The preparation method of the Chinese medicine wet tissue for the treatment of papular urticaria
Technical field
The present invention relates to the Chinese medicine field, particularly a kind of preparation method for the treatment of the Chinese medicine wet tissue of papular urticaria.
Background technology
Urticaria is commonly called as welt, rubella group, wind pimple, rubella wheal, is a kind of common dermatosis.Causing mucocutaneous blood vessel that temporary inflammatory hyperemia occurs by various factors oozes out with large quantity of fluid.Cause the infringement of local edema.It occurs rapidly and disappears, has play to itch.The common cause of disease has medicine, food, inhalation (inhalatio), infection, physical factor, mosquito bite, Nervous and Mental Factors etc.The pathogeny of urticaria is not yet fully clear, and is main at present
Divide immunity and non-immunity two classes.Western medical treatment should disease mainly be antiallergic and symptomatic treatment at present.For acute urticaria, antihistaminic commonly used, vitamin C, calcium preparation etc. reduce vascular permeability.For chronic urticaria take the antihistaminic treatment as main, also useful antifibrinolysin medicine, histaglobin, press down skin enzyme, chlorination caye beautiful jade, carbazochrome salicylate, reserpine etc.But the Western medicine curative effect does not significantly exist untoward reaction more, and is easy to recurrence after the drug withdrawal.
Papular urticaria claims again lichen urticatus, strophulus or children's's lichen urticatus, acute simplex prurigo, is the common anaphylaxis dermatosis of infant.Clinical characters is the pimple that being dispersed in property, character are slightly hard, there is phlycten on the top, and periphery has spindle blush, conscious pruritus.The common cause of disease mainly is the anaphylaxis that causes after being bitten by mosquito, Cimex bedbug, flea, louse, demodicid mite, midge etc., and insecticide is thrust skin by its mouthpart and suckes blood, and its saliva and the residual Intradermal of part mouthpart are the reasons that causes that this is sick.Its typical skin lesion is Semen phaseoli radiati or slightly large pale red pimple, and character is hard, and often there is phlycten on the top, and incrustation has spindle blush on every side after scratching brokenly, presents welt after scratching, and still resiles after welt disappears.Western medical treatment should disease mainly be hydryllin for oral administration, vitamin C at present, and the various anti-itching lotions of external are such as 1%~2% carbolic acid Calamine Lotion, compound recipe Alumen lotion, dyclonine Emulsion and various corticosteroid hormone Emulsions etc.Equally, doctor trained in Western medicine makes the patient produce drug dependence in treatment papular urticaria process easily, and easily recurrence.
The traditional Chinese medical science is particular about dialectical executing and is controlled in treatment papular urticaria process, carry out dialectical treatment according to patient's different situations, can allow like this patient start with from the cause of disease and treat, and obtains the effect of good symptomatic treatment.Publication number CN 102327448 A(application numbers 201110275222. 0) Chinese patent literature discloses a kind of Chinese herbal medicine for the treatment of urticaria, Radix Angelicae Sinensis 25-35 part, Radix Rehmanniae 35-45 part, Periostracum Cicadae 15-25 part, Rhizoma Anemarrhenae 25-35 part, Radix Sophorae Flavescentis 25-35 part, Semen Lini 15-25 part, Herba Schizonepetae 25-35 part, Rhizoma Atractylodis 35-45 part, 25-35 part energetically, Gypsum Fibrosum 35-45 part, Radix Glycyrrhizae 15-25 part, Caulis Akebiae 25-35 part, Folium Isatidis 15-25 part, Desmodiumtrilorumrr. 15-25 part, Radix Alangii 15-25 part, Sesarma dehaani H. Milne-Edwards. 15-25 part adds 1800 parts in water, boiled after, slow fire infusion 20-30 minutes collects supernatant under filtering.Infusion 3 times, with high temperature sterilize behind the supernatant bottling mix homogeneously that boils for 3 times, for subsequent use.It is classified as monarch to work as; Take the Radix Rehmanniae, Periostracum Cicadae as minister; Take the Rhizoma Anemarrhenae, Radix Sophorae Flavescentis, Semen Lini, Herba Schizonepetae as assistant; With Rhizoma Atractylodis, energetically, Gypsum Fibrosum, Radix Glycyrrhizae, Caulis Akebiae, Folium Isatidis, Desmodiumtrilorumrr., Radix Alangii, Sesarma dehaani H. Milne-Edwards. be for making.Publication number CN 102614454 A(application numbers 201110205663.3) Chinese patent literature discloses a kind of Chinese medicine for the treatment of urticaria, it is made through attrition process by the raw material of following portions by weight, flying worm 20-30 part, the 20-30 of Radix Et Rhizoma Rhei part, Rhizoma Curcumae Longae 20-30 part, Periostracum Cicadae 20-30 part.It claims that the present invention has dispelling wind to relieve the exterior syndrome, the function of removing dampness heat clearing away, and with this medicine treatment urticaria, the cycle of taking is short, and side effect is little, and therapeutic effect is remarkable.The Chinese patent literature of publication number CN 101721536 A (application number 200810194989.9) discloses a kind of medicine for the treatment of papular urticaria, is that raw material is made by Radix Saposhnikoviae, Radix Arnebiae (Radix Lithospermi), the Radix Rehmanniae, Indigo Naturalis, the Radix Astragali, the Radix Paeoniae Alba, Radix Glycyrrhizae.It claims that result of use of the present invention is good, determined curative effect, and effective percentage is up to more than 90%.Publication number CN 101612253 A(application numbers 200910067318.0) Chinese patent literature discloses a kind of pharmaceutical composition that is used for the treatment of papular urticaria, belongs to Chinese medicine.Include the active substance by following weight fraction ratio: 7 parts of cimicifugosides, 6.5 parts of Periostracum Cicadae ethanol extract, 14 parts of betanins, 8.5 parts of Rhzoma Atractylodis Lanceae volatile oils, 17 parts of Semen Lini extracts, 14 parts of Radix Angelicae Sinensis polysaccharides, 27.5 parts of Radix Rehmanniae extracts, 4.5 parts of Caulis Aristolochiae Manshuriensis extracts, 5.5 parts of Herba Schizonepetae volatile oils, 5 parts in Gypsum Fibrosum, 6 parts of glycyrrhizic acids.It claims that the present invention is used for the treatment of papular urticaria, also is used for eczema, skin pruritus.
More than the medicine of various treatment urticaria, no matter be that different curative effects all appear in Chinese medicine or Western medicine, greatly alleviated patient's misery, weak point is that the medication cycle is long, easily recurs.
Summary of the invention
For the deficiencies in the prior art, order of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine wet tissue of papular urticaria, it has heat-clearing and toxic substances removing, the antipruritic function of dampness removing, have no pain, easily accept, characteristics evident in efficacy, and it adopts comparatively common in the localities Chinese crude drug as raw material, and is with low cost.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of treat papular urticaria the preparation method of Chinese medicine wet tissue, it is characterized in that: with the primary raw material of following weight proportion:
15 ~ 30 parts of 40 ~ 80 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
20 ~ 30 parts of 20 ~ 40 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
10 ~ 50 parts of 15 ~ 35 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
20 ~ 40 parts of Cortex Dictamni
Each raw material is cleaned mixing, add the water of 25 ~ 30 times of raw material weights, soak 40-90min, boil with high heat pot, use slow fire instead, keep slight boiling condition to decoct 20-40 minute, filtering residue, in the nonwoven of will the sterilizing layout filtrate, dipping gets the finished product wet tissue.
Foregoing preparation method, preferred scheme is: the primary raw material with following weight proportion is prepared from:
16 ~ 28 parts of 45 ~ 75 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
22 ~ 30 parts of 22 ~ 38 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
15 ~ 45 parts of 15 ~ 32 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
22 ~ 38 parts of Cortex Dictamni.
Foregoing preparation method, preferred scheme is: the primary raw material with following weight proportion is prepared from:
18 ~ 26 parts of 50 ~ 70 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
22 ~ 28 parts of 24 ~ 36 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
20 ~ 40 parts of 15 ~ 30 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
25 ~ 35 parts of Cortex Dictamni.
Foregoing preparation method, preferred scheme is: the primary raw material with following weight proportion is prepared from:
20 parts of 60 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
25 parts of 25 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
30 parts of 25 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
30 parts of Cortex Dictamni.
Foregoing preparation method, preferred scheme is: water consumption is 26-28 times (preferred 27 times) of raw material gross weight.
Foregoing preparation method, preferred scheme is that the time of immersion is 50-70 minute (preferred 60 minutes).
Foregoing preparation method, preferred scheme is that the time that keeps slight boiling condition to decoct is 25-35 minute (preferred 30 minutes).
Foregoing preparation method, preferred scheme is that described wet tissue specification is 18.5cm * 18.5cm.
This Chinese medicine wet tissue is remarkable for the papular urticaria therapeutic effect, and have no pain, easily accept, characteristics evident in efficacy.
The pharmacological effect that the present invention treats each crude drug of Chinese medicine wet tissue of papular urticaria is:
Cortex Phellodendri, nature and flavor: hardship, cold.Gui Jing: return kidney, urinary bladder channel.Effect: heat clearing and damp drying, pathogenic fire purging is except steaming, and skin ulcer is treated in detoxifcation.Cure mainly: be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi , flaccidity of feet with lamenness, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
Radix Sophorae Flavescentis, nature and flavor: hardship, cold.Gui Jing: GUIXIN, liver, stomach, large intestine, urinary bladder channel.Effect: heat clearing and damp drying, parasite killing, diuresis.Cure mainly: be used for hematodiarrhoea, have blood in stool. jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy.
Flos Lonicerae, nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, wind-heat dissipating.Cure mainly: be used for the carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.
Rhizoma Smilacis Glabrae, nature and flavor: sweet light, flat.Gui Jing: return liver, stomach, spleen channel.Function: detoxifcation, dehumidifying, sharp joint.Cure mainly: control syphilis, stranguria with turbid discharge, the muscles and bones spasm and pain, beriberi is treated furuncle, carbuncle, the limbs contracture due to the scrofula, syphilis and mercurialism, bones and muscles pain.
The Fructus Kochiae, nature and flavor: hot, bitter, cold.Gui Jing: return kidney, urinary bladder channel.Effect: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Cure mainly: be used for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Radix Arnebiae (Radix Lithospermi), nature and flavor: sweet, salty, cold.Gui Jing: GUIXIN, Liver Channel.Effect: removing heat from blood, invigorate blood circulation the detoxifcation rash.Cure mainly: be used for the heat in blood poison and contain, class's rash is purple black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Cortex Dictamni, nature and flavor: hardship, cold.Gui Jing: return spleen, stomach, urinary bladder channel.Effect: heat clearing and damp drying. the detoxifcation of dispeling the wind.Cure mainly: be used for damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, rheumatism pyretic arthralgia, yellow cellulitis dark coloured urine.
The present invention is used for the treatment of the Chinese medicine wet tissue of papular urticaria, meets the traditional Chinese medical science about the theory of urticaria.For above-mentioned defective in treatment papular urticaria process, this product is gone through for many years clinical research on the basis of summing up forefathers' experience, adopt pure natural draft Chinese medicine unique formula and technique to make with extra care and form.This product includes abundant plant biological active component, can directly act on the affected part.And have no pain, easily accept, characteristics evident in efficacy.
Prescription analysis: Cortex Phellodendri has heat-clearing and toxic substances removing, and the effect of heat clearing and damp drying is monarch drug; The Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating is ministerial drug; Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, the Fructus Kochiae, Radix Arnebiae (Radix Lithospermi), Cortex Dictamni also strengthen for assistant makes that our heat-clearing and toxic substances removing, dampness removing are antipruritic, the effect of antiseptic and inhibiting bacteria function.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1:A kind of Chinese medicine wet tissue of papular urticaria is prepared from (every part of 5g) with the primary raw material of following weight proportion:
30 parts of 80 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
30 parts of 40 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
50 parts of 35 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
40 parts of Cortex Dictamni.
Each raw material is cleaned mixing, add the water of 30 times of raw material weights, soak 90min, boil with high heat pot, use slow fire instead, keep slight boiling condition to decoct 40 minutes, filtering residue, in the nonwoven of will the sterilizing layout filtrate, dipping gets the finished product wet tissue.
Embodiment 2:A kind of Chinese medicine wet tissue for the treatment of papular urticaria is prepared from (every part of 10g) with the primary raw material of following weight proportion:
15 parts of 40 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
20 parts of 20 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
10 parts of 15 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
20 parts of Cortex Dictamni.
The preparation method of described Chinese medicine wet tissue, basic identical with embodiment, but water consumption is 26 times of the raw material gross weight.
Embodiment 3:A kind of Chinese medicine wet tissue for the treatment of papular urticaria is prepared from (every part of 20g) with the primary raw material of following weight proportion:
28 parts of 75 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
30 parts of 38 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
45 parts of 32 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
38 parts of Cortex Dictamni.
Preparation method is basically identical with embodiment 1, but water consumption is 28 times of the raw material gross weight.
Embodiment 4:A kind of Chinese medicine wet tissue for the treatment of papular urticaria is prepared from (every part of 25g) with the primary raw material of following weight proportion:
16 parts of 45 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
22 parts of 22 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
15 parts of 15 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
22 parts of Cortex Dictamni.
Preparation method is basically identical with embodiment 1, but the time of soaking is 50 minutes.
Embodiment 5:A kind of Chinese medicine wet tissue for the treatment of papular urticaria is prepared from (every part of 10g) with the primary raw material of following weight proportion:
25 parts of 65 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
25 parts of 25 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
35 parts of 25 portions of Radix Arnebiae (Radix Lithospermi)s of the Fructus Kochiae
30 parts of Cortex Dictamni.
Preparation method is basically identical with embodiment 1, but the time that keeps slight boiling condition to decoct is 35 minutes.
Embodiment 6:A kind of Chinese medicine wet tissue for the treatment of papular urticaria is prepared from the primary raw material of following weight proportion:
Cortex Phellodendri 60g Radix Sophorae Flavescentis 20g
Flos Lonicerae 25g Rhizoma Smilacis Glabrae 25g
Fructus Kochiae 25g Radix Arnebiae (Radix Lithospermi) 30g
Cortex Dictamni 30g.
Preparation method is each raw material to be cleaned mix, and adds the water of 27 times of raw material weights, soaks 60min, boils with high heat pot, uses slow fire instead, keeps slight boiling condition to decoct 30 minutes.
The best of Chinese medicine wet tissue of the present invention is suitable for the age: child or the child in 0-14 year, have no pain, and easily accept the characteristics such as evident in efficacy.Indication mainly contains: papular urticaria.The course for the treatment of: the front wiping affected part of sleeping every night (person of being in a bad way elder generation note applied the affected part 10 minutes), 1-5 produce effects, 7 days is a course for the treatment of.
Clinical model case (embodiment 6 gained medicines):
Clinical case 1: Mrs's Wang daughter is large two years old 05 months this year, and in May, 2012, the large pale red pimple of Semen phaseoli radiati appears in daughter's trunk and extremity near-end in batch, and the top also has phlycten, and spindle blush is arranged on every side, scratches and grabs rear formation welt, and pimple is very itched.Be diagnosed as papular urticaria, at first adopt the rear sx↓ of the outer wiping of corticosteroid hormone ointment, recur after the drug withdrawal.Rear use Chinese medicine wet tissue of the present invention, the front wiping affected part of sleeping every night, transference cure after 3 days continue to use course for the treatment of of this wet tissue, to consolidate, recurs so far.
Clinical case 2, Mr.'s Sun son Jia Jia, 10 years old, enter cheek in summer, back, medial thigh skin in beginning one in 2011 and erythra occurs, erythra is spindle, begins to be the small rice grain pimple, then it is large to Semen arachidis hypogaeae to develop into Semen Glycines, and erythra is very itched, and whole body is trooped or evacuated distribution.Use Chinese medicine wet tissue of the present invention, advise its front wiping affected part of sleeping.Symptom takes a turn for the better after 3 days, thoroughly cures after the course for the treatment of.
Clinical case 3, Miss Wu's daughter once must cross papular urticaria former years, and this year, summer has set in was had an attack of one's old illness again, at first adopted the rear sx↓ of the outer wiping of corticosteroid hormone ointment, recurred after the drug withdrawal.In in July, 2011 here medical, allow her use the Chinese medicine wet tissue of the present invention of a course for the treatment of, advise its wiping affected part before sleeping, erythema disappears after 5 days, continues to use this wet tissue thoroughly to cure after a course for the treatment of.
Test example 1(embodiment 6 gained medicines):
" the new Chinese medicine guideline of clinical investigations " formulated according to Ministry of Public Health 1993 be diagnosis basis, and totally 200 routine ages are at the child patient of suffering from papular urticaria between 0-14 year, wherein, boy 96 people, girl 104 people, the mean age is 3.8 years old.Random division is administration group and matched group.
The previous day before experiment, record patient's health comprises the skin surface situation, pruritus degree, erythra distribution and emotion changes (determining by question and answer and answer test problem), look over the patient body symptom every day, guarantee that administration group and matched group situation are basically identical.The administration group is used this product wiping affected part every day just before going to bed, and 7 days is a course for the treatment of.Check the patient body situation every day, make a record.Result such as following table 1:
Table 1:
Self-induction symptom and emotion changes result such as table 2:
Table 2:
Efficacy analysis:The most patient sensory symptoms obviously alleviated when administration group (Chinese medicine wet tissue of the present invention) was used 3 days, and urticaria reduces, and scratchiness is no longer strong, patient's emotion takes a turn for the better, use this wet tissue in the time of 5 days patient be almost recovered, urticaria disappears, the existence of imperceptible pruritus, spiritual cephalopodium, in a good humor.Stop using a period of time to have no repeatedly, the state of an illness is better controlled.The matched group rear curative effect of taking medicine is obvious, but 94% patient is recurred again after stopping using.
In sum, Chinese medicine wet tissue effect of the present invention is remarkable, Most patients use this wet tissue after 3 days symptom be clearly better, scratchiness disappears, comparatively severe patient use this wet tissue after 5 days symptom also can be improved significantly.
Should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, and a lot of distortion can also be arranged.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.