CN102861272B - Preparation method of traditional Chinese medicine wet issue for treating urticaria papulosa - Google Patents
Preparation method of traditional Chinese medicine wet issue for treating urticaria papulosa Download PDFInfo
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Abstract
The invention discloses a preparation method of traditional Chinese medicine wet issue for treating urticaria papulosa. The preparation method comprises the steps of taking golden cypress, radix sophorae flavescentis, honeysuckle, rhizoma smilacis glabrae, fructus kochiae, lithospermum purpurocaeruleum and cortex dictamni as the main raw materials, and preparing into the traditional Chinese medicine wet issue through traditional preparation technology. The traditional Chinese medicine wet issue prepared by the preparation method disclosed by the invention has the function of clearing away heat and toxic materials, promoting diuresis and relieving itching, and has the characteristics of being no pain, easy to accept, and obvious in treatment effect; and locally known traditional Chinese medicines are used as the raw materials, which are low in cost, and have obvious treatment effect.
Description
Technical field
The present invention relates to Chinese medicine field, particularly a kind of preparation method for the treatment of the Chinese medicine wet tissue of papular urticaria.
Background technology
Urticaria is commonly called as welt, rubella group, wind pimple, rubella wheal, is a kind of common dermatosis.By various factors, causing mucocutaneous blood vessel that temporary inflammatory hyperemia occurs oozes out with large quantity of fluid.Cause the infringement of local edema.It occurs rapidly and disappears, has play to itch.The common cause of disease has medicine, food, inhalation (inhalatio), infection, physical factor, mosquito bite, Nervous and Mental Factors etc.The pathogeny of urticaria is not yet completely clear, main at present
Divide immunity and non-immunity two classes.This disease of western medical treatment is mainly antiallergic and symptomatic treatment at present.For acute urticaria, conventional antihistaminic, vitamin C, calcium preparation etc. reduce vascular permeability.For chronic urticaria, take antihistaminic treatment as main, also useful antifibrinolysin medicine, histaglobin, press down skin enzyme, chlorination caye beautiful jade, carbazochrome salicylate, reserpine etc.But Western medicine curative effect does not significantly exist untoward reaction more, and after drug withdrawal, be easy to recurrence.
Papular urticaria claims again lichen urticatus, strophulus or children's's lichen urticatus, acute simplex prurigo, is the common anaphylaxis dermatosis of infant.Clinical characters is the pimple that being dispersed in property, character are slightly hard, there is phlycten on top, and periphery has spindle blush, conscious pruritus.The common cause of disease is mainly the anaphylaxis causing after being bitten by mosquito, Cimex bedbug, flea, louse, demodicid mite, midge etc., and insecticide is thrust skin by its mouthpart and suckes blood, and its saliva and the residual Intradermal of part mouthpart are the reasons that causes that this is sick.Its typical skin lesion is Semen phaseoli radiati or slightly large pale red pimple, and character is hard, and often there is phlycten on top, and after scratching brokenly, incrustation, has spindle blush around, presents welt after scratching, and after welt disappears, still resiles.This disease of western medical treatment is mainly hydryllin for oral administration, vitamin C at present, and the various anti-itching lotions of external, as 1%～2% carbolic acid Calamine Lotion, compound recipe Alumen lotion, dyclonine Emulsion and various corticosteroid hormone Emulsions etc.Equally, doctor trained in Western medicine easily makes patient produce drug dependence in treatment papular urticaria process, and easily recurrence.
The traditional Chinese medical science is particular about dialectical treating in treatment papular urticaria process, according to patient's different situations, carries out dialectical treatment, can allow like this patient start with and treat from the cause of disease, obtains the effect of good symptomatic treatment.Publication number CN 102327448 A(application numbers 201110275222. 0) Chinese patent literature discloses a kind of Chinese herbal medicine for the treatment of urticaria, Radix Angelicae Sinensis 25-35 part, Radix Rehmanniae 35-45 part, Periostracum Cicadae 15-25 part, Rhizoma Anemarrhenae 25-35 part, Radix Sophorae Flavescentis 25-35 part, Semen Lini 15-25 part, Herba Schizonepetae 25-35 part, Rhizoma Atractylodis 35-45 part, 25-35 part energetically, Gypsum Fibrosum 35-45 part, Radix Glycyrrhizae 15-25 part, Caulis Akebiae 25-35 part, Folium Isatidis 15-25 part, Desmodiumtrilorumrr. 15-25 part, Radix Alangii 15-25 part, Sesarma dehaani H. Milne-Edwards. 15-25 part, add 1800 parts, water, after boiled, slow fire infusion 20-30 minutes, under filtration, collect supernatant.Infusion 3 times, by high temperature sterilize after the supernatant bottling mix homogeneously boiling for 3 times, standby.It is classified as monarch to work as; Take the Radix Rehmanniae, Periostracum Cicadae is minister; Take the Rhizoma Anemarrhenae, Radix Sophorae Flavescentis, Semen Lini, Herba Schizonepetae is assistant; With Rhizoma Atractylodis, energetically, Gypsum Fibrosum, Radix Glycyrrhizae, Caulis Akebiae, Folium Isatidis, Desmodiumtrilorumrr., Radix Alangii, Sesarma dehaani H. Milne-Edwards. be for making.Publication number CN 102614454 A(application numbers 201110205663.3) Chinese patent literature discloses a kind of Chinese medicine for the treatment of urticaria, it is made through attrition process by the raw material of following portions by weight, flying worm 20-30 part, the 20-30 of Radix Et Rhizoma Rhei part, Rhizoma Curcumae Longae 20-30 part, Periostracum Cicadae 20-30 part.It claims that the present invention has dispelling wind to relieve the exterior syndrome, the function of removing dampness heat clearing away, and by this medicine treatment urticaria, the cycle of taking is short, and side effect is little, and therapeutic effect is remarkable.The Chinese patent literature of publication number CN 101721536 A (application number 200810194989.9) discloses a kind of medicine for the treatment of papular urticaria, by Radix Saposhnikoviae, Radix Arnebiae (Radix Lithospermi), the Radix Rehmanniae, Indigo Naturalis, the Radix Astragali, the Radix Paeoniae Alba, Radix Glycyrrhizae, is that raw material is made.It claims that result of use of the present invention is good, determined curative effect, and effective percentage is up to more than 90%.Publication number CN 101612253 A(application numbers 200910067318.0) Chinese patent literature discloses a kind of pharmaceutical composition that is used for the treatment of papular urticaria, belongs to Chinese medicine.Include by the active substance of following weight fraction ratio: 7 parts of cimicifugosides, 6.5 parts of Periostracum Cicadae ethanol extract, 14 parts of betanins, 8.5 parts of Rhzoma Atractylodis Lanceae volatile oils, 17 parts of Semen Lini extracts, 14 parts of Radix Angelicae Sinensis polysaccharides, 27.5 parts of Radix Rehmanniae extracts, 4.5 parts of Caulis Aristolochiae Manshuriensis extracts, 5.5 parts of Herba Schizonepetae volatile oils, 5 parts, Gypsum Fibrosum, 6 parts of glycyrrhizic acids.It claims that the present invention is used for the treatment of papular urticaria, also for eczema, skin pruritus.
The medicine of various treatment urticaria, no matter be that different curative effects all appear in Chinese medicine or Western medicine, has alleviated patient's misery greatly above, and weak point is that the medication cycle is long, easily recurrence.
Summary of the invention
For the deficiencies in the prior art, order of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine wet tissue of papular urticaria, it has heat-clearing and toxic substances removing, the antipruritic function of dampness removing, there is no pain, easily accept, feature evident in efficacy, and it adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat papular urticaria the preparation method of Chinese medicine wet tissue, it is characterized in that: with the primary raw material of following weight proportion:
15 ~ 30 parts of 40 ~ 80 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
20 ~ 30 parts of 20 ~ 40 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
10 ~ 50 parts of 15 ~ 35 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
20 ~ 40 parts of Cortex Dictamni
Each raw material is cleaned and mixed, add the water of 25 ~ 30 times of raw material weights, soak 40-90min, boil with high heat pot, use slow fire instead, keep slight boiling condition to decoct 20-40 minute, filtering residue, the nonwoven of sterilizing arranges that, in filtrate, dipping, obtains finished product wet tissue.
Foregoing preparation method, preferred scheme is: the primary raw material with following weight proportion is prepared from:
16 ~ 28 parts of 45 ~ 75 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
22 ~ 30 parts of 22 ~ 38 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
15 ~ 45 parts of 15 ~ 32 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
22 ~ 38 parts of Cortex Dictamni.
Foregoing preparation method, preferred scheme is: the primary raw material with following weight proportion is prepared from:
18 ~ 26 parts of 50 ~ 70 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
22 ~ 28 parts of 24 ~ 36 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
20 ~ 40 parts of 15 ~ 30 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
25 ~ 35 parts of Cortex Dictamni.
Foregoing preparation method, preferred scheme is: the primary raw material with following weight proportion is prepared from:
20 parts of 60 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
25 parts of 25 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
30 parts of 25 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
30 parts of Cortex Dictamni.
Foregoing preparation method, preferred scheme is: water consumption is 26-28 times (preferably 27 times) of raw material gross weight.
Foregoing preparation method, preferably scheme is, the time of immersion is 50-70 minute (preferably 60 minutes).
Foregoing preparation method, preferably scheme is, the time that keeps slight boiling condition to decoct is 25-35 minute (preferably 30 minutes).
Foregoing preparation method, preferably scheme is, described wet tissue specification is 18.5cm * 18.5cm.
This Chinese medicine wet tissue is remarkable for papular urticaria therapeutic effect, and there is no pain, easily accept, feature evident in efficacy.
The pharmacological effect that the present invention treats each crude drug of Chinese medicine wet tissue of papular urticaria is:
Cortex Phellodendri, nature and flavor: hardship, cold.Gui Jing: return kidney, urinary bladder channel.Effect: heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.Cure mainly: for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi ， flaccidity of feet with lamenness, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
Radix Sophorae Flavescentis, nature and flavor: hardship, cold.Gui Jing: GUIXIN, liver, stomach, large intestine, urinary bladder channel.Effect: heat clearing and damp drying, parasite killing, diuresis.Cure mainly: for hematodiarrhoea, have blood in stool. jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy.
Flos Lonicerae, nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, wind-heat dissipating.Cure mainly: for carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.
Rhizoma Smilacis Glabrae, nature and flavor: sweet light, flat.Gui Jing: return liver, stomach, spleen channel.Function: removing toxic substances, dehumidifying, sharp joint.Cure mainly: control syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, treats furuncle, carbuncle, scrofula, the limbs contracture due to syphilis and mercurialism, bones and muscles pain.
The Fructus Kochiae, nature and flavor: pungent, bitter, cold.Gui Jing: return kidney, urinary bladder channel.Effect: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Cure mainly: for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Radix Arnebiae (Radix Lithospermi), nature and flavor: sweet, salty, cold.Gui Jing: GUIXIN, Liver Channel.Effect: removing heat from blood, invigorate blood circulation, removing toxic substances rash.Cure mainly: for heat in blood poison, contain, class's rash purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Cortex Dictamni, nature and flavor: hardship, cold.Gui Jing: return spleen, stomach, urinary bladder channel.Effect: heat clearing and damp drying. the removing toxic substances of dispeling the wind.Cure mainly: for damp and hot sore, yellow fluid is dripping eczema, rubella, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, yellow cellulitis dark coloured urine.
The present invention is used for the treatment of the Chinese medicine wet tissue of papular urticaria, meets the traditional Chinese medical science about the theory of urticaria.For above-mentioned defect in treatment papular urticaria process, this product, summing up on the basis of forefathers' experience, is gone through clinical research for many years, adopts pure natural draft Chinese medicine unique formula and technique to refine and forms.This product includes abundant plant biological active component, can directly act on affected part.And there is no pain, easily accept, feature evident in efficacy.
Prescription analysis: Cortex Phellodendri has heat-clearing and toxic substances removing, the effect of heat clearing and damp drying, is monarch drug; Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating, is ministerial drug; Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, the Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Cortex Dictamni our heat-clearing and toxic substances removing, dampness removing are antipruritic, the effect of antiseptic and inhibiting bacteria function for assistant makes to strengthen.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1:a Chinese medicine wet tissue for papular urticaria, is prepared from (every part of 5g) with the primary raw material of following weight proportion:
30 parts of 80 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
30 parts of 40 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
50 parts of 35 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
40 parts of Cortex Dictamni.
Each raw material is cleaned and mixed, add the water of 30 times of raw material weights, soak 90min, boil with high heat pot, use slow fire instead, keep slight boiling condition to decoct 40 minutes, filtering residue, the nonwoven of sterilizing arranges that, in filtrate, dipping, obtains finished product wet tissue.
embodiment 2:treat a Chinese medicine wet tissue for papular urticaria, with the primary raw material of following weight proportion, be prepared from (every part of 10g):
15 parts of 40 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
20 parts of 20 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
10 parts of 15 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
20 parts of Cortex Dictamni.
The preparation method of described Chinese medicine wet tissue, basic identical with embodiment, but water consumption is 26 times of raw material gross weight.
embodiment 3:treat a Chinese medicine wet tissue for papular urticaria, with the primary raw material of following weight proportion, be prepared from (every part of 20g):
28 parts of 75 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
30 parts of 38 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
45 parts of 32 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
38 parts of Cortex Dictamni.
Preparation method is substantially identical with embodiment 1, but water consumption is 28 times of raw material gross weight.
embodiment 4:treat a Chinese medicine wet tissue for papular urticaria, with the primary raw material of following weight proportion, be prepared from (every part of 25g):
16 parts of 45 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
22 parts of 22 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
15 parts of 15 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
22 parts of Cortex Dictamni.
Preparation method is substantially identical with embodiment 1, but the time of soaking is 50 minutes.
embodiment 5:treat a Chinese medicine wet tissue for papular urticaria, with the primary raw material of following weight proportion, be prepared from (every part of 10g):
25 parts of 65 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
25 parts of 25 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
35 parts of 25 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
30 parts of Cortex Dictamni.
Preparation method is substantially identical with embodiment 1, but the time that keeps slight boiling condition to decoct is 35 minutes.
embodiment 6:treat a Chinese medicine wet tissue for papular urticaria, with the primary raw material of following weight proportion, be prepared from:
Cortex Phellodendri 60g Radix Sophorae Flavescentis 20g
Flos Lonicerae 25g Rhizoma Smilacis Glabrae 25g
Fructus Kochiae 25g Radix Arnebiae (Radix Lithospermi) 30g
Cortex Dictamni 30g.
Preparation method, is that each raw material is cleaned and mixed, and adds the water of 27 times of raw material weights, soaks 60min, boils with high heat pot, uses slow fire instead, keeps slight boiling condition to decoct 30 minutes.
The applicable age of the best of Chinese medicine wet tissue of the present invention: child or the child in 0-14 year, there is no pain, easily accept the feature such as evident in efficacy.Indication mainly contains: papular urticaria.The course for the treatment of: wiping affected part before sleeping every night (the first note of the person of being in a bad way applies affected part 10 minutes), 1-5 time effective, 7 days is a course for the treatment of.
clinical model case (embodiment 6 gained medicines):
Clinical case 1: Mrs's Wang daughter is large two years old 05 months this year, and in May, 2012, the large pale red pimple of Semen phaseoli radiati, appears in daughter's trunk and extremity near-end in batch, and top also has phlycten, has spindle blush around, scratches and grabs rear formation welt, and pimple is very itched.Be diagnosed as papular urticaria, at first adopt the rear symptom of the outer wiping of corticosteroid hormone ointment to alleviate, after drug withdrawal, recur.Rear use Chinese medicine wet tissue of the present invention, wiping affected part before sleeping every night, transference cure after 3 days, continue to be used a course for the treatment of of this wet tissue, consolidates recurrence so far doing.
Clinical case 2, Mr.'s Sun son Jia Jia, 10 years old, in 2011, start one and enter cheek in summer, back, medial thigh skin and occur erythra, erythra is spindle, starts as small rice grain pimple, then develop into Semen Glycines large to Semen arachidis hypogaeae, erythra is very itched, and whole body is trooped or evacuated distribution.Use Chinese medicine wet tissue of the present invention, advise it to sleep before wiping affected part.After 3 days, symptom takes a turn for the better, and after the course for the treatment of, thoroughly cures.
Clinical case 3, Miss Wu's daughter once must cross papular urticaria former years, and this year, summer has set in was had an attack of one's old illness again, at first adopted the rear symptom of the outer wiping of corticosteroid hormone ointment to alleviate, and after drug withdrawal, recurred.In in July, 2011 here medical, allow her use the Chinese medicine wet tissue of the present invention of a course for the treatment of, advise its wiping affected part before sleeping, after 5 days, erythema disappears, and continues to use this wet tissue thoroughly to cure after the course for the treatment of.
test example 1(embodiment 6 gained medicines):
The < < new Chinese medicine guideline of clinical investigations > > formulating for 1993 according to Ministry of Public Health is diagnosis basis, totally 200 example ages are at the child patient of suffering from papular urticaria between 0-14 year, wherein, boy 96 people, girl 104 people, the mean age is 3.8 years old.Random division is administration group and matched group.
The previous day before experiment, record patient's health, comprise skin surface situation, pruritus degree, erythra distribution and emotion changes (by question and answer and answer test problem, determining), look over patient body symptom every day, guarantee that administration group and matched group situation are basically identical.Administration group is used this product wiping affected part every day just before going to bed, within 7 days, is a course for the treatment of.Check patient body situation every day, make a record.Result is as following table 1:
Table 1:
Self-induction symptom and emotion changes result are as table 2:
Table 2:
efficacy analysis:when administration group (Chinese medicine wet tissue of the present invention) is used 3 days, most patient sensory symptoms obviously alleviates, and urticaria reduces, and scratchiness is no longer strong, patient's emotion takes a turn for the better, use this wet tissue in the time of 5 days patient be almost recovered, urticaria disappears, the existence of imperceptible pruritus, spiritual cephalopodium, in a good humor.Stop using a period of time to have no repeatedly, the state of an illness is better controlled.Matched group take medicine after curative effect obvious, but after stopping using, 94% patient is recurred again.
In sum, Chinese medicine wet tissue effect of the present invention is remarkable, Most patients use this wet tissue after 3 days symptom be clearly better, scratchiness disappears, comparatively severe patient use this wet tissue after 5 days symptom also can be improved significantly.
It should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (9)
- Treatment papular urticaria the preparation method of Chinese medicine wet tissue, it is characterized in that: take off the raw material of stating weight proportion:15～30 parts of 40～80 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri20～30 parts of 20～40 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae10～50 parts of 15～35 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae20～40 parts of Cortex DictamniEach raw material is cleaned and mixed, add raw material weight 26-28 water doubly, soak 50-70min, boil with high heat pot, use slow fire instead, keep slight boiling condition to decoct 20-40 minute, filtering residue, the nonwoven of sterilizing arranges that, in filtrate, dipping, obtains finished product wet tissue.
- 2. preparation method according to claim 1, is characterized in that: each raw material:16～28 parts of 45～75 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri22～30 parts of 22～38 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae15～45 parts of 15～32 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae22～38 parts of Cortex Dictamni.
- 3. preparation method according to claim 1, is characterized in that: each raw material:18～26 parts of 50～70 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri22～28 parts of 24～36 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae20～40 parts of 15～30 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae25～35 parts of Cortex Dictamni.
- 4. preparation method according to claim 1, is characterized in that: each raw material:20 parts of 60 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri25 parts of 25 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae30 parts of 25 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae30 parts of Cortex Dictamni.
- 5. preparation method according to claim 1, is characterized in that: water consumption is 27 times of raw material gross weight.
- 6. preparation method according to claim 1, is characterized in that, the time of immersion is 60 minutes.
- 7. preparation method according to claim 1, is characterized in that, the time that keeps slight boiling condition to decoct is 25-35 minute.
- 8. preparation method according to claim 7, is characterized in that, the time is 30 minutes.
- 9. preparation method according to claim 1, is characterized in that, described wet tissue specification is 18.5cm * 18.5cm.
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