, anti-sheep red blood cell (SRBC) antibody tires.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, enter liver, kidney channel, there is strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, is mainly used in treating hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Control poor vision, often join Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Lycii is equal to use, controls early whitening of beard and hair, often joins Herba Ecliptae, and Fructus Mori are equal to use, control fever due to yin deficiency, often join Cortex Lycii, and Radix Rehmanniae is equal to use.< < Compendium of Materia Medica > > records: " it is verdant that this wood is insulted winter, the behaviour who has chastity to keep, thus with Fructus Ligustri Lucidi shape it ... when near to put wax insect, therefore be commonly called as wax tree." Fructus Ligustri Lucidi can promote leukocyte, strengthens the effect of immunologic function, and staphylococcus aureus, dysentery bacterium are had to stronger inhibitory action.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, has heart tonifying, diuresis and hepatoprotective effect, can make the leukopenia quantity causing because of chemotherapy raise, and staphylococcus aureus, escherichia coli are had to inhibitory action.

Fructus Mori: bitter in the mouth, sweet, cold in nature; Return lung, Liver Channel.< < Bencao Shiyi > >: " main abdominal pain due to acute vomiting and diarrhea is told down, and take it with dense the boiling of dry person the eleventh month of the lunar calendar.Smooth file, takes as red sugar in large still, removes old wind and stagnated blood." < < Japan hanako materia medica > >: " sharp the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction; Except wind is perspired bitterly, and flutter damage blood stasis, and Zheng Hou An; Snakeworm Scolopendra stings, and salt Norway applies." Folium Mori energy dispelling wind and heat pathogens, the heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting; Fructus Mori energy nourishing YIN and benefiting blood, tonify deficiency is moisturized; The eliminating pathogen from the lung for relieving asthma of Cortex Mori energy, inducing diuresis to remove edema; Ramulus Mori energy dredge the meridian passage, eliminating impediment pain relieving; And the ash that mulberry burns till is Pulvis Lignum Mori, also can be used for the treatment of conjunctival congestion and swelling pain, optic atrohic blindness, body face edema, sitting and lying must not, the disease such as vitiligo, seborrheic dermatitis of the scalp, leprosy.In Fructus Mori, contain trypsininhibitory substance, cause the digestive enzyme in intestinal can not destroy C type generation bacillus capsulatus B toxin, and the enteritis that causes bleeding.Fructus Mori fatty acids, excessive eating can produce irritation to digestive tract.

Carapax Et Plastrum Testudinis: salty, sweet, be slightly cold; Return liver, kidney, heart channel.< < Compendium of Materia Medica > >: " reinforcing the heart, the kidney invigorating, enrich blood, all with yin nourishing also ... see Carapax Et Plastrum Testudinis and lead all diseases, a little less than all belonging to deficiency of YIN blood." nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, the reinforcing the heart of nourishing blood.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.During decoct high concentration, Isolated Rat Uterus is had to certain contraction; Bacillus tuberculosis is had to inhibitory action; The continuous gavage of Carapax Et Plastrum Testudinis decoct has impact to rat hormonal system in 6 days.Carapax Et Plastrum Testudinis can improve animal " deficiency of YIN " card pathology animal functional status, makes it to recover normal; Can strengthen immunologic function; The effect with two-ways regulation DNA synthetic ratio; To in vitro and all have excitation in body uterus; Have antipyretic, enrich blood, sedation; Still there is anticoagulation, increase coronary flow and improve the effects such as hypoxia-bearing capability; Colla Plastri Testudinis has the effect of certain lifting leukocyte count.

Folium Artemisiae Argyi: pungent, bitter, temperature.Return liver,spleen,kidney warp.Function cures mainly: dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spits blood, epistaxis, metrorrhagia warp is many, gestation hemorrhage; External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficiency and coldness.

Radix Trichosanthis: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Function cures mainly: clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.

Semen Ziziphi Spinosae: sweet, sour, property is flat.GUIXIN warp, spleen channel, Liver Channel, gallbladder meridian.< < Sheng Nong's herbal classic > >: " invigorating middle warmer the liver benefiting, hard muscles and bones are helped cloudy gas, and all the merit of Semen Ziziphi Spinosae also." < < herbal classic > >: " main trusted subordinate's cold and heat, pathogens agglomerating gas is poly-, painful limbs, arthralgia chiefly caused by damp pathogen." < < do not record > >: " and main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, hard muscles and bones, helps cloudy gas, makes us fertile strong." < < property of medicine opinion > >: " main muscles and bones wind is fried end and is taken it as soup.Function " nourishing the liver, mind calming, calms the nerves, arresting sweating.There are calmness, hypnosis, analgesia, anticonvulsant action; There is certain hypotensive effect; There is to excitation in uterus.For deficiency of YIN-blood, severe palpitation, insomnia forgetfulness; The empty hyperhidrosis of body.To rat, oral or lumbar injection all behaves with composure and somnolence Semen Ziziphi Spinosae decoct, and no matter daytime or night, Semen Ziziphi Spinosae all can show above-mentioned effect.

Semen Platycladi: sweet, flat.GUIXIN, kidney, large intestine channel.< < Sheng Nong's herbal classic > >: " cypress is real, and sweet in the mouth is flat, main palpitation with fear, and settling five organs, QI invigorating, except rheumatism numbness, clothes make us moist, beauty, normal hearing and eyesight for a long time." < < Compendium of Materia Medica > >: " and the gas that nourishes heart, profit kidney is dry, and peace soul is determined soul, and Fructus Alpiniae Oxyphyllae is allayed excitement." " Semen Platycladi is flat and cold not dry, sweet in the mouth and mending, Xin Erneng profit, its gas delicate fragrance, heart kidney thoroughly, strengthening the spleen stomach." tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, the diseases such as dryness of the intestine constipation.Semen Platycladi folk prescription injection can make the S sleep sound sleep phase of cat obviously extend, and has the effect of regaining one's strength significantly.

Rhizoma et radix valerianae: pungent, sweet, warm; GUIXIN, Liver Channel.< < Traditional Chinese Medicine in Sichuan will > >: " control cranial nerve and the heart, stomach is weak, chronic off one's dot and urine collapse." control irritability, a little less than stomach, lumbago, menoxenia, traumatic injury.Apply its effect of calming the nerves and can be used for treating the diseases such as malaise, cardiopalmus dreaminess, can with the compatibilities such as Semen Ziziphi Spinosae, Cortex Albiziae, Caulis Polygoni Multiflori; Another and Radix Salviae Miltiorrhizae, Herba Leonuri, Herba Lycopi, the same use of Flos Carthami, can be used to treat the disease of abdominal pain in menstruation, soreness of the waist and knees, bone fracture and injury.Rhizoma et radix valerianae has quelling effect to central nervous system, when excited, can stabilize nerve, can help to refresh when fatigue.Contained Rhizoma et radix valerianae epoxy three esters of Rhizoma et radix valerianae root can help to alleviate spasm and pain, contribute to relax neuropathic dyspepsia, stomach spasm or enteritis.Total alkaloids in Rhizoma et radix valerianae has antibacterial action, especially can resist the infection that gram-positive bacterium is caused.The pink flower Rhizoma et radix valerianae of Rhizoma et radix valerianae can relieving insomnia, sleep disorder, flurried, anxiety neurosis and other imbalance diseases, also can relax one's muscles simultaneously, makes interior environment oil recover stable state.

Radix Polygalae: bitter, pungent, tepor; GUIXIN, kidney, lung meridian.< < Sheng Nong's herbal classic > >: ", except pathogen, sharp nine orifices, Fructus Alpiniae Oxyphyllae is intelligent for main cough with dyspnea damaging the spleen and stomach, tonifying for the deficiency, and normal hearing and eyesight is not forgotten, strong will times power." < < Japan hanako materia medica > >: " the frightened black mole of main diaphragm gas, longue meat, helps muscles and bones, married woman's blood aphonia of keeping silent, convulsive seizure induced by terror in children." Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.Epilepsy mania and irritation, spasm is twitched, skin sore.Modern pharmacological research shows, Radix Polygalae xylem haemolysis is low compared with skin zone.

Rhizoma Acori Graminei: nature and flavor are pungent, bitter, temperature.GUIXIN, stomach warp.Can removing dampness whet the appetite, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae., keep silent a mouthful dysentery not hungry for gastral cavity painful abdominal mass, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.< < does not record > > and records it: " warming intestines and stomach, stops normal urination for main deafness, carbuncle skin ulcer, and extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, body accumulated heat is not understood, and can bathe soup.Audition improvement order, beneficial intelligence." secretion of Rhizoma Acori Graminei decoct energy for oral administration facilitating digestion liquid and the abnormal fermentation of prevention gastrointestinal, and have the effect of alleviating intestinal tube smooth muscle spasm.The asaricin containing in Rhizoma Acori Graminei can resist the excitation of the intestine in vitro that barium chloride causes.

In above-mentioned external used medicine, the pharmacology of each raw medicinal material is as follows:

Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Pericarpium Zanthoxyli: pungent, temperature.Return spleen, stomach, kidney channel.Function cures mainly: warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.

Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet.Return kidney, spleen, the heart, Liver Channel.Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.For sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.< < Bencao Jingshu > > records: Ramulus Cinnamomi, Cortex Cinnamomi, Cortex Cinnamomi, and husband's five tastes sweet and pungent flavors inducing perspiration and pertaining to yang, four gas heat are sun also; The pure sun of taste, therefore energy dispersing wind and cold; Outside interior filling, therefore can show in fact; Pungent to fall apart it, heat is with row, sweet with and it, therefore can enter blood blood, moisten kidney dry.Its main benefitting liver and lung gas, headache, perspiration, only tired, only saliva, cough, Bi Weng, reason are dredged deficiency, exterior deficiency spontaneous perspiration, migratory arthralgia joint spasm and pain person, the institute of Ramulus Cinnamomi controls also.With its disease all exterior deficiency do not appoint wind and cold, due to cold-evil visitor, thus in knowing it, with it, can show in fact also eliminating evil.The cold disease of its main trusted subordinate's cold and heat, cramp caused by acute vomiting and diarrhea, lumbago, induced abortion, warming middle-JIAO, hard muscles and bones, promoting blood circulation, a surname lead hundred medicines without fear, mend again part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency, control chronic diseases, ooze let out, quench the thirst, only wind and cold, autumn and winter bottom stomachache affection of cold in Rong Wei, mend the gate of vitality, boosting source of fire for eliminating abundance of yin person, the institute of Cortex Cinnamomi controls also.Gas is thin to lightly float, and floating reaches table, thus Ramulus Cinnamomi control evil visitor's table minute for sick.Rich sweet pungent large heat, and in lower walking, therefore Cortex Cinnamomi, Cortex Cinnamomi are controlled the kidney-yang deficiency of the gate of vitality, yang deficiency is cold move in, and all interior deficiency YIN-cold, in cold-evil visitor is disease.Lid is sweet pungent and hot greatly with Cortex Cinnamomi, Cortex Cinnamomi, so Yiyang; Sweetly enter blood system, pungent energy is horizontal to be walked, and heat is current, closes this three, therefore benefaction blood.

Amylum Nelumbinis Rhizomatis: beneficial blood, hemostasis, in tune, appetizing.Control deficient losing blood, dysentery lack of appetite.1. < < explaining abstruseness of the canon of materia medica > >: " calm the nerves, appetizing." 2. < < herbal classic is met former > >: " controls deficient losing blood, vomiting and diarrhea hematochezia.Dysentery locked mouth can not be eaten again, be taken in small doses at short intervals tie excrement under, gastric qi from opening, just can be taken food." 3. < < detailed outline pick up any lost article from the road > >: " adjust in appetizing, mend marrow benefit blood, ventilation minute, clear exterior heat, the normal food raw wisdom of calming the nerves, expelling summer-heat promotes the production of body fluid, antidiarrheal helps digestion."

The Rhizoma Atractylodis Macrocephalae: be the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Return spleen, stomach warp, bitter in the mouth, sweet and warm in nature.Function invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.< < medicine origin > > records the Rhizoma Atractylodis Macrocephalae " dehumidifying benefit is dry, and middle QI invigorating, and warming middle-JIAO goes to wet in taste, and except gastric heat, strong taste, enter diet, quench the thirst, antiabortive "; < < Sheng Nong's herbal classic > > records the Rhizoma Atractylodis Macrocephalae " the sweet temperature of abnormal smells from the patient, nontoxic, control anemofrigid-damp arthralgia, dead flesh, convulsion subcutaneous ulcer, hidroschesis, heat extraction, help digestion "; The < < Yaoxing Fu > > record Rhizoma Atractylodis Macrocephalae " sweet in the mouth, temperature is nontoxic.Can rise and can fall, sun also.It is with having four: dredging water passages, has the merit of dehumidifying; Strong taste, have the effect of feed, and assistant Radix Scutellariae has antiabortive energy, and monarch's Fructus Aurantii Immaturus has the wonderful of the painful abdominal mass of disappearing ".

Aloe: under rushing down; Liver heat removing; Parasite killing.Main constipation with heat retention; Liver-fire headache; Conjunctival congestion infantile convulsion; Abdominal pain due to worm stagnation; Scabies; Hemorrhoid complicated by anal fistula; Solution Fructus Crotonis poison.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.1. < < property of medicine opinion > >: kill children's's infantile malnutrition ascarid.Head boil of malnutrition infant is killed in main nasal insufflation, except rhinocnesmus.2. < < Haiyao Bencao, Oversea Materia Medica > >: all infantile malnutrition with fever of main children's.3. < < Kaibao Bencao > >: main hot blast is unhappy, steam between chest and diaphragm, improving eyesight relieving palpitation, children epilepsy infantile convulsion, treats five kinds of child malnutrition, kills the sick skin ulcer fistula of three worms and hemorrhoid.Solution Fructus Crotonis poison.4. < < Bencao Tujing > >: control pruritus due to damp pathogen, that scratches has a yellow juice person; Control again the tooth of hideing.5. < < must join herbal > >: loose scrofula, control infantile convulsion, and diuretic is except swollen.6. < < book on Chinese herbal medicine new > > again: treating the liver fire, town liver-wind, the heat that clears away heart-fire, relaxing vexation, slakes thirst and help produce saliva, hearing-improing and eyesight improving, the tooth that disappears is swollen, separates fire-toxin.

The Radix Aucklandiae: promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot; Abdominal distention; Tell and have loose bowels; Heavy after dysentery.For heavy after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia.1. the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, belch, nausea and vomiting.2. the abdominal distention uncomfortable in chest of turbid damp obstructing in middle-JIAO, indigestion and loss of appetite loose stool.3. phlegm-damp is stopped up the cough and asthma of lung.4. pathogen, wards off malicious epidemic disease temperature ghost, strong will, and main pouring is revealed.Take for a long time not dream awake horrible nightmare.5. sterilization, kills terrible smart thing, pyrexial malaria diseases due to noxious agents produced by various parasites, and the bad QI-insufficiency of gas, partially cold in flesh, the essence of priming.

When the dosage form of endo-medicine is oral solutions, its preparation method comprises the following steps:

When the dosage form of endo-medicine is tablet, its preparation method comprises the following steps:

When the dosage form of external used medicine is navel patch, its preparation method comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 oral solutions

The embodiment of the present invention provides a kind of schizoid endo-medicine of heart kidney disorder type that is used for the treatment of, and dosage form is oral solutions, and in this medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 7 weight portions, Fructus Gardeniae 12 weight portions, Folium Bambusae 15 weight portions, Rhizoma Coptidis 21 weight portions, Rhizoma Bistortae 12 weight portions, the Radix Rehmanniae 7 weight portions, Radix Scrophulariae 12 weight portions, Cornu Bubali 5 weight portions, Lapis Micae Aureus 7 weight portions, Pheretima 12 weight portions, Radix Polygoni Multiflori Preparata 15 weight portions, Flos Rosae Rugosae 22 weight portions, FLOS MUME 12 weight portions, Nidus Vespae 17 weight portions, Radix Ranunculi Ternati 7 weight portions, Bombyx Batryticatus 19 weight portions, Succus Bambusae 12 weight portions, Concretio Silicea Bambusae 11 weight portions, Radix Platycodonis 15 weight portions, Bulbus Lilii 21 weight portions, Radix Asparagi 15 weight portions, Rhizoma Polygonati Odorati 11 weight portions, Rhizoma Polygonati 12 weight portions, Fructus Lycii 21 weight portions, Fructus Ligustri Lucidi 14 weight portions, Fructus Mori 21 weight portions, Carapax Et Plastrum Testudinis 6 weight portions, Folium Artemisiae Argyi 13 weight portions, Radix Trichosanthis 6 weight portions, Semen Ziziphi Spinosae 22 weight portions, Semen Platycladi 21 weight portions, Rhizoma et radix valerianae 12 weight portions, Radix Polygalae 12 weight portions and Rhizoma Acori Graminei 7 weight portions.

Its preparation method comprises the following steps:

Embodiment 2 tablets

The embodiment of the present invention provides a kind of schizoid endo-medicine of heart kidney disorder type that is used for the treatment of, and its dosage form is tablet, and in this medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 5 weight portions, Fructus Gardeniae 15 weight portions, Folium Bambusae 20 weight portions, Rhizoma Coptidis 25 weight portions, Rhizoma Bistortae 10 weight portions, the Radix Rehmanniae 5 weight portions, Radix Scrophulariae 10 weight portions, Cornu Bubali 3 weight portions, Lapis Micae Aureus 10 weight portions, Pheretima 10 weight portions, Radix Polygoni Multiflori Preparata 10 weight portions, Flos Rosae Rugosae 25 weight portions, FLOS MUME 15 weight portions, Nidus Vespae 25 weight portions, Radix Ranunculi Ternati 5 weight portions, Bombyx Batryticatus 25 weight portions, Succus Bambusae 10 weight portions, Concretio Silicea Bambusae 5 weight portions, Radix Platycodonis 10 weight portions, Bulbus Lilii 25 weight portions, Radix Asparagi 10 weight portions, Rhizoma Polygonati Odorati 15 weight portions, Rhizoma Polygonati 10 weight portions, Fructus Lycii 15 weight portions, Fructus Ligustri Lucidi 10 weight portions, Fructus Mori 15 weight portions, Carapax Et Plastrum Testudinis 3 weight portions, Folium Artemisiae Argyi 15 weight portions, Radix Trichosanthis 10 weight portions, Semen Ziziphi Spinosae 25 weight portions, Semen Platycladi 25 weight portions, Rhizoma et radix valerianae 16 weight portions, Radix Polygalae 10 weight portions and Rhizoma Acori Graminei 5 weight portions.

Its preparation method comprises the following steps:

Embodiment 3 navel patch

The embodiment of the present invention provides a kind of schizoid external used medicine of heart kidney disorder type that is used for the treatment of, its dosage form is navel patch, and in this medicine, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 15 weight portions, Pericarpium Zanthoxyli 7 weight portions, Radix Polygalae 8 weight portions, Cortex Cinnamomi 6 weight portions, Amylum Nelumbinis Rhizomatis 12 weight portions, the Rhizoma Atractylodis Macrocephalae 7 weight portions, Aloe 15 weight portions and the Radix Aucklandiae 7 weight portions.

Its preparation method comprises the following steps:

Toxicity test

One, acute oral toxicity test

(1) experiment purpose: acute oral toxicity effect and the intensity of the peroral tablets of the embodiment of the present invention 2 to mice.

(2) materials and methods:

A, tested material: peroral tablets of the present invention;

B, sample pre-treatments: take 15 duplicate samples, add 500ml boiled water, soak 2 hours, as stock solution;

C, experimental animal: I level Kunming mouse, 20, female, hero half and half, body weight 18-22g; By Shandong medical college Experimental Animal Center, provided.

(3) test method: dosage design is female is 6000m part/k part BW, and male is 6000m part/k part BW, gives tested material by 0.1ml/10 part BW per os gavage.Before gavage, animal fasting is 12 hours, freely drinks water.After gavage, give normal diet, observe two weeks, record poisoning symptom and death condition.

(4) result of the test: in 14 day observation period, animal subject is without abnormal response, without death, postmortem no abnormality seen.Female, male mice acute oral LD 50 is greater than 5000m part/k part/BW.According to acute toxicity grading criteria in < < disinfection technology standard > > (1999), judge the nontoxic level in the true border of peroral tablets of the present invention.

Two, cumulative toxicity test report

(1) test method: tested material is the oral solutions of the embodiment of the present invention 1; Select 20 healthy I level Kunming mouses, female, male each 10, it is first phase that dosage designs every 4 days, each issue dosage is respectively 0.10LD 50,0.15LD 50,0.22LD 50,0.34LD 50,0.50LD 50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 4 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, and cumulative coefficient is calculated in off-test.

(2) result of the test: press ascending-dose to 20 days handss of tested material, female, buck all occurs without death condition.Calculate cumulative coefficient and be greater than 5.According to cumulative toxicity grade scale in < < disinfection technology standard > > (1999), judge, tablet of the present invention belongs to weak cumulative toxicity to mice cumulative toxicity.

Three, acute skin irritation test report

(1) experiment purpose: detect navel patch to the stimulation/corrosiveness of laboratory animal skin and intensity.

(2) materials and methods:

A, tested material: the navel patch of the embodiment of the present invention 3;

B, tested material sample pre-treatments: take 15 duplicate samples, be heated to melt;

C, laboratory animal: the large ear white race of I level rabbit, 4, female, body weight 2.1-2.3k part; By Shandong medical college biology department Experimental Animal Center, provided.

(3) test method: select the healthy family that skin is intact to exempt from 4, its spinal column both sides, back were cut in first 24 hours to left and right each the about 3cm * 3cm of unhairing area in test by hair.During test, get on two layers of gauze that tested material 0.2ml is applied to 2.5cm * 2.5cm, be applied to a side skin of unhairing surface, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Seal after 4 hours, dismantle, and clean and go residual tested material with warm water, within 1,24 and 48 hour after removing tested material, observe and smear position dermoreaction, and scoring.

(4) experimental result: any erythema does not appear in laboratory animal skin, redness, inflammation phenomenon.According to skin irritation reaction standards of grading in < < disinfection technology standard > > (1999), judge, ointment of the present invention belongs to nonirritant to animal skin stimulus intensity.

Four, repeatedly skin irritation test testing result of the present invention is as follows:

(1) materials and methods:

22 ℃ ± 2 ℃ of a, experimental animal feeding environment room temperatures, relative humidity: 60%-70%;

B, experimental animal: Japan large ear rabbit; Animal rank: regular grade; 4, male; Body weight 2 kg-3kg;

C, animal origin: Shandong medical college biology laboratory provides.

(2) method: according to Ministry of Public Health < < cosmetics health standard > > (version in 2002) " skin irritation/corrosion test " the 6.4th " repeatedly skin irritation test ".Sample treatment: tested material (navel patch of the embodiment of the present invention 3) is heated to melt.Test procedure: 24h before test, with child's hair cutter, remove the hair of back part of animal spinal column both sides, remove scope 3cm * 3cm.Get tested material 0.5mL, spread upon on animal one side skin of unhairing, opposite side in contrast, application area 2.5cm * 2.5cm; Smear every day once, smear continuously 14d.Smear cropping at every turn, remove residual tested material.Observed result after 1h, with reference to the scoring of < < cosmetics health standard > > (version in 2002) " skin irritation/corrosion test " skin irritation reaction standards of grading.

(3) result: all animals were smeared in process at 14 days, there is not erythema and edema phenomenon in tested skin.Animal subject repeatedly skin irritation reacts average every day every animal integral mean value for " 0 ".

Clinical data

Case selection: case selection heart kidney disorder type schizophrenic 168 examples, male 80 examples, female's 88 examples, age 26-58 year, average 41.5 years old, the elder of medical history 4 years, the shortest person 4 months.168 routine patients are divided into 4 groups at random, and every group of 42 routine patients, are respectively treatment group 1, treatment group 2, treatment group 3 and matched group, after each sex, age, the course of disease and condition of illness of organizing patient contrasts, without the significance difference opposite sex, have statistical significance.

Diagnostic criteria: 1, have at least following two to be not secondary to disturbance of consciousness, disturbance of intelligence, elation or low, (1) recurrent verbal auditory ballucination; (2) significantly loosening of association, splitting of thought, speech are discontinuous, or the poverty of thought or poverty of content of thought; (3) thought be inserted into, withdrawn, sent out, thinking interruption or forced thinking; (4) passive, controlled, or known clearly experience; (5) vain hope of primary delusion or other absurdities; (6) thinking logic perversion, morbid symbolic thinking or neologism; (7) parathymia or obviously apathy; (8) tension syndrome, strange behavior or unwise behavior; (9) obvious hypobulia or shortage.2 and hope, hear, ask, cut the dialectical qi stagnation and blood stasis type prolapse of lumbar intervertebral disc that is further diagnosed as according to the traditional Chinese medical science.Meet above-mentioned 1,2 two condition, be diagnosed as heart kidney disorder type schizophrenia.Exclusion standard: get rid of organic mental disorders, psychoactive drug substance and non-addiction material caused by mental disorder.

Therapeutic Method:

Treatment group 1: take the tablet of the embodiment of the present invention 2, every day 3 times, each 44 weeks is a course for the treatment of, takes continuously 2-6 the course for the treatment of;

Treatment group 2: the navel patch of the external embodiment of the present invention 3, every day twice, each one is affixed on umbilicus place, within 4 weeks, is a course for the treatment of, takes continuously 2-6 the course for the treatment of;

Treatment group 3: take the oral solutions of the embodiment of the present invention 1 navel patch of the external embodiment of the present invention 3, oral solutions every day three times, each 30ml, navel patch every day twice, each one is affixed on umbilicus place; Within 4 weeks, be a course for the treatment of, take continuously 2-6 the course for the treatment of;

Matched group: take Clozaril, every day twice, each 25mg, 4 weeks is a course for the treatment of, takes continuously 2-6 the course for the treatment of.

Criterion of therapeutical effect: recovery from illness: psychotic symptoms disappears completely, and thinking compared with normal, is emotionally stable, it is normal that social function is recovered; Effective: psychotic symptoms is most of to disappear, and thinking compared with normal, is emotionally stable, and social function is obviously recovered, and insight has part to recover; Effective: psychotic symptoms partly disappears, thinking is more random, and emotion is flat, and insight partly recovers; Invalid: symptom is without improvement.

Therapeutic outcome:

Referring to table 1 and table 2, as can be seen from Table 1, adopt Drug therapy heart kidney disorder type schizophrenia of the present invention, with respect to conventional medicament, on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy heart kidney disorder type schizophrenia of the present invention, with respect to conventional medicament, treating significantly shortening on the course for the treatment of.

After each group of table 1 is treated respectively 6 courses for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Recovery from illness	Effective	Effectively	Invalid	Recovery from illness and obvious effective rate	Effective percentage
								Treatment group 1	42	13	14	10	5	（27）64.3%	88.1%
Treatment group 2	42	14	15	10	3	（29）69.0%	92.9%
								Treatment group 3	42	16	17	8	1	（33）78.6%	97.6%
Matched group	42	5	9	15	13	（14）33.3%	69.0%

Table 2 liang group is cured and effective number and time comparative example (%) after treating respectively 3 courses for the treatment of

Group	Number of cases	2-3 the course for the treatment of	4-5 the course for the treatment of	The 6th course for the treatment of
					Treatment group 1	27	8（29.6%）	11（40.7%）	8（29.6%）
Treatment group 2	29	9（31.0%）	12（41.4%）	8（27.6%）
					Treatment group 3	33	11（33.3%）	15（45.6%）	7（21.2%）
Matched group	14	3（21.4%）	5（35.7%）	6（42.9%）

Known according to the clinical statistics in above table, that medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; Each group healing and effective patient are followed up a case by regular visits to 1 year half simultaneously, result statistics, 27 routine patients in treatment group 1,1 example recurrence in 13 examples of recovery from illness, in 14 effective routine patients, 1 example recurs, and relapse rate is 7.4%; 29 routine patients in treatment group 2, in 14 examples of recovery from illness, without recurrence, in 15 effective routine patients, 1 example recurs, and relapse rate is 3.4%; 33 routine patients in treatment group 3, in 16 examples of recovery from illness, without recurrence, in 17 effective routine patients, 1 example recurs, and relapse rate is 3%; 14 routine patients in matched group, 1 example recurrence in 5 examples of recovery from illness, 2 example recurrences in 9 effective routine patients, relapse rate is 21.4%; And in therapeutic process, in matched group, there is patient to occur the side effect such as feeling sick in various degree, vomiting, and in treatment group 1-3, do not find any untoward reaction.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. be used for the treatment of the schizoid medicine of heart kidney disorder type, it is characterized in that, described medicine comprises endo-medicine and external used medicine, and described endo-medicine comprises following raw medicinal material: Mirabilitum crystallina, Fructus Gardeniae, Folium Bambusae, Rhizoma Coptidis, Rhizoma Bistortae, the Radix Rehmanniae, Radix Scrophulariae, Cornu Bubali, Lapis Micae Aureus, Pheretima, Radix Polygoni Multiflori Preparata, Flos Rosae Rugosae, FLOS MUME, Nidus Vespae, Radix Ranunculi Ternati, Bombyx Batryticatus, Succus Bambusae, Concretio Silicea Bambusae, Radix Platycodonis, Bulbus Lilii, Radix Asparagi, Rhizoma Polygonati Odorati, Rhizoma Polygonati, Fructus Lycii, Fructus Ligustri Lucidi, Fructus Mori, Carapax Et Plastrum Testudinis, Folium Artemisiae Argyi, Radix Trichosanthis, Semen Ziziphi Spinosae, Semen Platycladi, Rhizoma et radix valerianae, Radix Polygalae and Rhizoma Acori Graminei;

2. the schizoid medicine of heart kidney disorder type that is used for the treatment of according to claim 1, is characterized in that, in described endo-medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 5-9 weight portion, Fructus Gardeniae 10-15 weight portion, Folium Bambusae 10-20 weight portion, Rhizoma Coptidis 15-25 weight portion, Rhizoma Bistortae 10-15 weight portion, Radix Rehmanniae 5-15 weight portion, Radix Scrophulariae 10-15 weight portion, Cornu Bubali 3-9 weight portion, Lapis Micae Aureus 3-10 weight portion, Pheretima 10-15 weight portion, Radix Polygoni Multiflori Preparata 10-20 weight portion, Flos Rosae Rugosae 15-25 weight portion, FLOS MUME 10-15 weight portion, Nidus Vespae 10-25 weight portion, Radix Ranunculi Ternati 5-10 weight portion, Bombyx Batryticatus 15-25 weight portion, Succus Bambusae 10-15 weight portion, Concretio Silicea Bambusae 5-15 weight portion, Radix Platycodonis 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Asparagi 10-20 weight portion, Rhizoma Polygonati Odorati 5-15 weight portion, Rhizoma Polygonati 10-15 weight portion, Fructus Lycii 15-25 weight portion, Fructus Ligustri Lucidi 10-17 weight portion, Fructus Mori 15-25 weight portion, Carapax Et Plastrum Testudinis 3-8 weight portion, Folium Artemisiae Argyi 10-15 weight portion, Radix Trichosanthis 5-10 weight portion, Semen Ziziphi Spinosae 10-25 weight portion, Semen Platycladi 15-25 weight portion, Rhizoma et radix valerianae 9-16 weight portion, Radix Polygalae 10-15 weight portion and Rhizoma Acori Graminei 5-12 weight portion,

3. the schizoid medicine of heart kidney disorder type that is used for the treatment of according to claim 1 and 2, is characterized in that, in described endo-medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 7 weight portions, Fructus Gardeniae 12 weight portions, Folium Bambusae 15 weight portions, Rhizoma Coptidis 21 weight portions, Rhizoma Bistortae 12 weight portions, the Radix Rehmanniae 7 weight portions, Radix Scrophulariae 12 weight portions, Cornu Bubali 5 weight portions, Lapis Micae Aureus 7 weight portions, Pheretima 12 weight portions, Radix Polygoni Multiflori Preparata 15 weight portions, Flos Rosae Rugosae 22 weight portions, FLOS MUME 12 weight portions, Nidus Vespae 17 weight portions, Radix Ranunculi Ternati 7 weight portions, Bombyx Batryticatus 19 weight portions, Succus Bambusae 12 weight portions, Concretio Silicea Bambusae 11 weight portions, Radix Platycodonis 15 weight portions, Bulbus Lilii 21 weight portions, Radix Asparagi 15 weight portions, Rhizoma Polygonati Odorati 11 weight portions, Rhizoma Polygonati 12 weight portions, Fructus Lycii 21 weight portions, Fructus Ligustri Lucidi 14 weight portions, Fructus Mori 21 weight portions, Carapax Et Plastrum Testudinis 6 weight portions, Folium Artemisiae Argyi 13 weight portions, Radix Trichosanthis 6 weight portions, Semen Ziziphi Spinosae 22 weight portions, Semen Platycladi 21 weight portions, Rhizoma et radix valerianae 12 weight portions, Radix Polygalae 12 weight portions and Rhizoma Acori Graminei 7 weight portions,

In described medicine for external use thing, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 15 weight portions, Pericarpium Zanthoxyli 7 weight portions, Radix Polygalae 8 weight portions, Cortex Cinnamomi 6 weight portions, Amylum Nelumbinis Rhizomatis 12 weight portions, the Rhizoma Atractylodis Macrocephalae 7 weight portions, Aloe 15 weight portions and the Radix Aucklandiae 7 weight portions.

4. according to being used for the treatment of the schizoid medicine of heart kidney disorder type described in claim 1-3 any one, it is characterized in that, in described endo-medicine, the parts by weight of each raw medicinal material are: Mirabilitum crystallina 5 weight portions, Fructus Gardeniae 15 weight portions, Folium Bambusae 20 weight portions, Rhizoma Coptidis 25 weight portions, Rhizoma Bistortae 10 weight portions, the Radix Rehmanniae 5 weight portions, Radix Scrophulariae 10 weight portions, Cornu Bubali 3 weight portions, Lapis Micae Aureus 10 weight portions, Pheretima 10 weight portions, Radix Polygoni Multiflori Preparata 10 weight portions, Flos Rosae Rugosae 25 weight portions, FLOS MUME 15 weight portions, Nidus Vespae 25 weight portions, Radix Ranunculi Ternati 5 weight portions, Bombyx Batryticatus 25 weight portions, Succus Bambusae 10 weight portions, Concretio Silicea Bambusae 5 weight portions, Radix Platycodonis 10 weight portions, Bulbus Lilii 25 weight portions, Radix Asparagi 10 weight portions, Rhizoma Polygonati Odorati 15 weight portions, Rhizoma Polygonati 10 weight portions, Fructus Lycii 15 weight portions, Fructus Ligustri Lucidi 10 weight portions, Fructus Mori 15 weight portions, Carapax Et Plastrum Testudinis 3 weight portions, Folium Artemisiae Argyi 15 weight portions, Radix Trichosanthis 10 weight portions, Semen Ziziphi Spinosae 25 weight portions, Semen Platycladi 25 weight portions, Rhizoma et radix valerianae 16 weight portions, Radix Polygalae 10 weight portions and Rhizoma Acori Graminei 5 weight portions,

In described medicine for external use thing, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 20 weight portions, Pericarpium Zanthoxyli 10 weight portions, Radix Polygalae 5 weight portions, Cortex Cinnamomi 8 weight portions, Amylum Nelumbinis Rhizomatis 15 weight portions, the Rhizoma Atractylodis Macrocephalae 9 weight portions, Aloe 20 weight portions and the Radix Aucklandiae 12 weight portions.

5. according to the preparation method that is used for the treatment of the schizoid medicine of heart kidney disorder type described in claim 1-4 any one, it is characterized in that, the dosage form of described endo-medicine is oral solutions, and its preparation method comprises the following steps:

6. according to the preparation method that is used for the treatment of the schizoid medicine of heart kidney disorder type described in claim 1-4 any one, it is characterized in that, the dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps:

7. according to the preparation method that is used for the treatment of the schizoid medicine of heart kidney disorder type described in claim 1-4 any one, it is characterized in that, the dosage form of described external used medicine is navel patch, and its preparation method comprises the following steps: