CN104013950A - Traditional Chinese medicine composition for treating toxin and decay type bedsore and preparation method of composition - Google Patents

Traditional Chinese medicine composition for treating toxin and decay type bedsore and preparation method of composition Download PDF

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CN104013950A
CN104013950A CN201410309324.3A CN201410309324A CN104013950A CN 104013950 A CN104013950 A CN 104013950A CN 201410309324 A CN201410309324 A CN 201410309324A CN 104013950 A CN104013950 A CN 104013950A
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radix
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rhizoma
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张德玲
王红艳
宋晶
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Geng Zhaoxia
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Abstract

The invention discloses a traditional Chinese medicine composition for treating toxin and decay type bedsore and a preparation method of the composition. The traditional Chinese medicine composition comprises codonopsis pilosula, astragalus membranaceus, bighead atractylodes rhizome, Chinese yam, schizonepeta, betel pepper leaves, dendrobe, tamarix chinensis, tremella, honeysuckle, fructus viticis, sealwort, radices trichosanthis, lophatherum gracile, radix sophorae flavescentis, semen cuscutae, senecio argunensis trucz, meadowrue root and rhizome, grifola, radix gentianae, fructus broussonetiae, salviae miltiorrhizae, radix polygonati officinalis, Chinese-dates, adenophora tetraphylla, gingers, pearl essence, fructus kochiae, yam rhizome and hypericum japonicum. The traditional Chinese medicine composition disclosed by the invention has the beneficial effects that the traditional Chinese medicine composition which mainly treats toxin and decay type bedsore by means of theory of traditional Chinese medicines has the functions of tonifying qi and yin and removing dampness and eliminating toxin, and improves the integral immunity and the disease-resistant ability of the human body during syndrome differentiation and treatment; the composition prevents wound infection, expansion and deepening, eliminates putridity and engenders flesh, promotes blood circulation, improves the repair ability of the wound, promote union and the like; the composition is simple to prepare, low in cost, convenient to deliver, good in curative effect, high in cure rate, free from toxic and side effects and quick in effect and the disease is not easy to relapse.

Description

Chinese medicine composition of malicious decomposed type decubital ulcer and preparation method thereof is accumulate in a kind for the treatment of
 
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly Chinese medicine composition of malicious decomposed type decubital ulcer and preparation method thereof is accumulate in a kind for the treatment of.
 
Background technology
Decubital ulcer (decubitus) has another name called pressure ulcer (pressure sores), is that the long-term pressurized of body part is obstructed blood circulation, and the skin causing and subcutaneous tissue ischemia and vesicle, ulcer or gangrene occur.Primary disease is similar to " bed-sore " recorded in motherland medical literature.As.Surgery is really annotated 〃 bed-sore and is recorded: " bed-sore is the people of prolonged illness implantation, suffers that scouring is broken to be formed, upper and ridge, lower and lower reaches." in general, long-term bed, have bad physiques, stand up inconvenience and limbs sensation laggards and easily suffer from decubital ulcer, be more common in clinically following three class patients: 1. stupor and paralytic.2. be unable to leave the bed, the patient who has bad physiques.3. the patient who fixes or lie in bed for a long time after fracture.
Etiology and pathology is that the long-term pressurized of body part is obstructed blood circulation, and the skin causing and subcutaneous tissue ischemia and vesicle, ulcer or gangrene occur.Long-term compressing due to above reason and concentrate on a certain position of health, is enough to make blood circulation be obstructed and cause histanoxia, thereby causes tissue injury and necrosis.If continue pressurized, can cause holostrome cutaneous necrosis damaged.The ulcer producing easily causes antibacterial to infect.Blood capillary and venous congestion due to ulcer base portion and edge, in addition form gradually a large amount of granulation tissuies, make ulcer or gangrenous district in the subcutaneous expansion of giving a farfetched interpretation rapidly, within a couple of days, can make its diameter reach 3~6cm, the scope of giving a farfetched interpretation can be apart from edge 8~10cm, to deep development, even sclerotin of periosteum be can involve, focal periostitis or osteomyelitis caused.
Symptom and sign: the multiple skeleton projection pressurized position of being born in, according to its occur, evolution can be divided into three degree: once: part only shows as erythema edema, or pale asphyxia, cinerous, boundary was clear.There are feeling of numbness or tenderness.If process in time, can take a turn for the better within a couple of days.Two degree: skin color is darkviolet or atropurpureus, can occur vesicle, forms the rotten to the corn face of shallow table after bleb wall breaks.Three degree: ulcer, shallow person reaches subcutaneous tissue, and dark person can reach osseous tissue, and after secondary infection, pus is many, and frowziness.Complication: can involve even sclerotin of periosteum to deep development, cause focal periostitis or osteomyelitis.
Western medical treatment decubital ulcer thinks and start early, and principle is to remove affected part compressing, promotes local blood circulation, strengthens wound surface and processes.Once decubital ulcer should regularly massage, changing position, local alcohol rub or infrared ray radiation, if inflammation is remarkable, available 0.5% neomycin solution soak.Two degree decubital ulcers can be coated with outward after antimicrobial ointment coated with sterile gauze.Three degree decubital ulcers should be carried out debridement treatment, and the little person of ulcer can external 0.5% silver nitrate soak, to remove infection.Can external promote the medicine that granulation tissue forms simultaneously.Ulcer is large and purifier can adopt layering grafts, or coated with holostrome flap.To sloughing ulcer, should remove slough, fully after drain, do again above-mentioned processing.For wound surface pus, should often cultivate and do drug sensitive test, thereby instruct, select sensitive antibiotic external.If without systemic infection sign, generally do not need system to use antibiotic.In addition for patient with severe symptoms, should strengthen supporting treatment.But western medical treatment decubital ulcer lacks effective medicine kind, therapeutic scheme is limited, and the course for the treatment of is longer, and curative effect is not satisfactory, causes certain psychological burden to patient and family members, and stress, has a strong impact on patient's quality of life.
The traditional Chinese medical science thinks, decubital ulcer is due to excessive rest on bed impairing QI, the deficiency of vital energy and hematogenous blockage; Because somatotopic is oppressed for a long time continuously and rubs, cause blood stasis due to qi deficiency outward, local failure of skin and muscle to be nourished, skin and flesh necrosis forms.From the beginning of pressurized position, occur dark redly, gradually dark violet, become rapidly black dead skin, pain or not bitterly, dead skin with form obviously boundary around, the flat undiscipline of collapsing of swollen gesture around.The dead skin and normal skin boundary of continuing liquefies and festers gradually, and pus is smelly dirty, rots to expand to dead skin below from wound surface surrounding, after dead skin comes off, forms larger ulcer surface, can be deeply and fascia, flesh layer, periosteum.If wound surface rots to organize gradually and comes off, there is cerise granulation, create the very fast person of all skin growths, decubital ulcer is expected healing.If rot, spread incessantly, ulcer surface day by day expands, and around swollen gesture continues development, ulcer surface has celadon pus stench thin, or as powder slurry sewage, and the weak thin person of shape of the companion body, decubital ulcer delay is difficult, even occurs that septicopyemia is walked to alter, the heavily card of interior biography internal organs, and prognosis is poor.
Dialectical analysis is following disease: 1. syndrome of qi stagnation and blood stasis disease: brown erythema appears in local skin, then purple dark red swollen, or has breakage; Thin fur, tongue limit has the stasis of blood purple, stringy pulse.Method for the treatment of: vital energy regualting and blood circulation-promoting.2. accumulate malicious decomposed card disease: decubital ulcer is festered, and slough and pus are more, or foul smelling, severe one is festered can be deeply and muscles and bones, and surrounding is unrestrained to swell; With heating or low grade fever, bitter taste and dry, lethargy, anorexia; Red tongue, tongue is few, thready and rapid pulse.3. deficiency of both QI and blood disease: wound surface slough is difficult de-, though or slough de-, new flesh color is light, indolence; Companion's lusterless complexion, spiritlessness and weakness, poor appetite lack of appetite; Light red tongue, tongue is few, deep,thready and forceless pulse.Method for the treatment of: qi and blood tonifying, detoxification granulation promoting.
 
Summary of the invention
Technical problem to be solved by this invention is, a kind of supplementing QI and nourishing YIN that has is provided, and reason wet care poison function, can treat the Chinese medicine composition that accumulates malicious decomposed type decubital ulcer.The present invention utilizes Traditional Chinese medical theory, is particular about Overall View, improves the immunity of animal economy in determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, improves the ability of disease-resistant heresy; Prevent traumatic infection, expansion, intensification, removing the necrotic tissue and promoting granulation, blood circulation promoting, the repair ability of raising wound surface, promotes healing etc.; Make simply, cost price is low, convenient drug administration, and patient is easy to accept, good effect, cure rate is high, and curative effect is fast, has no side effect, and is difficult for more afterwards recurrence.
In order to realize foregoing invention object, the invention provides a kind for the treatment of and accumulate the Chinese medicine composition of malicious decomposed type decubital ulcer, described Chinese medicine composition comprises following crude drug: Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Herba Schizonepetae, Folium piperis betlis, Herba Dendrobii, Ramulus et Folium Tamaricis, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Radix Sophorae Flavescentis, Semen Cuscutae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, Radix Rhodiolae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens, Margarita powder, Fructus Kochiae, Rhizoma Dioscoreae Septemlobae and Herba Hyperici Japonici.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each crude drug is: Radix Codonopsis 5-12 weight portion, Radix Astragali 10-30 weight portion, Rhizoma Atractylodis Macrocephalae 12-26 weight portion, Rhizoma Dioscoreae 10-27 weight portion, Herba Schizonepetae 10-25 weight portion, Folium piperis betlis 14-22 weight portion, Herba Dendrobii 15-30 weight portion, Ramulus et Folium Tamaricis 5-11 weight portion, Tremella 10-25 weight portion, Flos Lonicerae 12-36 weight portion, Fructus Viticis 14-26 weight portion, Rhizoma Polygonati 10-24 weight portion, Radix Trichosanthis 12-25 weight portion, Herba Lophatheri 14-25 weight portion, Radix Sophorae Flavescentis 4-12 weight portion, Semen Cuscutae 5-12 weight portion, Herba Senecionis Argunensis 15-28 weight portion, Radix et Rhizoma Thalictri 10-32 weight portion, Polyporus 4-10 weight portion, Radix Gentianae 15-34 weight portion, Radix Rhodiolae 15-32 weight portion, Fructus Broussonetiae 10-25 weight portion, Radix Salviae Miltiorrhizae 12-35 weight portion, Rhizoma Polygonati Odorati 15-25 weight portion, Fructus Jujubae 15-30 weight portion, Radix Adenophorae 12-25 weight portion, Rhizoma Zingiberis Recens 10-28 weight portion, Margarita powder 5-8 weight portion, Fructus Kochiae 15-34 weight portion, Rhizoma Dioscoreae Septemlobae 12-28 weight portion and Herba Hyperici Japonici 10-32 weight portion.
In described Chinese medicine composition, the ratio of weight and number of each crude drug is preferably: Radix Codonopsis 5-8 weight portion, Radix Astragali 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 12-16 weight portion, Rhizoma Dioscoreae 10-17 weight portion, Herba Schizonepetae 15-25 weight portion, Folium piperis betlis 18-22 weight portion, Herba Dendrobii 15-20 weight portion, Ramulus et Folium Tamaricis 5-9 weight portion, Tremella 10-15 weight portion, Flos Lonicerae 12-16 weight portion, Fructus Viticis 20-26 weight portion, Rhizoma Polygonati 10-14 weight portion, Radix Trichosanthis 12-15 weight portion, Herba Lophatheri 14-18 weight portion, Radix Sophorae Flavescentis 4-7 weight portion, Semen Cuscutae 5-7 weight portion, Herba Senecionis Argunensis 15-20 weight portion, Radix et Rhizoma Thalictri 20-32 weight portion, Polyporus 4-16 weight portion, Radix Gentianae 15-24 weight portion, Radix Rhodiolae 15-22 weight portion, Fructus Broussonetiae 10-15 weight portion, Radix Salviae Miltiorrhizae 22-35 weight portion, Rhizoma Polygonati Odorati 15-20 weight portion, Fructus Jujubae 15-20 weight portion, Radix Adenophorae 20-25 weight portion, Rhizoma Zingiberis Recens 10-18 weight portion, Margarita powder 5-7 weight portion, Fructus Kochiae 25-34 weight portion, Rhizoma Dioscoreae Septemlobae 12-18 weight portion and Herba Hyperici Japonici 20-32 weight portion.
In described Chinese medicine composition, the ratio of weight and number of each crude drug can also be preferably: Radix Codonopsis 7 weight portions, the Radix Astragali 20 weight portions, the Rhizoma Atractylodis Macrocephalae 16 weight portions, Rhizoma Dioscoreae 17 weight portions, Herba Schizonepetae 15 weight portions, Folium piperis betlis 14 weight portions, Herba Dendrobii 30 weight portions, Ramulus et Folium Tamaricis 5 weight portions, Tremella 15 weight portions, Flos Lonicerae 16 weight portions, Fructus Viticis 20 weight portions, Rhizoma Polygonati 14 weight portions, Radix Trichosanthis 15 weight portions, Herba Lophatheri 18 weight portions, Radix Sophorae Flavescentis 5 weight portions, Semen Cuscutae 6 weight portions, Herba Senecionis Argunensis 18 weight portions, Radix et Rhizoma Thalictri 22 weight portions, Polyporus 6 weight portions, Radix Gentianae 24 weight portions, Radix Rhodiolae 22 weight portions, Fructus Broussonetiae 15 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Rhizoma Polygonati Odorati 20 weight portions, Fructus Jujubae 20 weight portions, Radix Adenophorae 15 weight portions, Rhizoma Zingiberis Recens 18 weight portions, Margarita powder 6 weight portions, the Fructus Kochiae 24 weight portions, Rhizoma Dioscoreae Septemlobae 18 weight portions and Herba Hyperici Japonici 22 weight portions.
In described Chinese medicine composition, the ratio of weight and number of each crude drug can also be preferably: Radix Codonopsis 5 weight portions, the Radix Astragali 20 weight portions, the Rhizoma Atractylodis Macrocephalae 25 weight portions, Rhizoma Dioscoreae 20 weight portions, Herba Schizonepetae 16 weight portions, Folium piperis betlis 15 weight portions, Herba Dendrobii 22 weight portions, Ramulus et Folium Tamaricis 5 weight portions, Tremella 15 weight portions, Flos Lonicerae 14 weight portions, Fructus Viticis 20 weight portions, Rhizoma Polygonati 15 weight portions, Radix Trichosanthis 22 weight portions, Herba Lophatheri 15 weight portions, Radix Sophorae Flavescentis 5 weight portions, Semen Cuscutae 5 weight portions, Herba Senecionis Argunensis 20 weight portions, Radix et Rhizoma Thalictri 25 weight portions, Polyporus 4 weight portions, Radix Gentianae 20 weight portions, Radix Rhodiolae 20 weight portions, Fructus Broussonetiae 15 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Rhizoma Polygonati Odorati 20 weight portions, Fructus Jujubae 25 weight portions, Radix Adenophorae 12 weight portions, Rhizoma Zingiberis Recens 10 weight portions, Margarita powder 5 weight portions, the Fructus Kochiae 15 weight portions, Rhizoma Dioscoreae Septemlobae 12 weight portions and Herba Hyperici Japonici 15 weight portions.
When the dosage form of Chinese medicine composition is patch, its preparation method is:
A. get in proportion raw medicinal material Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, the Fructus Kochiae He Rhizoma Dioscoreae Septemlobae, add in the ethanol of the 80-95% that 2-3 doubly measures, heating and refluxing extraction 2 times, each 30-50 minute, filtration obtains medicinal residues and extracting solution, and extracted twice liquid is merged into the first extracting solution;
B. more above-mentioned medicinal residues and surplus stock Yao Cai Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens and Herba Hyperici Japonici are added in proportion to the water heating and refluxing extraction 2 times that 2-5 doubly measures; each 30-50 minute, merge extractive liquid, obtains the second extracting solution;
C. the first extracting solution and the second extracting solution are merged, in the extracting solution suction concentrating under reduced pressure tank after merging, be decompressed to 0.05-0.10MPa, the extractum that while being concentrated into temperature to 67 ℃-81 ℃, relative density is 1.21; Heating is concentrated into pasty state, with wine, vinegar, Mel and described Margarita powder, is in harmonious proportion and spreads on skin lesion place, pastes medicine part and need clean, and with preservative film, medical adhesive tape, fixes.
When the dosage form of Chinese medicine composition is liniment, its preparation method is:
The first step: get in proportion crude drug Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, the mixing of Fructus Kochiae, Rhizoma Dioscoreae Septemlobae, put into the 80-95% ethanol that mixture 1-3 doubly measures, soak 15-25 minute, then heating extraction is 2 times, each 15-25 minute; The concentrated ethanol extract of heating, the concentrated solution that when being concentrated into temperature and being 85-90 ℃, relative density is 1.02, stand for standby use;
Second step: Yuan Liao Yao Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens, Margarita powder, Herba Hyperici Japonici described in all the other are mixed by proportioning, drop into pulverizer and be ground into fine powder, fine powder sieves after 100-150 order and puts into acid and alkali-resistance infusion kettle, at normal temperatures and pressures, the ethanol that is 85-93% with concentration floods 10-20 days jointly, squeeze, after isolated by filtration, get filtrate;
The 3rd step: described filtrate and described concentrated solution is mixed; Described mixed liquid heating is concentrated into pasty state, puts into after baking oven 78-89 ℃ oven dry coolingly, be ground into powder and mix vaseline and make liniment.
Wherein, the dosage form of described Chinese medicine composition is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, liniment, enema and patch.
The invention has the beneficial effects as follows: Chinese medicine composition of the present invention utilizes Traditional Chinese medical theory to cure mainly to accumulate malicious decomposed type decubital ulcer, have supplementing QI and nourishing YIN, the effect of reason wet care poison improves the immunity of animal economy in determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, improves the ability of disease-resistant heresy; Prevent traumatic infection, expansion, intensification, removing the necrotic tissue and promoting granulation, blood circulation promoting, the repair ability of raising wound surface, promotes healing etc.; Make simply, cost price is low, convenient drug administration, and good effect, cure rate is high, has no side effect, and curative effect is fast, is not easy recurrence.
 
The specific embodiment
Chinese medicine thinks, the traditional Chinese medical science thinks, decubital ulcer is due to excessive rest on bed impairing QI, the deficiency of vital energy and hematogenous blockage; Because somatotopic is oppressed for a long time continuously and rubs, cause blood stasis due to qi deficiency outward, local failure of skin and muscle to be nourished, skin and flesh necrosis forms.Intensive care is answered in treatment, focuses on prevention.External treatment is main, coordinates Inner to control.Active treatment general disease, and give necessary supporting treatment, nutrition is careful in one's diet.
Therefore, the present invention treats decubital ulcer and accumulates malicious decomposed card, with supplementing QI and nourishing YIN, reason wet care poison is primary treatment principle, a kind of Chinese medicine composition for the treatment of decubital ulcer is provided, comprises: Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Herba Schizonepetae, Folium piperis betlis, Herba Dendrobii, Ramulus et Folium Tamaricis, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Radix Sophorae Flavescentis, Semen Cuscutae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, Radix Rhodiolae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens, Margarita powder, Fructus Kochiae, Rhizoma Dioscoreae Septemlobae and Herba Hyperici Japonici.
Wherein, Herba Schizonepetae, Ramulus et Folium Tamaricis, Flos Lonicerae, Herba Senecionis Argunensis, Fructus Viticis heat-clearing and toxic substances removing, poison holding dispels the wind; Radix Trichosanthis, Herba Lophatheri, Radix Sophorae Flavescentis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae heat clearing and damp drying, eliminating carbuncle pain relieving; Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Semen Cuscutae, Radix Rhodiolae, Fructus Broussonetiae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Herba Dendrobii, Rhizoma Polygonati, Tremella benefiting qi and nourishing yin; Rhizoma Zingiberis Recens, Fructus Kochiae, Rhizoma Dioscoreae Septemlobae, Herba Hyperici Japonici reason wet, eliminating carbuncle poison holding; Folium piperis betlis, Margarita powder, Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, removing the necrotic tissue and promoting granulation.
Now each taste medicine is described below:
Herba Schizonepetae: acrid in the mouth, micro-hardship, property is micro-wet; Enter lung, Liver Channel.< < detailed outline > >: " loose wind heat, refresh oneself, throat, the skin ulcer that disappears is swollen.Control stiffness of the nape, black flower in order, and raw skin ulcer, cloudy ruined, spit blood, epistaxis, hematochezia, dysentery, metrorrhagia, anal fistula." main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.
Folium piperis betlis: pungent; Temperature, returns lung; Stomach warp; Function cures mainly: expelling wind and cold, and promoting the circulation of QI and reducing phlegm, removing toxic substances and promoting subsidence of swelling, dry temperature is antipruritic.。Main cough due to wind and cold, asthma, pertussis, institute's abdominal distention and pain, dyspepsia is indigestion and loss of appetite, edema, traumatic injury wound is swollen, rheumatic ostalgia, sore swollen toxin, swelling and pain of hemorrhoid, burn, pathogenic wind-toxic beriberi, mange, eczema epidemic disease is itched.< < Luchuan book on Chinese herbal medicine > >: " anthelmintic, detumescence, antipruritic, removing the necrotic tissue and promoting granulation.Control infantile malnutrition furuncle, ulcer, carious pain."
Herba Dendrobii: sweet, be slightly cold.Return stomach, kidney channel.Function cures mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.For cloudy impairment of body fluid, lose, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.
Ramulus et Folium Tamaricis: sweet in the mouth, pungent, property are flat; Return lung meridian, stomach warp, heart channel.< < Bencao Beiyao > >: " control acute diseases such as cholera and sunstroke rash and do not go out, breathe heavily the vexed unrest of coughing." function dispelling wind, induce sweat, rash, removing toxic substances.Cure mainly anemopyretic cold, measles from the beginning of, rash goes out not saturating, rheumatic arthralgia, skin pruritus.Control measles thoroughly difficult, rubella itching over the body, flu, cough with asthma, rheumatic ostalgia.
Tremella: sweet, flat.Function cures mainly: invigorating the lung and benefiting vital QI, nourishing YIN to relieve dryness.For body is empty after being ill, chronic cough of deficiency lung, sputum mixed with blood, metrorrhagia, constipation, hypertension, sclerosis of blood vessels.
Flos Lonicerae: sweet; Cold, return lung; Stomach warp; Function cures mainly: heat-clearing and toxic substances removing.Main epidemic febrile disease heating; Toxic-heat and blood stasis; Carbuncle furuncle; Sore throat and multi-infection disease
Fructus Viticis: pungent, bitter, be slightly cold; Return bladder, liver, stomach warp.< < Sheng Nong's herbal classic > >: " bitter in the mouth is slightly cold.Cure mainly cold and heat between muscles and bones, arthralgia chiefly caused by damp pathogen, contracture, improving eyesight, hard Fructus Viticis tooth, sharp nine orifices, removes tapeworm." < < medicine class on the analogy of natural things > >: " and control Taiyang channel headache, dizzy vexed, remove dizzy order dark.The medicine of loose ailment said due to cold or exposure also.If the people of insufficiency of stomach-QI can not take, probably raw expectorant disease." dispelling wind and heat pathogens, the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.Fructus Viticis has obvious hypotensive effect, and its hypotensive effect is relevant with the parasympathetic nervous system of excited maincenter induction.
Rhizoma Polygonati: sweet, flat.Return spleen, lung, kidney channel.Function cures mainly: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Radix Trichosanthis: sweet, micro-hardship, is slightly cold; Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.The just > > of < < book on Chinese herbal medicine: " medicine so-called Radix Trichosanthis person wantonly, with the undercut sheet that withers with it, have the name of powder, without the reality of powder.It smashes the method for thin clear powder." the < < book on Chinese herbal medicine > > that looks for the truth: " and Radix Trichosanthis, than Fructus Trichosanthis, its property is slightly flat, impatient the compeling of seemingly not withering, and have the wall of pushing away fall wall merit also.To < <, through > >, there is speech regulating the spleen and stomach to continue exhausted, like non-, just say, but its evanescence of heat of cloud is from the meaning of peace." for calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.
Herba Lophatheri: nature and flavor, sweet, be slightly cold.< < Compendium of Materia Medica > >: " go dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, children's's pox poison, outer disease is vicious." effect clearing heat and relieving fidgetness, inducing diuresis for treating stranguria syndrome.< < vegetation is square > > just: " expectorant is quenched the thirst.Control dysphoria with smothery sensation, cough with asthma, spits blood, the sound of vomiting of vomitting, pediatric epilepsy scared." for calentura excessive thirst, heart stomach-fire is contained.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature; Return liver, kidney, large intestine, small intestine meridian, bladder, heart channel, urinary bladder channel.< < Amplification on Materia Medica addendum > >: " Radix Sophorae Flavescentis, can high nourishing YIN gas, or and cause waist severe one, because its gas falls, do not rise yet, non-meaning of being impairment of the kidney also.It is meritorious that it controls strong wind, the thin rash of condition wind heat." < < book on Chinese herbal medicine is through hundred kinds of record > >: " Radix Sophorae Flavescentis, specially controls the fire of heart channel, close with Rhizoma Coptidis function.But it is many that Rhizoma Coptidis seemingly removes the fire of heart, it is many that Radix Sophorae Flavescentis seemingly removes the fire of heart internal organs small intestinal, clear with the abnormal smells from the patient of Rhizoma Coptidis, and the abnormal smells from the patient of Radix Sophorae Flavescentis is also turbid.By invigorating middle warmer two words, also get its hardship with the justice of dry spleen also." can heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy.
Semen Cuscutae: sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, and controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Herba Senecionis Argunensis: micro-hardship, cold.Function cures mainly: heat-clearing and toxic substances removing.For venom, scorpion, bee sting wound, furuncle toxic swelling, eczema, dermatitis, acute conjunctivitis, pharyngitis.
Radix et Rhizoma Thalictri: nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication.Control damp-heat dysentery, jaundice, calentura is irritated, cough due to lung-heat, carbuncle pyogenic infections from tumour or sore, conjunctival congestion and swelling pain.Be applied to now enteritis, infectious hepatitis, flu, measles, carbuncle furuncle, conjunctivitis.
Polyporus: sweet, light, flat.Return kidney, urinary bladder channel.Function cures mainly: promoting diuresis to eliminate damp pathogen.For dysuria, edema, has loose bowels, stranguria with turbid discharge, leukorrhagia.
Radix Gentianae: bitter in the mouth, cold in nature; Return liver, gallbladder meridian.< < Compendium of Materia Medica > >: " treat throat pain, wind heat night sweat.Fire is posted in liver and gall mutually, have rush down of no help, therefore the gas of the liver benefiting gallbladder of Radix Gentianae, just with its can eliminating pathogen in the liver gallbladder pathogenic heat also.< < is the making us excessive and can't help of bait on an empty stomach, thus with its too hardship let out too far also down." < < property of medicine opinion > >: " main pediatric epilepsy scared enters the heart, high fever bone heat, carbuncle; While controlling, disease heat is yellow, aphtha." function heat clearing and damp drying, eliminating pathogen in the liver arresting convulsion.Cure mainly jaundice due to damp-heat, urine leaching pain, swelling of the vulva pudendal pruritus, damp-heat vaginal discharge, the feeling of fullness in the head headache of liver and gall excess-fire, conjunctival congestion and swelling pain, deaf ear is swollen, hypochondriac pain bitter taste, calentura convulsion with spasms.
Radix Codonopsis: property is flat, sweet in the mouth, micro-acid; Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.These product are clinical conventional Qi-tonifying drug, function invigorating the spleen to benefit the lung, effect person of modern times ginseng and for a little less than, be applicable to various deficiency of vital energy deficiency persons.Contained saponin, inulin, Alkaloid, starch etc. have strong effect in various degree to the many internal organs of human body, can improve the adaptability of human body.There is antiulcer, can increase intestinal tension force, regulate stomach motion, in the intestines and stomach coordinating preparation, reuse the intestines and stomach regulation of mental activities agent of Radix Codonopsis to chronic diarrhea, ulcerative colitis, antral gastritis, chronic atrophic gastritis etc. quite have effect.
The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.< < Bencao Beiyao > >: " lossless can sending out, has antiperspirant to stop for the Radix Astragali, life consolidating superficial resistance; Process with invigorating middle warmer beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.The just > > of < < book on Chinese herbal medicine: " Radix Astragali, soil in tonification, replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and sagging person is the most suitable for clearing heat in QI system.The through people's of its skin skin table muscle, solid protection is defended sun, enriches table minute, is its speciality, thus all diseases of exterior deficiency, the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali strengthens heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, protect the liver and fall hypoglycemic effect, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had to inhibitory action.The Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, there is spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized, cures mainly the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, QI failing to transform into body fluid, phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, and gastrointestinal function is had to regulating action.
Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.For insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, leukorrhagia.
Radix Rhodiolae: sweet, hardship, flat; Return lung, heart channel.Radix Rhodiolae is dry root and the rhizome of crassulaceae plants Radix Rhodiolae, and the effect of Radix Rhodiolae and effect are energy the kidney invigorating, regulate the flow of vital energy and nourish blood, and have promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and the effect under leukorrhagia stopping, and the side effect of Radix Rhodiolae is not temporarily found.Radix Rhodiolae can improve sleep, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyreticly bring down a fever, nourish the effects such as vigour; Be used for the treatment of traumatic injury and burn and scald outward.
Fructus Broussonetiae: sweet, cold.Enter liver, spleen, kidney channel.< < Japan hanako materia medica > >: " tonify deficiency labor, helps waist knee joint, beneficial color for strengthening bone and muscle, aid yang qi." < < your name book on Chinese herbal medicine > >: " strengthening bone and muscle, aid yang qi, tonify deficiency labor, help waist knee joint, beneficial color." the kidney invigorating liver heat removing, improving eyesight, diuresis.For soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, the dizzy blurred vision of sand, the raw nebula film of order, edema distension.Fructus Broussonetiae, book speech sweet in the mouth gas is cold, though have benefit in all dirty cloudy blood.This color profit, muscles and bones is strong, waist knee joint is strong, muscle fills, edema disappears, so that impotence rises, yang-energy helps, and is that a little less than its positive prosperous the moon of bright finger, obtaining this cloudy blood has benefit, therefore can make sun be unequal to, helps, non-Yunyang flaccidity is because sun declines, obtaining this can be also supporing yang.
Radix Salviae Miltiorrhizae: hardship, is slightly cold.GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, and promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Rhizoma Polygonati Odorati: sweet in the mouth, property is flat; Attach to the lung and stomach meridians.< < property of medicine opinion > >: " disease cold and heat when main, interior tonifying for the deficiency, removes asthenia exopathogenic heat, and headache is uneasy, adds and good with it." < < Japan hanako materia medica > >: " and except unhappy, quench the thirst, profit cardiopulmonary, mend five kinds of strain and seven kinds of impairment, deficient, waist foot pain, and it row is fanatical." < < Compendium of Materia Medica > >: " and main air temperature spontaneous perspiration is scorching hot, and malaria with general debility cold and heat, and taste void is weary, man's frequent micturition, and consumption of essence, all are deficient." Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moisten, and is the good medicine of YIN nourishing and the production of body fluid promoting simply.
Fructus Jujubae: sweet, temperature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Radix Adenophorae: sweet in the mouth, micro-hardship, cold nature, enters lung, stomach warp.Clearing away heat and nourishing YIN, has nourishing the lung to arrest cough, and the effect of nourishing the stomach to promote the production of body fluid is mainly used in lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, chronic cough expectorant blood, deficiency of stomach-Yin, mouthfeel parched throat, tracheitis, pertussis, cough due to lung-heat, the cards such as Huang is thick, constipation, the few tongue of red tongue of coughing up phlegm.
Rhizoma Zingiberis Recens: pungent, tepor.Return lung, spleen, stomach warp.Function cures mainly: the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm cough.
Margarita powder: sweet, salty, cold.GUIXIN, Liver Channel.Function cures mainly: the arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation.The insomnia that is used for palpitating with fear, infantile convulsion epilepsy, the raw nebula of order, skin infection is not held back.
The Fructus Kochiae: cold in nature, acrid in the mouth, hardship; Enter kidney, urinary bladder channel.< < property of medicine opinion > >: " with clothes, main husband's impotence does not rise with Actinolitum, QI invigorating benefit power; Control cloudy ovum Huang disease, the wind that reduces phlegm and internal heat, can make soup and take a shower." < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " sharp bladder urine accumulated heat, washes the wind of skin, treats married woman all through exopathogenic heat, clear sharp fetal heat in pregnancy, damp-heat vaginal discharge." clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Rhizoma Dioscoreae Septemlobae: property is flat, bitter in the mouth; Enter Liver Channel, stomach warp, urinary bladder channel.< < property of medicine opinion > >: " control cold wind insensitive impediment, waist foot is not pulled by, brothers are frightened, and main man's lumbago is cold for a long time, is to have bladder retained water between kidney." < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " control wind and cold, warming the meridian network, waist knee joint pain, stupid fiber crops all over, sharp wing dehydration channel, red white turbid urine." function dampness removing goes turbidly, blood stasis dispelling dispels the wind.Dampness removing goes turbid, wind expelling stagnation removing.For stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain.Dioscin or dioscorea sapotoxin in Shan Rhizoma Dioscoreae Septemlobae rhizome kill insecticide effect, and dioscin, a carat plug woods glycoside still have antifungic action.
Herba Hyperici Japonici: bitter in the mouth, flat; Return liver, gallbladder meridian.The standby > > that wants of the < < SHENGCAO property of medicine: " control wine disease, subside a swelling swollen, apply large malignant boil, reason chancre is swollen." the < < south of the Five Ridges record > > that gathers medicinal herbs: " remove the yellow fire-toxin of nitre, apply shrimp pincers skin ulcer, reason traumatic injury, snakebite." dampness removing jaundice eliminating, heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Control infectious hepatitis, dysentery, infantile convulsion, infantile malnutrition, throat moth, acute appendicitis, furuncle and phyma, venom.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each crude drug is: Radix Codonopsis 5-12 weight portion, Radix Astragali 10-30 weight portion, Rhizoma Atractylodis Macrocephalae 12-26 weight portion, Rhizoma Dioscoreae 10-27 weight portion, Herba Schizonepetae 10-25 weight portion, Folium piperis betlis 14-22 weight portion, Herba Dendrobii 15-30 weight portion, Ramulus et Folium Tamaricis 5-11 weight portion, Tremella 10-25 weight portion, Flos Lonicerae 12-36 weight portion, Fructus Viticis 14-26 weight portion, Rhizoma Polygonati 10-24 weight portion, Radix Trichosanthis 12-25 weight portion, Herba Lophatheri 14-25 weight portion, Radix Sophorae Flavescentis 4-12 weight portion, Semen Cuscutae 5-12 weight portion, Herba Senecionis Argunensis 15-28 weight portion, Radix et Rhizoma Thalictri 10-32 weight portion, Polyporus 4-10 weight portion, Radix Gentianae 15-34 weight portion, Radix Rhodiolae 15-32 weight portion, Fructus Broussonetiae 10-25 weight portion, Radix Salviae Miltiorrhizae 12-35 weight portion, Rhizoma Polygonati Odorati 15-25 weight portion, Fructus Jujubae 15-30 weight portion, Radix Adenophorae 12-25 weight portion, Rhizoma Zingiberis Recens 10-28 weight portion, Margarita powder 12-35 weight portion, Fructus Kochiae 15-34 weight portion, Rhizoma Dioscoreae Septemlobae 12-28 weight portion and Herba Hyperici Japonici 10-32 weight portion.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each crude drug can be: Radix Codonopsis 5-8 weight portion, Radix Astragali 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 12-16 weight portion, Rhizoma Dioscoreae 10-17 weight portion, Herba Schizonepetae 15-25 weight portion, Folium piperis betlis 18-22 weight portion, Herba Dendrobii 15-20 weight portion, Ramulus et Folium Tamaricis 5-9 weight portion, Tremella 10-15 weight portion, Flos Lonicerae 12-16 weight portion, Fructus Viticis 20-26 weight portion, Rhizoma Polygonati 10-14 weight portion, Radix Trichosanthis 12-15 weight portion, Herba Lophatheri 14-18 weight portion, Radix Sophorae Flavescentis 4-7 weight portion, Semen Cuscutae 5-7 weight portion, Herba Senecionis Argunensis 15-20 weight portion, Radix et Rhizoma Thalictri 20-32 weight portion, Polyporus 4-16 weight portion, Radix Gentianae 15-24 weight portion, Radix Rhodiolae 15-22 weight portion, Fructus Broussonetiae 10-15 weight portion, Radix Salviae Miltiorrhizae 22-35 weight portion, Rhizoma Polygonati Odorati 15-20 weight portion, Fructus Jujubae 15-20 weight portion, Radix Adenophorae 20-25 weight portion, Rhizoma Zingiberis Recens 10-18 weight portion, Margarita powder 22-35 weight portion, Fructus Kochiae 25-34 weight portion, Rhizoma Dioscoreae Septemlobae 12-18 weight portion and Herba Hyperici Japonici 20-32 weight portion.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each crude drug can be: Radix Codonopsis 7 weight portions, the Radix Astragali 20 weight portions, the Rhizoma Atractylodis Macrocephalae 16 weight portions, Rhizoma Dioscoreae 17 weight portions, Herba Schizonepetae 15 weight portions, Folium piperis betlis 14 weight portions, Herba Dendrobii 30 weight portions, Ramulus et Folium Tamaricis 5 weight portions, Tremella 15 weight portions, Flos Lonicerae 16 weight portions, Fructus Viticis 20 weight portions, Rhizoma Polygonati 14 weight portions, Radix Trichosanthis 15 weight portions, Herba Lophatheri 18 weight portions, Radix Sophorae Flavescentis 5 weight portions, Semen Cuscutae 6 weight portions, Herba Senecionis Argunensis 18 weight portions, Radix et Rhizoma Thalictri 22 weight portions, Polyporus 6 weight portions, Radix Gentianae 24 weight portions, Radix Rhodiolae 22 weight portions, Fructus Broussonetiae 15 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Rhizoma Polygonati Odorati 20 weight portions, Fructus Jujubae 20 weight portions, Radix Adenophorae 15 weight portions, Rhizoma Zingiberis Recens 18 weight portions, Margarita powder 25 weight portions, the Fructus Kochiae 24 weight portions, Rhizoma Dioscoreae Septemlobae 18 weight portions and Herba Hyperici Japonici 22 weight portions.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each crude drug can be: Radix Codonopsis 5 weight portions, the Radix Astragali 20 weight portions, the Rhizoma Atractylodis Macrocephalae 25 weight portions, Rhizoma Dioscoreae 20 weight portions, Herba Schizonepetae 16 weight portions, Folium piperis betlis 15 weight portions, Herba Dendrobii 22 weight portions, Ramulus et Folium Tamaricis 5 weight portions, Tremella 15 weight portions, Flos Lonicerae 14 weight portions, Fructus Viticis 20 weight portions, Rhizoma Polygonati 15 weight portions, Radix Trichosanthis 22 weight portions, Herba Lophatheri 15 weight portions, Radix Sophorae Flavescentis 5 weight portions, Semen Cuscutae 5 weight portions, Herba Senecionis Argunensis 20 weight portions, Radix et Rhizoma Thalictri 25 weight portions, Polyporus 4 weight portions, Radix Gentianae 20 weight portions, Radix Rhodiolae 20 weight portions, Fructus Broussonetiae 15 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Rhizoma Polygonati Odorati 20 weight portions, Fructus Jujubae 25 weight portions, Radix Adenophorae 12 weight portions, Rhizoma Zingiberis Recens 10 weight portions, Margarita powder 12 weight portions, the Fructus Kochiae 15 weight portions, Rhizoma Dioscoreae Septemlobae 12 weight portions and Herba Hyperici Japonici 15 weight portions.
Wherein, when the dosage form of described Chinese medicine composition is patch, its preparation method is:
A. get in the ethanol that raw medicinal material Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, the Fructus Kochiae He Rhizoma Dioscoreae Septemlobae add the 80-95% that 2-3 doubly measures in proportion, heating and refluxing extraction 2 times, each 30-50 minute, filtration obtains medicinal residues and extracting solution, and extracted twice liquid is merged into the first extracting solution;
B. more above-mentioned medicinal residues and surplus stock Yao Cai Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens, Margarita powder and Herba Hyperici Japonici are added in proportion to the water heating and refluxing extraction 2 times that 2-5 doubly measures; each 30-50 minute, merge extractive liquid, obtains the second extracting solution;
C. the first extracting solution and the second extracting solution are merged, in the extracting solution suction concentrating under reduced pressure tank after merging, be decompressed to 0.05-0.10MPa, the extractum that while being concentrated into temperature to 67 ℃-81 ℃, relative density is 1.21; Heating is concentrated into pasty state, with wine, vinegar, Mel, is in harmonious proportion and spreads on skin lesion place, pastes medicine part and need clean, and with preservative film, medical adhesive tape, fixes.
Wherein, the dosage form of described Chinese medicine composition is liniment, and its preparation method is:
The first step: medical material Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, Fructus Kochiae, Rhizoma Dioscoreae Septemlobae are put into soak with ethanol 15-25 minute in proportion, post-heating temperature is 79-81 ℃ to be extracted 2 times, each 15-25 minute; Ethanol used be medical material gross weight doubly measure 1-3 doubly, concentration is 85-93%; The concentrated ethanol extract of heating, the concentrated solution that when being concentrated into temperature and being 85-90 ℃, relative density is 1.02, stand for standby use;
Second step: Yuan Liao Yao Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens, Margarita powder, Herba Hyperici Japonici described in all the other are mixed by proportioning, drop into pulverizer and be ground into fine powder, fine powder sieves after 100-150 order and puts into acid and alkali-resistance infusion kettle, at normal temperatures and pressures, the ethanol that is 85-93% with concentration floods 10-20 days jointly, squeeze, after isolated by filtration, get filtrate;
The 3rd step: described filtrate and described concentrated solution is mixed; Described mixed liquid heating is concentrated into pasty state, puts into after baking oven 78-89 ℃ oven dry coolingly, mix vaseline and make liniment.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 patch of the present invention
Radix Codonopsis 70g, Radix Astragali 200g, Rhizoma Atractylodis Macrocephalae 160g, Rhizoma Dioscoreae 170g, Herba Schizonepetae 150g, Folium piperis betlis 140g, Herba Dendrobii 300g, Ramulus et Folium Tamaricis 50g, Tremella 150g, Flos Lonicerae 160g, Fructus Viticis 200g, Rhizoma Polygonati 140g, Radix Trichosanthis 150g, Herba Lophatheri 180g, Radix Sophorae Flavescentis 50g, Semen Cuscutae 60g, Herba Senecionis Argunensis 180g, Radix et Rhizoma Thalictri 220g, Polyporus 60g, Radix Gentianae 240g, Radix Rhodiolae 220g, Fructus Broussonetiae 150g, Radix Salviae Miltiorrhizae 250g, Rhizoma Polygonati Odorati 200g, Fructus Jujubae 200g, Radix Adenophorae 150g, Rhizoma Zingiberis Recens 180g, Margarita powder 70g, Fructus Kochiae 240g, Rhizoma Dioscoreae Septemlobae 180g and Herba Hyperici Japonici 220g.
Its preparation method is:
A. get in proportion raw medicinal material Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, the Fructus Kochiae He Rhizoma Dioscoreae Septemlobae, add in 90% ethanol of 2 times of amounts, heating and refluxing extraction 2 times, each 40 minutes, filtration obtains medicinal residues and extracting solution, and extracted twice liquid is merged into the first extracting solution;
B. the water heating and refluxing extraction 2 times that more above-mentioned medicinal residues and surplus stock Yao Cai Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens and Herba Hyperici Japonici is added in proportion to 3 times of amounts; each 40 minutes, merge extractive liquid, obtained the second extracting solution;
C. the first extracting solution and the second extracting solution are merged, in the extracting solution suction concentrating under reduced pressure tank after merging, be decompressed to 0.08MPa, the extractum that while being concentrated into temperature to 72 ℃, relative density is 1.21; Heating is concentrated into pasty state, with wine, vinegar, Mel and described Margarita powder, is in harmonious proportion and spreads on skin lesion place, pastes medicine part and need clean, and with preservative film, medical adhesive tape, fixes.
Embodiment 2 liniment of the present invention
Radix Codonopsis 50g, Radix Astragali 200g, Rhizoma Atractylodis Macrocephalae 250g, Rhizoma Dioscoreae 200g, Herba Schizonepetae 160g, Folium piperis betlis 150g, Herba Dendrobii 220g, Ramulus et Folium Tamaricis 50g, Tremella 150g, Flos Lonicerae 140g, Fructus Viticis 200g, Rhizoma Polygonati 150g, Radix Trichosanthis 220g, Herba Lophatheri 150g, Radix Sophorae Flavescentis 50g, Semen Cuscutae 50g, Herba Senecionis Argunensis 200g, Radix et Rhizoma Thalictri 250g, Polyporus 40g, Radix Gentianae 200g, Radix Rhodiolae 200g, Fructus Broussonetiae 150g, Radix Salviae Miltiorrhizae 250g, Rhizoma Polygonati Odorati 200g, Fructus Jujubae 250g, Radix Adenophorae 120g, Rhizoma Zingiberis Recens 100g, Margarita powder 50g, Fructus Kochiae 150g, Rhizoma Dioscoreae Septemlobae 120g and Herba Hyperici Japonici 150g.
Its preparation method is:
The first step: get in proportion crude drug Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, the mixing of Fructus Kochiae, Rhizoma Dioscoreae Septemlobae, put into 90% ethanol of 2 times of amounts of mixture, soak 20 minutes, then heating extraction is 2 times, each 20 minutes; The concentrated ethanol extract of heating, the concentrated solution that when being concentrated into temperature and being 85 ℃, relative density is 1.02, stand for standby use;
Second step: Yuan Liao Yao Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens, Margarita powder, Herba Hyperici Japonici described in all the other are mixed by proportioning, drop into pulverizer and be ground into fine powder, fine powder sieves after 120 orders and puts into acid and alkali-resistance infusion kettle, at normal temperatures and pressures, the ethanol that is 90% with concentration floods 15 days jointly, squeeze, after isolated by filtration, get filtrate;
The 3rd step: described filtrate and described concentrated solution is mixed; Described mixed liquid heating is concentrated into pasty state, puts into after baking oven 78-89 ℃ oven dry coolingly, be ground into powder and mix vaseline and make liniment.
Embodiment 3 spray of the present invention
Radix Codonopsis 80g, Radix Astragali 200g, Rhizoma Atractylodis Macrocephalae 160g, Rhizoma Dioscoreae 170g, Herba Schizonepetae 250g, Folium piperis betlis 220g, Herba Dendrobii 200g, Ramulus et Folium Tamaricis 90g, Tremella 150g, Flos Lonicerae 160g, Fructus Viticis 260g, Rhizoma Polygonati 140g, Radix Trichosanthis 150g, Herba Lophatheri 180g, Radix Sophorae Flavescentis 70g, Semen Cuscutae 70g, Herba Senecionis Argunensis 1200g, Radix et Rhizoma Thalictri 320g, Polyporus 160g, Radix Gentianae 240g, Radix Rhodiolae 220g, Fructus Broussonetiae 150g, Radix Salviae Miltiorrhizae 350g, Rhizoma Polygonati Odorati 200g, Fructus Jujubae 200g, Radix Adenophorae 250g, Rhizoma Zingiberis Recens 180g, Margarita powder 50g, Fructus Kochiae 340g, Rhizoma Dioscoreae Septemlobae 180g and Herba Hyperici Japonici 320g.
Its preparation method is:
A, get the water extraction 2 times that Yuan Liao Yao Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens, Margarita powder, Herba Hyperici Japonici add 3 times, each 45 minutes, filtration obtains extracting solution heating and is condensed into extractum shape, is component 1;
B, medicinal residues and surplus stock medicine Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, the Fructus Kochiae, Rhizoma Dioscoreae Septemlobae can add medicinal residues 80% soak with ethanol 20 minutes, extract twice, each 15 minutes, merge extractive liquid, filter, concentrated, 130 orders filter, 6100 revs/min of supernatant after centrifugal, it through the molecular weight that dams, is 5800 ultrafiltration post ultrafiltration, 1.25 extractum when ultrafiltrate concentrating under reduced pressure relative density is 85 ℃, heating and refluxing extraction 2 times, each 20 minutes, extract active ingredient, 2 extracting solution are merged and are settled into extractum shape, as component 2,
C, component 1 and component 2 merged, add the distilled water of 3 times to mix, add the adjuvants such as 1/10th sodium sodium chloride with respect to mixture quality, sorbic acid, make spray.
Toxicity test
Acute dermal toxicity experiment
The test method(s) of once limiting the quantity of, 30 of SD rats, male and female half and half, body weight 90g~180g, back wool is proposed, with entering to be divided into 15 of 15 of experimental grouies and matched groups, the patch that the embodiment of the present invention 1 is obtained, one time percutaneous is smeared 5000mg/kg body weight dosage, observe 15 days, experimental group is not found obvious poisoning symptom, nothing death, and animal gross anatomy no abnormality seen, judges that Chinese medicine composition of the present invention is nontoxic through skin test.
Acute skin irritation test
Get male 8 of Japan large ear rabbit, body weight 2kg~3kg, according to the method for above-mentioned " acute dermal toxicity test ", the liniment 0.5g of the embodiment of the present invention 2 is directly spread upon to animal left side to be shaved (opposite side in contrast) on the skin after defeathering, adopt blocking test, administration time 4 hours, after off-test, use the residual tested material of warm water washing, after removing tested material, 1h, 12h, 24h, 48h and 72h observe respectively the dermoreaction of the tested district of animal and check plot, both sides skin all, without abnormal, judges that Chinese medicine composition of the present invention is to animal skin nonirritant.
Hypersensitive test:
Get 20 of healthy albino guinea-pigs, body weight 250-300g, male and female dual-purpose, rejects both sides dorsal body setae before test, and every side 3 * 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.Get the spray of the embodiment of the present invention 3 in unhairing district, back, every day 1 time, totally 3 times.In last, contact latter 14 days, at back the same area spray this product 0.1g, at once observe after removing medicine after 6h, and in 12,24,48,72h observes and has or not anaphylaxis.Blank group is used same method to excite with positive controls and is contacted and observe.Result of the test: localized erythema and slight edema appear in positive controls animal skin after 1 hour in sensitization, within 24 hours, symptoms of allergic increases the weight of, and there is scleroma to form, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.Judgement, Chinese medicine composition of the present invention does not have sensitization.
 
Clinical trial
Case selection: fetch and come from 150 examples that the court accumulates malicious decomposed type decubital ulcer patient, male 70 people, female 80 people; 36~75 years old age, medical history 2 months~6 months; Patient's 50 examples once, two degree patient 60 examples, three degree patient 40 examples.150 routine patients are divided into treatment by Chinese herbs group and Chinese patent medicine matched group at random, treatment by Chinese herbs group 75 people, male 34 people, female 41 people; Chinese patent medicine matched group 75 people, male 36 people, female 39 people.
Diagnostic criteria:
1. be more common in the long-term bedridden patients such as paraplegia, chronic expendable illness, large-area burns and degree of depth stupor.2. be mainly in the bone knuckle places such as rumpbone, ischial tuberosity.3. at continuous compression position, there is erythema, blister, ulcer trilogy pathological change.
Go into a coma and paralytic, be unable to leave the bed, the patient who has bad physiques, after fracture, the long-term patient who fixes or lie in bed, betides skeleton projection pressurized position, once: part only shows as erythema edema, or pale asphyxia, and cinerous, boundary is clear, has feeling of numbness or tenderness; Two degree: then skin color is darkviolet or atropurpureus, can occur vesicle, forms the rotten to the corn face of shallow table after bleb wall breaks; Three degree: ulcer, shallow person reaches subcutaneous tissue, and dark person can reach osseous tissue, diagnosable.
Therapeutic Method:
Treatment by Chinese herbs group: this organizes 75 people, is used the patch of the embodiment of the present invention 1 to treat.Every day 2 times, patch is affixed on to wound surface at every turn.Within 10 days, be a course for the treatment of, treatment is carried out 2 courses for the treatment of.Follow up a case by regular visits to half a year.
Western medicine group: this organizes 75 people, is used Benzagel to treat.Every day 2 times, be applied in wound surface.Within 10 days, be a course for the treatment of, treatment is carried out 2 courses for the treatment of.Follow up a case by regular visits to half a year.
The standard of curative effect evaluation:
Recovery from illness: heal completely through treatment wound surface.Effective: after treatment, wound surface dwindles obviously, there is more granulation growth.Take a turn for the better: through treatment wound surface, rot to organize and remove, secretions reduces.Invalid: before and after treatment, wound surface is unchanged.
Therapeutic outcome:
The efficacy result contrast that table 1 is treatment by Chinese herbs group and western medicine group
As can be seen from Table 1, therefore the recovery from illness number for the treatment of by Chinese herbs group, effective number and improvement number all will, can be learnt higher than western medicine group, Chinese medicine composition of the present invention, and in treatment decubital ulcer, good effect, determined curative effect, effective percentage is high.
The recovery from illness that table 2 is treatment by Chinese herbs group and western medicine group, time effective and that take a turn for the better contrast:
Group Number of cases The 1st course for the treatment of The 2nd course for the treatment of
Treatment by Chinese herbs group 75 50(66.67%) 25 (33.33%)
Western medicine group 63 20 (31.75%) ?43(68.25%)
As can be seen from Table 2, the recovery from illness for the treatment of by Chinese herbs group, effectively comparing with western medicine group with improvement, just can there is curative effect in the short time.Can learn, Chinese medicine composition of the present invention, in treatment decubital ulcer, curative effect is fast, rapid-action, and treatment time is shorter.
The recurrence contrast that table 3 is the recovery from illness for the treatment of by Chinese herbs group and western medicine group::
Group Recovery from illness Recurrence number Relapse rate
Treatment by Chinese herbs group 68 0 0%
Western medicine group 50 10 20%
As can be seen from Table 3, after the recovery from illness for the treatment of by Chinese herbs group, compare with western medicine group, recurrence number is few, and relapse rate is low.Can learn, Chinese medicine composition of the present invention, in treatment decubital ulcer, good effect, is difficult for recurrence.
To sum up learn, Chinese medicine composition of the present invention is being treated in decubital ulcer, good effect, and determined curative effect, rapid-action, be difficult for recurrence.
Model case: Liu, male, 50 years old, to suffer from decubital ulcer and have half a year, skin color is darkviolet or atropurpureus, occurs vesicle, forms the rotten to the corn face of shallow table after bleb wall breaks, and is decubital ulcer two degree after diagnosing.Take the spray of Chinese medicine preparation embodiment 3 of the present invention, every day 2 times, the spray 5g crude drug metering of each 0.5g/ml, 10 days is a course for the treatment of, treats 2 recoveries from illness course for the treatment of, and no side effects in treatment, follows up a case by regular visits to and do not recur half a year.
 
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (10)

1. the Chinese medicine composition of malicious decomposed type decubital ulcer is accumulate in a treatment, it is characterized in that, described Chinese medicine composition comprises following crude drug: Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Herba Schizonepetae, Folium piperis betlis, Herba Dendrobii, Ramulus et Folium Tamaricis, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Radix Sophorae Flavescentis, Semen Cuscutae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, Radix Rhodiolae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens, Margarita powder, Fructus Kochiae, Rhizoma Dioscoreae Septemlobae and Herba Hyperici Japonici.
2. Chinese medicine composition according to claim 1, is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each crude drug is: Radix Codonopsis 5-12 weight portion, Radix Astragali 10-30 weight portion, Rhizoma Atractylodis Macrocephalae 12-26 weight portion, Rhizoma Dioscoreae 10-27 weight portion, Herba Schizonepetae 10-25 weight portion, Folium piperis betlis 14-22 weight portion, Herba Dendrobii 15-30 weight portion, Ramulus et Folium Tamaricis 5-11 weight portion, Tremella 10-25 weight portion, Flos Lonicerae 12-36 weight portion, Fructus Viticis 14-26 weight portion, Rhizoma Polygonati 10-24 weight portion, Radix Trichosanthis 12-25 weight portion, Herba Lophatheri 14-25 weight portion, Radix Sophorae Flavescentis 4-12 weight portion, Semen Cuscutae 5-12 weight portion, Herba Senecionis Argunensis 15-28 weight portion, Radix et Rhizoma Thalictri 10-32 weight portion, Polyporus 4-10 weight portion, Radix Gentianae 15-34 weight portion, Radix Rhodiolae 15-32 weight portion, Fructus Broussonetiae 10-25 weight portion, Radix Salviae Miltiorrhizae 12-35 weight portion, Rhizoma Polygonati Odorati 15-25 weight portion, Fructus Jujubae 15-30 weight portion, Radix Adenophorae 12-25 weight portion, Rhizoma Zingiberis Recens 10-28 weight portion, Margarita powder 5-8 weight portion, Fructus Kochiae 15-34 weight portion, Rhizoma Dioscoreae Septemlobae 12-28 weight portion and Herba Hyperici Japonici 10-32 weight portion.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each crude drug is: Radix Codonopsis 5-8 weight portion, Radix Astragali 10-20 weight portion, Rhizoma Atractylodis Macrocephalae 12-16 weight portion, Rhizoma Dioscoreae 10-17 weight portion, Herba Schizonepetae 15-25 weight portion, Folium piperis betlis 18-22 weight portion, Herba Dendrobii 15-20 weight portion, Ramulus et Folium Tamaricis 5-9 weight portion, Tremella 10-15 weight portion, Flos Lonicerae 12-16 weight portion, Fructus Viticis 20-26 weight portion, Rhizoma Polygonati 10-14 weight portion, Radix Trichosanthis 12-15 weight portion, Herba Lophatheri 14-18 weight portion, Radix Sophorae Flavescentis 4-7 weight portion, Semen Cuscutae 5-7 weight portion, Herba Senecionis Argunensis 15-20 weight portion, Radix et Rhizoma Thalictri 20-32 weight portion, Polyporus 4-16 weight portion, Radix Gentianae 15-24 weight portion, Radix Rhodiolae 15-22 weight portion, Fructus Broussonetiae 10-15 weight portion, Radix Salviae Miltiorrhizae 22-35 weight portion, Rhizoma Polygonati Odorati 15-20 weight portion, Fructus Jujubae 15-20 weight portion, Radix Adenophorae 20-25 weight portion, Rhizoma Zingiberis Recens 10-18 weight portion, Margarita powder 5-7 weight portion, Fructus Kochiae 25-34 weight portion, Rhizoma Dioscoreae Septemlobae 12-18 weight portion and Herba Hyperici Japonici 20-32 weight portion.
4. according to the Chinese medicine composition described in claims 1 to 3 any one, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each crude drug is: Radix Codonopsis 7 weight portions, the Radix Astragali 20 weight portions, the Rhizoma Atractylodis Macrocephalae 16 weight portions, Rhizoma Dioscoreae 17 weight portions, Herba Schizonepetae 15 weight portions, Folium piperis betlis 14 weight portions, Herba Dendrobii 30 weight portions, Ramulus et Folium Tamaricis 5 weight portions, Tremella 15 weight portions, Flos Lonicerae 16 weight portions, Fructus Viticis 20 weight portions, Rhizoma Polygonati 14 weight portions, Radix Trichosanthis 15 weight portions, Herba Lophatheri 18 weight portions, Radix Sophorae Flavescentis 5 weight portions, Semen Cuscutae 6 weight portions, Herba Senecionis Argunensis 18 weight portions, Radix et Rhizoma Thalictri 22 weight portions, Polyporus 6 weight portions, Radix Gentianae 24 weight portions, Radix Rhodiolae 22 weight portions, Fructus Broussonetiae 15 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Rhizoma Polygonati Odorati 20 weight portions, Fructus Jujubae 20 weight portions, Radix Adenophorae 15 weight portions, Rhizoma Zingiberis Recens 18 weight portions, Margarita powder 6 weight portions, the Fructus Kochiae 24 weight portions, Rhizoma Dioscoreae Septemlobae 18 weight portions and Herba Hyperici Japonici 22 weight portions.
5. according to the Chinese medicine composition described in claim 1 to 4 any one, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each crude drug is: Radix Codonopsis 5 weight portions, the Radix Astragali 20 weight portions, the Rhizoma Atractylodis Macrocephalae 25 weight portions, Rhizoma Dioscoreae 20 weight portions, Herba Schizonepetae 16 weight portions, Folium piperis betlis 15 weight portions, Herba Dendrobii 22 weight portions, Ramulus et Folium Tamaricis 5 weight portions, Tremella 15 weight portions, Flos Lonicerae 14 weight portions, Fructus Viticis 20 weight portions, Rhizoma Polygonati 15 weight portions, Radix Trichosanthis 22 weight portions, Herba Lophatheri 15 weight portions, Radix Sophorae Flavescentis 5 weight portions, Semen Cuscutae 5 weight portions, Herba Senecionis Argunensis 20 weight portions, Radix et Rhizoma Thalictri 25 weight portions, Polyporus 4 weight portions, Radix Gentianae 20 weight portions, Radix Rhodiolae 20 weight portions, Fructus Broussonetiae 15 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Rhizoma Polygonati Odorati 20 weight portions, Fructus Jujubae 25 weight portions, Radix Adenophorae 12 weight portions, Rhizoma Zingiberis Recens 10 weight portions, Margarita powder 5 weight portions, the Fructus Kochiae 15 weight portions, Rhizoma Dioscoreae Septemlobae 12 weight portions and Herba Hyperici Japonici 15 weight portions.
6. according to the Chinese medicine composition described in claim 1 to 5 any one, it is characterized in that, the dosage form of described Chinese medicine composition is patch, and its preparation method is:
A. get in proportion raw medicinal material Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, the Fructus Kochiae He Rhizoma Dioscoreae Septemlobae, add in the ethanol of the 80-95% that 2-3 doubly measures, heating and refluxing extraction 2 times, each 30-50 minute, filtration obtains medicinal residues and extracting solution, and extracted twice liquid is merged into the first extracting solution;
B. more above-mentioned medicinal residues and surplus stock Yao Cai Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens and Herba Hyperici Japonici are added in proportion to the water heating and refluxing extraction 2 times that 2-5 doubly measures; each 30-50 minute, merge extractive liquid, obtains the second extracting solution;
C. the first extracting solution and the second extracting solution are merged, in the extracting solution suction concentrating under reduced pressure tank after merging, be decompressed to 0.05-0.10MPa, the extractum that while being concentrated into temperature to 67 ℃-81 ℃, relative density is 1.21; Heating is concentrated into pasty state, with wine, vinegar, Mel and described Margarita powder, is in harmonious proportion and spreads on skin lesion place, pastes medicine part and need clean, and with preservative film, medical adhesive tape, fixes.
7. according to the Chinese medicine composition described in claim 1 to 5 any one, it is characterized in that, the dosage form of described Chinese medicine composition is liniment, and its preparation method is:
The first step: get in proportion crude drug Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, the mixing of Fructus Kochiae, Rhizoma Dioscoreae Septemlobae, put into the 80-95% ethanol that mixture 1-3 doubly measures, soak 15-25 minute, then heating extraction is 2 times, each 15-25 minute; The concentrated ethanol extract of heating, the concentrated solution that when being concentrated into temperature and being 85-90 ℃, relative density is 1.02, stand for standby use;
Second step: Yuan Liao Yao Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens, Margarita powder, Herba Hyperici Japonici described in all the other are mixed by proportioning, drop into pulverizer and be ground into fine powder, fine powder sieves after 100-150 order and puts into acid and alkali-resistance infusion kettle, at normal temperatures and pressures, the ethanol that is 85-93% with concentration floods 10-20 days jointly, squeeze, after isolated by filtration, get filtrate;
The 3rd step: described filtrate and described concentrated solution is mixed; Described mixed liquid heating is concentrated into pasty state, puts into after baking oven 78-89 ℃ oven dry coolingly, be ground into powder and mix vaseline and make liniment.
8. a preparation method for the Chinese medicine composition described in claim 1 to 5 any one, is characterized in that, the dosage form of described Chinese medicine composition is patch, and its preparation method is:
A. get in proportion raw medicinal material Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, the Fructus Kochiae He Rhizoma Dioscoreae Septemlobae, add in the ethanol of the 80-95% that 2-3 doubly measures, heating and refluxing extraction 2 times, each 30-50 minute, filtration obtains medicinal residues and extracting solution, and extracted twice liquid is merged into the first extracting solution;
B. more above-mentioned medicinal residues and surplus stock Yao Cai Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens and Herba Hyperici Japonici are added in proportion to the water heating and refluxing extraction 2 times that 2-5 doubly measures; each 30-50 minute, merge extractive liquid, obtains the second extracting solution;
C. the first extracting solution and the second extracting solution are merged, in the extracting solution suction concentrating under reduced pressure tank after merging, be decompressed to 0.05-0.10MPa, the extractum that while being concentrated into temperature to 67 ℃-81 ℃, relative density is 1.21; Heating is concentrated into pasty state, with wine, vinegar, Mel and described Margarita powder, is in harmonious proportion and spreads on skin lesion place, pastes medicine part and need clean, and with preservative film, medical adhesive tape, fixes.
9. a preparation method for the Chinese medicine composition described in claim 1 to 5 any one, is characterized in that, the dosage form of described Chinese medicine composition is liniment, and its preparation method is:
The first step: get in proportion crude drug Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Schizonepetae, Ramulus et Folium Tamaricis, Radix Sophorae Flavescentis, Rhizoma Dioscoreae, Radix Rhodiolae, Herba Senecionis Argunensis, Radix et Rhizoma Thalictri, Polyporus, Radix Gentianae, the mixing of Fructus Kochiae, Rhizoma Dioscoreae Septemlobae, put into the 80-95% ethanol that mixture 1-3 doubly measures, soak 15-25 minute, then heating extraction is 2 times, each 15-25 minute; The concentrated ethanol extract of heating, the concentrated solution that when being concentrated into temperature and being 85-90 ℃, relative density is 1.02, stand for standby use;
Second step: Yuan Liao Yao Folium piperis betlis, Herba Dendrobii, Tremella, Flos Lonicerae, Fructus Viticis, Rhizoma Polygonati, Radix Trichosanthis, Herba Lophatheri, Semen Cuscutae, Fructus Broussonetiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati Odorati, Fructus Jujubae, Radix Adenophorae, Rhizoma Zingiberis Recens, Margarita powder, Herba Hyperici Japonici described in all the other are mixed by proportioning, drop into pulverizer and be ground into fine powder, fine powder sieves after 100-150 order and puts into acid and alkali-resistance infusion kettle, at normal temperatures and pressures, the ethanol that is 85-93% with concentration floods 10-20 days jointly, squeeze, after isolated by filtration, get filtrate;
The 3rd step: described filtrate and described concentrated solution is mixed; Described mixed liquid heating is concentrated into pasty state, puts into after baking oven 78-89 ℃ oven dry coolingly, be ground into powder and mix vaseline and make liniment.
10. according to the Chinese medicine composition described in claim 1 to 5 any one, it is characterized in that, the dosage form of described Chinese medicine composition is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, liniment, enema and patch.
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CN105125724A (en) * 2015-10-16 2015-12-09 青岛云天生物技术有限公司 Traditional Chinese medicine combination for treating accumulated toxin decaying type bedsores
CN105193770A (en) * 2015-09-17 2015-12-30 陈红 Liniment for treating deep bedsores combined with bone infection and preparation method of liniment

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CN105125724A (en) * 2015-10-16 2015-12-09 青岛云天生物技术有限公司 Traditional Chinese medicine combination for treating accumulated toxin decaying type bedsores

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