CN102861273B - Preparation method of traditional Chinese medicine wet wipes for treating exudative children eczema - Google Patents
Preparation method of traditional Chinese medicine wet wipes for treating exudative children eczema Download PDFInfo
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Abstract
The invention discloses a preparation method of traditional Chinese medicine wet wipes for treating exudative children eczema. According to the preparation method, amur corktree barks, lightyellow sophora roots, honeysuckle, glabrous greenbrier rhizome, belvedere fruits, garden burnet roots and alum are used as main raw materials and are prepared into the traditional Chinese medicine wet wipes according to conventional preparation processes. The traditional Chinese medicine wet wipes has functions of clearing heat, removing toxicity, promoting diuresis and relieving itching and has the advantages of being easy to accept and obvious in treatment effects, users are pain-free and not prone to be allergic, and local common traditional Chinese medicinal materials are used as the raw materials so that costs are low.
Description
Technical field
The present invention relates to Chinese medicine field, particularly a kind of preparation method for the treatment of the Chinese medicine wet tissue of exudative infantile eczema.
Background technology
Infantile eczema is the common a kind of dermatosis of cradle, and most erythra are at buccal, forehead, glabella and head.The child who suffers from eczema originally skin rubefaction, occur erythra, then skin send out rough, desquamation, heat, meet and wetly all can make eczema performance significantly.The cause of disease that causes infant eczema is complicated, and wherein irritated factor is topmost, therefore has the infant of allergic constitution family history that eczema just easily occurs.Except irritated factor, many materials also can bring out or add celsus' papules symptom, as protein, chemical substance, woolen knitwear, chemical fibre article, animal skin and feather etc. in food.Easily there is the factor that eczema also has itself in infant, because baby's keratodermatitis is thinner, capillary network is abundant and endothelium is moisture and chloride is many, more responsive to various stimulating factors, infantile eczema itself is not by due to humidity, but humidity can impel eczema to increase the weight of.Infantile eczema can be divided into drying type, seborrhea type and exudative type type.Exudative infantile eczema is more common in more fat baby, has chickenpox and erythema between red rash, can have skin histology swelling phenomenon, itches very much, has yellow slurry to ooze out or hemorrhage after scratching, and erythra can spread to trunk, extremity and whole body, and easy secondary skin infection.
Existing western medical treatment means are mainly the medicines of taking containing 17-hydroxy-11-dehydrocorticosterone, this therapy can be selected light disease or the little eczema of scope, to the large eczema of area or the eczema of outbreak repeatedly, if frequent or a large amount of prolonged application is containing the medicine of 17-hydroxy-11-dehydrocorticosterone, have the side effect of whole body and local skin.And the traditional Chinese medical science is particular about dialectical treating, according to patient's different situations, comprise the difference of symptom and the difference of body constitution, carry out dialectical treatment, can allow like this patient start with from the cause of disease and treat, obtain the effect of good symptomatic treatment.The Chinese patent literature of publication number CN 102293851 A (application number 201110249101.9) discloses a kind of Chinese medicine for outer use and preparation method of the baby's for the treatment of exudative type eczema, and said preparation is by following raw materials according, to be made by weight: 3～8 parts of 5～15 parts of Radix Saposhnikoviaes, 5～15 parts of Fructus Forsythiaes, 3～8 parts of Indigo Naturaliss, 5～10 parts of Herba Patriniae, 3～8 parts of Radix Sophorae Flavescentiss, 3～8 parts of Fructus Cnidiis, 5～10 parts of Cortex Phellodendris, 5～15 parts of Radix Et Rhizoma Rhei, 3～8 parts of Radix Scutellariaes and Calaminas.It claims that the preparation for treating mode of this invention is simple, infant is easy to use, no pain in therapeutic process, instant effect, safe, have no side effect, cure rate can reach more than 80%, and it is low to have cost, does not recur after more.The Chinese patent literature of publication number CN 102119976 A (application number 201110053085.6) discloses a kind of external preparation for the treatment of Acute inflammatory exudation dermatoses, said preparation is made by the crude drug of following weight portion: Radix Sophorae Flavescentis 2-6, Radix Sanguisorbae 2-4, Galla Chinensis 1-3, Cortex Phellodendri 2-5, Fructus Kochiae 2-5, Radix Clematidis 2-5, Herba speranskiae tuberculatae 2-5, dried Alumen 1-3.It claims that the affected part that is imposed on Acute inflammatory exudation dermatoses has heat clearing and damp drying, holds back wet antipruritic merit, therefore wind, heat, poison, wetly all can remove, can hold back, and effect is remarkable.Publication number CN 102302625 A(application numbers 201110250472.9) Chinese patent literature discloses a kind of medicament for the treatment of infantile eczema, and it is to be made by following bulk drugs: Fructus Xanthii, Rhizoma Acori Graminei, the Fructus Kochiae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Herba Equiseti Hiemalis, Cortex Dictamni, Borneolum Syntheticum, Radix Aconiti Kusnezoffii, Camphora, Fructus Cnidii and dried Alumen.It claims that this drug prescription is reasonable, and curative effect is clear and definite, can effectively treat infantile eczema.Publication number CN 102600398 A(application numbers 201210102546.9) Chinese patent literature discloses a kind of Chinese medicine composition for the treatment of infantile eczema, and this Chinese medicine composition is that Radix Sophorae Flavescentis, Fructus Arctii, Semen Coicis, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, Radix Berberidis, Rhizoma Atractylodis, Pollen Pini, Cortex Phellodendri are made.
With regard to prior art, the exudative eczema instant effect of western medicine, but easily produce drug dependence, and outbreak repeatedly, after external corticoid, eczema disease makes rapid progress, once, just can there is crimson, tenderness, pruritus, breach, desquamation in drug withdrawal, so that pustule occurs at innerlich anwenden a couple of days position, eczema more increases the weight of, when recoating with after hormone, the state of an illness takes a turn for the better very soon or disappears, as drug withdrawal again, eczema is sent out again, and than more serious in the past.Treatment by Chinese herbs primary disease take heat-clearing and toxic substances removing, dampness removing is antipruritic, removing heat from blood is moisturized, blood circulation promoting and blood stasis dispelling is principle, can treat according to different pattern of syndrome are dialectical.Have at present many external Chinese medicinal ointments available, but clinical discovery is used merely the curative effect of ointment unsatisfactory.
Summary of the invention
For the deficiencies in the prior art, the object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine wet tissue of exudative infantile eczema, it has heat-clearing and toxic substances removing, the antipruritic function of dampness removing, there is no pain, easily accept, evident in efficacy, be difficult for irritated feature, and it adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a preparation method for the Chinese medicine wet tissue of exudative infantile eczema, by the primary raw material of following weight proportioning:
15 ~ 30 parts of 45 ~ 75 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
15 ~ 45 parts of 20 ~ 45 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
15 ~ 40 parts of 15 ~ 40 portions of Radix Sanguisorbaes of the Fructus Kochiae
10 ~ 20 parts of Alumens
Each raw material is cleaned and mixed, add the water of 25 ~ 30 times of raw material weights, soak 40-90min, boil with high heat pot, use slow fire instead, keep slight boiling condition to decoct 20-40 minute, filtering residue, the nonwoven of sterilizing arranges that, in filtrate, dipping, obtains finished product wet tissue.
Foregoing preparation method, preferred scheme is: the primary raw material with following weight proportion is prepared from:
16 ~ 28 parts of 50 ~ 70 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
20 ~ 40 parts of 22 ~ 42 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
20 ~ 35 parts of 20 ~ 35 portions of Radix Sanguisorbaes of the Fructus Kochiae
12 ~ 18 parts of Alumens.
Foregoing preparation method, preferred scheme is: the primary raw material with following weight proportion is prepared from:
18 ~ 26 parts of 55 ~ 65 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
25 ~ 35 parts of 25 ~ 40 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
22 ~ 30 parts of 22 ~ 30 portions of Radix Sanguisorbaes of the Fructus Kochiae
14 ~ 16 parts of Alumens.
Foregoing preparation method, preferred scheme is: the primary raw material with following weight proportion is prepared from:
20 parts of 60 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
30 parts of 30 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
25 parts of 25 portions of Radix Sanguisorbaes of the Fructus Kochiae
15 parts of Alumens.
Foregoing preparation method, preferred scheme is: water consumption is 26-28 times (preferably 27 times) of raw material gross weight.
Foregoing preparation method, preferred scheme is: the time of immersion is 50-70 minute (preferably 60 minutes).
Foregoing preparation method, preferred scheme is: the time that keeps slight boiling condition to decoct is 25-35 minute (preferably 30 minutes).
Foregoing preparation method, preferred scheme is: described wet tissue specification is 18.5cm * 18.5cm.
This Chinese medicine wet tissue is remarkable for exudative infantile eczema therapeutic effect, and there is no pain, easily accept, evident in efficacy, be difficult for irritated feature.
The pharmacological effect that the present invention treats each crude drug of Chinese medicine wet tissue of exudative infantile eczema is:
Cortex Phellodendri, nature and flavor: hardship, cold.Gui Jing: return kidney, urinary bladder channel.Effect: heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.Cure mainly: for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi ， flaccidity of feet with lamenness, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
Radix Sophorae Flavescentis, nature and flavor: hardship, cold.Gui Jing: GUIXIN, liver, stomach, large intestine, urinary bladder channel.Effect: heat clearing and damp drying, parasite killing, diuresis.Cure mainly: for hematodiarrhoea, have blood in stool. jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy.
Flos Lonicerae, nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Effect: heat-clearing and toxic substances removing, wind-heat dissipating.Cure mainly: for carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.
Rhizoma Smilacis Glabrae, nature and flavor: sweet light, flat.Gui Jing: return liver, stomach, spleen channel.Function: removing toxic substances, dehumidifying, sharp joint.Cure mainly: control syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, treats furuncle, carbuncle, scrofula, the limbs contracture due to syphilis and mercurialism, bones and muscles pain.
The Fructus Kochiae, nature and flavor: pungent, bitter, cold.Gui Jing: return kidney, urinary bladder channel.Effect: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.Cure mainly: for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Radix Sanguisorbae, nature and flavor: bitter, acid, puckery, is slightly cold.Gui Jing: return liver, large intestine channel.Effect: cooling blood for hemostasis, removing toxic substances sore.Cure mainly: for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Alumen, nature and flavor: sour, puckery, cold.Gui Jing: return lung, spleen, liver, large intestine channel.Effect: external removing toxic substances parasite killing, dampness removing to stop itchin; Hemostasis antidiarrheal for oral administration, dispels wind-phlegm.Cure mainly: external treatment is for eczema, scabies, Ting discharging ear; Take orally for incessant chronic diarrhea, have blood in stool, metrorrhagia, epilepsy is gone mad.Dried Alumen removing dampness sore, hemostasisization is rotten.For eczema eczema, Ting discharging ear, pudendal pruritus leukorrhagia, epistaxis bleeding from the gum, nose Xi meat.
The present invention is used for the treatment of the Chinese medicine wet tissue of exudative infantile eczema, meets the traditional Chinese medical science about the theory of eczema.For above-mentioned defect in the exudative infantile eczema process for the treatment of, this product, summing up on the basis of forefathers' experience, is gone through clinical research for many years, adopts pure natural draft Chinese medicine unique formula and technique to refine and forms.This product includes abundant plant biological active component, can directly act on affected part.And there is no pain, easily accept, evident in efficacy, be difficult for irritated feature.
Prescription analysis: Cortex Phellodendri has heat-clearing and toxic substances removing, the effect of heat clearing and damp drying, is monarch drug; Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating, is ministerial drug; Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae, the Fructus Kochiae, Radix Sanguisorbae, Alumen our heat-clearing and toxic substances removing, dampness removing are antipruritic, the effect of antiseptic and inhibiting bacteria function for assistant makes to strengthen.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1:treat a Chinese medicine wet tissue for exudative infantile eczema, with the primary raw material of following weight proportion, be prepared from (every part of 5g):
30 parts of 75 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
45 parts of 45 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
40 parts of 40 portions of Radix Sanguisorbaes of the Fructus Kochiae
20 parts of Alumens.
Each raw material is cleaned and mixed, add the water of 30 times of raw material weights, soak 90min, boil with high heat pot, use slow fire instead, keep slight boiling condition to decoct 40 minutes, filtering residue, the nonwoven of sterilizing arranges that, in filtrate, dipping, obtains finished product wet tissue.
embodiment 2:treat a Chinese medicine wet tissue for exudative infantile eczema, with the primary raw material of following weight proportion, be prepared from (every part of 10g):
15 parts of 45 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
15 parts of 20 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
15 parts of 15 portions of Radix Sanguisorbaes of the Fructus Kochiae
10 parts of Alumens.
The preparation method of described Chinese medicine wet tissue, basic identical with embodiment, but water consumption is 26 times of raw material gross weight.
embodiment 3:treat a Chinese medicine wet tissue for exudative infantile eczema, with the primary raw material of following weight proportion, be prepared from (every part of 20g):
28 parts of 70 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
40 parts of 42 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
35 parts of 35 portions of Radix Sanguisorbaes of the Fructus Kochiae
18 parts of Alumens.
Preparation method is substantially identical with embodiment 1, but water consumption is 28 times of raw material gross weight.
embodiment 4:treat a Chinese medicine wet tissue for exudative infantile eczema, with the primary raw material of following weight proportion, be prepared from (every part of 25g):
16 parts of 50 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
20 parts of 22 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
20 parts of 20 portions of Radix Sanguisorbaes of the Fructus Kochiae
12 parts of Alumens.
Preparation method is substantially identical with embodiment 1, but the time of soaking is 50 minutes.
embodiment 5:treat a Chinese medicine wet tissue for exudative infantile eczema, with the primary raw material of following weight proportion, be prepared from (every part of 10g):
18 parts of 55 parts of Radix Sophorae Flavescentiss of Cortex Phellodendri
25 parts of 25 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae
22 parts of 22 portions of Radix Sanguisorbaes of the Fructus Kochiae
14 parts of Alumens.
Preparation method is substantially identical with embodiment 1, but the time that keeps slight boiling condition to decoct is 35 minutes.
embodiment 6:treat a Chinese medicine wet tissue for exudative infantile eczema, with the primary raw material of following weight proportion, be prepared from:
Cortex Phellodendri 60g Radix Sophorae Flavescentis 20g
Flos Lonicerae 30g Rhizoma Smilacis Glabrae 30g
Fructus Kochiae 25g Radix Sanguisorbae 25g
Alumen 15g.
Preparation method, is that each raw material is cleaned and mixed, and adds the water of 27 times of raw material weights, soaks 60min, boils with high heat pot, uses slow fire instead, keeps slight boiling condition to decoct 30 minutes.
The applicable age of the best of Chinese medicine wet tissue of the present invention: child or the child in 0-14 year, there is no pain, easily accept, evident in efficacy, be difficult for the features such as irritated.Indication mainly contains: exudative infantile eczema.The course for the treatment of: wiping before sleeping every night (the first note of the person of being in a bad way applies affected part 10 minutes), 1-5 time effective, 7 days is a course for the treatment of.
clinical model case (embodiment 6 gained medicines):
Clinical pathology 1: Mr. Han, man, 32 years old, in June, 2010, red rash on buccal and shirtfront skin, had chickenpox and erythema to daughter Fang Fang (one-year-old 04 months are large) between erythra, has yellow slurry to flow out after scratching.Be diagnosed as eczema infantile eczema, at first adopt Hormonal ointment to smear affected part, symptom alleviated at that time, can after drug withdrawal, recur again.Here was medical afterwards, used Chinese medicine wet tissue of the present invention, wiping before sleeping every night, transference cure after 5 days, so far not recurrence.
Clinical case 2, Zhao, female, 6 years old, people from Linyi, Shandong, during annual summer has set in, forehead, buccal, skin of axillary fossa are red and swollen around, have erythema, itch very much, hemorrhage after scratching, through inquiry, learn that it is to pollen hypersensitivity, and during heat, erythema becomes many.In in July, 2011 here medical, allow her use the Chinese medicine wet tissue of the present invention of a course for the treatment of, after 3 days, erythema disappears, and continues to use a course for the treatment of of this wet tissue, consolidates recurrence so far doing.
test example (embodiment 6 gained medicines):
The < < new Chinese medicine guideline of clinical investigations > > formulating for 1993 according to Ministry of Public Health is diagnosis basis, totally 200 example ages are at the child patient of suffering from exudative infantile eczema between 0-14 year, wherein, boy 102 people, girl 98 people, the mean age is 5.5 years old.Random division is medication group and matched group.
The previous day before experiment, record patient's health, comprise skin surface situation, pruritus degree, erythema distribution and emotion changes (by question and answer and answer test problem, determining), look over patient body symptom every day, guarantee that medication group and matched group situation are basically identical.Medication group is used this product wiping affected part every day just before going to bed, within 7 days, is a course for the treatment of.Check patient body situation every day, make a record.Result is as following table 1:
Table 1:
efficacy analysis:when administration group (Chinese medicine wet tissue of the present invention) is used 3 days, most patient sensory symptoms obviously alleviates, and skin erythema reduces, and scratchiness is no longer strong, and while using 5 days, patient is almost recovered, and skin erythema disappears, the existence of imperceptible pruritus.Drug withdrawal a period of time has no repeatedly, and the state of an illness is better controlled.Matched group take medicine after curative effect obvious, but after drug withdrawal, 93% patient is recurred again.
In sum, Chinese medicine wet tissue effect of the present invention is remarkable, Most patients use this wet tissue after 3 days symptom be clearly better, skin erythema reduces, scratchiness disappears, comparatively severe patient use this wet tissue after 5 days symptom also can be improved significantly.
It should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (9)
1. treat the preparation method of the Chinese medicine wet tissue of exudative infantile eczema, it is characterized in that: take off the raw material of stating weight proportion:
Each raw material is cleaned and mixed, add raw material weight 26-28 water doubly, soak 50-70min, boil with high heat pot, use slow fire instead, keep slight boiling condition to decoct 20-40 minute, filtering residue, the nonwoven of sterilizing arranges that, in filtrate, dipping, obtains finished product wet tissue.
2. preparation method according to claim 1, is characterized in that, each raw material:
3. preparation method according to claim 1, is characterized in that, each raw material:
4. preparation method according to claim 1, is characterized in that, each raw material:
5. preparation method according to claim 1, is characterized in that: water consumption is 27 times of raw material gross weight.
6. preparation method according to claim 1, is characterized in that, the time of immersion is 60 minutes.
7. preparation method according to claim 1, is characterized in that, the time that keeps slight boiling condition to decoct is 25-35 minute.
8. preparation method according to claim 7, is characterized in that, the time is 30 minutes.
9. preparation method according to claim 1, is characterized in that, described wet tissue specification is 18.5cm * 18.5cm.
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